CN102109364A - Filter integrity detecting system for freeze dryer and detecting method thereof - Google Patents
Filter integrity detecting system for freeze dryer and detecting method thereof Download PDFInfo
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- CN102109364A CN102109364A CN 201010567927 CN201010567927A CN102109364A CN 102109364 A CN102109364 A CN 102109364A CN 201010567927 CN201010567927 CN 201010567927 CN 201010567927 A CN201010567927 A CN 201010567927A CN 102109364 A CN102109364 A CN 102109364A
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Abstract
The invention relates to a filter integrity detecting system for a freeze dryer and a detecting method thereof, wherein the detecting system comprises an integrity detector, an integrity air induction valve, a filter drying valve, an electric heater, a prefilter, a first air release valve, a first filter, a second air release valve, a second filter, a third air release valve and a freeze drying box air release valve which are connected in series and in sequence by pipelines. In the invention, the first filter and the second filter are connected in series, the opening of the devices and the valves in the whole detecting system are controlled by a PLC (programmable logic controller) in an online manner, and the integrity detector judges whether the first filter and the second filter are qualified in real time according to parameters preset by the PLC, so that the real-time monitoring for the filters of the freeze dryer in the whole working process is realized, the safety and reliability of working of the freeze dryer are guaranteed, and simultaneously the aseptic safety for online detection is also guaranteed. Also, in the invention, the operation is simple, and the test result is reliable.
Description
Technical field
The present invention relates to pharmaceutical machine, relate in particular to a kind of filter integrity detection system and detection method thereof that is used for freeze dryer.
Background technology
Owing to import aseptic gas in each stage of freeze-drying process, all needing to freeze drying box, therefore, the filter element that freeze drying box is used to exit fine or not extremely important.Yet operating personnel generally are difficult to differentiate the quality of filter element, so must judge by the filter integrity detector.
Detection mode commonly used now mainly is to adopt the method for offline inspection and online manual detection; Yet than higher, the dismounting of filtrator all needs in the gnotobasis off-line checking method for environmental requirement, and therefore, just there is certain risk in itself; And it is online manual detection method operation more complicated, and also high to operating personnel's requirement.In view of the foregoing, press at present filter integrity checkout equipment and mode are improved.
Summary of the invention
In order to solve the problem that above-mentioned prior art exists, the present invention aims to provide a kind of filter integrity detection system and detection method thereof that is used for freeze dryer, automatic operation with all pick-up units in the realization system, thereby make aseptic security performance height in the online testing process, simple to operate, test findings is reliable.
The described a kind of filter integrity detection system that is used for freeze dryer of one of the present invention, described freeze dryer comprises a freeze drying box, described detection system comprises an integrity detection instrument, integrality air importing valve, the dry valve of a filtrator, an electric heater, a prefilter, first air release, first filtrator, second air release, second filtrator, the 3rd air release and a freeze drying box air release that is connected serially to described freeze drying box by pipeline successively
Described integrity detection instrument is connected with a remote PLC (programmable logic controller (PLC));
The entrance point of described prefilter is connected with a nitrogen supply valve with a dry air supply valve respectively;
The endpiece of described first air release is connected to a drainpipe by the first steam bleeding water valve, the first filtrator draining valve and the first filtrator steam discharge water valve successively;
Described first filtrator is connected with described integrity detection instrument with second isolation valve by first isolation valve respectively with second filtrator, and connect between the entrance point of described first isolation valve and second isolation valve first surplus valve and second surplus valve;
The entrance point of described second air release is connected to described drainpipe by the second steam bleeding water valve and the second filtrator steam discharge water valve successively, the entrance point of the described second filtrator steam discharge water valve is connected between described first surplus valve and second surplus valve, and the endpiece of described second air release is connected to described drainpipe by the 3rd steam bleeding water valve, the second filtrator draining valve and the 3rd filtrator steam discharge water valve successively;
The entrance point of described the 3rd air release is connected to described drainpipe by the 4th steam bleeding water valve and the 4th filtrator steam discharge water valve successively, and its endpiece is connected to described drainpipe by the 5th steam bleeding water valve and the 5th filtrator steam discharge water valve successively;
The endpiece that described integrality air imports valve is connected with a water tower by a water tower pressurizing valve, the endpiece of this water tower is connected with a total feed water valve, the endpiece of this total feed water valve is connected to the entrance point of the described first filtrator draining valve and the entrance point of the second filtrator draining valve by first feed water valve and second feed water valve respectively, and described water tower also is connected with a water tower vent valve.
