WO2020093206A1 - Kit de soins de la peau - Google Patents

Kit de soins de la peau Download PDF

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Publication number
WO2020093206A1
WO2020093206A1 PCT/CN2018/113992 CN2018113992W WO2020093206A1 WO 2020093206 A1 WO2020093206 A1 WO 2020093206A1 CN 2018113992 W CN2018113992 W CN 2018113992W WO 2020093206 A1 WO2020093206 A1 WO 2020093206A1
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WO
WIPO (PCT)
Prior art keywords
composition
weight
kit according
agent
acid
Prior art date
Application number
PCT/CN2018/113992
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English (en)
Inventor
Yilin YU
Original Assignee
L'oreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L'oreal filed Critical L'oreal
Priority to CN201880100592.0A priority Critical patent/CN113226248A/zh
Priority to PCT/CN2018/113992 priority patent/WO2020093206A1/fr
Priority to PCT/CN2019/078018 priority patent/WO2020001069A1/fr
Priority to CN201980043523.5A priority patent/CN112334124A/zh
Publication of WO2020093206A1 publication Critical patent/WO2020093206A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application

Definitions

  • the present invention relates to a cosmetic system, especially to a kit caring for keratin materials, and in particular the skin. Further, the present invention relates to use of same, especially as a mask for caring for keratin materials, especially the skin.
  • compositions for caring for keratin materials in particular the skin
  • masks are known to have high penetration efficacy on the keratin materials.
  • a two-digit market growth of mask cosmetic products in China was seen.
  • paste type In general, there are four types of masks, i.e., paste type, peel-off type, gel type, and wet tissue type.
  • paste type and peel-off type masks are mainly used for cleansing of the keratin materials, whereas gel type and wet tissue type masks are more often used for caring for the skin.
  • water soluble active agents in the gel or tissue masks.
  • water soluble active agents are generally less stable in solvated state, e.g., in aqueous solution, compared with the dry form thereof, thus impacting the cosmetic effect thereof.
  • some water soluble vitamins such as ascorbic acid (also known as vitamin C)
  • vitamin C is more readily to be reacted in aqueous solution.
  • vitamin C tends to be hydrolyzed.
  • compositions for caring for the keratin materials to dispense water soluble active agents more effectively, in particular for a composition comprising a solvent.
  • compositions for caring for the keratin materials, in particular the skin with an improved easy usage.
  • masks which is capable of texture transformation, for example, from tissue to gel, creating a pleasant consumer experience.
  • masks which have a moisture or actives such as whitening agent delivery capacity that is at least on par with or even greater than that observed with wet tissue type masks.
  • the present inventors discovered that the conception or gist of the present invention is applicable not only to the cosmetic field, but also to other fields like the medical field, then the masks of the preceding aspects may be broadened to kits, which show the benefits described herein in connection with these masks as well.
  • a specific combination of: 1) a first composition comprising at least one water insoluble substrate; 2) a second composition comprising a water soluble active agent and a disintegrating agent in dry form may satisfy one or more of the abovementioned requirements.
  • kit 1 comprising the first composition and the second composition separately placed from one another.
  • kits 2 comprising the first composition comprising at least one polyvalent metal ion, the second composition, and a third composition comprising at least one water soluble gelatinizing agent, which is gelatinizable with the polyvalent metal ion.
  • kits 1 and/or 2 for caring for the keratin materials, especially the skin.
  • This use may manifest itself as a process for caring for the keratin materials, especially the skin, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to said keratin materials the thus obtained mixture.
  • kits 1 and/or 2 for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, and so on.
  • This use may manifest itself as a process for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, comprising the steps of compounding the first composition and the second composition of the kit at a predetermined weight ratio, and then applying to a location in need of the thus obtained mixture.
  • the “keratin material” is the skin.
  • skin we intend all the body skin.
  • the keratin material is the face, or the neck, especially the face.
  • topical application it meant that the composition is applied or spread onto the surface of the keratin materials, such as at least one zone of the skin.
  • rinse off it is meant a composition which after being applied on the skin for a predetermined period of time, is removed from the skin by a rinsing composition such as water.
  • alkali metal refers to an element located in Group IA of the periodic table, such as sodium, potassium, lithium or a combination thereof, preferably sodium, potassium or a combination thereof.
  • water-soluble or water-dispersible means a compound which, when introduced into water at 25°C, at a mass concentration equal to 1%, make it possible to obtain a macroscopically homogeneous and transparent solution, i.e. a solution with a maximum light transmittance value, at a wavelength equal to 500 nm, through a sample 1 cm thick, of at least 60%and preferably of at least 70%.
  • the kit comprises a first composition and a second composition.
  • the first composition according to the present invention comprises at least one water insoluble substrate.
  • water insoluble means that the substrate is not dissolvable in water, nor does it break apart upon immersion in water.
  • the substrate may be a woven or nonwoven fabric made of a fiber chosen from natural fibers such as alginate, cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, and synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers, or a mixture thereof. Two or more selected from the other fibers may be used in combination.
  • the substrate can be made into a wide variety of shapes and forms such as flat pads, thick pads, thin sheets of irregular thickness, depending on the desired use and characteristic of the kit.
  • the substrate is typically designed to fit the area of the skin in the case of mask to which topical application is desired.
  • the substrate is designed to correspond to the shape of the face avoiding the eye, nostril, and mouth areas, as necessary.
  • Non-limiting examples of the substrates useful in the present invention are described, for example, in the patent application WO 02/062132, or EP 2489286A.
  • the water insoluble substrate or the fabric may comprise the water insoluble alginate fiber, especially calcium alginate fiber, in an amount ranging from 10%to 100%by weight, especially from 15%to 50%by weight, relative to the total weight of the water insoluble substrate or the fabric.
  • the water insoluble substrate or the fabric may comprise the at least one other fiber in an amount ranging from 0%to 90%by weight, especially from 50%to 85%by weight, relative to the total weight of the water insoluble substrate or the fabric.
  • a suitable nonwoven fabric made of 20%by weight of calcium alginate fiber and 80%by weight of lyocell fiber, relative to the total weight of the tissue, which is commercially available from the Sanjiang company under the name M762R-40CN.
  • alginate in particular means a salt of alginic acid.
  • Alginic acid a natural substance obtained from brown algae or from certain bacteria, is a polyuronic acid composed of two uronic acids linked together via 1, 4-glycoside bonds: ⁇ -D-mannuronic acid (M) and ⁇ -L-glucuronic acid (G) .
  • water insoluble means that the salt is not dissolvable in water, nor does it break apart in the bulk state upon immersion in water.
  • water insoluble alginates may be formed from alginic acid and some polyvalent cation, especially calcium, barium, strontium, zinc, copper, manganese, lead, cobalt, nickel, aluminum, or mixtures thereof. More specifically, the at least one water insoluble alginate may be chosen from calcium alginate, barium alginate, strontium alginate, zinc alginate, copper alginate, manganese alginate, lead alginate, cobalt alginate, nickel alginate, aluminium alginate or a mixture thereof, preferably calcium alginate.
  • Water insoluble alginates in which the principal cation is calcium, are specifically found in the fronds and stems of seaweeds of the class Phaeophyceae, examples of which are Fucus vesiculosus, Fucus spiralis, Ascophyllum nodosum, Macrocystis pyrifera, Alaria esculenta, Eclonia maxima, Lessonia nigrescens, Lessonia trabeculata, Laminaria japonica, Durvillea antarctica, Laminaria hyperborea, Laminaria longicruris, Laminaria digitata, Laminaria saccharina, Laminaria cloustoni, and Saragassum sp.
  • Suitable water insoluble alginates have a weight-average molecular weight of about 20,000 Daltons to about 500,000 Daltons.
  • the weight-average molecular weight is calculated by first determining the intrinsic viscosity, then using the Mark-Houwink Sakurada Equation, as in Martinsen, et al, "Comparison of Different Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates” (Carbohydr. Polym., 15, 171-193, 1991) .
  • the at least one water insoluble alginate may be present in form of powder, particulate, fiber or bulk state, preferably fiber.
  • the term "particulate" means that the alginate is in the form of particles.
  • the first composition of the present invention may comprise the at least one water insoluble alginate in a content ranging from 10%to 100%by weight, especially from 15%to 50%by weight, relative to the total weight of the first composition.
  • the first composition may comprise at least one superabsorbent material.
  • the at least one superabsorbent material may be present in form of powder, particulate, fiber or bulk state.
  • the superabsorbent material advantageously presents very great ability to absorb a liquid, and in particular water. In particular, it may present the capacity to absorb 15 times, or even 20 times to 50 times its own weight in water, e.g. about 25 times to 30 times.
  • the capacity of the superabsorbent material for absorbing liquid can be determined by implementing the following method.
  • M D dry state
  • the superabsorbent material is obtained in the "dry" state by being treated in a drying oven for about 4 hours (h) at about 50°C.
  • Water (or any other liquid that is to be absorbed by the material) is put into contact with the material. This can be done either by immersing the material in the liquid, or else by pouring the liquid onto the material. For example, the material may be immersed for a duration of about 1 minute (min) .
  • the quantity of water (or liquid) is used in excess so as to saturate the material completely, for example.
  • the excess water (or liquid) is then eliminated, e.g. by drip-drying for about 2 min, and the material saturated in liquid is weighed (M L ) .
