CN107289984A - One kind is used for sterilizing cabinet filter integrity online verification system and its detection method - Google Patents
One kind is used for sterilizing cabinet filter integrity online verification system and its detection method Download PDFInfo
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- CN107289984A CN107289984A CN201610226587.7A CN201610226587A CN107289984A CN 107289984 A CN107289984 A CN 107289984A CN 201610226587 A CN201610226587 A CN 201610226587A CN 107289984 A CN107289984 A CN 107289984A
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- valve body
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- sterilizing cabinet
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
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Abstract
It is of the invention a kind of for sterilizing cabinet filter integrity online verification system and its detection method, it is characterised in that to comprise the following steps：Step S10：The first valve body, the 3rd valve body, the 4th valve body and the 5th valve body are closed, the injection that the second valve body makes feed tube carry out immersion fluid to the cavity in filtrate housing is opened；Step S20：Fill and the second valve body is closed after immersion fluid, cavity is pressed by compressed air input pipe, and the pressure in cavity is detected by detection means；Step S30：Open detection of the 3rd valve body progress to filtration core；Step S40：After the completion of detection, open the 4th valve body and the immersion fluid in cavity is discharged.By using of the invention a kind of for sterilizing cabinet filter integrity online verification system and its detection method, it is to avoid the online checking to filtration core integrality is realized in dismounting, and its is simple in construction, it is easy to manufactures, install.
Description
Technical field
The present invention relates to sterilizing cabinet equipment filtrate housing detection technique field, and in particular to one kind is used for sterilizing cabinet filter integrity online verification system and its detection method.
Background technology
It is well known that the xeothermic effect of sterilizing cabinet is applied to cillin bottle, ampoule bottle, Aluminum Bottle, metal and glassware article sterilizing pyrogen removal and the solid material hot air sterilization of pharmaceutical chemical industry food service industry.At present, sterilizing cabinet is in negative pressure state in equipment after vaporizing and drying, now needs to pour filtrated air balance external and internal pressure, the quality of filtrated air is ensured by filtrated air filtrate housing on admission line, then the integrality of filtrate housing, which just must verify that, to be used.The detection for sterilizing cabinet filtrate housing is off-line operation in the prior art, and the off-line operation is：Filtrate housing is pulled down to be placed in inspection equipment out of sterilizing cabinet and individually detected.Such operation is cumbersome, and can take the substantial amounts of time, if long-term so operation can cause irreversible damage to filtrate housing.
The content of the invention
The application provides a kind of for sterilizing cabinet filter integrity online verification system and its detection method, it is complicated for filtrate housing check problem in sterilizing cabinet in the prior art to solve, the problem of causing waste of time, and irreversible damage can be caused to filtrate housing in itself.
To achieve the above object, the technical solution adopted by the present invention is：
One kind is used for sterilizing cabinet filter integrity online verification system, including filtrate housing and the filtration core for being fixed on the filtrate housing bottom surface, wherein, including：Sterile air inlet pipe, sterile escape pipe, feed tube, drain pipe, compressed air input pipe；
The bottom surface of the output end of the sterile air inlet pipe through the filtrate housing is connected with the inner chamber of the filtrate housing, and the first valve body is provided with the sterile air inlet pipe；
The input of the sterile escape pipe is connected through the bottom surface of the filtrate housing with the filtration core, and first row water pipe is equipped with outside the middle part of the sterile escape pipe；
The top surface of the output end of the compressed air input pipe through the filtrate housing is connected with the inner chamber of the filtrate housing, the input of the compressed air input pipe is connected to detection means, the drain pipe is equipped with outside the middle part of the compressed air input pipe, the input of the drain pipe is connected with the compressed air input pipe；
The output end of the feed tube is connected with the sterile air inlet pipe, and the second valve body is provided with the feed tube.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system, wherein, air filtration and purification apparatus is provided with the compressed air input pipe.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system, wherein, the 3rd valve body is provided with first drainpipe.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system, wherein, the bottom surface of the filtrate housing connects the second drainpipe；
The 4th valve body is provided with second drainpipe；
The output end of second drainpipe and the output end of first drainpipe are all connected to main sewer.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system, wherein, the 5th valve body is provided with the drain pipe.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system, wherein, first valve body, second valve body, the 3rd valve body, the 4th valve body and the 5th valve body, are check valve.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system and its detection method and its detection method, wherein, comprise the following steps：
Step S10：First valve body, the 3rd valve body, the 4th valve body and the 5th valve body are closed, the injection that second valve body makes the feed tube carry out immersion fluid to the cavity in the filtrate housing is opened；
Step S20：Fill and second valve body is closed after immersion fluid, the cavity is pressed by the compressed air input pipe, and the pressure in the cavity is detected by the detection means；
Step S30：Open detection of the 3rd valve body progress to the filtration core；
Step S40：After the completion of detection, open the 4th valve body and the immersion fluid in the cavity is discharged.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system and its detection method, wherein, in the step S30, it is to detect the filtration core, the detection means detects that the pressure in the cavity reduces the then filtration core and is damaged, and the detection means detects the pressure in the cavity, and for steady state value, then the filtration core is intact.