In the above-mentioned filter integrity detection system that is used for freeze dryer,
Described integrality air imports two pressure regulator valves of connecting between valve and the water tower pressurizing valve;
The entrance point of described dry air supply valve and nitrogen supply valve connect respectively a pressure regulator valve and a manual ball valve, their endpiece is respectively equipped with a flow control valve, and between two pressure regulator valves that the entrance point of the pressure regulator valve that is connected with described dry air supply valve is connected to described water tower pressurizing valve is connected;
The entrance point of described first to the 5th filtrator steam discharge water valve is respectively equipped with a flow control valve, and the import and export end of described first to the 5th a filtrator steam discharge water valve difference flow control valve in parallel;
The entrance point of described first filtrator advances steam valve with a filtrator respectively and is connected with a pressure unit;
The endpiece of described the 3rd air release also is connected with a condenser air release;
The endpiece of described the 4th steam bleeding water valve is connected with a temperature detecting resistance;
The import and export end of a described freeze drying box air release aeration valve in parallel and the aeration operation valve of connecting with this aeration valve;
Be provided with a flow control valve between the endpiece of described water tower and the total feed water valve.
In the above-mentioned filter integrity detection system that is used for freeze dryer, described drainpipe is provided with a draining valve.
Two described a kind of detection methods of the present invention based on above-mentioned detection system, it may further comprise the steps:
Reveal and check step, described PLC controls second air release and opens, whether described integrity detection instrument check test pressure is stable, if, the dry valve of then described PLC controlled filter device and first air release are opened, otherwise, reveal and check the step interruption, described PLC reports to the police, and repeats to reveal behind abnormal restoring to check step;
The moistening step of first filtrator, described PLC control freeze drying box air release, second, third air release, first feed water valve, first, second steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened, behind moistening the finishing of described first filtrator, described PLC controls first surplus valve, the first filtrator steam discharge water valve and the first filtrator draining valve and opens;
First filtrator detects preparation process, and described PLC control freeze drying box air release, second, third air release, first isolation valve, first surplus valve and water tower air release are opened;
First filtrator detects step, described PLC control freeze drying box air release, second, third air release, first isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, described integrity detection instrument detects the integrality of first filtrator, and to PLC output testing result, when this testing result is first filtrator when qualified, then carry out first filtrator and detect completing steps, otherwise, described PLC reports to the police, and carries out first filtrator and detect interrupt step;
First filtrator detects completing steps, and described PLC control freeze drying box air release, second, third air release, first surplus valve and the first filtrator draining valve are opened, and carry out the moistening step of second filtrator or the first filtrator drying steps;
First filtrator detects interrupt step, and described PLC control freeze drying box air release and second, third air release are opened, and carry out the moistening step of second filtrator;
The moistening step of second filtrator, described PLC control freeze drying box air release, the 3rd air release, second feed water valve, second, third steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened, behind moistening the finishing of described second filtrator, described PLC controls second surplus valve, the 4th filtrator steam discharge water valve, the 4th steam bleeding water valve and the second filtrator draining valve and opens;
Second filtrator detects preparation process, and described PLC control freeze drying box air release, the 3rd air release, second isolation valve, second surplus valve and water tower air release are opened;
Second filtrator detects step, described PLC control freeze drying box air release, the 3rd air release, second isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, described integrity detection instrument detects the integrality of second filtrator, and to PLC output testing result, when this testing result is second filtrator when qualified, then carry out second filtrator and detect completing steps, otherwise, described PLC reports to the police, and carries out second filtrator and detect interrupt step;
Second filtrator detects interrupt step, described PLC control freeze drying box air release and the 3rd air release are opened, and return once described second filtrator of execution earlier and detect preparation process, when carrying out described second filtrator once more and detect interrupt step, then then carry out first, second filtrator drying steps;
Second filtrator detects completing steps, and described PLC control freeze drying box air release, the 3rd air release, second surplus valve and the second filtrator draining valve are opened, and carry out first, second filtrator drying steps;
First, second filtrator drying steps, described PLC controls second air release and electric heater is opened, after the equal drying of described first, second filtrator finishes, the dry valve of described PLC controlled filter device, first air release, first, second surplus valve, first to fourth filtrator steam discharge water valve, first to fourth steam bleeding water valve and first, second filtrator draining valve are opened, so far, filter integrity detects and finishes;
The first filtrator drying steps, described PLC control electric heater is opened, after the described first filtrator drying finishes, the dry valve of described PLC controlled filter device, first air release, first surplus valve, first, second filtrator steam discharge water valve, first, second steam bleeding water valve and the first filtrator draining valve are opened, so far, filter integrity detects and finishes.
