WO2020138528A1 - Outil d'échantillonnage de tissu de l'utérus - Google Patents

Outil d'échantillonnage de tissu de l'utérus Download PDF

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Publication number
WO2020138528A1
WO2020138528A1 PCT/KR2018/016685 KR2018016685W WO2020138528A1 WO 2020138528 A1 WO2020138528 A1 WO 2020138528A1 KR 2018016685 W KR2018016685 W KR 2018016685W WO 2020138528 A1 WO2020138528 A1 WO 2020138528A1
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WO
WIPO (PCT)
Prior art keywords
brush
rod
collecting
operation rod
uterine
Prior art date
Application number
PCT/KR2018/016685
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English (en)
Korean (ko)
Inventor
정민호
김지현
Original Assignee
주식회사 엔도비전
정민호
김지현
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Application filed by 주식회사 엔도비전, 정민호, 김지현 filed Critical 주식회사 엔도비전
Publication of WO2020138528A1 publication Critical patent/WO2020138528A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0074—Vaginal or cervical secretions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes

Definitions

  • the present invention relates to a tissue harvesting tool used for intrauterine tissue examination, and more particularly, to a uterine tissue harvesting tool capable of effectively collecting tissue cells without involving patient suffering.
  • cervical cancer is a cancer that occurs in the cervix, which is the entrance to the uterus. It begins with epithelial dysplasia and develops into invasive cervical cancer through cervical epithelial cancer if not treated in time.
  • endometrial cancer is a disease in which abnormal cancer cells grow because endometrial cells that cover the inner space of the uterus cause genetic variation.
  • a sample for microscopic examination is required, and a brush is often used as a means for securing the sample.
  • a brush is often used as a means for securing the sample.
  • a sample is collected by rubbing the test site of the uterus with a soft brush.
  • the brush is composed of an elongated handle portion to be inserted into the womb and a sample collection portion located at the end of the handle portion.
  • the handle part is a rod-shaped member made of flexible synthetic resin, and the sample collection part is made of a support wire made by twisting a wire, and a thin brush that is fixed by being inserted into the support wire.
  • the above-mentioned conventional brush has a drawback that the sample collection part simply extends in a straight line, and thus the contact area of the sample collection part with respect to the inspection part is narrow, so that sampling is not smooth.
  • the end portion of the sample collection portion is erected with respect to the surface of the entrance portion of the cervix, and therefore, the entrance portion must be used several times. Needless to say, the carelessness of the harvester can leave a scar on surrounding tissue including the cervix.
  • the handle In order to access the sample collection section to the endometrium, the handle must be tilted or turned back and forth, which extends the time of sample collection, and the patient feels pain as the patient.
  • a curette is used for tissue collection, but there is a burden of local anesthesia because the curette involves pain when used.
  • the present invention it is possible to quickly collect samples, as well as to quickly collect samples for the entrance part of the uterus and the passage part inside the cervix at the same time, so it is convenient to use, and the sampling of the endometrial part can be efficiently performed. It is an object of the present invention to provide a useful uterine tissue collection tool when a large amount of a sample is required because the sample may be taken out by a suction method.
  • the uterine tissue collection tool of the present invention as a solution for solving the problem for achieving the above object is to be inserted into the cervix, to collect the cellular tissue of the entrance and cervix of the cervix and extend in the longitudinal direction.
  • An operation rod having a handle at the rear end; It is fixed to the distal end of the operation rod and provides a rod-shaped core portion that provides support, and is installed between a portion of the core portion and a roll brush portion contacting the cervical canal portion, between the roll brush portion and the end of the operation rod, and the roll brush portion is cervical
  • a collection brush having an inclined brush portion which is in contact with the inlet portion at the same time when it comes into contact with the tube portion is included.
  • a protective cap for moving the handle to expose the collecting brush may be further provided for use of the collecting brush.
  • the operation rod a locking projection is formed to prevent the separation of the protective cap
  • the protective cap is in the form of a cylinder with one end open, and the other end is provided with a locking jaw supported by the locking projection Can be.
