JP2007314472A - Body odor inhibiting agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a body odor inhibiting agent containing a new polyphenol derived from vegetables and suppressing body odor, especially aging note. <P>SOLUTION: The body odor inhibiting agent contains a polyphenol component containing at least one substance selected from (A) gallic acids, proanthocyanidins, catechins and pentagalloyl glucoses. As an alternative, the body odor inhibiting agent contains a polyphenol component containing at least one substance selected from (B) luteolin, chrysoeriol, apigenin and rosmarinic acid. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to body odor control agents derived from evening primrose seeds and perilla seeds, and also includes gallic acids, proanthocyanidins, catechins, pentagalloyl glucoses, luteolin, chrysoeriol, apigenin, and rosmarinic acid. The present invention relates to a body odor suppressing agent to be contained. The present invention is widely used as a material for foods and drinks, external preparations for skin, pharmaceuticals and the like.

Due to the recent increase in etiquette orientation, products that suppress body odor such as bad breath, side odor and sweat odor are attracting attention. At the same time, the causative substances of body odor are becoming clear as a result of recent research on body odor. For example, it is known that side odor specifically contains lower fatty acids such as pelargonic acid and capric acid.
Body odor has been shown to be affected by age in addition to everyday lifestyle and physical condition such as eating and smoking. For example, in the following Patent Document 1, the body odor generated with increasing age is named “aging odor”. In addition, as a generation mechanism thereof, (1) lipid peroxide radicals are generated by ultraviolet rays and lipoxygenase, (2) palmitoleic acid hydroperoxide is generated by lipid peroxide radicals from palmitoleic acid, which is abundant in sebum of middle-aged and elderly groups, 3) It is described that palmitoleic acid hydroperoxide is β-cleavaged to generate volatile aldehydes (octenal, nonenal, etc.).

  At present, as a method for reducing unsaturated aldehyde that is a causative substance of an aging odor, the following Patent Document 1 and Patent Document 2 include a topical skin preparation containing a lipoxygenase inhibitor, trehalose and / or maltitol. A method using a body odor suppressor has been clarified.

JP-A-11-286424 Japanese Patent Application No. 2000-269165

Under such circumstances, when focusing on polyphenols derived from perilla and evening primrose, it was found that when these derived polyphenols enter the body, the production of volatile aldehydes such as octenal and nonenal is suppressed. The polyphenols derived from perilla and evening primrose have been found to suppress body odor particularly when used for oral ingestion or for parenteral ingestion such as injections and suppositories, thereby completing the present invention.
That is, an object of the present invention is to provide a body odor inhibitor comprising a novel plant-derived polyphenol that suppresses body odor, particularly aging odor, as an active ingredient.

In order to solve the above-mentioned problems, the body odor suppressor of the present invention comprises, as an active ingredient, a polyphenol component containing component (A) at least one selected from gallic acids, proanthocyanidins, catechins, and pentagalloylglucoses. It is characterized by doing.
The body odor inhibitor of the present invention is characterized in that a polyphenol component containing at least one selected from component (B) luteolin, chrysoeriol, apigenin and rosmarinic acid is used as an active ingredient.
The body odor suppressor of the present invention includes the following components (A) and (B):
Component (A) at least one selected from gallic acids, proanthocyanidins, catechins, pentagalloylglucoses,
Component (B) A polyphenol component containing at least one of at least one selected from luteolin, chrysoeriol, apigenin and rosmarinic acid is used as an active ingredient.
The body odor inhibitor of the present invention is characterized in that a polyphenol component derived from at least one of evening primrose seed and perilla seed is an active ingredient.

Furthermore, the food-drinks of this invention contain the said body odor inhibitor of this invention, It is characterized by the above-mentioned.
Moreover, the pharmaceutical of this invention contains the said body odor inhibitor of this invention, It is characterized by the above-mentioned.

The body odor suppressor of the present invention has a strong antioxidant activity and / or lipoxygenase inhibitory activity. Therefore, ingestion of the body odor suppressor can reduce the production of aldehyde, which is one of the causes of aging odor. In particular, by taking orally, the generation of an aging odor can be effectively suppressed.
Moreover, since the food / beverage products of this invention contain the said body odor inhibitor, it is very effective in suppression of a body odor.
Furthermore, since the pharmaceutical of this invention contains the said body odor inhibitor, it is very effective for suppression of body odor.