In the detection method of above-mentioned detection system,
In the moistening step of described first filtrator, when the liquid measure in the described water tower reaches the default liquid level intermediate value of described PLC, moistening the finishing of described first filtrator;
In the moistening step of described second filtrator, when the liquid measure in the described water tower reaches the default liquid level lower limit of described PLC, moistening the finishing of described second filtrator.
In the detection method of above-mentioned detection system,
Detect in the step at described first filtrator, described integrity detection instrument detects under preset pressure, the numerical value of the gas by described first filtrator in the unit interval, when this numerical value reaches the default qualified numerical value of described PLC, described integrity detection instrument judges that first filtrator is qualified, otherwise first filtrator is defective;
Detect in the step at described second filtrator, described integrity detection instrument detects under preset pressure, the numerical value of the gas by described second filtrator in the unit interval, when this numerical value reaches the default qualified numerical value of described PLC, described integrity detection instrument judges that second filtrator is qualified, otherwise second filtrator is defective.
In the detection method of above-mentioned detection system, detect in the completing steps at described first filtrator, before described freeze dryer is carried out the freeze-drying operation, then carry out the moistening step of described second filtrator, after described freeze dryer executes the freeze-drying operation, then carry out the described first filtrator drying steps.
In the detection method of above-mentioned detection system, described detection method also is included in the preliminary step of reveal checking between the step, confirms the liquid measure in the described water tower, and when liquid measure did not reach the default liquid level higher limit of described PLC, described PLC reported to the police.
In the detection method of above-mentioned detection system, carry out in the process of described detection method, not enough or described integrity detection instrument is unusual or during overload, described PLC reports to the police when the dry air that enters or nitrogen pressure; Carry out in the process of the described first filtrator drying steps and first, second filtrator drying steps, when described electric heater was unusual, described PLC reported to the police.
Owing to adopted above-mentioned technical solution, the present invention is by connecting first, second filtrator, and opening by device in the whole detection system of PLC On-line Control and valve, the integrity detection instrument is according to judging in real time by the default parameter of PLC whether first, second filtrator is qualified, thereby realize real-time monitoring to the filter integrity in the freeze dryer entire work process, guaranteed the safe reliability of freeze dryer work, simultaneously, also guaranteed the aseptic security of online detection, the present invention is simple to operate, and test findings is reliable.
Description of drawings
Fig. 1 is a kind of schematic diagram that is used for the filter integrity detection system of freeze dryer of the present invention;
Fig. 2 is a kind of process flow diagram that is used for the filter integrity detection method of freeze dryer of the present invention.
Embodiment
Below in conjunction with accompanying drawing, specific embodiments of the invention are elaborated.
As shown in Figure 1, the present invention, it is a kind of filter integrity detection system that is used for freeze dryer, freeze dryer comprises a freeze drying box 101, detection system comprises integrity detection instrument 1, integrality air importing valve 2, the dry valve 3 of filtrator, electric heater 4, prefilter 5, first air release 6, first filtrator 7, second air release 8, second filtrator 9, the 3rd air release 10 and the freeze drying box air release 11 that is connected serially to freeze drying box 101 by pipeline successively, wherein
Integrity detection instrument 1 is connected with a remote PLC (not shown);
The entrance point of prefilter 5 is connected with nitrogen supply valve 13 with dry air supply valve 12 respectively;
The endpiece of first air release 6 is connected to drainpipe 17 by the first steam bleeding water valve 14, the first filtrator draining valve 15 and the first filtrator steam discharge water valve 16 successively;
First filtrator 7 is connected with integrity detection instrument 1 with second isolation valve 19 by first isolation valve 18 respectively with second filtrator 9, and connect between the entrance point of first isolation valve 18 and second isolation valve 19 first surplus valve 20 and second surplus valve 21;
The entrance point of second air release 8 is connected to drainpipe 17 by the second steam bleeding water valve 22 and the second filtrator steam discharge water valve 23 successively, and the entrance point of the second filtrator steam discharge water valve 23 is connected between first surplus valve 20 and second surplus valve 21, and the endpiece of second air release 8 is connected to drainpipe 17 by the 3rd steam bleeding water valve 24, the second filtrator draining valve 25 and the 3rd filtrator steam discharge water valve 26 successively;
The entrance point of the 3rd air release 10 is connected to drainpipe 17 by the 4th steam bleeding water valve 27 and the 4th filtrator steam discharge water valve 28 successively, and its endpiece is connected to drainpipe 17 by the 5th steam bleeding water valve 29 and the 5th filtrator steam discharge water valve 30 successively;
The endpiece that the integrality air imports valve 2 is connected with water tower 32 by water tower pressurizing valve 31, the endpiece of this water tower 32 is connected with total feed water valve 33, the endpiece of total feed water valve 33 is connected to the entrance point of the first filtrator draining valve 15 and the entrance point of the second filtrator draining valve 25 by first feed water valve 34 and second feed water valve 35 respectively, and water tower 32 also is connected with water tower vent valve 36.
