WO2020080317A1

WO2020080317A1 - Body odor component reducer and body odor suppressor using same

Info

Publication number: WO2020080317A1
Application number: PCT/JP2019/040345
Authority: WO
Inventors: 繁直岡部; 村井　弘道
Original assignee: オリザ油化株式会社
Priority date: 2018-07-09
Filing date: 2019-10-13
Publication date: 2020-04-23
Also published as: JP2020026422A; JP6547050B1

Abstract

[Problem] The purpose of the present invention is to provide a novel body odor component reducer. [Solution] The technical feature of the present invention for solving the above problem is described below. 1. A body odor component reducer having as an active ingredient a plant extract containing thymoquinone. 2. The body odor component reducer according to 1. above, wherein the plant extract is black cumin extract. 3. A body odor component reducer having thymoquinone as an active ingredient. 4. The body odor component reducer according to any one of 1. through 3. above, wherein the body odor component is at least one species selected from butyric acid and isovaleric acid. 5. A body odor component reducer having black cumin extract as an active ingredient. 6. A body odor component reducer characterized in that the body odor component is at least one species selected from butyric acid, isovaleric acid, diacetyl, and ammonia.

Description

Body odor component reducing agent and body odor inhibitor using the same

The present invention relates to a body odor component reducing agent. The present invention is widely used for cosmetics and the like.

Human body odor extends to the entire body such as sweat odor, scalp odor, foot odor, etc. In particular, axillary odor is said to be a odor that makes people dislike, and in recent years, its effective and continuous prevention. It is widely desired to provide improvement methods.

The human body odor is said to be caused by the sweat secreted from the apocrine gland being mixed with sebum, which is then decomposed by skin-resident bacteria. Unlike the eccrine gland, the apocrine gland, which secretes sweat that causes axillary odor, is often found in the axilla, areola, genital area, etc., but is not localized in those areas and is widely present in the trunk. (See Non-Patent Document 1), and in recent years, where cleanliness has been increasing, it has been an issue to continuously remove such axillary odor.

Also, it is known that there are various types of substances that cause body odor, in addition to fatty acids (see Non-Patent Document 2) and male hormone derivatives (see Non-Patent Documents 3 and 4). In particular, butyric acid, caproic acid and the like are known as substances that cause axillary odor.

However, it has an antibacterial action against bacteria (body odor-related bacteria) mainly related to the generation of body odor among the skin indigenous bacteria and a deodorant action against unpleasant body odor, is inexpensive, and is highly safe. There is a strong consumer demand for odorants, and there is a strong demand for the development and provision of new antibacterial agents for body odor-related bacteria and deodorants for unpleasant body odors.

In addition, it is said that the foot sweats much more than other parts of the body, and bacteria can easily propagate with nutrients from the dead skin cells, which may give off a bad odor in shoes. . This tendency becomes even stronger in shoes with poor breathability, such as women's boots. The main component of this odor is isovaleric acid, which is a lower fatty acid.

Furthermore, in recent years, the presence of a peculiar body odor, which is mainly seen in men and women after middle-aged and older, has attracted attention. This body odor is mainly found in men in their 30s and 40s, and is mainly divided into those caused by diacetyl and those more aged in older generations caused by nonenal. The odor is commonly called the middle fat odor, and the odor caused by nonenal is commonly called the aging odor. Studies have been conducted on a method of deodorizing these, for example, a deodorant containing ε-polylysine or a salt thereof as an active ingredient is disclosed as a deodorant for reducing or eliminating the odor of nonenal. (See Patent Document 1).

Also, there are various types of body odor, such as the smell of sweat from sweating and the odor of aging, but one of the body odors is the fatigue odor. Originally, ammonia in the body is excreted together with urine, but it is also dissolved in sweat or released as skin gas. Due to the fatigue of the body, the liver function may be weakened and the function may not work properly (correctly), and the rate of release to the outside of the body by skin gas or sweat may increase. That is, the fatigue odor is a odor generated due to the ammonia, which is originally to be treated in the body and whose amount is released outside the body due to weakening of the treatment due to fatigue and the like (Patent Document 2).

There are various types of skin-resident bacteria. Some skin-resident bacteria are associated with body odor. Therefore, antibacterial agents that exert effects against these bacteria are being actively searched. However, in a form that can be generally used as a composition for external use for skin such as cosmetics or quasi drugs, existing antibacterial agents are not effective against some bacteria, and such bacteria include, for example, Corynebacterium. . Corynebacterium is a type of eubacterium that is classified into actinomycetes in terms of biological classification, and is a bacterium that has a large amount of metabolism of lower fatty acids (isovaleric acid), which have an unpleasant odor, among skin-resident bacteria. Yes, the reproduction of this bacterium is likely to cause an unpleasant odor. Therefore, in order to suppress body odor, it is effective to suppress or sterilize the reproduction of Corynebacterium. Corynebacterium xerosis is known as a body odor bacterium in the genus Corynebacterium.

