WO2019215911A1 - Dispositif de commutation de canal d'écoulement - Google Patents

Dispositif de commutation de canal d'écoulement Download PDF

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Publication number
WO2019215911A1
WO2019215911A1 PCT/JP2018/018321 JP2018018321W WO2019215911A1 WO 2019215911 A1 WO2019215911 A1 WO 2019215911A1 JP 2018018321 W JP2018018321 W JP 2018018321W WO 2019215911 A1 WO2019215911 A1 WO 2019215911A1
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WO
WIPO (PCT)
Prior art keywords
flow path
body housing
switching device
main body
path switching
Prior art date
Application number
PCT/JP2018/018321
Other languages
English (en)
Japanese (ja)
Inventor
真悟 藤岡
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Priority to JP2020517735A priority Critical patent/JP6881680B2/ja
Priority to PCT/JP2018/018321 priority patent/WO2019215911A1/fr
Publication of WO2019215911A1 publication Critical patent/WO2019215911A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns

Definitions

  • the present invention relates to a flow path switching device for switching a liquid flow path.
  • each component in the liquid sample is separated and separated in the column by supplying the liquid sample to the liquid chromatograph column.
  • Each component is introduced into a mass spectrometer (for example, see Patent Document 1 below).
  • Some devices of this type are provided with a flow channel switching device for switching the flow channel to the flow channel of the liquid sample introduced from the liquid chromatograph into the mass spectrometer.
  • the flow path switching device is used, for example, to switch and guide a liquid sample supplied from a liquid chromatograph to an ionization probe or drain in a mass spectrometer.
  • a diverter valve can be used as the flow path switching device as described above.
  • a configuration of the diverter valve a configuration having a stator and a rotor in a hollow main body housing can be considered.
  • the stator is a plate-like member fixed in the main body housing.
  • the rotor is a rotatable plate-like member that contacts the stator, and the flow path can be switched by rotating the rotor relative to the stator.
  • An opening is formed in the body housing, and the opening is closed by the lid member by attaching the lid member to the body housing in a state where the stator and the rotor are accommodated in the body housing.
  • stator and the rotor are in sliding contact with each other, they are consumed with use. For this reason, it is necessary to periodically remove the lid member from the main body housing and replace the stator and the rotor.
  • the lid member is fixed to the main body housing by tightening a plurality of screws, for example. Therefore, when exchanging the stator and the rotor, after loosening a plurality of screws and removing the lid member, the stator and the rotor in the main body housing are exchanged through the opening. After the replacement, the opening is covered with the lid member, and the plurality of screws are tightened again to attach the lid member to the main body housing.
  • the present invention has been made in view of the above circumstances, and an object thereof is to provide a flow path switching device capable of attaching a lid member to a main body housing by uniformly tightening a plurality of screws.
  • a flow path switching device is a flow path switching device for switching a liquid flow path, and includes a main body housing, a flow path switching mechanism, a lid member, a plurality of screws, and a stopper mechanism.
  • the main body housing is hollow and has an opening.
  • the flow path switching mechanism is housed in the main body housing and switches the flow path.
  • the lid member is detachable from the main body housing and closes the opening of the main body housing.
  • the plurality of screws fix the lid member to the main body housing.
  • the stopper mechanism limits a rotation range of a tool for rotating the plurality of screws.
  • the flow path switching mechanism has a plate-like stator fixed in the main body housing and a rotatable plate-like rotor that contacts the stator, and rotates the rotor with respect to the stator. Switch the flow path.
  • the stopper mechanism limits the rotation range of the tool when rotating each screw within a predetermined angle range.
  • the lid member can be attached to the main body housing by uniformly tightening the plurality of screws.
  • Each of the plurality of screws may be formed with a hexagon hole for inserting an end of a hexagon wrench as the tool.
  • the predetermined angle range may be 60 ° or more.
  • each screw can be rotated using a hexagon wrench as a tool, and the lid member can be attached to the main body housing.
  • the predetermined angle range to 60 ° or more, rotate each screw by 60 ° or more, and then rotate again by changing the direction (angle) for inserting the end of the hexagon wrench into the hexagon hole of each screw. Can be smoothly performed.
