KR20230153618A - Micro needle patch - Google Patents

Abstract

Microneedle patch is introduced. The microneedle patch according to the present invention includes a patch body; and a plurality of microneedles disposed on the patch body, based on any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part in order to uniform the penetration depth of the plurality of microneedles. The plurality of microneedles are provided at different heights.

Description

Micro Needle Patch {MICRO NEEDLE PATCH}

The present invention relates to a microneedle patch, and more specifically, by using a micro-sized needle that is much smaller than the needle of a regular syringe, it reduces the discomfort and rejection of injections and simultaneously injects drugs for skin care or treatment into the skin tissue. It is about a microneedle patch that can be effectively injected into the body.

As a method for delivering pharmaceutical, medical, or cosmetically effective substances applied to the human body, a method of injecting the active substance in liquid form through a hypodermic needle is widely applied. However, hypodermic needles with a diameter of about a few millimeters can cause pain to the user by stimulating multiple pain points on the skin, so there is a problem that a high level of skill is required to use them.

To overcome these problems with hypodermic injection needles, a method for transdermal delivery of active substances using microneedle patches with diameters and heights of only tens or hundreds of micrometers has been actively studied.

The microneedle patch forms numerous microchannels that penetrate the stratum corneum layer of the skin using a plurality of microneedles. Through the microchannels, a sufficient amount of the active substance can reach the epidermis layer or dermis layer.

Methods for delivering drugs using these microneedles include coating the drug on the surface of the microneedle and filling the inside of the microneedle with the drug. When the drug is filled inside the microneedle, the needle is biodegradable. It is made of a plastic material so that the microneedles penetrate the transdermis, and the filled drug is injected into the skin tissue by dissolving the microneedles in the permeable area.

Unlike conventional injection needles, these microneedles have the advantage of painless skin penetration and no trauma. However, since microneedles must penetrate the stratum corneum of the skin, a certain level of physical hardness may be required. Additionally, an appropriate length may be required for the bioactive substance to reach the epidermal or dermal layer of the skin.

In addition, in order for the effective substances to be accurately spread and delivered into the body, the microneedle patch with microneedles must be properly attached. The microneedle patch must be stably attached to the curved surface of the living body and not be detached from the surface of the living body due to muscle movement.

And while the microneedle is attached to the surface of the living body, it must be maintained within the living body for an appropriate amount of time to deliver the effective substance. In addition, after an appropriate amount of the effective substance is released, it is necessary to prevent unexpected inflammatory reactions by removing the microneedles from the body or allowing the microneedles to biodegrade within the body.

However, in the conventional microneedle patch, a plurality of microneedles are made of substantially the same shape and substantially the same length or height. However, human skin has different thicknesses of the stratum corneum and epidermis for each person, and the thickness of the skin varies depending on the body part, such as the face, and there is a curvature in the body contour, such as the facial contour, so it is not possible to attach a patch with the same needle height. Depending on the area, problems may arise where the microneedle cannot be fully inserted to the desired depth.

That is, according to the conventional microneedle patch, the needle length or height is substantially the same, so for example, there is a problem in that it is relatively difficult for the microneedle to penetrate areas where the skin is thick or has depressions.

In addition, in the conventional microneedle patch, the functional material components coated on the surface between the microneedles have weak adhesion to the skin, so when a large-area microneedle patch is attached to the body, for example, the face, the central portion There is a problem with the microneedle patch falling off the skin because it does not adhere and hold as well as the adhesive layer on the edge. These problems make it difficult to manufacture large-area microneedle patches.

Republic of Korea Patent Publication No. 10-2020-0032461 (2020.03.26.)

The problem to be solved by the present invention is to provide an even and uniform skin penetration depth of the microneedles by providing a plurality of microneedles with different heights based on any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. The goal is to provide a microneedle patch that can secure the skin properly.

In addition, by forming an adhesive layer between microneedles, it is easier to adhere to the skin than before without loosening. In particular, even if the area is large, it can be adhered to the skin more closely than before without loosening, providing a microneedle patch that can be manufactured even in a large area.

According to one aspect of the present invention, the patch body; And a plurality of micro-needles disposed on the patch body, in order to uniform the penetration depth of the plurality of micro-needles, to any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. A microneedle patch may be provided, wherein the plurality of microneedles are provided at different heights based on the present invention.

