WO2020119257A1 - 一种参薯破壁饮片及其制备方法 - Google Patents

一种参薯破壁饮片及其制备方法 Download PDF

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WO2020119257A1
WO2020119257A1 PCT/CN2019/112577 CN2019112577W WO2020119257A1 WO 2020119257 A1 WO2020119257 A1 WO 2020119257A1 CN 2019112577 W CN2019112577 W CN 2019112577W WO 2020119257 A1 WO2020119257 A1 WO 2020119257A1
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ginseng
drying
temperature
broken
ultrafine
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PCT/CN2019/112577
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French (fr)
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廖年生
胡贤德
眭荣春
邹明明
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江西赣隆药业有限公司
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Publication of WO2020119257A1 publication Critical patent/WO2020119257A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

Definitions

  • the invention relates to the technical field of Chinese medicine broken wall decoction pieces, in particular to a ginseng potato broken wall decoction piece and a preparation method thereof.
  • Chinese medicine broken wall pieces are a kind of traditional Chinese medicine pieces that are processed into traditional Chinese medicine pieces by using modern ultrafine crushing technology.
  • the Chinese medicine broken wall pieces are all ingredients, and the medicinal substance base remains unchanged, which is in line with the connotation of Chinese medicine pieces.
  • the sexual taste and return of the menstrual, function and indications are consistent with the nature of traditional pieces. It is brewed directly and can be taken together with medicine residue.
  • the broken piece technology is not widely used in domestic pieces production enterprises, and no real industry norms have been formed.
  • Ginseng is derived from the dried tubers of Dioscorea alata (Dioscorea alata), which is mainly produced in Zhejiang, Jiangxi, Guangdong, Guangxi, Hunan, Hubei, Sichuan, Fujian and other places.
  • the tubers contain various components such as diosgenin, ginseng polysaccharides, polyphenols and so on. It has the effects of strengthening the spleen, nourishing the lungs, benefiting qi, reducing swelling, and relieving pain. It is mainly used for spleen deficiency, diarrhea, lung deficiency, cough, edema, urination, and spermatorrhea. However, there is no report about Shenshu broken wall pieces and its preparation process.
  • the purpose of the present invention is to provide a ginseng potato broken wall decoction piece and a preparation method thereof.
  • the invention provides a method for preparing ginseng potato broken wall pieces, which includes the following steps:
  • step (2) Put the ginseng potato granules obtained in step (1) under vacuum conditions and perform microwave treatment;
  • step (3) The ultrafine powder obtained in step (3) is mixed with the second ethanol aqueous solution, and then granulated and dried.
  • the concentration of the first ethanol aqueous solution is 30-60% by weight.
  • the soaking conditions include: a temperature of 50-80°C and a time of 1-3 hours.
  • the conditions for freeze drying include: a temperature of -10°C to -50°C, and a vacuum of 5-50Pa.
  • the conditions of microwave treatment include: a temperature of 10-40° C., a time of 10-60 min, a microwave power of 5-20 kW, and a vacuum of 5-50 Pa.
  • the ultrafine crushing process crushes the ginseng potato particles into ultrafine powder below 40 microns.
  • the concentration of the second aqueous ethanol solution is 60-80% by weight.
  • the mixing mass ratio of the ultrafine powder and the second aqueous ethanol solution is 1:0.3-1.
  • the drying is freeze drying.
  • the invention also provides the ginseng potato broken wall prepared by the above method.
  • the ginseng medicinal material is firstly crushed, followed by soaking, freeze-drying, freezing storage and microwave treatment in sequence, such a complete set of processing technology can be applied to the cell wall of ginseng potato After embrittlement, the ginseng potato cells can be easily broken through ultra-fine crushing, thereby obtaining ginseng broken wall pieces with a high ratio of broken walls.
  • the product composition of the ginseng broken wall decoction pieces prepared according to the method of the present invention has good consistency, stable quality and controllability, which greatly benefits the development of modern large-scale industrialization.
  • the preparation method of the ginseng potato broken wall pieces of the present invention includes the following steps:
  • step (2) Put the ginseng potato granules obtained in step (1) under vacuum conditions and perform microwave treatment;
  • step (3) The ultrafine powder obtained in step (3) is mixed with the second ethanol aqueous solution, and then granulated and dried.