  • the difference ⁇ between the weight of the material when saturated in liquid and the weight of the material when dry represents the quantity of liquid that it has absorbed, which weight is compared with the dry weight of the material.
  • the resulting value C is indicative of the capacity of the superabsorbent material to absorb the liquid, e.g. expressed in grams of liquid absorbed per gram of dry material:
  • the superabsorbent material may be selected from cellulose derivatives, alginates (not including the water insoluble alginates and the alkali metal alginic compounds described herein) and derivatives thereof, in particular derivatives such as propylene glycol alginate, or salts thereof, derivatives of polyacrylic acid or polymethacrylic acid, derivatives of poly (meth) acrylamide, derivatives of polyvinylpyrrolidone, derivatives of poly-vinyl ether, and mixtures thereof, amongst others.
  • alginates not including the water insoluble alginates and the alkali metal alginic compounds described herein
  • derivatives thereof in particular derivatives such as propylene glycol alginate, or salts thereof, derivatives of polyacrylic acid or polymethacrylic acid, derivatives of poly (meth) acrylamide, derivatives of polyvinylpyrrolidone, derivatives of poly-vinyl ether, and mixtures thereof, amongst others.
  • the superabsorbent material may be selected from derivatives of chemically modified cellulose.
  • it may be selected from carboxy-methyl cellulose, sodium carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, carboxyethyl cellulose, hydroxyethyl cellulose, hydroxyethylethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, sodium methyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.
  • alkyl celluloses may also be selected from alkyl celluloses. These polymers are obtained by grafting an alkyl residue onto one or more hydroxy groups of the cellulose polymer to form the hydroxyalkyl derivative. These alkyl residues may be selected from the following groups: stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl, palmityl, oleyl, linonyl, ricinolyl, behenyl, and mixtures thereof. These hydroxyalkyl cellulose derivatives may also be subjected to chemical modification, e.g. using a carboxylic residue.
  • the superabsorbent material may also be selected from natural polymer derivatives, such as, for example, gelatin and glucomannan and galactomannan polysaccharides extracted from seeds, vegetable fibers, fruit, seaweed, starch, plant resins, or indeed of microbial origin.
  • natural polymer derivatives such as, for example, gelatin and glucomannan and galactomannan polysaccharides extracted from seeds, vegetable fibers, fruit, seaweed, starch, plant resins, or indeed of microbial origin.
  • it may be selected from agar gum, guar gum, gum tragacanth, carrageenan gum, konjac gum, locust bean gum, gellan gum, xanthan gum, and mixtures thereof.
  • the first composition of the present invention may comprise the at least one superabsorbent material in a content ranging from 0%to 90%by weight, especially from 50%to 85%by weight, or even the rest in addition to the alignate, relative to the total weight of the first composition.
  • the kit 1 comprises, in addition to the first composition (e.g. the water insoluble substrate) , a second composition.
  • the second composition after dissolution in aqueous solution, impregnates, coats or is otherwise in contact with the first composition, so as to dispense the active agents from the second composition onto the substrate homogeneously.
  • the weight ratio of the first composition (e.g. the water insoluble substrate or the fabric) to the second composition ranges from 10: 1 to 1: 10, preferably from 5: 1 to 1: 5, or preferably from 2: 1 to 1: 2.
  • the second composition according to the present invention comprises a water soluble active agent and a disintegrating agent, both in dry from, preferably in anhydrous form.
  • An active agent is one capable of bringing cosmetic effect to a user, especially to the skin, e.g., to face.
  • Such cosmetic effect can be, for example, whitening, anti-aging, hydrating, and/or moisturizing.
  • the active agents conventionally useful for a cosmetic product can be used in the second composition according to the present invention, as long as it is water soluble.
  • composition of the present invention is particularly applicable to use water soluble active agents which are unstable in solvated state.
  • unstable we intend to mean an ingredient or composition undergoes significant change in its structure or properties within 2 months, or preferably 1 month, in solvent or solvated state. Such change may be any one undesirable for the cosmetic use, including, but not limited to, color change, degradation, decomposition, reaction with others, significant evaporation, deposition, crystallization, and the like.
  • water insoluble active agents mentions can be made of water soluble vitamins.
  • Water soluble vitamins can be used in the second composition as an active agent.
  • the useful examples of vitamin comprise vitamin C (ascorbic acid) , vitamin B group (e.g., vitamin B5 (panthenol) , vitamin B3 (niacinamide) , vitamin B1 and vitamin B2) , nicotinic acid, folic acid, pantothenic acid, the derivatives of these vitamins (in particular esters) and their mixtures.
  • vitamin C and vitamin B groups are preferably used.
  • Vitamin C is more preferably used.
  • vitamins that are suitable for use in the present invention may be represented, for example, by the products sold under the name ASCORBIC ACID 100 MESH, available from CSPC WEISHENG PHARMACEUTICAL, or from BASF.
  • Useful derivatives of water soluble vitamins comprise preferably 3-o-ethyl ascorbic acid, ascorbyl glucoside, or a mixture thereof.
  • the second composition of the present invention may comprise the at least one water soluble active agent in a content ranging from 20%to 99.9%by weight, preferably from 40%to 95%by weight, especially from 50%to 90%by weight, relative to the total weight of the second composition.
  • a disintegrating agent is used in the second composition, for the purpose of facilitating the disintegration of the water soluble active agent (s) when it is dissolved in a solvent, e.g., in water. Accordingly, the disintegrating agent is preferably mixed homogenously with the water soluble active agent.
  • the disintegrating agent is itself a binder for the active agent, or an additional binder is added, such that the disintegrating agent and the active agent is together formed into integrated solid state, e.g., particles, granules, spheres, beads, balls, bars, strips or the like, in either hollow or solid form.
  • integrated solid state e.g., particles, granules, spheres, beads, balls, bars, strips or the like.
  • the forms of granules, spheres, balls and the like are preferred.
  • the disintegrating agent is preferably selected from the group consisting of starches, e.g., corn starch, tomato starch, or wheat starch; a derivative of starch, e.g., pregelatinized starch, alpha starch, acrylic grafted starch or carboxymethyl starch sodium; saccharide or saccharide alcohol, or mixtures thereof.
  • Saccharide or saccharide alcohol is preferably used as disintegrating agent according to the present invention. More preferably, saccharide or saccharide alcohol serves itself as a binder. Useful saccharides comprise monosaccharide, disaccharide and polysaccharide. The corresponding alcohol of the saccharide may also be useful.
  • saccharides that are suitable for use in the present invention may be represented, for example, by the products sold under the name SUCRE SEMOULE SURFINE 250 from TEREOS.
  • the second composition comprising an integrated solid state thereof is preferably produced into particles, preferably in forms of granules, spheres, balls and the like.
  • Process to produce the integrated solid state comprises fluidized bed process, extrusion process, spray process, centrifugal process and others.
  • a fluidized bed process is preferred.
  • the fluidized bed process can be conducted at a temperature from room temperature to an elevated temperature, e.g., about 25 to about 80°C, about 30 to 50°C, e.g., about 35°C.
  • the particles of the integrated solid state of the active agent and disintegrating agent through the steps of:
  • the active agent is provided as particles, e.g., in form of powders, granules, spheres, or balls, for step 1) . If an additional binder is used, it is dissolved together with the disintegrating agent in step 2) .
  • an integrated process of centrifugal-fluidized bed is preferably used, wherein centrifugal force is introduced into the fluidized bed.
  • a vessel storing the active agent is placed in a fluidized bed, and a rotary plate having a diameter slightly less than that of the fluidized bed is installed at the bottom of a fluidized bed, such that a gap is formed between the outer edge of the plate and the inner wall of the fluidized bed, through which gap fluidizing gas is blowing upward.
  • Nozzles are immersed in particles of the active agent.
  • the particles of the active agent sprayed with the disintegrating agent and optionally the bind move to the edge of the plate due to centrifugal force, and is fluidized by the fluidizing gas, during which gravity also applies to the particles.
  • the rotary plate is preferably rotated at a line speed, at the outer edge of the plate, of 100-2000 m/min, preferably 300-1800 m/min, or 500-1500 m/min.
  • the high speed may be lowered, e.g., to 1000-2000 m/min, preferably 1300-1900 m/min; whilst when relatively bigger particles are needed, the high speed may be lowered, e.g., to 100-1000 m/min, preferably 200-700 m/min.
  • the integrated state of the disintegrating agent and the active agent is preferably a particle having a particle size of 20-40 mesh; a max loss of drying of less than 10%, preferably less than 5%, e.g., about 4%; and/or a bulk density between about 500 and 900kg/m 3 .
  • the weight ratio of the disintegrating agent to the active agent in the second composition ranges from 1: 100 to 1: 4, preferably from 1: 50 to 1: 5, or preferably from 1: 20 to 1: 10.
  • the second composition may comprise cosmetically useful other components, as long as the rapid dissolution of the second composition in water is not interfered.
  • a filler with a high solubility in water may be added into the second composition.
  • the dissolving speed of the filler is higher than that of the active agent.
  • the second composition can comprise a binder additional to and different from the disintegrating agent used, as long as the rapid dissolution of the second composition in water is not interfered.
  • the examples of binder can comprise polyvinyl alcohol, sodium alginate, xanthan and agar.
  • kit 1 comprises the first and second compositions. As the active agent is kept in dry form, the activity thereof is maintained as high as possible.
  • the first and second compositions are separately placed from one another in kit 1.
