WO2020105642A1 - 歯科用清掃材及び歯科用仮着材除去材 - Google Patents
歯科用清掃材及び歯科用仮着材除去材Info
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- WO2020105642A1 WO2020105642A1 PCT/JP2019/045299 JP2019045299W WO2020105642A1 WO 2020105642 A1 WO2020105642 A1 WO 2020105642A1 JP 2019045299 W JP2019045299 W JP 2019045299W WO 2020105642 A1 WO2020105642 A1 WO 2020105642A1
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- dental
- compound
- group
- organic amine
- temporary
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
Definitions
- the present invention provides dental restorations such as porcelain, ceramics, metal oxides, dental composite resin cured products containing inorganic fillers and resins (hereinafter simply referred to as “dental composite resin cured products”), and
- the present invention relates to a dental cleaning material used for cleaning abutment teeth such as tooth surfaces.
- the present invention also relates to a temporary dental adhesive removal material.
- dental restorations consist of porcelain, ceramics, metal oxides, hardened dental composite resins, etc., and are used to adapt to tooth defects in various ways.
- Came This dental restoration is generally subjected to a preliminary insertion prior to fixation for the purpose of confirming its suitability.
- a protein-containing body fluid for example, saliva, dental fluid, blood, etc.
- protein-containing body fluids or the like are used between the dental restoration and the dental adhesive or the dental cement during the subsequent adhesion between the dental restoration and the abutment tooth, or between the abutment tooth and the dental tooth. It causes a decrease in adhesion between the adhesive and the dental cement.
- a dental cleaning material has been proposed as a means for removing the contamination caused by the protein-containing body fluid (Patent Documents 1 and 2).
- Patent Document 1 describes a tooth surface cleaning material as a method for removing plaque and coloring on the tooth surface.
- US Pat. No. 6,096,837 describes cleaning of dental restorations, in particular compositions containing cleaning particles for removing protein contaminants.
- a temporary restoration made of room temperature polymerized resin etc. is temporarily attached with a temporary material called a temporary adhesive.
- the treatment to do is generally performed.
- the material used for the purpose is also called a temporary sealing material, but in the present specification, a temporary sealing material is also included as a kind of temporary adhesive material.
- the temporary adhesive is not required to have high adhesive strength for a long period of time like the adhesive used to bond the final restoration, but it is 1 to several times until the final restoration is mounted. It suffices that the temporary restoration has sufficient adhesive strength to fix the temporary restoration to the cavity or the abutment tooth in a relatively short period of week.
- Typical types of temporary adhesives include (1) Fletcher cement, (2) eugenol-based temporary adhesive, (3) non-eugenol-based temporary adhesive, and (4) carboxylic acid-based temporary adhesive ( See, for example, Patent Document 3.
- Fletcher cement contains zinc oxide and gum arabic as main components, and is used by kneading them with distilled water to form a mud.
- Eugenol-based temporary adhesives generally contain zinc oxide and eugenol as the main components, and there are many temporary sealing materials.
- the non-eugenol-based temporary adhesive material contains zinc oxide and an aliphatic compound or an aromatic compound as main components, and does not contain eugenol.
- the carboxylic acid-based temporary adhesive material contains zinc oxide and polyacrylic acid as main components, and is mixed with a tannin fluoride compound material called a HY material that has an effect of strengthening tooth structure (dentin).
- Non-Patent Document 1 it is desirable that the temporary adhesive material is completely removed from the cavity and the abutment tooth which are composed of the tooth material during the operation of attaching the final restoration material. It is said to be a factor that greatly affects the adhesive strength with the like (see Non-Patent Document 1, for example).
- Non-Patent Document 2 Current methods of removing temporary adhesive materials include mechanical treatment with an air scaler or rotating brush, ultrasonic cleaning treatment, etc. (see Non-Patent Document 2, for example).
- Patent Document 1 defines a dental cleaning material containing water having a pH of 12 to 13, a surfactant, and a basic substance, but cannot be used in the oral cavity because of its strong alkalinity, and thus is safe. I had a problem with.
- Patent Document 2 describes a composition containing cleaning particles for removing protein contaminants within the range of fixing an adhesive in a dental restorative material. Since it is a basic substance containing sodium, it cannot be used in the oral cavity and there is a problem in safety.
- Non-Patent Documents 1 and 2 describe that removal of lumps of the temporary adhesive material by an air scaler and cleaning by ultrasonic treatment may lead to a decrease in adhesive strength. Further, Non-Patent Document 2 describes that the temporary adhesive material is removed by cleaning by mechanical stimulation using a rotating brush.
- the removal method not only largely depends on the technique of the technician. In some cases, the facility is not owned in the hospital. Therefore, it is difficult to recommend it as a cleaning method, and there is a demand for a method capable of removing the temporary adhesive by a simpler process.
- the problem to be solved by the present invention is to eliminate the variation in performance by suppressing the formation of precipitates, and then to the dental restoration, and to the contamination by the protein-containing body fluid of the abutment tooth.
- the present invention is to provide a dental cleaning material that exhibits excellent cleaning properties, has excellent adhesive durability after cleaning, and is safe even when used in the oral cavity.
- another problem to be solved by the invention is a simpler method without mechanical treatment and excellent cleaning properties for temporary adhesive materials, and excellent adhesive strength after cleaning.
- the purpose of the present invention is to provide a dental temporary adhesive removal material.
- the present inventors achieved the above-mentioned object regarding the dental cleaning material by containing the acidic group-containing radically polymerizable monomer (a), water (b), and the organic amine compound (c). It has been found that the present invention can achieve the above-mentioned object regarding a temporary dental adhesive removal material by containing an acidic group-containing compound (A), water (B), and a basic compound (C). The present invention has been completed and the present invention has been achieved. That is, the present invention includes the following inventions. [1] A dental cleaning material containing an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c).
- the acidic group-containing radically polymerizable monomer (a) contains a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing ( The dental cleaning material according to [1] or [2], which contains at least one monomer selected from the group consisting of (meth) acrylic monomers.
- Dental cleaning material [10]
- the basic inorganic compound (d) is at least one selected from the group consisting of alkali metal phosphates, alkali metal hydrogen phosphates, and alkali metal dihydrogen phosphates, [8] Alternatively, the dental cleaning material according to [9].
- a method for producing a dental cleaning material which comprises a step of mixing an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c).
- the temporary adhesive removal material for dental use according to [17] which has a pH of less than 8.0.
- the acidic group-containing polymerizable monomer (A-1) contains a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing
- the dental temporary adhesive removal material according to [19] which is at least one selected from the group consisting of (meth) acrylic monomers.
- the basic compound (C) is at least one selected from the group consisting of a basic inorganic compound (C-1) and an organic amine compound (C-2).
- the basic inorganic compound (C-1) is at least one basic substance selected from the group consisting of phosphates, hydrogen phosphates, and dihydrogen phosphates.
- the basic inorganic compound (C-1) is at least one selected from the group consisting of alkali metal phosphates, alkali metal hydrogen phosphates, and alkali metal dihydrogen phosphates.
- [21] or [22] is a temporary dental adhesive removal material.
- Adhesive removal material [28] Dental use according to [26] or [27], wherein the mass ratio of the hydrophilic filler (D-1) to the hydrophobic filler (D-2) is in the range of 4: 6 to 2: 8. Temporary adhesive removal material. [29] The dental temporary adhesive removal material according to any of [25] to [28], wherein the gelling agent (D) contains a polymeric thickener (D-3). [30] The method for producing a dental temporary adhering material removal material according to [17], including a step of mixing the acidic group-containing compound (A), water (B), and the basic compound (C).
- the dental cleaning material of the present invention exhibits excellent detergency against contamination by protein-containing body fluids of dental restorations and abutment teeth, has excellent adhesive durability after cleaning, and when used in the oral cavity. Is also safe. In addition, since there is no formation of solid precipitates during storage and use, there is no risk of variations in performance or obstruction of adhesion. Furthermore, the dental cleaning material of the present invention is also excellent in antiseptic property for preventing the growth of mold and the like. Further, the temporary dental adhesive removing material of the present invention exhibits excellent cleaning properties with respect to temporary adhesives, which are temporary materials, and has excellent adhesive strength after cleaning.
- the dental cleaning material (dental cleaning material composition) of the present invention is characterized by containing an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c). ..
- the acidic group-containing radically polymerizable monomer (a), water (b), and organic amine compound (c), which are components of the dental cleaning material of the present invention, will be described below.
- the acidic group-containing radically polymerizable monomer (a) reacts with the organic amine compound (c) to form a salt, and due to the surfactant effect, the protein-containing body fluid or a substance derived from the protein-containing body fluid (for example, plaque, pellicle, etc.). ) Improve the cleaning effect against contamination.
- the acidic group-containing radical-polymerizable monomer (a) permeates the tooth substance while decalcifying and bonds with the tooth substance to improve the adhesiveness to the tooth substance. Furthermore, the acidic group-containing radically polymerizable monomer (a), when combined with the organic amine compound (c), exhibits excellent adhesion durability to the tooth substance and dental prosthesis after cleaning.
- the acidic group-containing radically polymerizable monomer (a) exhibits antiseptic properties for preventing the growth of mold and the like when combined with the organic amine compound (c).
- the acidic group-containing radically polymerizable monomer (a) has at least one acidic group such as a phosphoric acid group, a phosphonic acid group, a pyrophosphoric acid group, a carboxylic acid group, a sulfonic acid group, and an acryloyl group or a methacryloyl group.
- a polymerizable monomer having at least one radically polymerizable group such as an acrylamide group or a methacrylamide group.
- the acidic group-containing radically polymerizable monomer (a) is a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acryl. It is preferably at least one selected from the group consisting of system monomers. From the viewpoint of adhesiveness to enamel, the acidic group-containing radically polymerizable monomer (a) contains a monofunctional acidic group containing any one of an acryloyl group, a methacryloyl group, an acrylamide group and a methacrylamide group ( It is preferably a (meth) acrylic monomer. Specific examples include the following. In the present specification, methacryl and acryl are collectively referred to as “(meth) acryl”.
