WO2020147811A1

WO2020147811A1 - Integrity detection system and method for freeze dryer filter

Info

Publication number: WO2020147811A1
Application number: PCT/CN2020/072677
Authority: WO
Inventors: 李兴波; 俞军; 向湘林; 谭亮
Original assignee: 楚天科技股份有限公司
Priority date: 2019-01-18
Filing date: 2020-01-17
Publication date: 2020-07-23
Also published as: CN109580126A

Abstract

An integrity detection system and method for a freeze dryer (1) filter (2). The detection system comprises a water supply assembly (3) used for supplying water to the filter (2) until the filter (2) is filled with water; a first pressurization assembly (4) used for inflating compressed gas to the filter (2) filled with water to a preset pressure and maintaining the pressure for a preset period of time; and a detection assembly (5) used for detecting pressure values of the pressure of the filter (2) before and after the preset pressure-maintaining period of time to determine whether the filter (2) is normal or not. The integrity detection system for a freeze dryer (1) filter (2) has the advantages of simple structure and low cost. The detection method comprises: S01, a water supply assembly (3) supplies water to the filter (2) until the filter (2) is filled with water; S02, a first pressurization assembly (4) inflates compressed gas to the filter (2) filled with water to a preset pressure and maintains the pressure for a preset period of time; and S03, a detection assembly (5) detects pressure values of the pressure of the filter (2) before and after the preset pressure-maintaining period of time to determine whether the filter (2) is normal or not. The integrity detection method for a freeze dryer (1) filter (2) has the advantages of simple operation.

Description

Integrity detection system and method of freeze dryer filter

Technical field

The invention mainly relates to the technical fields of food and medical packaging, and particularly refers to a system and method for detecting the integrity of the filter of a freeze dryer.

Background technique

During the freeze-drying process of the freeze-drying machine, sterile gas needs to be input into the freeze-drying box through the filter box. Therefore, the quality of the filter element directly affects the freeze-drying operation, and then it is difficult for the operator to distinguish the quality of the filter element However, the current way of performing integrity detection through an integrity detector is not only cumbersome to operate, but also requires higher operators, and the detector has a complex structure, high cost and inconvenient operation.

technical problem

The technical problem to be solved by the present invention lies in: in view of the technical problems existing in the prior art, the present invention provides a freeze dryer filter integrity detection system with simple overall structure and low cost, and accordingly provides a simple operation Detection method.

Technical solution

In order to solve the above technical problems, the technical solution proposed by the present invention is:

An integrity detection system for a freeze dryer filter, including

The water supply component is used to supply water to the filter of the freeze dryer until the filter is filled with water;

The first pressurizing component is used to fill the water-filled filter with compressed gas to a preset pressure, and then maintain the pressure for a preset time period;

The detection component is used to detect the pressure value of the filter pressure before and after the pre-set time period of pressure holding, and compare to determine whether the filter is normal.

As a further improvement of the above technical solution:

The water supply assembly includes a condenser and a cooling coil, the inlet of the condenser is connected with pure steam, and the cooling coil is installed in the condenser for cooling the pure steam into water; The outlet is connected to the inlet of the filter.

The inlet of the condenser is connected with a second pressurizing component, which is used to press the water in the condenser into the filter shell of the filter.

The detection system further includes a pressure relief component, the pressure relief component includes a pressure relief pipe and a pressure relief valve, one end of the pressure relief pipe is connected to the inlet of the filter, and the pressure relief valve is installed in the relief valve. Press the tube.

The first pressurizing assembly includes a pressurizing pipe and a compressed air source. One end of the pressurizing pipe is connected to the compressed air source, and the other end is connected to the filter housing of the filter; the pressurizing pipe is provided with On-off valve for on-off control of pipelines.

An expansion cavity is provided on the pressurizing pipeline.

The detection assembly includes a pressure detection component installed on the pressurized pipeline for detecting the pressure in the pressurized pipeline.

A temperature detection element is arranged on the pressurized pipeline for detecting the temperature in the pressurized pipeline.

The present invention also correspondingly discloses a detection method based on the integrity detection system of the freeze dryer filter as described above, including the following steps:

S01. Use the water supply component to supply water to the filter of the freeze dryer until the filter is filled with water;

S02, pressurize the filter filled with water to a preset pressure through the first pressurizing component, and then maintain the pressure for a preset time period;

S03. Detect the pressure value of the filter pressure before and after the pressure-holding preset time period through the detection component, and compare to determine whether the filter is normal.