  • the second composition is added into appropriate amount of a solvent, e.g., water, for dissolving the active agent.
  • a solvent e.g., water
  • the active agent is dissolved very rapidly.
  • the solution of the active agent is applied to the water insoluble substrate of the first composition, e.g., through immersing the substrate in the solution, injecting the solution into the substrate, spraying the solution onto the substrate, or the like.
  • the first and second compositions are placed in a same package. Immediately before use, the first and second compositions are together added, e.g. immersed, in a solvent, e.g., water.
  • the second composition can be dissolved very rapidly for most cosmetic uses, e.g., within 3 minutes, preferably in 120 seconds, more preferably in 100 seconds.
  • the substrate of the first composition comprises fiber of water insoluble alginate, e.g., calcium alginate.
  • a gelatinization occurs. Still thanks to the promotion of dissolution of the active agent by the disintegrating agent, dissolution of active agent will be completed rapidly, well before the significant increase of viscosity due to the gelatinization. Accordingly, even for such a gelatinizing system, active agents can still be dispensed onto the substrate.
  • a third composition can be further used for the product.
  • the third composition of the present invention comprises at least one aqueous phase, and at least one water soluble gelatinizing agent, which is gelatinizable with the polyvalent metal ion. More preferably, the third composition comprises: a) . at least one aqueous phase, b) at least one water soluble gelatinizing agent, which is gelatinizable with the polyvalent metal ion, and c) at least one water soluble chelating agent of the polyvalent metal ion.
  • the water insoluble polyvalent metal ion donator reacts with the gelatinizing agent in solution and releases the polyvalent metal ions, so as to form a gel.
  • the third composition comprises both components b) and c) above
  • the water insoluble polyvalent metal ion donator reacts with the gelatinizing agent in solution and releases the polyvalent metal ions, most of which would be otherwise trapped by the water soluble chelating agent.
  • a few of free polyvalent metal ions in the solution react with the water soluble gelatinizing agent and start to gelatinize on the tissue surface.
  • the concentration of free polyvalent metal ions decreases over time, the chelated polyvalent metal ions would be gradually released and then gelatinize on the tissue surface. After a short period of time, transformation of tissue texture and a homogeneous gel on the tissue surface would be observed.
  • the third composition according to the present invention comprises at least one water soluble chelating agent of the polyvalent metal ion, to facilitate the texture transformation, and specially, to boost at least the moisture or actives delivery capacity.
  • the water soluble chelating agent of the polyvalent metal ion is water-soluble.
  • the water insoluble polyvalent metal ion donator releases few or more of the polyvalent metal ions into solution.
  • Both the chelating agent of the polyvalent metal ion and the water soluble gelatinizing agent are capable of being combined with the polyvalent metal ions.
  • the specific chelating agent according to the present invention conquers the gelatinizing agent in the competition of combination with the polyvalent metal ion, such that most of polyvalent metal ions released are trapped by the water soluble chelating agent. There are still a few of free polyvalent metal ions in the solution react with the water soluble gelatinizing agent and start to gelatinize on the tissue surface. As the concentration of free polyvalent metal ions decreases over time, the chelated polyvalent metal ions would be gradually released and then gelatinize on the tissue surface. That is, the specific chelating agent according to the present invention serves as a reservoir of the polyvalent metal ions for the gelatinization on the tissue surface.
  • the useful chelating agent of the polyvalent metal ion comprises aminocarboxylic acids, e.g., elhylenediamine tetraacetic acid (EDTA) , aminotriacetic acid, diethylene triaminepentaacetic acid, and in particular the alkali metal salt thereof, e.g., N, N-bis (carboxymethyl) glutamic acid, tetrasodium EDTA, tetrasodium salt of N, N-bis (carboxymethyl) glutamic acid (glutamic acid diacetic acid, GLDA) ; hydroxyl carboxylic acids, e.g., citric acid, tartaric acid, glucuronic acid, succinic acid, ethylenediamine disuccinic acid (EDDS) , and in particular the alkali metal salt thereof; hydroxyl aminocarboxylic acids, e.g., hydroxyethylethylenediamine triacetic acid (HEDTA) ,
  • EDTA
  • the at least one water soluble chelating agent of the polyvalent metal ion is an alkali metal hydroxyl polycarboxylate represented by an alkane containing from 1 to 4 carbon atoms, preferably containing 2 or 3 carbon atoms, substituted by 1, 2, or 3 hydroxyl groups (-OH) , preferably by one (1) hydroxyl group, and further substituted by 2, 3, 4 or 5 carboxylate groups (-COOM) , preferably by 2 or 3 carboxylate groups (-COOM) , wherein the multiple groups M independently represent H or alkali metal, with the proviso that at least one of the groups M represents alkali metal, such as Na, K or Li, preferably all groups M represent alkali metal, such as Na, K or Li, preferably Na.
  • alkali metal hydroxyl polycarboxylate represented by an alkane containing from 1 to 4 carbon atoms, preferably containing 2 or 3 carbon atoms, substituted by 1, 2, or 3 hydroxyl groups (-OH) , preferably
  • the at least one alkali metal hydroxyl polycarboxylate may be chosen from sodium tartrates, sodium citrates, potassium tartrates, potassium citrates, and hydrates thereof, preferably sodium citrates, in particularly trisodium citrate.
  • sodium citrates are used to indicate monosodium citrate, disodium citrate and trisodium citrate, and other alkali metal hydroxyl polycarboxylates may be understood in a similar way.
  • the alkali metal mentioned above is preferably sodium or potassium, in particular sodium.
  • preferable chelating agents can comprise sodium citrate, tetrasodium EDTA, tetrasodium GLDA, trisodium EDDS, sodium phytate, or a mixture thereof.
  • the third composition of the present invention may comprise the at least one water soluble chelating agent of the polyvalent metal ion in a content ranging from 0.1%to 1%by weight, especially from 0.2%to 0.4%by weight, relative to the total weight of the third composition.
  • the third composition according to the present invention comprises at least one water soluble gelatinizing agent, which is gelatinizable with the polyvalent metal ion, to form a gel.
  • water soluble gelatinizing agent specifically means one gelatinizable with the polyvalent metal ion from the first composition.
  • the water insoluble polyvalent metal ion donator releases few or more of the polyvalent metal ions into solution. Accordingly, gel is formed between the ions and the gelatinizing agent.
  • the gelatinizing agent is specifically selected to have an ability of combining with the polyvalent metal ions lower than that of the chelating agent, such that the gelatinizing agent does not combine the free polyvalent metal ions released directly from the first composition, but combines with the polyvalent metal ions subsequently from the reservoir, i.e., the chelated polyvalent metal ions. Accordingly, a gel on the surface of the first composition can be formed.
  • the gelatinizing agent can thus be anyone gelatinizable with the polyvalent metal ion, but has an ability of combining with the polyvalent metal ions lower than that of the chelating agent.
  • the gelatinizing agent can comprise glutins, pectins, gellan gum, carrageenans, agars, alginic compounds and in particular alkali metal salts of alginic acid, e.g., sodium alginate, and mixtures thereof.
  • Pectins are linear polymers of ⁇ -D-galacturonic acid (at least 65%) linked in positions 1 and 4 with a certain proportion of carboxylic groups esterified with a methanol group. About 20%of the sugars constituting the pectin molecule are neutral sugars (L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose) . L-Rhamnose residues are found in all pectins, incorporated into the main chain in positions 1, 2.
  • Uronic acid molecules bear carboxyl functions. This function gives pectins the capacity for exchanging ions, when they are in COO - form. Divalent ions (in particular calcium) have the capacity of forming ionic bridges between two carboxyl groups of two different pectin molecules.
  • a certain proportion of the carboxylic groups are esterified with a methanol group.
  • the natural degree of esterification of a pectin may range between 70% (apple, lemon) and 10% (strawberry) depending on the source used.
  • pectins with a high degree of esterification it is possible to hydrolyse the-COOCH 3 groups, so as to obtain weakly esterified pectins.
  • the chain is thus more or less acidic.
  • HM (high-methoxy) pectins are thus defined as having a degree of esterification of greater than 50%
  • LM (low-methoxy) pectins are defined as having a degree of esterification of less than 50%.
  • the-OCH 3 group is substituted with a-NH 2 group.
  • Pectins are especially sold by the company Cargill under the name Unipectine TM , by the company CP-Kelco under the name Genu, and by Danisco under the name Grinsted Pectin.
  • Carrageenans are anionic polysaccharides constituting the cell walls of various red algae (Rhodophyceae) belonging to the Gigartinacae, Hypneaceae, Furcellariaceae and Polyideaceae families. They are generally obtained by hot aqueous extraction from natural strains of said algae. These linear polymers, formed by disaccharide units, are composed of two D-galactopyranose units linked alternately by ⁇ (1, 3) and ⁇ (1, 4) bonds. They are highly sulfated polysaccharides (20-50%) and the ⁇ -D-galactopyranosyl residues may be in 3, 6-anhydro form.
  • carrageenans which bear one sulfate-ester group
  • iota-carrageenans which bear two sulfate-ester groups
  • lambda-carrageenans which bear three sulfate-ester groups.
  • Carrageenans are composed essentially of potassium, sodium, magnesium, triethanolamine and/or calcium salts of polysaccharide sulfate esters.
