WO2020130428A3 - 홍합접착단백질 기반의 광열제 및 광열 반응형 접착성 나노입자 - Google Patents

홍합접착단백질 기반의 광열제 및 광열 반응형 접착성 나노입자 Download PDF

Info

Publication number
WO2020130428A3
WO2020130428A3 PCT/KR2019/016994 KR2019016994W WO2020130428A3 WO 2020130428 A3 WO2020130428 A3 WO 2020130428A3 KR 2019016994 W KR2019016994 W KR 2019016994W WO 2020130428 A3 WO2020130428 A3 WO 2020130428A3
Authority
WO
WIPO (PCT)
Prior art keywords
photothermal
nanoparticles
agent
adhesive
mussel
Prior art date
Application number
PCT/KR2019/016994
Other languages
English (en)
French (fr)
Other versions
WO2020130428A2 (ko
Inventor
차형준
정연수
조윤기
주계일
Original Assignee
포항공과대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 포항공과대학교 산학협력단 filed Critical 포항공과대학교 산학협력단
Priority to US17/416,685 priority Critical patent/US20220071918A1/en
Publication of WO2020130428A2 publication Critical patent/WO2020130428A2/ko
Publication of WO2020130428A3 publication Critical patent/WO2020130428A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 홍합 접착 단백질을 포함하는 광열제와 광열을 통해 생체적합성 기체를 생성하고 약물을 방출하는 광열 반응형 나노입자에 관한 것으로, 본 발명에 따른 나노입자는 근적외선을 가하였을 때 광열효과가 나타나며, 광열로 인해 생체적합성 기체를 생성하여 약물의 방출을 유도하는 삼중복합치료에 응용할 수 있다.
PCT/KR2019/016994 2018-12-21 2019-12-04 홍합접착단백질 기반의 광열제 및 광열 반응형 접착성 나노입자 WO2020130428A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/416,685 US20220071918A1 (en) 2018-12-21 2019-12-04 Mussel adhesive protein-based photothermal agent and photothermal- responsive adhesive nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180167754 2018-12-21
KR10-2018-0167754 2018-12-21

Publications (2)

Publication Number Publication Date
WO2020130428A2 WO2020130428A2 (ko) 2020-06-25
WO2020130428A3 true WO2020130428A3 (ko) 2020-08-20

Family

ID=71102853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2019/016994 WO2020130428A2 (ko) 2018-12-21 2019-12-04 홍합접착단백질 기반의 광열제 및 광열 반응형 접착성 나노입자

Country Status (3)