It further includes at least one needle base supporting the arrangement of the plurality of microneedles, wherein the needle base and the plurality of microneedles are injected into the microneedle mold to cure the DNA and separate from the microneedle mold. It can be prepared in one way.

It is disposed between the patch body and the needle base, and may further include a primary film to which the patch body is coupled to one side and the needle base to the other side.

The primary film may be a needle adhesive doubling film that doubles the adhesion of the needle base to the patch body.

When the needle base is placed on the patch body, an adhesive layer is exposed in the area of the patch body where the needle base is not placed, and a through hole is formed in the area corresponding to the needle base when the needle base is placed for attachment to the patch body. It is provided and may further include a protective release sheet of a size capable of covering the patch body and having at least a portion of the area attached to the adhesive layer to protect the adhesive layer.

Among the plurality of microneedles, at least one microneedle among the microneedles with the maximum height and the microneedles with the minimum height has a difference of more than 20% from the average height of all microneedles, and the plurality of microneedles extend from the central area to the outskirts. It can be arranged so that the height increases as time goes on, or the height increases from one side to the other.

The needle base is provided with a plurality of unit needle bases spaced apart from each other, and when the plurality of unit needle bases are arranged, an adhesive layer is formed in the area of the patch body between the unit needle bases where the unit needle base is not arranged. It can be exposed to form an adhesion improvement area that strengthens adhesion to the skin.

The height of the plurality of microneedles disposed within one unit needle base is substantially the same, but in order to uniform the penetration depth of the plurality of microneedles, the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part are adjusted. Depending on the height of the micro needle for each unit needle base, the height may be different.

The unit needle base may have a predetermined area and may have at least one of a circular shape and a polygonal shape.

It is disposed between the patch body and the unit needle base, and may further include a unit primary film to which the patch body is coupled to one side and the unit needle base to the other side.

The unit primary film may be a unit needle adhesive doubler film that doubles the adhesion of the unit needle base to the patch body.

When disposed for attachment to the patch body, a through hole is provided in an area corresponding to the unit needle base, and is provided in a size that can cover the patch body, so that at least a portion of the area is attached to the adhesion improvement portion to protect the adhesive layer. It may further include a protective release sheet.

Embodiments of the present invention secure the skin penetration depth of the microneedles evenly and uniformly by providing a plurality of microneedles with different heights based on any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. I can do it for you.

In addition, by forming an adhesive layer between the microneedles, it is easier to adhere to the skin than before without loosening. In particular, even if the area is large, it can be manufactured in a large area because it can be adhered to the skin more closely than before without being loose.

In addition, the height of the plurality of microneedles disposed within one unit needle base is substantially the same, but in order to uniform the penetration depth of the plurality of microneedles, the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part are used. By providing different heights of microneedles for each unit needle base, it is possible to solve the problem that it is relatively difficult for microneedles to penetrate areas where the skin is thick or dented.

Figure 1 is a perspective view schematically showing main parts of a microneedle patch according to a first embodiment of the present invention.
Figure 2 is a schematic exploded side view of the microneedle patch according to the first embodiment of the present invention.
Figure 3 is a perspective view schematically showing main parts of the microneedle patch according to the second embodiment of the present invention.
FIGS. 4(a) to 4(c) are diagrams showing modified examples of microneedle height as modified examples of the first and second embodiments of the present invention.
Figure 5 is a perspective view schematically showing main parts of a microneedle patch according to a third embodiment of the present invention.

In order to fully understand the present invention, its operational advantages, and the objectives achieved by practicing the present invention, reference should be made to the accompanying drawings illustrating preferred embodiments of the present invention and the contents described in the accompanying drawings.

Hereinafter, the present invention will be described in detail by explaining preferred embodiments of the present invention with reference to the accompanying drawings. However, in explaining the present invention, descriptions of already known functions or configurations will be omitted to make the gist of the present invention clear.

Figure 1 is a perspective view schematically showing main parts of a microneedle patch according to a first embodiment of the present invention, and Figure 2 is a schematic exploded side view of the microneedle patch according to a first embodiment of the present invention.

As shown in these drawings, the microneedle patch 1 according to this embodiment includes a patch body 10, a plurality of microneedles 20, a needle base 30, and a primary film 40. And, it includes a protective release sheet (50).