  • the difference in the predetermined angle range corresponding to each screw is preferably within ⁇ 5 ° of each other.
  • the channel switching device may further include a display unit that displays a channel switching state by the channel switching device.
  • the stopper mechanism may be configured by an attachment surface to which the display unit is attached.
  • the rotation range of the tool when rotating the screw is within a predetermined angle range using the mounting surface of the display unit for displaying the switching state of the flow path by the flow path switching device.
  • the flow path switching device may further include an exterior member that houses the main body housing therein.
  • at least a part of the stopper mechanism may be constituted by the inner surface of the exterior member.
  • the rotation range of the tool when rotating the screw can be limited to a predetermined angle range by using the inner surface of the exterior member that accommodates the main body housing. Therefore, it is not necessary to provide a separate member as a stopper mechanism, and the manufacturing cost can be reduced.
  • the lid member can be attached to the main body housing by uniformly tightening the plurality of screws.
  • FIG. 5 is a cross-sectional view of the flow path switching device along the line AA in FIG. 4. It is a schematic plan view for demonstrating the aspect at the time of tightening a 1st screw
  • FIG. 1 is a schematic diagram showing a configuration of a liquid chromatograph mass spectrometer 1 according to an embodiment of the present invention.
  • a liquid chromatograph mass spectrometer 1 includes a liquid chromatograph (LC) 2 that separates components in a sample, and a mass spectrometer (MS) 3 that performs mass analysis on the sample components separated by the liquid chromatograph 2. It is a device that combines.
  • LC liquid chromatograph
  • MS mass spectrometer
  • the mobile phase stored in the storage tank is sent toward the column at a constant flow rate. Then, a sample is injected into the mobile phase, and the sample components contained in the mobile phase are temporally separated in the column. The separated sample component is sent to the mass spectrometer 3 via the pipe 4.
  • the mass spectrometer 3 includes a housing 5, a flow path switching device 6, a mass analyzer 7, a drain tray 8, a drain sensor 9, pipes 10 and 11, and the like.
  • the flow path switching device 6 is mounted in the housing 5.
  • the sample component from the liquid chromatograph 2 flows into the flow path switching device 6 through the pipe 4. Further, the sample component that has flowed from the liquid chromatograph 2 into the flow path switching device 6 flows into the mass analyzer 7 through the pipe 10.
  • the flow path switching device 6 is an apparatus that is interposed in the flow path of the sample from the liquid chromatograph 2 to the mass analyzer 7 and switches the flow path of the sample (liquid). The detailed configuration of the flow path switching device 6 will be described later.
  • the mass analyzer 7 is accommodated in the housing 5.
  • the introduced sample component is ionized, and the ions are separated according to the mass-to-charge ratio (m / z). Then, in the detector (not shown), the separated ions are detected, and mass spectrometry is performed.
  • the drain tray 8 is disposed in the housing 5 at a position away from the flow path switching device 6.
  • the pipe 11 is fixed to the housing 5 so as to extend from the flow path switching device 6 to the drainage tray 8.
  • the drainage sensor 9 is provided in the drainage tray 8.
  • the drainage sensor 9 detects the sample drained to the drainage tray 8.
  • the drainage sensor 9 and the drainage tray 8 constitute a drainage unit 12.
  • the sample components separated by the liquid chromatograph 2 flow into the mass analyzer 7 via the pipe 4, the flow path switching device 6 and the pipe 10. .
  • the leaked sample is discharged to the drain tray 8 via the pipe 11. In this case, the sample discharged to the drain tray 8 is detected by the drain sensor 9.
  • FIG. 2 is a diagram showing a flow path in the liquid chromatograph mass spectrometer 1, and shows a state in which sample components flow from the liquid chromatograph 2 to the mass analyzer 7.
  • the flow path switching device 6 has six ports a to f. Each port a to f corresponds to an opening 241A of the lid member 24 described later.
  • the port a of the flow path switching device 6 communicates with the liquid chromatograph 2. That is, the pipe 4 (see FIG. 1) is connected to the port a of the flow path switching device 6.
  • the port b of the flow path switching device 6 communicates with the mass analyzer 7. That is, the pipe 10 (see FIG. 1) is connected to the port b of the flow path switching device 6.