  • Carrageenans are sold especially by the company SEPPIC under the name by the company Gelymar under the names and by the company Cargill, under the names Satiagel TM and Satiagum TM , and by the company CP-Kelco under the names and
  • Agars are galactose polysaccharides contained in the cell wall of some of these species of red algae (rhodophyceae) . They are formed from a polymer group whose base backbone is a ⁇ (1, 3) D-galactopyranose and ⁇ (1, 4) L 3-6 anhydrogalactose chain, these units repeating regularly and alternately. The differences within the agar family are due to the presence or absence of solvated methyl or carboxyethyl groups. These hybrid structures are generally present in variable percentage, depending on the species of algae and the harvest season.
  • Agar-agar is a mixture of polysaccharides (agarose and agaropectin) of high molecular mass, between 40 000 and 300 000 g. mol -1 . It is obtained by manufacturing algal extraction liquors, generally by autoclaving, and by treating these liquors which comprise about 2%of agar-agar, so as to extract the latter.
  • Agar is produced, for example, by the group B&V Agar Producers under the names Gold Agar, Agarite and Grand Agar by the company Hispanagar, and under the names Agar-Agar, QSA (Quick Soluble Agar) , and Puragar by the company Setexam.
  • Gellan gum is an anionic linear heteropolyoside based on oligoside units composed of 4 saccharides (tetra-oside) .
  • D-Glucose, L-rhamnose and D-glucuronic acid in 2: 1: 1 proportions are present in gellan gum in the form of monomer elements.
  • Kelcogel CG LA It is sold, for example, under the name Kelcogel CG LA by the company CP Kelco.
  • the gelatinizing agent is preferably chosen from alkali metal alginic compounds.
  • the particularly preferable gelatinizing agent is alginate, e.g., sodium or potassium alginate, especially sodium alginate.
  • the at least one water soluble gelatinizing agent is present in the third composition from 0.1%to 0.5%by weight, preferably from 0.1%to 0.3%by weight, relative to the total weight of the third composition.
  • the amounts of the chelating agent and the gelatinizing agent are so selected that the molar ratio of the moiety to be released from the chelating agent chelatable with the polyvalent cation to the moiety to be released from the gelatinizing agent gelatinizable with the polyvalent cation ranging from about 10: 1 to about 1: 1, preferably from about 5: 1 to about 2: 1.
  • alkali metal alginic compound in particular means alkali metal alginic acid salts (alginates) or alkali metal salts of alginic acid derivatives.
  • the alkali metal alginic compound is water-soluble.
  • Alginic acid a natural substance obtained from brown algae or from certain bacteria, is a polyuronic acid composed of two uronic acids linked together via 1, 4-glycoside bonds: ⁇ -D-mannuronic acid (M) and ⁇ -L-glucuronic acid (G) .
  • Alginic acid is capable of forming water-soluble salts (alginates) with alkali metals such as sodium, potassium or lithium. These alginates are water-soluble in aqueous medium at pH 4 but dissociate into alginic acid at a pH below 4.
  • Alginic acid or alginates may be chemically modified, especially with urea or urethane groups or by hydrolysis, oxidation, esterification, etherification, sulfatation, phosphatation, amination, amidation or alkylation reaction, or by several of these modifications, forming alginic acid derivatives, including salts.
  • These derivatives may be anionic, cationic, amphoteric or nonionic, and are capable of forming water-soluble salts with an alkali metal such as sodium, potassium or lithium, forming alkali metal salts of alginic acid derivatives.
  • alginates may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form polyglycol alginates.
  • the polyglycol segment is bonded to alginates through the carboxyl group (s) .
  • alginates react with propylene oxide to form polypropylene glycol alginates (PPG alginates)
  • PPG alginates polypropylene glycol alginates
  • PEG alginates polyethylene glycol alginates
  • Preparation of polyglycol alginates is disclosed in Strong, U.S. Pat. No. 3,948,881, Pettitt, U.S. Pat. No. 3,772,266, and Steiner, U.S. Pat. No. 2,426,125.
  • the polyglycol alginate has a degree of esterification of about 40%to about 95%, more preferably about 70%to 95%.
  • Suitable alginates have a weight-average molecular weight of about 20,000 Daltons to about 500,000 Daltons.
  • the weight-average molecular weight is calculated by first determining the intrinsic viscosity, then using the Mark-Houwink Sakurada Equation, as in Martinsen, et al, "Comparison of Different Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (Carbohydr. Polym., 15, 171-193, 1991) .
  • weight-average molecular weights indicated above are also valid for the alkali metal salts of alginic acid derivatives.
  • the alkali metal alginic compound may be chosen from sodium alginate and potassium alginate, preferably sodium alginate.
  • alkali metal alginic compounds that are suitable for use in the present invention may be represented, for example, by the products sold under the names Kelcosol, Satialgine TM , Cecalgum TM or Algogel TM by the company Cargill Products, under the name Protanal TM by the company FMC Biopolymer, under the name Alginate by the company Danisco, under the name Kimica Algin by the company Kimica, and under the names and by the company ISP.
  • the third composition according to the present invention comprises at least one aqueous phase.
  • the at least one aqueous phase comprises water.
  • the aqueous phase may also comprise water-miscible organic solvents (at room temperature: 25°C) , for instance monoalcohols containing from 2 to 6 carbon atoms, such as ethanol or isopropanol; polyols especially containing from 2 to 20 carbon atoms, preferably containing from 2 to 10 carbon atoms and preferentially containing from 2 to 6 carbon atoms, such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol or diethylene glycol; glycol ethers (especially containing from 3 to 16 carbon atoms) such as mono-, di-or tripropylene glycol (C 1 -C 4 ) alkyl ethers, mono-, di-or triethylene glycol (C 1 -C 4 ) alkyl ethers, and mixtures thereof.
  • monoalcohols containing from 2 to 6 carbon atoms, such as ethanol or isoprop
  • the aqueous phase may also comprise any water-soluble or water-dispersible compound that is compatible with an aqueous phase, such as hydrophilic gelling agents, preservatives or surfactants, and mixtures thereof.
  • the third composition of the present invention may comprise the at least one aqueous phase in a content ranging from 10%to 99%by weight, especially from 50%to 99%by weight, and more particularly from 70%to 99%by weight, relative to the total weight of the third composition.
  • the third composition according to the present invention may comprise optionally at least one additional hydrophilic gelling agent.
  • hydrophilic gelling agent means a compound that is capable of gelling the aqueous phase, without combining with the polyvalent metal ions from the first composition.
  • the gelling agent may be water-soluble or water-dispersible.
  • hydrophilic gelling agent may be chosen from synthetic polymeric gelling agents, polymeric gelling agents that are natural or of natural origin, or a mixture thereof.
  • the term "synthetic" means that the polymer is neither naturally existing nor a derivative of a polymer of natural origin.
  • the synthetic polymeric gelling agent under consideration according to the present invention may or may not be particulate.
  • the term "particulate" when being used for the synthetic polymeric gelling agent, means that the polymer is in the form of particles, preferably spherical particles.
  • these polymers may be chosen especially from:
  • modified or unmodified carboxyvinyl polymers such as the products sold under the name (CTFA name: Carbomer) by the company Goodrich; polyacrylates, polymethacrylates such as the products sold under the names Lubrajel TM and Norgel by the company Guardian or under the name by the company Hispano Chimica; polyacrylamides; optionally crosslinked and/or neutralized 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, for instance the poly (2-acrylamido-2-methylpropanesulfonic acid) sold by the company Clariant under the name Hostacerin (CTFA name: ammonium polyacryldimethyltauramide) ; crosslinked anionic copolymers of acrylamide and of which are in the form of a W/O emulsion, such as those sold under the name Sepigel TM 305 (CTFA name: Polyacrylamide/C 13-14 isoparaffin/Laureth-7) and under the name Simulgel TM 600 (CTFA name: Acryl
  • these polymers may be chosen from Acrylates/C 10-30 Alkyl Acrylate Crosspolymer such as, ultrez 20, ultrez 21, Permulen TM TR-1, Permulen TM TR-2, 1382, ETD 2020, Carbomer such as K, 980, Ammonium acryloyldimethyl Taurate/Steareth-8 Methacrylate copolymer such as SNC, Acrylates copolymer such as Aqua SF-1, Ammonium acryloyldimethyl taurate/steareth-25 Methacrylate Crosspolymer such as HMS, Ammonium acryloyldimethyl taurate such as AVC.
  • Acrylates/C 10-30 Alkyl Acrylate Crosspolymer such as, ultrez 20, ultrez 21, Permulen TM TR-1, Permulen TM TR-2, 1382, ETD 2020, Carbomer such as K, 980, Ammonium acryloyldimethyl Taurate/Steareth-8 Methacrylate cop
  • these polymers may be chosen from carboxyvinyl polymers such as the products (carbomers) such as Ultrez 20 Polymer marketed by Lubrizol and the Pemulen products (acrylate/C 10-30 alkylacrylate copolymer) ; polyacrylamides, for instance the crosslinked copolymers marketed under the trademarks Sepigel TM 305 (CTFA name: polyacrylamide/C 13-14 isoparaffin/Laureth-7) or Simulgel TM 600 (CTFA name: acrylamide/sodium acryloyldimethyltaurate copolymer/isohexadecane/polysorbate 80) by SEPPIC; 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, which are optionally crosslinked and/or neutralized, for instance the poly (2-acrylamido-2-methylpropanesulfonic acid) marketed by Hoechst under the trademark Hostacerin (CTFA name: ammonium polyacryloyldi
  • these polymers may be chosen from glyceryl acrylate/acrylic acid copolymers available from ISP Technologies, Inc. (United Guardian Inc. ) under the tradename Lubrajel TM , particular the form known as Lubrajel TM oil which contains about 1.0%-1.3%glyceryl acrylate/acrylic acid copolymer in aqueous glycerin (about 40%glycerin) .