  • the operation rod is provided with a notch-shaped cutting portion that is cut by focusing stress when the user applies a bending force, and a marking portion that guides the position of the cutting portion can be formed on the side of the cutting portion.
  • another uterine tissue harvesting tool of the present invention as a solution to the problem for achieving the above object is to reach the inside of the uterine body constituting the uterus to collect the cell tissue of the endometrium, extending in the longitudinal direction
  • An operation rod having a handle at its rear end;
  • a harvesting brush fixed to the distal end of the operation rod and provided with a rod-shaped deep portion providing support force and a roll brush portion fixed to the deep portion to obtain cell tissue of the endometrium; It includes an outer tube covering a part of the collecting brush and the operation rod.
  • the end of the operation rod is further provided with a shape memory deformation portion that is deformed after the collection brush is inserted into the uterine body portion to bring the collection brush closer to the uterine wall.
  • an insertion protrusion is formed on the inner circumferential surface of the outer tube, and the operation rod accommodates the insertion protrusion of the retracted outer tube to prevent the movement of the outer tube and guide the position of the holding groove.
  • the marking portion is formed.
  • Another uterine tissue collecting tool of the present invention as a solution of the problem for achieving the above object is, a hollow rod extending in the longitudinal direction and having at least one side hole open to the side; A sealing cap fixed to the front end portion of the hollow rod; A collection brush supported by the sealing cap and acquiring cell tissue of a region of interest inside the uterus; A piston positioned inside the hollow rod and positioned between the sealing cap and the side hole; It is coupled to the piston and extends to the rear of the hollow rod and is provided with a tension rod having a handle at the extended end.
  • the piston is made of rubber or synthetic resin having elasticity, and its outer circumferential surface is in close contact with the inner circumferential surface of the hollow rod to form a negative pressure inside the tensile rod when it moves to the rear of the hollow rod by the tension rod.
  • the piston is formed with a collection housing groove for accommodating the suction sucked into the hollow rod through the side hole by the negative pressure formed when the piston is retracted.
  • the collecting brush It is composed of a rod-shaped core portion providing a supporting force and a brush portion fixed to the core portion, and the sealing cap is provided with a collecting brush holder for detachably fixing the core portion.
  • the uterine tissue collection tool of the present invention made as described above has a large contact area with respect to the surface to be sampled, enabling efficient and rapid sample collection, as well as samples for the entrance of the uterus and the passageway inside the cervix. As it can be quickly collected, it is convenient to use.
  • the sample may be taken out by a suction method by applying a negative pressure that is lower than atmospheric pressure, if necessary.
  • FIG. 1 is a partial cross-sectional view for explaining the configuration of a uterine tissue collection tool according to a first embodiment of the present invention.
  • FIG. 2 is a view showing a method of using the collecting tool shown in FIG. 1.
  • FIG 3 is a partial cross-sectional view showing another example of a utensil tissue collecting tool according to the first embodiment of the present invention.
  • FIG. 4 and 5 are views for explaining a method of using the utensil tissue collection tool shown in FIG.
  • FIG. 6 is a side view showing another example of a utensil tissue collecting tool according to the first embodiment of the present invention.
  • FIG. 7 is a view for explaining an example of using the utensil tissue collecting tool shown in FIG. 6.
  • FIG. 8 is a perspective view showing a collection brush that can be applied to the uterine tissue collection tool according to the first and second embodiments of the present invention.
  • FIG. 9 is a cross-sectional view showing the configuration of a uterine tissue collecting tool according to a second embodiment of the present invention.
  • 10A and 10B are cross-sectional views showing a part of the hollow rod applicable to the uterine tissue harvesting tool shown in FIG. 9.
  • FIG. 1 is a partial cross-sectional view for explaining the configuration of the uterine tissue collection tool 20 according to the first embodiment of the present invention
  • FIG. 2 is a view showing a method of using the collection tool shown in FIG. 1.
  • Uterine tissue collection tool 20 has a feature capable of simultaneously collecting tissue cells of the cervical duct 12a and the inlet 12b of the uterus 10.
