WO2020151039A1 - 一种细胞检测显微镜 - Google Patents

一种细胞检测显微镜 Download PDF

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WO2020151039A1
WO2020151039A1 PCT/CN2019/075531 CN2019075531W WO2020151039A1 WO 2020151039 A1 WO2020151039 A1 WO 2020151039A1 CN 2019075531 W CN2019075531 W CN 2019075531W WO 2020151039 A1 WO2020151039 A1 WO 2020151039A1
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axis
lens
plate
support frame
translation device
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PCT/CN2019/075531
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French (fr)
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殷跃锋
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殷跃锋
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure

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  • the invention relates to the technical field of electron microscopes, in particular to a cell detection microscope.
  • the cell detection microscope it is an instrument that can perform microscopic observation and detection after a certain degree of magnification of the cell sample specimen to be detected.
  • people use cell detection microscopes to conduct microscopic research on human cell tissues and blood samples. It is necessary to use cell detection microscopes to take pictures of microstructures to obtain clear pictures.
  • current microscopes have three problems when observing at high magnifications: The first is that the lens is oscillating up and down and the scanning focal length is very small. If the image surface of the lens and the sample surface do not overlap, the image will appear half clear and half blurred; the second is that the current cell inspection microscope moves in the Y axis direction when moving horizontally. The vibration will be transmitted to the X-axis sliding device.
  • the vibration in the Y-axis direction will cause a large height error between the lens and the glass, which affects the position accuracy of the imaging;
  • the cell detection microscope has little force in the vertical direction, and the above problems need to be improved urgently.
  • the technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a cell detection microscope with a reasonable structure, which improves the vertical force, improves the imaging definition, and improves the position accuracy of the imaging.
  • a cell detection microscope including a reference base plate, a Z-axis support frame is provided on the top side of the reference base plate, and a first A servo motor, a screw rod axially connected to the first servo motor is rotatably provided in the Z-axis support frame, a shooting bracket is slidably sleeved on the screw rod, and a laser tube is provided on the top of the shooting bracket.
  • the top of the laser tube is provided with a lens tube communicating with the laser tube, and the top of the lens tube is provided with a camera communicating with it;
  • the Z-axis support frame at the side of the laser tube is provided with a driving piezoelectric component, and the bottom of the Z-axis support frame is provided with a lens force plate contacting the driving piezoelectric component, and the lens force plate rotates
  • An automatic objective lens wheel is provided on the automatic objective lens wheel with at least one lens communicating with the laser tube, and a second servo motor axially connected to the automatic objective lens wheel is provided on the side of the lens booster plate;
  • An oil tank is provided on the reference bottom plate under the shooting bracket, and the top of the oil tank is provided with a light source corresponding to the lens;
  • the upper part of the reference base plate is provided with a Y-axis translation device, the top of the Y-axis translation device is provided with an X-axis translation device, and the top of the X-axis translation device is provided with a glass slide rack and a glass slide rack vertical adjustment device.
  • the number of the lens is one.
  • the X-axis translation device includes an X-axis support, and a fixed plate connected to the slide holder is slidably provided on the X-axis support, and the side of the X-axis support is provided with a fixed plate through a soft connecting rope.
  • the top of the X-axis bracket is also provided with an adjuster for adjusting the tightness of the soft connecting rope, and the soft connecting rope is a steel wire rope.
  • the Y-axis translation device includes a moving plate slidably arranged on a reference base plate and a passive drive bracket.
  • the two ends of the passive drive bracket are respectively provided with limit rods close to the side of the moving plate.
  • a limit block corresponding to the movable plate is arranged on the upper part, the top of the passive drive bracket is fixed with the X-axis bracket, and the two limit rods are close to the universal wheels on the sides of the movable plate that are in contact with the movable plate.
  • the workpiece for driving the piezoelectric component in the vertical direction is a high-thrust piezoelectric stack made of piezoelectric ceramics
  • the detection workpiece for the driving piezoelectric component is a 0.1um precision grating ruler
  • the driving piezoelectric component The control power supply of the components adopts a high-thrust piezoelectric stack made of piezoelectric ceramics, a 0.1um precision grating ruler, and a lens afterburner to form a closed-loop system.