- Examples of the phosphoric acid group-containing (meth) acrylic monomers include 2- (meth) acryloyloxyethyl dihydrogen phosphate, 3- (meth) acryloyloxypropyl dihydrogen phosphate, and 4- (meth) acryloyloxy.
- Examples of the phosphonic acid group-containing (meth) acrylic monomer include, for example, 2- (meth) acryloyloxyethylphenylphosphonate, 5- (meth) acryloyloxypentyl-3-phosphonopropionate, and 6- (meth). Acryloyloxyhexyl-3-phosphonopropionate, 10- (meth) acryloyloxydecyl-3-phosphonopropionate, 6- (meth) acryloyloxyhexyl-phosphonoacetate, 10- (meth) acryloyloxydecyl -Phosphonoacetates, their amine salts.
- Examples of the pyrophosphate group-containing (meth) acrylic monomer include bis [2- (meth) acryloyloxyethyl] pyrophosphate, bis [4- (meth) acryloyloxybutyl] pyrophosphate, and bis [6] pyrophosphate.
- -(Meth) acryloyloxyhexyl] bis [8- (meth) acryloyloxyoctyl] pyrophosphate, bis [10- (meth) acryloyloxydecyl] pyrophosphate, and amine salts thereof.
- Examples of the carboxylic acid group-containing (meth) acrylic monomer include (meth) acrylic acid, 4- (meth) acryloyloxyethoxycarbonylphthalic acid; 4- (meth) acryloyloxyethyltrimellitic acid, 4- ( (Meth) acryloyloxybutyloxycarbonylphthalic acid, 4- (meth) acryloyloxyhexyloxycarbonylphthalic acid, 4- (meth) acryloyloxyoctyloxycarbonylphthalic acid, 4- (meth) acryloyloxydecyloxycarbonylphthalic acid and these Acid anhydride; 5- (meth) acryloylaminopentylcarboxylic acid, 6- (meth) acryloyloxy-1,1-hexanedicarboxylic acid, 8- (meth) acryloyloxy-1,1-octanedicarboxylic acid, 10- Examples thereof include (meth) acryloyl
- Examples of the (meth) acrylic monomer containing a sulfonic acid group include 2- (meth) acrylamido-2-methylpropanesulfonic acid, 2-sulfoethyl (meth) acrylate, and amine salts thereof.
- phosphoric acid group, pyrophosphoric acid group or carboxylic acid group-containing (meth) acrylic monomer is more preferable for dental restoration and tooth structure. It is preferable because it exhibits excellent adhesive strength, and a (meth) acrylic monomer containing a phosphoric acid group is particularly preferable.
- a divalent phosphoric acid group-containing (meth) acrylic monomer having an alkyl group or an alkylene group having 6 to 20 carbon atoms as a main chain in the molecule is more preferable, and 10-methacryloyloxydecyl dihydrogen is more preferable.
- a divalent phosphoric acid group-containing (meth) acrylic monomer having an alkylene group having 8 to 12 carbon atoms as a main chain in the molecule such as phosphate is most preferable.
- the acidic group-containing radically polymerizable monomer (a) may be used alone or in combination of two or more. If the content of the acidic group-containing radically polymerizable monomer (a) is too small, the effect due to the addition of the acidic group-containing radically polymerizable monomer (a) may not be obtained, and if it is too large, the A large amount of the group-containing radical-polymerizable monomer (a) remains on the dental restoration and the abutment tooth, and the curing property of the dental adhesive to be applied thereafter may be deteriorated, and the adhesive property may be deteriorated. ..
- the content of the acidic group-containing radically polymerizable monomer (a) is not particularly limited as long as the effect of the present invention is exhibited, but in the total 100 parts by mass of the dental cleaning material, the range of 0.1 to 30 parts by mass is preferable.
- the range of 0.5 to 20 parts by mass is more preferable, the range of 1.0 to 15 parts by mass is more preferable, and the range of 2.0 to 8.0 parts by mass is particularly preferable.
- the dental cleaning material according to the present invention may contain, as the polymerizable monomer, a radical-polymerizable monomer that does not contain an acidic group, in addition to the acidic-group-containing radical-polymerizable monomer (a).
- a radical-polymerizable monomer that does not contain an acidic group in addition to the acidic-group-containing radical-polymerizable monomer (a).
- the radically polymerizable monomer containing no acidic group include a radical hydrophilic polymerizable monomer containing no acidic group and a hydrophobic polymerizable monomer containing no acidic group.
- the radical hydrophilic polymerizable monomer containing no acidic group means one having a solubility in water at 25 ° C. of 10% by mass or more, preferably one having a solubility of 30% by mass or more, and an arbitrary value at 25 ° C.
- the hydrophobic polymerizable monomer containing no acidic group means one having a solubility in water at 25 ° C. of less than 10% by mass, and examples thereof include an aromatic compound-based bifunctional polymerizable monomer and an aliphatic compound. Examples thereof include crosslinkable polymerizable monomers such as compound-based bifunctional polymerizable monomers and trifunctional or higher functional polymerizable monomers.
- the dental cleaning material according to the present invention may contain an acidic group-containing organic compound (a-2) having no polymerizable group.
- the acidic group-containing organic compound (a-2) having no polymerizable group is the same as the acidic group-containing organic compound (A-2) having no polymerizable group used in the dental temporary adhesive removal material described later. Can be used.
- the content of the acidic group-containing organic compound (a-2) having no polymerizable group in the dental cleaning material according to the present invention is the same as that of the temporary dental adhesive removal material.
- Water (b) is a solvent that dissolves the organic amine compound (c) and the acidic group-containing radically polymerizable monomer (a). Further, it promotes the decalcification action of the radically polymerizable monomer (a) containing an acidic group on the tooth structure and improves the adhesiveness. It is necessary to use water (b) that does not substantially contain impurities that adversely affect the adhesiveness, and distilled water or ion-exchanged water is preferable.
- the content of water (b) is preferably in the range of 40 to 99.8 parts by mass, more preferably in the range of 50 to 99 parts by mass, and in the range of 60 to 98 parts by mass based on 100 parts by mass of the dental cleaning material. Is more preferable.
- a solvent other than water may be further added to the dental cleaning material according to the present invention.
- a more efficient cleaning effect can be expected by adjusting the viscosity of the dental cleaning material and concentrating the active ingredient by further blending a solvent other than water.
- the solvent other than water include organic solvents such as acetone and ethyl methyl ketone; ethanol, 1-propanol, 2-propanol, 2-methyl-2-propanol, glycerin, diglycerin, polyglycerin, propylene glycol, diester.
- Alcohols such as propylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, polyethylene glycol, polyethylene glycol monomethyl ether, 1,2-pentadiol, 1,2-hexanediol, and 1,2-octanediol; and the like.
- the content of the solvent other than the water (b) is not particularly limited, but in a total of 100 parts by mass of the dental cleaning material, 50 parts by mass or less is preferable, 40 parts by mass or less is more preferable, and 20 parts by mass or less is further. preferable.
- the content of the solvent other than the water (b) is preferably 100 parts by mass or less, more preferably 85 parts by mass or less, and even 60 parts by mass or less with respect to 100 parts by mass of water (b). ..
- the organic amine compound (c) brings about a cleaning effect against contamination by a protein-containing body fluid or a substance derived from the protein-containing body fluid and an improvement in solubility of the acidic group-containing radical-polymerizable monomer (a) in water, so that the organic amine compound (c) during refrigeration storage It is possible to suppress the formation of precipitates, and to impart excellent adhesive strength and adhesive durability to the dental cleaning material without variations in performance.
- a part of the organic amine compound (c) reacts with the radically polymerizable monomer (a) containing an acidic group to form a salt, and the surfactant effect further improves the cleaning effect against contamination by the protein-containing body fluid.
- the dental cleaning material contains the organic amine compound (c), it brings excellent adhesion strength and adhesion durability to the dental restoration and the tooth structure after cleaning.
- the organic amine compound (c) may contain a primary organic amine compound or a secondary organic amine compound, but preferably contains a tertiary organic amine compound from the viewpoint of suppressing side reactions.
- the organic amine compound (c) may be an aliphatic compound or an aromatic compound.
- the organic amine compound (c) is capable of imparting more excellent adhesive strength and adhesive durability to a dental cleaning material without variations in performance, and therefore an aliphatic compound having at least one hydroxyl group.
- a tertiary organic amine compound which is an aromatic compound having one or more hydroxyl groups and a tertiary organic amine compound which is an aliphatic compound having two or more hydroxyl groups, It is more preferable to contain a tertiary organic amine compound which is an aromatic compound having two or more hydroxyl groups.
- Examples of the tertiary organic amine compound which is an aliphatic compound include N-methyldiethanolamine, N-ethyldiethanolamine, Nn-butyldiethanolamine, N-lauryldiethanolamine, 2- (dimethylamino) ethylmethacrylate, N-methyl.
- Examples include diethanolamine dimethacrylate, N-ethyldiethanolamine dimethacrylate, triethanolamine monomethacrylate, triethanolamine dimethacrylate, triethanolamine trimethacrylate, triethanolamine, trimethylamine, triethylamine, tributylamine, etc.
- Triethanolamine and 2- (dimethylamino) ethyl methacrylate are more preferable because they are more excellent in strength and adhesion durability.
- Examples of the tertiary organic amine compound which is an aromatic compound include N, N-bis (2-hydroxyethyl) -3,5-dimethylaniline and N, N-bis (2-hydroxyethyl) -p-toluidine.
- the organic amine compound (c) may be used alone or in combination of two or more. If the content of the organic amine compound (c) is too small, the effect due to the blending of the organic amine compound (c) may not be obtained, and if it is too large, the basicity becomes strong and protein denaturation occurs. , The safety in the oral cavity may be reduced.
- the content of the organic amine compound (c) is not particularly limited as long as the effects of the present invention are exhibited, but from the viewpoint of the pH of the dental cleaning material (solution or suspension), the total content of the dental cleaning material is 100 parts by mass. The range of 0.1 to 20 parts by mass is preferable, the range of 0.2 to 10 parts by mass is more preferable, and the range of 0.25 to 5 parts by mass is further preferable.