  • the port c of the flow path switching device 6 communicates with the standard sample introduction unit 15.
  • the standard sample introduction unit 15 introduces a standard sample (STD) into the flow path switching device 6.
  • Port d and port f of the flow path switching device 6 communicate with the drain flow path.
  • the port a and the port b of the flow path switching device 6 communicate with each other, and the port c and the port d communicate with each other. Therefore, as described above, the sample components separated by the liquid chromatograph 2 flow into the mass analyzer 7 through the flow path switching device 6. Further, the standard sample delivered from the standard sample introduction unit 15 is discharged to the drain channel via the channel switching device 6.
  • FIG. 3 is a diagram showing a state where the flow path of the flow path switching device 6 is switched from the state of FIG. In this state, the port a and the port f of the flow path switching device 6 communicate with each other, and the port b and the port c communicate with each other. Therefore, the standard sample sent out from the standard sample introduction unit 15 flows into the mass analysis unit 7 via the flow path switching device 6. Further, in the liquid chromatograph 2, a mobile phase not containing a sample is flowed, and this mobile phase is discharged to the drain flow path via the flow path switching device 6.
  • the flow path switching device 6 appropriately switches the flow path, and the analysis operation is performed.
  • the flow path switching device 6 houses a mechanism for switching the flow path (flow path switching mechanism) and the like, and therefore requires periodic maintenance work.
  • the flow path switching device 6 is configured as follows so that the operation for the flow path switching device 6 can be smoothly performed.
  • FIG. 4 is a perspective view showing the configuration of the channel switching device 6.
  • FIG. 5 is a cross-sectional view of the flow path switching device 6 along the line AA in FIG. FIG. 4 shows a state in which a part of the housing 5 is omitted.
  • the flow path switching device 6 in this embodiment includes a main body housing 21, a rotation mechanism 22, a flow path switching mechanism 23, a lid member 24, and the like.
  • the main body housing 21 is fixed to the housing 5.
  • the main body housing 21 is a hollow member extending in the vertical direction.
  • the main body housing 21 is formed with a recess 21A and a through hole 21B.
  • the recess 21 ⁇ / b> A is recessed downward from the upper surface of the main body housing 21, and the upper end thereof constitutes an opening of the main body housing 21.
  • the through hole 21B penetrates the lower end portion of the main body housing 21 in the vertical direction and communicates with the concave portion 21A.
  • the rotation mechanism 22 is inserted into the main body housing 21 from below the main body housing 21.
  • the rotating mechanism 22 includes a motor shaft 26, a rotating body 27, and a coupling 28.
  • the motor shaft 26 is disposed below the main body housing 21 in the housing 5.
  • the motor shaft 26 is formed in a bar shape extending in the vertical direction.
  • the motor shaft 26 can rotate around an axis extending in the vertical direction.
  • the motor shaft 26 rotates when a driving force from a motor (not shown) is applied.
  • the rotating body 27 is disposed above the motor shaft 26, and a part thereof is disposed in the main body housing 21.
  • the rotating body 27 includes a shaft portion 29 and a holding portion 30.
  • the shaft portion 29 is formed in a rod shape extending in the vertical direction.
  • the diameter of the shaft portion 29 is slightly smaller than the diameter of the through hole 21 ⁇ / b> B of the main body housing 21.
  • the holding portion 30 is provided at the upper end portion of the shaft portion 29.
  • the holding part 30 is formed in a substantially cylindrical shape.
  • the diameter of the holding portion 30 is larger than the diameter of the shaft portion 29 and slightly smaller than the diameter of the concave portion 21 ⁇ / b> A of the main body housing 21.
  • the rotating body 27 is rotatably held in the main body housing 21 with the shaft portion 29 inserted through the through hole 21B.
  • the upper portion of the shaft portion 29 and the holding portion 30 are accommodated in the main body housing 21 (inside the recess 21 ⁇ / b> A), and the lower portion of the shaft portion 29 is disposed outside (lower) the main body housing 21.
  • the coupling 28 connects the shaft portion 29 of the rotating body 27 and the motor shaft 26.
  • the coupling 28 has an upper end connected to the lower end of the shaft 29, and a lower end connected to the upper end of the motor shaft 26. Thereby, when the motor shaft 26 rotates, the rotating body 27 rotates together with the coupling 28.