In addition, the axillary odor, which is a unique odor that makes you feel a nose among body odors, is not limited to Corynebacterium, which has apocrine sweat that is secreted from the apocrine sweat glands in the axilla, but also Staphylococcus Cocci, Staphylococcus epidermidis, etc.) are caused by decomposition. Therefore, in order to suppress body odor, it is effective to suppress or sterilize the growth of these staphylococci.

On the other hand, it is known that thymoquinone, which is one of the components contained in black cumin, has an action of suppressing methyl mercaptan, which is a causative component of bad breath (Patent Document 3).

JP, 2014-151137, A JP, 2012-144458, A JP, 2011-168554, A

However, in the above-mentioned Patent Document 3, it is known that thymoquinone or the like suppresses methyl mercaptan which is a halitosis component, but it does not reduce body odor components such as butyric acid, isovaleric acid, ammonia, and nonenal. unknown.
Furthermore, it is not known that a plant extract containing thymoquinone suppresses the reproduction of Corynebacterium and Staphylococcus, which are body odor-causing bacteria.
The present inventor has found that black cumin and thymoquinone, which is a component contained therein, have a function of reducing body odor components such as butyric acid, isovaleric acid, ammonia, and nonenal, and further corynebacteria which is a body odor-causing bacterium. The present invention was completed by the finding that it suppresses the reproduction of genus Ume and staphylococci.
That is, an object of the present invention is to provide a novel body odor component reducing agent and a body odor-causing bacterium growth inhibitor.

The technical features of the present invention for solving the above problems are as follows.
1. A body odor component reducing agent containing a plant extract containing thymoquinone as an active ingredient.
2. The plant extract is a black cumin extract. The body odor component-reducing agent according to.
3. A body odor reducing agent containing thymoquinone as an active ingredient.
4. The body odor component is at least one selected from butyric acid, isovaleric acid, and nonenal. ~ Above 3. The body odor component reducing agent according to any one of 1.
5. A body odor reducing agent containing black cumin extract as an active ingredient.
6. The body odor component reducing agent, wherein the body odor component is at least one selected from butyric acid, isovaleric acid, ammonia and nonenal.
7. A body odor-causing bacterium growth inhibitor containing a plant extract containing thymoquinone as an active ingredient.
8. 7. The plant extract is a black cumin extract. The body odor-causing bacterium growth inhibitor according to 1.
9. 7. The above-mentioned body odor-causing bacterium is at least one selected from Corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis. Or 8. The body odor-causing bacterium growth inhibitor according to 1.
10. The above-mentioned Corynebacterium genus is Corynebacterium xerosis (Corynebacterium xerosis) above 9. The body odor-causing bacterium growth inhibitor according to 1.
11. The above 10. ~ Above 11. A body odor inhibitor containing the agent according to any one of claims as an active ingredient.
12. A method for reducing the body odor component (at least one selected from butyric acid, isovaleric acid, ammonia and nonenal) in human by applying an effective amount of thymoquinone or a black cumin extract containing thymoquinone to human skin.
13. By applying an effective amount of thymoquinone or a black cumin extract containing thymoquinone to human skin, a odor-causing bacterium in the human (at least one selected from Corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis) To suppress the growth of.

The body odor component reducing agent of the present invention can reduce the component causing the body odor component. Therefore, it has an effect as a deodorant on body odor caused by these components. In particular, thymoquinone and a plant extract containing thymoquinone have an action of reducing butyric acid, isovaleric acid, and nonenal among the components causing body odor. Thereby, the plant extract containing thymoquinone and thymoquinone, butyric acid, which is a causative component such as axillary odor, is a causative component such as axillary odor, and isovaleric acid is a component that causes foot odor. It can be used as a specialized deodorant.
Further, the body odor component reducing agent containing the black cumin extract as an active ingredient has a reducing action not only on butyric acid, isovaleric acid and nonenal, but also on ammonia which causes fatigue odor. This is useful as a deodorant for not only side odors and foot odors but also fatigue odors.
Further, the present invention has an action of suppressing the growth of bacteria causing causative body odor such as lower fatty acid (isovaleric acid). Thereby, it has an effect as a deodorant on body odor caused by these components.
In particular, thymoquinone and a plant extract containing thymoquinone have an action of suppressing the growth of Corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis among the bacteria causing body odor. It has an effect as a deodorant for suppressing body odor caused by body odor such as lower fatty acid (isovaleric acid). Further, it is possible to suppress the growth of Corynebacterium xerosis, in particular, of the genus Corynebacterium.
From the above, the thymoquinone and black cumin extracts are useful as body odor inhibitors.

It is a graph which shows the body odor component (acetic acid) reduction effect in a black cumin extract. It is a graph which shows the body odor component (butyric acid) reduction effect in a black cumin extract. It is a graph which shows the body odor component (isovaleric acid) reduction effect in a black cumin extract. It is a graph which shows the body odor component (ammonia) reducing action in a black cumin extract. It is a graph which shows the body odor component (diacetyl) reducing action in a black cumin extract. It is a graph which shows the body odor component (butyric acid) reducing action in thymoquinone. It is a graph which shows the body odor component (isovaleric acid) reduction effect in thymoquinone. FIG. 6 is a graph showing a comparison (total score) of odors by site and age in a black cumin extract. 3 is a graph showing a comparison of odors (sweat odor) by site and age in a black cumin extract.