Country Link
US (1) US20220071918A1 (ko)
KR (1) KR102356147B1 (ko)
WO (1) WO2020130428A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643482B (zh) * 2020-07-28 2022-02-15 南京邮电大学 一种在乏氧条件下释放硫化氢的纳米粒子及其制备方法和应用
CN116099001B (zh) * 2023-04-11 2023-06-16 潍坊医学院附属医院 一种PP-Mo-NO光热抗菌剂及其制备方法和应用
CN118453950B (zh) * 2024-07-10 2024-09-13 吉林省科百医疗器材有限公司 一种医用抗菌敷料及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140027031A (ko) * 2012-08-23 2014-03-06 포항공과대학교 산학협력단 홍합 접착 단백질 기반의 생체접착 하이드로젤
KR20160026441A (ko) * 2014-09-01 2016-03-09 포항공과대학교 산학협력단 홍합접착 단백질을 포함하는 하이드로젤 제조용 조성물 및 이를 이용한 하이드로겔의 생산방법
KR20160110864A (ko) * 2015-03-13 2016-09-22 포항공과대학교 산학협력단 홍합 접착 단백질을 이용한 약물전달용 pH-반응성 나노입자 및 이의 제조방법
KR20160129982A (ko) * 2015-04-30 2016-11-10 강호창 홍합접착단백질 유래 치주질환의 예방 또는 치료용 골 바인더 및 이의 제조방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE494300T1 (de) * 2004-03-26 2011-01-15 Postech Foundation Biologischer klebstoff aus muscheln
CA2701006C (en) * 2006-09-27 2016-07-12 University Of Connecticut Implantable biosensor and methods of use thereof
WO2009001220A2 (en) * 2007-06-26 2008-12-31 Universitetet I Oslo Functionalization of microscopy probe tips
JP2012526155A (ja) * 2009-08-25 2012-10-25 ポステック アカデミー−インダストリー ファンデーション イガイ接着蛋白質またはその変異体に陰イオン性高分子が含まれたコアセルベート
US9005992B2 (en) * 2011-03-18 2015-04-14 Postech Academy-Industry Foundation Immobilizing fusion protein for effective and oriented immobilization of antibody on surfaces
BR102012016127B1 (pt) * 2012-06-27 2020-09-24 Universidade Estadual De Campinas-Unicamp Nanopartículas ferromagnéticas funcionalizadas, processo de funcionalização das nanopartículas ferromagnéticas, usos das mesmas e composição farmacêutica
KR101435606B1 (ko) * 2012-06-28 2014-08-29 포항공과대학교 산학협력단 홍합 접착 단백질에의 생체 내 잔기-특이적 ｄｏｐａ 도입 방법
US9801972B2 (en) * 2014-10-02 2017-10-31 Postech Academy-Industry Foundation Mussel-inspired bioactive surface coating composition generating silica nanoparticles
KR101807593B1 (ko) * 2015-12-30 2017-12-11 포항공과대학교 산학협력단 흉터 최소화 상처 재생 촉진용 재조합 폴리펩타이드 및 이를 포함하는 생체 접착 소재
US11267851B2 (en) * 2017-07-18 2022-03-08 Posco Antimicrobial adhesive protein, antimicrobial nanoparticle, antimicrobial composition comprising same nanoparticle, and preparation method for same composition
KR102010051B1 (ko) * 2017-09-20 2019-08-12 주식회사 포스코 카테콜 치환된 음이온성 고분자로부터 형성된 코아세르베이트, 이를 포함하는 접착제 및 이의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140027031A (ko) * 2012-08-23 2014-03-06 포항공과대학교 산학협력단 홍합 접착 단백질 기반의 생체접착 하이드로젤
KR20160026441A (ko) * 2014-09-01 2016-03-09 포항공과대학교 산학협력단 홍합접착 단백질을 포함하는 하이드로젤 제조용 조성물 및 이를 이용한 하이드로겔의 생산방법
KR20160110864A (ko) * 2015-03-13 2016-09-22 포항공과대학교 산학협력단 홍합 접착 단백질을 이용한 약물전달용 pH-반응성 나노입자 및 이의 제조방법
KR20160129982A (ko) * 2015-04-30 2016-11-10 강호창 홍합접착단백질 유래 치주질환의 예방 또는 치료용 골 바인더 및 이의 제조방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JEONG, Y.: "Sprayable adhesive nanotherapeutics : mussel protein-based n anoparticles for highly efficient locoregional cancer therapy", ACS NANO, vol. 12, no. 9, 27 July 2018 (2018-07-27), pages 8909 - 8919, XP055732140 *
KAO, P. T.: "Controllable no release from cul.6s nanoparticle decomposit ion of s-nitrosoglutathiones following photothermal disintegration of polyme rsomes to elicit cerebral vasodilatory activity", CHEM. SCI., vol. 8, no. 1, 11 August 2016 (2016-08-11), pages 291 - 297, XP055732139 *

Also Published As

Publication number Publication date
KR20200078336A (ko) 2020-07-01
WO2020130428A2 (ko) 2020-06-25
KR102356147B1 (ko) 2022-01-27
US20220071918A1 (en) 2022-03-10

Similar Documents

Publication Publication Date Title
WO2020130428A3 (ko) 홍합접착단백질 기반의 광열제 및 광열 반응형 접착성 나노입자
MX2020003482A (es) Material de recubrimiento funcional de enfriamiento radiativo y aplicacion del mismo.
WO2015138870A3 (en) Compositions and methods for targeted epigenetic modification
TWD184997S (zh) 化妝品罐
MX2016014465A (es) Composiciones de bioceramica y usos biomoduladores de las mismas.
EP3668497A4 (en) METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER, INFLAMMATION, OR IMMUNE-REACTION-ASSOCIATED DISEASES
EP4403229A3 (en) Expression of pten-long with oncolytic viruses
MX2015011296A (es) Dispositivo foto-terapeutico, metodo y uso.
TWD185000S (zh) 化妝品罐
TWD183922S (zh) 燈具
EP3463577A4 (en) COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH HUMAN PAPILLOMAVIRUS (HPV)
WO2015105539A3 (en) Radiation system with emanating source surrounding an internal attenuation component
TWD182971S (zh) 反向器
TWD179979S (zh) 香水瓶
TWD186162S (zh) 化妝品罐
WO2019040106A3 (en) COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES
WO2018183182A8 (en) Methods and compositions for reduction of immunogenicity
WO2015144898A9 (en) Compositions and devices for sclerotherapy using light hardening glues
EP3807348A4 (en) CELLULOSIC GELS, FILMS AND COMPOSITE MATERIALS WITH THE GELS AND METHODS FOR THEIR PRODUCTION
PH12019501737A1 (en) Heat treatable coated article having zirconium nitride and ito based ir reflecting layers
WO2019099578A8 (en) Use of imidazopyrimidine for modulating human immune response
TWD191584S (zh) 有蓋的瓶子
WO2015112850A3 (en) Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders
TWD184324S (zh) 眼鏡（十三）
TWD183236S (zh) 眼鏡（十四）

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19898948

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19898948

Country of ref document: EP

Kind code of ref document: A2