WO2020087765A1 - Pansement antibactérien à action prolongée - Google Patents

Pansement antibactérien à action prolongée Download PDF

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Publication number
WO2020087765A1
WO2020087765A1 PCT/CN2019/000112 CN2019000112W WO2020087765A1 WO 2020087765 A1 WO2020087765 A1 WO 2020087765A1 CN 2019000112 W CN2019000112 W CN 2019000112W WO 2020087765 A1 WO2020087765 A1 WO 2020087765A1
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WO
WIPO (PCT)
Prior art keywords
layer
long
band
aid
sponge layer
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Application number
PCT/CN2019/000112
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English (en)
Chinese (zh)
Inventor
曹华
郭鹏峰
徐晓琳
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广东药科大学
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Filing date
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Application filed by 广东药科大学 filed Critical 广东药科大学
Publication of WO2020087765A1 publication Critical patent/WO2020087765A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines

Definitions

  • the invention belongs to the field of medicine and specifically relates to a long-acting antibacterial band-aid.
  • Band-Aid is a medical product that is often used in people's lives. It is inevitable that some small wounds are prone to appear in daily life. The most commonly used is Band-Aid. However, although ordinary band-aids can block the wound and the external environment, these band-aids do not inhibit bacteria well during use, and the wound tissue is soaked by tissue fluid due to the leakage of wound tissue fluid, which is not conducive to wound healing.
  • Chinese patent application CN106267308A discloses a band-aid.
  • the invention is a band-aid for the treatment of wounds. It includes adhesive tape, cotton fiber or isolation film, and plastic paper is bonded at both ends of the adhesive tape.
  • a non-woven fabric with hemostatic and anti-inflammatory effects containing soybean fiber is laid on the top, which has rapid hemostasis and fast healing on the wound, and has low production cost and more environmentally friendly effect after use.
  • the band-aid does not inhibit bacteria for a long time, so the wound healing effect during use is not ideal.
  • Chinese patent application CN108355001A discloses a band-aid, which includes a bandage, with adhesive layers at both ends of the bandage, a hemostatic antibacterial drug layer in the middle of the band, and a circle in the middle of the band Shaped through hole, elastic tape is arranged in the round through hole of the tape, the edge of the tape is fixed on the tape by pasting or needle thread, the hemostatic antibacterial drug layer is located in the middle of the tape and on the surface of the tape , Wherein the components of the hemostatic antibacterial drug layer are prepared by the following parts by weight of the raw material medicine: 30 parts of Huanghuamin, 25 parts of sage, 18 parts of grass blood, 20 parts of E. adenophora, 15 parts of stalk flower, narrow 10 copies of Ye Penglaige.
  • the structure of the invention is reasonably arranged, which is provided with a circular through hole on the winding belt and a circular through hole
  • the fingertips are extended into the circular through holes, and then the tape is wrapped tightly, which greatly improves its scope of application, and has strong applicability and good practicability.
  • the components used in the drug layer of the band-aid are traditional Chinese medicine components, and their effects are slow, and the band-aid does not inhibit bacteria well, thereby affecting wound healing.
  • the existing band-aid also has some antibacterial and anti-inflammatory effects, its antibacterial effect is poor and the duration is short, and the bandage at the wound becomes moist due to the leakage of tissue fluid at the wound, making it easier Breeds bacteria and is not conducive to wound healing.
  • the object of the present invention is to provide a long-acting antibacterial band-aid.
  • the long-acting antibacterial band-aid provided by the present invention contains a porous drug layer, and the drug combination in the porous drug layer can effectively inhibit the proliferation of bacteria, and can release blood and tissue fluid from the wound into the sponge layer through small holes while releasing the drug It is quickly absorbed, and the sponge layer provided by the present invention can not only quickly absorb blood and tissue fluid at the wound, but also play a certain bacteriostatic effect, can better maintain a sterile environment and promote wound healing.
  • a long-acting antibacterial band-aid including a tape layer, a sponge layer composed of chitosan and cellulose, 6,6'-difluoro-3,3'-biimidazo [1,2-a] pyridine and 5-
  • a porous drug layer composed of hexanoyl-2-methyl-N-o-tolyl-3-carboxamide, the sponge layer is located between the tape layer and the porous drug layer.
  • the area of the sponge layer is 3 / 10-2 / 5 of the area of the tape layer.
