WO2019226599A1 - Diagnostics et traitements de sujets insensibles à un anesthésique - Google Patents

Diagnostics et traitements de sujets insensibles à un anesthésique Download PDF

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Publication number
WO2019226599A1
WO2019226599A1 PCT/US2019/033226 US2019033226W WO2019226599A1 WO 2019226599 A1 WO2019226599 A1 WO 2019226599A1 US 2019033226 W US2019033226 W US 2019033226W WO 2019226599 A1 WO2019226599 A1 WO 2019226599A1
Authority
WO
WIPO (PCT)
Prior art keywords
anesthetic
subject
location
formulation
potassium
Prior art date
Application number
PCT/US2019/033226
Other languages
English (en)
Inventor
Michael M. Segal
Original Assignee
Alkalidx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkalidx, Inc. filed Critical Alkalidx, Inc.
Publication of WO2019226599A1 publication Critical patent/WO2019226599A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4005—Detecting, measuring or recording for evaluating the nervous system for evaluating the sensory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4821—Determining level or depth of anaesthesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4005—Detecting, measuring or recording for evaluating the nervous system for evaluating the sensory system
    • A61B5/4017—Evaluating sense of taste
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4343—Pregnancy and labour monitoring, e.g. for labour onset detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
    • A61B5/483—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold by thermal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Surgery (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des procédés de diagnostic et de traitement de sujets humains (par exemple, des femmes enceintes, des sujets présentant un trouble de stress, des sujets à subir une procédure dermatologique, une injection ou un cathétérisme) qui sont insensibles à un anesthésique, par exemple la lidocaïne en administrant d'abord l'anesthésique, par exemple la lidocaïne, et en déterminant son efficacité. Certains patients sont ensuite administrés en outre un second anesthésique s'ils sont découverts comme étant insensibles à l'anesthésique, par exemple, la lidocaïne. D'autres modes de réalisation comprennent le traitement de ces patients avec un agent qui augmente les taux sériques de potassium et/ou d'autres agents thérapeutiques.
PCT/US2019/033226 2018-05-22 2019-05-21 Diagnostics et traitements de sujets insensibles à un anesthésique WO2019226599A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862674839P 2018-05-22 2018-05-22
US62/674,839 2018-05-22

Publications (1)

Publication Number Publication Date
WO2019226599A1 true WO2019226599A1 (fr) 2019-11-28

Family

ID=68616454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/033226 WO2019226599A1 (fr) 2018-05-22 2019-05-21 Diagnostics et traitements de sujets insensibles à un anesthésique

Country Status (1)

Country Link
WO (1) WO2019226599A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973890B2 (en) 2016-09-13 2021-04-13 Allergan, Inc. Non-protein clostridial toxin compositions
WO2023230303A1 (fr) * 2022-05-27 2023-11-30 Lerer Leonard Traitement de déclin cognitif lié à l'anesthésie et à la sédation

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032109A2 (fr) * 1995-04-13 1996-10-17 Chiroscience Limited Levobupivacaine et son utilisation comme anesthesique chez la femme enceinte
WO2001019403A1 (fr) * 1999-09-14 2001-03-22 Lim Jung Ok Melange, encapsule dans un liposome, d'anesthesiques topiques et procede de fabrication
WO2004058329A2 (fr) * 2002-12-20 2004-07-15 The Board Of Trustees Of The Leland Stanford Junior University Anesthesique local a base d'une combinaison d'ester
US20050074466A1 (en) * 2001-07-27 2005-04-07 Suskind Dana L. Botulinum toxin in the treatment or prevention of acne
US20050165097A1 (en) * 2000-05-12 2005-07-28 Eckard Weber Local anesthetic methods and kits
US20100234828A1 (en) * 2009-03-11 2010-09-16 Andrew Boyle Methods and Compositions for Facilitating Arterial Access
US20140066843A1 (en) * 2011-03-07 2014-03-06 3M Innovative Properties Company Microneedle devices and methods
US8828452B2 (en) * 2007-05-22 2014-09-09 Glenn Abrahmsohn Method for pain control
US20150224093A1 (en) * 2013-10-11 2015-08-13 Eugene Lipov Kits and Methods for Treating Post Traumatic Stress Disorder (PTSD) and Hot Flashes
US20180049985A1 (en) * 2012-05-10 2018-02-22 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032109A2 (fr) * 1995-04-13 1996-10-17 Chiroscience Limited Levobupivacaine et son utilisation comme anesthesique chez la femme enceinte
WO2001019403A1 (fr) * 1999-09-14 2001-03-22 Lim Jung Ok Melange, encapsule dans un liposome, d'anesthesiques topiques et procede de fabrication
US20050165097A1 (en) * 2000-05-12 2005-07-28 Eckard Weber Local anesthetic methods and kits
US20050074466A1 (en) * 2001-07-27 2005-04-07 Suskind Dana L. Botulinum toxin in the treatment or prevention of acne
WO2004058329A2 (fr) * 2002-12-20 2004-07-15 The Board Of Trustees Of The Leland Stanford Junior University Anesthesique local a base d'une combinaison d'ester
US8828452B2 (en) * 2007-05-22 2014-09-09 Glenn Abrahmsohn Method for pain control
US20100234828A1 (en) * 2009-03-11 2010-09-16 Andrew Boyle Methods and Compositions for Facilitating Arterial Access
US20140066843A1 (en) * 2011-03-07 2014-03-06 3M Innovative Properties Company Microneedle devices and methods
US20180049985A1 (en) * 2012-05-10 2018-02-22 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof
US20150224093A1 (en) * 2013-10-11 2015-08-13 Eugene Lipov Kits and Methods for Treating Post Traumatic Stress Disorder (PTSD) and Hot Flashes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973890B2 (en) 2016-09-13 2021-04-13 Allergan, Inc. Non-protein clostridial toxin compositions
WO2023230303A1 (fr) * 2022-05-27 2023-11-30 Lerer Leonard Traitement de déclin cognitif lié à l'anesthésie et à la sédation

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