WO2019190267A1 - Micro-aiguille multi-type - Google Patents

Micro-aiguille multi-type Download PDF

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Publication number
WO2019190267A1
WO2019190267A1 PCT/KR2019/003717 KR2019003717W WO2019190267A1 WO 2019190267 A1 WO2019190267 A1 WO 2019190267A1 KR 2019003717 W KR2019003717 W KR 2019003717W WO 2019190267 A1 WO2019190267 A1 WO 2019190267A1
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WO
WIPO (PCT)
Prior art keywords
needle
drug
substrate
substrate portion
patch
Prior art date
Application number
PCT/KR2019/003717
Other languages
English (en)
Korean (ko)
Inventor
조성윤
추현욱
정우진
Original Assignee
랩앤피플주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190034533A external-priority patent/KR102291392B1/ko
Application filed by 랩앤피플주식회사 filed Critical 랩앤피플주식회사
Priority to US17/041,445 priority Critical patent/US20210016070A1/en
Priority to CN201980023213.7A priority patent/CN111918691B/zh
Priority to JP2020552210A priority patent/JP7125998B2/ja
Publication of WO2019190267A1 publication Critical patent/WO2019190267A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to multi-type microneedles, and more particularly, to microneedle patches that adhere to the skin and deliver substances such as drugs subcutaneously.
  • Drug delivery system refers to a series of technologies for delivering a substance having pharmacological activity to cells, tissues, organs and organs using various physicochemical techniques.
  • the oral administration method of ingesting the drug by mouth is most commonly used, and there are transdermal penetration methods such as delivering the drug to a part of the human body.
  • transdermal penetration methods such as delivering the drug to a part of the human body.
  • a method of delivering a liquid drug by punching a hole in a patient's skin with a metal injection needle, that is, a drug delivery method using a syringe has been widely used for a long time.
  • the drug delivery method using a syringe causes pain in the patient during the injection of the drug, and also may cause an infection in the patient due to the re-use of the needle due to the hassle of repeated vaccination and the neglect of managing the syringe. have.
  • the above method has a disadvantage in that the patient cannot administer the drug by using a syringe because an inoculator with knowledge of using a syringe is required.
  • the microneedle is a system that delivers a drug by physically drilling a small hole in the stratum corneum.
  • the Frausnicks Group of Georgia Institute of Technology, Georgia made a microneedle array using silicon process technology and suggested the possibility of drug delivery.
  • Many researches are being actively conducted at the beginning, and are made in various sizes and shapes based on various materials such as metal, polymer, glass and ceramic as well as silicon.
  • microneedles are used for the delivery of active substances such as drugs and vaccines in vivo, detection of bioanalytes in the body, and biopsy, and injection of other skin cosmetics or drugs into skin tissue or from the inside of the skin. It is also used for the purpose of extracting the same body fluids. Therefore, microneedles can be said to be one of the drug delivery methods that are very rapidly used in various fields since local needle injection is possible locally and minimizes pain when inserted into the skin.
  • the microneedle of the polymer material of the existing microneedles does not penetrate into the stratum corneum of the skin as a body has a physical property limitation that does not diffuse the drug smoothly into the body.
  • the inventors of the present invention have proposed a number of technical descriptions of microneedles using a biodegradable metal material, which increases the rigidity of the metal material to increase penetration into the stratum corneum, and additionally benefits the human body.
  • the microneedle 10 is an initial form of the biodegradable metal solid microneedle, and has a high penetration force into the stratum corneum, thereby enhancing the drug delivery effect.
  • the substrate portion 1 of the microneedle 10 is generally manufactured using a mold, and the substrate portion 1 manufactured by a mold method is pressed by a press in a post process. Then, the plurality of needles 2 formed on the substrate portion 1 may be pressed by the press and bent and protruded on the substrate portion 1.
  • the microneedle 10 shown in FIG. 1 has a structure in which a plurality of needles 2 are arranged at a predetermined interval on the substrate portion 1 as described above, a plurality of microneedles 10 have a complex structure.
  • a movable mold ie, a movable mold having a pressing piece which is in correspondence with each of the plurality of needles 2, is to be mounted.
  • the substrate portion disposed between the plurality of needles 2 is rather narrowed when the spacing between the needles 2 is narrowed.
  • the part of 1) is disposed closer to the pressing piece, it may be easily deformed or broken.
