WO2020034613A1 - 一种生化分析仪 - Google Patents

一种生化分析仪 Download PDF

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Publication number
WO2020034613A1
WO2020034613A1 PCT/CN2019/075425 CN2019075425W WO2020034613A1 WO 2020034613 A1 WO2020034613 A1 WO 2020034613A1 CN 2019075425 W CN2019075425 W CN 2019075425W WO 2020034613 A1 WO2020034613 A1 WO 2020034613A1
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WO
WIPO (PCT)
Prior art keywords
sample
incubation
detection
sampling
biochemical analyzer
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Application number
PCT/CN2019/075425
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English (en)
French (fr)
Inventor
罗继全
梁庆琳
李昆鹏
Original Assignee
三诺生物传感股份有限公司
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Application filed by 三诺生物传感股份有限公司 filed Critical 三诺生物传感股份有限公司
Publication of WO2020034613A1 publication Critical patent/WO2020034613A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids

Definitions

  • the present invention relates to the field of medical devices, and more particularly, to a biochemical analyzer.
  • a biochemical analyzer belongs to a type of clinical biochemical and pathological testing equipment.
  • the biochemical analyzer mainly provides doctors with relevant parameters of clinical biochemistry, clinical hematology, clinical immunology and other items, so as to cooperate with the patient's liver function, kidney Examination of clinical biochemical indicators such as work function, blood lipids, myocardial enzyme spectrum, protein, etc., provides an important scientific basis for physicians in the diagnosis, treatment, and prevention of diseases, and it is also an indispensable inspection equipment for clinical diagnosis work in hospitals.
  • biochemical analyzers have been widely used in various large and medium-sized hospitals, providing essential information basis for clinical diagnosis, treatment, prognosis and health status of diseases, becoming a major Indispensable standard equipment for mid-sized hospitals.
  • the technical problem to be solved by the present invention is to provide a biochemical analyzer, which, through its structural design, can fully automate sample detection and greatly improve the convenience of detection.
  • a biochemical analyzer includes a base, and a sample sending mechanism is provided above the base, the sample sending mechanism is used for transferring a sample to be detected, and an incubation mechanism is provided in a transfer direction of the sample sending mechanism.
  • the incubation mechanism is used for incubation heating of the sample to be detected, a sampling mechanism is provided behind the incubation mechanism, the sampling mechanism is used for aspiration and processing of the sample to be detected, and a detection mechanism is provided behind the sampling mechanism, The detection mechanism is used for the detection of the sample.
  • a casing is provided above the base, and the casing is disposed on the incubation mechanism and the sampling Agency, said testing agency.
  • the sample feeding mechanism includes a motor, a screw rod, and a slide table, and a horizontally arranged screw rod is connected to the motor, and the screw rod is connected to the slider that can be moved along the screw rod.
  • a reagent card is provided on the sample sending mechanism, the reagent card includes a card body, and the card body is provided with a sample cavity, a sampling needle holder, a cleaning cavity, a reagent cavity, and a detection cavity, and the A sample cavity is used for carrying the sample to be tested, the sampling needle holder is used for carrying the sampling needle, the cleaning cavity is used for cleaning the sampling needle, the reagent cavity is used for storing reagents required for sample detection, and The detection chamber is used for the mixing and detection of samples and reagents.
  • the incubation mechanism includes a bottom plate, a first heating plate is provided on the left side above the bottom plate, a second heating plate is provided on the right side above the bottom plate, and the first heating plate and the second heating plate A cover plate is provided above the heating plate, and an incubation cavity is formed around the bottom plate, the first heating plate, the second heating plate, and the cover plate, a fan is disposed in the incubation cavity, and a front end of the incubation cavity is formed.
  • the back end is provided with a channel port for installing the sample feeding mechanism to facilitate the in and out of the sample to be incubated.
  • the sampling mechanism includes a support frame provided above the sample feeding mechanism, a positioning block is provided on the support frame, a suction head is provided at the positioning block, and a rear end of the suction head is connected to A suction nozzle, a suction pipe is connected behind the suction nozzle, and a micro pump is connected behind the suction pipe.
  • a capping mechanism is provided at the sampling mechanism, the capping mechanism is used to separate the suction head from the suction nozzle, the capping mechanism includes a positioning plate, and a bayonet is provided on the positioning plate, A cap removing clip is provided in the bayonet, the cap removing clip is used for clamping and fixing the suction head to be separated, a horizontal movement component is provided behind the cap removing clip, and the horizontal movement component is used to drive the cap removing clip to walk in a horizontal direction, A vertical movement component is provided in front of the unclamping clip, and the vertical movement component is used to drive the suction nozzle to be separated to walk in the up-down direction.
  • a fixing frame is provided behind the positioning plate, the cap removing clip is embedded in the fixing frame, and a return spring is provided between the positioning plate and the fixing frame.
  • the beneficial effects of the present invention are:
  • the biochemical analyzer provided by the present invention realizes the sample to be detected through a sample sending mechanism. Transfer, and then use the incubation mechanism for the incubation heating of the sample to be tested, and then use the sampling mechanism for the aspiration and processing of the sample to be tested, and finally realize the sample detection through the detection mechanism, so that the full automation of sample detection can greatly improve Convenience of detection.
  • FIG. 1 is a schematic diagram of the overall structure of a biochemical analyzer disclosed in Embodiment 1 of the present invention.
  • FIG. 2 is a schematic explosion diagram of a biochemical analyzer disclosed in Embodiment 1 of the present invention.
  • Embodiment 3 is a schematic structural diagram of a sample sending mechanism disclosed in Embodiment 2 of the present invention.
  • FIG. 4 is a front view of a reagent card disclosed in Embodiment 3 of the present invention.
  • FIG. 5 is a plan view of a reagent card disclosed in Embodiment 3 of the present invention.
  • FIG. 6 is a schematic diagram of an overall structure of an incubation mechanism disclosed in Embodiment 4 of the present invention.