  • the flow path switching mechanism 23 is a mechanism for switching the flow path in the flow path switching device 6.
  • the flow path switching mechanism 23 is accommodated in the main body housing 21 (in the recess 21 ⁇ / b> A) and is disposed above the holding portion 30 of the rotating body 27.
  • the flow path switching mechanism 23 includes a rotor 31 and a stator 32.
  • the rotor 31 is disposed above the holding unit 30 of the rotating body 27.
  • the rotor 31 is formed in a disk shape.
  • the rotor 31 has a plurality of grooves (not shown) extending in the circumferential direction.
  • the rotor 31 is detachably attached to the upper surface of the holding unit 30 such that the central axis thereof coincides with the central axis of the holding unit 30.
  • the stator 32 is disposed above the rotor 31.
  • the stator 32 is formed in a disk shape.
  • the stator 32 is formed with a plurality of openings (not shown) arranged at intervals in the circumferential direction.
  • the stator 32 is in contact with the upper surface of the rotor 31 in a state where the stator 32 is fixed at a fixed position in the main body housing 21 so that the center axis thereof coincides with the center axis of the rotor 31.
  • the lid member 24 is formed in a disc shape having an outer diameter larger than the inner diameter of the opening of the main body housing 21 (the upper end of the recess 21A).
  • the lid member 24 is detachable from the main body housing 21.
  • the lid member 24 closes the opening of the main body housing 21 by being attached to the main body housing 21 along a horizontal plane.
  • the central portion 241 of the lid member 24 forms a protruding portion that protrudes upward.
  • a plurality of openings 241A are formed in the central portion 241 of the lid member 24, and a groove 242A and a drainage port 242B are formed in the outer edge portion 242 of the lid member 24.
  • Each opening 241A passes through the central portion 241 of the lid member 24.
  • Each opening 241 ⁇ / b> A communicates with a plurality of openings formed in the stator 32.
  • Each opening 241A corresponds to each of the ports a to f (see FIGS. 2 and 3).
  • FIG. 5 shows a state in which some of the openings 241A are sealed by the sealing member 35.
  • the unused opening 241 ⁇ / b> A among the plurality of openings 241 ⁇ / b> A of the lid member 24 may be sealed by the sealing member 35.
  • the groove 242A is an annular recess formed in the upper surface of the outer edge 242 of the lid member 24 and extending in the circumferential direction.
  • the groove 242A is recessed in a V-shaped cross section from the upper surface of the outer edge portion 242 downward.
  • the drainage port 242B penetrates the outer edge portion 242 in the vertical direction so as to communicate with the groove 242A.
  • a pipe joint 40 is provided in the housing 5.
  • the pipe joint 40 includes a vertical portion 41 and a horizontal portion 42 each formed in a tubular shape.
  • the vertical portion 41 extends in the vertical direction and is close to the outer peripheral surface of the main body housing 21.
  • the upper end portion of the vertical portion 41 communicates with the drainage port 242B.
  • the horizontal portion 42 extends in the horizontal direction (in the direction away from the main body housing 21) continuously from the lower end portion of the vertical portion 41.
  • the tip of the horizontal portion 42 is connected to one end of the pipe 11 (see FIG. 1).
  • three screws 50 are provided at equal intervals in the circumferential direction with respect to the center of the lid member 24. That is, with respect to the center of the lid member 24, the angular interval between the mounting positions of the screws 50 is constant (about 120 °). Since the lid member 24 can be fixed horizontally with respect to the main body housing 21 by tightening the plurality of screws 50 equally spaced in this way, the contact surface between the stator 32 and the rotor 31 The surface pressure becomes uniform.
  • a hexagonal hole 51 is formed in the head of each screw 50.
  • a hexagon wrench 52 see FIGS. 6A to 6C as a tool is inserted into the hexagon hole 51 of each screw 50.
  • the hexagon wrench 52 is a bar-shaped member having a hexagonal cross section, and has a shape bent or curved in an L shape.
  • FIG. 6A is a schematic plan view for explaining an aspect when the first screw 50A is tightened.