  • the present applicant has been proposed the present invention to solve the above problems, the related prior art documents, the Republic of Korea Patent Publication No. 10-2014-0105686 'for stimulating the pain area or acupuncture points of the body Microneedle patch '.
  • the present invention is to solve the above problems, the drug to be delivered to the user's body can be quickly penetrated or diffused, and also before the adhered to the skin or even after the amount of drug to be delivered to the body It is an object to provide a multi-type microneedle configured to be easily adjusted as needed.
  • the present invention the substrate portion; Needle holes provided in a plurality in the substrate portion; Needle parts provided in a plurality at predetermined intervals along the circumferential direction of the needle ball at a portion of the substrate part that divides the needle ball; And a patch in contact with the skin of the user while being in contact with one surface of the substrate unit.
  • the patch may be provided with a drug inlet for the drug to be delivered into the body.
  • the drug injection portion may be provided on the patch in the form of an opening connected to communicate with a plurality of needle holes provided in the substrate portion.
  • At least one drug injection unit may be provided in the substrate unit.
  • the substrate unit may be provided with a drug storage unit for storing the drug to be delivered into the body.
  • the drug reservoir may be interposed between the substrate portion and the patch in the form of an absorbent pad.
  • the drug storage unit is made of a non-absorbent material and interposed between the substrate portion and the patch, it may have an annular ring shape.
  • the drug storage unit may have a form protruding outward on the patch while forming a predetermined space in which the drug may be stored.
  • the drug storage unit is provided to protrude to the outside of the patch while forming the space portion, one side of the storage member having an open form so that the drug flow; And a connecting member integrally connected to one side circumferential surface of the storage member and interposed between the substrate portion and the patch.
  • the blocking member for blocking the open one side of the storage member may further include a.
  • the storage member may protrude in a shape having a hemispherical cross section on the patch or protrude in a shape having a cross-section of a 'c' shape.
  • the opening formed at one side of the storage member may include an entirety of the plurality of needle holes provided in the substrate portion or may have an area including some of the plurality of needle holes provided in the substrate portion.
  • the drug storage unit may be provided in the substrate unit in a plurality of numbers.
  • the needle hole may be provided in the substrate portion in the form of a circular or regular polygon.
  • the needle part may be provided at the center of the inner side of the substrate part that divides the needle hole.
  • one end of the needle portion may be connected to a portion of the substrate portion that partitions the needle hole, and the other end may protrude from the other surface of the substrate portion and be inserted into the user's skin.
  • the needle portion or the substrate portion may include a supporting groove for providing a path for the drug flow.
  • the supporting groove may be provided on one surface or the other surface of the substrate portion, and one end in the longitudinal direction may be connected to a portion of the area formed by the substrate portion, and the other end in the longitudinal direction may extend toward the other end of the needle portion.
  • the support groove may further include a slit groove connected to communicate from the other end in the longitudinal direction of the needle portion to the tip.
  • a supporting hole may be formed in a portion of the substrate portion or the needle portion in which the supporting groove is formed along a direction in which the supporting groove is formed.
  • the substrate portion may have a honeycomb structure.
  • the substrate portion or the needle portion may be formed of a bioabsorbable metal.
  • bioabsorbable metal may be a metal including at least one component of magnesium, calcium, zinc and iron.
  • the multi-type microneedle according to an embodiment of the present invention has a configuration in which a plurality of needle portions are provided in a predetermined pattern around one needle hole, so that a plurality of needle portions are inserted into a predetermined area of skin to deliver a drug to be delivered to the body. Can spread or penetrate quickly subcutaneously.
  • the multi-type microneedle since the multi-type microneedle according to an embodiment of the present invention has a structure that can control the amount of drug delivered to the body through the drug inlet or the drug reservoir, the microneedle may be used in response to a user's preference or patient's condition. Can be.
  • the multi-type microneedle according to an embodiment of the present invention has a structure that can adjust the amount of the drug delivered to the body before or after being attached to the skin, it is easy to the physical condition of the user It can be used correspondingly.
  • the multi-type microneedle since the substrate portion may have a honeycomb structure by a needle hole formed in the shape of a regular hexagon, the substrate portion is deformed or damaged by a press in the press pressing process to bend the needle portion Can be minimized.
  • the multi-type microneedle according to an embodiment of the present invention can protrude a plurality of needle parts on the substrate portion without providing the number of the pressing pieces provided in the movable mold of the press equal to the number of the needle portion, the movable mold of the press As a result, manufacturing costs can be reduced, thereby reducing the manufacturing cost of microneedles and simplifying the manufacturing process.
