WO2019190267A1

WO2019190267A1 - Multi-type microneedle

Info

Publication number: WO2019190267A1
Application number: PCT/KR2019/003717
Authority: WO
Inventors: 조성윤; 추현욱; 정우진
Original assignee: 랩앤피플주식회사
Priority date: 2018-03-30
Filing date: 2019-03-29
Publication date: 2019-10-03

Abstract

The present invention comprises: a substrate part; multiple needle holes arranged on the substrate part; multiple needle parts arranged at regular intervals along the circumferential direction of each of the needle holes at a portion of the substrate part defining the needles holes; and a patch to be brought into contact with a user's skin while being in contact with one surface of the substrate part. Further, the present invention comprises a drug injection part or drug storage part capable of additionally supplying a drug, and is configured such that the multiple needle parts are arranged in a predetermined pattern around one needle hole. Therefore, the multiple needle parts can be inserted into a predetermined area of the skin and thus can achieve rapid diffusion or permeation of a drug to be delivered into the body under the skin. Moreover, the present invention has a structure capable of adjusting the amount of a drug delivered into the body and thus can be adaptively used according to a user's preference or a patient's condition.

Description

Multi Type Micro Needle

FIELD OF THE INVENTION The present invention relates to multi-type microneedles, and more particularly, to microneedle patches that adhere to the skin and deliver substances such as drugs subcutaneously.

Drug delivery system (DDS) refers to a series of technologies for delivering a substance having pharmacological activity to cells, tissues, organs and organs using various physicochemical techniques.

As the drug delivery system, the oral administration method of ingesting the drug by mouth is most commonly used, and there are transdermal penetration methods such as delivering the drug to a part of the human body. Among them, a method of delivering a liquid drug by punching a hole in a patient's skin with a metal injection needle, that is, a drug delivery method using a syringe has been widely used for a long time.

However, the drug delivery method using a syringe causes pain in the patient during the injection of the drug, and also may cause an infection in the patient due to the re-use of the needle due to the hassle of repeated vaccination and the neglect of managing the syringe. have.

In addition, the above method has a disadvantage in that the patient cannot administer the drug by using a syringe because an inoculator with knowledge of using a syringe is required.

Therefore, in recent years, in order to improve a drug delivery method using a syringe, a micro-sized transdermal penetration microneedle much smaller than a pen-type syringe has been manufactured and utilized.

The microneedle is a system that delivers a drug by physically drilling a small hole in the stratum corneum. In 1998, the Frausnicks Group of Georgia Institute of Technology, Georgia, made a microneedle array using silicon process technology and suggested the possibility of drug delivery. Many researches are being actively conducted at the beginning, and are made in various sizes and shapes based on various materials such as metal, polymer, glass and ceramic as well as silicon.

In addition, microneedles are used for the delivery of active substances such as drugs and vaccines in vivo, detection of bioanalytes in the body, and biopsy, and injection of other skin cosmetics or drugs into skin tissue or from the inside of the skin. It is also used for the purpose of extracting the same body fluids. Therefore, microneedles can be said to be one of the drug delivery methods that are very rapidly used in various fields since local needle injection is possible locally and minimizes pain when inserted into the skin.

However, the microneedle of the polymer material of the existing microneedles does not penetrate into the stratum corneum of the skin as a body has a physical property limitation that does not diffuse the drug smoothly into the body. In order to solve this problem, the inventors of the present invention have proposed a number of technical descriptions of microneedles using a biodegradable metal material, which increases the rigidity of the metal material to increase penetration into the stratum corneum, and additionally benefits the human body.

That is, as shown in FIG. 1, the microneedle 10 is an initial form of the biodegradable metal solid microneedle, and has a high penetration force into the stratum corneum, thereby enhancing the drug delivery effect.

However, as shown, it consists of a substrate portion 1 attached to the skin and a needle 2 protruding from the substrate portion 1 and inserted into the skin, so that the needles 2 are spaced apart on the substrate portion 1 by a predetermined distance. Since it has a simple structure arranged in a plurality of matrices, it is not an advantageous structure for supporting or passing the drug to be delivered to the microneedle, such as drug coating or drug injection from the upper part, and thus, increases the penetration efficiency of the needle itself. On the contrary, there is a disadvantage in that no suitable means for delivering the drug to the transdermal is provided.

Accordingly, recently, methods for enhancing transdermal drug delivery using chemical enhancers, iontophoresis, electroporation, ultrasound, and thermal devices have been steadily developed to improve drug delivery speed. However, this not only complicates the manufacturing process of the microneedle, but also increases the manufacturing cost thereof. In addition, there are many problems that are not suitable according to the form of the drug and also cause side effects on the skin.

In addition, the substrate portion 1 of the microneedle 10 is generally manufactured using a mold, and the substrate portion 1 manufactured by a mold method is pressed by a press in a post process. Then, the plurality of needles 2 formed on the substrate portion 1 may be pressed by the press and bent and protruded on the substrate portion 1.