  • the high-thrust piezoelectric stack made of piezoelectric ceramics uses 0.2 The accuracy within um is reciprocating at a frequency of 600HZ.
  • the total weight of the automatic objective lens wheel and at least one lens is 5KG.
  • the translation speed of the X-axis fixed plate is 300 mm per second, and the height error of the slide rack caused by vibration during the translation of the fixed plate is within 0.2um.
  • the present invention Compared with the prior art, the present invention has the advantage that: the present invention energizes the driving piezoelectric component through the above technical solution, the high-thrust piezoelectric stack will be forced along the Z axis (ie the vertical direction), and the high-thrust pressure
  • the stack and the 0.1um precision grating form a closed loop system, which controls the automatic objective wheel and the lens with a weight of 5KG to reciprocate at a frequency of 600HZ within 0.2um per second to achieve the scanning function and improve the vertical force.
  • the lens oscillates up and down to scan the focal length to increase the imaging clarity; the adjuster can improve the accuracy of the movement in the X-axis direction, and the universal wheel can eliminate the force in the Z-axis direction, which prevents the transmission of vibration in the traditional transmission mode during the movement.
  • the Y-axis translation device and the X-axis translation device it is ensured that the height error between the lens and the slide caused by vibration is within 0.2um during the scanning process of the machine at 30mm/sec on the X axis, thereby improving the imaging performance Position accuracy.
  • Figure 1 is a schematic diagram of the structure of the present invention.
  • Fig. 2 is a schematic diagram of the enlarged structure at A in the present invention.
  • Base plate 2.
  • Z-axis support frame 21 The first servo motor 22.
  • Drive piezoelectric components 31.
  • Light source 5. Y-axis translation device 51. Moving plate 52. Limit lever 6.
  • X-axis translation device 62. Fixed plate 63.
  • X-axis bracket 64 Fixed plate 63.
  • X-axis bracket 64 Fixed plate 63.
  • a cell detection microscope includes a reference base plate 1, a Z-axis support frame 2 is provided on the top side of the reference base plate 1, and a first servo motor 21 is provided on the top of the Z-axis support frame 2 ,
  • the Z-axis support frame 2 is rotatably provided with a screw rod axially connected to the first servo motor 21, a photographing bracket 22 is slidingly sleeved on the screw rod, and a laser tube 23 is provided on the top of the photographing bracket 22 ,
  • the top of the laser tube 23 is provided with a lens barrel 24 communicating with the laser tube 23, and the top of the lens barrel 24 is provided with a camera 25 communicating with it;
  • the Z-axis support frame 2 on the side of the laser tube 23 is provided with a driving piezoelectric component 3, and the bottom of the Z-axis support frame 2 is provided with a lens booster plate 31 contacting the driving piezoelectric component 3.
  • the lens booster plate 31 is rotatably provided with an automatic objective wheel 32, the automatic objective wheel 32 is provided with at least one lens 33 communicating with the laser tube 23, and the side of the lens booster plate 31 is provided with an automatic objective wheel 32 axially connected second servo motor 34;
  • An oil tank 4 is provided on the reference base plate 1 under the shooting bracket 22, and a light source 41 corresponding to the lens 33 is provided on the top of the oil tank 4;
  • the upper part of the reference base plate 1 is provided with a Y-axis translation device 5, the top of the Y-axis translation device 5 is provided with an X-axis translation device 6, and the top of the X-axis translation device 6 is provided with a slide rack 7 and a glass slide.
  • Frame vertical adjustment device 71 is provided.
  • the number of the lens 33 is one, and the X-axis translation device 6 includes an X-axis support 63.
  • the X-axis support 63 is slidably provided with a fixing plate 62 connected to the slide holder 7 and the X-axis support
  • the side of the 63 is provided with a third servo motor which is axially connected to the fixed plate 62 by a soft connecting rope 64.