In this detection system, the integrality air imports two pressure regulator valves 37 of also connecting between valve 2 and the water tower pressurizing valve 31; The entrance point of dry air supply valve 12 and nitrogen supply valve 13 connect respectively a pressure regulator valve 37 and a manual ball valve 38, their endpiece is respectively equipped with a flow control valve 39, and the entrance point of the pressure regulator valve 37 that is connected with dry air supply valve 12 is connected between two pressure regulator valves 37 that are connected with water tower pressurizing valve 31; The entrance point of first to the 5th filtrator steam discharge water valve 16,23,26,28,30 is respectively equipped with a flow control valve 39, and the import and export end of first to the 5th filtrator steam discharge water valve 16,23,26,28,30 a difference flow control valve 39 in parallel; The entrance point of first filtrator 7 advances steam valve 40 with a filtrator respectively and is connected with a pressure unit 41; The endpiece of the 3rd air release 10 also is connected with a condenser air release (not shown); The endpiece of the 4th steam bleeding water valve 27 is connected with a temperature detecting resistance 42; The import and export end of freeze drying box air release 11 an aeration valve 43 in parallel and the aeration operation valve 44 of connecting with this aeration valve 43; Be provided with a flow control valve 39 between the endpiece of water tower 32 and the total feed water valve 33; Drainpipe 17 is provided with a draining valve 45.
As shown in Figure 2, of the present invention a kind of based on the above-mentioned detection method that is used for the filter integrity detection system of freeze dryer, may further comprise the steps:
Reveal and check step 201, PLC controls second air release 8 and opens, whether integrity detection instrument 1 check test pressure is stable, if, then the dry valve 3 of PLC controlled filter device and first air release 6 are opened, otherwise, reveal and check the step interruption, PLC reports to the police, and repeats to reveal behind abnormal restoring to check step;
The moistening step 202 of first filtrator, PLC control freeze drying box air release 11, second, third air release 8,10, first feed water valve 34, first, second steam bleeding water valve 14,22, water tower pressurizing valve 31 and total feed water valve 33 are opened, when the liquid measure in the water tower 32 reaches the default liquid level intermediate value of PLC, first filtrator, 7 moistening finishing, behind first filtrator, 7 moistening finishing, PLC controls first surplus valve 20, the first filtrator steam discharge water valve 16 and the first filtrator draining valve 15 and opens;
First filtrator detects preparation process 203, and PLC control freeze drying box air release 11, second, third air release 8,10, first isolation valve 18, first surplus valve 20 and water tower air release 36 are opened;
First filtrator detects step 204, PLC control freeze drying box air release 11, second, the 3rd air release 8,10, first isolation valve 18, the integrality air imports valve 2, dry air supply valve 12 and nitrogen supply valve 13 are opened, the integrality of 1 pair first filtrator 7 of integrity detection instrument detects, and to PLC output testing result, specifically, be that integrity detection instrument 1 detects under preset pressure, pass through the numerical value of the gas of first filtrator 7 in unit interval, when this numerical value reaches the default qualified numerical value of PLC, integrity detection instrument 1 judges that first filtrator 7 is qualified, otherwise, first filtrator 7 is defective, when first filtrator 7 is qualified, then carry out first filtrator and detect completing steps 205, otherwise, PLC reports to the police, and carries out first filtrator and detects interrupt step 206;
First filtrator detects completing steps 205, PLC control freeze drying box air release 11, second, third air release 8,10, first surplus valve 20 and the first filtrator draining valve 15 are opened, and before freeze dryer is carried out the freeze-drying operation, carry out the moistening step 208 of second filtrator, after freeze dryer executes the freeze-drying operation, carry out the first filtrator drying steps 214;
First filtrator detects interrupt step 206, and PLC control freeze drying box air release 11 and second, third air release 8,10 are opened, and carry out the moistening step 208 of second filtrator;
The moistening step 208 of second filtrator, PLC control freeze drying box air release 11, the 3rd air release 10, second feed water valve 35, second, third steam bleeding water valve 22,24, water tower pressurizing valve 31 and total feed water valve 33 are opened, when the liquid measure in the water tower 32 reaches the default liquid level lower limit of PLC, second filtrator, 9 moistening finishing, behind second filtrator, 9 moistening finishing, PLC controls second surplus valve 21, the 4th filtrator steam discharge water valve 28, the 4th steam bleeding water valve 27 and the second filtrator draining valve 25 and opens;