Hereinafter, the present invention will be described in detail.
The “polyphenol” is a general term for compounds containing phenolic hydroxyl groups such as gallic acids, ellagic acids, proanthocyanidins, catechins, pentagalloylglucose, luteolin, chrysoeriol, apigenin, and rosmarinic acid. Here, the “polyphenol component” of the present invention includes, in particular, the component (A) the “gallic acid”, the “ellagic acid”, the “proanthocyanidins”, the “catechins”, the “pentagaro”. It contains "Ilglucose". These may be contained alone or in combination of two or more.

  Moreover, the said component (A) should just contain at least 1 sort (s) of (a1) gallic acids, (a2) proanthocyanidins, (a3) catechins, and (a4) pentagalloyl glucoses. However, it is more preferable that all the components (a1) to (a4) are included. It is because a body odor suppression effect increases more.

  Moreover, each content of said (a1)-(a4), when the sum total of content of the said polyphenol component is 100 mass%, (a1) 3-7 mass% of gallic acids, (a2) proanthocyanidins 55 -75 mass% (a3) catechins 4-7 mass%, (a4) pentagalloylglucoses 3-6 mass%, preferably (a1) gallic acids 4-6 mass%, (a2) proanthocyanidins 60 It is preferable to set it as -70 mass%, (a3) 5-6 mass% of catechins, and (a4) pentagalloyl glucose 4-5 mass%. It is because the high suppression effect with respect to a body odor is acquired by setting it as the said content.

  Although the method of obtaining the said component (A) is not specifically limited, It can obtain from the polyphenol derived from evening primrose. Moreover, when obtaining the said component (A) from evening primrose, it is preferable to extract from the seeds of evening primrose. This is because the component (A) is abundantly contained.

  In addition, the “polyphenol component” contains the component (B) the “luteolin”, the “chrysoeriol”, the “apigenin”, and the “rosmarinic acid”. These may contain only 1 type, may contain 2 or more types, and may contain polyphenols other than these.

  Component (B) may contain at least one of (b1) luteolin, (b2) chrysoeriol, (b3) apigenin, and (b4) rosmarinic acid. It is preferable to contain all the components of (b4). It is because the high suppression effect with respect to body odor is acquired.

  At this time, each content of said (b1)-(b4) is (B1) luteolin 1-10 mass% (B2) chrysoeriol 1-5 mass% (B3) apigenin 1-5 mass%, and (B4 ) It is preferable to set it as rosmarinic acid 20-65 mass%. It is because the high suppression effect with respect to a body odor is acquired by setting it as the said content.

  Although the method to obtain the said component (B) is not specifically limited, It can obtain from polyphenol derived from perilla and / or egoma. Moreover, when obtaining the said component (B) from perilla and / or egoma, it is preferable to extract from these seeds. This is because the above component (B) is contained abundantly.

  Moreover, although the said polyphenol component should just contain at least 1 sort (s) of the said component (A) and the said component (B), it is more preferable to contain both components (A) and (B). . It is because the high suppression effect with respect to body odor is acquired.

In addition, each component in the components (A) and (B) may be in the form of these derivatives. Specifically, esters such as alkyl esters obtained by reaction with metals such as sodium, potassium, magnesium, calcium, zinc, barium, aluminum, salts produced by ammonium, etc., alcohols, fatty acids, alkyl halides, etc. And a salt thereof, a phosphorylated compound having a phosphate group introduced therein, a sulfated compound having a sulfate group introduced therein, and a carbon chain of about C _{2 to} C ₄ such as ethylene glycol, propylene glycol and butylene glycol. In the form of alkyl ether derivatives obtained by reaction with alkylene oxides, quaternary alkyl amine derivatives produced by reaction with substrates having quaternary amines in the molecule such as glycidyl trialkyl ammonium halides and salts thereof Use Rukoto can also.

Furthermore, the polyphenol component is derived from evening primrose seeds and perilla seeds (hereinafter referred to as “polyphenol raw materials”). These may be used alone or in combination of two or more.
Furthermore, it is preferable to use defatted seeds as the polyphenol raw material. This is because the active ingredient is concentrated in the defatted product by removing the oil in the seeds. The degreasing method is not particularly limited. For example, after depressing evening primrose seeds and separating the oil, the residual oil of the pressed product may be extracted and separated with a fat-soluble organic solvent.
A preferred degreasing solvent is n-hexane. When n-hexane is used, the extracted oil can be used as an edible oil, and the extract of defatted evening primrose seeds can be easily used as a food material. The degreasing solvent is not limited to n-hexane, and other nonpolar solvents such as acetone can also be used.