Above-mentioned is used for sterilizing cabinet filter integrity online verification system and its detection method, wherein, in the step S10,5th valve body is opened, after the immersion fluid in the cavity flows out the drain pipe, then judge to be filled by immersion fluid in the cavity, second valve body and the 5th valve body are then closed successively.
One kind according to above-described embodiment is used for sterilizing cabinet filter integrity online verification system and its detection method, and the program has following effect：
1st, dismounting is avoided to realize the online checking to filtration core integrality；
2nd, its is simple in construction, it is easy to manufactures, install.
Brief description of the drawings
Fig. 1 is a kind of structural representation for sterilizing cabinet filter integrity online verification system；
Fig. 2 is used for sterilizing cabinet filter integrity online verification system and its detection method schematic flow sheet to be a kind of.
Such as scheme reference：Filtrate housing 1, filtration core 2, sterile air inlet pipe 3, sterile escape pipe 4, feed tube 5, drain pipe 6, compressed air input pipe 7, inner chamber 8, detection means 9, the first drainpipe 10, the first valve body 11, the second valve body 12, the 3rd valve body 13, the 5th valve body 15, air filtration and purification apparatus 16, the second drainpipe 17, main sewer 18.
Embodiment
In order that technological means, creation feature, reached purpose and effect that invention is realized are easy to understand, lower combination is specifically illustrating, and the present invention is expanded on further.
As shown in Figure 1-2, the present invention is a kind of is used for sterilizing cabinet filter integrity online verification system, including filtrate housing 1 and the filtration core 2 for being fixed on the bottom surface of filtrate housing 1, wherein, including：Sterile air inlet pipe 3, sterile escape pipe 4, feed tube 5, drain pipe 6, compressed air input pipe 7, further presence is：Filtrate housing 1 is injected air into by sterile air inlet pipe 3, discharged by the filtering of filtration core 2 by sterile escape pipe 4, further feed tube 5, drain pipe 6 and compressed air input pipe 7 are that filtration core 2 is detected by injecting liquid.
The bottom surface of the output end of sterile air inlet pipe 4 through filtrate housing 1 is connected with the inner chamber 8 of filtrate housing 1, and the first valve body 11 is provided with sterile air inlet pipe 4, further, is opened by the first valve body 11 and is carried out path and open circuit to sterile air inlet pipe 4.
The input of sterile escape pipe 4 is connected through the bottom surface of filtrate housing 1 with filtration core 2, and first row water pipe 10 is equipped with outside the middle part of sterile escape pipe 4；
The top surface of the output end of compressed air input pipe 7 through filtrate housing 1 is connected with the inner chamber 8 of filtrate housing 1, the input of compressed air input pipe 7 is connected to detection means 9, drain pipe 6 is equipped with outside the middle part of compressed air input pipe 7, the input of drain pipe 6 is connected with compressed air input pipe 7；
The output end of feed tube 6 is connected with sterile air inlet pipe 3, and the second valve body 12 is provided with feed tube 5.
In a particular embodiment of the present invention, air filtration and purification apparatus 16 is provided with compressed air input pipe 7, further prevents foreign matter, dust etc. from entering the work load that filtrate housing 1 reduces filtration core 2.
In a particular embodiment of the present invention, the 3rd valve body 13 is provided with the first drainpipe 10, further first drainpipe 10 is used to discharge the liquid oozed out in filtration core 2.
In a particular embodiment of the present invention, the bottom surface of filtrate housing 1 connects the second drainpipe 17；The 4th valve body 14 is provided with second drainpipe 17；The output end of the output end of second drainpipe 17 and the first drainpipe 10 is all connected to main sewer 18, further main sewer 18 together discharges the first drainpipe 10 with the liquid ash machine in the second drainpipe 17, it is to avoid the space-consuming of pipeline.