Second filtrator detects preparation process 209, and PLC control freeze drying box air release 11, the 3rd air release 10, second isolation valve 19, second surplus valve 21 and water tower air release 36 are opened;
Second filtrator detects step 210, PLC control freeze drying box air release 11, the 3rd air release 10, second isolation valve 19, the integrality air imports valve 2, dry air supply valve 12 and nitrogen supply valve 13 are opened, the integrality of 1 pair second filtrator 9 of integrity detection instrument detects, and to PLC output testing result, specifically, be that integrity detection instrument 1 detects under preset pressure, pass through the numerical value of the gas of second filtrator 9 in unit interval, when this numerical value reaches the default qualified numerical value of PLC, integrity detection instrument 1 judges that second filtrator 9 is qualified, otherwise, second filtrator 9 is defective, when second filtrator 9 is qualified, then carry out second filtrator and detect completing steps 212, otherwise, PLC reports to the police, and carries out second filtrator and detects interrupt step 211;
Second filtrator detects interrupt step 211, PLC control freeze drying box air release 11 and the 3rd air release 10 are opened, and return earlier and carry out one time second filtrator and detect preparation process 209 (with the reliability of the testing result of guaranteeing second filtrator 9), when carrying out second filtrator detection interrupt step 211 once more, then then carry out first, second filtrator drying steps 213;
Second filtrator detects completing steps 212, and PLC control freeze drying box air release 11, the 3rd air release 10, second surplus valve 21 and the second filtrator draining valve 25 are opened, and carry out first, second filtrator drying steps 213;
First, second filtrator drying steps 213, PLC controls second air release 8 and electric heater 4 is opened, after first, second filtrator 7,9 equal dryings finish, the dry valve 3 of PLC controlled filter device, first air release 6, first, second surplus valve 20,21, first to fourth filtrator steam discharge water valve 16,23,26,28, first to fourth steam bleeding water valve 14,22,24,27 and first, second filtrator draining valve 15,25 are opened, so far, filter integrity detects and finishes;
The first filtrator drying steps 214, PLC control electric heater 4 is opened, after first filtrator, 7 dryings finish, the dry valve 3 of PLC controlled filter device, first air release 6, first surplus valve 20, first, second filtrator steam discharge water valve 16,23, first, second steam bleeding water valve 14,22 and the first filtrator draining valve 15 are opened, so far, filter integrity detects and finishes.
In carrying out the whole process of detection method of the present invention, during unusual or overload, PLC reports to the police when the dry air that enters or nitrogen pressure deficiency or integrity detection instrument 1; In addition, in the process of carrying out the first filtrator drying steps 214 and first, second filtrator drying steps 213, when electric heater 4 was unusual, PLC reported to the police.
The present invention adopts the mode of first filtrator and second filtrator series connection, therefore, even in freeze-drying process, there is one to break down and also can guarantee the quality of gas in the freeze drying box; Simultaneously, control PLC by integrity detection instrument and freeze dryer sets up communication, and only need on the guidance panel of control system, configure the parameters of detection system, automatically control each valve event by PLC and can successively finish series of steps such as moistening, detection that first filtrator and second filtrator are carried out, drying, judge according to the integrity detection instrument whether first, second filtrator is qualified.
Before freeze dryer is carried out the freeze-drying operation, must guarantee that first filtrator and second filtrator are all qualified, as long as promptly have one defective, just need to change underproof filter core, restart to detect, till two filtrators are all qualified; After finishing the freeze-drying operation, only need qualified the getting final product of filtrator, promptly in case first filtrator detects the qualified detection that just can stop.
After the filtrator integrity detection finishes, can reset by PLC, restart whole testing process, thereby realize real-time monitoring the filter integrity in the freeze dryer entire work process, guaranteed the safe reliability of freeze dryer work.
Below embodiment has been described in detail the present invention in conjunction with the accompanying drawings, and those skilled in the art can make the many variations example to the present invention according to the above description.Thereby some details among the embodiment should not constitute limitation of the invention, and the scope that the present invention will define with appended claims is as protection scope of the present invention.