  • the top of the X-axis bracket 63 is also provided with an adjuster 65 for adjusting the tightness of the soft connecting rope 64.
  • 64 is a steel wire rope.
  • the Y-axis translation device 5 includes a moving plate 51 slidably arranged on the reference base plate 1 and a passive drive bracket.
  • the two ends of the passive drive bracket are respectively provided with limit rods 52 close to the side of the moving plate 51.
  • the reference base plate 1 is provided with a limit block corresponding to the moving plate 51, the top of the passive drive bracket is fixed to the X-axis bracket 63, and the two limit rods 52 are close to the moving plate 51 on the side 51 contact universal wheels.
  • the workpiece for driving the piezoelectric component 3 in the vertical direction is a high-thrust piezoelectric stack made of piezoelectric ceramics
  • the detection workpiece of the driving piezoelectric component 3 is a 0.1um precision grating ruler
  • the control power supply of 3 adopts a high-thrust piezoelectric stack made of piezoelectric ceramics, a 0.1um precision grating ruler and a lens afterburner 31 to form a closed loop system.
  • the high-thrust piezoelectric stack made of piezoelectric ceramics Reciprocating motion at 600HZ frequency within 0.2um.
  • the total weight of the automatic objective wheel 32 and the at least one lens 33 is 5KG.
  • the translation speed of the X-axis fixed plate 62 is 30 mm per second, and the height error of the slide holder 7 caused by vibration during the translation of the fixed plate 62 is within 0.2um.
  • the high-thrust piezoelectric stack when the driving piezoelectric component 3 is energized, the high-thrust piezoelectric stack will be applied along the Z axis (ie the vertical direction), and the high-thrust piezoelectric stack and the 0.1um precision grating ruler form a closed loop system to control the weight