In a particular embodiment of the present invention, the 5th valve body 15 is provided with drain pipe 6.
In a particular embodiment of the present invention, the first valve body 11, the second valve body 12, the 3rd valve body 13, the 4th valve body 14 and the 5th valve body 15, are check valve.
As shown in Fig. 2 a kind of sterilizing cabinet filter integrity online verification system and its detection method, wherein, comprise the following steps：
Step S10：The first valve body 11, the 3rd valve body 13, the 4th valve body 14 and the 5th valve body 15 are closed, the injection that the second valve body 12 makes feed tube 5 carry out immersion fluid to the cavity 8 in filtrate housing 1 is opened；
Step S20：Fill and the second valve body 12 is closed after immersion fluid, cavity 8 is pressed by compressed air input pipe 7, and the pressure in cavity 8 is detected by detection means 9；
Step S30：Open the 3rd valve body 13 and carry out the detection to filtration core 2；
Step S40：After the completion of detection, open the 4th valve body 14 and the immersion fluid in cavity 8 is discharged.
In a particular embodiment of the present invention, it is that, in order to detect filtration core 2, detection means 9 detects that the pressure in cavity 8 reduces then filtration core 2 and is damaged, and detection means 9 detects the pressure in cavity 8, and for steady state value, then filtration core 2 is intact in step S30；
Filtration core 2 is damaged, and the first drainpipe 10 there are flowing out, caused by the air pressure reduction inside the increase of space in cavity 8, and then detection numerical value is steady state value for the anhydrous outflow of the first drainpipe 10 herein, and the filtration core 2 is intact.
In a particular embodiment of the present invention, in step slo, the 5th valve body 5 is opened, after the immersion fluid in cavity 8 flows out drain pipe 6, then judges to be filled by immersion fluid in cavity 8, the second valve body 12 and the 5th valve body 15 are then closed successively.
In summary, the present invention is a kind of is used for sterilizing cabinet filter integrity online verification system and its detection method, it is to avoid the online checking to filtration core integrality is realized in dismounting, and its is simple in construction, it is easy to manufactures, install.
The specific embodiment of invention is described above.It is to be appreciated that invention is not limited to above-mentioned particular implementation, wherein the equipment and structure be not described in detail to the greatest extent are construed as being practiced with the common mode in this area；Those skilled in the art can make various deformations or amendments within the scope of the claims and make some simple deductions, deformation or replace, and this has no effect on the substantive content of invention.
Claims (9)
1. one kind is used for sterilizing cabinet filter integrity online verification system, including filtrate housing and the filtration core for being fixed on the filtrate housing bottom surface, it is characterised in that including：Sterile air inlet pipe, sterile escape pipe, feed tube, drain pipe, compressed air input pipe；
The bottom surface of the output end of the sterile air inlet pipe through the filtrate housing is connected with the inner chamber of the filtrate housing, and the first valve body is provided with the sterile air inlet pipe；
The input of the sterile escape pipe is connected through the bottom surface of the filtrate housing with the filtration core, and first row water pipe is equipped with outside the middle part of the sterile escape pipe；
The top surface of the output end of the compressed air input pipe through the filtrate housing is connected with the inner chamber of the filtrate housing, the input of the compressed air input pipe is connected to detection means, the drain pipe is equipped with outside the middle part of the compressed air input pipe, the input of the drain pipe is connected with the compressed air input pipe；
The output end of the feed tube is connected with the sterile air inlet pipe, and the second valve body is provided with the feed tube.
2. according to claim 1 be used for sterilizing cabinet filter integrity online verification system, it is characterised in that air filtration and purification apparatus is provided with the compressed air input pipe.
3. according to claim 1 be used for sterilizing cabinet filter integrity online verification system, it is characterised in that the 3rd valve body is provided with first drainpipe.
4. according to claim 1 be used for sterilizing cabinet filter integrity online verification system, it is characterised in that the bottom surface of the filtrate housing connects the second drainpipe；
The 4th valve body is provided with second drainpipe；
The output end of second drainpipe and the output end of first drainpipe are all connected to main sewer.
5. according to claim 4 be used for sterilizing cabinet filter integrity online verification system, it is characterised in that the 5th valve body is provided with the drain pipe.
6. according to claim 5 be used for sterilizing cabinet filter integrity online verification system, it is characterised in that first valve body, second valve body, the 3rd valve body, the 4th valve body and the 5th valve body, are check valve.