- the dental cleaning material of the present invention preferably contains a basic inorganic compound (d).
- the basic inorganic compound (d) is preferably at least one basic substance selected from phosphates, hydrogen phosphates, and dihydrogen phosphates, and contains a protein even in a small amount. It provides a cleaning effect against contamination by substances derived from body fluids and protein-containing body fluids.
- a part of the basic inorganic compound (d) reacts with the radical polymerizable monomer containing an acidic group (a) to form a salt, and the surfactant effect improves the cleaning effect against contamination by the body fluid containing protein.
- the dental cleaning material contains the basic inorganic compound (d), it has excellent adhesion strength and adhesion durability to the dental restoration and the tooth structure after cleaning.
- the basic inorganic compound (d) include trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, tripotassium phosphate, dipotassium hydrogen phosphate, potassium phosphate dibasic, and the like.
- alkali metal hydrogen phosphate or alkali dihydrogen phosphate alkaline earth metal phosphates such as tricalcium phosphate, calcium hydrogen phosphate, calcium dihydrogen phosphate, alkaline earth metal hydrogen phosphate Salts or alkaline earth metal dihydrogen phosphates, such as trimagnesium phosphate, magnesium hydrogen phosphate, and the like, selected from the group consisting of alkali metal phosphates, alkali metal hydrogen phosphates and alkali metal dihydrogen phosphates It is preferably at least one selected. Among them, trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, tripotassium phosphate, dipotassium hydrogen phosphate, and potassium dihydrogen phosphate are more preferable.
- the basic inorganic compound (d) may be blended alone or in combination of two or more. If the content of the basic inorganic compound (d) is too small, the effect due to the incorporation of the basic inorganic compound (d) may not be obtained, and if it is too large, the basicity becomes strong and protein denaturation may occur. As a result, the safety in the oral cavity may be reduced. On the other hand, if the amount is too large, the basic inorganic compound (d) itself may be deposited, resulting in a decrease in operability and a sufficient washing effect for the protein-containing body fluid may not be obtained.
- the content of the basic inorganic compound (d) is not particularly limited as long as the effects of the present invention are exhibited, but from the viewpoint of the pH of the dental cleaning material (solution or suspension), the total amount of the dental cleaning material is 100 parts by mass.
- the range of 0.1 to 20 parts by mass is preferable, the range of 0.2 to 10 parts by mass is more preferable, and the range of 0.25 to 5 parts by mass is further preferable.
- the pH of the dental cleaning material of the present invention is preferably less than 8.0.
- a safer dental cleaning material having excellent adhesive strength and adhesive durability after washing and having a safety of 2.0 or more and less than 8.0 is preferable, and 2.5 or more. It is more preferably 7.5 or less, further preferably 3.0 or more and 6.5 or less, and particularly preferably 3.5 or more and 5.5 or less.
- the pH can be measured using a known measuring device. Examples of the measuring device include "LAQUA Twin" manufactured by HORIBA, Ltd.
- the dental cleaning material of the present invention preferably contains a gelling agent (e).
- the gelling agent (e) include a hydrophilic filler (e-1), a hydrophobic filler (e-2), and a polymer thickener (e-3).
- the gelling agent (e) may be used alone or in combination of two or more.
- the dental cleaning material contains a hydrophilic filler (e-1) and a hydrophobic filler (e-2) as the gelling agent (e).
- the dental cleaning material contains only polymeric thickener (e-3) as gelling agent (e).
- the dental cleaning material contains a hydrophilic filler (e-1), a hydrophobic filler (e-2) and a polymeric thickener (e-3).
- a gelling agent (e) that is a combination of all three types of hydrophilic filler (e-1), hydrophobic filler (e-2) and polymer type thickener (e-3) is used. It is preferable to contain.
- Hydrophilic filler (e-1) means a filler whose surface is not subjected to hydrophobic treatment.
- the hydrophilic filler (e-1) is a particle such as silica having a silanol group on the surface, it means a particle whose surface has no silanol group.
- the hydrophobic filler (e-2) means a filler in which the surface of the particles is hydrophobized.
- the hydrophobic filler (e-2) is a particle such as silica having a silanol group on the surface
- the silanol group on the surface is dimethylsilyl, trimethylsilyl, dimethylpolysiloxane, dimethylsiloxane, aminoalkylsilyl, methacrylsilyl.
- Particles that are hydrophobized with a substituent such as alkylsilyl Particles that are hydrophobized with a substituent such as alkylsilyl.
- the hydrophilic filler (e-1) a hydrophilic inorganic filler is preferable, and hydrophilic fumed silica is more preferable.
- the hydrophobic filler (e-2) a hydrophobic inorganic filler is preferable, and hydrophobic fumed silica is more preferable.
- the average particle size of the hydrophilic filler (e-1) and the hydrophobic filler (e-2) is not particularly limited, and is preferably 0.0001 to 50 ⁇ m, more preferably 0.001 to 10 ⁇ m, 0.001 to 1.0 ⁇ m is more preferable because it is more excellent in the coating property of the dental cleaning material.
- the average particle size of the hydrophilic filler (e-1) and the hydrophobic filler (e-2) is an average primary particle size, and is determined by a laser diffraction scattering method or electron microscopic observation of particles.
- the laser diffraction / scattering method is easy for measuring the particle diameter of particles of 0.1 ⁇ m or more, and the electron microscope observation is easy for measuring the particle diameter of ultrafine particles of less than 0.1 ⁇ m.
- 0.1 ⁇ m is a value measured by a laser diffraction scattering method.
- the laser diffraction / scattering method can be specifically measured by, for example, a laser diffraction particle size distribution analyzer (SALD-2300: manufactured by Shimadzu Corporation) using a 0.2% sodium hexametaphosphate aqueous solution as a dispersion medium. ..
- a scanning electron microscope (SU3800, S-4000, manufactured by Hitachi High-Technologies Corporation) can be used for electron microscope observation.
- Electron microscope observation is carried out by, for example, taking an electron micrograph of particles, and determining the particle size of particles (200 or more) observed in the unit field of view of the image using image analysis type particle size distribution measurement software (Mac-View). (Manufactured by Mountech Co., Ltd.). At this time, the particle diameter is obtained as an arithmetic average value of the longest length and the shortest length of the particle, and the average primary particle diameter is calculated from the number of particles and the particle diameter.
- Mac-View image analysis type particle size distribution measurement software
- hydrophilic filler (e-1) examples include hydrophilic fumed silica: fine particle silica manufactured by Nippon Aerosil Co., Ltd., AEROSIL (registered trademark) 90, AEROSIL (registered trademark) 130, AEROSIL (registered trademark) 150, AEROSIL (registered trademark) 200, AEROSIL (registered trademark) 255, AEROSIL (registered trademark) 300, AEROSIL (registered trademark) 380, AEROSIL (registered trademark) OX50, AEROSIL (registered trademark) TT600, AEROSIL (registered trademark) 200F, AEROSIL (registered trademark) 380F, AEROSIL (registered trademark) 200 Pharma, AEROSIL (registered trademark) 300 Pharma, and AEROSIL (registered trademark) 130 are preferable.
- hydrophilic fumed silica fine particle silica manufactured by Nippon Aerosil Co., Ltd.
- hydrophobic filler (e-2) examples include hydrophobic fumed silica: fine particle silica manufactured by Nippon Aerosil Co., Ltd., AEROSIL (registered trademark) R972, AEROSIL (registered trademark) R974, AEROSIL (registered trademark) R104, AEROSIL (registered trademark) R106, AEROSIL (registered trademark) R202, AEROSIL (registered trademark) R208, AEROSIL (registered trademark) R805, AEROSIL (registered trademark) R812, AEROSIL (registered trademark) R812S, AEROSIL (registered trademark) R816, AEROSIL (registered trademark) R7200, AEROSIL (registered trademark) R8200, AEROSIL (registered trademark) R9200, AEROSIL (registered trademark) R711, AEROSIL (registered trademark) R50, AEROSIL (registered trademark) NY50, AE
- the polymeric thickener (e-3) refers to a polymer that is added to a material to adjust the viscosity and improves dispersibility and thickening, and may be a natural substance or a synthetic substance. It may be a substance. Examples of natural substances include casein, methylcellulose, carboxymethylcellulose, and hydroxyethylcellulose, and examples of synthetic substances include polyvinyl alcohol, sodium polyacrylate, polyethylene oxide, polyethylene glycol, polyvinylpyrrolidone, and the like.
- polymer-based thickener (e-3) commercially available products can be used, and polyethylene glycol-based thickeners such as Macrogol 4000 (manufactured by Maruishi Pharmaceutical Co., Ltd.) and Macrogol 400 (Maruishi) Pharmaceuticals Co., Ltd.) and polyvinylpyrrolidone (manufactured by IPS Corporation). Among them, Macrogol 4000 (manufactured by Maruishi Pharmaceutical Co., Ltd.) is preferable.
- the content of the gelling agent (e) is not particularly limited as long as the effect of the present invention is exhibited, but in a total of 100 parts by mass of the dental cleaning material, a range of 0.50 to 40 parts by mass is preferable, and 0.80 to The range of 35 parts by mass is more preferable, the range of 1 to 30 parts by mass is further preferable, and the range of 4 to 25 parts by mass is particularly preferable. It is preferable that the hydrophilic filler (e-1) is hydrophilic fumed silica and the hydrophobic filler (e-2) is hydrophobic fumed silica.
- the mass ratio of the hydrophilic filler (e-1) and the hydrophobic filler (e-2) is 4: 6 to 2:
- the range of 8 is preferable, and the range of 4.3: 5.7 to 2.2: 7.8 is more preferable.
- the polymer-based thickener (e-3) from the viewpoint of suppressing the separation of the gel component and the liquid component contained in the dental cleaning material, it is 1 to 100 parts by weight in total of the dental cleaning material.