Although the method of obtaining a polyphenol component from the said polyphenol raw material is not specifically limited, For example, it can obtain by extracting from the said polyphenol raw material using a polar solvent. Moreover, you may extract by supercritical extraction.
Examples of the polar solvent for extracting these include water, alcohol, acetone, and ethyl acetate. These may be used alone or in combination of two or more. Of these, water and / or alcohol are preferably used, and ethanol is more preferably used as the alcohol. In particular, it is most preferable to use hydrous ethanol.

  The ethanol concentration in hydrous ethanol as the extraction solvent is 40 to 90% by volume, preferably 60 to 80% by volume, when the total volume of hydrous ethanol is 100% by volume. This is because when the ethanol concentration is less than 40% by volume, the extraction amount of the active ingredient becomes insufficient, and when it exceeds 90% by volume, the oil content of evening primrose seeds is easily dissolved in the solvent. In addition, in order to improve the content rate of an active ingredient, ethanol extraction may be repeated at various concentrations.

As the extraction method, continuous extraction, immersion extraction, or countercurrent extraction can be employed, and any apparatus can be used at room temperature or under reflux heating.
When performing the supercritical extraction, it is preferable to use CO _2.

As a specific method, an extraction raw material (Evening Primrose seed or a defatted product thereof) is put into a treatment tank filled with an extraction solvent, and an active ingredient is eluted while stirring. For example, when water-containing ethanol is used as the extraction solvent, the extraction is performed in about 30 minutes to 2 hours using a polar solvent of about 5 to 100 times (weight ratio) of the extraction raw material. The active ingredient is eluted in the solvent, and then filtered to remove the extraction residue to obtain an extract. Thereafter, if necessary, the extract is subjected to treatments such as dilution, concentration, drying, and purification according to a conventional method to obtain an extract.
Examples of the purification method include activated carbon treatment, resin adsorption treatment, silica gel treatment, ion exchange resin treatment, liquid-liquid countercurrent distribution treatment, etc., but they are used in large quantities when added to foods and the like. However, it may be used without purification.
Further, the content of the polyphenol component contained in the alcohol extract used in the present invention is not particularly limited, but when the total mass of the alcohol extract is 100% by mass, it can be 3 to 99% by mass. . It is because the higher body odor suppression effect is shown by setting it as said range.

The body odor inhibitor of this invention can be used as a raw material of various food-drinks. Examples of foods and beverages include beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.), confectionery (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummi, tablet confectionery, etc.), noodles (Soba, udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), general foods including soups, health foods (tablets, capsules, etc.), nutrition Supplementary foods (such as energy drinks) are listed. The body odor inhibitor of the present invention may be appropriately blended with these foods and drinks.

  These foods and drinks can be blended with various ingredients depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used.

  As a specific production method, the solvent extract of the above polyphenol raw material is spray-dried or freeze-dried together with powdered cellulose, and it is easily contained in foods and drinks (instant foods, etc.) by making it into powders, granules, tablets or solutions. Can be made. Moreover, the solvent extract of the said polyphenol raw material can be melt | dissolved, for example in fats and oils, ethanol, glycerol, or these mixtures, and it can be made into a liquid state, and can be added to a drink, or can be added to a solid food. If necessary, it can be mixed with a binder such as gum arabic or dextrin to form a powder or granules and added to a beverage or a solid food.

  When the body odor suppressor of the present invention is applied to food and drink, the daily intake is 50 to 200 mg, preferably 100 to 150 mg.

  The body odor suppressor of the present invention may be used as a raw material for medicines (including pharmaceuticals and quasi drugs). It can be produced by appropriately blending the body odor inhibitor of the present invention with a raw material for a pharmaceutical preparation. Examples of the raw material for preparation that can be blended in the body odor inhibitor of the present invention include excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hydrogenated vegetable oil, kaolin, talc, etc. ), Binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, agar, sodium bicarbonate) , Calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitors (sucrose, stearin, cocoa butter, hydrogenated oil, etc.), absorption enhancers (quaternary) Ammonium base, sodium lauryl sulfate, etc.), Chakuzai (glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearates, polyethylene glycol, and the like) and the like.