  • step (1) after being pre-crushed, the size of the particles obtained after crushing the ginseng medicinal material is 10-100 mesh, specifically, for example, 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh , 60 mesh, 70 mesh, 80 mesh, 90 mesh or 100 mesh.
  • the pre-crushing process may be implemented by using a conventional crushing device in the art, which will not be repeated here.
  • the concentration of the first ethanol aqueous solution used to soak the ginseng potato particles may be 30-60% by weight, specifically, for example, 30% by weight, 35% by weight, 40% by weight, 45 % By weight, 50% by weight, 55% by weight or 60% by weight. In a preferred case, the concentration of the first aqueous ethanol solution is 40-50% by weight.
  • immersing the ginseng potato granules with the above-mentioned concentration of ethanol aqueous solution is beneficial to embrittlement of the ginseng cell wall, and thus it is advantageous to obtain a ginseng broken wall decoction piece with a high wall breaking rate.
  • the soaking conditions may include: a temperature of 50-80°C (such as 50°C, 60°C, 70°C or 80°C), and a time of 1-3 hours (such as 1 hour, 1.5 hours, 2 hours , 2.5 hours or 3 hours).
  • the ginseng potato granules are soaked at a relatively high temperature and then frozen at a very low temperature, so that the ginseng potato cells are exposed to a large temperature difference, which is beneficial to the ginseng potato cell wall Carrying out embrittlement, which is beneficial to obtain high-breaking rate of Shenshu broken pieces.
  • the volume ratio of ginseng potato particles to the aqueous ethanol solution may be 1:2-10, preferably 1:3-8, and more preferably 1:3-5.
  • the conditions for freeze-drying may include: a temperature of -10°C to -50°C (such as -10°C, -15°C, -20°C, -25°C, -30°C, -35°C,- 40°C, -45°C or -50°C), the vacuum degree is 5-50Pa (such as 5Pa, 10Pa, 20Pa, 30Pa, 40Pa or 50Pa).
  • vacuum refers to absolute pressure.
  • the filter can be filtered by a conventional filter screen in the art.
  • the filter may be a stainless steel wire mesh with a mesh size of 200 mesh.
  • the conditions of microwave treatment may include: a temperature of 10-40°C, preferably 20-30°C; a time of 10-60min, preferably 20-40min; a microwave power of 5-20kW, preferably 10-20kW; vacuum degree is 5-50Pa, preferably 10-20Pa.
  • the ultrafine crushing process crushes the ginseng potato particles into ultrafine powder of less than 40 microns (preferably 5-40 microns, more preferably 5-30 microns).
  • the equipment used for ultrafine crushing can be a wall-breaking crusher, such as CW5-100QA wall-breaking ultrafine crusher.
  • the concentration of the second aqueous ethanol solution may be 60-80% by weight, specifically, for example, 60% by weight, 65% by weight, 70% by weight, 75% by weight, or 80% by weight.
  • step (4) the mixing mass ratio of the ultrafine powder and the second aqueous ethanol solution is 1:0.3-1, preferably 1:0.5-0.7.
  • the drying method may be contact drying, airflow drying, tunnel oven drying, vacuum drying, boiling drying, freeze drying, far infrared drying or microwave drying.
  • the drying method is freeze drying.
  • the invention also provides the ginseng potato broken wall prepared by the above method.
  • step (1) The ginseng potato granules obtained in step (1) are subjected to microwave treatment under vacuum conditions, the conditions of microwave treatment are: temperature 25°C, time 30min, microwave power 15kW, vacuum degree 15Pa.
  • step (3) Ultrafinely pulverize the ginseng potato particles obtained in step (2) with a CW5-100QA wall breaking ultrafine pulverizer to obtain ultrafine powder with a particle size of 5-30 microns.
  • step (1) The ginseng potato granules obtained in step (1) are subjected to microwave treatment under vacuum conditions.
  • the conditions of microwave treatment are: temperature 20° C., time 40 min, microwave power 10 kW, vacuum degree 10 Pa.