  • Embodiment 7 is a schematic explosion diagram of an incubation mechanism disclosed in Embodiment 4 of the present invention.
  • Embodiment 8 is a schematic structural diagram of a sampling mechanism disclosed in Embodiment 5 of the present invention.
  • FIG. 9 is an exploded view of a cap removing mechanism disclosed in Embodiment 6 of the present invention.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • FIG. 1 and FIG. 2 provide a specific embodiment of a biochemical analyzer of the present invention, wherein FIG. 1 is a schematic diagram of the overall structure of the biochemical analyzer disclosed in Embodiment 1 of the present invention; FIG. 2 is an explosion diagram of the biochemical analyzer disclosed in Embodiment 1 of the present invention.
  • the biochemical analyzer provided by the present invention includes a base 1, a sample feeding mechanism 2, an incubation mechanism 3, a sampling mechanism 4 and a detection mechanism 5.
  • the biochemical analyzer includes a base 1, and the base 1 is used for carrying components such as a sample feeding mechanism 2, an incubation mechanism 3, a sampling mechanism 4, a detection mechanism 5.
  • the specific shape of the base 1 is selected and designed according to actual needs.
  • a sample feeding mechanism 2 and a sample feeding mechanism 2 are provided above the base 1 for transmitting a sample to be detected.
  • the sample sending mechanism 2 not only transmits the sample to be detected, but also transmits reaction reagents and the like required for the detection process of the sample to be detected.
  • the samples and reagents are generally carried in a special reagent card 6.
  • An incubation mechanism 3 is provided in the transmission direction of the sample feeding mechanism 2.
  • the incubation mechanism 3 is used for incubation and heating of the sample to be detected.
  • the incubation mechanism 3 is provided to provide a predetermined constant temperature to the sample or reagent, thereby facilitating subsequent detection of the sample itself or reaction between the sample and the reagent.
  • a sampling mechanism 4 is provided behind the incubation mechanism 3, and the sampling mechanism 4 is used for aspiration and processing of the sample to be detected. Specifically, in the actual operation of the sampling mechanism 4, not only the sample books but also the reagents can be sucked, and the samples and reagents can also be sucked into the special detection chamber for reaction and detection. The specific sampling conditions of the sampling mechanism 4 are detected according to the needs of the samples. Project decision.
  • a detection mechanism 5 is provided behind the sampling mechanism 4, and the detection mechanism 5 is used to detect a sample.
  • the detection mechanism 5 can perform a sample detection using a colorimetric method or a transmission turbidimetry method.
  • a housing 8 is provided above the base 1, and the housing 8 covers the incubation Mechanism 3, the sampling mechanism 4, and the detection mechanism 5.
  • the sample sending mechanism 2 generally runs through the inside and outside of the casing 8, so that an external sample is sent into the casing 8 for testing.
  • the biochemical analyzer provided by the present invention realizes the transmission of the sample to be detected by the sample sending mechanism 2, and then uses the incubation mechanism 3 for the incubation heating of the sample to be detected, and then uses the sampling mechanism 4 for the to be detected.
  • the aspiration and processing of the sample, and finally the detection of the sample by the detection mechanism 5 can fully automate the detection of the sample and greatly improve the convenience of detection.
  • FIG. 3 provides a specific embodiment of a sample sending mechanism, wherein FIG. 3 is a schematic structural diagram of a sample sending mechanism disclosed in Embodiment 1 of the present invention.
  • the sample feeding mechanism 2 includes a motor 201, a screw rod 202, and a slide table 203.
  • the motor 201 is connected with a horizontally arranged screw rod 202, and the screw rod 202
  • the sliding table 203 is connected with the sliding table 203, and the sliding table 203 is used for supporting and fixing the external loading container.
  • the motor 201 is used to provide power for the rotation of the screw rod 202, so that the screw rod 202 can drive the slide table 202 to slide along the screw rod 202, and the slide table 203 can further move the loading container arranged above it. .
  • a linear axis is provided on both sides of the screw rod 202 at a horizontal interval, and a linear bearing is provided on the slide table 203.
  • the linear shaft is inserted into the linear bearing.
  • the slide table 203 is provided with a fixing frame, which is used for fixing the external sample loading container.
  • FIG. 4 and FIG. 5 provide a specific embodiment of a reagent card, wherein FIG. 4 is a front view of the reagent card disclosed in Embodiment 3 of the present invention; FIG. 5 is the present invention A plan view of a reagent card disclosed in Example 3.
  • the samples and reagents are often stored in a special container, and this embodiment provides a reagent card specifically for storing samples and reagents.
  • the reagent card is generally installed on the slide table described in Embodiment 2.
  • the reagent card 6 provided in this embodiment includes a card body 601.
  • the card body 601 is provided with a sample cavity 602, a sampling needle holder 603, a cleaning cavity 604, a reagent cavity 605, and a detection cavity 606.
  • the sampling needle holder 603 is used for the loading of the sampling needle 607
  • the cleaning chamber 604 is used for cleaning the sampling needle 607
  • the reagent chamber 605 is used for storing reagents required for sample detection
  • the detection chamber 606 is used for mixing and detecting a sample and a reagent.
  • the sampling needle 607 can generally be matched and connected with the sampling mechanism 4.
  • the sample cavity 602, the sampling needle holder 603, the cleaning cavity 604, the reagent cavity 605, and the detection cavity 606 are mutually The specific arrangement is to facilitate operation.
  • the card body 601 is sequentially arranged with a sample cavity 602 from a left end to a right end, a sample cavity 602, a cleaning cavity 604, a sampling needle holder 603, a cleaning cavity 604, and four reagent cavities 605 (each reagent cavity 605 generally stores different reagents)
  • Four detection chambers 606 (each detection chamber 606-generally used for mixed detection of different reagents).
  • other arrangements can also be used.
  • the sample cavity 602 is used for carrying a sample to be detected.
  • the sample cavity 602 provided in this embodiment is preferably a funnel-shaped sample cavity.