  • Lubrajel TM oil also includes about 0.6%PVM/MA copolymer (also known as methoxyethylene/maleic anhydride copolymer) .
  • the term "of natural origin” is intended to denote polymeric gelling agents obtained by modification of natural polymeric gelling agents.
  • These gelling agents may be particulate or non-particulate.
  • these gelling agents fall within the category of polysaccharides.
  • polysaccharides that are suitable for use in the present invention may be homopolysaccharides such as fructans, glucans, galactans and mannans or heteropolysaccharides such as hemicellulose.
  • they may be linear polysaccharides such as pullulan or branched polysaccharides such as gum arabic and amylopectin, or mixed polysaccharides such as starch.
  • the polysaccharides may be chosen from ones produced by microorganisms; polysaccharides isolated from algae, and higher plant polysaccharides, such as homogeneous polysaccharides, in particular celluloses and derivatives thereof or fructosans, heterogeneous polysaccharides such as gum arables, galactomannans, glucomannans, and derivatives thereof; and mixtures thereof.
  • the polysaccharides may be chosen from fructans, gellans, glucans, amylose, amylopectin, glycogen, pullulan, dextrans, celluloses and derivatives thereof, in particular methylcelluloses, hydroxyalkylcelluloses, ethylhydroxyethylcelluloses and carboxymethylcelluloses, mannans, xylans, lignins, arabans, galactans, galacturonans, chitin, chitosans, glucuronoxylans, arabinoxylans, xyloglucans, glucomannans, arabinogalactans, glycosaminoglucans, gum arables, tragacanth gums, ghatti gums, locust bean gums, galactomannans such as guar gums and nonionic derivatives thereof, in particular hydroxypropyl guar, and ionic derivatives thereof, biopoly saccharide gums of microbial origin, in particular
  • polysaccharides may be chemically modified, especially with urea or urethane groups or by hydrolysis, oxidation, esterification, etherification, sulfatation, phosphatation, amination, amidation or alkylation reaction, or by several of these modifications.
  • the derivatives obtained may be anionic, cationic, amphoteric or nonionic.
  • the polysaccharides may be chosen from xanthan gum, scleroglucan gum, guar gum, inulin and pullulan, and mixtures thereof.
  • the compounds of this type that may be used in the present invention are chosen from those described especially in Kirk-Othmer's Encyclopedia of Chemical Technology, Third Edition, 1982, volume 3, pp. 896-900, and volume 15, pp. 439-458, in Polymers in Nature by E.A. MacGregor and C.T. Greenwood, published by John Wiley&Sons, Chapter 6, pp. 240-328, 1980, in the book by Robert L. Davidson entitled Handbook of Water-Soluble Gums and Resins published by McGraw Hill Book Company (1980) and in Industrial Gums-Polysaccharides and their Derivatives, edited by Roy L. Whistler, Second Edition, published by Academic Press Inc.
  • these polysaccharides that are suitable for use in the present invention may be distinguished according to whether they are derived from microorganisms, from algae or from higher plants, and are detailed below.
  • Xanthan is a heteropolysaccharide produced at the industrial scale by the aerobic fermentation of the bacterium Xanthomonas campestris. Its structure consists of a main chain of ⁇ (1, 4) -linked ⁇ -D-glucoses, similar to cellulose. One glucose molecule in two bears a trisaccharide side chain composed of an ⁇ -D-mannose, a ⁇ -D-glucuronic acid and a terminal ⁇ -D-mannose. The internal mannose residue is generally acetylated on carbon 6. About 30%of the terminal mannose residues bear a pyruvate group linked in chelated form between carbons 4 and 6.
  • the charged pyruvic acids and glucuronic acids are ionizable, and are thus responsible for the anionic nature of xanthan (negative charge down to a pH equal to 1) .
  • the content of pyruvate and acetate residues varies according to the bacterial strain, the fermentation process, the conditions after fermentation and the purification steps. These groups may be neutralized in commercial products with Na + , K + or Ca 2+ ions (Satia company, 1986) .
  • the neutralized form may be converted into the acid form by ion exchange or by dialysis of an acidic solution.
  • Xanthan gums have a molecular weight of between 1 000 000 and 50 000 000 and a viscosity of between 0.6 and 1.65 Pa. s for an aqueous composition containing 1%of xanthan gum (measured at 25°C on a Brookfield viscometer of LVT type at 60 rpm) .
  • Xanthan gums are represented, for example, by the products sold under the names Rhodicare by the company Rhodia Chimie, under the name Satiaxane TM by the company Cargill Texturizing Solutions (for the food, cosmetic and pharmaceutical industries) , under the name Novaxan TM by the company ADM, and under the names and by the company CP-Kelco.
  • Pullulan is a polysaccharide consisting of maltotriose units, known under the name ⁇ (1, 4) - ⁇ (1, 6) -glucan. Three glucose units in maltotriose are connected via an ⁇ (1, 4) glycoside bond, whereas the consecutive maltotriose units are connected to each other via an ⁇ (1, 6) glycoside bond.
  • Pullulan is produced, for example, under the reference Pullulan PF 20 by the group Hayashibara in Japan.
  • Dextran is a neutral polysaccharide not bearing any charged groups, which is biologically inert, prepared by fermentation of beet sugar containing solely hydroxyl groups. It is possible to obtain dextran fractions of different molecular weights from native dextran by hydrolysis and purification. Dextran may in particular be in the form of dextran sulfate.
  • Dextran is represented, for example, by the products sold under the name Dextran or Dextran T by the company Pharmacosmos, or under the name Dextran 40 Powder or Dextran 70 Powder by the company Meito Sangyo Co.
  • Dextran sulfate is sold by the company PK Chemical A/S under the name Dextran sulfate.
  • Succinoglycan is an extracellular polymer of high molecular weight produced by bacterial fermentation, consisting of octasaccharide repeating units (repetition of 8 sugars) .
  • Succinoglycans are sold, for example, under the name Rheozan by the company Rhodia. Scleroglucan
  • Scleroglucan is a nonionic branched homopolysaccharide consisting of ⁇ -D-glucan units.
  • the molecules consist of a linear main chain formed from D-glucose units linked via ⁇ (1, 3) bonds and of which one in three is linked to a side D-glucose unit via a ⁇ (1, 6) bond.
  • Scleroglucan is sold, for example, under the name Amigel by the company Alban Miiller, or under the name Actigum TM CS by the company Cargill.
  • Furcellaran is obtained commercially from red algae Furcellaria fasztigiata. Furcellaran is produced, for example, by the company Est-Agar.
  • This category of polysaccharides may be divided into homogeneous polysaccharides (only one saccharide species) and heterogeneous polysaccharides composed of several types of saccharides.
  • the polysaccharide according to the present invention may be chosen from celluloses and derivatives or fructosans.
  • the polysaccharide according to the present invention may also be a cellulose or a derivative thereof, especially cellulose ethers or esters (e.g. methylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxymethylpropylcellulose, cellulose acetate, cellulose nitrate, nitrocellulose) .
  • cellulose ethers or esters e.g. methylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxymethylpropylcellulose, cellulose acetate, cellulose nitrate, nitrocellulose
  • the present invention may also contain a cellulose-based associative polymer.
  • the repeating unit is the cellobiose dimer.
  • the AGUs are in chair conformation and bear 3 hydroxyl functions: 2 secondary alcohols (in position 2 and 3) and a primary alcohol (in position 6) .
  • the polymers thus formed combine together via intermolecular bonds of hydrogen bond type, thus giving the cellulose a fibrillar structure (about 1500 molecules per fibre) .
  • the degree of polymerization differs enormously depending on the origin of the cellulose; its value may range from a few hundred to several tens of thousands.
  • the hydroxyl groups of cellulose may react partially or totally with various chemical reagents to give cellulose derivatives having intrinsic properties.
  • the cellulose derivatives may be anionic, cationic, amphoteric or nonionic.
  • cellulose ethers, cellulose esters and cellulose ester ethers are distinguished.
  • nonionic cellulose ethers mention may be made of alkylcelluloses such as methylcelluloses and ethylcelluloses; hydroxyalkylcelluloses such as hydroxymethylcelluloses, hydroxyethylcelluloses and hydroxypropylcelluloses; and mixed hydroxyalkylalkylcelluloses such as hydroxypropylmethylcelluloses, hydroxy-ethylmethylcelluloses, hydroxy ethylethylcelluloses and hydroxybutylmethylcelluloses.
  • alkylcelluloses such as methylcelluloses and ethylcelluloses
  • hydroxyalkylcelluloses such as hydroxymethylcelluloses, hydroxyethylcelluloses and hydroxypropylcelluloses
  • mixed hydroxyalkylalkylcelluloses such as hydroxypropylmethylcelluloses, hydroxy-ethylmethylcelluloses, hydroxy ethylethylcelluloses and hydroxybutylmethylcelluloses.
  • anionic cellulose ethers mention may be made of carboxyalkylcelluloses and salts thereof.
  • cationic cellulose ethers mention may be made of crosslinked or non-crosslinked, quaternized hydroxyethylcelluloses.
