WO2019177211A1 - Plasma therapy device for treatment of cervical cancer - Google Patents

Plasma therapy device for treatment of cervical cancer Download PDF

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Publication number
WO2019177211A1
WO2019177211A1 PCT/KR2018/009390 KR2018009390W WO2019177211A1 WO 2019177211 A1 WO2019177211 A1 WO 2019177211A1 KR 2018009390 W KR2018009390 W KR 2018009390W WO 2019177211 A1 WO2019177211 A1 WO 2019177211A1
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Prior art keywords
plasma
device housing
cervical cancer
treatment
guide
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PCT/KR2018/009390
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French (fr)
Korean (ko)
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권병수
최은하
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부산대학교병원
광운대학교 산학협력단
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Publication of WO2019177211A1 publication Critical patent/WO2019177211A1/en

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    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00559—Female reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2277/00—Applications of particle accelerators
    • H05H2277/10—Medical devices

Definitions

  • the present invention relates to a plasma treatment apparatus for treating cervical cancer, and more particularly, to a plasma treatment apparatus for treating cervical cancer precancerous lesions using plasma.
  • Cervical cancer is the fourth most common female cancer in the world. More than half a million cancers were diagnosed worldwide in 2012, of which approximately 50% of patients died from the disease.
  • cervical cancer undergoes a stage of precancerous lesions longer than other cancers, it is a disease that can be cured only by early detection, and it is possible to discriminate abnormalities through simpler tests than diagnostic tests of stomach, lung, colon, and thyroid cancer. Given the fact, early detection and active treatment of cervical precancerous lesions is important.
  • cervical precancerous lesions can cause a sudden increase in incidence in younger ages and severe pregnancy-related complications of conventional resections. Therefore, it is urgent to develop new safe and effective therapies given the low birthrate social situation.
  • Atmospheric pressure plasma is an ionized medium containing active ingredients including electrons and ions, free radicals, reactive molecules and photons, and can be classified as either thermal plasma or non-thermal plasma.
  • non-thermal atmospheric pressure plasmas are emerging as new tools in biomedical applications because they can interact with targeted biomaterials without causing thermal damage to surrounding tissues.
  • Korean Patent Nos. 10-1592081 and 10-1248668 there is no published technique for killing cervical cancer cells using low-temperature atmospheric pressure plasma, and killing of cervical cancer cells using low-temperature atmospheric plasma. The method does not have a publicly available technology, and related technology development is urgently needed.
  • an object of the present invention is to provide a plasma treatment apparatus for treating cervical cancer that can treat precancerous lesions of cervical cancer using plasma.
  • Plasma treatment device for cervical cancer treatment of the present invention for achieving the above object, and a probe-type device housing that can enter the planar neck to treat the cervix;
  • a plasma guide part installed at the distal end of the device housing to guide the plasma generated by the plasma generating part to be concentrated on the cervix side.
  • cervical cancer cells can be killed and treated using plasma energy.
  • the plasma guide portion preferably extends from the edge of the front end of the device housing and includes an outer diameter guide member that surrounds and supports the uterine outer tube.
  • the plasma energy is guided to the uterine cervix to increase the cancer cell eradication effect of the uterine cervix.
  • the plasma guide portion preferably extends to narrow gradually from the rim of the front end of the device housing to include an outer diameter guide member for guiding the plasma energy concentrated in the cervical canal.
  • plasma energy can be concentrated in the endometrial tube, thereby effectively eradicating and treating cancer cells in the endometrial tube.
  • the plasma generating unit may include a low temperature atmospheric dielectric barrier (DBD) plasma.
  • DBD low temperature atmospheric dielectric barrier
  • the plasma treatment apparatus for cervical cancer treatment for achieving the above object, a probe-type device housing which can be entered into the planar to treat cervical cancer; A first plasma generating module installed in the device housing to generate plasma for treating the uterine cervix; And a second plasma generation module installed in the device housing to generate a plasma for treating the endometrial canal.
  • the second plasma generating module is preferably arranged to generate plasma energy to the central portion of the plasma generating surface generated by the first plasma generating module.
  • the plasma cells generated by the second plasma generation module may be used to intensively eradicate cancer cells of the uterine inner diameter.
  • the first plasma generation module may include a low temperature atmospheric dielectric barrier (DBD) plasma.
  • DBD low temperature atmospheric dielectric barrier