  • the sampling needle holder 603 is used for carrying the sampling needle 607.
  • the interface above the sampling needle 607 is generally provided with an interface that matches the tip of an external fully automatic biochemical analyzer.
  • the tip of the fully automatic biochemical analyzer can be used. Suck the sampling needle 607 directly to move the sample cavity 602, the cleaning cavity 604, the reagent cavity 605, and the detection cavity 606 to perform the sample detection operation.
  • the cleaning chamber 604 is used to store a cleaning liquid to facilitate the cleaning of the sampling needle 607, so that the sampling needle 607 can be cleaned every time a sample is taken or a reagent is sucked, effectively avoiding the influence of mutual interference between different reagents.
  • the drawings provided in this embodiment are provided with a cleaning chamber 604 at the left and right ends of the sampling needle holder 603.
  • the reagent chamber 605 is used for storing reagents required for sample detection. Specifically, in this embodiment, a total of four reagent chambers 605 are designed, where each reagent chamber 605 can store different reagents.
  • the detection cavity 606 is used for mixing and detecting a sample and a reagent. Specifically, in this embodiment, a total of four detection cavities 606 are designed, and each of the detection cavities 606 can be used to detect different index parameters of the sample.
  • the reagent card provided by the present invention carries the sample to be tested through the sample cavity 602 and the reagent cavity 605 to store the reagents required for sample detection, and then uses the sampling needle 607 on the sampling needle holder 603 to aspirate the sample books and reagents. Mix and test in the detection chamber 606, and clean the sampling needle 607 every time the sample needle or reagent is aspirated through the cleaning chamber 604, so as to facilitate the addition of reagents, effectively realize the detection of various parameters of the sample, and improve the detection efficiency.
  • FIG. 6 and FIG. 7 provide a specific embodiment of the incubation mechanism, wherein FIG. 6 is a schematic diagram of the overall structure of the incubation mechanism disclosed in Embodiment 4 of the present invention; FIG. 7 is Explosion diagram of the incubation mechanism disclosed in Invention Example 4. As shown in FIGS.
  • the incubation mechanism 3 provided in this embodiment includes a bottom plate 301, a first heating plate 302 is provided on the left side above the bottom plate 301, and a second plate is provided on the right side above the bottom plate 301
  • a heating plate 303, a cover plate 304 is provided above the first heating plate 302 and the second heating plate 30303, the bottom plate 301, the first heating plate 302, the second heating plate 303, and the cover
  • An incubation cavity is formed around the plate 304, and a fan 305 is disposed in the incubation cavity.
  • a front or rear end of the incubation cavity 305 is provided with a channel opening 306 for installing the sample feeding mechanism 2 to facilitate the ingress and egress of the sample to be incubated.
  • the incubation mechanism includes a bottom plate 301, a first heating plate 302, a second heating plate 303, a cover plate 304, a fan 305, and a passage opening 306.
  • the bottom plate 301, the first heating plate 302, the second heating plate 303, and the cover plate 304 surround an incubation cavity, and the incubation cavity is used to provide an incubation space for the sample to be detected.
  • the bottom plate 301 is used for supporting, and the specific structural shape of the bottom plate 301 is selected and designed according to actual needs.
  • a first heating plate 302 is provided on the left side above the bottom plate 301, and a second heating plate 303 is provided on the right side above the bottom plate 301.
  • the first heating plate 302 and the second heating plate 303 are provided from the left and right sides.
  • the incubation chamber emits the heat needed to incubate the sample to be tested. Specifically, it is generally necessary to ensure that the sample temperature reaches 37.5 degrees.
  • a cover plate 304 is provided above the first heating plate 302 and the second heating plate 303, and the cover plate 304 is used for sealing and protecting.
  • a fan 305 is provided in the incubation chamber, and the fan 305 is used to supply air to the incubation chamber, thereby enhancing the air flow speed in the incubation chamber and accelerating the temperature rising rate of the sample to be detected.
  • the front or rear end of the incubation chamber is provided with a channel opening 306 for the in and out of the sample to be incubated.
  • the first heating plate 302 and the second heating plate 303 will simultaneously provide heat to the sample from the left and right sides, and at the same time, the fan 305 sends air to the inside of the incubation chamber.
  • the air flow is accelerated, so that samples at different heights can be heated at the same time, which can not only improve the heating efficiency, but also effectively ensure the heating quality.
  • the air supply direction of the fan 305 is the front-back direction.
  • FIG. 8 provides a specific embodiment of a sampling mechanism, wherein FIG. 8 is Embodiment 5 of the present invention. Schematic diagram of the disclosed sampling mechanism.
  • the sampling mechanism 4 provided in this embodiment includes a support frame 401 provided above the sample sending mechanism, and a positioning block 402 is provided on the support frame 401, and the positioning block 402 is provided at the position There is a suction head 403, a suction nozzle 404 is connected behind the suction head 403, a suction pipe 405 is connected behind the suction nozzle 404, and a micro pump 406 is connected behind the suction pipe 405.
  • the positioning block 402 is used for monitoring the position of the sample to be detected, so as to accurately monitor the position of the sample to be detected, and ensure that the sample loading container can be moved directly below the tip 403.
  • the tip 403 is used to suck the reagent or the sample or the mixed solution of the reagent and the sample, and the micro pump 406 is used to provide the power required for the suction and control the suction amount.
  • the sample loading container loaded with the sample to be tested is fixed on the sample sending mechanism 2, and the sample sending mechanism 2 starts the sample sending, thereby transferring the sample loading container to the position where the tip 403 is located;
  • the vacuum force provided by the micro-pump 406 is transmitted to the suction head 403, and the suction head 403 can transfer the sample and reagent in the loading container to a special test cup for mixing;
  • the tip 403 sends the mixed liquid into the test channel for testing.
  • the sample sending mechanism 2 sends the sample container out, so that the entire workflow can be automated.
