CN219022975U

CN219022975U - Microneedle patch

Info

Publication number: CN219022975U
Application number: CN202222694452.7U
Authority: CN
Inventors: 张长禄; 王洪; 丁世仓
Original assignee: Shengmengtang Hainan Biotechnology Co ltd
Current assignee: Shengmengtang Hainan Biotechnology Co ltd
Priority date: 2022-10-13
Filing date: 2022-10-13
Publication date: 2023-05-16
Anticipated expiration: 2032-10-13

Abstract

The utility model discloses a microneedle patch, which comprises a patch substrate, a fixing component and a soluble microneedle, wherein the back surface of the patch substrate is stuck with the fixing component, and the soluble microneedle is fixed on the ventral surface of the patch substrate; the fixing component comprises a pressing sheet, an adjusting belt connected with one end of the pressing sheet and a fixing belt connected with the other end of the pressing sheet, wherein the adjusting belt and the fixing belt encircle the patch substrate to be detachably connected to form a clamping space for fixing the microneedle patch. According to the utility model, the microneedle patch can be fixed at the clamping position through the clamping space formed by the adjusting belt and the fixing belt, so that the microneedle patch can be conveniently attached to the skin, the firmness of the microneedle patch is improved, and meanwhile, the ventilation holes are formed in the patch, so that the ventilation property between the patch and the skin can be improved, and the use effect of a user is better.

Description

Microneedle patch

Technical Field

The application relates to the technical field of medical supplies, in particular to a microneedle patch.

Background

Exogenous insulin is a common drug for the treatment of diabetes, and plays a critical role in particular in type I diabetics who are absolutely deficient in insulin. Insulin itself is a peptide drug which is easily enzymatically degraded in the gastrointestinal tract and liver, which seriously affects the biological activity of insulin, so that it is difficult to administer insulin directly by oral administration. Meanwhile, the molecular weight of insulin is large, and the insulin cannot be directly diffused into the skin like a small-molecule transdermal patch due to barrier effect of the skin. At present, injection administration is the preferred administration mode for delivering insulin, the injection administration is fast in absorption, the insulin can be prevented from being degraded in intestines and stomach, but the mode is easy to cause risks such as pain or skin infection, and inconvenience is brought to patients who need frequent insulin medicine injection or needle sickness for a long time.

The microneedle technology is an effective physical penetration-promoting mode, the length of the microneedle is tens of micrometers to a few millimeters, the microneedle can penetrate through the stratum corneum but does not touch the dermis layer and nerve endings, a plurality of micrometer-level channels are created in the epidermis, the stratum corneum obstacle is overcome in a minimally invasive painless mode, the formed micropore channels can be repaired by themselves, the percutaneous penetration of insulin drug molecules is effectively promoted, and the purposes of subcutaneously reducing blood sugar of a human body and treating diabetes are achieved.

However, when the existing insulin microneedle is stuck on the corresponding part, the phenomena of unstable sticking and easy falling caused by difficult clamping are easy to occur, so that the functional medicine in the microneedle can not be well absorbed, and the administration effect is reduced. The adhesive tape structure is arranged around some microneedle patches, the microneedle patches are adhered to the skin so as to prevent the microneedle patches from falling off, and the adhesive tape has a good fixing effect, but the skin at the adhesive tape adhering part is airtight, and meanwhile, the skin is easily pulled when the microneedle patches are removed, so that the skin is red, swelling and pain, and the like, and the use effect of a user is poor.

Disclosure of Invention

The embodiment of the application provides a microneedle patch for solve among the prior art microneedle patch paste infirm easily drop, airtight technical problem when using.

In view of this, the present application provides a microneedle patch comprising: the patch comprises a patch substrate, a fixing component and a soluble microneedle, wherein the back surface of the patch substrate is adhered to the fixing component, and the soluble microneedle is fixed on the ventral surface of the patch substrate;

the fixing component comprises a pressing sheet, an adjusting belt connected with one end of the pressing sheet and a fixing belt connected with the other end of the pressing sheet, wherein the adjusting belt and the fixing belt encircle the patch substrate and are detachably connected to form a clamping space.

Preferably, the ventral surface of the patch substrate is provided with a protective strip, and a plurality of ventilation holes are uniformly distributed on the protective strip.

Preferably, the patch matrix surface area is greater than the tablet surface area.

Preferably, the soluble microneedles are uniformly distributed on the ventral surface of the patch matrix in an array manner.

Preferably, the soluble microneedles have a height of 400-600 μm.

Preferably, the adjusting belt is provided with a magnetic attraction piece, and the fixing belt is provided with a magnetic piece in magnetic attraction fit with the magnetic attraction piece.

Preferably, the magnetic member is provided in plurality.