However, since the microneedle 10 shown in FIG. 1 has a structure in which a plurality of needles 2 are arranged at a predetermined interval on the substrate portion 1 as described above, a plurality of microneedles 10 have a complex structure. A movable mold, ie, a movable mold having a pressing piece which is in correspondence with each of the plurality of needles 2, is to be mounted.

In addition, when pressing the plurality of needles 2 with the press equipped with the movable mold as described above, a portion of the substrate portion 1 disposed between the plurality of needles 2 is deformed or damaged due to the pressure pieces. There is a problem.

In particular, when the number of needles 2 is increased to increase the delivery rate of the drug delivered subcutaneously, the substrate portion disposed between the plurality of needles 2 is rather narrowed when the spacing between the needles 2 is narrowed. As the part of 1) is disposed closer to the pressing piece, it may be easily deformed or broken.

Therefore, the present applicant has been proposed the present invention to solve the above problems, the related prior art documents, the Republic of Korea Patent Publication No. 10-2014-0105686 'for stimulating the pain area or acupuncture points of the body Microneedle patch '.

The present invention is to solve the above problems, the drug to be delivered to the user's body can be quickly penetrated or diffused, and also before the adhered to the skin or even after the amount of drug to be delivered to the body It is an object to provide a multi-type microneedle configured to be easily adjusted as needed.

The present invention, the substrate portion; Needle holes provided in a plurality in the substrate portion; Needle parts provided in a plurality at predetermined intervals along the circumferential direction of the needle ball at a portion of the substrate part that divides the needle ball; And a patch in contact with the skin of the user while being in contact with one surface of the substrate unit.

In addition, the patch may be provided with a drug inlet for the drug to be delivered into the body.

In addition, the drug injection portion may be provided on the patch in the form of an opening connected to communicate with a plurality of needle holes provided in the substrate portion.

In addition, at least one drug injection unit may be provided in the substrate unit.

In addition, the substrate unit may be provided with a drug storage unit for storing the drug to be delivered into the body.

In addition, the drug reservoir may be interposed between the substrate portion and the patch in the form of an absorbent pad.

In addition, the drug storage unit is made of a non-absorbent material and interposed between the substrate portion and the patch, it may have an annular ring shape.

In addition, the drug storage unit may have a form protruding outward on the patch while forming a predetermined space in which the drug may be stored.

In addition, the drug storage unit is provided to protrude to the outside of the patch while forming the space portion, one side of the storage member having an open form so that the drug flow; And a connecting member integrally connected to one side circumferential surface of the storage member and interposed between the substrate portion and the patch.

In addition, the blocking member for blocking the open one side of the storage member; may further include a.

In addition, the storage member may protrude in a shape having a hemispherical cross section on the patch or protrude in a shape having a cross-section of a 'c' shape.

In addition, the opening formed at one side of the storage member may include an entirety of the plurality of needle holes provided in the substrate portion or may have an area including some of the plurality of needle holes provided in the substrate portion.

In addition, the drug storage unit may be provided in the substrate unit in a plurality of numbers.

In addition, the needle hole may be provided in the substrate portion in the form of a circular or regular polygon.

In addition, when the needle hole is formed in the shape of a regular polygon, the needle part may be provided at the center of the inner side of the substrate part that divides the needle hole.

In addition, one end of the needle portion may be connected to a portion of the substrate portion that partitions the needle hole, and the other end may protrude from the other surface of the substrate portion and be inserted into the user's skin.

In addition, the needle portion or the substrate portion may include a supporting groove for providing a path for the drug flow.

In addition, the supporting groove may be provided on one surface or the other surface of the substrate portion, and one end in the longitudinal direction may be connected to a portion of the area formed by the substrate portion, and the other end in the longitudinal direction may extend toward the other end of the needle portion.

In addition, the support groove may further include a slit groove connected to communicate from the other end in the longitudinal direction of the needle portion to the tip.

In addition, a supporting hole may be formed in a portion of the substrate portion or the needle portion in which the supporting groove is formed along a direction in which the supporting groove is formed.

In addition, when the needle hole is provided in the form of a regular hexagon, the substrate portion may have a honeycomb structure.

In addition, the substrate portion or the needle portion may be formed of a bioabsorbable metal.

In addition, the bioabsorbable metal may be a metal including at least one component of magnesium, calcium, zinc and iron.

The multi-type microneedle according to an embodiment of the present invention has a configuration in which a plurality of needle portions are provided in a predetermined pattern around one needle hole, so that a plurality of needle portions are inserted into a predetermined area of skin to deliver a drug to be delivered to the body. Can spread or penetrate quickly subcutaneously.

