WO2020037853A1 - 一种促进微循环、提高人体机能的组合物及其制法 - Google Patents

一种促进微循环、提高人体机能的组合物及其制法 Download PDF

Info

Publication number
WO2020037853A1
WO2020037853A1 PCT/CN2018/116644 CN2018116644W WO2020037853A1 WO 2020037853 A1 WO2020037853 A1 WO 2020037853A1 CN 2018116644 W CN2018116644 W CN 2018116644W WO 2020037853 A1 WO2020037853 A1 WO 2020037853A1
Authority
WO
WIPO (PCT)
Prior art keywords
oyster
extract
white
human body
preparation
Prior art date
Application number
PCT/CN2018/116644
Other languages
English (en)
French (fr)
Inventor
徐菀羚
曹凤君
Original Assignee
长春健康未来医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 长春健康未来医药科技有限公司 filed Critical 长春健康未来医药科技有限公司
Publication of WO2020037853A1 publication Critical patent/WO2020037853A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof

Definitions

  • the invention belongs to the field of health food, and particularly relates to an extraction composition which promotes microcirculation and improves human body functions and a preparation method thereof.
  • Macromolecular compounds are usually made into tablets that need to pass through the intestine and pancreas before being absorbed and used by the body. The degree of absorption and utilization is only about 10%.
  • CN101037468A discloses a method for preparing an oyster active peptide, which uses oysters as raw materials, hydrolyzes oyster protein by enzymatic method, and separates and purifies oyster active peptides by column chromatography to obtain high-purity oyster active peptides.
  • oyster active peptides can be developed and used as pharmaceutical ingredients, it is difficult to achieve mass production due to their high cost.
  • the present invention provides a method for preparing an extraction composition that promotes microcirculation and improves human body functions.
  • the preparation method combines a concentration, an extraction technology and a fermentation technology, can form a trace element amino acid chelate, and improves the absorption rate.
  • the scientifically formulated extraction composition that promotes microcirculation and improves human body functions can treat male erectile dysfunction caused by microcirculation disorders, relax microvessels, and relieve prostate hypertrophy.
  • the solution of the present invention is to provide a method for preparing an extraction composition that promotes microcirculation and improves human body functions, and includes the following steps:
  • the oyster active polypeptide concentrated solution is dried and crushed to obtain an oyster extract
  • the yeast is activated and treated, and then gradually expanded and cultured to obtain a seed liquid;
  • Blend fern extract, oyster extract, and yeast cells are mixed and cultured. After the sterilization is completed, an extraction composition that promotes microcirculation and improves human body functions is obtained.
  • the rotation speed of the stirring is 40 to 60 r / min
  • the stirring temperature is 10 to 20 ° C.
  • the stirring time is 1 to 2 hours.
  • the weight ratio of the baiji powder to water is 1: 1 to 3; the reflux temperature is 90 to 95 ° C, and the reflux time is 15 to 25 minutes.
  • the concentration temperature is 35 to 45 ° C, and the concentration time is 1 to 2 hours.
  • the drying temperature is 60 to 80 ° C, and the pulverized particle size is 80 to 120 mesh.
  • the weight ratio of the shelled oyster to water is 1: 3 to 5; the pressure of the cooking is 95 to 110 kPa, and the cooking time is 30 to 60 min.
  • the concentration temperature is 70 to 80 ° C, and the concentration pressure is 0.133 to 0.66 kPa.
  • the drying temperature is 70 to 80 ° C, and the pulverized particle size is 80 to 100 mesh.
  • the weight ratio of the peony extract, oyster extract and yeast body is: 3-7: 10-20: 75-85; and the fermentation temperature is 28-32 ° C. , The time is 22 to 26h.
  • the present invention also provides an extraction composition that promotes microcirculation and improves human body functions obtained by the preparation method.
  • the invention also provides an edible method for an extraction composition that promotes microcirculation and improves the function of the human body: the extraction composition can be contained in the oral cavity, which can be absorbed.
  • the extract composition for promoting microcirculation and improving human body function can mainly treat symptoms of male erectile dysfunction caused by microcirculation disorders, relax microvessels, and relieve prostate hypertrophy.
  • white pupa and oysters as the basic effective components: take the white pupa's cardiovascular dilatation effect, enhance the contraction of smooth muscle and stimulate the central nerve, and combine it with the polypeptide substance that can inhibit arginase activity in oyster , Can quickly increase the endogenous arginine level in the human body, ensure adequate supply of nitric oxide, maintain vascular patency, regulate blood pressure, and increase the concentration of cyclophosphate guanylate, so that prostate tissue and smooth muscle at the exit of the prostate and bladder Diastolic, relieves the dynamic obstruction of urination, improves the dysuria associated with prostatic hypertrophy; because many of the original active substances in oysters and white peony are digested and absorbed by live yeast, glucopolypeptide, dextran- Trace element amino acid chel