  • FIG. 1 is a perspective view of a conventional microneedle.
  • FIG. 2 is a perspective view of a multi-type microneedle according to an embodiment of the present invention.
  • FIG. 3 is an exploded perspective view of the multi-type microneedle shown in FIG.
  • FIG. 4 is a plan view of the multi-type microneedle shown in FIG.
  • FIG. 5 is a rear view of the multi-type microneedle shown in FIG.
  • FIG. 6 is a perspective view of a multi-type microneedle provided with a drug storage unit according to an embodiment of the present invention.
  • FIG. 7 is an exploded perspective view of the multi-type microneedle shown in FIG. 6.
  • FIG. 7 is an exploded perspective view of the multi-type microneedle shown in FIG. 6.
  • FIG. 8 is a perspective view of a multi-type microneedle provided with a drug reservoir according to another embodiment of the present invention.
  • FIG. 9 is an exploded perspective view of the multi-type microneedle shown in FIG. 8.
  • FIG. 10 is a perspective view of a multi-type microneedle provided with a drug reservoir according to another embodiment of the present invention.
  • FIG. 11 is a cross-sectional view of the drug reservoir shown in FIG. 10.
  • FIG. 11 is a cross-sectional view of the drug reservoir shown in FIG. 10.
  • Figure 12 is a perspective view of the drug reservoir consisting of a storage member having a cross-section of the '' '.
  • Figure 13 (a) is a perspective view showing a state in which the drug storage unit shown in Figure 8 is provided in the substrate portion of another form.
  • FIG. 13B is a cross-sectional view of the multi-type microneedle shown in FIG. 13A.
  • Figure 14 (a) is a perspective view showing a state in which the drug storage unit shown in Figure 10 is provided in the substrate portion of another form.
  • FIG. 14B is a cross-sectional view of the multi-type microneedle shown in FIG. 14A.
  • the multi-type micro needle 100 according to an embodiment of the present invention, the substrate portion 110, the needle hole 120 is provided in a plurality in the substrate portion 110 And a plurality of needle parts 130 and the substrate part provided at a predetermined interval from each other along the circumferential direction of the needle hole 120 at a portion of the substrate part 110 partitioning the needle hole 120. It may include a patch 140 in contact with the skin of the user while being in contact with one surface of the 110.
  • the substrate unit 110 may have a shape of a thin metal plate having a predetermined area and thickness, and one surface thereof may contact the patch 140 and the other surface may contact the user's skin. .
  • the substrate 110 may be manufactured in various shape sizes and shapes corresponding to the skin portion to be attached, and the periphery thereof may be formed to have various curvatures so as to be in airtight contact with the curved skin portion. Can be.
  • the substrate 110 when the substrate 110 is attached to the nose portion of the user may be manufactured in the form of a known nose pack.
  • the substrate 110 may be loaded with a drug to be delivered subcutaneously.
  • a method of supporting the drug on the substrate unit 110 a method of dipping the substrate unit 110 in a container in which the drug is stored and coating or coating the drug by applying the drug to the substrate unit 110 is known. Manner may be used.
  • the drug contained in the substrate 110 may be a drug for the purpose of preventing and treating diseases, but is not limited thereto.
  • EGF Epidermal Growth Factor: epidermal growth factor
  • skin beauty Or hyaluronic acid for genetic material or skin beauty Or hyaluronic acid.
  • the needle hole 120 is a component that can be formed by processing the substrate unit 110 by a known laser cutting device or etching molding, and as described above, the needle hole 120 is formed on each other on the surface of the substrate unit 110. It can be provided in plural at regular intervals.
  • the needle hole 120 may be formed in the substrate part 110 in a circular or regular polygonal shape.
  • the needle part 130 may be provided on an inner side surface of the substrate part 110 that partitions the needle hole 120.
  • the needle part 130 may be provided at the center of the inner side of the substrate part 110 partitioning the needle hole 120.
  • one end in the longitudinal direction of the needle part 130 may be connected to a portion of the substrate part 110 that defines the needle hole 120, and the other end in the longitudinal direction may extend toward the center of the needle hole 120. have.
  • the needle part 130 may be bent and protruded vertically on the other surface of the substrate part 110 by a pressing process using a molding process or a press device. That is, the needle part 130 may be referred to as a component that is inserted under the user's skin when the substrate part 110 contacts the skin of the user and delivers the drug contained in the substrate part 110 and itself.