  • Embodiment 6 is a diagrammatic representation of Embodiment 6
  • FIG. 9 provides a specific embodiment of a cap removing mechanism, wherein FIG. 9 is an exploded schematic view of the cap removing mechanism disclosed in Embodiment 6 of the present invention.
  • the sampling mechanism 4 provided in this embodiment is provided with a cap removing mechanism 7, the cap removing mechanism 7 is used to separate the suction head and the suction nozzle described in Embodiment 5, the cap removing mechanism 7 includes a positioning plate 701, a bayonet 702 is provided on the positioning plate 701, and a cap-off clip 703 is provided in the bayonet 702, the cap-off clip 703 is used for clamping and fixing the suction head to be separated, and the cap-off clip A horizontal movement component 704 is provided at the rear of 703, and the horizontal movement component 704 is used to drive the cap removing clip 703 to walk in a horizontal direction. A vertical movement component 705 is provided in front of the cap removing clip 703, and the vertical movement component 705 is used to drive The nozzle to be separated walks up and down.
  • the positioning plate 701 in this embodiment may be the same component as the positioning block 402 in Embodiment 5, or may be a different component.
  • the cap removing mechanism provided by the embodiment of the present invention includes a positioning plate 701, a bayonet 702, a cap removing clip 703, a horizontal movement component 704, and a vertical movement component 705.
  • the positioning plate 701 is used to provide positioning for separating the suction head from the suction nozzle. That is, a predetermined position is provided for the separation of the suction head from the suction nozzle. When the suction head and the suction nozzle are moved to this position, the system starts the separation work of the suction head from the suction nozzle.
  • the positioning plate 701 is provided with a bayonet 702, and the bayonet 702 is provided with a cap removing clip 703, and the cap removing clip 70 3 is used for clamping and fixing the tip to be separated.
  • a horizontal movement component 704 is disposed behind the cap removing clip 703, and the horizontal movement component 704 is used to drive the cap removing clip 703 to walk in a horizontal direction.
  • the orientation word used in this embodiment is the left side of the drawing.
  • a vertical movement component 705 is provided in front of the unclamping clip 703, and the vertical movement component 705 is used to drive the suction nozzle 7 to travel in the up-down direction.
  • the front of the orientation word used in this embodiment is the right side of the drawing.
  • the horizontal movement component 704 drives the cap removing clip 703 to move horizontally along the bayonet 702 until the jaw of the cap removing clip 703 is caught.