  • the quaternizing agent may in particular be glycidyltrimethylammonium chloride or a fatty amine such as laurylamine or stearylamine.
  • a fatty amine such as laurylamine or stearylamine.
  • Another cationic cellulose ether that may be mentioned is hydroxy ethylcellulosehydroxypropyltrimethylammonium.
  • the quaternized cellulose derivatives are, in particular:
  • - quaternized celluloses modified with groups comprising at least one fatty chain, such as alkyl, arylalkyl or alkylaryl groups comprising at least 8 carbon atoms, or mixtures thereof,
  • - quaternized hydroxyethylcelluloses modified with groups comprising at least one fatty chain, such as alkyl, arylalkyl or alkylaryl groups comprising at least 8 carbon atoms, or mixtures thereof.
  • the alkyl radicals borne by the above quaternized celluloses or hydroxyethylcelluloses preferably contain from 8 to 30 carbon atoms.
  • the aryl radicals preferably denote phenyl, benzyl, naphthyl or anthryl groups.
  • Examples of quaternized alkylhydroxyethylcelluloses containing C 8-30 fatty chains that may be indicated include the products Quatrisoft LM 200, Quatrisoft LM-X 529-18-A, Quatrisoft LM-X 529-18B (C 12 alkyl) and Quatrisoft LM-X 529-8 (C 18 alkyl) sold by the company Amerchol and the products Crodacel QM, Crodacel QL (C 12 alkyl) and Crodacel QS (C 18 alkyl) sold by the company Croda.
  • - celluloses modified with groups comprising at least one fatty chain for instance hydroxyethylcelluloses modified with groups comprising at least one fatty chain, such as alkyl groups, especially of C 8-22 , arylalkyl and alkylaryl groups, such as Natrosol Plus Grade 330 CS (C 16 alkyls) sold by the company Aqualon, and
  • polyalkylene glycol alkylphenyl ether groups such as the product Amercell Polymer HM-1500 (nonylphenyl polyethylene glycol (15) ether) sold by the company Amerchol.
  • cellulose esters are mineral esters of cellulose (cellulose nitrates, sulfates, phosphates, etc. ) , organic cellulose esters (cellulose monoacetates, triacetates, amidopropionates, acetatebutyrates, acetatepropionates and acetatetrimellitates, etc. ) , and mixed organic/mineral esters of cellulose, such as cellulose acetatebutyrate sulfates and cellulose acetatepropionate sulfates.
  • cellulose ester ethers mention may be made of hydroxypropylmethylcellulose phthalates and ethylcellulose sulfates.
  • the cellulose-based compounds of the present invention may be chosen from unsubstituted celluloses and substituted celluloses.
  • the celluloses and derivatives are represented, for example, by the products sold under the names (microcrystalline cellulose, MCC) by the company FMC Biopolymers, under the name Cekol (carboxymethylcellulose) by the company Noviant (CP-Kelco) , under the name Akucell AF (sodium carboxymethylcellulose) by the company Akzo Nobel, under the name Methocel TM (cellulose ethers) and Ethocel TM (ethylcellulose) by the company Dow, and under the names (carboxymethylcellulose and sodium carboxymethylcellulose) , (methylcellulose) , Blanose TM (carboxymethylcellulose) , (methylcellulose, hydroxypropylmethylcellulose) , (hydroxypropylcellulose) , (cetylhydroxyethylcellulose) and CS (hydroxy ethylcellulose) by the company Hercules Aqualon.
  • the polysaccharide according to the present invention may especially be a fructosan chosen from inulin and derivatives thereof (especially dicarboxy and carboxymethyl inulins) .
  • Fructans or fructosans are oligosaccharides or polysaccharides comprising a sequence of anhydrofructose units optionally combined with several saccharide residues other than fructose.
  • Fructans may be linear or branched.
  • Fructans may be products obtained directly from a plant or microbial source or alternatively products whose chain length has been modified (increased or decreased) by fractionation, synthesis or hydrolysis, in particular enzymatic.
  • Fructans generally have a degree of polymerization from 2 to about 1000 and preferably from 2 to about 60.
  • the first group corresponds to products whose fructose units are for the most part linked via ⁇ (2, 1) bonds. These are essentially linear fructans such as inulins.
  • the second group also corresponds to linear fructoses, but the fructose units are essentially linked via ⁇ (2, 6) bonds. These products are levans.
  • the third group corresponds to mixed fructans, i.e. containing ⁇ (2, 6) and ⁇ (2, 1) sequences. These are essentially branched fructans, such as graminans.
  • the preferred fructans in the compositions according to the present invention are inulins.
  • Inulin may be obtained, for example, from chicory, dahlia or Jerusalem artichoke, preferably from chicory.
  • the polysaccharide especially the inulin, has a degree of polymerization from 2 to about 1000 and preferably from 2 to about 60, and a degree of substitution of less than 2 on the basis of one fructose unit.
  • the inulin used for the present invention is represented, for example, by the products sold under the name Beneo TM inulin by the company Orafti, and under the name by the company Sensus.
  • the polysaccharides that may be used according to the present invention may be gums, for instance cassia gum, karaya gum, konjac gum, gum tragacanth, tara gum, acacia gum or gum arabic.
  • Gum arabic is a highly branched acidic polysaccharide which is in the form of mixtures of potassium, magnesium and calcium salts.
  • the monomer elements of the free acid (arabic acid) are D-galactose, L-arabinose, L-rhamnose and D-glucuronic acid.
  • Galactomannans guar, locust bean, fenugreek, tara gum
  • derivatives guar phosphate, hydroxypropyl guar, etc.
  • Galactomannans are nonionic polyosides extracted from the endosperm of leguminous seeds, of which they constitute the storage carbohydrate.
  • Galactomannans are macromolecules consisting of a main chain of ⁇ (1, 4) -linked D-mannopyranose units, bearing side branches consisting of a single D-galactopyranose unit ⁇ (1, 6) -linked to the main chain.
  • the various galactomannans differ, firstly, by the proportion of ⁇ -D-galactopyranose units present in the polymer, and secondly, by significant differences in terms of distribution of galactose units along the mannose chain.
  • the mannose/galactose (M/G) ratio is about 2 for guar gum, 3 for tara gum and 4 for locust bean gum.
  • Guar gum is characterized by a mannose/galactose ratio of the order of 2/1.
  • the galactose group is regularly distributed along the mannose chain.
  • guar gums that may be used according to the present invention may be nonionic, cationic or anionic. According to the present invention, use may be made of chemically modified or unmodified nonionic guar gums.
  • the unmodified nonionic guar gums are, for example, the products sold under the names Vidogum GH, Vidogum G and Vidocrem by the company Unipektin and under the name Jaguar by the company Rhodia, under the name Guar by the company Danisco, under the name Viscogum TM by the company Cargill, and under the name guar gum by the company Aqualon.
  • hydrolysed nonionic guar gums that may be used according to the present invention are represented, for example, by the products sold under the name by the company Danisco.
  • modified nonionic guar gums that may be used according to the present invention are preferably modified with C 1-6 hydroxyalkyl groups, among which mention may be made, for example, of hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups.
  • nonionic guar gums optionally modified with hydroxyalkyl groups are sold, for example, under the trade names Jaguar HP 60, Jaguar HP 105 and Jaguar HP 120 (hydroxypropyl guar) by the company Rhodia or under the name HP (hydroxypropyl guar) by the company Aqualon.
  • the cationic galactomannan gums preferably have a cationic charge density of less than or equal to 1.5 meq. /g, more particularly between 0.1 and 1 meq. /g.
  • the charge density may be determined by the Kjeldahl method. It generally corresponds to a pH of the order of 3 to 9.
  • cationic galactomannan gum means any galactomannan gum containing cationic groups and/or groups that can be ionized into cationic groups.
  • the preferred cationic groups are chosen from those comprising primary, secondary, tertiary and/or quaternary amine groups.
  • the cationic galactomannan gums used generally have a weight-average molecular mass of between 500 and 5 ⁇ 10 6 approximately and preferably between 10 3 and 3 ⁇ 10 6 approximately.
  • the cationic galactomannan gums that may be used according to the present invention are, for example, gums comprising tri (C 1-4 ) alkylammonium cationic groups. Preferably, 2%to 30%by number of the hydroxyl functions of these gums bear trialkylammonium cationic groups.
  • trialkylammonium groups mention may be made most particularly of trimethylammonium and triethylammonium groups.
  • these groups represent from 5%to 20%by weight relative to the total weight of the modified galactomannan gum.
  • the cationic galactomannan gum is preferably a guar gum comprising hydroxypropyltrimethylammonium groups, i.e. a guar gum modified, for example, with 2, 3-epoxypropyltrimethylammonium chloride.
  • galactomannan gums in particular guar gums modified with cationic groups are products already known per se and are, for example, described in patents US 3 589 578 and US 4 031 307.
  • Such products are moreover sold especially under the trade names Jaguar EXCEL, Jaguar C13 S, Jaguar C 15, Jaguar C 17 and Jaguar CI 62 (Guar Hydroxypropyltrimonium Chloride) by the company Rhodia, under the name Guar (Guar Hydroxypropyltrimonium Chloride) by the company Degussa, and under the name 3000 (Guar Hydroxypropyltrimonium Chloride) by the company Aqualon.