In addition, since the multi-type microneedle according to an embodiment of the present invention has a structure that can control the amount of drug delivered to the body through the drug inlet or the drug reservoir, the microneedle may be used in response to a user's preference or patient's condition. Can be.

In addition, the multi-type microneedle according to an embodiment of the present invention has a structure that can adjust the amount of the drug delivered to the body before or after being attached to the skin, it is easy to the physical condition of the user It can be used correspondingly.

In addition, the multi-type microneedle according to an embodiment of the present invention, since the substrate portion may have a honeycomb structure by a needle hole formed in the shape of a regular hexagon, the substrate portion is deformed or damaged by a press in the press pressing process to bend the needle portion Can be minimized.

In addition, the multi-type microneedle according to an embodiment of the present invention can protrude a plurality of needle parts on the substrate portion without providing the number of the pressing pieces provided in the movable mold of the press equal to the number of the needle portion, the movable mold of the press As a result, manufacturing costs can be reduced, thereby reducing the manufacturing cost of microneedles and simplifying the manufacturing process.

1 is a perspective view of a conventional microneedle.

2 is a perspective view of a multi-type microneedle according to an embodiment of the present invention.

3 is an exploded perspective view of the multi-type microneedle shown in FIG.

4 is a plan view of the multi-type microneedle shown in FIG.

5 is a rear view of the multi-type microneedle shown in FIG.

6 is a perspective view of a multi-type microneedle provided with a drug storage unit according to an embodiment of the present invention.

FIG. 7 is an exploded perspective view of the multi-type microneedle shown in FIG. 6. FIG.

8 is a perspective view of a multi-type microneedle provided with a drug reservoir according to another embodiment of the present invention.

9 is an exploded perspective view of the multi-type microneedle shown in FIG. 8.

10 is a perspective view of a multi-type microneedle provided with a drug reservoir according to another embodiment of the present invention.

FIG. 11 is a cross-sectional view of the drug reservoir shown in FIG. 10. FIG.

Figure 12 is a perspective view of the drug reservoir consisting of a storage member having a cross-section of the '' '.

Figure 13 (a) is a perspective view showing a state in which the drug storage unit shown in Figure 8 is provided in the substrate portion of another form.

FIG. 13B is a cross-sectional view of the multi-type microneedle shown in FIG. 13A.

Figure 14 (a) is a perspective view showing a state in which the drug storage unit shown in Figure 10 is provided in the substrate portion of another form.

FIG. 14B is a cross-sectional view of the multi-type microneedle shown in FIG. 14A.

Advantages and features of the present invention and methods for achieving them will be apparent with reference to the embodiments described below in detail with the accompanying drawings.

However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, only the present embodiments to make the disclosure of the present invention complete, and common knowledge in the art to which the present invention pertains. It is provided to fully inform the person having the scope of the invention, which is defined only by the scope of the claims.

Hereinafter, the multi-type microneedle according to an embodiment of the present invention will be described in detail with reference to FIGS. 2 to 12. In describing the present invention, specific descriptions of related well-known functions or configurations are omitted in order not to obscure the subject matter of the present invention.

2 to 12, the multi-type micro needle 100 according to an embodiment of the present invention, the substrate portion 110, the needle hole 120 is provided in a plurality in the substrate portion 110 And a plurality of needle parts 130 and the substrate part provided at a predetermined interval from each other along the circumferential direction of the needle hole 120 at a portion of the substrate part 110 partitioning the needle hole 120. It may include a patch 140 in contact with the skin of the user while being in contact with one surface of the 110.

The substrate unit 110 may have a shape of a thin metal plate having a predetermined area and thickness, and one surface thereof may contact the patch 140 and the other surface may contact the user's skin. .

In addition, the substrate 110 may be manufactured in various shape sizes and shapes corresponding to the skin portion to be attached, and the periphery thereof may be formed to have various curvatures so as to be in airtight contact with the curved skin portion. Can be. For example, when the substrate 110 is attached to the nose portion of the user may be manufactured in the form of a known nose pack.

In addition, the substrate 110 may be loaded with a drug to be delivered subcutaneously. As a method of supporting the drug on the substrate unit 110, a method of dipping the substrate unit 110 in a container in which the drug is stored and coating or coating the drug by applying the drug to the substrate unit 110 is known. Manner may be used.

For reference, the drug contained in the substrate 110 may be a drug for the purpose of preventing and treating diseases, but is not limited thereto. EGF (Epidermal Growth Factor: epidermal growth factor) for genetic material or skin beauty Or hyaluronic acid.

The needle hole 120 is a component that can be formed by processing the substrate unit 110 by a known laser cutting device or etching molding, and as described above, the needle hole 120 is formed on each other on the surface of the substrate unit 110. It can be provided in plural at regular intervals.

The needle hole 120 may be formed in the substrate part 110 in a circular or regular polygonal shape.