- the range of 25 parts by mass is preferable, the range of 4 to 20 parts by mass is more preferable, and the range of 8 to 17 parts by mass is further preferable.
- a fluorine ion-releasing substance for example, dibutylhydroxytoluene (BHT), hydroquinone monomethyl ether ( MEHQ)
- a colorant for example, a fluorescent agent, a fragrance, etc.
- an antibacterial substance such as cetylpyridinium chloride, benzalkonium chloride, (meth) acryloyloxidedecylpyridinium bromide, (meth) acryloyloxyhexadecylpyridinium chloride, (meth) acryloyloxydecylammonium chloride, or triclosan is added, Good.
- the radical-polymerizable monomer containing an acidic group-containing radical-polymerizable monomer (a), water (b), and an organic amine compound (c) is contained.
- the monomer (a) is selected from the group consisting of a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acrylic monomer.
- the content of the radical-polymerizable monomer (a) containing an acidic group is in the range of 0.1 to 30 parts by mass based on 100 parts by mass of the dental cleaning material containing at least one selected monomer.
- water (b) is in the range of 40 to 99.8 parts by mass
- the content of the organic amine compound (c) is in the range of 0.1 to 20 parts by mass.
- W-2 an acidic group-containing radical-polymerizable monomer (a), water (b), and an organic amine compound (c) are contained.
- the monomer (a) comprises a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acrylic monomer
- the organic amine compound (c) contains a tertiary organic amine compound, and at least 100 parts by mass of the dental cleaning material contains an acidic group-containing radical-polymerizable compound.
- the content of the monomer (a) is in the range of 0.1 to 30 parts by mass
- the content of water (b) is in the range of 40 to 99.8 parts by mass
- the content of the organic amine compound (c) is in the range.
- Dental cleaning materials with an amount in the range of 0.1 to 20 parts by weight are mentioned.
- W-3) is an acidic group-containing radical containing an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c).
- the polymerizable monomer (a) comprises a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acrylic monomer.
- the organic amine compound (c) contains a tertiary organic amine compound, the tertiary organic amine compound contains an aliphatic compound,
- the content of the acidic group-containing radically polymerizable monomer (a) is in the range of 0.1 to 30 parts by mass, and the content of water (b) is 40 to 99.
- the dental cleaning material has a range of 0.8 parts by mass and a content of the organic amine compound (c) in the range of 0.1 to 20 parts by mass.
- W-4 includes an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c), wherein the acidic group-containing radical
- the polymerizable monomer (a) comprises a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acrylic monomer.
- the organic amine compound (c) contains a tertiary organic amine compound, the tertiary organic amine compound contains an aliphatic compound and an aromatic compound, and
- the content of the radically polymerizable monomer (a) containing an acidic group is in the range of 0.1 to 30 parts by mass, and the content of water (b) is 40 to 99.
- a dental cleaning material having an amount of 8 parts by mass and a content of the organic amine compound (c) of 0.1 to 20 parts by mass is included.
- Another preferred embodiment (W-5) includes an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c), wherein the acidic group-containing radical
- the polymerizable monomer (a) contains a phosphoric acid group-containing (meth) acrylic monomer
- the organic amine compound (c) contains a tertiary organic amine compound
- the tertiary organic amine compound Contains an aliphatic compound having two or more hydroxyl groups
- the content of the radical polymerizable monomer (a) containing an acidic group is 0.1 to 30 parts by mass in 100 parts by mass in total of the dental cleaning material.
- Another preferred embodiment (W-6) includes an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c),
- the polymerizable monomer (a) comprises a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) acrylic monomer.
- the aliphatic compound is an aliphatic compound having two or more hydroxyl groups
- the aromatic compound is an aromatic compound having two or more hydroxyl groups
- an acidic group-containing radical polymerizable property is obtained.
- the content of the monomer (a) is in the range of 0.1 to 30 parts by mass
- the content of water (b) is in the range of 40 to 99.8 parts by mass
- the content of the organic amine compound (c) is in the range.
- Dental cleaning materials with an amount in the range of 0.1 to 20 parts by weight are mentioned.
- the method according to any one of the above-mentioned embodiments (W-1) to (W-6), further containing a basic inorganic compound (d), for dental use When the total amount of the cleaning material is 100 parts by mass, the content of the acidic group-containing radically polymerizable monomer (a) is in the range of 0.1 to 30 parts by mass and the content of water (b) is 40 to 99.8.
- Examples include a dental cleaning material in which the content is in the range of parts by mass, and the total content of the organic amine compound (c) and the basic inorganic compound (d) is in the range of 0.1 to 20 parts by mass.
- a gelling agent (e) is contained and an acidic group-containing radical is contained.
- the content of the polymerizable monomer (a) is in the range of 0.1 to 30 parts by mass
- the content of water (b) is in the range of 45 to 99.3 parts by mass
- the organic amine compound (c) The dental cleaning material has a content of 0.1 to 20 parts by mass and a gelling agent (e) content of 0.50 to 40 parts by mass.
- the content and type of each component can be appropriately changed based on the description of the present specification, and any component can be added, Changes such as deletion can be made.
- the method for producing a dental cleaning material of the present invention is characterized by including a step of mixing an acidic group-containing radically polymerizable monomer (a), water (b), and an organic amine compound (c).
- the mixing method and the apparatus used for mixing are not particularly limited as long as the effects of the present invention are exhibited, but when the solubility of the acidic group-containing radically polymerizable monomer (a) in water (b) is low, an organic amine compound is used.
- the acidic group-containing radical polymerizable monomer (a) is mixed, or the organic amine compound (c) is mixed with the acidic group-containing radical polymerizable monomer (a).
- the method of mixing water (b) after mixing with the above is preferable.
- the dental cleaning material contains a component other than the above-mentioned components (a) to (c) (for example, gelling agent (e)), the components (a) to (c) and the other components are included.
- the components may be combined and mixed at the same time, or the process of mixing the components may be combined with the process of mixing the components (a) to (c).
- an acidic group-containing radical-polymerizable monomer (a), water (b), and an organic amine compound (c) for removing the temporary dental adhesive are included.
- the non-therapeutic use of the dental cleaning material is as follows. Each component contained in the dental cleaning material is as described above.
- the dental cleaning material can also be used to remove temporary dental adhesive.
- the dental cleaning material can be used to remove the dental temporary adhesive as a non-therapeutic treatment of the pre-treatment of the filling and coalescing of the final restoration before the filling restoration treatment.
- an acidic group-containing radical-polymerizable monomer (a), water (b), and an organic amine compound ( The dental cleaning material containing c) is mentioned.
- the temporary dental adhesive is as described below.
- a temporary dental adhesive removal material (removal of temporary dental adhesive removal material containing an acidic group-containing compound (A), water (B), and a basic compound (C). Material composition).
- the acidic group-containing compound (A) reacts with the basic compound (C) to form a salt, and thus 1) due to a surface-active effect, a cleaning effect on an organic compound such as polyacrylic acid contained in the temporary adhesive material.
- a cleaning effect on an organic compound such as polyacrylic acid contained in the temporary adhesive material In addition to 2), it is possible to remove by washing with water because zinc ions derived from zinc oxide, which is the main component of the temporary adhesive material adsorbed on the tooth surface, can be removed by washing with water. It is considered to have a temporary adhesive removal effect.
- the acidic group-containing compound (A) a known acidic group-containing compound can be used, and examples thereof include an acidic group-containing polymerizable monomer (A-1) and an acidic group-containing organic compound having no polymerizable group.
- the compound (A-2) and the like can be preferably used, but the polymerizable monomer in the adhesive is applied while demineralizing the tooth while penetrating and binding with the tooth and applied after removing the temporary adhesive.
- the acidic group-containing polymerizable monomer (A-1) is more preferably used because the adhesiveness of the bonding material to the tooth structure can be improved by the polymerization reaction with the body component.
- the acidic group-containing polymerizable monomer (A-1) has at least one acidic group such as a phosphoric acid group, a phosphonic acid group, a pyrophosphoric acid group, a carboxylic acid group, a sulfonic acid group, and an acryloyl group or methacryloyl group. It is a polymerizable monomer having at least one polymerizable group such as a group, an acrylamide group, and a methacrylamide group.
- the acidic group-containing polymerizable monomer (A-1) is a phosphoric acid group-containing (meth) acrylic monomer, a pyrophosphoric acid group-containing (meth) acrylic monomer, and a carboxylic acid group-containing (meth) It is preferably at least one selected from the group consisting of acrylic monomers.
- the acidic group-containing polymerizable monomer (A-1) contains a monofunctional acidic group having any one of an acryloyl group, a methacryloyl group, an acrylamide group and a methacrylamide group. It is preferably a (meth) acrylic monomer. Specific examples include the following.
- the examples of the acidic group-containing polymerizable monomer (A-1) are the same as the acidic group-containing radical polymerizable monomer (a) of the dental cleaning material.
- the phosphoric acid group-, pyrophosphoric acid group- or carboxylic acid group-containing (meth) acrylic monomer exhibits better adhesiveness to tooth structure. Therefore, a phosphoric acid group-containing (meth) acrylic monomer is particularly preferable.
- the surfactant effect described in 1) above is preferably a long carbon chain in order to promote micelle formation, and the adsorption force with zinc ion described in 2) above causes steric hindrance between carbon chains. Taking into consideration, the shorter carbon chain is preferable.
- a divalent phosphoric acid group-containing (meth) acryl-based single monomer having an alkyl group or an alkylene group having 6 to 20 carbon atoms as a main chain in the molecule is used.
- a monomer is more preferable, and a divalent phosphate group-containing (meth) acrylic monomer having an alkylene group having 8 to 12 carbon atoms as a main chain in the molecule such as 10-methacryloyloxydecyl dihydrogen phosphate is preferred. Most preferred.