  • the method for preparing an extract composition for promoting microcirculation and improving human body function according to the present invention. After concentrating and drying white oysters and oysters into powder, fermentation with yeast can form trace element amino acid chelate, which enters the body Can be directly transported to specific target tissues and enzyme systems to help the body recognize, identify and absorb, which eliminates the biochemical process required to absorb inorganic elements, thereby improving the utilization of trace elements; and The preparation method is simple and easy to operate, and is conducive to large-scale production.
  • Figure 1 shows the effective rate of normal erectile function in groups A, B and C at 12 months.
  • Figure 2 shows the effective rate of normal erectile function in groups A, B and C at the 13th month.
  • Figure 3 shows the effective rates of normal erectile function in group A at 12th, 13th, and 18th months.
  • This embodiment provides a method for preparing an extraction composition that promotes microcirculation and improves human body functions, including the following steps:
  • the dried white scallion concentrate was dried at a temperature of 60 ° C, and then pulverized to a particle size of 110 to 120 mesh to obtain the white scallion extract;
  • the oyster slurry was concentrated under the conditions of a temperature of 70 ° C. and a pressure of 0.66 kPa to obtain a concentrated oyster active peptide solution;
  • the oyster active polypeptide concentrated solution is dried at a temperature of 70 ° C and pulverized to 95-100 meshes to obtain an oyster extract;
  • the yeast is activated and treated, and then gradually expanded and cultured to obtain a seed liquid;
  • This embodiment provides a method for preparing an extraction composition that promotes microcirculation and improves human body functions, including the following steps:
  • the oyster slurry was concentrated under the conditions of a temperature of 80 ° C. and a pressure of 0.133 kPa to obtain a concentrated oyster active polypeptide solution;
  • the oyster active polypeptide concentrated solution is dried at a temperature of 80 ° C, and then pulverized to 80-85 mesh to obtain an oyster extract;
  • the yeast is activated and treated, and then gradually expanded and cultured to obtain a seed liquid;
  • This embodiment provides a method for preparing an extraction composition that promotes microcirculation and improves human body functions, including the following steps:
  • peony root concentrate After the sterilization solution of peony root is sterilized, it is concentrated for 1.5 h at a temperature of 39 to 41 ° C to obtain a peony root concentrate;
  • the dried white scallion concentrate was dried at a temperature of 70 ° C, and then pulverized to a particle size of 95-105 mesh to obtain the white scallion extract;
  • the oyster slurry was concentrated under the conditions of a temperature of 75 ° C. and a pressure of 0.4 kPa to obtain an oyster active polypeptide concentrated solution;
  • the oyster active polypeptide concentrated solution is dried at a temperature of 75 ° C. and crushed to 85-95 mesh to obtain an oyster extract;
  • the yeast is activated and treated, and then gradually expanded and cultured to obtain a seed liquid;
  • Group A patients take it routinely, taking every two nights, taking 3g of extract composition each time for 12 months; group B patients taking it as needed, that is, when erectile dysfunction occurs, erectile function It was stopped during the normal period, and the same time, 3g of the extract composition was taken for 12 months. Group C was not taken.
  • Groups A, B, and C were continuously observed for 12 months. At the end, effective numbers were counted separately. The number of normal erectile function in group A was 22, the number of normal erectile function in group B was 21, and the erectile function in group C was normal. The number is one, and the effective results are shown in Figure 1.
  • the taking period ended after 12 months. Both the A and B groups stopped taking the extract composition. In the 13th month, effective numbers were counted in the A, B and C groups. The number of normal erectile function in the A group was 20. The number of normal erectile function in group B was 3, and the number of normal erectile function in group C was 1. The effective results are shown in Figure 2.
  • the taking period ends after 12 months.
  • the effective numbers at the 12th, 13th, and 18th months of group A were counted.
  • the results are shown in Figure 3, of which the effective number at the 12th month was 22 There are 20 valid persons in the 13th month and 19 valid persons in the 18th month.
  • both the conventional taking mode and the on-demand taking mode can achieve better effectiveness; after the end of the taking period, the effectiveness of the on-demand taking mode drops sharply, and the effect of the conventional taking mode can still be maintained. For a long time.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种促进微循环、提高人体机能的组合物及其制法，组合物由白芷、牡蛎经提取和酵母发酵制成，能够治疗因微循环障碍所致的男性勃起功能障碍、舒张微细血管及缓解前列腺肥大等症状。