  • the second plasma generating module may include a low temperature atmospheric plasma jet capable of intensively generating plasma at a central portion of the tip of the device housing.
  • a relatively large area of the endometrium can be treated using a low temperature atmospheric pressure plasma, and a relatively narrow area of the endometrium can be intensively treated using an atmospheric plasma jet.
  • the apparatus may further include a plasma guide unit installed in the device housing to guide the plasma energy generated by the first and second plasma generating modules to be concentrated to the cervix.
  • the plasma guide part may include an outer diameter guide member which extends from the edge of the tip of the device housing to guide the plasma energy generated by the first plasma generating part to the uterine outer tube.
  • the plasma guide unit may further include an inner diameter guide member connected to a central portion of the front end of the device housing to guide the plasma energy generated by the second plasma generating module to be concentrated into the uterine endoscope.
  • the inner tube guide member is formed so as to protrude in the shape of a nozzle from the center of the front end of the device housing is inserted into the endometrial tube to transmit plasma energy.
  • the low-temperature atmospheric pressure plasma energy is concentrated in the endometrial canal, and the atmospheric pressure plasma jet is guided to the endometrial canal to increase the therapeutic effect.
  • the apparatus may further include an internal structure installed inside the device housing to isolate the first and second plasma generating modules.
  • the first and second plasma generating modules driven independently of each other may be installed in one device housing.
  • the internal structure may include a quartz tube, and a gas supply path may be formed between the quartz tube and the device housing to supply gas to the plasma generator of the first plasma generating module.
  • the plasma treatment apparatus for cervical cancer treatment of the present invention it is possible to effectively treat cervical cancer using plasma energy.
  • the uterine cervix can treat a large area using a large-area plasma generator, and the endometrial canal is provided with a complex treatment device for intensive treatment using a plasma jet. There is an advantage that can be treated at the same time using the treatment device.
  • plasma energy can be concentrated in the uterine cervix and the endometrial tube, thereby improving the therapeutic effect.
  • FIG. 1 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a first embodiment of the present invention.
  • FIG. 2 and 3 are schematic views for explaining and extracting the plasma generating unit shown in FIG.
  • FIG. 4 is a view for explaining a state of treating the endometrial tube using the plasma treatment apparatus shown in FIG.
  • Figure 5 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a second embodiment of the present invention.
  • FIG. 6 is a view for explaining a process of treating an endometrial canal using the plasma treatment apparatus shown in FIG. 5.
  • FIG. 7 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a third embodiment of the present invention.
  • FIG. 8 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a fourth embodiment of the present invention.
  • FIG. 9 is a schematic diagram illustrating a process of treating the cervix using the plasma treatment apparatus for treating cervical cancer shown in FIG. 8.
  • the plasma treatment apparatus 100 for treating cervical cancer according to the first embodiment of the present invention may generate plasma energy to the device housing 110 and the tip of the device housing 110.
  • the device housing 110 is formed of an insulating material and has a tubular shape having a predetermined length.
  • the device housing 110 has a sufficient length to enter the vagina of the uterus for the purpose of treating the cervix, and preferably has a circular tubular structure.
  • a gas supply path 111 may be formed in the device housing 110 to supply gas to the plasma generator 120 installed at the tip of the device housing 110.
  • the gas supply path 111 may be formed between the device housing 110 and the internal structure 113 installed inside the device housing 110.
  • the internal structure 113 may be formed of an insulating material, and may include, for example, a quartz tube.
  • the plasma generation unit 120 may have a structure of a so-called DBD () plasma generation method. That is, as shown in FIGS. 1, 2, and 3, the plasma generating unit 120 is installed at the tip of the device housing 110, and the first electrode 123 is installed on the glass substrate 121. And a dielectric 127 provided on the substrate 121 to insulate the second electrode 125 and the first and second electrodes 123 and 125. A gas supply passage h may be minutely formed in the glass substrate 121 to supply gas toward the electrodes 123 and 125.
  • the first and second electrodes 123 and 125 formed on the substrate 121 may be stacked and formed by a semiconductor manufacturing process, and may be formed in various patterns.
  • the second electrode 125 may be formed in a pattern of a mesh structure, and may be formed on the first electrode 123 between the second electrodes 125 of the mesh structure.
  • the gas supply passage (gas hole) h formed in the substrate 121 may also be formed through a semiconductor manufacturing process.