Claims (9)
1. filter integrity detection system that is used for freeze dryer, described freeze dryer comprises a freeze drying box, it is characterized in that, described detection system comprises an integrity detection instrument, integrality air importing valve, the dry valve of a filtrator, an electric heater, a prefilter, first air release, first filtrator, second air release, second filtrator, the 3rd air release and a freeze drying box air release that is connected serially to described freeze drying box by pipeline successively
Described integrity detection instrument is connected with a remote PLC;
The entrance point of described prefilter is connected with a nitrogen supply valve with a dry air supply valve respectively;
The endpiece of described first air release is connected to a drainpipe by the first steam bleeding water valve, the first filtrator draining valve and the first filtrator steam discharge water valve successively;
Described first filtrator is connected with described integrity detection instrument with second isolation valve by first isolation valve respectively with second filtrator, and connect between the entrance point of described first isolation valve and second isolation valve first surplus valve and second surplus valve;
The entrance point of described second air release is connected to described drainpipe by the second steam bleeding water valve and the second filtrator steam discharge water valve successively, the entrance point of the described second filtrator steam discharge water valve is connected between described first surplus valve and second surplus valve, and the endpiece of described second air release is connected to described drainpipe by the 3rd steam bleeding water valve, the second filtrator draining valve and the 3rd filtrator steam discharge water valve successively;
The entrance point of described the 3rd air release is connected to described drainpipe by the 4th steam bleeding water valve and the 4th filtrator steam discharge water valve successively, and its endpiece is connected to described drainpipe by the 5th steam bleeding water valve and the 5th filtrator steam discharge water valve successively;
The endpiece that described integrality air imports valve is connected with a water tower by a water tower pressurizing valve, the endpiece of this water tower is connected with a total feed water valve, the endpiece of this total feed water valve is connected to the entrance point of the described first filtrator draining valve and the entrance point of the second filtrator draining valve by first feed water valve and second feed water valve respectively, and described water tower also is connected with a water tower vent valve.
2. the filter integrity detection system that is used for freeze dryer according to claim 1 is characterized in that,
Described integrality air imports two pressure regulator valves of connecting between valve and the water tower pressurizing valve;
The entrance point of described dry air supply valve and nitrogen supply valve connect respectively a pressure regulator valve and a manual ball valve, their endpiece is respectively equipped with a flow control valve, and between two pressure regulator valves that the entrance point of the pressure regulator valve that is connected with described dry air supply valve is connected to described water tower pressurizing valve is connected;
The entrance point of described first to the 5th filtrator steam discharge water valve is respectively equipped with a flow control valve, and the import and export end of described first to the 5th a filtrator steam discharge water valve difference flow control valve in parallel;
The entrance point of described first filtrator advances steam valve with a filtrator respectively and is connected with a pressure unit;
The endpiece of described the 3rd air release also is connected with a condenser air release;
The endpiece of described the 4th steam bleeding water valve is connected with a temperature detecting resistance;
The import and export end of a described freeze drying box air release aeration valve in parallel and the aeration operation valve of connecting with this aeration valve;
Be provided with a flow control valve between the endpiece of described water tower and the total feed water valve.
3. the filter integrity detection system that is used for freeze dryer according to claim 1 and 2 is characterized in that described drainpipe is provided with a draining valve.