Description

[根据细则37.2由ISA制定的发明名称]　一种促进微循环、提高人体机能的组合物及其制法 技术领域
本发明属于保健食品领域，具体涉及一种促进微循环、提高人体机能的提取组合物及其制法。
背景技术
市面上以牡蛎和白芷为原料的产品很多，但绝大多数的产品都是对牡蛎和白芷的精细加工，本质上并不能够改变原有牡蛎和白芷的大分子结构。大分子化合物通常作成片剂需要通过肠道、胰脏然后才被人体吸收、利用。吸收和利用的程度只有10％左右。
其中关于酶水解牡蛎蛋白的技术大多采用单酶或复合酶一步水解的酶解模式，这种酶解模式不利于牡蛎蛋白的水解，也不宜于牡蛎蛋白中生物活性序列的释放。目前有关牡蛎提取物的制备方法很多，如CN1024074涉及到一种全营养牡蛎精粉的生产方法；CN1067553C涉及到一种由新鲜活牡蛎提取有效成分的方法；CN1132646采用酶解工艺制备牡蛎成分；这些处理方法会损失牡蛎蛋白多肽中的功能成分而降低其生物学活性。另外，公开号为CN101037468A的专利公开了一种牡蛎活性肽的制备方法，以牡蛎为原料，利用酶法水解牡蛎蛋白及利用柱层析技术分离纯化获得高纯度的牡蛎活性多肽，该法所得到的牡蛎活性多肽虽然可以作为药品成分加以开发利用，但因其成本昂贵，难以实现大量生产。
发明内容
为了解决现有技术存在的问题，本发明提供了一种促进微循环、提高人体机能的提取组合物的制法。所述制备方法将浓缩、提取技术与发酵技术相结合， 能够形成微量元素氨基酸螯合物，提高了吸收率。所述促进微循环、提高人体机能的提取组合物通过科学复配后，能够治疗因微循环障碍所致的男性勃起功能障碍、舒张微细血管及缓解前列腺肥大等症状。
本发明的方案为，提供一种促进微循环、提高人体机能的提取组合物的制法，包括如下步骤：
(I)制备白芷提取物：
将白芷粉碎后搅拌均匀，得白芷粉；
将白芷粉与水混合后进行回流，完毕后过滤得白芷提纯液；
将白芷提纯液灭菌后浓缩，得白芷浓缩液；
将白芷浓缩液干燥后粉碎，得白芷提取物；
(II)制备牡蛎提取物：
将去壳牡蛎加水蒸煮，过滤后得牡蛎浆液；
将牡蛎浆液进行浓缩，得牡蛎活性多肽浓缩液；
将牡蛎活性多肽浓缩液干燥后粉碎，得牡蛎提取物；
(III)制备酵母菌体：
将酵母菌活化处理，后逐级扩大培养，得种子液；
将种子液继续发酵得发酵液，并对发酵液进行固液分离，弃去上清液，得酵母菌体；
(IV)制备促进人体微循环的提取组合物：
将白芷提取物、牡蛎提取物和酵母菌体混合发酵培养，完毕后杀菌得促进微循环、提高人体机能的提取组合物。
优选地，步骤(I)中，所述搅拌的转速为40～60r/min，搅拌温度为10～20℃，搅拌时间1～2h。
优选地，步骤(I)中，所述白芷粉与水的重量比为1:1～3；所述回流的温 度为90～95℃，回流的时间为15～25min。
优选地，步骤(I)中，所述浓缩的温度为35～45℃，浓缩的时间为1～2h。
优选地，步骤(I)中，所述干燥的温度为60～80℃，所述粉碎的粒度为80～120目。
优选地，步骤(II)中，所述去壳牡蛎与水的重量比为1:3～5；所述蒸煮的压力为95～110kPa，蒸煮时间为30～60min。
优选地，步骤(II)中，所述浓缩的温度为70～80℃，浓缩的压强为0.133～0.66kPa。
优选地，步骤(II)中，所述干燥的温度为70～80℃，所述粉碎的粒度为80～100目。
优选地，步骤(IV)中，所述白芷提取物、牡蛎提取物和酵母菌体的重量之比为：3～7：10～20：75～85；所述发酵的温度为28～32℃，时间为22～26h。
作为一个总的技术构思，本发明还提供了由所述制备方法得到的促进微循环、提高人体机能的提取组合物。
本发明还提供一种促进微循环、提高人体机能的提取组合物的食用方法：将提取组合物含于口腔中，含化吸收即可。
本发明的有益效果为：