  • the dielectric 127 is formed to cover the first and second electrodes 123 and 125, and is formed to have a predetermined thickness so as to electrically cut off the outside and discharge the plasma effectively.
  • the secondary electron generation layer 128 and the hydration prevention layer 129 may be sequentially stacked on the outer side of the dielectric 127 to be further formed.
  • the secondary electron generation layer 128 and the anti-hydration layer 129 may be formed by a semiconductor manufacturing process such as the dielectric 127 and the electrodes 123 and 125.
  • the secondary electron generation layer 128 may serve to regenerate more charge from the generated plasma.
  • the secondary electron generation layer 128 may be selectively applied.
  • the plasma generating unit 120 having such a configuration can be formed as a surface discharge structure with a desired area without being restricted by the area, and electrode formation can be made by semiconductor manufacturing technology (potolithography technology) to make a fine electrode structure. Thus, high density plasma can be generated even at low power.
  • the plasma generator 120 of the above configuration supplies gas through the gas supply path 111 while applying an alternating voltage to the first and second electrodes 123 and 125, the first and second electrodes 123 and 125 are disposed between the first and second electrodes 123 and 125. In the plasma is generated.
  • the interval between the first and second electrodes 123 and 125 is approximately 100 to 400 ⁇ m
  • the discharge voltage is set to 1 kV or less
  • the discharge current is set to have a characteristic of 10 mA or less.
  • the plasma guide unit 130 guides the plasma energy generated by the plasma generating unit 120 toward the uterine external cervix (extocervix) 10, which is a target human body to be treated.
  • the plasma guide unit 130 includes an outer tube guide member 131 for guiding the generated plasma connected to the distal end of the device housing 110 to the uterine cervix 10 of the cervix.
  • the outer diameter tube guide member 131 is a coupling portion 131a coupled to the front end of the device housing 110 and an expansion rib 131b extending to the coupling portion 131a to surround the outer diameter tube of the cervix. It is provided.
  • the coupling part 131a has a cylindrical structure and may be coupled to an outer edge of the front end of the device housing 110.
  • the expansion rib 131b is integrally formed with the coupling portion 131a and gradually extends in diameter from the coupling portion 131a.
  • the expansion rib 131b having such a configuration may be effectively guided so that the plasma energy generated by the plasma generator 120 may be concentrated on the uterine cervix 10 by wrapping and collecting the uterine outer tube 10. Therefore, cancer cells of the uterine cervix can be effectively killed and treated.
  • the plasma treatment apparatus 100 ′ has plasma energy as an endocervical cannal 20 as the plasma guide unit 130 ′. It is characterized by having an inner diameter guide member 133 having a structure capable of guiding to be concentrated.
  • the inner diameter guide member 133 has a coupling portion 133a coupled to the front end of the device housing 110 and a connection guide portion 133b extending in a funnel shape from the coupling portion 133a and gradually decreasing in diameter. ) And a nozzle guide portion 133c extending in a tubular shape from the connection guide portion 133b.
  • the coupling portion 133a is coupled to the outer side of the front end of the device housing 110, preferably may be detachably coupled.
  • the connection guide portion 133b is integrally extended at a predetermined distance, and the diameter is gradually reduced to extend in a funnel shape.
  • the nozzle guide part 133c extends in the tubular shape of the same diameter at the edge part of the connection guide part 133b. The nozzle guide portion 133c having such a configuration is inserted into the endometrial canal so that plasma energy is concentrated in the uterine canal 20, thereby effectively killing and treating cancer cells on the endometrial canal 20 side.
  • the outer diameter guide member 131 and the inner diameter guide member 133 described above may be integrally formed at the front end of the device housing 110, it may have a structure that can be replaced by a screw fastening method. Therefore, the outer diameter guide member 131 and the inner diameter guide member 133 may be selectively employed according to the treatment area.
  • the plasma treatment apparatus 200 for cervical treatment may be installed in the device housing 201 and the device housing 201 to treat the uterine cervix.
  • a plasma generating module 210 and a second plasma generating module 220 for treating the endometrial canal are provided.
  • the first plasma generating module 210 is installed to generate a plasma in a constant region of the front end of the device housing 201 and the gas supply path 211 for supplying gas toward the front end of the device housing 201
  • the first plasma generating unit 213 is provided.
  • the cylindrical durable structure 215 extends to the first plasma generating unit 213 inside the device housing 201.
  • the internal structure 215 may include a quartz tube and may further include an insulation pipe formed of an insulating material. An electrode or an electric wire cable capable of supplying power to the first plasma generator 213 through the inside of the insulation pipe may be installed.