  • the suction head, and then the vertical movement component 705 drives the suction nozzle to walk upwards.
  • the suction nozzle is separated from the suction head when it is moved upward by the vertical movement component 705.
  • the suction head described in this embodiment is generally small on the upper head and large on the lower head, and the grip of the unclip clip 703 described in this embodiment is a U-shaped grip.
  • the cap removing clips 703 are provided with at least two.
  • the drawing provided in this embodiment is provided with two cap removing clips 703.
  • a fixing frame 706 is provided behind the positioning plate 701, and the cap removing clip 703 is embedded in the fixing frame.
  • a position is provided between the positioning plate 701 and the fixing frame 706. Return spring 707.
  • a code scanner is provided between the horizontal movement component 704 and the cap removing clip 703, and the code scanner is used for identifying the information of the tip to be separated.
  • a sealing film is generally provided above.
  • a rupture needle is provided on the straight movement component 705.

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Abstract

一种生化分析仪，包括基座（1），所述基座（1）上方设置有送样机构（2），所述送样机构（2）用于待检测样本的传输，该送样机构（2）的传输方向上设置有孵育机构（3），所述孵育机构（3）用于待检测样本的孵育加热，所述孵育机构（3）后方设置有取样机构（4），所述取样机构（4）用于待检测样本的吸取与处理，所述取样机构（4）后方设置有检测机构（5），所述检测机构（5）用于样本的检测。该生化分析仪通过送样机构实现待检测样本的传输，然后利用孵育机构用于待检测样本的孵育加热，再通过取样机构用于待检测样本的吸取与处理，最后通过检测机构实现样本的检测，从而能够样本检测的全自动化，极大提高检测的便利性。

Description

一种生化分析仪
技术领域
[0001] 本发明涉及医疗器械领域， 更具体地说， 特别涉及一种生化分析仪。
背景技术
[0002] 生化分析仪属于一种临床生化与病理检验设备， 生化分析仪主要是为医师提供 临床生化学、 临床血液学、 临床免疫学等项目的相关参数， 从而配合用于患者 肝功、 肾功、 血脂、 心肌酶谱、 蛋白质等临床生化指标的检验， 为医师在疾病 的诊断、 治疗、 预防中提供重要的科学依据， 也是医院开展临床诊断工作必备 的检验设备。 目前， 生化分析仪作为临床检验中经常使用的重要仪器之一， 已 普遍使用于各个大中型医院， 给临床上对疾病的诊断、 治疗和预后及健康状态 提供必不可少的信息依据， 成为大中型医院不可或缺的标配仪器。
[0003] 实际操作中， 由于现有的生化分析仪结构设计上存在局限性， 导致现有的生化 分析仪的自动化程度往往不高， 很多操作流程都需要工作人员手工操作， 给检 测工作带来了极大的不便。
发明概述
技术问题
问题的解决方案
技术解决方案
[0004] 本发明要解决的技术问题为提供一种生化分析仪， 该生化分析仪通过其结构设 计， 能够样本检测的全自动化， 极大提高检测的便利性。
[0005] 一种生化分析仪， 包括基座， 所述基座上方设置有送样机构， 所述送样机构用 于待检测样本的传输， 所述送样机构的传输方向上设置有孵育机构， 所述孵育 机构用于待检测样本的孵育加热， 所述孵育机构后方设置有取样机构， 所述取 样机构用于待检测样本的吸取与处理， 所述取样机构后方设置有检测机构， 所 述检测机构用于样本的检测。
[0006] 优选地， 所述基座上方设置有外壳， 所述外壳罩设在所述孵育机构、 所述取样 机构、 所述检测机构上。
[0007] 优选地， 所述送样机构包括电机、 丝杆、 滑台， 所述电机上连接有水平布置的 丝杆， 所述丝杆上连接有可沿所述丝杆移动的所述滑台， 所述滑台用于外部装 样容器的支撑固定。
[0008] 优选地， 所述送样机构上设置有试剂卡， 所述试剂卡包括卡体， 所述卡体上设 置有样本腔、 取样针支架、 清洗腔、 试剂腔、 检测腔， 所述样本腔用于待检测 样本的承载， 所述取样针支架用于取样针的承载， 所述清洗腔用于取样针的清 洗， 所述试剂腔用于样本检测中所需试剂的存储， 所述检测腔用于样本与试剂 的混合及检测。
[0009] 优选地， 所述孵育机构包括底板， 所述底板上方左侧设置有第一加热板， 所述 底板上方右侧设置有第二加热板， 所述第一加热板与所述第二加热板上方设置 有盖板， 所述底板、 所述第一加热板、 所述第二加热板及所述盖板围绕形成有 孵育腔， 所述孵育腔内设置有风扇， 所述孵育腔前端或后端设置有用于安装所 述送样机构以方便待孵育样本进出的通道口。
[0010] 优选地， 所述取样机构包括设置于所述送样机构上方的支撑架， 所述支撑架上 设置有定位块， 所述定位块处设置有吸头， 所述吸头后方连接有吸嘴， 所述吸 嘴后方连接有吸管， 所述吸管后方连接有微量泵。
[0011] 优选地， 所述取样机构处设置有脱帽机构， 所述脱帽机构用于吸头与吸嘴的分 离， 所述脱帽机构包括定位板， 所述定位板上设置有卡口， 所述卡口内设置有 脱帽夹， 所述脱帽夹用于待分离吸头的夹持固定， 所述脱帽夹后方设置有水平 运动组件， 所述水平运动组件用于带动所述脱帽夹沿水平方向行走， 所述脱帽 夹前方设置有垂直运动组件， 所述垂直运动组件用于带动待分离吸嘴沿上下方 向行走。