  • the 5KG automatic objective wheel 32 and the lens 33 reciprocate at a frequency of 600HZ with an accuracy of 0.2um per second to achieve the scanning function, improve the vertical force, the lens oscillates up and down to scan the focal length and increase the imaging clarity; adjustment
  • the device 65 can improve the accuracy of the movement in the X-axis direction, and the universal wheel can eliminate the force in the Z-axis direction, preventing the vibration from the traditional transmission mode from being transmitted to the Y-axis translation device and the X-axis translation device during the movement process.
  • the height error between the lens and the slide caused by vibration is within 0.2um, which improves the position accuracy of the imaging.

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

一种细胞检测显微镜，包括基准底板（1），基准底板（1）顶部一侧设有Z轴支持架（2），Z轴支持架（2）的顶部设有第一伺服电机（21），Z轴支持架（2）内旋转设有与第一伺服电机（21）轴向相连的丝杆，丝杆上滑动套接有拍摄支架（22），拍摄支架（22）的顶部设有拍照机构；拍照机构侧部的Z轴支持架（2）上设有驱动压电部件（3），Z轴支持架（2）的底部设有镜头装置；拍摄支架（22）下方的基准底板（1）上设有盛油槽（4），盛油槽（4）的顶部设有与镜头装置相应的光源（41）；基准底板（1）的Y轴平移装置（5），Y轴平移装置（5）的顶部设有X轴平移装置（6），X轴平移装置（6）的顶部设有载玻片架（7）和载玻片架垂直调节装置（71），从而提高了竖直方向加力，镜头（33）上下震荡扫描焦距增加，提高了成像清晰度，提高了成像的位置精度。

Description

一种细胞检测显微镜 技术领域
本发明涉及电子显微镜技术领域，具体是指一种细胞检测显微镜。
背景技术
对于细胞检测显微镜来说，它是一种可以对所需要检测的细胞样品标本进行一定程度的放大后进行显微观察检测的仪器。目前，人们使用细胞检测显微镜对人体细胞组织以及血液样本进行微观的研究，需要利用细胞检测显微镜对微观结构进行拍照，获得清晰的照片，但目前的显微镜在高倍镜观察时，存在三个问题：一是镜头上下震荡扫描焦距很小，如果镜头的像面与样本面不重叠时，成像就会出现一半清晰，一半模糊的情况；二是现今的细胞检测显微镜在做水平移动时Y轴方向的震动会传递到X轴滑移装置上，由于X轴滑移装置与载玻片直接接触，Y轴方向的震动会镜头与玻片之间高度误差较大，影响成像的位置精度；三是现今的细胞检测显微镜在竖直方向加力小，以上问题亟待改进。
发明内容
本发明要解决的技术问题是，克服现有技术缺点，提供一种细胞检测显微镜，结构合理，提高竖直方向加力，提高成像清晰度，提高成像的位置精度。
为解决上述技术问题，本发明提供的技术方案为：一种细胞检测显微镜，包括基准底板，所述基准底板顶部一侧设有Z轴支持架，所述Z轴支持架的顶部设有第一伺服电机，所述Z轴支持架内旋转设有与第一伺服电机轴向相连的丝杆，所述丝杆上滑动套接有拍摄支架，所述拍摄支架的顶部设有激光筒，所述激光筒的顶部设有与激光筒相连通的镜筒，所述镜筒的顶部设有与其相连通的相机；
所述激光筒侧部的Z轴支持架上设有驱动压电部件，所述Z轴支持架的底部设有与驱动压电部件相接触的镜头加力板，所述镜头加力板上旋转设有自动物镜轮，所述自动物镜轮上设有与激光筒相通的至少一个镜头，所述镜头加力板的侧部设有与自动物镜轮轴向连接的第二伺服电机；
所述拍摄支架下方的基准底板上设有盛油槽，所述盛油槽的顶部设有与镜头相应的光源；
所述基准底板上部设有Y轴平移装置，所述Y轴平移装置的顶部设有X轴平移装置，所述X轴平移装置的顶部设有载玻片架和载玻片架垂直调节装置。
作为改进，所述镜头的数量为一个。
作为改进，所述X轴平移装置包括X轴支架,所述X轴支架上滑动设有与载玻片架相连接的固定板，所述X轴支架侧部设有通过柔软连接绳与固定板轴向相连的第三伺服电机，所述X轴支架顶部还设有调节柔软连接绳松紧度的调节器，所述柔软连接绳为钢丝绳。