  • the anionic guar gums that may be used according to the present invention are polymers comprising groups derived from carboxylic, sulfonic, sulfenic, phosphoric, phosphonic or pyruvic acid.
  • the anionic group is preferably a carboxylic acid group.
  • the anionic group may also be in the form of an acid salt, especially a sodium, calcium, lithium or potassium salt.
  • anionic guar gums that may be used according to the present invention are preferentially carboxymethyl guar derivatives (carboxymethyl guar or carboxymethyl hydroxypropyl guar) .
  • Locust bean gum is extracted from the seeds of the locust bean tree Ceratonia siliqua) .
  • the unmodified locust bean gum that may be used in the present invention is sold, for example, under the name Viscogum TM by the company Cargill, under the name Vidogum L by the company Unipektin and under the name LBG by the company Danisco.
  • the chemically modified locust bean gums that may be used in the present invention may be represented, for example, by the cationic locust beans sold under the name Catinal CLB (locust bean hydroxypropyltrimonium chloride) by the company Toho.
  • Catinal CLB locust bean hydroxypropyltrimonium chloride
  • the tara gum that may be used in the context of the present invention is sold, for example, under the name Vidogum SP by the company Unipektin.
  • Glucomannan is a polysaccharide of high molecular weight (500 000 ⁇ Mglucomannan ⁇ 2 000 000) composed of D-mannose and D-glucose units with a branch every 50 or 60 units approximately. It is found in wood, but is also the main constituent of konjac gum. Konjac (Amorphophallus konjac) is a plant of the Araceae family.
  • chitin poly-N-acetyl-D-glucosamine, ⁇ (1, 4) -2-acetamido-2-deoxy-D-glucose
  • chitosan and derivatives chitosan- ⁇ -glycerophosphate, carboxymethylchitin, etc.
  • glycosaminoglycans such as hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, and preferably hyaluronic acid
  • xylans or arabinoxylans
  • Arabinoxylans are polymers of xylose and arabinose, all grouped under the name pentosans.
  • Xylans consist of a main chain of ⁇ (1, 4) -linked D-xylose units and on which are found three substituents (Rouau & Thibault, 1987) : acid units, ⁇ -L-arabinofuranose units, side chains which may contain arabinose, xylose, galactose and glucuronic acid.
  • the polysaccharide is preferably hyaluronic acid, or a salt thereof.
  • the at least one hydrophilic gelling agent may be present in an amount ranging for example from 0.001 to 10%by weight, preferably 0.01 to 5%by weight and more preferably from 0.05 to 3%by weight relative to the total weight of the third composition.
  • the first composition may comprise at least one additional active agent.
  • the second composition may comprise at least one additional active agent.
  • the third composition may comprise at least one additional active agent.
  • the first composition includes the at least one active agent
  • it may be incorporated into the first composition in particular by means of an alternating electric field.
  • the active agent (s) may be incorporated in particular in the powder state.
  • ⁇ -or ⁇ -hydroxy acids such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicyclic acid, ⁇ -hydroxydecanoic acid, ⁇ -hydroxylauric, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, ⁇ -hydroxybutyric acid, ⁇ -hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid, and salicylic acid.
  • ⁇ -or ⁇ -hydroxy acids such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicyclic acid, ⁇ -hydroxydecanoic acid, ⁇ -hydroxylauric, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, ⁇ -hydroxybutyric acid, ⁇ -hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid, and salicylic
  • anti-acne agents such as salicylic acid or benzoyl peroxide, octopirox, dextrorotary and levorotary sulfur-containing amino acids, their salts, and their N-acetyl derivatives such as N-acetyl cysteine, or agents seeking to prevent aging of the skin and/or to improve its state, for example the above-mentioned ⁇ -and ⁇ -hydroxy acids, retinoids such as retinoic acid, retinol, and its esters, such as, for example, retinyl propionate, and retinyl acetate, or retinyl palmitate, niacinamide, allantoin, extracts of aloe, azelaic acid, bisabolol, phytic acid, collagen, or agents stimulating the formation of collagen, vitamins such as vitamin C or derivatives thereof, such as ascorbyl glucoside, vitamin E or derivatives thereof, vitamin A or derivatives thereof, vitamin
  • active agents for improving the condition of the skin in the case of mask, such as moisturizers or agents serving to improve the natural lipid barrier, such as ceramides, cholesterol sulfates, and/or fatty acids, and mixtures thereof.
  • active agents for improving the condition of the skin such as moisturizers or agents serving to improve the natural lipid barrier, such as ceramides, cholesterol sulfates, and/or fatty acids, and mixtures thereof.
  • enzymes that have activity on the skin such as proteases, lipases, cerebrosidases, and/or melanases, and mixtures thereof.
  • active agents there are agents for drugs, peptides, proteins, detectable labels, contrast reagents, pain-killing, anesthetics, antibacterial agents, anti-yeast agents, antifungal agents, antiviral agents, anti-dermititis agents, anti-pruritic agents, anti-emetics, vascular protectors, agents against motion sickness, anti-irritants, anti-inflammatory agents, immunomodulators, anti-hyperkeratolytic agents, agents for treating dry skin, antiperspirants, anti-psoriatic agents, antidandruff agents, anti-aging agents, anti-asthmatic agents and bronchodilators, sunscreen agents, antihistamines, healing agents, corticosteroids, tanning agents, and mixtures thereof.
  • the content of the at least one active agent in the first composition and/or in the third composition may be adjusted as a function of the intended purpose of the kit.
  • Hyaluronic compound may be also used as an active agent according to the present invention.
  • the hyaluronic compound is preferably an alkali metal hyaluronic compound.
  • alkali metal hyaluronic compound in particular means alkali metal salts of hyaluronic acid (hyaluronates) or derivatives thereof.
  • the alkali metal hyaluronic compound is water-soluble.
  • hyaluronic acid or derivatives thereof covers in particular the basic unit of hyaluronic acid of formula:
  • hyaluronic acid comprising a disaccharide dimer, namely D-glucuronic acid and N-acetylglucosamine.
  • hyaluronic acid or derivatives thereof also comprises, in the context of the present invention, the linear polymer comprising the polymeric unit described above, linked together in the chain via alternating ⁇ (1, 4) and ⁇ (1, 3) glycosidic linkages, having a molecular weight (Mw) that can range between 380 and 13 000 000 daltons. This molecular weight depends in large part on the source from which the hyaluronic acid is obtained and/or on the preparation methods.
  • Mw molecular weight
  • hyaluronic acid is present in pericellular gels, in the base substance of the connective tissues of vertebrate organs such as the dermis and epithelial tissues, and in particular in the epidermis, in the synovial fluid of the joints, in the vitreous humor, in the human umbilical cord and in the crista galli apophysis.
  • hyaluronic acid or derivatives thereof comprises all the fractions or subunits of hyaluronic acid having a molecular weight in particular within the molecular weight range recalled above.
  • the hyaluronic acid fractions suitable for the use covered by the present invention have a molecular weight of between 50 000 and 5 000 000, in particular between 100 000 and 5 000 000, especially between 400 000 and 5 000 000 Da.
  • the term used is high-molecular-weight hyaluronic acid.
  • the hyaluronic acid fractions that may also be suitable for the use covered by the present invention have a molecular weight of between 50 000 and 400 000 Da.
  • the term used is intermediate-molecular-weight hyaluronic acid.
  • the hyaluronic acid fractions that may be suitable for the use covered by the present invention have a molecular weight of less than 50 000 Da.
  • the term used is low-molecular-weight hyaluronic acid.
  • hyaluronic acid or derivatives thereof also comprises hyaluronic acid esters in particular those in which all or some of the carboxylic groups of the acid functions are esterified with oxyethylenated alkyls or alcohols, containing from 1 to 20 carbon atoms, in particular with a degree of substitution at the level of the D-glucuronic acid of the hyaluronic acid ranging from 0.5 to 50%.
  • hyaluronic acid or hyaluronates may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form polyglycol hyaluronates.
  • alkylene oxide such as ethylene oxide or propylene oxide
  • the polyglycol segment is bonded to hyaluronic acid through the carboxyl group (s) .
  • hyaluronic acid or hyaluronates react with propylene oxide to form polypropylene glycol hyaluronates, while react with ethylene oxide to form polyethylene glycol hyaluronates.
  • esters of hyaluronic acid include methyl, ethyl, n-propyl, n-pentyl, benzyl and dodecyl esters of hyaluronic acid. Such esters have in particular been described in D. Campoccia et al. "Semisynthetic resorbable materials from hyaluronan esterification” , Biomaterials 19 (1998) 2101-2127.
  • the third composition of the present invention may also contain adjuvants that are common in cosmetics and/or dermatology, such as preserving agents, antioxidants, pH modifiers (acidic or basic) , fragrances, fillers, bactericides, odour absorbers, colorants (pigments and dyes) , emulsifiers, and also lipid vesicles.
  • adjuvants that are common in cosmetics and/or dermatology, such as preserving agents, antioxidants, pH modifiers (acidic or basic) , fragrances, fillers, bactericides, odour absorbers, colorants (pigments and dyes) , emulsifiers, and also lipid vesicles.
  • the third composition according to the present invention may be in various forms, in particular in the form of aqueous solution, dispersion, or emulsion, especially such as a water/oil or oil/water emulsion or multiple emulsions.
  • An emulsion may have an oily or aqueous continuous phase.