As a further improvement of the above technical solution:

In step S03, the temperature value of the filter pressure before and after the pressure holding preset time period is detected, and the pressure value is checked. To

Beneficial effect

Compared with the prior art, the advantages of the present invention are:

The integrity detection system of the freeze dryer filter of the present invention realizes water injection into the filter through the water supply component, and pressurizes and maintains the filter after it is filled with water. By detecting the pressure change before and after the pressurization and maintenance, Determine whether the filter is abnormal (such as a large pressure change, it means the filter is abnormal); the overall structure is simple, low cost and easy to operate.

In the integrity detection system of the freeze dryer filter of the present invention, the water supply component uses the pure steam commonly used in the freeze dryer system to obtain water for detection, further reducing the cost; in addition, it also detects the temperature before and after the pressurization and maintenance, so as to compare the pressure , Convert each pressure to the pressure value at the same temperature, so as to ensure the accuracy of pressure comparison.

The integrity detection method of the freeze dryer filter of the present invention also has the advantages of the above detection system, and is easy to operate and has low requirements for operators.

BRIEF DESCRIPTION

Figure 1 is a schematic diagram of the structure of the present invention.

The signs in the figure indicate: 1. Freeze dryer; 101, box; 2. Filter; 201, filter element; 202, filter housing; 3. Water supply component; 301, condenser; 302, cooling coil; 3021, eighth Solenoid valve; 303, first solenoid valve; 304, second solenoid valve; 305, second pressurizing component; 3051, third solenoid valve; 3052, fifth solenoid valve; 4. first pressurizing component; 401, plus Pressure pipeline; 402, sixth solenoid valve; 403, seventh solenoid valve; 404, expansion chamber; 5. detection component; 501, pressure detection component; 502, temperature detection component; 6. pressure relief component; 601, pressure relief pipe ; 602, the fourth solenoid valve; 7, the ninth solenoid valve.

Embodiments of the invention

The present invention will be further described below with reference to the drawings and specific embodiments of the specification.

As shown in Figure 1, the integrity detection system of the freeze dryer filter of this embodiment includes a water supply component 3 for supplying water to the filter 2 of the freeze dryer 1 until the filter 2 is filled with water; The pressure component 4 is used to fill the water-filled filter 2 with compressed gas to a preset pressure, and then the pressure is maintained for a preset time period; the detection component 5 is used to detect the pressure of the filter 2 before and after the pressure-holding preset time period Pressure value, and compare to determine whether the filter 2 is normal. The integrity detection system of the filter 2 of the freeze dryer of the present invention can determine the inside of the filter 2 by filling, pressurizing and maintaining the inside of the filter 2, and comparing the pressure values before and after the pre-set time period of holding the pressure. The integrity of the filter element 201, compared with the existing complex and expensive detection devices, the detection system of the present invention has a simple overall structure and low cost, and is easy to operate.

In this embodiment, the water supply assembly 3 includes a condenser 301 and a cooling coil 302. The inlet of the condenser 301 is connected with pure steam through a pipe. The pipe is provided with a first solenoid valve 303 for controlling the on and off of the pipe; the cooling coil 302 Installed in the condenser 301 to cool pure steam into water (pure steam is easier to obtain in a freeze-drying system). Specifically, one end of the cooling coil 302 is a cooling water inlet, and the other end is a cooling water outlet. An eighth solenoid valve 3021 is provided at the cooling water inlet; the outlet of the condenser 301 is connected to the inlet of the filter 2 through a pipeline, and the pipeline is provided with a second solenoid valve 304 for controlling the on-off of the pipeline. In addition, the inlet of the condenser 301 is connected with a second pressurizing component 305 for pressing the water in the condenser 301 into the filter housing 202 of the filter 2, wherein the second pressurizing component 305 includes a compressed air source, which compresses The air source is connected to the condenser 301 through a pipe, and a third solenoid valve 3051 is provided on the pipe. In addition, a fifth solenoid valve 3052 is connected to the top of the filter housing 202 of the filter 2 through a pipe; the second pressurizing component 305 adds water Squeeze into the filter housing 202 of the filter 2, and then reach the fifth solenoid valve 3052 (because the filter housing 202 is blocked by the filter element 201, the condensed water cannot pass through the bottom pipeline), close the fifth solenoid valve at this time 3052 and the second solenoid valve 304 perform subsequent pressurization operations.