The patch body (10) serves as a base for the microneedle patch (1). Materials of the patch body 10 include, for example, hydrocolloid, cellulose resin, polyester resin such as polyethylene terephthalate (PET) and polyethylene naphthalate (PEN), At least one of polyethylene resin, polyvinyl chloride resin, polycarbonate (PC), polyethylene sulfone (PES), polyether ether ketone (PEEK), and polyphenylene sulfide (PPS), or these It can be a combination. In this embodiment, the material of the patch body 10 is hydrocolloid, but the scope of the present invention is not limited thereto.

This patch body 10 has an adhesive layer 12 formed on one side, and when the needle base 30 is placed on the patch body 10, the area of the patch body 10 where the needle base 30 is not placed is The adhesive layer 12 is exposed. This part serves to attach the patch body 10 to the body, for example facial skin, when the microneedle patch 1 is used. Therefore, the adhesive layer 12 is covered and protected by the protective release sheet 50 before use.

The plurality of microneedles 20 are loaded with an effective substance and exhibit their function. In this embodiment, the plurality of microneedles 20 are provided with different heights in order to uniform the penetration depth into the skin. This will be described in detail later.

And the needle base 30 supports the arrangement of the plurality of microneedles 20.

In this embodiment, the needle base 30 and the plurality of microneedles 20 may be provided as one body. More specifically, the DNA solution is injected into the microneedle mold to cure the DNA and then separated from the microneedle mold. In this way, the needle base 30 and the plurality of microneedles 20 can be provided integrally.

In this embodiment, fine-sized DNA microneedles 20 are formed using three-dimensional nanopatterning technology.

3D nanopatterning technology refers to a technology that absorbs effective substances without pain by forming fine-sized DNA microneedles (20) and attaching them to the skin. This is a patch made primarily of DNA material rather than hyaluronic acid or polyvinylpyrrolidone, which are common microneedle patches, and is loaded with bioactive substances to perform its function. In particular, DNA is a substance that is already used as a treatment for skin regeneration, and its safety is guaranteed. In addition, the length or height of the microneedles (20) for cosmetics and pharmaceuticals can be adjusted to suit the intended use, allowing the drug to be transported and penetrated into the appropriate skin layer.

The plurality of microneedles 20 according to this embodiment manufactured in this way are dissolved in the body and are usually dissolved within 10 minutes.

And the average height of the microneedles 20 may be appropriately selected to reach the epidermal layer or dermal layer below the stratum corneum. For example, human skin may include from the epidermis to the stratum corneum (<20 μm), the epidermal layer (<100 μm), and the dermal layer (300 μm to 2,500 μm). Therefore, in order to deliver a viscous composition containing a skin care ingredient or drug to a specific skin layer without pain, the average diameter of the distal end of the microneedle 20 may be within 30㎛, and the average height of the microneedle 20 may be within 30㎛ of the skin. It can have a height between 50㎛ and 500㎛ to reach the epidermis layer or dermis below the stratum corneum.

Meanwhile, in this embodiment, the plurality of microneedles 20 are provided with different heights based on any one of the outline of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. In this embodiment, as can be seen in FIG. 1, the plurality of microneedles 20 are provided so that their height increases from the central area to the outside. This is a case where the penetration depth of the plurality of microneedles 20 can be made uniform by arranging the height of the microneedles 20 in this way. Therefore, the arrangement of the height change of the microneedles 20 can be derived in various ways depending on the conditions.

And in this embodiment, at least one microneedle 20 among the microneedles 20 with the maximum height and the microneedles 20 with the minimum height among the plurality of microneedles 20 is the average of all microneedles 20. It has a difference of more than 20% from the normal height.

Additionally, the plurality of microneedles 20 may have a sharp cone shape or a sharp polygonal cone shape, but in this embodiment, they have a cone shape.

Meanwhile, the first film 40 is disposed between the patch body 10 and the needle base 30. As a result, the patch body 10 is coupled to one side and the needle base 30 is coupled to the other side, and the primary film 40 serves to couple the needle base 30 to the patch body 10. However, the scope of the present invention is not limited to this, and the needle base 30 may be directly attached to the patch body 10 without using the primary film 40.