The present invention will be described in detail below.
The body odor component reducing agent of the present invention is characterized by using thymoquinone or a plant extract containing thymoquinone as an active ingredient.
Thymoquinone is a compound represented by the following chemical formula (1).

The type of plant containing thymoquinone is not particularly limited. Examples include Eupatorium cannabinum of the genus, Juniperus communis of the genus Juniperus of the cypress family, Nigella sativa of the genus Scutellaria of the buttercup family, and Nigella sativa (also called black cumin) is particularly preferable. This is because thymoquinone is contained in a high concentration and an extract with a high concentration can be easily obtained.

The scrotum of the present invention (Nigella sativa or black cumin, hereinafter simply referred to as "black cumin") has a high content of volatile components such as thymoquinone in seeds, and it is preferable to use seeds.

When the black cumin extract is used as the raw material of the present invention, the extraction method is not particularly limited, and examples thereof include supercritical extraction and solvent extraction. Of these, supercritical extraction is preferred. This is because a higher concentration of thymoquinone can be obtained.
When an extract of black cumin is obtained by a supercritical extraction method, the solvent used in the supercritical extraction is preferably a solvent having a critical temperature of 600 K or lower, for example, carbon dioxide or a saturated hydrocarbon (preferably carbon). Examples thereof include saturated hydrocarbons having 1 to 4 carbon atoms and lower alcohols (preferably monohydric alcohols having 1 to 4 carbon atoms). Such solvents may be used alone or in combination of two or more. When two or more solvents are mixed and used, at least one solvent may be in a supercritical state.

Carbon dioxide is preferred as the solvent used for supercritical extraction because it has a relatively low critical temperature and is easy to handle.

In supercritical extraction using carbon dioxide, the extract can be separated from carbon dioxide by lowering the pressure after extraction. When other solvent such as lower alcohol is used in addition to or instead of carbon dioxide, the pressure is reduced after the extraction to separate the carbon dioxide, and then, if necessary, reduced pressure or the like. The other solvent may be removed.

When solvent extraction is performed as an extraction method, the extraction solvent for obtaining the extract is, for example, water, a lower monohydric alcohol (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2- Butanol, etc.), liquid polyhydric alcohol (glycerin, propylene glycol, 1,3-butylene glycol, etc.), lower ester (ethyl acetate, etc.), hydrocarbon (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.) , Ethers (diethyl ether, tetrahydrofuran, dipropyl ether, etc.), acetonitrile and the like, and one or more of them can be used.

An example of a preferable extraction method is a method of using water-containing ethanol or water-containing methanol having a concentration of 0 to 100% (v / v) at room temperature or after heating for 1 to 10 hours for extraction, followed by filtration. Can be mentioned.

As the body odor component reducing agent of the present invention, the plant extract containing thymoquinone may be used as it is, or thymoquinone itself may be used. In the present invention, when thymoquinone itself is used, a commercially available product may be used, or the thymoquinone-containing plant extract may be purified.

The above-mentioned thymoquinone and the plant extract containing thymoquinone can reduce butyric acid, isovaleric acid, and nonenal which are components of body odor.

Further, the body odor component reducing agent of the present invention is characterized by using a black cumin extract as an active ingredient.
The black cumin extract can be produced by the method described above.

Since the black cumin extract contains thymoquinone, butyric acid, isovaleric acid, and nonenal can be reduced, and diacetyl, acetic acid, and components such as ammonia that cannot be expected to have a reducing action in thymoquinone Has a reducing effect.

The above-mentioned thymoquinone, a plant extract containing thymoquinone, and a black cumin extract are blended with various forms of bases used for a body odor component-reducing agent according to a conventional method as an active ingredient to prepare a formulation. By doing so, a body odor component reducing agent can be obtained, but by further combining with other medicinal agents and the like, a body odor component reducing agent that synergistically enhances these effects can be obtained.

Moreover, the plant extract containing the thymoquinone and the black cumin extract function as a growth inhibitor for body odor-causing bacteria.
Particularly, it functions as a growth inhibitor for Corynebacterium, which is a causative bacterium of lower fatty acid (isovaleric acid), etc., which has an unpleasant odor, and Staphylococcus. Among the genus Corynebacterium, in particular, the growth of Corynebacterium xerosis can be suppressed.