  • the drug injected into the drug injecting unit 150 to be described later may also be referred to as a component to be delivered to the subcutaneous of the user.
  • a supporting groove 133 may be further provided in the needle part 130 and the substrate part 110.
  • the supporting groove 133 is provided on one surface or the other surface of the substrate unit 110, one end in the longitudinal direction of which is disposed in a portion of the area formed by the substrate unit 110, and the other end in the longitudinal direction of the needle unit 130. ), That is, extends toward the other end in the longitudinal direction of the needle part 130.
  • the supporting groove 133 may be selectively provided on one surface or the other surface of the substrate unit 110. In an embodiment of the present invention, the supporting groove 133 is provided on both one surface and the other surface of the substrate unit 110. Is shown.
  • the supporting groove 133 as described above not only forms a path through which the drug supported on the substrate unit 110 or the needle unit 130 can flow, but also the substrate unit 110 or the needle unit 130. ) Provides a space for the drug to be stored so that the amount of drug delivered to the body can be controlled.
  • the supporting groove 133 may have a form in which the inner diameter gradually decreases toward the thickness direction of the substrate portion 110 or the needle portion 130.
  • the supporting groove 133 configured as described above may be formed by increasing the planar area of the substrate 110 or the needle 130 according to the shape of the drug supported on the substrate 110 or the needle 130.
  • a flow path may be provided so that the drug supported on the substrate portion 110 or the needle portion 130 can be easily delivered subcutaneously.
  • the plate surface of the skin and the needle part 130 is in close contact with each other so that the drug is hard to flow.
  • the supporting groove Drugs stored in 133
  • the drug supported on the substrate unit 110 or the needle unit 130 may flow along the forming direction of the supporting groove 133 to be delivered subcutaneously.
  • the multi-type micro needle 100 from the other end in the longitudinal direction of the supporting groove 133, the tip of the needle portion 130, that is, the other end in the longitudinal direction of the needle 130 It may further include a slit groove 134 is communicatively connected to.
  • the slit groove 134 serves to allow the drug stored in the supporting groove 133 or the supporting hole 135 to be described later to easily flow to the tip of the needle part 130, and thus, the Drugs contained in the substrate 110 or the needle 130 may be more easily delivered to the user's subcutaneous via the supporting groove 133 and the slit groove 134.
  • a supporting hole 135 may be further provided in the supporting groove 133. That is, the supporting hole 135 may be formed in a portion of the substrate portion 110 or the needle portion 130 on which the supporting groove 133 is formed along the direction in which the supporting groove 133 is formed.
  • the supporting hole 135 connects one surface and the other surface of the substrate portion 110 or one surface and the other surface of the needle portion 130 to communicate with each other, and thus, the substrate portion 110 or the needle portion 130. Drugs carried on one side or the other side of the) can communicate with each other so that the drug can quickly spread in the user's skin.
  • the supporting hole 135 provides a space in which the drug can be stored similarly to the supporting groove 133, the amount of the drug supported on the substrate 110 or the needle 130 is controlled.
  • the needle hole 135 may be formed in a form in which the inner diameter gradually decreases from one surface of the needle portion 130 or the substrate portion 110 to the other surface direction or from the other surface to one surface direction.
  • the drug coating layer formed to be supported on the 130 may be provided to accommodate a space.
  • the needle portion 130 has a configuration provided in plurality at regular intervals on the needle hole 120 formed on the substrate portion 110 Therefore, the drug to be supplied into the body can be delivered intensively subcutaneously and rapidly spread.
  • the substrate 110 may have a honeycomb structure.
  • the substrate unit 110 having a honeycomb structure presses the needle hole 120 in the process of pressing the pressing portion of the press to bend the plurality of needle portions 130 arranged around the needle hole 120. Deformation or breakage of the portion 110a (see FIG. 1) of the substrate portion 110 to be partitioned by the pressing piece can be prevented.
  • the portion 110a (see FIG. 1) of the substrate portion 110 disposed at the portion may be deformed or torn by being affected by the pressing piece 110.
  • the substrate unit 110 may be formed in a honeycomb structure by providing the multi-type microneedle 100 and the needle hole 120 in the form of a regular hexagon according to an embodiment of the present invention.
  • the overall strength of the 110 may be increased to prevent deformation or breakage of the substrate 110 in a work process using a press.