However, this primary film 40 may be a needle adhesive doubler film that doubles the adhesion of the needle base 30 to the patch body 10. As described above, the needle base 30 may be directly attached to the patch body 10, but in this case, the adhesive strength may be insufficient. To compensate for this, the first film 40 can be applied as a needle adhesive doubler film that doubles the adhesive force. However, the scope of the present invention is not limited to this, and the primary film 40 may be applied as a film that performs this function in order to prevent wrinkles from occurring when the needle base 30 is adhered to the patch body 10. It might be possible.

On the other hand, the protective release sheet 50 is provided with a through hole 52 in the area corresponding to the needle base 30 when disposed for attachment to the patch main body 10, and can cover the patch main body 10. It is provided in a size so that at least a portion of the area is attached to the adhesive layer 12 to protect the adhesive layer 12. When storing the microneedle patch (1) with this configuration, the adhesive layer (12) is protected by the protective release sheet (50), and when using the microneedle patch (1), the protective release sheet (50) is removed to expose the exposed adhesive layer. The microneedle patch 1 can be attached to the skin using the layer 12.

Figure 3 is a perspective view schematically showing main parts of the microneedle patch according to the second embodiment of the present invention. As shown, in this embodiment, the microneedle patch 1a has a plurality of microneedles 20a. It is arranged so that the height increases from one side to the other. This is based on any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. When the plurality of microneedles 20a are arranged so that the height increases from one side to the other side, the plurality of microneedles (20a) Applies when the penetration depth of 20a) can be made uniform.

4(a) to 4(c) are diagrams showing modified examples of microneedle height as modified examples of the first and second embodiments of the present invention, where the arrow length is the height of the microneedle 20. shows. As shown here, in order to uniformize the penetration depth of the plurality of microneedles 20, the microneedles 20 are selected from the outline of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. Based on this, the height arrangement can be arranged in various ways.

Here, FIG. 4(a) shows that, contrary to the first embodiment of the present invention, the plurality of microneedles 20, 20a are provided so that the height decreases from the central area to the outskirts. ) is a case in which the penetration depth of the plurality of microneedles 20 and 20a can be made uniform, and in Figure 4(b), the pattern of Figure 4(a) is provided to be repeated. In this case, in Figure 4(c), the penetration depth of the plurality of microneedles 20 and 20a is provided to periodically repeat a pattern in which the plurality of microneedles 20 decrease in height from one side to the other side. This is a case where it can be made uniform.

Meanwhile, Figure 5 is a perspective view schematically showing main parts of the microneedle patch according to the third embodiment of the present invention. As shown, the microneedle patch 1b according to the third embodiment of the present invention is a patch. A needle base (30b) provided with a main body (10b) and a plurality of unit needle bases (30b) spaced apart from each other, a plurality of microneedles (20b), and a plurality of needle bases (30b) corresponding to the plurality of unit needle bases (30b). It includes a unit primary film 40b and a protective release sheet (not shown).

Compared to the first and second embodiments of the present invention, the microneedle patch (1b) according to the third embodiment of the present invention is somewhat different in the form in which the height of the microneedles (20b) is arranged. What is different is that the needle base 30b is provided as a plurality of unit needle bases 30b spaced apart from each other. By this configuration, when a plurality of unit needle bases (30b) are disposed on the patch body (10b), the area of the patch body (10) between the unit needle bases (30b) where the unit needle bases (30b) are not disposed is adhesive. The layer 12b is exposed to form an adhesion improvement portion 12b that strengthens adhesion to the skin.

That is, in this embodiment, the area of the patch body (10b) other than the needle base (30b) where the microneedles are arranged is the adhesive layer (12b), which is the adhesion improvement portion (12b), so the microneedle patch (1b) according to this embodiment is applied to the skin. When attached, the microneedles 20b can be inserted and maintained in the skin without falling much more than before. Due to this improvement in adhesion, even the large-area microneedle patch (1b) can be maintained on the skin without lifting, making it possible to manufacture the large-area microneedle patch (1b), which was difficult to manufacture in the past.

Meanwhile, the unit needle base 30b may have a predetermined area and at least one of a circular shape and a polygonal shape. In this embodiment, the unit needle base 30b has a circular shape. However, the scope of the present invention is not limited to this, and may have various shapes such as triangles, squares, pentagons, octagons, and ovals.

In this embodiment, the height of the plurality of microneedles 20b disposed in one unit needle base 30b is substantially the same, but in order to uniform the penetration depth of the plurality of microneedles 20, Depending on the contour, curvature of the body surface, and the thickness of the skin for each body part, the height of the micro needle 20b is different for each unit needle base 30b.