Preferably, the plurality of magnetic pieces are embedded in the fixing belt in a strip shape continuously, and the adjusting belt provided with the magnetic pieces can move to the fixing belt provided with the magnetic pieces in the circumferential direction so as to adjust the size of the clamping space.

Preferably, a spherical bulge is arranged on the adjusting belt, and a circular through hole and a notch connected with the circular through hole are arranged on the fixing belt.

Preferably, the circular through holes and the incisions connected with the circular through holes are provided in a plurality, the incisions are arranged on the surface of the fixing belt at intervals in a strip shape, and the adjusting belt provided with the spherical protrusions can circumferentially move to the fixing belt provided with the circular through holes so as to adjust the size of the clamping space.

Compared with the prior art, the utility model has the beneficial effects that:

according to the microneedle patch placement position required by a user, the microneedle patch placement position can be a hand, a leg and the like, and the microneedle patch placement position can be fixed by the aid of a closed clamping space formed by a pressing sheet, an adjusting belt and a fixing belt by means of magnetic attraction or a mode corresponding to a protruding through hole.

A plurality of magnetic pieces are continuously distributed in the fixing belt in a belt shape, and the magnetic pieces on the adjusting belt can be attached to any one of the magnetic pieces on the fixing belt through magnetism to form clamping spaces with different closed sizes, so that the magnetic pieces corresponding to the magnetic pieces are determined according to the size of the required clamping spaces.

The patch matrix back is adhered with the preforming of fixed subassembly, and the preforming has certain hardness and thickness, through the effort between hand and preforming, the perpendicular skin that pierces of soluble microneedle on the promotion patch matrix that can be better avoids skin resilience to lead to the microneedle plaster to be unable to pierce the skin completely and influence the treatment of percutaneous administration.

The microneedle patch is characterized in that a protective strip is arranged on a microneedle patch substrate, air holes are formed in the protective strip, after the microneedle patch is penetrated into the skin, a certain time is needed for the medicine in the soluble microneedle to diffuse into the skin, and the air holes enable the microneedle patch to be attached to the skin in a clinging mode, so that air permeability can be increased.

The soluble micro-needle is prepared from saccharides or polymer materials with good biocompatibility, and insulin macromolecular drugs with the function of reducing blood sugar are wrapped in the soluble micro-needle, so that the soluble micro-needle can be directly dissolved under the skin during administration, and the drugs are released into the living skin layer, so that some sharp medical wastes can be prevented from remaining in the body. The height of the soluble microneedle is 400-600 mu m, so that the soluble microneedle can penetrate dermis and avoid stimulating dermal nerves or puncturing dermal blood vessels. The whole needle body of the soluble micro needle can carry medicine, so that the medicine carrying amount of insulin is improved.

The fixed band surface is banded interval distribution and has a plurality of circular through-holes, and after the microneedle pressed pierces skin, the globular arch on the regulation area can form the closed centre gripping space of equidimension not through pressing to the circular through-hole of difference, withholds corresponding circular through-hole according to the size of centre gripping position, and the microneedle subsides can be fine by fixing this moment, and laminating skin that also can be fine simultaneously is difficult for droing.

The microneedle patch provided by the utility model can be well attached to the skin after penetrating into the skin, and can be well fixed by virtue of the fixing component, so that the microneedle patch is not easy to fall off, the medicine absorption in the soluble microneedle is promoted, the effect of reducing blood sugar is achieved, the air permeability of the skin at the place can be increased when the microneedle patch is used, the skin is not damaged by pulling when the microneedle patch is removed, and the use effect of a user is better.

Drawings

Fig. 1 is a front view of the structure of a microneedle patch provided in an embodiment of the present application;

FIG. 2 is a top view of a construction of a patch substrate provided in an embodiment of the present application;

FIG. 3 is a front view of the structure of a microneedle patch provided in an embodiment of the present application in which a magnetic attraction member cooperates with a magnetic member;

FIG. 4 is a front view of the structure of the microneedle patch provided in the embodiments of the present application, with the spherical protrusions cooperating with the circular through holes, and with the adjustment strap removed from the fixation strap;

FIG. 5 is a front view of the structure of the microneedle patch provided in the embodiments of the present application with spherical protrusions cooperating with circular through holes and with adjustment straps connected to the fixation straps;

wherein, the reference numerals are as follows:

1. a patch substrate; 12. the ventral surface of the patch matrix; 13. the back of the patch matrix; 14. a guard bar; 141. ventilation holes;

2. a soluble microneedle; 21. a needle tip;

3. a fixing assembly; 31. tabletting; 32. an adjusting belt; 33. a fixing belt; 321. a magnetic attraction piece; 322. a spherical protrusion; 331. a magnetic member; 332. a circular through hole; 333. a notch;

4. clamping space.