  • Such an emulsion may be, for example, an inverse (W/O) emulsion or a direct (O/W) emulsion, or alternatively a multiple emulsion (W/O/W or O/W/O) .
  • the third composition according to the present invention may be in the form of an oil-in-water (O/W) emulsion, water-in-oil (W/O) emulsion, or a multiple emulsion, preferably a oil-in-water (O/W) emulsion.
  • O/W oil-in-water
  • W/O water-in-oil
  • W/W multiple emulsion
  • the third composition of the present invention is preferably an aqueous solution.
  • kit 2 comprises the first composition comprising a polyvalent metal ion, the second composition and the aqueous third composition.
  • the active agent is kept in dry form, the activity thereof is maintained as high as possible.
  • the first, second and third compositions are separately placed from each other in kit 2.
  • the second composition is added into appropriate amount of the aqueous third composition, for dissolving the active agent.
  • the active agent With the promotion by the disintegrating agent, the active agent is dissolved very rapidly.
  • the solution of the active agent is applied to the water insoluble substrate of the first composition, e.g., through immersing the substrate in the solution, injecting the solution into the substrate, spraying the solution onto the substrate, or the like.
  • the first and second compositions are placed in a same package. Immediately before use, the first and second compositions are together added with the aqueous third composition. Subsequently, gelatinization between the first and third composition, and dissolution of the second composition into the third composition will concurrently occur. Due to the very rapid dissolution speed of the second composition achieved by selecting out the specific disintegrating agent, and optionally the binder, the active agent in the second composition, is quickly dissolved into the aqueous phase quite before the completion of gelatinization, such that active agent from the second composition is homogeneously distributed in the gel finally formed.
  • the kit 2 according to the present invention may comprise 1-10%, preferably 2%-5%by weight of a first composition, 0.5-20%, preferably 1-10%, or 2-5%by weight of a second composition, and 70-98.5%, preferably 75-95%by weight of a third composition, relative to the total weight of the kit 2.
  • the kit 2 presents as a mask comprising:
  • a first composition consisting of a nonwoven fabric (or tissue) comprising from 10%to 100%by weight, preferably from 15%to 50%by weight, of calcium alginate fiber, relative to the total weight of the nonwoven fabric,
  • a second composition comprising dry particles of from 20%to 99.9%by weight, preferably from 40%to 95%by weight, especially from 50%to 90%by weight of at least one water soluble active agent, and 0.1%to 20%by weight, preferably from 0.2%to 15%by weight, especially from 0.5%to 10%by weight, by weight of at least one disintegrating agent, relative to the total weight of the second composition,
  • a third composition comprising from 10%to 99%by weight, preferably from 50%to 99%by weight, of the at least one aqueous phase, from 0.1%to 0.5%by weight, preferably from 0.1%to 0.3%by weight, of sodium alginate, and from 0.1%to 2%by weight, preferably from 0.2%to 1%by weight, of sodium citrate, relative to the total weight of the third composition,
  • the mask comprises 1-10%, preferably 2-5%by weight of the first composition, 0.5-20%, preferably 1-10%, or 2-5%by weight of the second composition, and 70-98.5%, preferably 75-95%by weight of the third composition, relative to the total weight of the mask.
  • the first composition, the second composition and the third composition according to the present invention can be generally prepared according to the general knowledge of a person skilled in the art. Nevertheless, it is to be understood that a person skilled in the art can choose its method of preparation, on the basis of his/her general knowledge, taking into account the nature of the constituents used, for example, their solubility in the vehicle, and the application envisaged for the compositions or the kit.
  • the kit 1 and/or 2 according to the present invention can be used for conditioning keratin materials, especially the face.
  • This use may manifest itself as a process for conditioning keratin materials, especially the face, comprising the steps of compounding the first composition and the second composition, and optionally the third composition of the kit at a predetermined weight ratio, and then applying to said keratin materials the thus obtained mixture as a mask.
  • the kit 1 and/or 2 according to the present invention can be used for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, and so on.
  • This use may manifest itself as a process for managing skin wound, for preventing post-surgical adhesion formation, or for filling or repairing osteochondral defects, comprising the steps of compounding the first composition and the third composition of the kit at a predetermined weight ratio, and then applying to a location in need of the thus obtained mixture as a mask or stuffing.
  • compositions/formulas described below are expressed in %by weight, relative to the total weight of each composition/formula.
  • compositions of the present invention were prepared, in which each disintegrating agent served also as a binder.
  • the compositions were provided in Table 1 below:
  • composition (inventive A to D, and comparative F) were prepared according to the process of:
  • step 2 starting the spraying means of the fluidized bed, and spraying the solution of the disintegrating agent obtained from step 2) into the powders of the disintegrating agent along the tangential direction of the plate, so as to bind the powders to form particles;
  • the invention composition E was prepared according to the following process:
  • compositions A to G 0.75g of each of the compositions A to G, respectively, were placed together with a nonwoven fabric with a weight of 1.3g, made of 20%by weight of calcium alginate fiber and 80%of lyocell fiber, sold by the Sanjiang company under the name M762R-40CN, as pack 1, and 33 grams of Composition III was placed separately, as pack 2.
  • the mask products were shown as following:
  • Dissolving speed was measured by mixing the pack 2 with pack 1 (T0) , rubbing the mixture with hand until the second composition dissolved (T1) , and measuring the time duration (T1-T0) .
  • the juice uptake and delivery capacity were measured by weighing the weight of the mask products before, during, and after application on the skin mannequin.
  • Juice it refers to the mixture of the second composition (composition A to G respectively) and the third composition (composition III) .
  • Juice uptake showed the amount of the juice on the tissue after mixing of pack 1 and pack 2; delivery capacity (mg/cm 2 ) showed the amount of the juice on the surface of the skin mannequin.
  • the mask of the present invention is superior in terms of beneficial properties, e.g. easy usage, which is demonstrated by the dissolving speed of the second composition within 180 seconds during application. More surprisingly, inventors found that the present invention is also excellent on absorption of more juice and delivery of more juice to face, which means more active agents such as ascorbic acid can be penetrated to deliver high efficacy, over the comparative one.
  • the invention masks A to E also present unique use experience: texture transformation from tissue to gel. This transformation further enhanced the technical effects of the present invention, such as an even better juice uptake and delivery capacity, and moreover, an excellent skin sensory.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un kit comprend : 1) une première composition comprenant au moins un substrat insoluble dans l'eau; et 2) une seconde composition comprenant un agent actif hydrosoluble et un agent délitant sous forme sèche.
PCT/CN2018/113992 2018-06-28 2018-11-05 Kit de soins de la peau WO2020093206A1 (fr)

Priority Applications (4)

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CN201880100592.0A CN113226248A (zh) 2018-11-05 2018-11-05 用于护理皮肤的套装
PCT/CN2018/113992 WO2020093206A1 (fr) 2018-11-05 2018-11-05 Kit de soins de la peau
PCT/CN2019/078018 WO2020001069A1 (fr) 2018-06-28 2019-03-13 Kit de soins de la peau
CN201980043523.5A CN112334124A (zh) 2018-06-28 2019-03-13 用于护理皮肤的套盒

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111616993A (zh) * 2020-07-17 2020-09-04 华容县新发农业开发有限公司 一种红豆杉面膜及其制备方法和应用
WO2022205059A1 (fr) * 2021-03-31 2022-10-06 L'oreal Compositions pour le soin de la peau et emballage pour les contenir
WO2022226872A1 (fr) * 2021-04-29 2022-11-03 L'oreal Trousse de soin de la peau
FR3134009A1 (fr) * 2022-03-31 2023-10-06 L'oreal Nécessaire pour le soin des matières kératineuses
FR3139006A1 (fr) * 2022-08-31 2024-03-01 L'oreal Composition de soin des matières kératineuses et masque la contenant

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Publication number Priority date Publication date Assignee Title
CN101056605A (zh) * 2004-11-12 2007-10-17 宝洁公司 包含基底和凝胶组合物的美容处理制品
CN101361700A (zh) * 2007-08-08 2009-02-11 秦益民 一种含海藻酸纤维的面膜材料、制备方法和应用
CN104803082A (zh) * 2014-01-24 2015-07-29 李和伟 一种含有冻干赋型制剂的新型面膜包装用三室袋及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101056605A (zh) * 2004-11-12 2007-10-17 宝洁公司 包含基底和凝胶组合物的美容处理制品
CN101361700A (zh) * 2007-08-08 2009-02-11 秦益民 一种含海藻酸纤维的面膜材料、制备方法和应用
CN104803082A (zh) * 2014-01-24 2015-07-29 李和伟 一种含有冻干赋型制剂的新型面膜包装用三室袋及其制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111616993A (zh) * 2020-07-17 2020-09-04 华容县新发农业开发有限公司 一种红豆杉面膜及其制备方法和应用
WO2022205059A1 (fr) * 2021-03-31 2022-10-06 L'oreal Compositions pour le soin de la peau et emballage pour les contenir
WO2022226872A1 (fr) * 2021-04-29 2022-11-03 L'oreal Trousse de soin de la peau
FR3122330A1 (fr) * 2021-04-29 2022-11-04 L'oreal Kit pour le soin de la peau
FR3134009A1 (fr) * 2022-03-31 2023-10-06 L'oreal Nécessaire pour le soin des matières kératineuses
FR3139006A1 (fr) * 2022-08-31 2024-03-01 L'oreal Composition de soin des matières kératineuses et masque la contenant

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