- Examples of the acidic group-containing organic compound (A-2) having no polymerizable group include the same acidic groups (phosphoric acid group, phosphonic acid group, pyrophosphoric acid group) as the acidic group-containing polymerizable monomer (A-1). , Carboxylic acid groups, sulfonic acid groups, etc.) can be used. Among them, for the same reason as the acidic group-containing polymerizable monomer (A-1), a divalent phosphoric acid group-containing compound having an alkyl group or an alkylene group having 6 to 20 carbon atoms as a main chain in the molecule. Is more preferable, and a divalent phosphoric acid group-containing compound having an alkylene group having 8 to 12 carbon atoms as a main chain in the molecule can be more preferably used.
- the acidic group-containing compound (A) may be used alone or in combination of two or more kinds. If the content of the acidic group-containing compound (A) is too small, the effect due to the compounding of the acidic group-containing compound (A) may not be obtained, and if the content is too large, the acidic group-containing compound (A) may be contained in the cavity and support. A large amount of the adhesive may remain on the dentures, and the curing property of the dental adhesive applied thereafter may deteriorate, resulting in a decrease in adhesiveness.
- the content of the acidic group-containing compound (A) is not particularly limited as long as the effects of the present invention are exhibited, but the range of 0.1 to 30 parts by mass is preferable in 100 parts by mass of the temporary dental adhesive removal material. The range of 0.5 to 20 parts by mass is more preferable, the range of 1.0 to 15 parts by mass is further preferable, and the range of 2.0 to 8.0 parts by mass is particularly preferable.
- the dental temporary adhesive removal material according to the present invention may contain a polymerizable monomer that does not contain an acidic group.
- the polymerizable monomer containing no acidic group include a hydrophilic polymerizable monomer containing no acidic group and a hydrophobic polymerizable monomer containing no acidic group.
- the hydrophilic polymerizable monomer containing no acidic group means one having a solubility in water at 25 ° C of 10% by mass or more, preferably one having a solubility of 30% by mass or more, and an arbitrary ratio at 25 ° C. It is more preferable that it is soluble in water.
- the hydrophobic polymerizable monomer containing no acidic group means one having a solubility in water at 25 ° C.
- a dental composition containing an acidic group-containing compound (A), water (B), and a basic compound (C) and substantially free of an acidic group-free polymerizable monomer.
- a temporary adhesive removal material can be used.
- the content of the polymerizable monomer containing no acidic group is equal to that of the polymerizable monomer contained in the dental temporary adhesive removal material. It means less than 5.0% by mass, preferably less than 1.0% by mass, and more preferably less than 0.1% by mass, based on the total amount.
- Water (B) is a solvent that dissolves the basic compound (C) and the acidic group-containing compound (A). Further, it promotes the decalcification action of the acidic group-containing compound (A) on the tooth structure and improves the adhesiveness. It is necessary to use water (B) that does not substantially contain impurities that adversely affect the adhesiveness, and distilled water or ion-exchanged water is preferable.
- the content of water (B) is preferably in the range of 40 to 99.8 parts by mass, more preferably in the range of 45 to 99.3 parts by mass, and more preferably in the range of 50 to 100 parts by mass with respect to the total amount of the temporary dental adhesive removal material.
- the range of 98 parts by mass is more preferable, and the range of 60 to 97 parts by mass is particularly preferable.
- the temporary dental adhesive removal material according to the present invention may further contain a solvent other than water in an embodiment.
- a more efficient cleaning effect can be expected by adjusting the viscosity of the composition and concentrating the active ingredient by further mixing a solvent other than water.
- the solvent other than water include organic solvents such as acetone and ethyl methyl ketone; ethanol, 1-propanol, 2-propanol, 2-methyl-2-propanol, glycerin, diglycerin, polyglycerin, propylene glycol, diester.
- Alcohols such as propylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, polyethylene glycol, polyethylene glycol monomethyl ether, 1,2-pentadiol, 1,2-hexanediol, and 1,2-octanediol; and the like.
- the content of the solvent other than the water (B) in the embodiment is not particularly limited, but is preferably 50 parts by mass or less, and more preferably 40 parts by mass or less in the total 100 parts by mass of the temporary dental adhesive removal material. , 20 parts by mass or less is more preferable.
- the content of the solvent other than the water (B) is preferably 100 parts by mass or less, more preferably 85 parts by mass or less, and even 60 parts by mass or less with respect to 100 parts by mass of water (B). ..
- the basic compound (C) used in the present invention is a basic inorganic compound (C-1) and an organic amine compound (C-2), which will be described respectively.
- the basic compound (C) one type may be blended alone, or two or more types may be blended in combination.
- the basic inorganic compound (C-1) and the organic amine compound (C-2) may be used in combination.
- the content of the basic compound (C) is not particularly limited as long as the effects of the present invention are exhibited, but from the viewpoint of the pH of the temporary dental adhesive removal material (solution or suspension), the temporary dental adhesive removal material is used.
- the range of 0.1 to 20 parts by mass is preferable, the range of 0.2 to 10 parts by mass is more preferable, the range of 0.25 to 8 parts by mass is further preferable, and the range of 0.5 to 5 The range of parts by mass is particularly preferred.
- the basic inorganic compound (C-1) is preferably at least one basic substance selected from phosphates, hydrogen phosphates, and dihydrogen phosphates. A part of the basic inorganic compound (C-1) reacts with the acidic group-containing compound (A) to form a salt, and due to the surfactant effect, a cleaning effect on the organic component and zinc oxide component contained in the temporary adhesive material. Can be improved. Furthermore, since the temporary dental adhesive removing material contains the basic inorganic compound (C-1), it has excellent adhesion strength to the tooth structure after cleaning. Examples of the basic inorganic compound (C-1) are the same as the basic inorganic compound (d) of the dental cleaning material.
- the basic inorganic compound (C-1) may be used alone or in combination of two or more. If the content of the basic inorganic compound (C-1) is too small, the effect due to the addition of the basic inorganic compound (C-1) may not be obtained, and if it is too large, the basicity becomes strong and the protein becomes As a result, the safety in the oral cavity may decrease. On the other hand, if the amount is too large, the basic inorganic compound (C-1) itself precipitates, the operability is deteriorated, and a sufficient cleaning effect for the temporary adhesive may not be obtained.
- the content of the basic inorganic compound (C-1) is not particularly limited as long as the effects of the present invention are exhibited, but from the viewpoint of the pH of the temporary dental adhesive removing material (solution or suspension), the temporary dental adhesive is removed.
- the range of 0.1 to 20 parts by mass is preferable, the range of 0.2 to 10 parts by mass is more preferable, the range of 0.25 to 8 parts by mass is further preferable, and the range of 0. A range of 5 to 5 parts by mass is particularly preferable.
- the organic amine compound (C-2) improves the solubility of the acidic group-containing compound (A) in water. Further, a part of the organic amine compound (C-2) reacts with the acidic group-containing compound (A) to form a salt, and due to the surfactant effect, washing with respect to the organic component and zinc oxide component contained in the temporary adhesive material. The effect can be further improved. Furthermore, the temporary dental adhesive removing material contains the organic amine compound (C-2), so that the dental restorative material and the tooth structure are provided with excellent durability of adhesive strength after cleaning.
- the organic amine compound (C-2) may contain a primary organic amine compound or a secondary organic amine compound, but preferably contains a tertiary organic amine compound from the viewpoint of suppressing side reactions.
- the tertiary organic amine compound may be an aliphatic compound or an aromatic compound.
- Examples of the tertiary organic amine compound that is an aliphatic compound and the tertiary organic amine compound that is an aromatic compound are the same as the examples of the tertiary organic amine compound of the organic amine compound (c) of the dental cleaning material. Is.
- the organic amine compound (C-2) may be used alone or in combination of two or more. If the content of the organic amine compound (C-2) is too small, the effect due to the compounding of the organic amine compound (C-2) may not be obtained, and if it is too large, the basicity becomes strong and protein denaturation may occur. As a result, the safety in the oral cavity may be reduced.
- the content of the organic amine compound (C-2) is not particularly limited as long as the effect of the present invention is exhibited, but from the viewpoint of the pH of the dental temporary adhesive removal material (solution or suspension), the dental temporary adhesive is used.
- the range of 0.1 to 20 parts by mass is preferable, the range of 0.2 to 10 parts by mass is more preferable, the range of 0.25 to 8 parts by mass is more preferable, and the range of 0.5 is A range of up to 5 parts by mass is particularly preferred.
- the pH of the temporary dental adhesive removal material of the present invention is preferably less than 8.0.
- a safer temporary dental adhesive removal material having excellent adhesive strength after cleaning can be obtained, preferably 3.0 or more and less than 8.0, and 3.5 or more 7 0.5 or less is more preferable, and 4.5 or more and 7.4 or less is further preferable.
- the pH can be measured using a known measuring device. Examples of the measuring device include "LAQUA Twin" manufactured by HORIBA, Ltd.
- the dental temporary adhesive removal material of the present invention preferably contains a gelling agent (D).
- the gelling agent (D) include a hydrophilic filler (D-1), a hydrophobic filler (D-2), and a polymer thickener (D-3).
- the gelling agent (D) may be used alone or in combination of two or more.
- the temporary dental adhesive removal material contains a hydrophilic filler (D-1) and a hydrophobic filler (D-2) as the gelling agent (D).
- the temporary dental adhesive removing material contains only the polymeric thickening agent (D-3) as the gelling agent (D).
- the temporary dental adhesive removal material contains a hydrophilic filler (D-1), a hydrophobic filler (D-2) and a polymeric thickener (D-3). ..
- a gel in which all three kinds of hydrophilic filler (D-1), hydrophobic filler (D-2) and polymer type thickener (D-3) are combined It is preferable to contain the agent (D).
- the dental temporary adhesive removal material gels, and a dental restoration and a tooth. It is possible to improve the ease of application to the abutment tooth such as a surface, and to bring about the effect of cleaning the organic component and the zinc oxide component contained in the temporary adhering material without impeding the surfactant effect.
- the content of the gelling agent (D) is not particularly limited as long as the effects of the present invention are exhibited, but is preferably in the range of 0.50 to 40 parts by mass based on 100 parts by mass of the temporary dental adhesive removing material, A range of 80 to 35 parts by mass is more preferable, a range of 1 to 30 parts by mass is further preferable, and a range of 4 to 25 parts by mass is particularly preferable.