Detailed Description

In order to make the present application solution better understood by those skilled in the art, the following description will clearly and completely describe the technical solution in the embodiments of the present application with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

Example 1

For ease of understanding, referring to fig. 1 to 2, an embodiment of a microneedle patch provided by the present utility model includes: the patch matrix 1, the fixing component 3 and the soluble micro-needles 2 are stuck, the back surface 13 of the patch matrix is stuck to the fixing component 3, and the soluble micro-needles 2 are fixed on the ventral surface 12 of the patch matrix;

the fixing component 3 comprises a pressing sheet 31, an adjusting belt 32 connected with one end of the pressing sheet 31 and a fixing belt 33 connected with the other end of the pressing sheet 31, wherein the adjusting belt 32 and the fixing belt 33 encircle the patch substrate 1 to be detachably connected to form a clamping space 4 for fixing the microneedle patch.

The working principle of the utility model is as follows: when a user needs to use the microneedle patch, the palm center is placed on the pressing sheet 31 and the soluble microneedle tips 21 on the microneedle patch are vertically aligned with the skin of the part to be pierced, and when the microneedle patch is pressed by the hand applying force, the microneedle patch vertically pierces the skin, the insulin macromolecular drug wrapped in the soluble microneedle 2 is sent to the subcutaneous through the temporary permeation channel, and gradually released and plays a hypoglycemic role as the soluble microneedle 2 dissolves subcutaneously. Meanwhile, after the soluble micro-needles 2 penetrate into the skin, dissolving time is needed, the adjusting belt 32 is circumferentially connected to the direction of the fixing belt 33 to form a closed clamping space 4 so as to fix the micro-needle plaster, so that the micro-needle plaster can be better attached to the skin, and after the micro-needles are absorbed and dissolved, the adjusting belt 32 is released.

It should be noted that, according to the microneedle patch placement position required by the user, the microneedle patch placement position can be a position such as a hand or a leg, and the closed clamping space 4 formed by the pressing sheet 31, the adjusting belt 32 and the fixing belt 33 is used for adjusting the length of the adjusting belt 32 circumferentially around the fixing belt 33 so as to adjust the size of the clamping space, so that the clamping space 4 can accommodate the placement position, the microneedle patch can be better attached to the skin at the position, and meanwhile, the adjusting belt 32 and the fixing belt 33 are connected together to fix the microneedle patch and not easy to fall off.

The patch substrate 1 can be in a circular shape, a rectangular shape, a square shape and the like, the back surface 13 of the patch substrate is adhered to the pressing sheet 31 of the fixing component, meanwhile, the pressing sheet 31 has a certain hardness and thickness, and when the pressing sheet 31 is pressed by a hand, pressure can be applied to the patch substrate 1 and the soluble micro-needles 2 are pushed to penetrate into the skin, so that the soluble micro-needles 2 cannot rebound due to the elasticity of the skin.

The soluble micro-needle 2 is prepared from saccharides or polymer materials with good biocompatibility, and macromolecular insulin drugs wrapped in the soluble micro-needle 2 after penetrating into the skin can be gradually released and act along with the subcutaneous dissolution of the micro-needle.

Example 2

As a further improvement to embodiment 1, referring to fig. 2, the guard bar 12 is disposed on the ventral surface 12 of the patch substrate, and a plurality of ventilation holes 121 are uniformly distributed on the guard bar 12, and the surface area of the patch substrate 1 is larger than the surface area of the pressing sheet 31. The soluble microneedles 2 are uniformly distributed in an array on the ventral surface 12 of the patch matrix. The height of the soluble microneedles is 400-600 μm.

It should be noted that, the shape of the pressing sheet 31 is the same as that of the patch substrate 1, and the surface area of the patch substrate 1 is slightly larger than that of the pressing sheet 31, wherein the protecting strip 14 is arranged on the ventral surface 12 of the patch substrate larger than the surface area of the pressing sheet 31, when the microneedle is stuck into the skin, the pressing sheet 31 is pressed to make the microneedle completely adhere to the skin, and meanwhile, a certain time is required for diffusing the drug in the soluble microneedle 2 into the skin, so that the ventilation holes 141 on the protecting strip 14 can increase ventilation property, and the skin at the place is prevented from being dried due to longer adhering time of the patch.

The tabletting 31 has certain hardness and thickness, and can better push the soluble micro-needles on the patch matrix to vertically penetrate into the skin through the acting force between the hands and the tabletting 31, so that the treatment effect of transdermal drug delivery is prevented from being affected because the micro-needle plaster cannot completely penetrate into the skin due to skin rebound.