As illustrated in FIGS. 4 and 5, the needle part 130 may be provided on an inner side surface of the substrate part 110 that partitions the needle hole 120. In this case, when the needle hole 120 is formed in the shape of a regular polygon, the needle part 130 may be provided at the center of the inner side of the substrate part 110 partitioning the needle hole 120. .

That is, one end in the longitudinal direction of the needle part 130 may be connected to a portion of the substrate part 110 that defines the needle hole 120, and the other end in the longitudinal direction may extend toward the center of the needle hole 120. have.

Here, as shown in FIG. 4, the needle part 130 may be bent and protruded vertically on the other surface of the substrate part 110 by a pressing process using a molding process or a press device. That is, the needle part 130 may be referred to as a component that is inserted under the user's skin when the substrate part 110 contacts the skin of the user and delivers the drug contained in the substrate part 110 and itself. In addition, the drug injected into the drug injecting unit 150 to be described later may also be referred to as a component to be delivered to the subcutaneous of the user.

Meanwhile, a supporting groove 133 may be further provided in the needle part 130 and the substrate part 110.

The supporting groove 133 is provided on one surface or the other surface of the substrate unit 110, one end in the longitudinal direction of which is disposed in a portion of the area formed by the substrate unit 110, and the other end in the longitudinal direction of the needle unit 130. ), That is, extends toward the other end in the longitudinal direction of the needle part 130.

The supporting groove 133 may be selectively provided on one surface or the other surface of the substrate unit 110. In an embodiment of the present invention, the supporting groove 133 is provided on both one surface and the other surface of the substrate unit 110. Is shown.

The supporting groove 133 as described above not only forms a path through which the drug supported on the substrate unit 110 or the needle unit 130 can flow, but also the substrate unit 110 or the needle unit 130. ) Provides a space for the drug to be stored so that the amount of drug delivered to the body can be controlled.

In addition, the supporting groove 133 may have a form in which the inner diameter gradually decreases toward the thickness direction of the substrate portion 110 or the needle portion 130.

The supporting groove 133 configured as described above may be formed by increasing the planar area of the substrate 110 or the needle 130 according to the shape of the drug supported on the substrate 110 or the needle 130. In addition to allowing the amount to be adjusted, a flow path may be provided so that the drug supported on the substrate portion 110 or the needle portion 130 can be easily delivered subcutaneously.

In other words, when the needle part 130 having only a flat surface without a structure such as the supporting groove 133 along the drug delivery path is inserted into the skin, the plate surface of the skin and the needle part 130 is in close contact with each other so that the drug is hard to flow. While forming the structure, as the substrate portion 110 and the needle portion 130 on which the supporting groove 133 is formed are in contact with the skin of the user, when the needle portion 130 is inserted into the skin, the supporting groove ( Drugs stored in 133) can be easily delivered and diffused into the body. In addition, the drug supported on the substrate unit 110 or the needle unit 130 may flow along the forming direction of the supporting groove 133 to be delivered subcutaneously.

In addition, the multi-type micro needle 100 according to an embodiment of the present invention, from the other end in the longitudinal direction of the supporting groove 133, the tip of the needle portion 130, that is, the other end in the longitudinal direction of the needle 130 It may further include a slit groove 134 is communicatively connected to.

The slit groove 134 serves to allow the drug stored in the supporting groove 133 or the supporting hole 135 to be described later to easily flow to the tip of the needle part 130, and thus, the Drugs contained in the substrate 110 or the needle 130 may be more easily delivered to the user's subcutaneous via the supporting groove 133 and the slit groove 134.

Meanwhile, a supporting hole 135 may be further provided in the supporting groove 133. That is, the supporting hole 135 may be formed in a portion of the substrate portion 110 or the needle portion 130 on which the supporting groove 133 is formed along the direction in which the supporting groove 133 is formed.

The supporting hole 135 connects one surface and the other surface of the substrate portion 110 or one surface and the other surface of the needle portion 130 to communicate with each other, and thus, the substrate portion 110 or the needle portion 130. Drugs carried on one side or the other side of the) can communicate with each other so that the drug can quickly spread in the user's skin.

In addition, since the supporting hole 135 provides a space in which the drug can be stored similarly to the supporting groove 133, the amount of the drug supported on the substrate 110 or the needle 130 is controlled. To be possible. That is, the needle hole 135 may be formed in a form in which the inner diameter gradually decreases from one surface of the needle portion 130 or the substrate portion 110 to the other surface direction or from the other surface to one surface direction. The drug coating layer formed to be supported on the 130 may be provided to accommodate a space.

Multi-type micro needle 100 according to an embodiment of the present invention configured as described above, the needle portion 130 has a configuration provided in plurality at regular intervals on the needle hole 120 formed on the substrate portion 110 Therefore, the drug to be supplied into the body can be delivered intensively subcutaneously and rapidly spread.