1、本发明所述的促进微循环、提高人体机能的提取组合物，主要能够治疗因微循环障碍所致的男性勃起功能障碍、舒张微细血管及缓解前列腺肥大等症状。以白芷和牡蛎为基本有效组分：取白芷对心血管的扩张作用、对平滑肌的收缩增强作用和中枢神经的刺激作用，将其与牡蛎中的可抑制精氨酸酶活性的多肽物质相结合，能够快速提高人体内的内源性精氨酸水平，确保一氧化氮充分供应，保持血管畅通，调节血压，同时使环磷鸟苷酸积聚性浓度提高使前列腺组织以及前列腺和膀胱出口的平滑肌得以舒张，解除了排尿的动力性梗阻，改善了前列腺肥大伴有的排尿障碍；由于牡蛎和白芷内的的许多原始活性物质被活酵母消化、吸收，形成葡聚搪-多肽、葡聚糖-微量元素氨基酸螯合物，因此从牡蛎和白芷中的生物活性物质就能保持原有的生物活性和营养，其可与口 腔黏膜上的表面受体互相识别、鉴定，方便进入体内。
2、本发明所述的促进微循环、提高人体机能的提取组合物的制法，将白芷与牡蛎浓缩、干燥成粉后与酵母进行发酵，能够形成微量元素氨基酸螯合物，其进入机体后，能被直接运输到各特定的靶组织和酶系统中，帮助身体识别、鉴定和吸收，这就省去了吸收无机态元素所需的生化过程，从而提高了微量元素的利用率；且所述制备方法简单易操作，有利于规模化生产。
附图说明
图1为：第12个月时A、B和C三组勃起功能正常的有效率。
图2为：第13个月时A、B和C三组勃起功能正常的有效率。
图3为：A组分别第12个月、第13个月和第18个月时勃起功能正常的有效率。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
实施例1
本实施例提供一种促进微循环、提高人体机能的提取组合物的制法，包括以下步骤：
(I)制备白芷提取物：
将白芷粉碎后在转速为40r/min、温度为18～20℃条件下搅拌1h，得白芷粉；
将白芷粉与等重量的水混合后在温度为90℃条件下进行回流25min，完毕后过滤得白芷提纯液；
将白芷提纯液灭菌后在温度为35～37℃条件下浓缩2h，得白芷浓缩液；
将白芷浓缩液在温度为60℃条件下干燥后粉碎至粒度为110～120目，得白芷提取物；
(II)制备牡蛎提取物：
将去壳牡蛎加3倍重量的水在压力为95kPa的条件下蒸煮60min，过滤后得牡蛎浆液；
将牡蛎浆液在温度为70℃、压力为0.66kPa的条件下进行浓缩，得牡蛎活性多肽浓缩液；
将牡蛎活性多肽浓缩液在温度为70℃条件下干燥后粉碎至95～100目，得牡蛎提取物；
(III)制备酵母菌体：
将酵母菌活化处理，后逐级扩大培养，得种子液；
将种子液继续发酵得发酵液，并对发酵液进行固液分离，弃去上清液，得酵母菌体；
(IV)制备促进人体微循环的提取组合物：
将重量百分比为3％的白芷提取物、20％的牡蛎提取物和77％的酵母菌体混合，在温度为28～29℃条件下发酵培养26h，完毕后杀菌得促进微循环、提高人体机能的提取组合物。
实施例2
本实施例提供一种促进微循环、提高人体机能的提取组合物的制法，包括以下步骤：
(I)制备白芷提取物：
将白芷粉碎后在转速为60r/min、温度为10～12℃条件下搅拌2h，得白芷粉；
将白芷粉加3倍重量的水混合后在温度为95℃条件下进行回流15min，完毕后过滤得白芷提纯液；
将白芷提纯液灭菌后在温度为43～45℃条件下浓缩1h，得白芷浓缩液；
将白芷浓缩液在温度为80℃条件下干燥后粉碎至粒度为80～90目，得白芷提取物；
(II)制备牡蛎提取物：
将去壳牡蛎加3倍重量的水在压力为110kPa的条件下蒸煮30min，过滤后得牡蛎浆液；
将牡蛎浆液在温度为80℃、压力为0.133kPa的条件下进行浓缩，得牡蛎活性多肽浓缩液；
将牡蛎活性多肽浓缩液在温度为80℃条件下干燥后粉碎至80～85目，得牡蛎提取物；
(III)制备酵母菌体：
将酵母菌活化处理，后逐级扩大培养，得种子液；