The method of administering the body odor suppressor according to the present invention can generally be administered orally in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules, liquids, etc. Oral administration may also be used. When administered as a parenteral agent, it can be administered as a solution or with the addition of a dispersing agent, suspension, stabilizer, etc., by local tissue administration, intradermal, subcutaneous, intramuscular and intravenous injection, etc. it can. Moreover, it is good also as forms, such as a suppository and eye drops.
The dosage may vary depending on the administration method, medical condition, age of the patient, etc., but usually about 0.5 to 2000 mg can be administered as an active ingredient per day.
The mixing ratio of the body odor suppressor can be appropriately changed depending on the dosage form, but is usually about 0.3 to 15.0% by mass when administered orally or by mucosal absorption, when administered parenterally. Is preferably about 0.01 to 10% by mass. In addition, since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range.

  The fat metabolism promoter of the present invention may be used as a material for external preparations for skin such as cosmetics. Examples of skin external preparations that can be blended with the fat metabolism promoter of the present invention include, for example, emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shave cream, shave lotion. , Cosmetic oil, suntan / sunscreen lotion, powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo, Rinse, hair dye, dispersion liquid, cleaning agent and the like can be mentioned.

  In addition to the fat metabolism promoter according to the present invention, the external preparation for skin of the above-mentioned form, components blended in external preparations for skin such as cosmetics and quasi-drugs as long as the beauty and health maintenance effects are not impaired, oil content Higher alcohols, fatty acids, ultraviolet absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like.

Examples are listed below, but the present invention is not limited to these examples.
(1) Oil content example
Ester-based oil phase components : glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, butyl stearate, Butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, diisopropyl adipate, isoaralkyl neopentanoate , Tri (capryl / capric acid) glyceryl, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, Pentaerythritol la2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isostearyl laurate, Isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl isoleate, isopropyl isostearate, 2- Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, dioleo Ethylene glycol acid, propylene glycol dicaprate, di (caprylic / capric acid) propylene glycol, propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate Glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, Polyglycerol isostearate, dipropyl carbonate, dialkyl carbonate ( C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, citric acid Trioctyl, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate , Dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoylhydroxystearate, Examples include stearoyl hydroxy stearate stearyl, 12-stearoyl hydroxy stearate isostearyl.
Hydrocarbon oil phase components : squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil and other animal oils and Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil, perilla oil, Tea seed oil, camellia oil, corn oil, rapeseed oil, hardened rapeseed oil, palm kernel oil, hardened palm kernel oil, palm oil, hardened palm oil, peanut oil, hardened peanut oil, castor oil, hardened castor oil, sunflower oil, Vegetable oil such as grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened oil, beeswax, Acid number beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components : dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.

(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.

(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.

(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Examples include full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, and the like, polymer derivatives, silane derivatives, and the like.

(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other dyes, Yellow 4 AL lake, Yellow 203 BA lake and other lake dyes, nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and bitumen, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium sulfate plate, titanium mica Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Inorganic powders such as Rica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, bentonite, smectite, boron nitride, etc. It is done. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular shape, flake-like, spindle-like, etc.) and particle diameter. These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, The surface treatment may or may not be performed in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.

(6) Examples of surfactants
Anionic surfactant : fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl amide sulfate, alkyl phosphorus Acid salt, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfoacetate, acylated hydrolyzed collagen peptide Examples thereof include salts and perfluoroalkyl phosphate esters.
Cationic surfactant : alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants : carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant : propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant : lecithin, saponin, sugar surfactant and the like.

(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.

(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxy vinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as vinyl / vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) ), Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. There is. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.

(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Oen extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, carrot extract, cormorant extract, licorice extract, calcade extract, oyster extract, kiwi extract, kina extract, cucumber extract, guanosine, gardenia extract, kumazasae Kiss, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentian extract, Black tea extract, Yeast extract, Burdock extract, Rice bran ferment extract, Rice germ oil, Comfrey extract, Collagen, Cowberry extract, Saisin extract , Psycho extract, Saitai extract, Salvia extract, Soybean extract, Sasa extract, Hawthorn extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimotake extract, Japanese peony extract, Ginger root extract, Birch extract, Japanese cedar Extract, Kizuta extract, Hawthorn extract, Elderberry extract, Achillea millefolium extract, Atlantic mint extract, Sage extract, Zeni mallow Extract, cucumber extract, assembly extract, soybean extract, thymus extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, toki extract, toukisenka extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bacmond extract, Parsley extract, Honey, Camelis extract, Parietalia extract, Butterberry extract, Bisabolol, Biwa extract, Japanese dandelion extract, Fukinoto extract, Bukcho extract, Butcher bloom extract, Grape extract, Propolis, Loofah extract, safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, pine extract, maronier extract Citrus Extract, Mulberry Extract, Melissa Extract, Peach Extract, Cornflower Extract, Eucalyptus Extract, Yukinoshita Extract, Yakuinin Extract, Artemisia Extract, Lavender Extract, Apple Extract, Lettuce Extract, Lemon Extract, Lotus Flower Extract, Rose Extract, Rosemary Extract, Roman Chamomile Extract, royal jelly extract and the like.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Anti-inflammatory agents such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester, etc. Active ingredients such as vitamins, allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-hydroxy acid, β-hydroxy acid, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, whitening such as arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid and glutathione Agent, cephalanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pant Tenenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyroctonola Mines, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantalis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, polymonostearate Examples include hair restorers such as oxyethylene sorbitan, mint oil, and Sasanishiki extract.