In addition, when the needle hole 120 is formed in the shape of a regular hexagon, the substrate 110 may have a honeycomb structure. The substrate unit 110 having a honeycomb structure presses the needle hole 120 in the process of pressing the pressing portion of the press to bend the plurality of needle portions 130 arranged around the needle hole 120. Deformation or breakage of the portion 110a (see FIG. 1) of the substrate portion 110 to be partitioned by the pressing piece can be prevented.

In more detail, in the process of inserting the pressing piece provided in the movable mold of the press into the needle hole 120 to bend by pressing the needle unit 130, at this time, between the plurality of needle holes 120 The portion 110a (see FIG. 1) of the substrate portion 110 disposed at the portion may be deformed or torn by being affected by the pressing piece 110.

However, the substrate unit 110 may be formed in a honeycomb structure by providing the multi-type microneedle 100 and the needle hole 120 in the form of a regular hexagon according to an embodiment of the present invention. The overall strength of the 110 may be increased to prevent deformation or breakage of the substrate 110 in a work process using a press.

In addition, the plurality of needle parts 130 may be bent and protruded on the substrate part 110 by one pressing piece inserted into one needle hole 120. Therefore, it is not necessary to provide the number of the pressing pieces provided in the movable mold of the press to the number corresponding to the number of the needle portion 130, so that the structure of the movable mold can be simplified as a whole. Since the manufacturing cost of the mold is reduced, the manufacturing cost of the multi-type microneedle 100 may be reduced and the manufacturing process may be simplified.

On the other hand, the multi-type micro needle 100 according to an embodiment of the present invention, may be formed of a bioabsorbable metal. That is, the substrate unit 110 or the needle unit 130 may be formed of a bioabsorbable metal composed of components beneficial to the human body.

That is, the substrate unit 110 may be made of a metal including at least one component of magnesium, calcium, zinc, and iron, which are utilized as bioabsorbable metals. Accordingly, the needle provided on the substrate unit 110 may be used. The part 130 is also made of a bioabsorbable metal.

For reference, bioabsorbable metals are made of magnesium-based alloys for application as orthopedic implants, and are commercially available both at home and abroad. The focus was on slowing speed as much as possible or improving corrosion resistance.

However, unlike the bioabsorbable metal applied to orthopedic surgery, the bioabsorbable metal forming the multi-type microneedle 100 according to an embodiment of the present invention accelerates the decomposition rate in the body to supply minerals with subcutaneous drug release. Possible mechanisms can be applied.

For example, magnesium, calcium, and zinc, which are utilized as bioabsorbable metals, have a mechanism of reacting with water to release hydrogen gas and decomposing as shown in the following [Formula 1] to [Formula 3].

The substrate 110 and the needle 130 formed of the bioabsorbable metal as described above release ions and decomposition products under the skin, and the hydrogen gas generated by the by-products provides a swelling effect within the skin to improve wrinkles. Can be derived.

In addition, the by-products ZnO and MgCl, which are produced by inserting magnesium and zinc, which are components of the bioabsorbable metal, into the living body, remain on the skin surface subcutaneously, and the drugs supported by the substrate 110 and the needle 130 are subcutaneously. It may also play the role of a drug delivery enhancer to enhance absorption. Therefore, the substrate unit 110 and the needle unit 130 formed of a bioabsorbable metal can effectively deliver the drug supported thereon to the user.

On the other hand, the shape of the needle hole 120 and the needle portion 130 formed in the substrate portion 110 is patterned on the substrate portion 110 by a known lithography or etching technique. Can be formed.

In this case, since the substrate portion 110 formed of the bioabsorbable metal has lower corrosion resistance than metal such as metal, for example, stainless steel or iron, the edge of the needle portion 130 may be formed by the lithography or etching technique. It may have a sharp shape that is corroded and thinner than the thickness of the raw material itself so that it can be easily inserted subcutaneously.

In addition, since the multi-type micro needle 100 according to an embodiment of the present invention includes a needle hole 120 having a relatively large diameter or a larger area than a needle hole formed in a conventional micro needle, the user may Through the ball 120, light therapy (light-therapy; phototherapy) can also be received in parallel.

That is, even when the substrate unit 110 is attached to the skin, the user's skin may be exposed to the outside through the plurality of needle holes 120, and thus the exposed skin may be exposed to skin diseases such as skin pain, acne, and atopy. Phototherapy can also be easily performed by irradiating beneficial light.

Therefore, since the user may be treated by the drug injected into the skin through the needle part 130 and the light irradiated through the needle hole 120, the synergy effect of the drug treatment and the phototherapy can be expected. have.

For reference, in the exemplary embodiment of the present invention, the light exposed to the human body is irradiated to the skin exposed through the needle hole 120, but it has been described as being able to receive a light therapy procedure, but is not limited thereto. That is, the skin treatment material or skin treatment material may be applied to the skin exposed through the needle hole 120 to perform a skin treatment procedure.