  • step (3) Ultra-finely crush the ginseng potato particles obtained in step (2) with a CW5-100QA wall-breaking ultrafine pulverizer to obtain ultrafine powder with a particle size of 5-30 microns.
  • step (1) The ginseng potato granules obtained in step (1) are subjected to microwave treatment under vacuum conditions, the conditions of microwave treatment are: temperature 30 °C, time 20 min, microwave power 20 kW, vacuum degree 20 Pa.
  • step (3) Ultra-finely crush the ginseng potato particles obtained in step (2) with a CW5-100QA wall-breaking ultrafine pulverizer to obtain ultrafine powder with a particle size of 5-30 microns.
  • the ginseng potato broken wall pieces were prepared according to the method of Example 1, except that the process of immersing in the ethanol aqueous solution was not carried out, thereby preparing the ginseng potato broken wall pieces D1.
  • the ginseng broken wall pieces were prepared according to the method of Example 1, except that the natural air-drying method was used instead of freeze drying to prepare the ginseng broken wall pieces D2.
  • the ginseng broken wall pieces were prepared according to the method of Example 1, except that freeze-drying was not performed after freeze-drying, but microwave treatment was performed directly, thereby preparing the ginseng broken wall pieces sample D3.
  • the limit of unbroken wall cells of Shenshu broken wall pieces was tested by the following method: Take 0.1 g of Shenshu broken wall pieces, add hydrated chloral solution (the volume ratio of chloral hydrate test solution to water is 1:1) and place it in 10ml Mount the slide on a glass slide and observe under a microscope. Under a 10 ⁇ 10 field of view, the number of powders of intact cells larger than 100 microns is 0-5. The test results are shown in Table 1 below.

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Abstract