将种子液继续发酵得发酵液，并对发酵液进行固液分离，弃去上清液，得酵母菌体；
(IV)制备促进人体微循环的提取组合物：
将重量百分比为7％的白芷提取物、10％的牡蛎提取物和83％的酵母菌体混合，在温度为31～32℃条件下发酵培养22h，完毕后杀菌得促进微循环、提高人体机能的提取组合物。
实施例3
本实施例提供一种促进微循环、提高人体机能的提取组合物的制法，包括以下步骤：
(I)制备白芷提取物：
将白芷粉碎后在转速为50r/min、温度为14～16℃条件下搅拌1.5h，得白芷粉；
将白芷粉加2倍重量的水混合后在温度为92℃条件下进行回流20min，完毕后过滤得白芷提纯液；
将白芷提纯液灭菌后在温度为39～41℃条件下浓缩1.5h，得白芷浓缩液；
将白芷浓缩液在温度为70℃条件下干燥后粉碎至粒度为95～105目，得白芷提取物；
(II)制备牡蛎提取物：
将去壳牡蛎加3倍重量的水在压力为100kPa的条件下蒸煮45min，过滤后得牡蛎浆液；
将牡蛎浆液在温度为75℃、压力为0.4kPa的条件下进行浓缩，得牡蛎活性多肽浓缩液；
将牡蛎活性多肽浓缩液在温度为75℃条件下干燥后粉碎至85～95目，得牡蛎提取物；
(III)制备酵母菌体：
将酵母菌活化处理，后逐级扩大培养，得种子液；
将种子液继续发酵得发酵液，并对发酵液进行固液分离，弃去上清液，得酵母菌体；
(IV)制备促进人体微循环的提取组合物：
将重量百分比为5％的白芷提取物、15％的牡蛎提取物和80％的酵母菌体混合，在温度为29～31℃条件下发酵培养24h，完毕后杀菌得促进微循环、提高人体机能的提取组合物。
为说明本发明所述的促进微循环、提高人体机能的提取组合物的效果，进行如下实验。
实验分组：共选取A、B和C三组患有勃起功能障碍的患者，其中A组34人，B组32人，C组18人。
实验方法：A组患者常规服用，方式为每隔两晚服用一次，每次服用3g提取组合物，连用12个月；B组患者按需服用，即出现勃起功能性障碍时进行服用，勃起功能正常时停用，同样每次服用3g提取组合物，维持服用12个月；C组不服用。
对A、B和C组连续观察12个月，结束时分别进行有效人数的统计，A组中勃起功能正常人数为22人，B组中勃起功能正常人数为21人，C组中勃起功能正常人数为1人，有效率结果如图1所示。
服用期在12个月后结束，A和B两组均停止服用提取组合物，在第13个月对A、B和C三组进行有效人数统计，A组中勃起功能正常人数为20人，B组中勃起功能正常人数为3人，C组中勃起功能正常人数为1人，有效率结果如图2所示。
服用期在12个月后结束，分别对A组第12个月、第13个月和第18个月时的效率人数进行统计，结果如图3所示，其中第12个月有效人数为22人，第13个月有效人数为20人，第18个月有效人数为19人。
实验结果表明：
1、由图1可得，在服用期结束后，常规服用组A与按需服用组B的有效率分别为64.7％和65.6％，表明在持续服用期间，正常服用与按需服用的方式均能对勃起功能障碍起到良好的改善效果；无服用组C只有1人勃起功能正常。
2、由图2可得，在服用期结束后一个月时，常规服用组A的有效率虽有下降，但仍能保持58.8％；按需服用组B的有效率陡降至9.4％，表明按需服用组在服用期间虽能维持较好的有效率，但停止服用后有效率相应降低，效果不能维持；无服用组C仍然只有1人勃起功能正常。
3、由图3可得，常规服用组在第12个月、第13个月和第18个月的有效率分别为64.7％、58.8％和55.9％，表明常规服用组在停止服用后，有效率仅有小幅下降，效果可持续维持较长时间。
综上所述：服用期间，常规服用方式与按需服用方式均能达到较佳的有效率；而服用期结束后，按需服用方式的有效率陡降，常规服用方式的效果仍能维持较长时间。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。