The patch 140 is a component for bringing the other surface of the substrate unit 110 into close contact with the user's skin, and may be attached to one surface of the substrate unit 110 as described above.

The patch 140 may be attached to one surface of the substrate unit 110 while having a larger area than that formed by the substrate unit 110, and may be adhered to a surface facing one surface of the substrate unit 110. It is made of a material that is coated with a substance or has good adhesion to skin.

A portion of the patch 140 that is not in contact with the substrate 110 may be referred to as a portion that is attached to the skin of the user. Accordingly, the substrate 110 may be prevented from flowing in the skin of the user. .

In addition, the patch 140, the drug input unit 150 that provides a path through which the drug can be injected into one surface side of the substrate unit 110 while the other surface of the substrate unit 110 is in contact with the user's skin. May be provided.

2 and 3, the drug injector 150 is formed on the patch 140 in the form of an opening connected to communicate with a plurality of needle holes 120 provided in the substrate unit 110. It may be provided in, at least one or more may be provided on the patch 140. In an embodiment of the present invention, two openings are shown in the drawing as being formed in the patch 140 at a predetermined interval from each other.

Thus, the user may additionally apply the drug on the substrate 110 through the drug inlet 150, the drug applied to the substrate 110 is the needle hole 120 and the needle It may be delivered to the subcutaneous of the user via the unit 130.

For reference, a method of injecting the drug into the drug injector 150 may be made through a drug supply device having a syringe, and may also be made through an ampule container in which a drug is stored. In addition, a method of adding a sheet impregnated with the drug may be applied.

That is, the user may additionally supplement the substrate unit 110 with a drug stored in an ampoule container or a syringe, a drug impregnated in a sheet, and the like, in addition to the drug primarily supported on the substrate unit 110.

Therefore, even if the drug primarily supported on the substrate unit 110 is dried or subcutaneously consumed and consumed, the substrate unit 110 can be maintained on the skin without removing the substrate unit 110. Multi-type microneedle 100 of the present invention has the advantage that can be used for a long time.

6 and 7, the substrate unit 110 may further include a drug storage unit 160 storing a drug to be delivered to the user's body.

The drug storage unit 160 may be interposed between one surface of the substrate unit 110 and the patch 140 in the form of an absorbent pad.

The absorbent pad may be made of a material such as a sponge, cotton, cotton, polyurethane, etc., which can hold a liquid material for a long time. For reference, in the exemplary embodiment of the present invention, two absorbent pads having a circular shape are provided on one side of the substrate unit 110 and the patch 140 at a predetermined interval from each other. However, the present invention is not limited thereto and may include at least one on the substrate unit 110.

The drug storage unit 160 as described above is a component that allows the user to additionally supplement the drug through the other surface of the substrate unit 110 before attaching the substrate unit 110 to the user's skin. Can be. That is, the user may additionally supply the drug to the other surface of the substrate unit 110 by using the above-described syringe or ampoule container, wherein the supplied drug is provided between one surface of the substrate unit 110 and the patch 140. It may be absorbed in the drug reservoir 160 interposed.

Therefore, the user may increase or decrease the amount of the drug to suit his or her preference before attaching the substrate 110 to the skin, and when the multi-type microneedle 100 is used for a patient for medical purposes, There may be a doctor or a nurse to adjust the supply of the drug through the drug storage unit 160 according to the condition of the patient.

For reference, when the drug storage unit 160 is provided in the substrate unit 110, it is preferable that the drug input unit 150 is not formed in the patch 140. This is because the drug absorbed in the drug storage unit 160 may be easily evaporated by wind or air flowing through the drug inlet unit 150.

In addition, the drug storage unit 160 having an absorbent pad shape may have a size or an area that may include the entirety of the plurality of needle holes 120 provided in the substrate unit 110, or a plurality of needle holes ( It may have a size or area that may include some of the 120). For reference, FIGS. 6 and 7 have a size in which the drug storage unit 160 having an absorbent pad shape may include some needle holes 120 among the plurality of needle holes 120 formed in the substrate unit 110. Or it is shown to be provided on the substrate portion 110 with an area.

8 and 9, a drug storage unit 170 according to another embodiment of the present invention will be described.

As shown in Figure 8 and 9, the drug storage unit 170 according to another embodiment of the present invention, is made of a non-absorbent material is interposed between one surface of the substrate portion 110 and the patch, annular It may have a ring shape.

The non-absorbent material may be made of a thermoplastic material such as polyethylene. For reference, in one embodiment of the present invention, two non-absorbent materials having an annular annular shape are provided between one surface of the substrate unit 110 and the patch 140 at a predetermined interval from each other. It is shown on the figure.

The drug storage unit 170 made of the non-absorbent material as described above, rather than the point of absorbing and storing the drug, partitions the space where the drug supplemented by the user can be stored to concentrate the drug in the skin area of the user In addition, the drug injected from the syringe or the ampoule container may be prevented from leaking out of the area formed by the substrate unit 110 to penetrate the patch 140.