Example 3

As a further modification of the embodiment 1, referring to fig. 3, the adjusting belt 32 is provided with a magnetic attraction member 321, and the fixing belt 33 is provided with a plurality of magnetic members 331 magnetically engaged with the magnetic attraction member 321; the magnetic pieces 331 are continuously embedded in the fixing belt 33 in a strip shape, and the adjusting belt 32 provided with the magnetic attraction pieces 321 can circumferentially move to the fixing belt 33 provided with the magnetic pieces 331 so as to adjust the size of the clamping space 4.

It should be noted that, the fixing belt 33 is provided with a plurality of magnetic pieces 331 continuously distributed in a belt shape, after the microneedle is pressed into the skin, the magnetic pieces 321 on the adjusting belt 32 can be attached to any one of the magnetic pieces 331 on the fixing belt 33 by magnetism to form the clamping space 4 with different closed sizes, and then the microneedle can be attached to the corresponding magnetic piece 331 by magnetism according to the size of the required clamping space 4, and the skin can be well fixed and attached without pressing by external force.

Example 4

As an improvement of embodiment 1, referring to fig. 4 to 5, fig. 4 is a state where the adjusting belt and the fixing belt are detached, fig. 5 is a state where the adjusting belt and the fixing belt are connected, a spherical protrusion 322 is provided on the adjusting belt 32, a plurality of circular through holes 332 and notches 333 connected with the circular through holes 332 are provided on the fixing belt 33 at intervals in a strip shape on the surface, wherein the circular through holes 332 penetrate the fixing belt 33, the bottom area of the spherical protrusion 322 is larger than the bottom area of the circular through holes 332, the adjusting belt 32 provided with the spherical protrusion 322 can be moved to the fixing belt 33 provided with the circular through holes 332 in the circumferential direction, and the spherical protrusion 322 is pressed to the circular through holes 332 to adjust the size of the clamping space 4.

After the microneedle is pressed into the skin, the adjusting belt 32 is moved to the fixing belt 33 along the circumferential direction according to the size of the clamping part 4, at this time, the spherical protrusion 322 on the adjusting belt 32 corresponds to one of the circular through holes 332, a pressure is applied to the spherical protrusion 322 by hand, because the circular through holes 332 are connected with the notch 333 and penetrate through the fixing belt 33, the notch 333 is in a closed state on the fixing belt 33 when the pressure is not applied, when the spherical protrusion 322 is pressed by aiming at the circular through holes 332, the notch 333 is opened, the penetrating accommodating volume of the circular through holes 332 and the notch 333 in the fixing belt 33 is larger than the volume of the spherical protrusion 322, at this time, the spherical protrusion 322 penetrates through the through holes in the fixing belt 33, then the notch 333 is automatically closed, at this time, the spherical protrusion 322 is exactly clamped to the fixing belt 33, thereby fixing the connection of the adjusting belt 32 and the fixing belt 33, and the microneedle plaster can be well adhered to the skin, and the microneedle plaster is not easy to fall off.

The above embodiments are merely for illustrating the technical solution of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions.

Claims

1. The microneedle patch is characterized by comprising a patch substrate, a fixing component and a soluble microneedle, wherein the back surface of the patch substrate is stuck with the fixing component, and the soluble microneedle is fixed on the ventral surface of the patch substrate;

2. The microneedle patch of claim 1, wherein the ventral surface of the patch substrate is provided with a protective strip, and a plurality of ventilation holes are uniformly distributed on the protective strip.

3. A microneedle patch according to claim 1, in which the patch matrix surface area is greater than the patch surface area.

4. The microneedle patch of claim 1, wherein the soluble microneedles are uniformly distributed in an array on the ventral surface of the patch matrix.

5. The microneedle patch of claim 4, wherein the height of the soluble microneedles is 400-600 μm.

6. The microneedle patch of claim 1, wherein the adjustment strap is provided with a magnetic element, and the fixing strap is provided with a magnetic element magnetically engaging with the magnetic element.

7. The microneedle patch of claim 6, wherein the magnetic member is provided in plurality.

8. The microneedle patch of claim 7, wherein the plurality of magnetic members are continuously embedded in the fixing band in a strip shape, and the adjusting band provided with the magnetic members is circumferentially movable to the fixing band provided with the magnetic members to adjust the size of the holding space.

9. The microneedle patch of claim 1, wherein the adjusting belt is provided with a spherical protrusion, and the fixing belt is provided with a circular through hole and a notch connected with the circular through hole.

10. The microneedle patch of claim 9, wherein the circular through holes and the incisions connected with the circular through holes are provided in plurality, and are arranged on the surface of the fixing belt at intervals in a strip shape, and the adjusting belt provided with the spherical protrusions can be moved to the fixing belt provided with the circular through holes circumferentially to adjust the size of the clamping space.