  • the plurality of needle parts 130 may be bent and protruded on the substrate part 110 by one pressing piece inserted into one needle hole 120. Therefore, it is not necessary to provide the number of the pressing pieces provided in the movable mold of the press to the number corresponding to the number of the needle portion 130, so that the structure of the movable mold can be simplified as a whole. Since the manufacturing cost of the mold is reduced, the manufacturing cost of the multi-type microneedle 100 may be reduced and the manufacturing process may be simplified.
  • the multi-type micro needle 100 may be formed of a bioabsorbable metal. That is, the substrate unit 110 or the needle unit 130 may be formed of a bioabsorbable metal composed of components beneficial to the human body.
  • the substrate unit 110 may be made of a metal including at least one component of magnesium, calcium, zinc, and iron, which are utilized as bioabsorbable metals. Accordingly, the needle provided on the substrate unit 110 may be used.
  • the part 130 is also made of a bioabsorbable metal.
  • bioabsorbable metals are made of magnesium-based alloys for application as orthopedic implants, and are commercially available both at home and abroad. The focus was on slowing speed as much as possible or improving corrosion resistance.
  • the bioabsorbable metal forming the multi-type microneedle 100 accelerates the decomposition rate in the body to supply minerals with subcutaneous drug release. Possible mechanisms can be applied.
  • magnesium, calcium, and zinc which are utilized as bioabsorbable metals, have a mechanism of reacting with water to release hydrogen gas and decomposing as shown in the following [Formula 1] to [Formula 3].
  • the substrate 110 and the needle 130 formed of the bioabsorbable metal as described above release ions and decomposition products under the skin, and the hydrogen gas generated by the by-products provides a swelling effect within the skin to improve wrinkles. Can be derived.
  • the by-products ZnO and MgCl which are produced by inserting magnesium and zinc, which are components of the bioabsorbable metal, into the living body, remain on the skin surface subcutaneously, and the drugs supported by the substrate 110 and the needle 130 are subcutaneously. It may also play the role of a drug delivery enhancer to enhance absorption. Therefore, the substrate unit 110 and the needle unit 130 formed of a bioabsorbable metal can effectively deliver the drug supported thereon to the user.
  • the shape of the needle hole 120 and the needle portion 130 formed in the substrate portion 110 is patterned on the substrate portion 110 by a known lithography or etching technique. Can be formed.
  • the edge of the needle portion 130 may be formed by the lithography or etching technique. It may have a sharp shape that is corroded and thinner than the thickness of the raw material itself so that it can be easily inserted subcutaneously.
  • the multi-type micro needle 100 since the multi-type micro needle 100 according to an embodiment of the present invention includes a needle hole 120 having a relatively large diameter or a larger area than a needle hole formed in a conventional micro needle, the user may Through the ball 120, light therapy (light-therapy; phototherapy) can also be received in parallel.
  • light therapy light-therapy; phototherapy
  • the user's skin may be exposed to the outside through the plurality of needle holes 120, and thus the exposed skin may be exposed to skin diseases such as skin pain, acne, and atopy.
  • Phototherapy can also be easily performed by irradiating beneficial light.
  • the user since the user may be treated by the drug injected into the skin through the needle part 130 and the light irradiated through the needle hole 120, the synergy effect of the drug treatment and the phototherapy can be expected. have.
  • the light exposed to the human body is irradiated to the skin exposed through the needle hole 120, but it has been described as being able to receive a light therapy procedure, but is not limited thereto. That is, the skin treatment material or skin treatment material may be applied to the skin exposed through the needle hole 120 to perform a skin treatment procedure.
  • the patch 140 is a component for bringing the other surface of the substrate unit 110 into close contact with the user's skin, and may be attached to one surface of the substrate unit 110 as described above.
  • the patch 140 may be attached to one surface of the substrate unit 110 while having a larger area than that formed by the substrate unit 110, and may be adhered to a surface facing one surface of the substrate unit 110. It is made of a material that is coated with a substance or has good adhesion to skin.
  • a portion of the patch 140 that is not in contact with the substrate 110 may be referred to as a portion that is attached to the skin of the user. Accordingly, the substrate 110 may be prevented from flowing in the skin of the user. .
  • the patch 140, the drug input unit 150 that provides a path through which the drug can be injected into one surface side of the substrate unit 110 while the other surface of the substrate unit 110 is in contact with the user's skin. May be provided.