The body odor component-reducing agent and the body odor-causing bacteria growth inhibitor of the present invention (hereinafter referred to as "body odor component-reducing agent, etc.") can be used as a skin external preparation (including cosmetics, pharmaceuticals and quasi-drugs) It can be expected to reduce the components and suppress the growth of bacteria causing body odor.
Examples of the form of the external preparation for skin in which the body odor reducing agent of the present invention and the like can be mixed include, for example, emulsion, soap, face wash, bath agent, cream, emulsion, lotion, cologne, shaving cream, shaving lotion. , Cosmetic oil, suntan / sunblock lotion, powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo, Examples include rinses, hair dyes, dispersions, and cleaning agents. In addition, examples of the form of the drug or quasi drug in which the body odor component reducing agent of the present invention and the like can be incorporated include ointments, creams, external preparations and the like.

In addition to the body odor component-reducing agent according to the present invention, the above-mentioned forms of skin external preparations can be used in cosmetics, quasi-drugs and other skin external preparations within a range that does not impair the body odor component-reducing action and body odor-causing bacteria growth inhibitory action. Ingredients, oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. It can be blended. Examples are listed below, but the present invention is not limited to these examples.

(1) Examples of oils Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Acid diisopropylate, neopentanoic acid isoaralkyl, tri (capryl / capric acid) glyceryl, tri-2-ethylhexanoate trimethylolpropane, triisostearate trimethylol Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyl dodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate cetostearyl, 2-ethylhexanoate stearyl, hexyl isostearate, dioctanoic acid ethylene glycol , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisolate Glyceryl palmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isostearyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin olein Acid ester, polyglycerin isostearic acid ester, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl hydroxystearate, cholesteryl hydroxystearate, olein. Cholesteryl acidate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate a Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon-based oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, vaseline and the like.
Animal and vegetable oils and hydrogenated oils thereof, and naturally derived waxes: animal oils such as beef tallow, hydrogenated beef tallow, lard, hydrogenated lard, horse oil, hydrogenated horse oil, mink oil, orange laffy oil, fish oil, hydrogenated fish oil, egg yolk oil and the like. Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot kernel oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil , Vegetable oils such as sunflower oil, grape seed oil, jojoba oil, hydrogenated jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hydrogenated cottonseed oil, coconut oil, hydrogenated coconut oil and their hardening , Beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Silicone, trimethylsiloxysilicic acid, silicone RTV rubber and the like can be mentioned.
Fluorine-based oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.

(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.

(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.

(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylate Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-paraparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, paramethoxyhydrocinnamic acid diethanolamine salt, diisopropyl diisopropylcinnamate Stell mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidine 2-ethylhexyl propionate and the like, and polymer derivatives and silane derivatives of these are included.

(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other pigments, Yellow 4 AL lake, Yellow 203 BA lake and other lake pigments, nylon powder , Silk powder, Urethane powder, Teflon (registered trademark) powder, Silicone powder, Polymethylmethacrylate powder, Cellulose powder, Starch, Silicone elastomer spherical powder, Polyethylene powder and other polymers, Yellow iron oxide, Red iron oxide, Black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine blue and dark blue, white pigments such as zinc oxide, titanium oxide and cerium oxide, body pigments such as talc, mica, sericite, kaolin and barium sulphate, titanium mica. Pearl pigments such as, barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Rica, inorganic powder such as alumina, aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, and other metal soaps, bentonite, smectite, boron nitride and the like. To be There is no particular limitation on the shape (spherical shape, rod shape, needle shape, plate shape, irregular shape, flake shape, spindle shape, etc.) and particle diameter of these powders. These powders are conventionally known surface treatments, for example, fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, It may or may not be surface-treated in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment and the like.

(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acylsulfonate, alkylsulfonate, alkylallylsulfonate, alkylnaphthalenesulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkylphosphate, POE alkylphosphate, alkylamidephosphate, alkyloylalkyltaurine salt, N-acylamino acid salt, POE alkyl ether carboxylate, alkylsulfosuccinate, alkylsulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester and the like can be mentioned.
Cationic surfactant: alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, behenyl trimethyl ammonium bromide, benzalkonium chloride , Behenic acid chloride amidopropyldimethylhydroxypropylammonium, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salt and the like.
Amphoteric surfactants: carboxybetaine type, amidobetaine type, sulfobetaine type, hydroxysulfobetaine type, amidosulfobetaine type, phosphobetaine type, aminocarboxylic acid salt type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: Propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid and the like can be mentioned.
Natural surfactants: lecithin, saponin, sugar-based surfactants and the like.

(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. Further, these chemically modified products and the like can also be used.

(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoo Kagaku), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanoate copolymer (28-2930, NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (Rubimer , BASF), vinylpyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubiscol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinylpyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinylpyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxyvinyl polymer (Carbopol, BF Goodrich), an acrylic acid / alkyl methacrylate copolymer (Pemulene, manufactured by BF Goodrich), an anionic polymer compound, an acetic acid amphoteric dialkylaminoethyl methacrylate polymer (Yukaformer, manufactured by Mitsubishi Chemical), Amphoteric polymer compounds such as octyl acrylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternary vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as de / vinylpyrrolidone copolymer (Rubicoat, manufactured by BASF), polyvinylpyrrolidone (Rubiscor K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (Rubiscor VA, manufactured by BASF) ), Vinylpyrrolidone / dimethylaminoethylmethacrylate copolymer (Copolymer 937, ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethylmethacrylate copolymer (Copolymer VC713, ISP), etc. There is. In addition, cellulose or its derivative, keratin and collagen or its derivative, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino. Naturally-derived polymer compounds such as galactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be preferably used.