That is, as can be seen in FIG. 5, the height of the plurality of microneedles 20b disposed within the unit needle base 30b indicated by A is substantially the same, and the height of the plurality of microneedles 20b disposed within the unit needle base 30b indicated by B is substantially the same. The height of the microneedles 20b is substantially the same, and the height of the plurality of microneedles 20 disposed in the unit needle base 30b indicated by C is also substantially the same, but the unit needle base indicated by A is ( 30b), the height of the plurality of microneedles (20b) disposed in the unit needle base (30b) indicated by B, and the unit needle base (30b) indicated by C. The heights of the plurality of microneedles 20b disposed within are different when compared to each other.

As mentioned above, in the conventional case, there was a problem in that it was relatively difficult to penetrate the micro needle 20b into areas where the skin was thick or dented. However, according to the present embodiment, the unit needle base 30b corresponding to the area where the skin was thick or depressions was relatively difficult. ) It is possible to solve this problem by providing a high height of the plurality of microneedles (20b), that is, by providing a long length of the microneedles (20b).

In addition, since the unit needle base (30b) can be easily placed at the position of the patch body (10b) by the method of attaching the unit needle base (30b) to the patch body (10b), the outline of the body surface and the body surface It has the effect of being able to respond flexibly and adaptively according to the curvature and thickness of the skin of each body part.

Meanwhile, in this embodiment as well, the unit primary film (40b) is disposed between the patch body (10b) and the unit needle base (30b). As a result, the patch body (10b) is coupled to one side and the unit needle base (30b) is coupled to the other side, and the unit primary film (40b) serves to couple the unit needle base (30b) to the patch body (10b). . However, the scope of the present invention is not limited to this, and the unit needle base (30b) may be directly attached to the patch body (10b) without using the unit primary film (40b).

However, this unit primary film (40b) may be a unit needle adhesive doubler film that doubles the adhesion of the unit needle base (30b) to the patch body (10b). As described above, the unit needle base (30b) may be directly attached to the patch body (10b), but in this case, the adhesive strength may be insufficient. To compensate for this, the unit primary film 40b can be applied as a unit needle adhesive doubler film that doubles the adhesive force. However, the scope of the present invention is not limited to this, and the unit primary film (40b) is a film that performs this function to prevent the phenomenon of wrinkles occurring when the unit needle base (30b) is adhered to the patch body (10b). It may also be applied.

The protective release sheet (not shown) is provided with through holes (not shown) in the area corresponding to the unit needle base (30b) when disposed for attachment to the patch body (10b), and covers the patch body (10b). It is provided in a size that can be used to protect the adhesive layer 12b, which is the adhesion improvement portion 12b, so that at least a portion of the area is attached to the adhesion improvement portion 12b. When storing the microneedle patch (1b) with this configuration, it is protected by this protective release sheet, and when using the microneedle patch (1b), the protective release sheet is removed and the adhesive layer (12b), which is the adhesion improvement portion (12b), is exposed. The microneedle patch (1b) can be attached to the skin using .

Below, the operation of the microneedle patch according to this embodiment will be described.

First, when using, remove the protective release sheet 50 to expose the adhesive layer 12 or the adhesion improvement part 12b, and then apply a plurality of microneedle patches (1, 1a, 1b) in contact with the skin surface. Press the microneedles (20, 20a, 20b) so that the tips of the microneedles (20, 20a, 20b) are inserted into the skin. At this time, the microneedle patches (1, 1a, 1b) can be maintained on the skin by the adhesive layers (12, 12a, 12b).

Over time, the solid active substance melts due to skin temperature and/or moisture, and the dissolved active substance diffuses into the skin, that is, toward the dermis. As a result, it can penetrate deeper into the skin more quickly.

According to the microneedle patchmicroneedle patch (1, 1a, 1b) according to this embodiment, a plurality of microneedles are provided based on any one of the outline of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. By providing the heights of the microneedles (20, 20a, 20b) at different heights, the skin penetration depth of the microneedles (20, 20a, 20b) can be ensured evenly and uniformly.

In addition, by forming the adhesion improvement portion 12b between the microneedles 20b, it is easier to adhere to the skin than before without loosening, and in particular, even if the area is large, it can be adhered to the skin more closely than before without being loose.