一种参薯破壁饮片及其制备方法。该方法包括以下步骤：(1)取干燥的参薯药材，预粉碎至粒度为10-100目的颗粒，接着用第一乙醇水溶液浸泡，过滤，将得到的滤饼冷冻干燥，然后在-10℃～0℃的温度下放置1-3小时；(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理；(3)将步骤(2)得到的参薯颗粒进行超微粉碎；(4)将步骤(3)得到的超微细粉与第二乙醇水溶液混合，然后进行制粒和干燥。

Description

一种参薯破壁饮片及其制备方法 技术领域
本发明涉及中药破壁饮片技术领域，具体涉及一种参薯破壁饮片及其制备方法。
背景技术
中药破壁饮片是运用现代超微粉碎技术将传统饮片加工而成的一种以粉末形式入药的中药饮片。中药破壁饮片为全成分入药，药用物质基础不变，符合中药饮片的内涵，破壁后饮片的性味与归经、功能与主治等保持与传统饮片的性质相一致，破壁饮片可以直接冲泡服用，可连同药渣一起服用。但是，破壁饮片技术目前在国内饮片生产企业应用并不广泛，也没有形成真正的行业规范。因此，研究开发出一种中药破壁饮片的制备方法，充分发挥中药破壁饮片全成分入药的优势，通过破壁保留传统中药的全部药效成分，进而更利于服用者对药效成分的吸收，以缓解现有中药颗粒加水浓缩后提取，只能提取中药材部分药效成分的问题，变得十分必要和迫切。
参薯来源于薯蓣科植物参薯(Dioscorea alata L.)的干燥块茎，主产于浙江、江西、广东、广西、湖南、湖北、四川、福建等地。其块茎中含有薯蓣皂苷元、参薯多糖、多酚等多种成分。具有健脾、补肺、益精气、消肿、止痛等功效，主要用于脾虚欠泻，肺虚喘咳、水 肿、小便不利、肾虚不固的遗精、尿频。然而，目前还没有关于参薯破壁饮片及其制备工艺的报道。
发明内容
本发明的目的是提供一种参薯破壁饮片及其制备方法。
本发明提供了一种参薯破壁饮片的制备方法，该方法包括以下步骤：
(1)取干燥的参薯药材，预粉碎至粒度为10-100目的颗粒，接着用第一乙醇水溶液浸泡，过滤，将得到的滤饼冷冻干燥，然后在-10℃～0℃的温度下放置1-3小时；
(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理；
(3)将步骤(2)得到的参薯颗粒进行超微粉碎；
(4)将步骤(3)得到的超微细粉与第二乙醇水溶液混合，然后进行制粒和干燥。
优选地，在步骤(1)中，所述第一乙醇水溶液的浓度为30-60重量％。
优选地，在步骤(1)中，浸泡的条件包括：温度为50-80℃，时间为1-3小时。
优选地，在步骤(1)中，冷冻干燥的条件包括：温度为-10℃～-50℃，真空度为5-50Pa。
优选地，在步骤(2)中，微波处理的条件包括：温度为10-40℃，时间为10-60min，微波的功率为5-20kW，真空度为5-50Pa。
优选地，在步骤(3)中，所述超微粉碎的过程将所述参薯颗粒粉碎为40微米以下的超微细粉。
优选地，在步骤(4)中，所述第二乙醇水溶液的浓度为60-80重量％。
优选地，在步骤(4)中，所述超微细粉与所述第二乙醇水溶液的混合质量比为1：0.3-1。
优选地，在步骤(4)中，所述干燥为冷冻干燥。
本发明还提供了由上述方法制备的参薯破壁饮片。
本发明的有益效果是：
按照本发明所述的参薯破壁饮片的制备方法，首先将参薯药材进行预粉碎，接着依次进行浸泡、冷冻干燥、冷冻储存和微波处理，这样一整套的处理工艺可以对参薯的细胞壁进行脆化，然后通过超微粉碎可以容易地使参薯细胞破壁，从而得到破壁比率较高的参薯破壁饮片。
而且，按照本发明所述的方法制备的参薯破壁饮片的产品成分一致性较好，质量稳定、可控，大大利于现代大产业化发展。
具体实施方式
以下对本发明的具体实施方式进行详细说明。应当理解的是，此处所描述的具体实施方式仅用于说明和解释本发明，并不用于限制本发明。
在本文中所披露的范围的端点和任何值都不限于该精确的范围 或值，这些范围或值应当理解为包含接近这些范围或值的值。对于数值范围来说，各个范围的端点值之间、各个范围的端点值和单独的点值之间，以及单独的点值之间可以彼此组合而得到一个或多个新的数值范围，这些数值范围应被视为在本文中具体公开。
本发明所述的参薯破壁饮片的制备方法包括以下步骤：
(1)取干燥的参薯药材，预粉碎至粒度为10-100目的颗粒，接着用第一乙醇水溶液浸泡，过滤，将得到的滤饼冷冻干燥，然后在-10℃～0℃的温度下放置1-3小时；
(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理；