  • the basic configuration of such a collecting tool 20 is an operation rod extending in the longitudinal direction and having a handle at its rear end; It is fixed to the distal end of the operation rod and provides a rod-shaped core portion that provides support, and is installed between a portion of the core portion and a roll brush portion contacting the cervical canal portion, between the roll brush portion and the end of the operation rod, and the roll brush portion is cervical It is made of a collecting brush having an inclined brush portion which is in contact with the inlet portion at the same time when it comes into contact with the tube portion.
  • the operation rod 21 is made of a flexible material and consists of a rod body 21b and a handle 21a extending in the longitudinal direction.
  • the size of the rod body 21b may vary depending on the case, and the shape of the handle 21a may be variously designed in consideration of ergonomic convenience.
  • a locking protrusion 21d is formed on the outer circumferential surface of the distal end of the rod body 21b.
  • the locking protrusion 21d is a portion protruding in the radial direction, and the locking cap 23b of the protective cap 23 to be thickened is prevented from falling off.
  • a cutting portion 21c and a marking portion 21e are provided at the rear side of the engaging projection portion 21d.
  • the cutting portion 21c is a notched groove formed convexly, so that the rod body 21b can be easily cut. For example, when a user applies a bending force, the stress is concentrated and cut.
  • the reason for cutting the rod body 21b is to seal the specimen, that is, the collecting brush 25 in which the cell tissue is buried in the whole liquid.
  • the cutting portion 21c is broken and placed in a bottle containing a chemical solution for inspection.
  • the marking portion 21e is a display portion for guiding the position of the cutting portion 21c. For example, the user is informed so that the position of the cutting part 21c can be known immediately. Since the rod body 21b is thin and the cut portion 21c is not easily seen, the marking portion 21e can be applied to be used more conveniently. The shape or position of the marking portion can be variously changed.
  • the collection brush 25, as shown in Figure 2 has a structure capable of simultaneously collecting cell tissue from the cervical canal portion 12a and the inlet portion 12b. It is composed of a rod-shaped core portion 25a, a roll brush portion 25b, and an inclined brush portion 25c.
  • the core portion 25a is a rod-like member fixed to the front end portion of the rod body 21b of the operation rod 21, and serves to support the roll brush portion 25b and the inclined brush portion 25c.
  • the core portion 25a may be formed by twisting a wire made of stainless steel or may be formed of synthetic resin.
  • the core portion of the synthetic resin is made at the same time when the rod body 21b is molded.
  • the roll brush portion 25b occupies approximately half of the longitudinal direction of the core portion 25a and extends in the radial direction of the core portion 25a. It looks like a brush for eyebrow makeup.
  • Roll brush portion (25b) is inserted into the cervical portion (12a) of the cervix (12) in the state of the cervical portion (12a) by sweeping the inner wall surface to collect the cell tissue.
  • the inclined brush portion 25c has a form inclined forward while being fixed to the core portion 25a.
  • it is inclined to have an angle between 40 and 50 degrees with respect to the core portion 25a.
  • Each hair constituting the inclined brush portion 25c is longer than the roll brush portion 25b.
  • the inclined brush portion 25c waits in a pressed state by the protective cap 23 as shown in FIG. 1 and spreads when the protective cap 23 is removed, taking the form of FIG. 2.
  • the protective cap 23 is a cylindrical member opened to the front (opposite to the direction in which the handle is located) and receives and protects the collecting brush 25 therein.
  • a locking jaw 23b is formed on the inner circumferential surface of the rear end of the protective cap 23.
  • the locking jaw 23b is a protrusion that is caught by the locking protrusion 21d, and prevents the protective cap 23 from moving forward.
  • the protective cap 23 is movable backward, that is, in the direction of the arrow a.
  • the method of using the collecting tool 20 having the above configuration is as follows.
  • the front end of the collection tool 20 in a state where the protective cap 23 is covered is reached in front of the cervix 12, and then the protective cap 23 is moved backward. As the protective cap 23 retracts, the collecting brush 25 and the inclined brush portion 25c, which have been accommodated therein, are exposed.