In addition, the height of the plurality of microneedles 20b disposed within one unit needle base 30b is substantially the same, but in order to uniform the penetration depth of the plurality of microneedles 20b, the contour of the body surface, the body The height of the micro needles 20b is provided differently for each unit needle base 30b depending on the curvature of the surface and the thickness of the skin for each body part, so it is relatively difficult for the micro needles 20b to penetrate areas where the skin is thick or dented. can be solved.

In the above-described third embodiment, the height of the plurality of microneedles 20b disposed within one unit needle base 30b has been described in detail as being substantially the same. However, if necessary, the plurality of microneedles 20b disposed within one unit needle base 30b have been described in detail. The height of the microneedles 20b may also be provided differently.

Although this embodiment has been described in detail with reference to the drawings, the scope of this embodiment is not limited to the drawings and description.

As such, the present invention is not limited to the described embodiments, and it is obvious to those skilled in the art that various modifications and changes can be made without departing from the spirit and scope of the present invention. Accordingly, such modifications or variations should be considered to fall within the scope of the claims of the present invention.

1: Microneedle patch 10: Patch body
12, 12a: Adhesion layer 12b: Adhesion improvement part
20, 20a, 20b: Micro needle 30: Needle base
30a: Unit needle base 40: Primary film
40a: Unit primary film 50: Protective release sheet
52: Through hole

Claims (12)

Patch body; and
It includes a plurality of microneedles disposed on the patch body,
In order to uniform the penetration depth of the plurality of microneedles, the plurality of microneedles are provided at different heights based on any one of the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part. Micro needle patch. According to paragraph 1,
Further comprising at least one needle base supporting the arrangement of the plurality of microneedles,
A microneedle patch, wherein the needle base and the plurality of microneedles are integrally prepared by injecting a DNA solution into the microneedle mold, curing the DNA, and then separating it from the microneedle mold. According to paragraph 2,
A microneedle patch disposed between the patch body and the needle base, further comprising a primary film to which the patch body is coupled to one side and the needle base to the other side. According to paragraph 3,
A microneedle patch, characterized in that the first film is a needle adhesive doubling film that doubles the adhesion of the needle base to the patch body. According to paragraph 2,
When the needle base is placed on the patch body, an adhesive layer is exposed in the area of the patch body where the needle base is not placed,
When placed for attachment to the patch body, a through hole is provided in the area corresponding to the needle base, and is provided in a size to cover the patch body, so that at least a portion of the area is attached to the adhesive layer to protect the adhesive layer. A microneedle patch further comprising a release sheet. According to paragraph 1,
Among the plurality of microneedles, at least one microneedle of the maximum height microneedles and the minimum height microneedles has a difference of more than 20% from the average height of all microneedles,
A microneedle patch, wherein the plurality of microneedles are arranged to increase in height from the central area to the outside or from one side to the other. According to paragraph 2,
The needle base is provided with a plurality of unit needle bases spaced apart from each other, and when the plurality of unit needle bases are arranged, an adhesive layer is formed in the area of the patch body between the unit needle bases where the unit needle base is not arranged. A microneedle patch that is exposed and forms an adhesion improvement portion that strengthens adhesion to the skin. In clause 7,
The height of the plurality of microneedles disposed within one unit needle base is substantially the same, but in order to uniform the penetration depth of the plurality of microneedles, the contour of the body surface, the curvature of the body surface, and the thickness of the skin for each body part are adjusted. A microneedle patch, characterized in that the height of the microneedle is different for each unit needle base. In clause 7,
A microneedle patch, wherein the unit needle base has a predetermined area and has at least one of a circular shape and a polygonal shape. In clause 7,
A microneedle patch further comprising a unit primary film disposed between the patch body and the unit needle base, to which the patch body is coupled to one side and the unit needle base to the other side. According to clause 10,
A microneedle patch, wherein the unit primary film is a unit needle adhesive doubler film that doubles the adhesion of the unit needle base to the patch body. In clause 7,
When disposed for attachment to the patch body, a through hole is provided in an area corresponding to the unit needle base, and is provided in a size that can cover the patch body, so that at least a portion of the area is attached to the adhesion improvement portion to protect the adhesive layer. A microneedle patch further comprising a protective release sheet.

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