In other words, since the drug storage unit 170 made of the non-absorbent material is provided on the substrate unit 110 in the form of a ring, the user may use the syringe or the ampoule container to form the inside of the drug storage unit 170. When the drug is additionally supplied, the supplied drug may be stored in an internal space partitioned by the drug storage unit 170.

For reference, when the drug storage unit 170 made of a non-absorbent material is provided in the substrate unit 110, it is preferable that the drug input unit 150 is not formed in the patch 140. This is because the drug absorbed in the drug storage unit 170 may be easily evaporated by wind or air flowing through the drug inlet unit 150.

In addition, the ring-shaped drug storage unit 170 is made of a non-absorbent material, has a size or area that can include the entire number of the needle hole 120 provided in the substrate portion 110, or It may have a size or area that may include a portion of the dog needle hole (120). For reference, FIGS. 8 and 9, the drug storage unit 170 having a ring shape made of a non-absorbent material may have a portion of the needle holes 120 of the plurality of needle holes 120 formed in the substrate unit 110. It is shown to be provided on the substrate portion 110 with a size or area that can be included.

For reference, in FIG. 13, the ring-shaped drug storage unit 170 made of a non-absorbent material has a size or area that may include the entire number of the needle holes 120 provided in the substrate unit 110. The state provided in the substrate unit 110 is shown. That is, the drug storage unit 170 may be provided in the substrate 110 having a substantially regular hexagonal shape, and a plurality of needles provided in the substrate unit 110 in a space partitioned by the drug storage unit 170. All of the balls 120 may be placed.

10 and 11, a drug storage unit 180 according to another embodiment of the present invention will be described.

10 and 11, the drug storage unit 180 according to another embodiment of the present invention protrudes outward on the patch 140 while forming a predetermined space in which drugs can be stored. It may have a form. That is, the drug storage unit 180 according to another embodiment of the present invention, may be provided in the saik substrate unit 110 while having a form that the user can press the hand.

The drug storage unit 180 is provided to protrude to the outside of the patch 140 while forming the space portion, one side of the storage member 181 having an open shape to allow the drug flow; And a storage member 183 integrally connected to one side circumferential surface of the storage member 181 and interposed between the substrate unit 110 and the patch 140.

The storage member 181 may be referred to as a component that provides a space in which the drug is stored and is pressed by the user's hand. As illustrated in FIGS. 10 and 11, the storage member 181 may be provided on the substrate 110 in a shape having a hemispherical cross section to protrude out of the patch 140.

The storage member 181 may have various forms without being limited to the hemispherical shape described above, as long as it forms a space in which the drug can be stored and can be easily pressed by the user's hand. Of course. For example, as shown in Figure 12, it may be provided on the substrate portion 110 in the form having a '' 'cross-section.

Here, a through hole is formed in a portion of the patch 140 corresponding to the storage member 181 so that the storage member 181 protrudes out of the patch 140 to be pressed by a user's hand. Can be.

The storage member 183 may be referred to as a component bonded to one surface of the substrate unit 110, and may be interposed between the substrate unit 110 and the patch 140 as described above.

As described above, the drug storage unit 130 according to another embodiment of the present invention composed of the storage member 181 and the storage member 183 may be made of a transparent thermoplastic resin, a film material.

The drug storage unit 180 as described above allows the user to supplement the drug through the other surface of the substrate unit 110 before the user attaches the substrate unit 110 to the skin. That is, the user may additionally supply the drug to the space portion formed by the storage member 180 through the other surface of the substrate unit 110 using the above-described syringe or ampoule container.

Therefore, the user may increase or decrease the amount of the drug to suit his or her preference before attaching the substrate 110 to the skin, and when the multi-type microneedle 100 is used for a patient for medical purposes, There may be a doctor or a nurse to adjust the supply of the drug through the drug storage unit 180 according to the condition of the patient.

On the other hand, as shown in Figure 11, the open side of the storage member 181 so that the drug stored in the storage member 181 can be leaked on the storage member 181 only when the user presses by hand It may be blocked by the blocking member 182.

That is, one side open to the storage member 181 may be blocked by the blocking member 182 so that the user can selectively use the drug stored in the storage member 181. Accordingly, when the user presses the storage member 181 by hand, the blocking member 182 may be torn due to the pressure, and the drug stored in the storage member 181 may flow out onto the substrate 110.

Accordingly, the drug storage unit 180 of another embodiment of the present invention may be used in a manner in which the user supplements the storage member 181 using a syringe or ampoule container, or a package in which the drug is already stored. The substrate unit 110 may be provided to be used.