(10) Examples of antioxidants Sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolyl biguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and clove extract.

(11) Examples of solvents Purified water, ethanol, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, next-generation chlorofluorocarbon and the like.

EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to this Example.

Example 1 Polyphenols derived from evening primrose seeds
(1) Preparation of sample A body odor inhibitor (Example 1) containing polyphenols derived from evening primrose seeds was prepared by the following method. That is, the raw material used in the process was the evening primrose oil. First, the pressed rice cake was crushed, refluxed with n-hexane, and the oil remaining in the pressed rice cake was removed to obtain a defatted product. Next, the defatted product was refluxed with 70% by volume ethanol, and the ethanol extract was dried to obtain an evening primrose extract (body odor suppressor).

(2) Human clinical test The following test was carried out in order to confirm the effect of suppressing aldehyde odor, which is a cause of aging odor, by oral intake of evening primrose seed extract.
Seven healthy men aged 48 to 61 years were employed as subjects in the intake group. In addition, six healthy men aged 47 to 63 years were employed as subjects in the non-intake group as controls. Subjects in the ingestion group had the test start date as day 0, and ingested 100 mg of the above-mentioned evening primrose seed extract orally daily during the test period from day 1 to day 22. Subjects in the non-dose group did not take anything. On day 0, day 8 and day 22 during the test period, the aldehyde odor of the underwear worn by the subject was measured. As the underwear worn by the subject, a cotton short sleeve of the same quality was used. The aldehyde odor was measured by the following method.

(2) Method for measuring aldehyde odor On the day before the body odor measurement, the subject took a bath by about 10:00 pm. And, after bathing, a new undergarment was worn from about 5 pm on the next day (ie, measurement day). Thereafter, the underwear after wearing for about 1 day was put in a plastic bag and heat-sealed, and left at room temperature for 1-2 hours. And the gas detection tube was inserted in the plastic bag, and the gas in a bag was attracted | sucked. The scale after aspiration was read. At this time, No. 91L for formaldehyde was used as the detection tube: the number of suctions was 5 times, and the suction time was 1.5 min / time. The results of the non-intake group subjects measured by this method are shown in FIG. 1, and the results of the ingestion group subjects group of Example 1 are shown in FIG. In FIG. 2, ** indicates a superiority difference p <0.01.
(3) Results and Discussion According to FIG. 1, there was no significant difference in the change in aldehyde odor in the non-intake group that did not take the evening primrose seed extract. On the other hand, as shown in FIG. 2, in the evening primrose seed intake group, a significant decrease in aldehyde odor was observed at the third week of intake.

(Example 2: Polyphenol derived from perilla seed)
(1) Preparation of sample The body odor inhibitor containing polyphenol derived from perilla seed was measured by the following method. The crushed perilla seed was refluxed with hexane, and the residue (defatted product) was refluxed with 80% (v / v) ethanol to obtain a perilla seed extract (body odor suppressor).

  In order to confirm the effect of suppressing the aldehyde odor, which is a cause of the aging odor, by the oral intake of the body odor suppressor of Example 2 above, the following test was performed.

(1) Test Method Six healthy men from the age of 48 to 68 were employed as subjects in the test method intake group. In addition, six healthy men aged 47 to 63 years were employed as subjects in the non-intake group as controls. Subjects in the ingestion group had the test start date as day 0, and during the test period from the first day to the 22nd day, the capsules filled with 100 mg of the perilla seed extract were orally ingested daily. Subjects in the non-dose group did not take anything. On day 0, day 8 and day 22 during the test period, the aldehyde odor of the underwear worn by the subject was measured. As the underwear worn by the subject, a cotton short sleeve of the same quality was used. The aldehyde odor was measured by the same method as in Example 1 above. In FIG. 3, * indicates a superior difference p <0.05, and ** indicates a superior difference p <0.01.