作为改进，所述Y轴平移装置包括滑动设置在基准底板上的移动板和被动驱动支架，所述被动驱动 支架的两端分别设有紧靠移动板侧部的限位杆，所述基准底板上设有与移动板相应的限位块，所述被动驱动支架的顶部与X轴支架相固定，所述两根限位杆靠近移动板的侧面上均与移动板相接触的万向轮。
作为改进，所述驱动压电部件的竖直方向加力工件是材质为压电陶瓷的大推力压电堆，所述驱动压电部件的检测工件为0.1um精度光栅尺，所述驱动压电部件的控制电源采用材质为压电陶瓷的大推力压电堆、0.1um精度光栅尺和镜头加力板形成了一个闭环系统，所述材质为压电陶瓷的大推力压电堆以每秒0.2um以内精度以600HZ频率做往复运动。
作为改进，所述自动物镜轮和至少一个镜头的重量之和为5KG。
作为改进，所述X轴固定板的平移速度为300mm每秒，所述载玻片架在固定板平移过程中因震动而引起的高度误差在0.2um以内。
本发明与现有技术相比的优点在于：本发明通过上述技术方案，对驱动压电部件通电，大推力压电堆会在沿Z轴(即竖直方向)进行加力，且大推力压电堆与0.1um精度光栅尺形成了一个闭环系统，控制重量为5KG的自动物镜轮与镜头以每秒0.2um以内精度以600HZ频率做往复运动，实现扫描功能，提高了竖直方向加力，镜头上下震荡扫描焦距增加，提高了成像清晰度；调节器能提高X轴方向移动的精度，万向轮能消除Z轴方向力，防止了在移动过程中，传统的传动方式下出现的震动传递到Y轴平移装置和X轴平移装置上，保证了机器在X轴以30mm/秒扫描过程中，镜头与玻片之间的因为震动而引起的高度误差在0.2um以内，进而提高了成像的位置精度。
附图说明
图1是本发明的结构示意图。
图2是本发明中A处的放大结构示意图。
如图所示：1.基准底板 2.Z轴支持架 21.第一伺服电机 22.拍摄支架 23.激光筒 24.镜筒 25.相机 3.驱动压电部件 31.镜头加力板 32.自动物镜轮 33.镜头 34.第二伺服电机 4.盛油槽 41.光源5.Y轴平移装置 51.移动板 52.限位杆 6.X轴平移装置 62.固定板 63.X轴支架 64.柔软连接绳 65.调节器 7.载玻片架 71.载玻片架垂直调节装置。
具体实施方式
下面结合附图对本发明做进一步的详细说明。
本发明在具体实施时，一种细胞检测显微镜，包括基准底板1，所述基准底板1顶部一侧设有Z轴支持架2，所述Z轴支持架2的顶部设有第一伺服电机21，所述Z轴支持架2内旋转设有与第一伺服电机21轴向相连的丝杆，所述丝杆上滑动套接有拍摄支架22，所述拍摄支架22的顶部设有激光筒23，所述激光筒23的顶部设有与激光筒23相连通的镜筒24，所述镜筒24的顶部设有与其相连通的相机25；
所述激光筒23侧部的Z轴支持架2上设有驱动压电部件3，所述Z轴支持架2的底部设有与驱动压电部件3相接触的镜头加力板31，所述镜头加力板31上旋转设有自动物镜轮32，所述自动物镜轮32上 设有与激光筒23相通的至少一个镜头33，所述镜头加力板31的侧部设有与自动物镜轮32轴向连接的第二伺服电机34；
所述拍摄支架22下方的基准底板1上设有盛油槽4，所述盛油槽4的顶部设有与镜头33相应的光源41；
所述基准底板1上部设有Y轴平移装置5，所述Y轴平移装置5的顶部设有X轴平移装置6，所述X轴平移装置6的顶部设有载玻片架7和载玻片架垂直调节装置71。
所述镜头33的数量为一个，所述X轴平移装置6包括X轴支架63,所述X轴支架63上滑动设有与载玻片架7相连接的固定板62，所述X轴支架63侧部设有通过柔软连接绳64与固定板62轴向相连的第三伺服电机，所述X轴支架63顶部还设有调节柔软连接绳64松紧度的调节器65，所述柔软连接绳64为钢丝绳。
所述Y轴平移装置5包括滑动设置在基准底板1上的移动板51和被动驱动支架，所述被动驱动支架的两端分别设有紧靠移动板51侧部的限位杆52，所述基准底板1上设有与移动板51相应的限位块，所述被动驱动支架的顶部与X轴支架63相固定，所述两根限位杆52靠近移动板51的侧面上均与移动板51相接触的万向轮。
所述驱动压电部件3的竖直方向加力工件是材质为压电陶瓷的大推力压电堆，所述驱动压电部件3的检测工件为0.1um精度光栅尺，所述驱动压电部件3的控制电源采用材质为压电陶瓷的大推力压电堆、0.1um精度光栅尺和镜头加力板31形成了一个闭环系统，所述材质为压电陶瓷的大推力压电堆以每秒0.2um以内精度以600HZ频率做往复运动。
所述自动物镜轮32和至少一个镜头33的重量之和为5KG。
所述X轴固定板62的平移速度为30mm每秒，所述载玻片架7在固定板62平移过程中因震动而引起的高度误差在0.2um以内。