  • the preparation method of the sponge layer is: mixing the chitosan solution and the cellulose solution, freeze drying, squeezing, and obtaining a sponge layer.
  • the concentration of the chitosan solution is 1-3 mg / mL, and the concentration of the cellulose solution is 2-4 mg / mL, wherein the volume ratio of the cellulose solution and the chitosan solution is 2 -5: 3-7.
  • the thickness of the sponge layer is 0.1-0.5 mm.
  • the area of the porous drug layer is 1.2-1.5 times the area of the sponge layer.
  • the preparation method of the porous drug layer is: after the non-woven fabric is perforated, soaked in the aqueous solution of the drug composition for 20-40 minutes, and then freeze-dried.
  • the pharmaceutical composition in the porous drug layer consists of 6,6'-difluoro-3,3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N- O-Tolyl-3-carboxamide is composed of 4-7: 1-3 by mass ratio.
  • the pharmaceutical composition in the porous drug layer consists of 6,6'-difluoro-3,3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N -
  • the composition of o-tolyl-3-carboxamide is 5: 2 by mass ratio.
  • the perforation is to uniformly punch 200-300 holes with a diameter of 0.1-0.3 mm on the non-woven fabric.
  • the present invention has the following advantages:
  • the long-acting antibacterial band-aid provided by the present invention contains 6,6'-difluoro-3,3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N- Porous drug layer composed of o-tolyl-3-carboxamide, the drug combination can be long-acting bacteriostatic.
  • the porous drug layer of the long-acting antibacterial band-aid provided by the present invention contains small holes, which can allow blood and tissue fluid at the wound to enter the sponge layer in the middle through the small holes to keep the drug layer dry, and further reduce the growth of bacteria.
  • the sponge layer of the long-acting antibacterial band-aid provided by the present invention is made of chitosan and cellulose.
  • the sponge layer can quickly absorb liquid and has a bacteriostatic effect, so that the sponge layer is not easy to breed bacteria under wet conditions. , So that it has a bacteriostatic effect.
  • the long-acting antibacterial band-aid provided by the present invention prevents the wound from being soaked with tissue fluid for a long time, and can accelerate wound healing.
  • FIG. 1 Schematic diagram of band-aid structure
  • Example 1 A long-acting antibacterial band-aid
  • a long-acting bacteriostatic band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 6, 6'-difluoro-3, 3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide porous drug layer 2, the sponge layer is located on the adhesive tape layer and the porous drug Between layers.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is: dissolving chitosan in an acetic acid solution with a mass percentage of 0.1% to obtain a concentration of 1 mg / mL chitosan solution, and dissolving cellulose in deionized water to obtain a concentration of 2 mg / mL fiber
  • a plain solution the two solutions are mixed at a volume ratio of 2: 3, freeze-dried, and extruded to form a sponge layer with a thickness of 0.1 mm.
  • the preparation method of the porous drug layer is: punching 200 holes with a diameter of 0.1 mm in the thickness of the nonwoven fabric, and then soaking the material room to 6,6'-difluoro-3,3'-biimidazo [1 , 2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide in an aqueous solution of the pharmaceutical composition composed of a mass ratio of 4: 1, soaked for 20 minutes and freeze-dried to obtain a porous drug layer .
  • the non-woven fabric tape on the bottom layer, and put a sponge layer and a porous drug layer respectively to obtain a long-acting antibacterial band-aid.
  • the area of the sponge layer is 3/10 of the area of the tape layer and the area of the porous drug layer is 1.2 times the area of the sponge layer.
  • Example 2 A long-acting antibacterial band-aid
  • a long-acting bacteriostatic band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 6, 6'-difluoro-3, 3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide porous drug layer 2, the sponge layer is located on the adhesive tape layer and the porous drug Between layers.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is: dissolving chitosan in an acetic acid solution with a mass percentage of 0.1% to obtain a concentration of 3mg / mL chitosan solution, and dissolving cellulose in deionized water to obtain a concentration of 4mg / mL fiber
  • a plain solution mix the two solutions in a volume ratio of 5: 7, freeze-dry, and squeeze to form a sponge layer with a thickness of 0.5 mm.
  • the preparation method of the porous drug layer is: punching 300 holes with a diameter of 0.3 mm in the thickness of the nonwoven fabric, and then soaking the material room to 6,6'-difluoro-3,3'-biimidazo [1 , 2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide at a mass ratio of 7: 3 in the aqueous solution of the pharmaceutical composition, soaked for 40 min and freeze-dried to obtain a porous drug layer .