- the hydrophilic filler (D-1) is hydrophilic fumed silica and the hydrophobic filler (D-2) is hydrophobic fumed silica.
- the mass ratio of the hydrophilic filler (D-1) and the hydrophobic filler (D-2) is 4: 6.
- the range of to 2: 8 is preferable, and the range of 4.3: 5.7 to 2.2: 7.8 is more preferable.
- the polymeric thickener (D-3) from the viewpoint of suppressing the separation of the gel component and the liquid component contained in the temporary dental adhering material removing material, the total amount of the temporary dental adhering material removing material is 100 parts by mass.
- the range of 1 to 25 parts by mass is preferable, the range of 4 to 20 parts by mass is more preferable, and the range of 8 to 17 parts by mass is particularly preferable.
- the temporary dental adhesive removing material of the present invention includes a fluorine ion-releasing substance, a pH adjusting agent, a polymerization inhibitor (for example, dibutylhydroxytoluene (BHT), hydroquinone, etc.) as long as the effect of the present invention is not impaired. You may mix
- a preferred embodiment (X-1) of the present invention comprises an acidic group-containing compound (A), water (B), and a basic compound (C), wherein the basic compound (C) is basic.
- the content of the acidic group-containing compound (A) in the total amount of 100 parts by mass of the temporary dental adhesive removal material containing the inorganic compound (C-1) is in the range of 0.1 to 30 parts by mass, and water ( Dental temporary adhesive removing material, wherein the content of B) is in the range of 40 to 99.8 parts by mass and the content of the basic inorganic compound (C-1) is in the range of 0.1 to 20 parts by mass.
- Another preferred embodiment (X-2) includes an acidic group-containing compound (A), water (B), and a basic compound (C), wherein the basic compound (C) is an organic amine compound ( C-2), the content of the acidic group-containing compound (A) is in the range of 0.1 to 30 parts by mass, and the content of the water (B) is 100 parts by mass.
- Examples of the temporary dental adhesive removal material have a content in the range of 40 to 99.8 parts by mass and a content of the organic amine compound (C-2) in the range of 0.1 to 20 parts by mass.
- Another preferred embodiment (X-3) contains an acidic group-containing compound (A), water (B), and a basic compound (C), wherein the basic compound (C) is basic.
- the inorganic group (C-1) and the organic amine compound (C-2) are contained, and the content of the acidic group-containing compound (A) is 0.1 to 30 in the total 100 parts by mass of the dental temporary adhesive removal material.
- the content of water (B) is in the range of 40 to 99.8 parts by mass, and the total content of the basic inorganic compound (C-1) and the organic amine compound (C-2) is Dental temporary adhesive removal material in the range of 0.1 to 20 parts by mass is included.
- the acidic group-containing compound containing the gelling agent (D) according to any one of the aforementioned embodiments (X-1) to (X-3)
- the content of (A) is in the range of 0.1 to 30 parts by mass
- the content of water (B) is in the range of 45 to 99.3 parts by mass
- the content of basic compound (C) is 0. 1 to 20 parts by mass
- the content of the gelling agent (D) in the range of 0.50 to 40 parts by mass is a temporary dental adhesive removal material.
- the content and type of each component can be appropriately changed based on the description of the present specification, and any component can be added, Changes such as deletion can be made.
- the method for producing a temporary dental adhesive removing material of the present invention is characterized by including a step of mixing an acidic group-containing compound (A), water (B), and a basic compound (C).
- the mixing method and the apparatus used for the mixing are not particularly limited as long as the effects of the present invention are exhibited, but when the solubility of the acidic group-containing compound (A) in water (B) is low, the basic compound (C) is mixed with water.
- a method of mixing the acidic group-containing compound (A) after mixing with (B) or a method of mixing the basic compound (C) with the acidic group-containing compound (A) and then mixing with water (B) is preferable. ..
- the temporary dental adhesive removing material contains a component other than the above-mentioned components (A) to (C) (for example, gelling agent (D)), it is treated as components (A) to (C).
- the other components may be combined and mixed at the same time, or the step of mixing the components may be combined with the step of mixing the components (A) to (C).
- the present invention includes embodiments in which the above configurations are variously combined within the scope of the technical idea of the present invention as long as the effects of the present invention are exhibited.
- E-2 Hydrophobic fumed silica: Fine particle silica “AEROSIL (registered trademark) R972” manufactured by Nippon Aerosil Co., Ltd. (average particle diameter: 16 nm)
- E-3 Polyvinylpyrrolidone (manufactured by IPS Corporation), Macrogol 4000 (manufactured by Maruishi Pharmaceutical Co., Ltd.)
- a preservative efficacy test was conducted in accordance with the 17th Revised Japanese Pharmacopoeia Reference Information "Preservative efficacy test method" to evaluate the antiseptic properties of dental cleaning materials.
- the test bacterial solution was prepared by culturing the test bacterial strains shown in Table 1 below according to the culture conditions of the above-mentioned preservation efficacy test method. The test bacterial solution was added to the dental cleaning material, and the viable cell count was measured 2 weeks later.
- the initial viable cell count was 10 5 CPU or more per 1 mL, and after 2 weeks, the viable cell count of all 5 species was less than 10 CPU was “ ⁇ ”, and the viable cell count of all 5 species was less than 10 5 CPU. Then, at least one kind of viable cells having a viable cell count of 10 CPU or more and less than 10 5 CPU was designated as “ ⁇ ”, and at least one kind of viable cells having a viable cell count of 10 5 CPU or more was designated as “x”.
- the obtained sample was washed with an ultrasonic cleaner (Yamato Scientific Co., Ltd.) for 5 minutes and then dried by air-blowing water on the surface of the sample.
- This zirconia sintered body was dipped in artificial saliva for 1 minute, then dried by air blow, and the prepared dental cleaning material was applied to the flat surface of the zirconia sintered body, rubbed and washed for 10 seconds, and washed with water. ..
- an adhesive tape having a thickness of about 150 ⁇ m having a round hole with a diameter of 5 mm was adhered to define the adhesion area, and the adherend was treated.
- the tensile adhesion strength of the above five adhesion test samples was measured with a universal testing machine (manufactured by Shimadzu Corporation) with the crosshead speed set to 2 mm / min.
- the values shown in Tables 3 and 4 are average values.
- the average value of the tensile adhesive strength was taken as the adhesive durability, and the variation value (SD) of the tensile adhesive strength was calculated.
- the adhesive durability is preferably 16 MPa or higher, more preferably 18 MPa or higher, and even more preferably 20 MPa or higher.
- the value (SD) of the variation in tensile adhesive strength is preferably 5 or less, more preferably 4 or less, and further preferably 2.5 or less.
- the obtained sample was washed with an ultrasonic cleaner (Yamato Scientific Co., Ltd.) for 5 minutes and then dried by air-blowing water on the surface of the sample.
- This sample was immersed in artificial saliva for 1 minute and then air blown to dry it.
- a dental cleaning material was applied to the flat surface of the sample, rubbed and washed for 10 seconds, and washed with water.
- the dental cleaning material was stored in a refrigerator at 4 ° C. for 1 week, and when a precipitate was generated, it was used for cleaning as it was.
- D-2) Hydrophobic fumed silica: Fine particle silica “AEROSIL (registered trademark) R972” manufactured by Nippon Aerosil Co., Ltd.
- D-3) Macrogol 4000 (manufactured by Maruishi Pharmaceutical Co., Ltd.)
- Examples 2-1 to 2-5 and Comparative Examples 2-1 to 2-3 As examples and comparative examples, a temporary dental adhesive removal material was prepared as follows.
- High-bond temporary cement soft (carboxylic acid-based temporary adhesive material containing zinc oxide, sodium salt of acrylic acid-tricarboxylic acid copolymer, and HY material; manufactured by Shofu Co., Ltd.)
- the labial surface of the bovine lower anterior tooth was polished under running water with (# 80) silicon carbide paper (manufactured by Nippon Kenshi Co., Ltd.) to obtain a sample in which the flat surface of dentin was exposed.
- the flat surface of the obtained sample was further polished with # 1000 silicon carbide paper (manufactured by Nihon Kenshi Co., Ltd.) under running water, and the obtained sample was cleaned by an ultrasonic cleaner (manufactured by Yamato Scientific Co., Ltd.) for 5 minutes. After washing, the surface of the sample was dried by air blowing with water.
- Dental resin cement (Kurarenori Takedental Co., Ltd., trade name "SA Cement Plus Automix (registered trademark)" was placed on the treated surface of the adherend using a mixing tip, and stainless steel was placed. One end surface (circular cross-section) of a cylindrical rod (7 mm in diameter, 2.5 cm in length) made from the product was adhered and left standing for 60 minutes. The excess dental resin cement protruding from the periphery of the stainless steel cylindrical rod was removed, and then immersed in distilled water. The sample immersed in distilled water was allowed to stand in a thermostat kept at 37 ° C. for 24 hours to prepare a sample for adhesion test. Adhesion test Five test samples were prepared in total.
- the tensile adhesion strength of the above five adhesion test sample samples was measured with a universal testing machine (manufactured by Shimadzu Corporation) with the crosshead speed set to 2 mm / min.
- the values shown in Table 5 are average values.
- the tensile adhesive strength is preferably 7 MPa or more, more preferably 7.5 MPa or more.
- the tensile adhesion strength was 8 MPa when the same adhesion operation was carried out without attaching the temporary adhesive, and the temporary adhesive removing material was removed after peeling the temporary adhesive. The result of 2 MPa was obtained when the scrubbing was carried out without applying.
- the dental cleaning material according to the present invention can be used for cleaning dental restorations and abutment teeth.
- the temporary dental adhesive removal material according to the present invention exhibits excellent cleaning properties with respect to temporary adhesives, which are temporary materials, and has excellent adhesive strength after cleaning.