(3)将步骤(2)得到的参薯颗粒进行超微粉碎；
(4)将步骤(3)得到的超微细粉与第二乙醇水溶液混合，然后进行制粒和干燥。
在步骤(1)中，通过预粉碎之后，所述参薯药材粉碎后得到的颗粒的尺寸为10-100目，具体地，例如可以为10目、20目、30目、40目、50目、60目、70目、80目、90目或100目。通过对所述参薯药材进行预粉碎，提高参薯药材的比表面积，从而更有利于后续的浸泡、冷冻以及微波处理等工序对参薯细胞壁的脆化。在本发明中，所述预粉碎的工序采用本领域常规的粉碎装置实施即可，在此不再赘述。
在步骤(1)中，对参薯颗粒进行浸泡所用的所述第一乙醇水溶液的浓度可以为30-60重量％，具体地，例如可以为30重量％、35重量％、40重量％、45重量％、50重量％、55重量％或60重量％。 在优选情况下，所述第一乙醇水溶液的浓度为40-50重量％。在本发明中，使用上述浓度的乙醇水溶液对参薯颗粒进行浸泡，有利于对参薯细胞壁进行脆化，从而有利于获得高破壁率的参薯破壁饮片。
在步骤(1)中，浸泡的条件可以包括：温度为50-80℃(如50℃、60℃、70℃或80℃)，时间为1-3小时(如1小时、1.5小时、2小时、2.5小时或3小时)。在本发明中，通过使参薯颗粒在相对较高的温度下进行浸泡，然后在极低的温度下进行冷冻处理，使得参薯细胞暴露在较大温差下，这样有利于对对参薯细胞壁进行脆化，从而有利于获得高破壁率的参薯破壁饮片。
在步骤(1)中，在所述浸泡的过程中，参薯颗粒与乙醇水溶液的体积比可以为1：2-10，优选为1：3-8，更优选为1：3-5。
在步骤(1)中，冷冻干燥的条件可以包括：温度为-10℃～-50℃(如-10℃、-15℃、-20℃、-25℃、-30℃、-35℃、-40℃、-45℃或-50℃)，真空度为5-50Pa(如5Pa、10Pa、20Pa、30Pa、40Pa或50Pa)。在本文中，真空度是指绝对压力。
在步骤(1)中，过滤可以采用本领域常规的滤网过滤。在具体的实施方式中，所述滤网可以是网孔尺寸为200目的不锈钢丝网。
在步骤(2)中，微波处理的条件可以包括：温度为10-40℃，优选为20-30℃；时间为10-60min，优选为20-40min；微波的功率为5-20kW，优选为10-20kW；真空度为5-50Pa，优选为10-20Pa。
在步骤(3)中，优选地，所述超微粉碎的过程将所述参薯颗粒粉碎为40微米以下(优选为5-40微米，更优选为5-30微米)的超 微细粉。超微粉碎所使用的设备可以为破壁粉碎机，如CW5-100QA破壁超微粉碎机。
在步骤(4)中，所述第二乙醇水溶液的浓度可以为60-80重量％，具体地，例如可以为60重量％、65重量％、70重量％、75重量％或80重量％。
在步骤(4)中，所述超微细粉与所述第二乙醇水溶液的混合质量比为1：0.3-1，优选为1:0.5-0.7。
在步骤(4)中，所述干燥的方法可以为接触干燥、气流干燥、隧道式烘箱干燥、真空干燥、沸腾干燥、冷冻干燥、远红外干燥或微波干燥。在优选情况下，所述干燥的方法为冷冻干燥。
本发明还提供了由上述方法制备的参薯破壁饮片。
以下将通过实施例对本发明进行详细描述。
实施例1
(1)取2.0kg参薯药材，预粉碎至粒度为50目的颗粒，接着加入参薯颗粒4倍体积的45重量％的乙醇溶液，在70℃下浸泡2小时，用200目的不锈钢丝网过滤，将得到的滤饼在-20℃下、在30Pa真空度下冷冻干燥。待参薯颗粒干燥后在-5℃下放置2小时。
(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理，微波处理的条件为：温度为25℃，时间为30min，微波的功率为15kW，真空度为15Pa。
(3)用CW5-100QA破壁超微粉碎机对步骤(2)得到的参薯颗 粒进行超微粉碎，得到粒度为5-30微米的超微细粉。
(4)将所述超微细粉与浓度为70重量％的乙醇水溶液以重量比为1：0.6进行混合，挤出制粒，然后在-20℃下、在30Pa真空度下冷冻干燥，从而制得参薯破壁饮片样品A1。
实施例2
(1)取2.0kg参薯药材，预粉碎至粒度为80目的颗粒，接着加入参薯颗粒3倍体积的60重量％的乙醇溶液，在50℃下浸泡3小时，用200目的不锈钢丝网过滤，将得到的滤饼在-30℃下、在20Pa真空度下冷冻干燥。待参薯颗粒干燥后在-8℃下放置1小时。
(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理，微波处理的条件为：温度为20℃，时间为40min，微波的功率为10kW，真空度为10Pa。