Claims (10)

  1. 一种促进微循环、提高人体机能的提取组合物的制法，其特征在于，包括以下步骤：
    (I)制备白芷提取物：
    将白芷粉碎后搅拌均匀，得白芷粉；
    将白芷粉与水混合后进行回流，完毕后过滤得白芷提纯液；
    将白芷提纯液灭菌后浓缩，得白芷浓缩液；
    将白芷浓缩液干燥后粉碎，得白芷提取物；
    (II)制备牡蛎提取物：
    将去壳牡蛎加水蒸煮，过滤后得牡蛎浆液；
    将牡蛎浆液进行浓缩，得牡蛎活性多肽浓缩液；
    将牡蛎活性多肽浓缩液干燥后粉碎，得牡蛎提取物；
    (III)制备酵母菌体：
    将酵母菌活化处理，后逐级扩大培养，得种子液；
    将种子液继续发酵得发酵液，并对发酵液进行固液分离，弃去上清液，得酵母菌体；
    (IV)制备促进人体微循环的提取组合物：
    将白芷提取物、牡蛎提取物和酵母菌体混合发酵培养，完毕后杀菌得促进微循环、提高人体机能的提取组合物。
  2. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(I)中，所述搅拌的转速为40～60r/min，搅拌温度为10～20℃，搅拌时间1～2h。
  3. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法， 其特征在于，步骤(I)中，所述白芷粉与水的重量比为1:1～3；所述回流的温度为90～95℃，回流的时间为15～25min。
  4. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(I)中，所述浓缩的温度为35～45℃，浓缩的时间为1～2h。
  5. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(I)中，所述干燥的温度为60～80℃，所述粉碎的粒度为80～120目。
  6. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(II)中，所述去壳牡蛎与水的重量比为1:3～5；所述蒸煮的压力为95～110kPa，蒸煮时间为30～60min。
  7. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(II)中，所述浓缩的温度为70～80℃，浓缩的压强为0.133～0.66kPa。
  8. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(II)中，所述干燥的温度为70～80℃，所述粉碎的粒度为80～100目。
  9. 根据权利要求1所述的促进微循环、提高人体机能的提取组合物的制法，其特征在于，步骤(IV)中，所述白芷提取物、牡蛎提取物和酵母菌体的重量之比为：3～7：10～20：75～85；所述发酵的温度为28～32℃，时间为22～26h。
  10. 权利要求1～9任一项所述的制法得到的促进微循环、提高人体机能的提取组合物。
PCT/CN2018/116644 2018-08-24 2018-11-21 一种促进微循环、提高人体机能的组合物及其制法 WO2020037853A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810970936.5A CN109170850A (zh) 2018-08-24 2018-08-24 一种促进微循环、提高人体机能的提取组合物及其制法
CN201810970936.5 2018-08-24