其中，对驱动压电部件3通电，大推力压电堆会在沿Z轴(即竖直方向)进行加力，且大推力压电堆与0.1um精度光栅尺形成了一个闭环系统，控制重量为5KG的自动物镜轮32与镜头33以每秒0.2um以内精度以600HZ频率做往复运动，实现扫描功能，提高了竖直方向加力，镜头上下震荡扫描焦距增加，提高了成像清晰度；调节器65能提高X轴方向移动的精度，万向轮能消除Z轴方向力，防止了在移动过程中，传统的传动方式下出现的震动传递到Y轴平移装置和X轴平移装置上，保证了机器在X轴以30mm/秒扫描过程中，镜头与玻片之间的因为震动而引起的高度误差在0.2um以内，进而提高了成像的位置精度。
以上就是一种细胞检测显微镜的结构特点和作用效果，其优点：提高了竖直方向加力，提高了成像清晰度，提高了成像的位置精度。
以上对本发明及其实施方式进行了描述，这种描述没有限制性，附图中所示的也只是本发明的实施方式之一，实际的结构并不局限于此。总而言之如果本领域的普通技术人员受其启示，在不脱离本发明创造 宗旨的情况下，不经创造性的设计出与该技术方案相似的结构方式及实施例，均应属于本发明的保护范围。

Claims (7)

  1. 一种细胞检测显微镜，包括基准底板(1)，其特征在于：所述基准底板(1)顶部一侧设有Z轴支持架(2)，所述Z轴支持架(2)的顶部设有第一伺服电机(21)，所述Z轴支持架(2)内旋转设有与第一伺服电机(21)轴向相连的丝杆，所述丝杆上滑动套接有拍摄支架(22)，所述拍摄支架(22)的顶部设有激光筒(23)，所述激光筒(23)的顶部设有与激光筒(23)相连通的镜筒(24)，所述镜筒(24)的顶部设有与其相连通的相机(25)；
    所述激光筒(23)侧部的Z轴支持架(2)上设有驱动压电部件(3)，所述Z轴支持架(2)的底部设有与驱动压电部件(3)相接触的镜头加力板(31)，所述镜头加力板(31)上旋转设有自动物镜轮(32)，所述自动物镜轮(32)上设有与激光筒(23)相通的至少一个镜头(33)，所述镜头加力板(31)的侧部设有与自动物镜轮(32)轴向连接的第二伺服电机(34)；
    所述拍摄支架(22)下方的基准底板(1)上设有盛油槽(4)，所述盛油槽(4)的顶部设有与镜头(33)相应的光源(41)；
    所述基准底板(1)上部设有Y轴平移装置(5)，所述Y轴平移装置(5)的顶部设有X轴平移装置(6)，所述X轴平移装置(6)的顶部设有载玻片架(7)和载玻片架垂直调节装置(71)。
  2. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述镜头(33)的数量为一个。
  3. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述X轴平移装置(6)包括X轴支架(63)，所述X轴支架(63)上滑动设有与载玻片架(7)相连接的固定板(62)，所述X轴支架(63)侧部设有通过柔软连接绳(64)与固定板(62)轴向相连的第三伺服电机，所述X轴支架(63)顶部还设有调节柔软连接绳(64)松紧度的调节器(65)，所述柔软连接绳(64)为钢丝绳。
  4. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述Y轴平移装置(5)包括滑动设置在基准底板(1)上的移动板(51)和被动驱动支架，所述被动驱动支架的两端分别设有紧靠移动板(51)侧部的限位杆(52)，所述基准底板(1)上设有与移动板(51)相应的限位块，所述被动驱动支架的顶部与X轴支架(63)相固定，所述两根限位杆(52)靠近移动板(51)的侧面上均与移动板(51)相接触的万向轮。
  5. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述驱动压电部件(3)的竖直方向加力工件是材质为压电陶瓷的大推力压电堆，所述驱动压电部件(3)的检测工件为0.1um精度光栅尺，所述驱动压电部件(3)的控制电源采用材质为压电陶瓷的大推力压电堆、0.1um精度光栅尺和镜头加力板(31)形成了一个闭环系统，所述材质为压电陶瓷的大推力压电堆以每秒0.2um以内精度以600HZ频率做往复运动。
  6. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述自动物镜轮(32)和至少一个镜头(33)的重量之和为5KG。
  7. 根据权利要求1所述的一种细胞检测显微镜，其特征在于：所述X轴固定板(62)的平移速度为 30mm每秒，所述载玻片架(7)在固定板(62)平移过程中因震动而引起的高度误差在0.2um以内。
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