In this embodiment, the first pressurizing assembly 4 includes a pressurizing pipe 401 and a compressed air source. One end of the pressurizing pipe 401 is connected to the compressed air source, and the other end is connected to the filter housing 202 of the filter 2; There is an on-off valve for on-off control of the pressurized pipeline 401 (the sixth solenoid valve 402 in FIG. 1). In addition, the detecting assembly 5 includes a pressure detecting member 501 (PT1 in FIG. 1) installed on the pressurizing pipe 401 for detecting the pressure in the pressurizing pipe 401. A temperature detecting member 502 is also provided on the pressurizing pipe 401 for detecting the temperature in the pressurizing pipe 401. After the filter housing 202 is filled with water and the corresponding solenoid valve is closed, the filter 2 is inflated and pressurized by the compressed air source through the pressurizing pipe 401 until the pressure detection element 501 detects that the pressure rises to N times the atmospheric pressure (such as 2 When the pressure is increased, the sixth solenoid valve 402 is closed to perform pressure maintaining operation. In addition, an expansion cavity 404 is provided on the pressurized pipeline 401 to avoid obvious pressure fluctuations and ensure the accuracy of detection.

In this embodiment, the detection system further includes a pressure relief assembly 6. The pressure relief assembly 6 includes a pressure relief pipe 601 and a pressure relief valve (the fourth solenoid valve 602 in Figure 1). One end of the pressure relief pipe 601 and the filter 2 The inlet is connected, and the pressure relief valve is installed on the pressure relief pipe 601. After the test is completed, the fourth solenoid valve 602 is opened to release the condensed water inside the filter 2.

In this embodiment, the on-off valves are not limited to solenoid valves. In other embodiments, other automatic control valves without manual intervention can also be used.

The present invention also discloses a freeze-drying machine, which includes a box body 101 and a filter 2. The box body 101 and the filter 2 are connected by a pipeline, and the pipeline is provided with an on-off valve for controlling the on and off of the pipeline (as shown in Figure 1 The seventh solenoid valve 403); the filter 2 is connected with the integrity detection system of the freeze dryer filter as described above. The freeze dryer of the present invention also has the advantages of the above detection system, and has a simple structure and easy realization.

The invention also discloses a detection method based on the integrity detection system of the freeze dryer filter as described above, which includes the following steps:

S01. The water supply component 3 is used to supply water to the filter 2 of the freeze dryer 1 until the filter 2 is filled with water;

S02, pressurize the filter 2 filled with water to a preset pressure through the first pressurizing component 4, and then maintain the pressure for a preset time period;

S03. Detect the pressure value of the filter 2 before and after the pressure-holding preset time period through the detection component 5, and compare to determine whether the filter 2 is normal.

In this embodiment, in step S03, the temperature value of the pressure of the filter 2 before and after the pressure-holding preset period of time is detected, the pressure value is calibrated, and each pressure value is converted into a pressure value at the same temperature to ensure the pressure comparison The precision.

The detection method of the present invention will be further described below in conjunction with the detection system of the present invention:

In normal operation, the gas enters the filter 2 through the ninth solenoid valve 7 and enters the freeze dryer through the seventh solenoid valve 403 through the filtering effect of the filter element 201 to ensure the sterile and clean characteristics of the gas in the freeze dryer.

During the test, the ninth solenoid valve 7 is closed, and the pure steam is condensed into water by the cooling coil 302 in the condenser 301, and then pressurized by the second pressurizing component 305 to press the condensed water into the filter 2 until The filter housing 202 of the filter 2 is filled with water until it overflows to the fifth solenoid valve 3052, and then the fifth solenoid valve 3052 and the second solenoid valve 304 are closed (at this time, the fourth solenoid valve 602 and the seventh solenoid valve 403 are both in Disabled);

Open the sixth solenoid valve 402, and fill the filter housing 202 with pressurized air until the pressure detection element 501 detects that the pressure reaches N times the atmospheric pressure, stop pressurizing, and close the sixth solenoid valve 402. Device 2 performs pressure maintaining operation for a preset time (such as 30min);