  • the first stopper member 53A and the second stopper member 53B are placed on the track of the hexagon wrench 52 when the end of the hexagon wrench 52 is inserted into the hexagon hole 51 of the first screw 50A and the hexagon wrench 52 is rotated. Is provided.
  • Each of the first stopper member 53A and the second stopper member 53B is a rod-like member attached to the housing 5, and extends in the vertical direction.
  • each stopper member 53A, 53B functions as a stopper mechanism 53 for limiting the rotation range ⁇ 1 of the hexagon wrench 52.
  • FIG. 6B is a schematic plan view for explaining an aspect when the second screw 50B is tightened.
  • the end of the hexagon wrench 52 is inserted into the hexagon hole 51 of the second screw 50B and the hexagon wrench 52 is rotated, the mounting surface 54A of the display unit 54 and the exterior member 55 are placed on the track of the hexagon wrench 52.
  • the inner surface 55A is provided.
  • the display part 54 is for displaying the switching state of the flow path by the flow path switching device 6, and is constituted by, for example, an LED display.
  • the display unit 54 electrically displays whether the flow path switched by the flow path switching device 6 is in the state of FIG. 2 or FIG.
  • the operator can easily confirm the state of the flow path (the state shown in FIG. 2 or FIG. 3) by looking at the display on the display unit 54.
  • the attachment surface 54 ⁇ / b> A to which the display unit 54 is attached is configured by a part of a sheet metal that forms the housing 5.
  • the attachment surface 54 ⁇ / b> A extends in the vertical direction in the vicinity of the main body housing 21.
  • the exterior member 55 is a decorative member that covers the outside of the housing 5.
  • the exterior member 55 is formed in a hollow shape, and the main body housing 21 and the like are accommodated therein. A part of the inner surface 55 ⁇ / b> A of the exterior member 55 extends in the vertical direction in the vicinity of the main body housing 21.
  • the hexagon wrench 52 When the hexagon wrench 52 is rotated in the state of FIG. 6B, the hexagon wrench 52 contacts the mounting surface 54A of the display unit 54 and the inner surface 55A of the exterior member 55, so that the rotation range ⁇ 2 of the hexagon wrench 52 is within a predetermined angular range. Limited to Thus, the attachment surface 54A to which the display unit 54 is attached and the inner surface 55A of the exterior member 55 function as a stopper mechanism 53 for restricting the rotation range ⁇ 2 of the hexagon wrench 52, respectively.
  • FIG. 6C is a schematic plan view for explaining an aspect when the third screw 50C is tightened.
  • the end of the hexagon wrench 52 is inserted into the hexagon hole 51 of the third screw 50C and the hexagon wrench 52 is rotated, the surface of the display unit 54 and the inner surface of the exterior member 55 are on the track of the hexagon wrench 52. 55A is provided.
  • the hexagon wrench 52 When the hexagon wrench 52 is rotated in the state shown in FIG. 6C, the hexagon wrench 52 comes into contact with the surface of the display unit 54 and the inner surface 55A of the exterior member 55, so the rotation range ⁇ 3 of the hexagon wrench 52 is limited within a predetermined angle range. Is done.
  • the surface of the display unit 54 and the inner surface 55A of the exterior member 55 function as a stopper mechanism 53 for limiting the rotation range ⁇ 3 of the hexagon wrench 52, respectively.
  • the stopper mechanism 53 determines the rotation range ⁇ 1 to ⁇ 3 of the hexagon wrench 52 when rotating each screw 50 (first screw 50A, second screw 50B, and third screw 50C). Therefore, it is possible to prevent only some of the screws 50 from being excessively tightened. Therefore, the lid member 24 can be attached to the main body housing 21 by uniformly tightening the plurality of screws 50.
  • the rotation range ⁇ 1 to ⁇ 3 of the hexagon wrench 52 when rotating each screw 50 is a predetermined range of 60 ° or more (eg, about 70 °). It is preferable that the angle range is limited. Thereby, each screw 50 can be rotated using the hexagon wrench 52 as a tool, and the cover member 24 can be attached to the main body housing 21.
  • the predetermined angle range is set to 60 ° or more, the direction (angle) in which the end of the hexagon wrench 52 is inserted into the hexagon hole 51 of each screw 50 after rotating each screw 50 by 60 ° or more. The work of changing and rotating again can be performed smoothly.