(2) Results and Discussion As shown in FIG. 1, there was no significant difference in the change in aldehyde odor in the non-intake group that did not take perilla seed extract. On the other hand, as shown in FIG. 3, in the perilla seed intake group, a significant decrease in aldehyde odor was observed in the first week of intake, and further significantly decreased in the third week of intake.

[Composition example]
The compounding example of the body odor inhibitor by this invention is shown. In addition, the following compounding examples do not limit the gist of the invention, and it is needless to say that changes can be made without departing from the gist of the present invention.
Formulation Example 1: Chewing gum
53.0% by mass of sugar
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Body odor inhibitor 0.5
100.0% by mass

Formulation Example 2: Gummy
Reduced water tank 40.0% by mass
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Yuzu fruit juice 4.0
Yuzu Flavor 0.6
Dye 0.02
Body odor suppressor 1.0
100.0% by mass

Formulation Example 3: Candy
50.0% by mass of sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Body odor inhibitor 0.4
100.0% by mass

Formulation Example 4: Yogurt (hard / soft)
Milk 41.5 mass%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Body odor inhibitor 0.4
Perfume
Water residue
100.0% by mass

Formulation Example 5: Soft drink
Fructose glucose liquid sugar 30.0% by mass
Emulsifier 0.5
Body odor inhibitor 0.1
Perfume
Purified water residue
100.0% by mass

Formulation Example 6: Tablets
76.4% by mass of sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Body odor inhibitor 0.5
Purified water 3.9
100.0% by mass

Formulation Example 7: Soft capsule
Brown rice germ oil 47.0% by mass
Yuzu seed oil 40.0
Emulsifier 12.0
Body odor suppressor 1.0
100.0% by mass

Formulation Example 8: Tablet
Lactose 54.0% by mass
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Body odor suppressor 1.0
100.0% by mass

Formulation Example 9: Cosmetic cream
Squalane 20.0wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Body odor inhibitor 2.0
Preservative appropriate amount
Perfume
Purified water residue
100.0wt%

Formulation Example 10: lotion
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Body odor inhibitor 0.1
Purified water residue
100.0wt%

Formulation Example 11: Body gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative appropriate amount
Camellia extract 1.0
Body odor suppressor 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%

Formulation Example 12: Emulsion
Squalane 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Body odor inhibitor 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%

Formulation Example 13: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Body odor inhibitor 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%

As described above, according to the present invention, the following excellent effects can be obtained.
(a) With an extract derived from evening primrose seeds and perilla seeds, an excellent body odor suppressor that can be ingested can be obtained, and the aldehyde odor associated with aging can be effectively reduced.
(b) Since it is a safe extract derived from evening primrose seeds and perilla seeds, it can be used safely as a material for foods and drinks and medicines.

It is a graph which shows the measurement result of the aldehyde odor of a non-intake group test subject (comparative example) in an Example. It is a graph which shows the measurement result of the aldehyde odor of the evening primrose seed extract intake group test subject (Example 1) in an Example. It is a graph which shows the measurement result of the aldehyde odor of the perilla seed extract intake group test subject (Example 2) in an Example.

Claims (7)

The following component (A) at least one selected from gallic acids, proanthocyanidins, catechins and pentagalloylglucoses,
A body odor suppressor comprising a polyphenol component containing sucrose as an active ingredient. Component (B) at least one selected from luteolin, chrysoeriol, apigenin and rosmarinic acid,
A body odor suppressor comprising a polyphenol component containing sucrose as an active ingredient. The following components (A) and (B)
Component (A) at least one selected from gallic acids, proanthocyanidins, catechins, pentagalloylglucoses,
Component (B) at least one selected from luteolin, chrysoeriol, apigenin and rosmarinic acid,
Body odor inhibitor which uses the polyphenol component containing at least one of these as an active ingredient.   A body odor inhibitor comprising a polyphenol component derived from at least one of evening primrose seed and perilla seed as an active ingredient.   Food-drinks containing the body odor inhibitor of any one of Claims 1-4.   The pharmaceutical containing the body odor inhibitor of any one of Claims 1-4. The skin external preparation containing the body odor inhibitor of any one of Claims 1-4.