Publications (1)

Publication Number Publication Date
WO2020037853A1 true WO2020037853A1 (zh) 2020-02-27

Family

ID=64919456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/116644 WO2020037853A1 (zh) 2018-08-24 2018-11-21 一种促进微循环、提高人体机能的组合物及其制法

Country Status (2)

Country Link
CN (1) CN109170850A (zh)
WO (1) WO2020037853A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840343A (zh) * 2020-08-18 2020-10-30 成都蜜儿堂职业技能培训学校有限公司 一种促进人体微循环的牡蛎粉及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104172080A (zh) * 2014-08-05 2014-12-03 北海富安源生物科技有限公司 在牡蛎肉中提取氨基酸的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104172080A (zh) * 2014-08-05 2014-12-03 北海富安源生物科技有限公司 在牡蛎肉中提取氨基酸的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
11 June 2018 (2018-06-11), Retrieved from the Internet <URL:https://mp.weixin.qq.com/s?biz=MzU10DU30DM2MA%3D%3D&idx=2&mid=2247484053&sn=d67199d0541cac46f2a7f403cf58a78b> *
CHERRY SMILE, 28 May 2018 (2018-05-28), Retrieved from the Internet <URL:http://tieba.baidu.com/p/5717489839?traceid=> *

Also Published As

Publication number Publication date
CN109170850A (zh) 2019-01-11

Similar Documents

Publication Publication Date Title
CN104256584B (zh) 一种辣木酵素及其制备方法
CN103146560B (zh) 一种保健醋及其制备方法
CN101928745A (zh) 蚂蚁多肽的制备方法及用途
CN101297889B (zh) 治疗口蹄疫的中药制剂及其制备方法
CN102302161B (zh) 一种蛇肉肽口服液的制造方法
CN106118948A (zh) 一种辣木功能保健酒及其制备方法
CN101392218A (zh) 用天然蜂蜜和中草药酿制的营养保健酒及其制备方法
CN1094302A (zh) 一种纯中药口服液
WO2020037853A1 (zh) 一种促进微循环、提高人体机能的组合物及其制法
CN112370516A (zh) 一种具有活性成分的破壁灵芝孢子粉制品及其制备方法
CN107212392A (zh) 一种全营养发酵养生食品及其制备方法
CN101513445A (zh) 海马保健养生液及其制备方法
CN103212016A (zh) 一种治疗糖尿病伤口的活性生物酶提取液
CN115005436A (zh) 一种白芸豆发酵提取物及其制备方法和降糖降压的用途
CN108018326A (zh) 新型微生物蛋白酶水解制备东海乌参胶原蛋白肽
CN108048513A (zh) 一种胶原蛋白酶联合新型微生物蛋白酶水解制备乌参胶原蛋白低聚肽的方法
CN106820158A (zh) 能引钙入骨且防止骨钙流失的补钙复剂及其制备方法
CN109385356A (zh) 一种含有蚕蛹虫草子实体的碱性养生保健酒的制备方法
CN111763267A (zh) 一种山药多糖及蛋白的提取方法
CN111150056A (zh) 一种诺丽肽酵素及其制备方法和应用
CN106085682A (zh) Sod葡萄酒的制备方法
CN110393246A (zh) 一种有助于男性健康的牡蛎饮品生产方法
CN108464506A (zh) 三酶一酵富微生物液的生产方法
CN102823867A (zh) 一种能够修复受损胰岛细胞功能化的保健食品
CN1179328A (zh) 一种治疗糖尿病的药剂、食品及制作方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18930924

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18930924

Country of ref document: EP

Kind code of ref document: A1