  • the drug injector 150 is formed on the patch 140 in the form of an opening connected to communicate with a plurality of needle holes 120 provided in the substrate unit 110. It may be provided in, at least one or more may be provided on the patch 140. In an embodiment of the present invention, two openings are shown in the drawing as being formed in the patch 140 at a predetermined interval from each other.
  • the user may additionally apply the drug on the substrate 110 through the drug inlet 150, the drug applied to the substrate 110 is the needle hole 120 and the needle It may be delivered to the subcutaneous of the user via the unit 130.
  • a method of injecting the drug into the drug injector 150 may be made through a drug supply device having a syringe, and may also be made through an ampule container in which a drug is stored. In addition, a method of adding a sheet impregnated with the drug may be applied.
  • the user may additionally supplement the substrate unit 110 with a drug stored in an ampoule container or a syringe, a drug impregnated in a sheet, and the like, in addition to the drug primarily supported on the substrate unit 110.
  • Multi-type microneedle 100 of the present invention has the advantage that can be used for a long time.
  • the substrate unit 110 may further include a drug storage unit 160 storing a drug to be delivered to the user's body.
  • the drug storage unit 160 may be interposed between one surface of the substrate unit 110 and the patch 140 in the form of an absorbent pad.
  • the absorbent pad may be made of a material such as a sponge, cotton, cotton, polyurethane, etc., which can hold a liquid material for a long time.
  • a material such as a sponge, cotton, cotton, polyurethane, etc.
  • two absorbent pads having a circular shape are provided on one side of the substrate unit 110 and the patch 140 at a predetermined interval from each other.
  • the present invention is not limited thereto and may include at least one on the substrate unit 110.
  • the drug storage unit 160 as described above is a component that allows the user to additionally supplement the drug through the other surface of the substrate unit 110 before attaching the substrate unit 110 to the user's skin.
  • the user may increase or decrease the amount of the drug to suit his or her preference before attaching the substrate 110 to the skin, and when the multi-type microneedle 100 is used for a patient for medical purposes, There may be a doctor or a nurse to adjust the supply of the drug through the drug storage unit 160 according to the condition of the patient.
  • the drug input unit 150 is not formed in the patch 140. This is because the drug absorbed in the drug storage unit 160 may be easily evaporated by wind or air flowing through the drug inlet unit 150.
  • the drug storage unit 160 having an absorbent pad shape may have a size or an area that may include the entirety of the plurality of needle holes 120 provided in the substrate unit 110, or a plurality of needle holes ( It may have a size or area that may include some of the 120).
  • FIGS. 6 and 7 have a size in which the drug storage unit 160 having an absorbent pad shape may include some needle holes 120 among the plurality of needle holes 120 formed in the substrate unit 110. Or it is shown to be provided on the substrate portion 110 with an area.
  • the drug storage unit 170 is made of a non-absorbent material is interposed between one surface of the substrate portion 110 and the patch, annular It may have a ring shape.
  • the non-absorbent material may be made of a thermoplastic material such as polyethylene.
  • a thermoplastic material such as polyethylene.
  • two non-absorbent materials having an annular annular shape are provided between one surface of the substrate unit 110 and the patch 140 at a predetermined interval from each other. It is shown on the figure.
  • the drug storage unit 170 made of the non-absorbent material as described above, rather than the point of absorbing and storing the drug, partitions the space where the drug supplemented by the user can be stored to concentrate the drug in the skin area of the user.
  • the drug injected from the syringe or the ampoule container may be prevented from leaking out of the area formed by the substrate unit 110 to penetrate the patch 140.
  • the drug storage unit 170 made of the non-absorbent material is provided on the substrate unit 110 in the form of a ring, the user may use the syringe or the ampoule container to form the inside of the drug storage unit 170.
  • the supplied drug may be stored in an internal space partitioned by the drug storage unit 170.
  • the drug storage unit 170 made of a non-absorbent material is provided in the substrate unit 110, it is preferable that the drug input unit 150 is not formed in the patch 140. This is because the drug absorbed in the drug storage unit 170 may be easily evaporated by wind or air flowing through the drug inlet unit 150.
  • the ring-shaped drug storage unit 170 is made of a non-absorbent material, has a size or area that can include the entire number of the needle hole 120 provided in the substrate portion 110, or It may have a size or area that may include a portion of the dog needle hole (120).
  • the drug storage unit 170 having a ring shape made of a non-absorbent material may have a portion of the needle holes 120 of the plurality of needle holes 120 formed in the substrate unit 110. It is shown to be provided on the substrate portion 110 with a size or area that can be included.