(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that give some kind of physiological activity to the skin when applied to the skin. For example, whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair growth agents, moisturizers, blood circulation promoters, antibacterial agents, bactericides, drying agents, A cooling sensation, a warming sensation, vitamins, amino acids, a wound healing promoter, a stimulant alleviation agent, an analgesic, a cell activating agent, an enzyme component and the like are included. Examples of these suitable components include, for example, ashitaba extract, avocado extract, armature extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, agets. Extract, Chinese cabbage leaf extract, sardine extract, psyllium extract, scutellaria extract, barley extract, St. John's wort extract, sardine extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk , Chamomile extract, carrot extract, sagebrush extract, licorice extract, karkade extract, oyster extract, kina extract, cucumber extract, guanosine, gardenia extract, kumazasa extract, clarae Kiss, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, cinnamon extract, psycho extract. , Saitai extract, salvia extract, sapon extract, sasa extract, hawthorn extract, hawthorn extract, shiitake extract, dio extract, shikon extract, perilla extract, linden extract, spirea extract, peony extract, ginger root extract, birch extract, horse mackerel extract, horseradish extract. Witch extract, hawthorn extract, Sambucus nigra extract, yarrow extract, mint extract, sage extract, mallow extract, senki Ginseng extract, senburi extract, soybean extract, turmeric extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, quince extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, Hibiscus extract, Bakumondo extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikikoshi extract, Bisabolol, Loquat extract, Fukitampo extract, Fukinoto extract, Bukurou extract, Butcher bloom extract, Grape extract, Propolis, Loofah extract, Safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, pine extract, horse chestnut extract, hornbill Kiss, Mucrose extract, Melissa extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Forsythia extract, Rose extract, Rosemary extract, Roman chamomile extract , Royal jelly extract and the like.
In addition, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed egg shell membrane, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate. , Betaine, whey, moisturizing components such as trimethylglycine, sphingolipids, ceramides, phytosphingosine, cholesterol, cholesterol derivatives, oil components such as phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Immunostimulants such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester Vitamins, allantoin, diisopropylamine dichloroacetate, active ingredients such as 4-aminomethylcyclohexanecarboxylic acid, tocopherols, carotenoids, flavonoids, tannins, lignans, saponins and other antioxidants, α-hydroxy acids, β-hydroxy acids, etc. Cell enhancer, γ-oryzanol, blood circulation promoter such as vitamin E derivative, retinol, wound healing agent such as retinol derivative, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, etc. Whitening agent, cepharanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pan Totenyl alcohol, acetylpantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, tacanal, camphor, salicylic acid, nonyl acid vanillyl amide, nonanoic acid vanillyl amide, piroctone Olamine, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantharitin tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, monostearate Examples include hair-growing agents such as polyoxyethylene sorbitan, peppermint oil, and Sasanishiki extract.

(10) Examples of antioxidants Sodium hydrogen sulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, trilubiguanide, nordihydroguaiaretinic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy. Examples thereof include toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoids, flavonoids, tannins, lignans, saponins, apple extracts, and plant extracts having an antioxidant effect.

(11) Examples of solvents Purified water, ethanol, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, volatile linear silicones, next-generation CFCs and the like can be mentioned.

Hereinafter, the present invention will be described based on examples.
Example 1. Preparation of Black Cumin Extract In this example, black cumin seeds were crushed and extracted by supercritical extraction to obtain a black cumin extract.
HPLC analysis of the components contained in the above extract revealed that 3.7 wt% or more of thymoquinone was contained.
2. In this example, thymoquinone used was "SIGMA-ALDRICH".

Test Example 1: Evaluation of body odor component reducing action in black cumin extract After setting the room temperature to 24-26 ° C and stabilizing the room temperature, a malodorous substance is specified in the odor bag 3L (Omi Odo Air Service Co., Ltd.) Immediately after injecting the amount, air was filled until the odor bag became full, then the odor bag was sealed and left for 10 minutes (odor bag A). Separately, a specified amount of the sample was injected into a new odor bag (odor bag B).
Then connect the odor bag A and the odor bag B between the tubes, transfer all the gas in the odor bag A to the odor bag B, immediately seal and leave for 10 minutes, then use the dedicated gas detector tube (made by Gastec Co.) to The residual concentration of the malodorous substance was measured. In the test, n = 3 was set for each sample, and the deodorization rate was calculated by the following formula to calculate the average value. In the blank, the same operation was performed without injecting the sample, and the residual concentration of the odorous substance was measured. The calculation method of the malodorous substance reduction rate, the malodorous substance, the sample, and the test tube used in this test are as follows.