7. one kind is used for sterilizing cabinet filter integrity online verification system and its detection method, it is characterised in that comprise the following steps：
Step S10：The first valve body, the 3rd valve body, the 4th valve body and the 5th valve body are closed, the injection that the second valve body makes feed tube carry out immersion fluid to the cavity in filtrate housing is opened；
Step S20：Fill and the second valve body is closed after immersion fluid, cavity is pressed by compressed air input pipe, and the pressure in cavity is detected by detection means；
Step S30：Open detection of the 3rd valve body progress to filtration core；
Step S40：After the completion of detection, open the 4th valve body and the immersion fluid in cavity is discharged.
8. according to claim 7 be used for sterilizing cabinet filter integrity online verification system and its detection method, it is characterized in that, in step S30, it is to detect filtration core, detection means detects that the pressure in cavity reduces then filtration core and is damaged, and detection means detects the pressure in cavity, and for steady state value, then filtration core is intact.
9. according to claim 7 be used for sterilizing cabinet filter integrity online verification system and its detection method, it is characterized in that, in step slo, 5th valve body is opened, after the immersion fluid in cavity flows out drain pipe, then judge to be filled by immersion fluid in cavity, the second valve body and the 5th valve body are then closed successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610226587.7A CN107289984A (en) | 2016-04-13 | 2016-04-13 | One kind is used for sterilizing cabinet filter integrity online verification system and its detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610226587.7A CN107289984A (en) | 2016-04-13 | 2016-04-13 | One kind is used for sterilizing cabinet filter integrity online verification system and its detection method |
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| Publication Number | Publication Date |
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| CN107289984A true CN107289984A (en) | 2017-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610226587.7A Pending CN107289984A (en) | 2016-04-13 | 2016-04-13 | One kind is used for sterilizing cabinet filter integrity online verification system and its detection method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020147811A1 (en) * | 2019-01-18 | 2020-07-23 | 楚天科技股份有限公司 | Integrity detection system and method for freeze dryer filter |
| WO2022007916A1 (en) * | 2020-07-09 | 2022-01-13 | 江苏新美星包装机械股份有限公司 | Online testing method for integrity of sterilizing filter element |
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| CN201732014U (en) * | 2010-08-20 | 2011-02-02 | 伊马莱富（北京）制药系统有限公司 | Online integrity test system of sterile filter |
| CN102435224A (en) * | 2011-11-08 | 2012-05-02 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN104048839A (en) * | 2014-05-26 | 2014-09-17 | 上海东富龙拓溥科技有限公司 | On-line integrity detecting device and method used after fully-automatic sterilization |
| CN203965099U (en) * | 2014-07-07 | 2014-11-26 | 海南通用康力制药有限公司 | Integral filter integrity detection instrument |
| CN204705164U (en) * | 2015-05-20 | 2015-10-14 | 上海翡诺医药设备有限公司 | A kind of for freeze dryer multiple filter of pressing online |
| WO2016045762A1 (en) * | 2014-09-22 | 2016-03-31 | Sartorius Stedim Biotech Gmbh | Device for ventilation and integrity testing |
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2016
- 2016-04-13 CN CN201610226587.7A patent/CN107289984A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201732014U (en) * | 2010-08-20 | 2011-02-02 | 伊马莱富（北京）制药系统有限公司 | Online integrity test system of sterile filter |
| CN102435224A (en) * | 2011-11-08 | 2012-05-02 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN104048839A (en) * | 2014-05-26 | 2014-09-17 | 上海东富龙拓溥科技有限公司 | On-line integrity detecting device and method used after fully-automatic sterilization |
| CN203965099U (en) * | 2014-07-07 | 2014-11-26 | 海南通用康力制药有限公司 | Integral filter integrity detection instrument |
| WO2016045762A1 (en) * | 2014-09-22 | 2016-03-31 | Sartorius Stedim Biotech Gmbh | Device for ventilation and integrity testing |
| CN204705164U (en) * | 2015-05-20 | 2015-10-14 | 上海翡诺医药设备有限公司 | A kind of for freeze dryer multiple filter of pressing online |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020147811A1 (en) * | 2019-01-18 | 2020-07-23 | 楚天科技股份有限公司 | Integrity detection system and method for freeze dryer filter |
| WO2022007916A1 (en) * | 2020-07-09 | 2022-01-13 | 江苏新美星包装机械股份有限公司 | Online testing method for integrity of sterilizing filter element |
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Application publication date: 20171024 |