  • the difference between the predetermined angle ranges (rotation ranges ⁇ 1 to ⁇ 3) corresponding to the screws (first screw 50A, second screw 50B, and third screw 50C) is preferably within ⁇ 5 ° of each other. .
  • the number of screws 50 for attaching the lid member 24 to the main body housing 21 is three has been described.
  • the number of screws 50 is not limited to three, but may be two or four or more. Even in such a case, the rotation range of the tool when each screw 50 is rotated may be limited by the stopper mechanism 53.
  • each screw 50 is not limited to the hexagon wrench 52, and any other tool can be used. Therefore, each screw 50 is not limited to the configuration in which the hexagon hole 51 for inserting the end of the hexagon wrench 52 is formed.
  • the channel switching device 6 is not limited to a device for switching the sample channel, but can be used as a device for switching the channel of any other liquid. Therefore, the flow path switching device 6 is not limited to the configuration provided in the mass spectrometer 3 of the liquid chromatograph mass spectrometer 1, but may be a configuration provided in another analyzer, or other than the analyzer. The structure provided in the apparatus may be sufficient.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Selon la présente invention, une pluralité de vis (50) (une première vis (50A), une deuxième vis (50B) et une troisième vis (50C)) sont utilisées pour fixer un élément de couvercle (24) à un boîtier de corps principal. Un mécanisme de butée (53) limite la plage de rotation θ1 d'un outil (une clé hexagonale (52)) qui sert à faire tourner la pluralité de vis (50). Le mécanisme de butée (53) limite la plage de rotation de l'outil à l'intérieur d'une plage angulaire prescrite pour la rotation de chaque vis (50).
PCT/JP2018/018321 2018-05-11 2018-05-11 Dispositif de commutation de canal d'écoulement WO2019215911A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020517735A JP6881680B2 (ja) 2018-05-11 2018-05-11 流路切替装置
PCT/JP2018/018321 WO2019215911A1 (fr) 2018-05-11 2018-05-11 Dispositif de commutation de canal d'écoulement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2018/018321 WO2019215911A1 (fr) 2018-05-11 2018-05-11 Dispositif de commutation de canal d'écoulement

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WO2019215911A1 true WO2019215911A1 (fr) 2019-11-14

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007121164A (ja) * 2005-10-28 2007-05-17 Shimadzu Corp 流路切換バルブ及びそれを用いた高速液体クロマトグラフ
JP2007516394A (ja) * 2003-11-10 2007-06-21 ウオーターズ・インベストメンツ・リミテツド 導管内の流体の流れを制御するデバイスおよび方法
JP2014507646A (ja) * 2011-01-12 2014-03-27 ディオネクス ゾフトロン ゲーエムベーハー 高速液体クロマトグラフィー用の高圧切り替えバルブ
US20140346748A1 (en) * 2013-05-21 2014-11-27 Wabco Europe Bvba Leveling Valve for Discharging and Supplying Fluid
JP2015152033A (ja) * 2014-02-12 2015-08-24 株式会社日立ハイテクノロジーズ 流路切り替えバルブおよび当該バルブを用いた液体クロマトグフラフ装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007516394A (ja) * 2003-11-10 2007-06-21 ウオーターズ・インベストメンツ・リミテツド 導管内の流体の流れを制御するデバイスおよび方法
JP2007121164A (ja) * 2005-10-28 2007-05-17 Shimadzu Corp 流路切換バルブ及びそれを用いた高速液体クロマトグラフ
JP2014507646A (ja) * 2011-01-12 2014-03-27 ディオネクス ゾフトロン ゲーエムベーハー 高速液体クロマトグラフィー用の高圧切り替えバルブ
US20140346748A1 (en) * 2013-05-21 2014-11-27 Wabco Europe Bvba Leveling Valve for Discharging and Supplying Fluid
JP2015152033A (ja) * 2014-02-12 2015-08-24 株式会社日立ハイテクノロジーズ 流路切り替えバルブおよび当該バルブを用いた液体クロマトグフラフ装置

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JPWO2019215911A1 (ja) 2021-02-12

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