(3)用CW5-100QA破壁超微粉碎机对步骤(2)得到的参薯颗粒进行超微粉碎，得到粒度为5-30微米的超微细粉。
(4)将所述超微细粉与浓度为60重量％的乙醇水溶液以重量比为1：0.7进行混合，挤出制粒，然后在-30℃下、在20Pa真空度下冷冻干燥，从而制得参薯破壁饮片样品A2。
实施例3
(1)取2.0kg参薯药材，预粉碎至粒度为40目的颗粒，接着加入参薯颗粒5倍体积的40重量％的乙醇溶液，在80℃下浸泡1小时， 用200目的不锈钢丝网过滤，将得到的滤饼在-10℃下、在10Pa真空度下冷冻干燥。待参薯颗粒干燥后在-2℃下放置3小时。
(2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理，微波处理的条件为：温度为30℃，时间为20min，微波的功率为20kW，真空度为20Pa。
(3)用CW5-100QA破壁超微粉碎机对步骤(2)得到的参薯颗粒进行超微粉碎，得到粒度为5-30微米的超微细粉。
(4)将所述超微细粉与浓度为80重量％的乙醇水溶液以重量比为1：0.5进行混合，挤出制粒，然后在-10℃下、在10Pa真空度下冷冻干燥，从而制得参薯破壁饮片样品A3。
对比例1
按照实施例1的方法制备参薯破壁饮片，所不同的是，不实施乙醇水溶液浸泡的工序，从而制得参薯破壁饮片样品D1。
对比例2
按照实施例1的方法制备参薯破壁饮片，所不同的是，用自然风干的方式代替冷冻干燥，从而制得参薯破壁饮片样品D2。
对比例3
按照实施例1的方法制备参薯破壁饮片，所不同的是，在冷冻干燥之后不进行冷冻储存，而是直接进行微波处理，从而制得参薯破壁 饮片样品D3。
测试例
参薯破壁饮片的未破壁细胞限度采用如下方法进行测试：取参薯破壁饮片0.1g，加水合氯醛水溶液(水合氯醛试液与水的体积比为1：1)10ml置于载玻片上，装片，置于显微镜下观察，在10×10倍视野下，大于100微米且完整的细胞的粉末数目为0-5个。测试结果如下表1所示。
表1
实施例编号 未破壁细胞限度(个)
实施例1 0
实施例2 2
实施例3 1
对比例1 7
对比例2 6
对比例3 8
通过表1的结果可以看出，采用本发明所述的方法可以制得破壁比率较高的参薯破壁饮片。
以上详细描述了本发明的优选实施方式，但是，本发明并不限于此。在本发明的技术构思范围内，可以对本发明的技术方案进行多种 简单变型，包括各个技术特征以任何其它的合适方式进行组合，这些简单变型和组合同样应当视为本发明所公开的内容，均属于本发明的保护范围。

Claims (10)

  1. 一种参薯破壁饮片的制备方法，其特征在于，该方法包括以下步骤：
    (1)取干燥的参薯药材，预粉碎至粒度为10-100目的颗粒，接着用第一乙醇水溶液浸泡，过滤，将得到的滤饼冷冻干燥，然后在-10℃～0℃的温度下放置1-3小时；
    (2)将步骤(1)得到的参薯颗粒置于真空条件下进行微波处理；
    (3)将步骤(2)得到的参薯颗粒进行超微粉碎；
    (4)将步骤(3)得到的超微细粉与第二乙醇水溶液混合，然后进行制粒和干燥。
  2. 根据权利要求1所述的方法，其特征在于，在步骤(1)中，所述第一乙醇水溶液的浓度为30-60重量％。
  3. 根据权利要求1所述的方法，其特征在于，在步骤(1)中，浸泡的条件包括：温度为50-80℃，时间为1-3小时。
  4. 根据权利要求1-3中任意一项所述的方法，其特征在于，在步骤(1)中，冷冻干燥的条件包括：温度为-10℃～-50℃，真空度为5-50Pa。
  5. 根据权利要求1所述的方法，其特征在于，在步骤(2)中，微波处理的条件包括：温度为10-40℃，时间为10-60min，微波的功率为5-20kW，真空度为5-50Pa。
  6. 根据权利要求1所述的方法，其特征在于，在步骤(3)中，所述超微粉碎的过程将所述参薯颗粒粉碎为40微米以下的超微细粉。
  7. 根据权利要求1所述的方法，其特征在于，在步骤(4)中，所述第二乙醇水溶液的浓度为60-80重量％。
  8. 根据权利要求1或7所述的方法，其特征在于，在步骤(4)中，所述超微细粉与所述第二乙醇水溶液的混合质量比为1：0.3-1。
  9. 根据权利要求1所述的方法，其特征在于，在步骤(4)中，所述干燥为冷冻干燥。
  10. 由权利要求1-9中任意一项所述的方法制备的参薯破壁饮片。
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