Malodor substance reduction rate (%) = {(blank value)-(sample value)} / (blank value) X 100
[Odor substance and specified amount]
a. Acetic acid (Wako Pure Chemical, special grade, diluted 100 times, and used 10 μL)
b.n-Butyric acid (Tokyo Kasei, special grade, 10 μL after 10-fold dilution)
c. Isovaleric acid (Tokyo Kasei, special grade, after 10-fold dilution, use 10 μL)
d. Ammonia (Kishida formation, special grade, after 10-fold dilution, use 5 μL)
e. Diacetyl (Tokyo Kasei, stock solution, 1 μL used)
[Specimen and prescribed amount]
Black cumin extract of Example 1 (containing 3.7% thymoquinone)

[Gas detector tube]
Gastec gas detector tube No. 81L Acetic acid / used for acetic acid Gastec gas detector tube No. 81 Used for acetic acid / n-butyric acid, isovaleric acid Gastec gas detector tube No. 3L For ammonia / ammonia Used Gastec gas detector tube No. 92 Used for acetaldehyde / diacetyl

Results in Test Example 1 and Effects of Examples Results in Test Example 1 are shown in Table 1 and FIG. 1 (acetic acid), FIG. 2 (butyric acid), FIG. 3 (isovaleric acid), FIG. 4 (diacetyl), and FIG. 5 (ammonia). Shown in. In the attached figures, "***" means p <0.001, "**" means p <0.01, and "*" means p <0.05.

As shown in the above Table 1 and FIGS. 1 to 5, it was confirmed that it has an action of reducing acetic acid butyric acid, isovaleric acid, and ammonia, which are the substances causing body odor.
Therefore, it was confirmed that the black cumin extract is useful as a body odor component reducing agent, particularly as a body odor substance reducing agent for acetic acid, butyric acid, isovaleric acid, and ammonia.

Test Example 2: Evaluation of body odor component reducing action of thymoquinone In the above test, a very high malodor suppression rate was observed for n-butyric acid, isovaleric acid and ammonia. Therefore, active components of black cumin extract against these three malodors The odor control effect of thymoquinone was investigated using thymoquinone which is one of the above. The test method, the method of calculating the rate of reduction of malodorous substances, and the malodorous substances, samples, and gas detector tubes used in this test are as follows.

[Test method and calculation method of odorous substance reduction rate]
The same method as in Test Example 1 was used.
[Odor substance and specified amount]
a.N-butyric acid (Tokyo Kasei, special grade, 10 μL after 10-fold dilution)
b. Isovaleric acid (Tokyo Kasei, special grade, after 10-fold dilution, use 10 μL)
c. Ammonia (Kishida formation, special grade, after 10-fold dilution, use 5 μL)
[Specimen and prescribed amount]
Timoquinone (SIGMA-ALDRICH)
Adjust with absolute ethanol to contain 3.7% thymoquinone, and use 0.5 mL
[Gas detector tube]
Gastec gas detector tube No. 81 Used for acetic acid / n-butyric acid and isovaleric acid Gastec gas detector tube No. 3L Used for ammonia / ammonia

Results in Test Example 2 and Effects of Examples Results in Test Example 2 are shown in Table 2 below and FIG. 6 (acetic acid), FIG. 7 (butyric acid), and FIG. 8 (isovaleric acid). It should be noted that since no odor eliminating effect was observed in the thymoquinone solution for ammonia, it was omitted from Table 2 below.

As shown in Table 2 and FIGS. 6 to 8, it was confirmed that it has an action of reducing butyric acid acetate and isovaleric acid, which are the causative substances of body odor.
Therefore, it was confirmed that thymoquinone is useful as a body odor component reducing agent, and is particularly useful as a body odor substance reducing agent for acetic acid butyric acid and isovaleric acid.

Test Example 3: Evaluation of the effect of reducing nonenal in black cumin extract After stabilizing the room temperature at 24 -26 ° C, 2-nonenal so that the gas concentration is set to 3 L in the odor bag (Omi Odo Air Service Co., Ltd.) The specified amount of each of the samples was added, and air was filled until the odor bag was full. This was left to stand, and 300 ml of gas in the bag was collected every 30 minutes in a DNPH cartridge. The DNPH derivative was eluted by passing 5 ml of acetonitrile through a DNPH cartridge in which the gas was collected. The eluate was measured by high performance liquid chromatography to calculate the concentration of 2-nonenal in the bag. The analytical conditions of the high performance liquid chromatograph and the specified amount of the sample are shown below. A blank test was conducted by performing the same operation without inserting the sample.