Abstract
Description
[1]酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を含有する、歯科用清掃材。
[2]pHが8.0未満である、[1]に記載の歯科用清掃材。
[3]前記酸性基含有ラジカル重合性単量体(a)が、リン酸基含有(メタ)アクリル系単量体、ピロリン酸基含有(メタ)アクリル系単量体、及びカルボン酸基含有(メタ)アクリル系単量体からなる群から選択される少なくとも1種の単量体を含有する、[1]又は[2]に記載の歯科用清掃材。
[4]前記有機アミン化合物(c)が第三級有機アミン化合物を含む、[1]~[3]のいずれかに記載の歯科用清掃材。
[5]前記第三級有機アミン化合物が脂肪族化合物を含む、[4]に記載の歯科用清掃材。
[6]前記脂肪族化合物がトリエタノールアミン、及び/又は2-(ジメチルアミノ)エチルメタクリレートである、[5]に記載の歯科用清掃材。
[7]前記第三級有機アミン化合物が芳香族化合物を含む、[4]~[6]のいずれかに記載の歯科用清掃材。
[8]さらに塩基性無機化合物(d)を含有する、[1]~[7]のいずれかに記載の歯科用清掃材。
[9]前記塩基性無機化合物(d)がリン酸塩、リン酸水素塩、及びリン酸二水素塩からなる群から選択される少なくとも1種の塩基性物質である、[8]に記載の歯科用清掃材。
[10]前記塩基性無機化合物(d)が、リン酸アルカリ金属塩、リン酸水素アルカリ金属塩、及びリン酸二水素アルカリ金属塩からなる群から選択される少なくとも1種である、[8]又は[9]に記載の歯科用清掃材。
[11]さらに親水性フィラー(e-1)、疎水性フィラー(e-2)、及び高分子系増粘剤(e-3)からなる群から選択される少なくとも1種のゲル化剤(e)を含有する、[1]~[10]のいずれかに記載の歯科用清掃材。
[12]前記ゲル化剤(e)が親水性フィラー(e-1)及び疎水性フィラー(e-2)である、[11]に記載の歯科用清掃材。
[13]前記親水性フィラー(e-1)が親水性ヒュームドシリカであって、かつ前記疎水性フィラー(e-2)が疎水性ヒュームドシリカである、[12]に記載の歯科用清掃材。
[14]前記親水性フィラー(e-1)と前記疎水性フィラー(e-2)の質量比が4:6~2:8の範囲である、[12]又は[13]に記載の歯科用清掃材。
[15]酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を混合する工程を含む、歯科用清掃材の製造方法。
[16]歯科用仮着材を除去するための、酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を含有する歯科用清掃材の非治療的使用。
[17]酸性基含有化合物(A)、水(B)、及び塩基性化合物(C)を含有する、歯科用仮着材除去材。
[18]pHが8.0未満である、[17]に記載の歯科用仮着材除去材。
[19]前記酸性基含有化合物(A)が酸性基含有重合性単量体(A-1)である、[17]又は[18]に記載の歯科用仮着材除去材。
[20]前記酸性基含有重合性単量体(A-1)が、リン酸基含有(メタ)アクリル系単量体、ピロリン酸基含有(メタ)アクリル系単量体、及びカルボン酸基含有(メタ)アクリル系単量体からなる群から選択される少なくとも1種である、[19]に記載の歯科用仮着材除去材。
[21]前記塩基性化合物(C)が塩基性無機化合物(C-1)及び有機アミン化合物(C-2)からなる群から選ばれる少なくとも1種である、[17]~[20]のいずれかに記載の歯科用仮着材除去材。
[22]前記塩基性無機化合物(C-1)がリン酸塩、リン酸水素塩、及びリン酸二水素塩からなる群から選択される少なくとも1種の塩基性物質である、[21]に記載の歯科用仮着材除去材。
[23]前記塩基性無機化合物(C-1)が、リン酸アルカリ金属塩、リン酸水素アルカリ金属塩、及びリン酸二水素アルカリ金属塩からなる群から選択される少なくとも1種である、[21]又は[22]に記載の歯科用仮着材除去材。
[24]前記有機アミン化合物(C-2)が第三級有機アミン化合物を含む、[21]に記載の歯科用仮着材除去材。
[25]さらにゲル化剤(D)を含有する、[17]~[24]のいずれかに記載の歯科用仮着材除去材。
[26]前記ゲル化剤(D)が親水性フィラー(D-1)及び疎水性フィラー(D-2)を含有する、[25]に記載の歯科用仮着材除去材。
[27]前記親水性フィラー(D-1)が親水性ヒュームドシリカであって、かつ前記疎水性フィラー(D-2)が疎水性ヒュームドシリカである、[26]に記載の歯科用仮着材除去材。
[28]前記親水性フィラー(D-1)と前記疎水性フィラー(D-2)の質量比が4:6~2:8の範囲である、[26]又は[27]に記載の歯科用仮着材除去材。
[29]前記ゲル化剤(D)が高分子系増粘剤(D-3)を含有する、[25]~[28]のいずれかに記載の歯科用仮着材除去材。
[30]酸性基含有化合物(A)、水(B)、及び塩基性化合物(C)を混合する工程を含む、[17]に記載の歯科用仮着材除去材の製造方法。
MDP:10-メタクリロイルオキシデシルジハイドロジェンホスフェート
〔有機アミン化合物(c)〕
TTA:トリエタノールアミン
DEPT:N,N-ビス(2-ヒドロキシエチル)-p-トルイジン
DMAEMA:2-(ジメチルアミノ)エチルメタクリレート
〔ゲル化剤(e)〕
(e-1):親水性ヒュームドシリカ:日本アエロジル株式会社製の微粒子シリカ「AEROSIL(登録商標)130」(平均粒子径:16nm)
(e-2):疎水性ヒュームドシリカ:日本アエロジル株式会社製の微粒子シリカ「AEROSIL(登録商標)R972」(平均粒子径:16nm)
(e-3):ポリビニルピロリドン(株式会社IPSコーポレーション製)、マクロゴール4000(丸石製薬株式会社製)
実施例及び比較例として、歯科用清掃材を以下のように調製した。
下記表3及び4に記載の各成分を、表3及び4に記載の質量比で常温下において混合して歯科用清掃材を作製した。得られた歯科用清掃材は、「ティースメイト(登録商標)ディセンシタイザー 液剤」(クラレノリタケデンタル株式会社製)の容器に充填して用いた。
調製した歯科用清掃材のpHを、pHメーター(株式会社堀場製作所製「LAQUAtwin」)を用いて測定した。
歯科用清掃材を440mLの容器に充填し、4℃の冷蔵庫に1週間保存した際の析出物の生成の有無を目視で確認し、析出物が全く生成しないものを「○」、析出物が生成したものを「×」と評価した。
第十七改正日本薬局方 参考情報「保存効力試験法」に従い保存効力試験を行い、歯科用清掃材の防腐性を評価した。試験菌液は下記表1の試験菌株を前記保存効力試験法の培養条件に従って培養し調製した。歯科用清掃材に試験菌液を添加し2週間後に生菌数を測定した。初期の生菌数は1mLあたり105CPU以上であり、2週間後に5種全ての生菌数が10CPU未満であるものを「○」、5種全ての生菌数が105CPU未満であって、少なくとも1種の生菌数が10CPU以上105CPU未満であるものを「△」、少なくとも1種の生菌数が105CPU以上であるものを「×」とした。
下記表2に記載の各成分を、表2に記載の組成で常温下において混合して人工唾液を作製した。
CAD/CAMシステム用のジルコニアディスク(商品名:「カタナ(登録商標) ジルコニア」HT、クラレノリタケデンタル株式会社製)から作製した円柱状(内径12mm×高さ5mm)のジルコニア焼結体(1500℃で2時間焼成したもの)を#1000シリコンカーバイド紙(日本研紙株式会社製)で研磨して、平坦面を露出させたサンプルを得た。得られたサンプルを超音波洗浄機(ヤマト科学株式会社製)で5分間洗浄後、サンプル表面の水をエアブローすることで乾燥した。このジルコニア焼結体を人工唾液に1分間浸漬し、次いで、エアブローで乾燥した後、調製した歯科用清掃材をジルコニア焼結体の平坦面に塗布して10秒間擦り洗浄を実施し、水洗した。次いで、エアブローすることで乾燥した後、直径5mmの丸穴を有する厚さ約150μmの粘着テープを貼着し、接着面積を規定し、被着体処理面とした。
CAD/CAMシステム用のジルコニアディスク(商品名:カタナ(登録商標)ジルコニアHT、クラレノリタケデンタル株式会社製)から作製した円柱状(内径12mm×高さ5mm)のジルコニア焼結体(1500℃で2時間焼成したもの)を、ラッピングフィルムシート(株式会社スリーエム製、粒度1ミクロン)で研磨し、平坦面を露出させたサンプルを得た。得られたサンプルを超音波洗浄機(ヤマト科学株式会社製)で5分間洗浄後、サンプル表面の水をエアブローすることで乾燥した。このサンプルを人工唾液に1分間浸漬し、次いでエアブローすることで乾燥した。その後、歯科用清掃材をサンプルの平坦面に塗布して10秒間擦り洗浄を実施し水洗した。なお、この歯科用清掃材は4℃の冷蔵庫に1週間保存し析出物が生成した場合には生成したまま洗浄に用いた。次いで、エアブローすることで乾燥後、走査型電子顕微鏡(株式会社日立ハイテクノロジーズ製「SU3500」)を用いて、倍率1000倍で洗浄効果を観察し、下記の基準に基づいて評価した(n=1)。
○:洗浄後に付着物なし
×:洗浄後に付着物あり
〔酸性基含有化合物(A)〕
〔酸性基含有重合性単量体(A-1)〕
MDP:10-メタクリロイルオキシデシルジハイドロジェンホスフェート
〔塩基性化合物(C)〕
〔塩基性無機化合物(C-1)〕
Na2HPO4:リン酸水素二ナトリウム
〔有機アミン化合物(C-2)〕
TTA:トリエタノールアミン
DEPT:N,N-ビス(2-ヒドロキシエチル)-p-トルイジン
DMAEMA:2-(ジメチルアミノ)エチルメタクリレート
〔ゲル化剤(D)〕
(D-1):親水性ヒュームドシリカ:日本アエロジル株式会社製の微粒子シリカ「AEROSIL(登録商標)130」
(D-2):疎水性ヒュームドシリカ:日本アエロジル株式会社製の微粒子シリカ「AEROSIL(登録商標)R972」
(D-3):マクロゴール4000(丸石製薬株式会社製)