4. the detection method based on the described detection system of claim 1 is characterized in that, described detection method may further comprise the steps:
Reveal and check step, described PLC controls second air release and opens, whether described integrity detection instrument check test pressure is stable, if, the dry valve of then described PLC controlled filter device and first air release are opened, otherwise, reveal and check the step interruption, described PLC reports to the police, and repeats to reveal behind abnormal restoring to check step;
The moistening step of first filtrator, described PLC control freeze drying box air release, second, third air release, first feed water valve, first, second steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened, behind moistening the finishing of described first filtrator, described PLC controls first surplus valve, the first filtrator steam discharge water valve and the first filtrator draining valve and opens;
First filtrator detects preparation process, and described PLC control freeze drying box air release, second, third air release, first isolation valve, first surplus valve and water tower air release are opened;
First filtrator detects step, described PLC control freeze drying box air release, second, third air release, first isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, described integrity detection instrument detects the integrality of first filtrator, and to PLC output testing result, when this testing result is first filtrator when qualified, then carry out first filtrator and detect completing steps, otherwise, described PLC reports to the police, and carries out first filtrator and detect interrupt step;
First filtrator detects completing steps, and described PLC control freeze drying box air release, second, third air release, first surplus valve and the first filtrator draining valve are opened, and carry out the moistening step of second filtrator or the first filtrator drying steps;
First filtrator detects interrupt step, and described PLC control freeze drying box air release and second, third air release are opened, and carry out the moistening step of second filtrator;
The moistening step of second filtrator, described PLC control freeze drying box air release, the 3rd air release, second feed water valve, second, third steam bleeding water valve, water tower pressurizing valve and total feed water valve are opened, behind moistening the finishing of described second filtrator, described PLC controls second surplus valve, the 4th filtrator steam discharge water valve, the 4th steam bleeding water valve and the second filtrator draining valve and opens;
Second filtrator detects preparation process, and described PLC control freeze drying box air release, the 3rd air release, second isolation valve, second surplus valve and water tower air release are opened;
Second filtrator detects step, described PLC control freeze drying box air release, the 3rd air release, second isolation valve, integrality air import valve, dry air supply valve and nitrogen supply valve and open, described integrity detection instrument detects the integrality of second filtrator, and to PLC output testing result, when this testing result is second filtrator when qualified, then carry out second filtrator and detect completing steps, otherwise, described PLC reports to the police, and carries out second filtrator and detect interrupt step;
Second filtrator detects interrupt step, described PLC control freeze drying box air release and the 3rd air release are opened, and return once described second filtrator of execution earlier and detect preparation process, when carrying out described second filtrator once more and detect interrupt step, then then carry out first, second filtrator drying steps;
Second filtrator detects completing steps, and described PLC control freeze drying box air release, the 3rd air release, second surplus valve and the second filtrator draining valve are opened, and carry out first, second filtrator drying steps;
First, second filtrator drying steps, described PLC controls second air release and electric heater is opened, after the equal drying of described first, second filtrator finishes, the dry valve of described PLC controlled filter device, first air release, first, second surplus valve, first to fourth filtrator steam discharge water valve, first to fourth steam bleeding water valve and first, second filtrator draining valve are opened, so far, filter integrity detects and finishes;
The first filtrator drying steps, described PLC control electric heater is opened, after the described first filtrator drying finishes, the dry valve of described PLC controlled filter device, first air release, first surplus valve, first, second filtrator steam discharge water valve, first, second steam bleeding water valve and the first filtrator draining valve are opened, so far, filter integrity detects and finishes.
5. the detection method of detection system according to claim 4 is characterized in that,
In the moistening step of described first filtrator, when the liquid measure in the described water tower reaches the default liquid level intermediate value of described PLC, moistening the finishing of described first filtrator;
In the moistening step of described second filtrator, when the liquid measure in the described water tower reaches the default liquid level lower limit of described PLC, moistening the finishing of described second filtrator.
6. the detection method of detection system according to claim 4 is characterized in that,
Detect in the step at described first filtrator, described integrity detection instrument detects under preset pressure, the numerical value of the gas by described first filtrator in the unit interval, when this numerical value reaches the default qualified numerical value of described PLC, described integrity detection instrument judges that first filtrator is qualified, otherwise first filtrator is defective;
Detect in the step at described second filtrator, described integrity detection instrument detects under preset pressure, the numerical value of the gas by described second filtrator in the unit interval, when this numerical value reaches the default qualified numerical value of described PLC, described integrity detection instrument judges that second filtrator is qualified, otherwise second filtrator is defective.
7. the detection method of detection system according to claim 4, it is characterized in that, detect in the completing steps at described first filtrator, before described freeze dryer is carried out the freeze-drying operation, then carry out the moistening step of described second filtrator, after described freeze dryer executes the freeze-drying operation, then carry out the described first filtrator drying steps.
8. the detection method of detection system according to claim 4, it is characterized in that described detection method also is included in reveals the preliminary step of checking between the step, confirms the liquid measure in the described water tower, when liquid measure did not reach the default liquid level higher limit of described PLC, described PLC reported to the police.
9. the detection method of detection system according to claim 8 is characterized in that, carries out in the process of described detection method, and is not enough or described integrity detection instrument is unusual or during overload, described PLC reports to the police when the dry air that enters or nitrogen pressure; Carry out in the process of the described first filtrator drying steps and first, second filtrator drying steps, when described electric heater was unusual, described PLC reported to the police.