<High-performance liquid chromatographic analysis conditions>
Equipment used: LC-20AD (manufactured by Shimadzu Corporation)
Detector: Ultraviolet absorption height detector Column: RP-Amide, Φ 4.6 mm × 25 cm (Sigma Aldrich Japan Co., Ltd.)
Column temperature: 40 ° C
Mobile phase: A mixture of acetonitrile and water (80:20)
Mobile phase flow rate: 1.5 ml / min
Measurement wavelength: 360 nm
<Specimen and prescribed amount>
0.5 ml of black cumin extract of this example
<2-Nonenar reduction rate regulation>
Based on the measurement values measured as described above, the reduction rate of n-nonenal was calculated by the following calculation formula.
2-Nonenal reduction rate (%) = {(blank value)-(sample value)} / (blank value) x 100
The blank value shall be the initial measurement value before adding the sample, and the sample value shall be the 2-nonenal concentration every 30 minutes after the start of the test. The reduction rate of 2-nonenal over time in the result is shown in Table 3 below.

Effects of Examples in Test Example 3 As shown in Table 3, it was found that the sample to which the black cumin extract was added showed a higher decrease rate of 2-nonenal for each elapsed time as compared with the blank. .
Therefore, it was confirmed that the black cumin extract is useful as a reducing agent for 2-nonenal which is a causative component of aging odor.

Test Example 4: Evaluation of body odor-causing bacteria growth inhibitory action of black cumin extract 1. Outline of Evaluation Method of Growth Inhibitory Effect of Body Odor-Causing Bacteria The black cumin extract of this example was diluted to 50% with DMSO and used as a sample.
The test bacterial solution prepared by the following method was suspended in an agar plate medium (hereinafter referred to as "plate for sensitivity measurement") to which the sample was added by the following method, and after culturing, the minimum concentration at which bacterial growth was inhibited The minimum inhibitory concentration was used, and the minimum inhibitory concentration was used as an index for the evaluation of the growth inhibitory action of the body odor-causing bacteria (that is, when the minimum inhibitory concentration is low, it has an inhibitory effect on growth).
2. Test bacteria Test bacteria are as follows.
Test bacterium (1) Corynebacterium xerosis
Test bacterium (2) Staphylococcus aureus subsp.aureus NBRC 12732 (Staphylococcus aureus)
Test bacterium (3) Staphylococcus epidermidis NBRC 12993 (Staphylococcus epidermidis)
3. Test bacterial solution A test bacterial solution was prepared by the following method.
Test bacterium (1) Pre-culture: Soybean / casein / digest agar medium at 30 ° C ± 1 ° C for 2 days Bacterial solution preparation solution: Soybean / casein / digest medium Number of bacteria: 10 ⁶ / ml
Test strains (2) and (3) Preculture: Mueller Hinton Broth (difco), 37 ° C ± 1 ° C, 18 to 20 hours Bacterial fluid preparation solution: Mueller Hinton Broth
Number of bacteria: 10 ⁶ / ml
4. Sensitivity-measuring medium Test bacteria (1) Soybean-casein-digest agar medium Test bacteria (2) and (3) Mueller Hinton Agar (difco)
5. Plate for sensitivity measurement Sample stock solution (DMSO solution with black cumin extract concentration of 500 mg / g) and sample stock solution were further diluted with DMSO at 250 mg / ml, and a two-fold diluted solution thereof (hereinafter these are referred to as sample solutions) . Next, 1/99 amount of the sample solution was added to the medium for sensitivity measurement which was kept at 50 ° C. after sterilized dissolution, mixed sufficiently, and then dispensed into a petri dish and solidified.
6. Test method The test bacterial solution was cut on a susceptibility measuring plate with a plastic loop (inner diameter of 1 mm) for about 2 cm, and after culturing for a predetermined time, the minimum concentration at which bacterial growth was inhibited was defined as the minimum inhibitory concentration. did.
7. Plate culture conditions for sensitivity measurement Test bacterium (1) 30 ° C ± 1 ° C, 4 days Test bacterium (2) and (3) 37 ° C ± 1 ° C, 18 to 20 hours

Effect of Example in Test Example 4 The evaluation results of Test Example 4 are shown in Table 4 below.
As shown in Table 4 below, it was confirmed that it has a function of inhibiting the growth of Corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis. From this, it was confirmed that the black cumin extract is useful as a growth inhibitor for body odor-causing bacteria.

Test example 5
Test Example Black humin extract's body odor reducing effect in humans using Kunkun Body (registered trademark) 16 men aged 23 to 57 years old who fully understood the purpose of the test based on the Helsinki Declaration and obtained written consent. Was the subject. The subjects consisted of 16 people, 4 in each of their 20s, 30s, 40s, and 50s. All subjects applied the placebo lotion to the back of the ear, armpits, and soles for 5 consecutive days twice a day in the morning and evening from the eve of the first week, and the measurements were made in the morning, noon, and evening. The odor of the placebo lotion application site was measured with a Kunkun body (registered trademark) three times a day for 5 consecutive days from Monday to Friday.
From the eve of the second week, application of the sample lotion containing 1% of black cumin extract (Nigera sativa seed oil) was started, and it was applied twice a day in the morning and evening, for 5 consecutive days, and 3 times a day. The odor measurement was performed using Kunkun body (registered trademark) in the same manner as placebo.
The measurement conditions were acclimation for 15 minutes in a room adjusted to room temperature of 25 ± 4 ° C. and humidity of 60 ± 10%, and then for 2 weeks.
The lotions shown in the table below were prescribed as placebo and sample specimens.