実施例及び比較例として、歯科用仮着材除去材を以下のように調製した。
下記表5に記載の各成分を、表5に記載の質量比で常温下において混合して歯科用仮着材除去材を作製した。得られた歯科用仮着材除去材は、「ティースメイト(登録商標)ディセンシタイザー 液材」(クラレノリタケデンタル株式会社製)の容器に充填して用いた。
ハイ-ボンドテンポラリーセメント ソフト(酸化亜鉛、アクリル酸-トリカルボン酸共重合体ナトリウム塩、及びHY材を含むカルボン酸系仮着材;株式会社松風製)
調製した歯科用仮着材除去材のpHを、pHメーター(株式会社堀場製作所製「LAQUAtwin」)を用いて測定した。
ウシ下顎前歯の唇面を流水下にて(#80)シリコンカーバイド紙(日本研紙株式会社製)で研磨して、象牙質の平坦面を露出させたサンプルを得た。得られたサンプルの平坦面を流水下にて#1000のシリコンカーバイド紙(日本研紙株式会社製)でさらに研磨し、得られたサンプルを超音波洗浄機(ヤマト科学株式会社製)で5分間洗浄後、サンプル表面の水をエアブローすることで乾燥した。仮着材として、IFU(使用説明書)に従って練和したハイ-ボンドテンポラリーセメント ソフトを象牙質サンプルの平坦面に塗布した。容器の中に蒸留水で湿らせたキムタオルを入れ、その上に前記仮着材を塗布した牛歯(象牙質)サンプルを入れて密閉し、37℃にて30分間硬化させた後、37℃水中にて1週間保管する。1週間後、取り出して仮着材を剥がし、水洗及びエアブローを行った後、仮着材が塗布されていた場所に調製した歯科用仮着材除去材を塗布して10秒間擦り洗浄を実施し、水洗した。次いで、エアブローすることで乾燥した。次いで、走査電子顕微鏡(株式会社日立ハイテクノロジーズ製「SU3500」)を用いて、倍率1000倍で洗浄効果を観察し、下記の基準に基づいて評価した(n=1)。
○:洗浄後に付着物なし
×:洗浄後に付着物あり
ウシ下顎前歯の唇面を流水下にて(#80)シリコンカーバイド紙(日本研紙株式会社製)で研磨して、象牙質の平坦面を露出させたサンプルを得た。得られたサンプルの平坦面を流水下にて#1000のシリコンカーバイド紙(日本研紙株式会社製)でさらに研磨し、得られたサンプルを超音波洗浄機(ヤマト科学株式会社製)で5分間洗浄後、サンプル表面の水をエアブローすることで乾燥した。仮着材として、IFU(使用説明書)に従って練和したハイ-ボンドテンポラリーセメント ソフトを象牙質サンプルの平坦面に塗布した。容器の中に蒸留水で湿らせたキムタオルを入れ、その上に前記仮着材を塗布した牛歯(象牙質)サンプルを入れて密閉し、37℃にて30分間硬化させた後、37℃水中にて1週間保管する。1週間後、取り出して仮着材を剥がし、水洗及びエアブローを行った後、仮着材が塗布されていた場所に調製した歯科用仮着材除去材を塗布して10秒間擦り洗浄を実施し、水洗した。次いで、エアブローすることで乾燥した後、直径3mmの丸穴を有する厚さ約150μmの粘着テープを貼着し、接着面積を規定し、被着体処理面とした。
Claims (30)
- 酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を含有する、歯科用清掃材。
- pHが8.0未満である、請求項1に記載の歯科用清掃材。
- 前記酸性基含有ラジカル重合性単量体(a)が、リン酸基含有(メタ)アクリル系単量体、ピロリン酸基含有(メタ)アクリル系単量体、及びカルボン酸基含有(メタ)アクリル系単量体からなる群から選択される少なくとも1種の単量体を含有する、請求項1又は2に記載の歯科用清掃材。
- 前記有機アミン化合物(c)が第三級有機アミン化合物を含む、請求項1~3のいずれかに記載の歯科用清掃材。
- 前記第三級有機アミン化合物が脂肪族化合物を含む、請求項4に記載の歯科用清掃材。
- 前記脂肪族化合物がトリエタノールアミン、及び/又は2-(ジメチルアミノ)エチルメタクリレートである、請求項5に記載の歯科用清掃材。
- 前記第三級有機アミン化合物が芳香族化合物を含む、請求項4~6のいずれかに記載の歯科用清掃材。
- さらに塩基性無機化合物(d)を含有する、請求項1~7のいずれかに記載の歯科用清掃材。
- 前記塩基性無機化合物(d)がリン酸塩、リン酸水素塩、及びリン酸二水素塩からなる群から選択される少なくとも1種の塩基性物質である、請求項8に記載の歯科用清掃材。
- 前記塩基性無機化合物(d)が、リン酸アルカリ金属塩、リン酸水素アルカリ金属塩、及びリン酸二水素アルカリ金属塩からなる群から選択される少なくとも1種である、請求項8又は9に記載の歯科用清掃材。
- さらに親水性フィラー(e-1)、疎水性フィラー(e-2)、及び高分子系増粘剤(e-3)からなる群から選択される少なくとも1種のゲル化剤(e)を含有する、請求項1~10のいずれかに記載の歯科用清掃材。
- 前記ゲル化剤(e)が親水性フィラー(e-1)及び疎水性フィラー(e-2)である、請求項11に記載の歯科用清掃材。
- 前記親水性フィラー(e-1)が親水性ヒュームドシリカであって、かつ前記疎水性フィラー(e-2)が疎水性ヒュームドシリカである、請求項12に記載の歯科用清掃材。
- 前記親水性フィラー(e-1)と前記疎水性フィラー(e-2)の質量比が4:6~2:8の範囲である、請求項12又は13に記載の歯科用清掃材。
- 酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を混合する工程を含む、歯科用清掃材の製造方法。
- 歯科用仮着材を除去するための、酸性基含有ラジカル重合性単量体(a)、水(b)、及び有機アミン化合物(c)を含有する歯科用清掃材の非治療的使用。
- 酸性基含有化合物(A)、水(B)、及び塩基性化合物(C)を含有する、歯科用仮着材除去材。
- pHが8.0未満である、請求項17に記載の歯科用仮着材除去材。
- 前記酸性基含有化合物(A)が酸性基含有重合性単量体(A-1)である、請求項17又は18に記載の歯科用仮着材除去材。
- 前記酸性基含有重合性単量体(A-1)が、リン酸基含有(メタ)アクリル系単量体、ピロリン酸基含有(メタ)アクリル系単量体、及びカルボン酸基含有(メタ)アクリル系単量体からなる群から選択される少なくとも1種である、請求項19に記載の歯科用仮着材除去材。
- 前記塩基性化合物(C)が塩基性無機化合物(C-1)及び有機アミン化合物(C-2)からなる群から選ばれる少なくとも1種である、請求項17~20のいずれかに記載の歯科用仮着材除去材。
- 前記塩基性無機化合物(C-1)がリン酸塩、リン酸水素塩、及びリン酸二水素塩からなる群から選択される少なくとも1種の塩基性物質である、請求項21に記載の歯科用仮着材除去材。
- 前記塩基性無機化合物(C-1)が、リン酸アルカリ金属塩、リン酸水素アルカリ金属塩、及びリン酸二水素アルカリ金属塩からなる群から選択される少なくとも1種である、請求項21又は22に記載の歯科用仮着材除去材。
- 前記有機アミン化合物(C-2)が第三級有機アミン化合物を含む、請求項21に記載の歯科用仮着材除去材。
- さらにゲル化剤(D)を含有する、請求項17~24のいずれかに記載の歯科用仮着材除去材。
- 前記ゲル化剤(D)が親水性フィラー(D-1)及び疎水性フィラー(D-2)を含有する、請求項25に記載の歯科用仮着材除去材。
- 前記親水性フィラー(D-1)が親水性ヒュームドシリカであって、かつ前記疎水性フィラー(D-2)が疎水性ヒュームドシリカである、請求項26に記載の歯科用仮着材除去材。
- 前記親水性フィラー(D-1)と前記疎水性フィラー(D-2)の質量比が4:6~2:8の範囲である、請求項26又は27に記載の歯科用仮着材除去材。
- 前記ゲル化剤(D)が高分子系増粘剤(D-3)を含有する、請求項25~28のいずれかに記載の歯科用仮着材除去材。
- 酸性基含有化合物(A)、水(B)、及び塩基性化合物(C)を混合する工程を含む、請求項17に記載の歯科用仮着材除去材の製造方法。
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AU2019384784A AU2019384784A1 (en) | 2018-11-20 | 2019-11-19 | Dental Cleaner and Dental Remover for Temporary Adhesives |
CN201980076512.7A CN113179629A (zh) | 2018-11-20 | 2019-11-19 | 牙科用清洁材料和牙科用临时粘合材料去除材料 |
EP19886511.5A EP3884920A4 (en) | 2018-11-20 | 2019-11-19 | DENTAL CLEANING MATERIAL AND DENTAL TEMPORARY ADHESIVE REMOVING MATERIAL |
US17/295,796 US20220008314A1 (en) | 2018-11-20 | 2019-11-19 | Dental cleaner and dental remover for temporary adhesives |
CA3120550A CA3120550A1 (en) | 2018-11-20 | 2019-11-19 | Dental cleaner and dental remover for temporary adhesives |
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JP2018218485A JP7219596B2 (ja) | 2018-11-21 | 2018-11-21 | 歯科用仮着材除去材 |
JP2018-218485 | 2018-11-21 | ||
JP2019122136A JP7428482B2 (ja) | 2018-11-20 | 2019-06-28 | 歯科用清掃材 |
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