Turn on automatic detection and analysis, the pressure detection part 501 and the temperature detection part 502 perform real-time detection, and record the pressure (P start and P end) and temperature (T start and T end) at the start and end time points of the preset time period. It can be judged whether the filter element 201 in the filter 2 is intact by manually or automatically calculating the ratio R of the time to the pressure change value by manual or PLC. Since the filter element 201 in the filter 2 is a hydrophobic filter element, the air is not watery, and when the filter element 201 is damaged, the pressure change value will increase, that is, R will decrease, so that it is judged that the filter element 201 is damaged. Of course, in order to avoid the influence of ambient temperature on pressure, when performing pressure comparison, each pressure value is converted to a pressure value at the same temperature to ensure the accuracy of the pressure comparison.

The above are only the preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments. All technical solutions under the idea of the present invention belong to the protection scope of the present invention. It should be noted that for those of ordinary skill in the art, several improvements and modifications without departing from the principle of the present invention should be regarded as the protection scope of the present invention.

Claims

An integrity detection system for a freeze dryer filter, which is characterized in that it comprises

The water supply component (3) is used to supply water to the filter (2) of the freeze dryer (1) until the filter (2) is filled with water;

The first pressurizing component (4) is used to fill the water-filled filter (2) with compressed gas to a preset pressure, and then maintain the pressure for a preset time period;

The detection component (5) is used to detect the pressure value of the filter (2) before and after the pressure-holding preset time period, and compare to determine whether the filter (2) is normal.
The integrity detection system of the freeze dryer filter according to claim 1, wherein the water supply component (3) includes a condenser (301) and a cooling coil (302), and the condenser (301) The inlet of the condenser (301) is connected with pure steam, the cooling coil (302) is installed in the condenser (301) for cooling the pure steam into water; the outlet of the condenser (301) is connected to the filter (2) ) Imports.
The integrity detection system of the freeze dryer filter according to claim 2, wherein the inlet of the condenser (301) is connected with a second pressurizing component (305) for connecting the condenser (301) The water inside is pressed into the filter housing (202) of the filter (2).
The integrity detection system of the freeze dryer filter according to claim 2 or 3, characterized in that it further comprises a pressure relief component (6), and the pressure relief component (6) includes a pressure relief pipe (601) and a relief A pressure valve, one end of the pressure relief pipe (601) is connected to the inlet of the filter (2), and the pressure relief valve is installed on the pressure relief pipe (601).
The integrity inspection system of the freeze dryer filter according to any one of claims 1 to 3, characterized in that the first pressurizing component (4) comprises a pressurized pipe (401) and a compressed air source, One end of the pressurizing pipe (401) is connected to a compressed air source, and the other end is connected to the filter housing (202) of the filter (2); the pressurizing pipe (401) is provided with a pressurizing pipe (401) On-off valve for on-off control.
The integrity detection system of the freeze dryer filter according to claim 5, characterized in that an expansion cavity (404) is provided on the pressurized pipeline (401).
The integrity detection system of the freeze dryer filter according to claim 5, characterized in that the detection component (5) comprises a pressure detection component (501) installed on the pressurized pipeline (401), To detect the pressure in the pressurized pipeline (401).
The integrity detection system of the freeze dryer filter according to claim 7, characterized in that, a temperature detection element (502) is provided on the pressurized pipeline (401), which is used for detecting the inside of the pressurized pipeline (401). The temperature is detected.
A detection method based on the integrity detection system of the freeze dryer filter according to any one of claims 1 to 8, characterized in that it comprises the following steps:

S01. Use the water supply component (3) to supply water to the filter (2) of the freeze dryer (1) until the filter (2) is filled with water;

S02, pressurize the water-filled filter (2) to a preset pressure through the first pressurizing component (4), and then maintain the pressure for a preset time period;

S03. Detect the pressure value of the filter (2) before and after the pressure-holding preset time period through the detection component (5), and compare to determine whether the filter (2) is normal.
The detection method according to claim 9, characterized in that, in step S03, the temperature value of the pressure of the filter (2) before and after the pressure-holding preset time period is detected, and the pressure value is checked.