  • the ring-shaped drug storage unit 170 made of a non-absorbent material has a size or area that may include the entire number of the needle holes 120 provided in the substrate unit 110.
  • the state provided in the substrate unit 110 is shown. That is, the drug storage unit 170 may be provided in the substrate 110 having a substantially regular hexagonal shape, and a plurality of needles provided in the substrate unit 110 in a space partitioned by the drug storage unit 170. All of the balls 120 may be placed.
  • the drug storage unit 180 according to another embodiment of the present invention protrudes outward on the patch 140 while forming a predetermined space in which drugs can be stored. It may have a form. That is, the drug storage unit 180 according to another embodiment of the present invention, may be provided in the saik substrate unit 110 while having a form that the user can press the hand.
  • the drug storage unit 180 is provided to protrude to the outside of the patch 140 while forming the space portion, one side of the storage member 181 having an open shape to allow the drug flow; And a storage member 183 integrally connected to one side circumferential surface of the storage member 181 and interposed between the substrate unit 110 and the patch 140.
  • the storage member 181 may be referred to as a component that provides a space in which the drug is stored and is pressed by the user's hand. As illustrated in FIGS. 10 and 11, the storage member 181 may be provided on the substrate 110 in a shape having a hemispherical cross section to protrude out of the patch 140.
  • the storage member 181 may have various forms without being limited to the hemispherical shape described above, as long as it forms a space in which the drug can be stored and can be easily pressed by the user's hand. Of course. For example, as shown in Figure 12, it may be provided on the substrate portion 110 in the form having a '' 'cross-section.
  • a through hole is formed in a portion of the patch 140 corresponding to the storage member 181 so that the storage member 181 protrudes out of the patch 140 to be pressed by a user's hand. Can be.
  • the storage member 183 may be referred to as a component bonded to one surface of the substrate unit 110, and may be interposed between the substrate unit 110 and the patch 140 as described above.
  • the drug storage unit 130 composed of the storage member 181 and the storage member 183 may be made of a transparent thermoplastic resin, a film material.
  • the drug storage unit 180 as described above allows the user to supplement the drug through the other surface of the substrate unit 110 before the user attaches the substrate unit 110 to the skin. That is, the user may additionally supply the drug to the space portion formed by the storage member 180 through the other surface of the substrate unit 110 using the above-described syringe or ampoule container.
  • the user may increase or decrease the amount of the drug to suit his or her preference before attaching the substrate 110 to the skin, and when the multi-type microneedle 100 is used for a patient for medical purposes, There may be a doctor or a nurse to adjust the supply of the drug through the drug storage unit 180 according to the condition of the patient.
  • one side open to the storage member 181 may be blocked by the blocking member 182 so that the user can selectively use the drug stored in the storage member 181. Accordingly, when the user presses the storage member 181 by hand, the blocking member 182 may be torn due to the pressure, and the drug stored in the storage member 181 may flow out onto the substrate 110.
  • the drug storage unit 180 of another embodiment of the present invention may be used in a manner in which the user supplements the storage member 181 using a syringe or ampoule container, or a package in which the drug is already stored.
  • the substrate unit 110 may be provided to be used.
  • the opening formed at one side of the drug storage unit 180 may have a size or an area that may include the entire plurality of needle holes 120 provided in the substrate unit 110, or a plurality of needle holes. It may have a size or area that may include some of the 120.
  • FIGS. 10 and 11 have a size or an area in which the drug storage unit 180 may include some of the needle holes 120 of the plurality of needle holes 120 formed in the substrate unit 110. It is shown to be provided on the substrate portion 110 as it is.
  • an opening of the drug storage unit 180 provided to protrude to the outside of the patch 140 may include the entire number of the needle holes 120 provided in the substrate unit 110. It is shown that the state provided in the substrate unit 110 with a. That is, the drug storage unit 180 may be provided in the substrate unit 110 having a substantially regular hexagonal shape, and a plurality of drug storage units 180 may be provided in one side opening formed by the drug storage unit 180. All needle holes 120 may be disposed.