[0012] 优选地， 所述定位板后方设置有固定架， 所述脱帽夹嵌装在所述固定架内， 所 述定位板与所述固定架之间设置有复位弹簧。
发明的有益效果
有益效果
[0013] 本发明的有益效果是： 本发明提供的生化分析仪通过送样机构实现待检测样本 的传输， 然后利用孵育机构用于待检测样本的孵育加热， 再通过取样机构用于 待检测样本的吸取与处理， 最后通过检测机构实现样本的检测， 从而能够样本 检测的全自动化， 极大提高检测的便利性。
对附图的简要说明
附图说明
[0014] 为了更清楚地说明本发明实施例或现有技术中的技术方案， 下面将对实施例或 5见有技术描述中所需要使用的附图作简单地介绍， 显而易见地， 下面描述中的 附图仅仅是本发明的实施例， 对于本领域普通技术人员来讲， 在不付出创造性 劳动的前提下， 还可以根据提供的附图获得其他的附图。
[0015] 图 1为本发明实施例 1所公开的生化分析仪的整体结构示意图；
[0016] 图 2为本发明实施例 1所公开的生化分析仪的爆炸示意图；
[0017] 图 3为本发明实施例 2所公开的送样机构的结构示意图；
[0018] 图 4为本发明实施例 3所公开的试剂卡的主视图；
[0019] 图 5为本发明实施例 3所公开的试剂卡的俯视图；
[0020] 图 6为本发明实施例 4所公开的孵育机构的整体结构示意图；
[0021] 图 7为本发明实施例 4所公开的孵育机构的爆炸示意图；
[0022] 图 8为本发明实施例 5所公开的取样机构的结构示意图；
[0023] 图 9为本发明实施例 6所公开的脱帽机构的爆炸示意图。
实施该发明的最佳实施例
本发明的最佳实施方式
[0024] 为了使本技术领域的人员更好地理解本申请中的技术方案， 下面将结合本申请 实施例中的附图， 对本申请实施例中的技术方案进行清楚、 完整地描述， 显然 ， 所描述的实施例仅仅是本申请一部分实施例， 而不是全部的实施例。 基于本 申请中的实施例， 本领域普通技术人员在没有做出创造性劳动前提下所获得的 所有其他实施例， 都应当属于本申请保护的范围。
[0025] 在本发明的描述中， 需要理解的是， 术语“上方”、 “水平”、 “垂直”、 “前方”、 “ 后方”等指示的方位或位置关系为基于附图所示的方位或位置关系， 仅是为了便 于描述本发明和简化描述， 而不是指示或暗示所指的装置或元件必须具有特定 的方位、 以特定的方位构造和操作， 因此不能理解为对本发明的限制。
[0026] 实施例 1 :
[0027] 参见图 1和图 2, 图 1和图 2提供了本发明一种生化分析仪的具体实施例， 其中， 图 1为本发明实施例 1所公开的生化分析仪的整体结构示意图； 图 2为本发明实施 例 1所公开的生化分析仪的爆炸示意图。
[0028] 如图 1和图 2所示， 本发明提供的生化分析仪包括基座 1， 送样机构 2， 孵育机构 3， 取样机构 4和检测机构 5。
[0029] 本方案中， 该生化分析仪包括基座 1， 基座 1用于送样机构 2， 孵育机构 3， 取样 机构 4、 检测机构 5等部件的承载。 其中， 基座 1的具体形状根据实际需要进行选 择设计。
[0030] 基座 1上方设置有送样机构 2, 送样机构 2用于待检测样本的传输。 具体地， 送 样机构 2不仅仅传输待检测样本， 还会传输待检测样本检测过程所需的反应试剂 等。 其中， 样本与试剂一般承载在专门的试剂卡 6内。
[0031] 送样机构 2的传输方向上设置有孵育机构 3， 孵育机构 3用于待检测样本的孵育 加热。 具体地， 孵育机构 3的设置用于给样本或试剂提供一个规定的恒定的温度 ， 从而便于后续样本本身的检测或者样本与试剂的反应。
[0032] 孵育机构 3后方设置有取样机构 4， 所述取样机构 4用于待检测样本的吸取与处 理。 具体地， 取样机构 4实际操作中， 不仅仅可以吸取样本， 也可以吸取试剂， 还可以将样本与试剂一起吸取至专门的检测腔进行反应和检测， 取样机构 4的具 体取样情况根据样本需检测的项目决定。
[0033] 取样机构 4后方设置有检测机构 5， 所述检测机构 5用于样本的检测。 其中， 检 测机构 5可以利用比色法或透射比浊法来进行样本检测。
[0034] 本实施例中， 为进一步实现机构的安全范围， 同时防止外部物质污染样本或试 齐 1 优选地， 所述基座 1上方设置有外壳 8 , 所述外壳 8罩设在所述孵育机构 3、 所述取样机构 4、 所述检测机构 5上。 其中， 送样机构 2—般贯穿外壳 8内外， 从 而将外部的样本送入至外壳 8内进行检测。
[0035] 整体而言， 本发明提供的生化分析仪通过送样机构 2实现待检测样本的传输， 然后利用孵育机构 3用于待检测样本的孵育加热， 再通过取样机构 4用于待检测 样本的吸取与处理， 最后通过检测机构 5实现样本的检测， 从而能够样本检测的 全自动化， 极大提高检测的便利性。
[0036] 实施例 2:
[0037] 参见图 3， 图 3提供了一种送样机构的具体实施例， 其中， 图 3为本发明实施例 1 所公开的送样机构的结构示意图。
[0038] 如图 3所示， 本实施例提供的该送样机构 2包括电机 201、 丝杆 202、 滑台 203， 所述电机 201上连接有水平布置的丝杆 202, 所述丝杆 202上连接有可沿所述丝杆 202移动的所述滑台 203 , 所述滑台 203用于外部装样容器的支撑固定。
[0039] 具体地， 电机 201用于给丝杆 202的旋转提供动力， 丝杆 202从而可以带动滑台 2 03沿着丝杆 202滑动， 滑台 203进而能带动其上方布置的装样容器移动。
[0040] 本实施例中， 为进一步实现装样容器在水平方向上的稳定传输， 优选地， 所述 丝杆 202两侧水平间隔设置有直线轴， 所述滑台 203上设置有直线轴承， 所述直 线轴插设在所述直线轴承内。
[0041] 本实施例中， 为进一步方便装样容器的支撑固定， 优选地， 所述滑台 203上设 置有固定架， 所述固定架用于外部装样容器的固定。
[0042] 实施例 3:
[0043] 参见图 4和图 5， 图 4和图 5提供了一种试剂卡的具体实施例， 其中， 图 4为本发 明实施例 3所公开的试剂卡的主视图； 图 5为本发明实施例 3所公开的试剂卡的俯 视图。
[0044] 具体实施过程中， 为方便样本与试剂进出生化分析仪， 样本与试剂往往储存在 专门的容器内， 本实施例即提供了一种专门储存样本与试剂的试剂卡。