  • the roll brush portion 25b is inserted into the cervix portion 12a.
  • the inclined brush portion 25c comes into contact with the inlet portion 12b. If the roll brush portion 25b is in contact with the cervical canal portion 12a and the inclined brush portion 25c is in contact with the inlet portion 12b, grab the handle 21a and arrow the rod body 21b. It moves in the g direction or vice versa and up and down directions.
  • the roll brush part 25b collects the cell tissue in the cervical canal part 12a, and the inclined brush part 25c acquires the cell tissue of the inlet part 12b.
  • the roll brush part 25b is pulled out of the cervical canal 12a and the protective cap 23 that has been retracted is advanced again, so that the collecting brush 25 is completely accommodated inside the protective cap 23. Afterwards, the extraction tool 20 is removed from the womb.
  • the protective cap 23 serves to prevent the collection brush 25 having cell tissue from contacting the inner wall of the vagina. If the collected cells are cancer cells, the cancer may be metastasized by the harvested cells, so the collection brush 25 must be wrapped with a protective cap 23.
  • FIG. 3 is a partial cross-sectional view showing another example of the uterine tissue collecting tool 20 according to the first embodiment of the present invention
  • FIGS. 4 and 5 illustrate a method of using the uterine tissue collecting tool illustrated in FIG. 3 It is a drawing for.
  • the harvesting tool 20 is inserted into the uterine body portion 16 to collect the cellular tissue of the endometrium 14.
  • the collecting tool 20 having such a purpose is composed of an operation rod 21, a collecting brush 25, and an outer tube 27.
  • the operation rod 21 is composed of a rod body 21b, which is a synthetic resin member extending in the longitudinal direction, and a handle 21a at the rear end of the rod body 21b.
  • the rod body 21b has a flexible property and has a holding groove 21f and a marking portion 21e on its outer circumferential surface.
  • the holding groove 21f extends in the circumferential direction of the rod body 21b to receive and support the insertion projections 27a formed on the outer tube 27 as constricted portions where both ends meet, thereby restraining the movement of the outer tube 27 do.
  • the marking portion 21e is a display portion for guiding the position of the holding groove 21f.
  • the shape of the holding groove 21f may be variously changed in consideration of convenience of use or productivity of the product.
  • a number of holding grooves may be applied, but the holding arc may be arranged at regular intervals, or the shape of the holding groove itself may be applied, such as a sheath.
  • the holding groove itself can be omitted.
  • a collecting brush 25 is mounted on the leading end of the rod body 21b.
  • the collecting brush 25 is composed of a rod-shaped core portion 25a and a roll brush portion 25b. As shown in Fig. 5, the collecting brush 25 serves to collect tissue cells of the endometrium 14 by moving from side to side while inserted into the uterine body 16.
  • the outer tube 27 is a hollow pipe-shaped member for accommodating a part of the rod body 21b of the collecting brush 25 and the operation rod therein.
  • An insertion protrusion 27a is formed on the inner circumferential surface of the rear end of the outer tube 27.
  • the insertion protrusion 27a is fitted into the holding groove 21f in a state where the outer tube 27 is retracted toward the handle 21a.
  • the outer tube 27 has a flexible property that can be bent by external force.
  • the collecting brush 25 covered by the outer tube 27 is placed in the uterine body portion 16 through the cervical tube portion 12a. Reach. Subsequently, the outer tube 27 is retracted in the direction of the arrow b so that the insertion protrusion 27a is fitted into the holding groove 21f. When the outer tube 27 is retracted, as shown in FIG. 5, the collecting brush 25 is exposed to the outside. In this state, the handle 21a is moved from side to side, so that the roll brush portion 25b collects the cell tissue of the endometrium 14.
  • the outer tube 27 is advanced again to accommodate the collecting brush 25 inside the outer tube 27, and then the collecting tool 20 is removed from the uterus.