The opening formed at one side of the drug storage unit 180 may have a size or an area that may include the entire plurality of needle holes 120 provided in the substrate unit 110, or a plurality of needle holes. It may have a size or area that may include some of the 120. For reference, FIGS. 10 and 11 have a size or an area in which the drug storage unit 180 may include some of the needle holes 120 of the plurality of needle holes 120 formed in the substrate unit 110. It is shown to be provided on the substrate portion 110 as it is.

For reference, in FIG. 14, an opening of the drug storage unit 180 provided to protrude to the outside of the patch 140 may include the entire number of the needle holes 120 provided in the substrate unit 110. It is shown that the state provided in the substrate unit 110 with a. That is, the drug storage unit 180 may be provided in the substrate unit 110 having a substantially regular hexagonal shape, and a plurality of drug storage units 180 may be provided in one side opening formed by the drug storage unit 180. All needle holes 120 may be disposed.

While specific embodiments of the present invention have been described so far, various modifications are possible without departing from the scope of the present invention.

Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined not only by the claims below, but also by the equivalents of the claims.

The multi-type microneedle of the present invention can be sold and used in various industrial fields, such as the medical field and the skin care field.

Claims

A substrate portion;

Needle holes provided in a plurality in the substrate portion;

Needle parts provided in a plurality at intervals from each other along the circumferential direction of the needle balls at a portion of the substrate part partitioning the needle balls; And

And a patch in contact with the skin of the user while being in contact with one surface of the substrate portion.
The method of claim 1,

The patch is a multi-type microneedle, characterized in that the drug input unit is provided to the drug to be delivered into the body.
The method of claim 2,

The drug injection unit

The multi-type microneedle, characterized in that provided on the patch in the form of an opening connected to the plurality of needle holes provided in the substrate portion.
The method of claim 3, wherein

Multi-type microneedle, characterized in that provided in the at least one drug inlet portion the substrate portion.
The method of claim 1,

The substrate type is a multi-type micro needle, characterized in that the drug storage unit for storing the drug to be delivered to the body is provided.
The method of claim 5,

And the drug storage portion is interposed between the substrate portion and the patch in the form of an absorbent pad.
The method of claim 5,

The drug storage unit is made of a non-absorbent material, interposed between the substrate portion and the patch, the multi-type microneedle, characterized in that it has an annular ring shape.
The method of claim 5,

The drug storage unit, the multi-type microneedle, characterized in that the form protruding outward on the patch while forming a predetermined space in which the drug can be stored.
The method of claim 8,

The drug storage unit,

A storage member provided to protrude to the outside of the patch while forming the space portion, and one side of the storage member having an open shape to allow a drug to flow; And

And a connection member integrally connected to one side circumferential surface of the storage member and interposed between the substrate portion and the patch.
The method of claim 9,

Multi-type micro needle further comprises a; blocking member for blocking the open one side of the storage member.
The method of claim 9,

The storage member,

The multi-type microneedle, characterized in that protruding in the form having a hemispherical cross section on the patch or in the form having a '' 'shaped cross section.
The method of claim 9,

The opening formed at one side of the storage member may include all of the plurality of needle holes provided in the substrate, or may have an area including some of the plurality of needle holes provided in the substrate. .
The method according to any one of claims 6 to 9,

The drug storage unit is a multi-type microneedle, characterized in that provided in the substrate portion a plurality of numbers.
The method of claim 1,

The needle hole is a multi-type micro needle, characterized in that provided in the substrate portion in the form of a circular or regular polygon.
The method of claim 14,

The needle part is provided in the center of the inner side of the substrate portion for partitioning the needle hole, when the needle hole is formed in the form of a regular polygon.
The method of claim 1,

One end of the needle portion is connected to the portion of the substrate portion partitioning the needle hole and the other end protrudes on the other surface of the substrate portion is a multi-type micro needle characterized in that it is inserted into the user's skin.
The method of claim 16,

And a support groove provided in the needle part or the substrate part to provide a path through which drugs can flow.
The method of claim 17,

The supporting groove is provided on one surface or the other surface of the substrate portion, one end in the longitudinal direction is connected to a portion of the area formed by the substrate portion and the other end in the longitudinal direction extends toward the other end of the needle portion.
The method of claim 18,

The micro-type microneedle further comprises a slit groove connected to communicate from the other end in the longitudinal direction of the supporting groove to the tip of the needle portion.
The method of claim 18,

Multi-type micro needle, characterized in that the supporting hole is formed along the forming direction of the supporting groove in the substrate portion or the needle portion formed with the supporting groove.
The method of claim 14,

The substrate portion, when the needle hole is provided in the form of a regular hexagon, multi-type micro needle characterized in that it has a honeycomb structure.
The method of claim 1,

Multi-type micro needle, characterized in that the substrate portion or the needle portion is formed of a bioabsorbable metal.
The method of claim 22,

The bioabsorbable metal is a multi-type microneedle, characterized in that the metal containing at least one component of magnesium, calcium, zinc, iron.