  • the non-woven fabric tape on the bottom layer, and put a sponge layer and a porous drug layer, respectively, to obtain a long-acting antibacterial band-aid.
  • the area of the sponge layer is 2/5 of the area of the tape layer, and the area of the porous drug layer is Said 1.5 times the area of the sponge layer.
  • Example 3 A long-acting antibacterial band-aid
  • a long-acting bacteriostatic band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 6, 6'-difluoro-3, 3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide porous drug layer 2, the sponge layer 3 is located on the tape layer and the Between porous drug layers.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is: dissolving chitosan in an acetic acid solution with a mass percentage of 0.1% to obtain a concentration of 1-3 mg / mL chitosan solution, and dissolving cellulose in deionized water to obtain a concentration of 2- 4mg / mL cellulose solution, mix the two solutions at a volume ratio of 3: 5, freeze-dry, and squeeze to obtain a sponge layer with a thickness of 0.3mm.
  • the preparation method of the porous drug layer is: punching 260 holes with a diameter of 0.2 mm into the thickness of the non-woven fabric, and then soaking the non-woven fabric into 6,6'-difluoro-3,3'-biimidazo [1 , 2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide at a mass ratio of 5: 2 in the aqueous solution of the pharmaceutical composition, soaked for 30 minutes, then freeze-dried to obtain a porous drug layer .
  • the non-woven fabric tape on the bottom layer, and put a sponge layer and a porous drug layer respectively to obtain a long-acting antibacterial band-aid.
  • the area of the sponge layer is 1/3 of the area of the tape layer and the area of the porous drug layer is Said 1.3 times the area of the sponge layer.
  • Example 4 A long-acting antibacterial band-aid
  • a long-acting bacteriostatic band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 6, 6'-difluoro-3, 3'-biimidazo [1,2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide porous drug layer 2, the sponge layer is located on the adhesive tape layer and the porous drug Between layers.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is: dissolving chitosan in an acetic acid solution with a mass percentage of 0.1% to obtain a concentration of 3mg / mL chitosan solution, and dissolving cellulose in deionized water to obtain a concentration of 3mg / mL fiber
  • a plain solution mix the two solutions in a volume ratio of 5: 3, freeze-dry, and squeeze to form a sponge layer with a thickness of 0.4 mm.
  • the preparation method of the porous drug layer is: punching 200 holes with a diameter of 0.1 mm in the thickness of the nonwoven fabric, and then soaking the material room to 6,6'-difluoro-3,3'-biimidazo [1 , 2-a] pyridine and 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide at a mass ratio of 5: 3 in an aqueous solution of the pharmaceutical composition, soaked for 40 minutes and freeze-dried to obtain a porous drug layer .
  • the non-woven fabric tape on the bottom layer, and put a sponge layer and a porous drug layer, respectively, to obtain a long-acting antibacterial band-aid.
  • the area of the sponge layer is 2/5 of the area of the tape layer, and the area of the porous drug layer is 1.2 times the area of the sponge layer.
  • a long-acting bacteriostatic band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 6, 6'-difluoro-3, 3'-biimidazo [1,2-a] Pyridine porous drug layer 2, the sponge layer is located between the tape layer and the porous drug layer.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is the same as that in Example 3.
  • Example 3 The difference from Example 3 is that the porous drug layer contains only 6,6'-difluoro-3,3'-biimidazo [1,2-a] pyridine and does not contain 5-hexanoyl-2-methyl -N-o-tolyl-3-carboxamide.
  • a long-acting antibacterial band-aid includes a tape layer 1, a sponge layer composed of chitosan and cellulose 3, 5-hexanoyl-2-methyl-N-o-tolyl-
  • a porous drug layer 2 composed of 3-formamide, the sponge layer is located between the adhesive tape layer and the porous drug layer.
  • the tape layer is a non-woven tape.
  • the preparation method of the sponge layer is the same as that in Example 3.
  • Example 3 The difference from Example 3 is that the porous drug layer only contains 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide and no 6,6'-difluoro-3,3'- Biimidazo [1,2-a] pyridine.
  • Test materials Band-Aids prepared in Example 1, Example 2, Example 3, Example 4, Comparative Example 1 and Comparative Example 2.
  • Test method The prepared 6 groups of band-aid were sterilized by ultraviolet irradiation and inoculated with Escherichia coli and Staphylococcus aureus at a concentration of 8.0 ⁇ 104CFU / piece, and the number of bacteria was tested after 30 minutes.
  • Example 3 has a significantly better bacteriostatic effect than other examples, and is the best example of the present invention.