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| CN2010105679275A CN102109364B (en) | 2010-12-01 | 2010-12-01 | Filter integrity detecting system for freeze dryer and detecting method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102435224A (en) * | 2011-11-08 | 2012-05-02 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN104048839A (en) * | 2014-05-26 | 2014-09-17 | 上海东富龙拓溥科技有限公司 | On-line integrity detecting device and method used after fully-automatic sterilization |
| CN104092592A (en) * | 2014-07-25 | 2014-10-08 | 上海共和真空技术有限公司 | Network communication system used for freeze dryer |
| US10617603B2 (en) | 2016-01-22 | 2020-04-14 | Baxter International Inc. | Sterile solutions product bag |
| WO2020147811A1 (en) * | 2019-01-18 | 2020-07-23 | 楚天科技股份有限公司 | Integrity detection system and method for freeze dryer filter |
| US11021275B2 (en) | 2016-01-22 | 2021-06-01 | Baxter International Inc. | Method and machine for producing sterile solution product bags |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3520356A1 (en) * | 1985-06-07 | 1986-12-11 | Palas GmbH Partikel- und Lasermeßtechnik, 7514 Eggenstein-Leopoldshafen | Method and device for testing filters |
| DE3626163A1 (en) * | 1986-08-01 | 1988-02-04 | Pall Gmbh | METHOD AND DEVICE FOR TESTING FILTERS IN EXPLOSION HAZARDOUS ENVIRONMENT |
| US5022265A (en) * | 1987-03-31 | 1991-06-11 | Finn-Aqua | Method and apparatus for leak testing fluid conducting freeze-drying apparatus |
| CN1351513A (en) * | 1999-04-04 | 2002-05-29 | 苏打俱乐部(Co2)股份公司 | Water dispensing apparatus with filter integrity testing system |
| CN1888281A (en) * | 2005-06-29 | 2007-01-03 | 乐金电子(天津)电器有限公司 | Method for detecting and controlling condensing dryer filter |
| CN201892546U (en) * | 2010-12-01 | 2011-07-06 | 上海共和真空技术有限公司 | Integrity detecting system for filter of freezedryer |
-
2010
- 2010-12-01 CN CN2010105679275A patent/CN102109364B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3520356A1 (en) * | 1985-06-07 | 1986-12-11 | Palas GmbH Partikel- und Lasermeßtechnik, 7514 Eggenstein-Leopoldshafen | Method and device for testing filters |
| DE3626163A1 (en) * | 1986-08-01 | 1988-02-04 | Pall Gmbh | METHOD AND DEVICE FOR TESTING FILTERS IN EXPLOSION HAZARDOUS ENVIRONMENT |
| US5022265A (en) * | 1987-03-31 | 1991-06-11 | Finn-Aqua | Method and apparatus for leak testing fluid conducting freeze-drying apparatus |
| CN1351513A (en) * | 1999-04-04 | 2002-05-29 | 苏打俱乐部(Co2)股份公司 | Water dispensing apparatus with filter integrity testing system |
| CN1888281A (en) * | 2005-06-29 | 2007-01-03 | 乐金电子(天津)电器有限公司 | Method for detecting and controlling condensing dryer filter |
| CN201892546U (en) * | 2010-12-01 | 2011-07-06 | 上海共和真空技术有限公司 | Integrity detecting system for filter of freezedryer |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102435224A (en) * | 2011-11-08 | 2012-05-02 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN102435224B (en) * | 2011-11-08 | 2013-08-07 | 上海东富龙科技股份有限公司 | On-line integrity test method of filter |
| CN104048839A (en) * | 2014-05-26 | 2014-09-17 | 上海东富龙拓溥科技有限公司 | On-line integrity detecting device and method used after fully-automatic sterilization |
| CN104092592A (en) * | 2014-07-25 | 2014-10-08 | 上海共和真空技术有限公司 | Network communication system used for freeze dryer |
| US10617603B2 (en) | 2016-01-22 | 2020-04-14 | Baxter International Inc. | Sterile solutions product bag |
| US11021275B2 (en) | 2016-01-22 | 2021-06-01 | Baxter International Inc. | Method and machine for producing sterile solution product bags |
| US11564867B2 (en) | 2016-01-22 | 2023-01-31 | Baxter International Inc. | Sterile solutions product bag |
| US11623773B2 (en) | 2016-01-22 | 2023-04-11 | Baxter International Inc. | Method and machine for producing sterile solution product bags |
| WO2020147811A1 (en) * | 2019-01-18 | 2020-07-23 | 楚天科技股份有限公司 | Integrity detection system and method for freeze dryer filter |
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|---|---|
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