  • the multi-type microneedle of the present invention can be sold and used in various industrial fields, such as the medical field and the skin care field.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)

Abstract

La présente invention comprend : une partie de substrat; de multiples trous d'aiguille agencés sur la partie de substrat; de multiples parties d'aiguille agencées à des intervalles réguliers le long de la direction circonférentielle de chacun des trous d'aiguille au niveau d'une partie de la partie de substrat définissant les trous d'aiguille; et un timbre à mettre en contact avec la peau d'un utilisateur tout en étant en contact avec une surface de la partie de substrat. En outre, la présente invention comprend une partie d'injection de médicament ou une partie de stockage de médicament capable de fournir de plus un médicament, et est configurée de telle sorte que les multiples parties d'aiguille sont agencées selon un motif prédéterminé autour d'un trou d'aiguille. Par conséquent, les multiples parties d'aiguille peuvent être insérées dans une zone prédéterminée de la peau et permettent ainsi d'obtenir une diffusion ou une perméation rapide d'un médicament à administrer dans le corps sous la peau. De plus, la présente invention a une structure capable d'ajuster la quantité d'un médicament administré dans le corps et peut ainsi être utilisée de manière adaptative en fonction de la préférence de l'utilisateur ou de l'état d'un patient.
PCT/KR2019/003717 2018-03-30 2019-03-29 Micro-aiguille multi-type WO2019190267A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US17/041,445 US20210016070A1 (en) 2018-03-30 2019-03-29 Multi-type microneedle
CN201980023213.7A CN111918691B (zh) 2018-03-30 2019-03-29 多功能型微针
JP2020552210A JP7125998B2 (ja) 2018-03-30 2019-03-29 マルチ型マイクロニードル

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2018-0037037 2018-03-30
KR20180037037 2018-03-30
KR10-2019-0034533 2019-03-26
KR1020190034533A KR102291392B1 (ko) 2018-03-30 2019-03-26 멀티형 마이크로 니들

Publications (1)

Publication Number Publication Date
WO2019190267A1 true WO2019190267A1 (fr) 2019-10-03

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PCT/KR2019/003717 WO2019190267A1 (fr) 2018-03-30 2019-03-29 Micro-aiguille multi-type

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WO (1) WO2019190267A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113784745A (zh) * 2020-04-09 2021-12-10 株式会社艾莫克尔 具有球形滚针的拆装式皮肤手术装置
WO2022012520A1 (fr) * 2020-07-13 2022-01-20 Icreate Technology (Zhuhai) Co., Ltd. Réseau de micro-aiguilles et capteur le comprenant

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060108682A (ko) * 2003-10-24 2006-10-18 알자 코포레이션 경피 약물 전달을 증대시키기 위한 전처리 방법 및 장치
KR20070011481A (ko) * 2004-04-13 2007-01-24 알자 코포레이션 다중 백신의 경피 전달용 기구 및 방법
KR20080030553A (ko) * 2005-04-25 2008-04-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 각질층 관통 장치를 사용한 좌창 치료 방법
JP2012532709A (ja) * 2009-07-15 2012-12-20 デバイオテック・ソシエテ・アノニム 多チャンネル・マイクロニードル
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
WO2018124808A1 (fr) * 2016-12-29 2018-07-05 랩앤피플주식회사 Micro-aiguille

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060108682A (ko) * 2003-10-24 2006-10-18 알자 코포레이션 경피 약물 전달을 증대시키기 위한 전처리 방법 및 장치
KR20070011481A (ko) * 2004-04-13 2007-01-24 알자 코포레이션 다중 백신의 경피 전달용 기구 및 방법
KR20080030553A (ko) * 2005-04-25 2008-04-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 각질층 관통 장치를 사용한 좌창 치료 방법
JP2012532709A (ja) * 2009-07-15 2012-12-20 デバイオテック・ソシエテ・アノニム 多チャンネル・マイクロニードル
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
WO2018124808A1 (fr) * 2016-12-29 2018-07-05 랩앤피플주식회사 Micro-aiguille

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113784745A (zh) * 2020-04-09 2021-12-10 株式会社艾莫克尔 具有球形滚针的拆装式皮肤手术装置
CN113784745B (zh) * 2020-04-09 2023-09-15 株式会社艾莫克尔 具有球形滚针的拆装式皮肤手术装置
WO2022012520A1 (fr) * 2020-07-13 2022-01-20 Icreate Technology (Zhuhai) Co., Ltd. Réseau de micro-aiguilles et capteur le comprenant
CN114190076A (zh) * 2020-07-13 2022-03-15 怀德创建科技(珠海)有限公司 显微操作针阵列和包括其的传感器

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