Abstract

L'invention concerne un pansement antibactérien à action prolongée, comprenant une couche de ruban adhésif (1), une couche d'éponge (3) composée de chitosane et de cellulose, et une couche poreuse de médicament composée de 6,6'-difluoro-3,3'-biimidazo[1,2-a]pyridine et de 5-hexanoyl-2-methyl-N-o-tolyl-3-carboxamide, la couche d'éponge (3) étant située entre la couche de ruban adhésif (1) et la couche poreuse de médicament (2). Le pansement comprend une couche poreuse de médicament (2), et les médicaments contenus peuvent inhiber efficacement la prolifération de bactéries, tandis que le sang et le fluide tissulaire d'une plaie peuvent pénétrer dans la couche d'éponge (2) par de petits pores tandis que les médicaments sont libérés ; pendant ce temps, la couche d'éponge (2) peut absorber rapidement le sang et le fluide tissulaire, a un effet antibactérien, peut maintenir plus efficacement un environnement stérile et favorise la cicatrisation d'une plaie.
PCT/CN2019/000112 2018-11-02 2019-05-27 Pansement antibactérien à action prolongée WO2020087765A1 (fr)

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CN201811298085.0A CN109289078B (zh) 2018-11-02 2018-11-02 一种长效抑菌创可贴
CN201811298085.0 2018-11-02

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Publication number Priority date Publication date Assignee Title
CN109289078B (zh) * 2018-11-02 2020-06-19 广东药科大学 一种长效抑菌创可贴
CN114010835A (zh) * 2021-10-28 2022-02-08 安徽同力新材料有限公司 一种有助于愈合的超高滤医用透气包生产工艺

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CN205359798U (zh) * 2015-12-28 2016-07-06 浙江科技学院 一种含有氧化再生纤维素的创可贴
WO2017133994A1 (fr) * 2016-02-04 2017-08-10 Syngenta Participations Ag Dérivés à activité pesticide comportant des substituants contenant du soufre et du cyclopropyle
CN107496973A (zh) * 2017-09-27 2017-12-22 广州润虹医药科技股份有限公司 一种快速止血壳聚糖海绵垫创可贴及其制备方法
CN109289078A (zh) * 2018-11-02 2019-02-01 广东药科大学 一种长效抑菌创可贴

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CN2902243Y (zh) * 2005-12-29 2007-05-23 郭冬梅 可减轻疼痛吸收渗液的创可贴
CN103027788B (zh) * 2013-01-05 2014-11-19 武汉奥绿新生物科技有限公司 一种可吸收性医用敷料的制备方法
CN204169985U (zh) * 2014-09-29 2015-02-25 广东泰宝医疗科技股份有限公司 一种复合型护创敷料
CN104841002B (zh) * 2015-05-21 2017-04-19 福建农林大学 一种纯天然驱蚊创可贴及其制备方法
CN204890358U (zh) * 2015-08-25 2015-12-23 广东泰宝医疗科技股份有限公司 一种缓释抗菌型高吸液性泡沫敷料

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
CN1049502A (zh) * 1989-08-17 1991-02-27 比彻姆集团公司 制备抗病毒化合物的方法
CN205359798U (zh) * 2015-12-28 2016-07-06 浙江科技学院 一种含有氧化再生纤维素的创可贴
WO2017133994A1 (fr) * 2016-02-04 2017-08-10 Syngenta Participations Ag Dérivés à activité pesticide comportant des substituants contenant du soufre et du cyclopropyle
CN107496973A (zh) * 2017-09-27 2017-12-22 广州润虹医药科技股份有限公司 一种快速止血壳聚糖海绵垫创可贴及其制备方法
CN109289078A (zh) * 2018-11-02 2019-02-01 广东药科大学 一种长效抑菌创可贴

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