[0045] 本实施例中， 该试剂卡一般安装在实施例 2所描述的滑台上。 本实施例提供的 试剂卡 6包括卡体 601， 所述卡体 601上设置有样本腔 602、 取样针支架 603、 清洗 腔 604、 试剂腔 605、 检测腔 606 , 所述样本腔 602用于待检测样本的承载， 所述 取样针支架 603用于取样针 607的承载， 所述清洗腔 604用于取样针 607的清洗， 所述试剂腔 605用于样本检测中所需试剂的存储， 所述检测腔 606用于样本与试 剂的混合及检测。 其中， 取样针 607—般可以与取样机构 4相匹配连接。
[0046] 对于样本腔 602、 取样针支架 603、 清洗腔 604、 试剂腔 605、 检测腔 606相互之 间具体的排列方式， 以方便操作为准。 本实施例提供的附图中， 卡体 601从左端 到右端依次排列有样本腔 602 清洗腔 604 取样针支架 603 清洗腔 604 四个试 剂腔 605 （每个试剂腔 605—般存储不同的试剂） 四个检测腔 606 （每个检测腔 606—般用于不同试剂的混合检测） 。 当然， 也可以采用其他排列方式。
[0047] 本方案中， 样本腔 602用于待检测样本的承载。 为进一步方便样本的承载与吸 取， 本实施例提供的样本腔 602优选为漏斗状样本腔。
[0048] 本方案中， 取样针支架 603用于取样针 607的承载。 具体地， 取样针 607的上方 一般设置有与外部全自动生化分析仪的吸头相匹配的接口， 如此， 当试剂卡被 推进全自动生化分析仪内部后， 全自动生化分析仪吸头便可以直接吸住取样针 6 07动作， 从而在样本腔 602、 清洗腔 604、 试剂腔 605、 检测腔 606各处移动以进 行样本的检测操作。
[0049] 本方案中， 清洗腔 604用于存储清洗液从而方便取样针 607的清洗， 从而可以在 取样针 607每次取样或吸取试剂时都进行清洗， 有效避免不同试剂间的相互干涉 影响。 为进一步方便取样针 607的清洗， 本实施例提供的附图在取样针支架 603 的左右两端均设置了一个清洗腔 604。
[0050] 本方案中， 试剂腔 605用于样本检测中所需试剂的存储。 具体地， 本实施例共 设计了四个试剂腔 605， 其中每个试剂腔 605可以存储不同的试剂。
[0051] 本方案中， 检测腔 606用于样本与试剂的混合及检测。 具体地， 本实施例共设 计了四个检测腔 606 , 其中每个检测腔 606可以用于样本不同指标参数的检测。
[0052] 整体而言， 本实用新型提供的该试剂卡通过样本腔 602承载待检测样本及试剂 腔 605存储样本检测中所需试剂， 然后利用取样针支架 603上的取样针 607吸取样 本与试剂至检测腔 606进行混合及检测， 同时通过清洗腔 604对取样针 607每次吸 取样本或试剂前进行清洗， 从而能够方便试剂的添加， 有效实现样本各项不同 参数的检测， 提高检测效率。
[0053] 实施例 4:
[0054] 参见图 6和图 7， 图 6和图 7提供了孵育机构的一种具体实施例， 其中， 图 6为本 发明实施例 4所公开的孵育机构的整体结构示意图； 图 7为本发明实施例 4所公开 的孵育机构的爆炸示意图。 [0055] 如图 6和如 7所示， 本实施例提供的孵育机构 3包括底板 301， 所述底板 301上方 左侧设置有第一加热板 302， 所述底板 301上方右侧设置有第二加热板 303， 所述 第一加热板 302与所述第二加热板 30303上方设置有盖板 304， 所述底板 301、 所 述第一加热板 302、 所述第二加热板 303及所述盖板 304围绕形成有孵育腔， 所述 孵育腔内设置有风扇 305 , 所述孵育腔 305前端或后端设置有用于安装所述送样 机构 2以方便待孵育样本进出的通道口 306。
[0056] 具体地， 本实施例提供的该孵育机构包括底板 301， 第一加热板 302， 第二加热 板 303， 盖板 304， 风扇 305和通道口 306。
[0057] 本方案中， 底板 301、 所述第一加热板 302、 所述第二加热板 303及所述盖板 304 围绕形成有孵育腔， 孵育腔用于给待检测样本提供孵育的空间。
[0058] 底板 301用于起支撑作用， 底板 301的具体结构形状根据实际需要进行选择设计
[0059] 底板 301上方左侧设置有第一加热板 302， 所述底板 301上方右侧设置有第二加 热板 303 第一加热板 302和第二加热板 303用于从左侧和右侧向孵育腔散发待检 测样本孵育所需的热量。 具体地， 一般需保证样本温度达到 37.5度。
[0060] 第一加热板 302与所述第二加热板 303上方设置有盖板 304， 盖板 304用于起密封 作用与防护作用。
[0061] 孵育腔内设置有风扇 305 , 风扇 305用于给孵育腔送风， 从而增强孵育腔内的空 气流动速度， 加快待检测样本的升温速度。
[0062] 孵育腔前端或后端设置有用于待孵育样本进出的通道口 306。
[0063] 本实施例提供的该孵育机构具体实施过程中， 第一加热板 302和第二加热板 303 会从左侧和右侧同时向样本提供热量， 同时风扇 305送风会使孵育腔内空气流动 加速， 从而可以使各个高度的样本同时受热， 从而既能提高加热效率， 又能有 效确保加热质量。
[0064] 本实施例中， 为进一步保证孵育腔内各部分温度的均衡性， 优选地， 所述风扇 305的送风方向为前后方向。
[0065] 实施例 5:
[0066] 参见图 8， 图 8提供了取样机构的一种具体实施例， 其中， 图 8为本发明实施例 5 所公开的取样机构的结构示意图。
[0067] 如图 8所示， 本实施例提供的取样机构 4包括设置于所述送样机构上方的支撑架 401 , 所述支撑架 401上设置有定位块 402， 所述定位块 402处设置有吸头 403， 所 述吸头 403后方连接有吸嘴 404, 所述吸嘴 404后方连接有吸管 405 , 所述吸管 405 后方连接有微量泵 406。
[0068] 具体地， 定位块 402用于待检测样本位置的监测， 从而准确监测待检测样本所 处的位置， 确保装样容器可以移动到吸头 403正下方。 吸头 403用于吸取试剂或 样本或试剂与样本的混合液， 微量泵 406用于提供吸取所需的动力， 控制吸取量
[0069] 具体实施过程中：
[0070] 首先， 将装载有待检测样本的装样容器固定在送样机构 2上， 送样机构 2启动送 样， 从而将装样容器传输至吸头 403所处的位置处；
[0071] 然后， 微量泵 406提供的真空力传到吸头 403 , 吸头 403便可以把装样容器里面 的样本和试剂吸取转移到专门的测试杯中进行混合；
[0072] 最后， 吸头 403再将混合液送入测试通道中测试， 待测试完成以后送样机构 2将 装样容器送出， 从而即可实现整个工作流程的自动化操作。
[0073] 实施例 6:
[0074] 参见图 9， 图 9提供了一种脱帽机构的具体实施例， 其中， 图 9为本发明实施例 6 所公开的脱帽机构的爆炸示意图。
[0075] 如图 9所示， 本实施例提供的取样机构 4处设置有脱帽机构 7， 所述脱帽机构 7用 于实施例 5中所描述的吸头与吸嘴的分离， 所述脱帽机构 7包括定位板 701， 所述 定位板 701上设置有卡口 702, 所述卡口 702内设置有脱帽夹 703 , 所述脱帽夹 703 用于待分离吸头的夹持固定， 所述脱帽夹 703后方设置有水平运动组件 704, 所 述水平运动组件 704用于带动所述脱帽夹 703沿水平方向行走， 所述脱帽夹 703前 方设置有垂直运动组件 705， 所述垂直运动组件 705用于带动待分离吸嘴沿上下 方向行走。
[0076] 此外， 本实施例中的定位板 701可以与实施例 5中的定位块 402为同一部件， 也 可以为不同的部件。 [0077] 具体地， 本实用新型实施例提供的脱帽机构包括定位板 701， 卡口 702， 脱帽夹 703 , 水平运动组件 704， 垂直运动组件 705。
[0078] 本实施例中， 定位板 701用于给吸头与吸嘴的分离提供定位。 也就是说， 给吸 头与吸嘴的分离提供一个规定的位置， 当吸头与吸嘴移动到该位置时， 系统启 动吸头与吸嘴的分离工作。
[0079] 定位板 701上设置有卡口 702, 所述卡口 702内设置有脱帽夹 703 , 所述脱帽夹 70 3用于待分离吸头的夹持固定。
[0080] 脱帽夹 703后方设置有水平运动组件 704， 所述水平运动组件 704用于带动所述 脱帽夹 703沿水平方向行走。 具体地， 本实施例所用的方位词后方为附图的左侧
[0081] 脱帽夹 703前方设置有垂直运动组件 705 , 所述垂直运动组件 705用于带动待分 离吸嘴 7沿上下方向行走。 具体地， 本实施例所用的方位词前方为附图的右侧。
[0082] 具体实施过程中， 当吸头与吸嘴的组装件移动到定位板 701处时， 水平运动组 件 704带动脱帽夹 703沿卡口 702呈水平运动， 直至脱帽夹 703的夹口卡住吸头， 然后垂直运动组件 705带动吸嘴向上行走， 该过程中， 由于吸头已被脱帽夹 703 夹住， 因此吸嘴被垂直运动组件 705带动向上运动时便会与吸头相分离。 具体地 ， 为进一步方便脱帽夹 703对吸头的卡夹， 本实施例所描述的吸头一般为上头小 下头大， 本实施例所描述的脱帽夹 703的夹口为 U形夹口。
[0083] 本实施例中， 为进一步方便多组吸头与吸嘴的同时分离， 优选地， 所述脱帽夹 703设置有至少两个。 本实施例提供的附图即设置有两个脱帽夹 703。
[0084] 本实施例中， 为进一步方便脱帽夹 703运动时的导向， 优选地， 所述定位板 701 后方设置有固定架 706 , 所述脱帽夹 703嵌装在所述固定架内。
[0085] 本实施例中， 为进一步方便脱帽夹 703完成吸头与吸嘴的分离操作后能及时回 复至原来的位置， 优选地， 所述定位板 701与所述固定架 706之间设置有复位弹 簧 707。
[0086] 本实施例中， 所述水平运动组件 704与所述脱帽夹 703之间设置有扫码器， 所述 扫码器用于待分离吸头信息的识别。
[0087] 此外， 考虑到有些样本承载容易上方一般会设置密封膜， 本实施例还可以在垂 直运动组件 705上设置破膜针。
[0088] 以上对本发明所提供的一种生化分析仪进行了详细介绍。 本文中应用了具体 个例对本发明的原理及实施方式进行了阐述， 以上实施例的说明只是用于帮助 理解本发明的方法及其核心思想。 应当指出， 对于本技术领域的普通技术人员 来说， 在不脱离本发明原理的前提下， 还可以对本发明进行若干改进和修饰， 这些改进和修饰也落入本发明权利要求的保护范围内。

Claims

权利要求书
[权利要求 1] 一种生化分析仪， 其特征在于， 包括基座， 所述基座上方设置有送样 机构， 所述送样机构用于待检测样本的传输， 所述送样机构的传输方 向上设置有孵育机构， 所述孵育机构用于待检测样本的孵育加热， 所 述孵育机构后方设置有取样机构， 所述取样机构用于待检测样本的吸 取与处理， 所述取样机构后方设置有检测机构， 所述检测机构用于样 本的检测。
[权利要求 2] 根据权利要求 1所述的生化分析仪， 其特征在于， 所述基座上方设置 有外壳， 所述外壳罩设在所述孵育机构、 所述取样机构、 所述检测机 构上。
[权利要求 3] 根据权利要求 1所述的生化分析仪， 其特征在于， 所述送样机构包括 电机、 丝杆、 滑台， 所述电机上连接有水平布置的所述丝杆， 所述丝 杆上连接有可沿所述丝杆移动的所述滑台， 所述滑台用于外部装样容 器的支撑固定。
[权利要求 4] 根据权利要求 1所述的生化分析仪， 其特征在于， 所述送样机构上设 置有试剂卡， 所述试剂卡包括卡体， 所述卡体上设置有样本腔、 取样 针支架、 清洗腔、 试剂腔、 检测腔， 所述样本腔用于待检测样本的承 载， 所述取样针支架用于取样针的承载， 所述清洗腔用于取样针的清 洗， 所述试剂腔用于样本检测中所需试剂的存储， 所述检测腔用于样 本与试剂的混合及检测。
[权利要求 5] 根据权利要求 1所述的生化分析仪， 其特征在于， 所述孵育机构包括 底板， 所述底板上方左侧设置有第一加热板， 所述底板上方右侧设置 有第二加热板， 所述第一加热板与所述第二加热板上方设置有盖板， 所述底板、 所述第一加热板、 所述第二加热板及所述盖板围绕形成有 孵育腔， 所述孵育腔内设置有风扇， 所述孵育腔前端或后端设置有用 于安装所述送样机构以方便待孵育样本进出的通道口。
[权利要求 6] 根据权利要求 1所述的生化分析仪， 其特征在于， 所述取样机构包括 设置于所述送样机构上方的支撑架， 所述支撑架上设置有定位块， 所 述定位块处设置有吸头， 所述吸头后方连接有吸嘴， 所述吸嘴后方连 接有吸管， 所述吸管后方连接有微量泵。
[权利要求 7] 根据权利要求 6所述的生化分析仪， 其特征在于， 所述取样机构处设 置有脱帽机构， 所述脱帽机构用于吸头与吸嘴的分离， 所述脱帽机构 包括定位板， 所述定位板上设置有卡口， 所述卡口内设置有脱帽夹， 所述脱帽夹用于待分离吸头的夹持固定， 所述脱帽夹后方设置有水平 运动组件， 所述水平运动组件用于带动所述脱帽夹沿水平方向行走， 所述脱帽夹前方设置有垂直运动组件， 所述垂直运动组件用于带动待 分离吸嘴沿上下方向行走。
[权利要求 8] 根据权利要求 7所述的生化分析仪， 其特征在于， 所述定位板后方设 置有固定架， 所述脱帽夹嵌装在所述固定架内， 所述定位板与所述固 定架之间设置有复位弹簧。
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