  • FIG. 6 is a side view showing another example of a uterine tissue harvesting tool according to a first embodiment of the present invention
  • FIG. 7 is a view for explaining an example of using the uterine tissue harvesting tool shown in FIG. 6.
  • the shape memory deformation portion 29 is applied between the collecting brush 25 and the rod body 21b.
  • the shape memory deformation portion 29 is a rod-shaped member made of a shape memory alloy, and connects the core portion 25a and the rod body 21b.
  • the shape memory deformation part 29 maintains a straight line at normal temperature and has a property of bending in an atmosphere of body temperature. For example, it is bent sideways in the range of 34°C to 40°C.
  • the collecting brush 25 and the shape memory deformed portion 29 are wrapped, and the collecting brush 25 is placed in the uterine body portion 25, and then the outer tube 27 )
  • the collecting brush 25 is bent sideways by the action of the shape memory deformed portion 29 to automatically come into contact with the endometrium 14. It is possible for the user to collect the tissue of the endometrium 14 even if the user does not move the operation rod 21 from side to side but only rotates the shaft on the spot.
  • the outer tube 27 since the outer tube 27 has a flexible property, even if the shape memory deformation portion 29 is bent, the outer tube 27 can be moved forward to accommodate the collecting brush 25. have. That is, after the collection of the cell tissue through the collecting brush 25 is completed, the outer tube 27 is advanced to be taken out of the uterus while surrounding the collecting brush 25.
  • the collecting brush 25 After taking out the collecting cart 20 from the uterus, the collecting brush 25 is put in the liquid phase and shaken to separate the collected cell tissue and seal the liquid.
  • FIG 8 is a perspective view of another type of harvesting brush 25 that can be applied to a uterine tissue harvesting tool according to an embodiment of the present invention.
  • the collecting brush 25 shown in FIG. 8 is composed of a rod-shaped core portion 25a and a screw brush portion 25d.
  • the screw brush portion 25d has a shape in which a plurality of hairs parallel to each other are twisted at a predetermined angle while going in the longitudinal direction of the core portion 25a.
  • FIG. 9 is a cross-sectional view showing the configuration of the uterine tissue harvesting tool 40 according to the second embodiment of the present invention
  • FIGS. 10A and 10B are hollow rods 41 applicable to the uterine tissue harvesting tool shown in FIG. 9 ) Is a sectional view showing a part.
  • Uterine tissue retrieval tool 40 has a collection brush 25 as a basic configuration, and in addition, additionally has a suction function capable of aspirating a specimen.
  • the suction function for example, creates a negative pressure environment, such as a syringe, and serves to aspirate cell tissue at a site of interest.
  • the harvesting tool 40 includes a hollow rod extending in the longitudinal direction and having at least one side hole open to the side; A sealing cap fixed to the front end portion of the hollow rod; A collection brush supported by the sealing cap and acquiring cell tissue of a region of interest inside the uterus; A piston positioned inside the hollow rod and positioned between the sealing cap and the side hole; It is coupled to the piston and extends to the rear of the hollow rod and has the basic configuration of a tension rod with a handle at the extended end.
  • the hollow rod 41 is open at both ends and has at least one side hole 41b as a hollow pipe type member having a certain inner diameter.
  • the side hole 41b is a hole having a certain inner diameter or a hole having a long hole shape, and when negative pressure is formed in the straight passage 41a inside the hollow rod 41, the outer cell tissue is moved into the straight passage 41a. It is an induction passage.
  • the position of the side hole (41b) is designed to be fitted in the cervical canal (12a), with the collection brush (25) inserted into the uterine body (16).
  • a locking protrusion 41c is formed on the outer circumferential surface of the front end of the hollow rod 41.
  • the locking protrusion 41c serves to support the locking jaw 23b of the protective cap 23 to prevent the protective cap 23 from coming off.
  • the locking protrusion 41c is the same as the locking jaw 23b described with reference to FIG. 1.
  • the protective cap 23 serves to receive and protect the collecting brush 25 in a state fitted to the distal end of the hollow rod 41.
  • the front end of the hollow rod 41 is closed with a sealing cap 45.