Results and Effects of Examples in Test Example 5 The results of odor measurement when a sample lotion containing 1% of placebo lotion and black cumin extract (Nigera sativa seed oil) were applied are shown in Table 6 below.

Based on Table 6 above, the odor comparison (total score) by site and age is shown in FIG.
According to Fig. 8, odors behind the ears were slightly higher in the 20s than in the placebo application, but the odors were decreasing in the 30s, 40s, and 50s. You can see that Regarding armpits, the odor decreased in the 20s, 30s, and 50s, although it slightly increased in the 40s compared to when placebo was applied.
Regarding the soles of the feet, a decrease in odor was confirmed in all age groups when the lotion containing the black cumin extract (nigella sativa seed oil) was applied than when the placebo was applied.
In addition, based on Table 6 above, the odor comparison (sweat odor) by site and age is shown in FIG.
In both cases, the odor score on the armpits and soles was higher in the 40s than when the placebo was applied, but in other ages, a decrease in the odor intensity was confirmed.
From these, it was confirmed that the black cumin extract has an action of suppressing body odor.

Effects of Examples According to the above-mentioned Test Examples 1 and 2, the deodorizing effect on ammonia was confirmed to be effective in the black cumin extract, but not confirmed in thymoquinone. Therefore, it was confirmed that the deodorizing action of ammonia is effective as a reducing agent for ammonia, which is one of the body odor components, of black cumin extract itself.
On the other hand, the body odor reducing effects of n-butyric acid and isovaleric acid were effective in both black cumin extract and thymoquinone, and therefore these components are derived from thymoquinone, which results in black cumin. Not only the extract but also thymoquinone itself and other plant extracts containing thymoquinone were confirmed to be useful as reducing agents for these components.
Further, according to Test Example 3, it was confirmed that the black cumin extract is also useful as a nonenal reducing agent which is a causative component of aging odor.
Then, according to Test Example 4, it was confirmed that it is also useful as a growth inhibitor of corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis, which are the bacteria causing body odor.
Furthermore, according to Test Example 5, it was confirmed that the black cumin extract functions as a body odor inhibitor.

The following are compounding examples of the body odor component-reducing agent of the present invention (black cumin extract), but the following compounding examples do not limit the present invention. In addition to the following, it can be blended with a shoe sole insole, a fiber for clothing, a fiber for underwear, an antiperspirant, a disposable diaper and the like.

Formulation 1: cosmetic cream squalane 20.0 wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerin monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Body odor component reducing agent 1.0
Preservative Suitable amount Perfume Suitable amount
Purified water residue
100.0 wt%

Formulation 2: Lotion lotion ethanol 5.0 wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
PEG-60 hydrogenated castor oil 0.5
Lauroyl glutamate di (phytosteryl /
Octyldodecyl) 1.5
Body odor component reducing agent 0.1
Purified water residue
100.0 wt%

Formulation 3: Body gel macadamia nut oil 2.0 wt%
Octyldodecyl myristate 10.0
Methylphenyl polysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative Suitable amount Centella asiatica extract 1.0
Body odor component reducing agent 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0 wt%

Formulation 4: Emulsion squalane 4.0 wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic type glyceryl monostearate 1.0
Stearic acid 1.0
L-arginine 1.0
Body odor component reducing agent 0.5
Potassium hydroxide 0.1
Fragrance
Purified water residue
100.0 wt%

Formulation 14: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Body odor component reducing agent 0.5
Lanolin 0.5
Avocado oil 0.5
Pigment 1.5
Fragrance 22.0
100.0 wt%

As described above, the present invention can provide a novel body odor component reducing agent and the like.

Claims

A body odor component reducing agent containing a plant extract containing thymoquinone as an active ingredient.
The body odor component reducing agent according to claim 1, wherein the plant extract is a black cumin extract.
A body odor reducing agent containing thymoquinone as an active ingredient.
The body odor component is at least one selected from butyric acid, isovaleric acid, and nonenal. ~ Above 3. The body odor component reducing agent according to any one of 1.
A body odor reducing agent containing black cumin extract as an active ingredient.
The body odor component reducing agent according to claim 5, wherein the body odor component is at least one selected from butyric acid, isovaleric acid, ammonia, and nonenal.
A body odor-causing bacterium growth inhibitor containing a plant extract containing thymoquinone as an active ingredient.
The body odor-causing bacterium growth inhibitor according to claim 7, wherein the plant extract is a black cumin extract.
The body odor-causing bacterium growth inhibitor according to claim 7 or 8, wherein the odor-causing bacterium is at least one selected from the genus Corynebacterium, Staphylococcus aureus, and Staphylococcus epidermidis.
10. The body odor-causing bacterium growth inhibitor according to claim 9, wherein the genus Corynebacterium is Corynebacterium xerosis.
A body odor inhibitor comprising the agent according to any one of claims 1 to 11 as an active ingredient.