  • the sealing cap 45 serves to seal the end portion of the hollow rod 41 and to support the collecting brush 25.
  • a collecting brush holder 45a is provided at the center of the collecting brush 25. The collecting brush holder 45a fixes the core portion 25a detachably.
  • a piston 43c is provided inside the hollow rod 41.
  • the piston 43c is a member made of synthetic resin or rubber and has an O-ring groove 43e on its outer circumferential surface.
  • the O-ring 43d is fitted in the O-ring groove 43e.
  • O-ring (43d) serves to seal between the inner circumferential surface of the hollow rod 41 and the piston (43c).
  • the piston 43c is located between the sealing cap 45 and the side hole 41b.
  • the reason why the piston 43c is positioned in front of the side hole 41b is to obtain a stronger initial suction power.
  • a negative pressure starts to be formed in the straight passage 41a, and the formed negative pressure acts as the piston 43c meets the side hole 41b to pull the sample inside. Enter After that, even if the piston 43c is further retracted, it goes without saying that the extraction of the sample continues.
  • a concave shape collecting housing 43f is formed on the surface facing the collecting brush holder 45a in the piston 43c.
  • the collection receiving groove 43f is a groove that can contain the collected cell tissue therein. After obtaining the collected object, when the collecting tool 40 is placed vertically, the sample inside the straight passage 41a flows into and collects in the collecting housing 43f.
  • the tension rod 43a is fixed to the piston 43c so that the piston 43c can be tensioned rearward.
  • the tension rod 43a is a rod-shaped member extending rearward in a state coupled to the piston 43c and has a handle 43b at its rear end. When the tension rod 43a is pulled by grabbing the handle 43b, the piston 43c moves rearward and forms a negative pressure in the straight passage 41a to suck out surrounding tissue.
  • the method of using the collecting tool 40 having the above configuration is as follows. First, while the protective cap 23 surrounds the collecting brush 25, the collecting tool 40 is inserted into the inside of the uterus. If the collecting brush 25 is located in the uterine body portion 16, the protective cap 23 is retracted toward the handle 43b. At this time, the protective cap 23 should not cover the side hole 41b.
  • the hollow rod 41 When the collecting brush 25 is exposed by retracting the protective cap 23, the hollow rod 41 is moved left and right to cause the collecting brush 25 to collect the cellular tissue of the endometrium 14. In addition, with this, the tension rod (43a) is pulled backward to suck out the cell tissue inside the cervical canal (12a). The aspirated cell tissue is collected inside the straight passage (41a).
  • the protective cap 23 is returned to the original position and the retrieval tool 40 is removed from the uterus and then a subsequent process is performed.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un outil d'échantillonnage de tissu de l'utérus qui échantillonne un tissu cellulaire provenant de l'utérus tout en étant introduit dans le col de l'utérus, l'outil d'échantillonnage de tissu de l'utérus comprenant : une tige d'actionnement qui s'étend dans une direction longitudinale et comprend un manche disposé au niveau d'une partie d'extrémité arrière de celle-ci ; et une brosse d'échantillonnage comprenant une partie centrale en forme de tige, une partie brosse à rouleaux et une partie brosse inclinée. La partie centrale est fixée à une partie d'extrémité avant de la tige d'actionnement et fournit un support. La partie brosse à rouleaux est montée sur une région de la partie centrale et entre en contact avec le canal cervical. La partie brosse inclinée est installée entre la partie brosse à rouleaux et la partie d'extrémité de la tige d'actionnement et entre en contact avec la partie d'entrée en même temps que la partie brosse à rouleaux vient en contact avec le canal cervical.
PCT/KR2018/016685 2018-12-24 2018-12-26 Outil d'échantillonnage de tissu de l'utérus WO2020138528A1 (fr)

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KR102570635B1 (ko) * 2020-11-23 2023-08-25 서울대학교병원 샘플링 장치
KR102570634B1 (ko) * 2021-07-14 2023-08-25 서울대학교병원 자궁경부세포검사 정확성 향상을 위한 사이토브러시

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