  • the gas supply path 211 is provided through which gas is supplied between the internal structure 215 and the device housing 201.
  • the first plasma generating unit 213 is installed at the front end of the device housing 201, and is installed to generate plasma at the outer portion except the center portion.
  • the first plasma generator 213 may have the same configuration as that of the plasma generator 120 described above with reference to FIGS. 2 and 3. However, since the second plasma generating module 220 is installed at the central portion of the front end of the device housing 201, the first plasma generating unit 213 is disposed around the center of the second plasma generating module 220. Is installed.
  • the plasma generated by the first plasma generator 213 is used to treat the uterine cervix 10.
  • the second plasma generation module 220 is installed inside the internal structure 215, and preferably, a so-called plasma jet for discharging the atmospheric plasma in a jet manner.
  • a plasma jet can generate atmospheric pressure intensively in a specific portion, and thus, by focusing and discharging the plasma toward the endometrial canal 20, it can be effective in killing cancer cells of the endometrial canal 20.
  • the second plasma generation module 220 may have a configuration of a known plasma jet, and is installed at a central portion of the first plasma generation module 210 to maintain an insulation state with the first plasma generation module 210.
  • the illustrated second plasma generation module 220 may have a configuration in which an external ground electrode 222 and an internal electrode 223 are installed with a quartz tube 221 interposed therebetween.
  • plasma is generated by a gap with the external ground electrode 222 at your portion 223a at the other end of the internal electrode 223.
  • This configuration is formed in a thin tubular shape, and is installed inside the internal structure 215 inside the device housing 201. Therefore, the plasma jet generated at the tip of the second plasma generating module 220 may be concentrated at the center of the tip of the device housing 201 to be concentrated at the inlet side of the endometrial tube 20.
  • the plasma generated by the first plasma generator 210 is concentrated on the uterine cervix 20, and used to kill cancer cells of the ectopic tube 10.
  • a so-called hybrid plasma treatment apparatus in which DBD (Dielectric Barrier Discharge) plasma and plasma jet are mixed is used.
  • DBD Dielectric Barrier Discharge
  • a device installed in the device housing 201 and the device housing 201 is provided.
  • First and second plasma generation module 210, 220 and the plasma guide unit 230 is provided.
  • first and second plasma generation module 210, 220 has been described in detail with reference to Figures 7 and 8, further description thereof will be omitted.
  • the plasma guide unit 230 includes an outer diameter guide member 231 and an inner diameter guide member 233.
  • the outer diameter guide member 231 serves to guide the plasma energy generated by the first plasma generating module 210 toward the uterine outer tube 10.
  • the outer diameter guide member 213 may have the same configuration as the outer diameter guide member 131 described above with reference to FIG. 1. That is, the outer tube guide member 231 is connected to the outer edge of the front end of the device housing 201, and extends outward to support the outer uterine tube 10 so as to concentrate the plasma on the uterine tube 10. Play a role.
  • the inner diameter guide member 233 is installed at a boundary between the first plasma generating module 210 and the second plasma generating module 220 and has a nozzle shape having a predetermined diameter.
  • the inner diameter guide member 233 has a diameter enough to enter the inner diameter tube so that the plasma jet is concentrated to the inside of the uterine inner tube 20, it is preferably formed to a predetermined length.
  • the inner diameter guide member 233 may be formed of a dielectric, and may be integrally formed by being connected to the dielectric of the first plasma generating module 210.
  • the plasma generated by each of the endometrial tube 10 and the endometrial tube 20 acts on each site. It can effectively treat precancerous lesions.
  • the inner tube guide member 233 passes through the endometrial tube 20 and enters the uterus to directly reach the inner precancerous lesion so that the cancer cells can be effectively killed and treated.

Abstract

Disclosed is a plasma therapy device for treatment of cervical cancer, comprising: a probe-shaped device housing which can be inserted into a vaginal speculum in order to treat the cervix; a plasma generation unit for generating plasma energy and emitting the generated plasma to an end of the device housing; and a plasma guiding unit installed at the end of the device housing to guide plasma, generated by the plasma generation unit, toward the cervix so as to focus the plasma on the cervix.

Description

자궁경부암 치료용 플라즈마 치료장치Plasma treatment device for cervical cancer treatment
본 발명은 자궁경부암 치료용 플라즈마 치료장치에 관한 것으로서, 보다 상세하게는 자궁경부암 전암병변을 플라즈마를 이용하여 치료하기 위한 플라즈마 치료장치에 관한 것이다.The present invention relates to a plasma treatment apparatus for treating cervical cancer, and more particularly, to a plasma treatment apparatus for treating cervical cancer precancerous lesions using plasma.
자궁경부암은 세계적으로 4번째로 흔한 여성 암이다. 2012년 전 세계적으로 50만 건 이상의 암이 진단되었고, 그중 대략 50%의 환자가 이 질병으로 사망한 것으로 나타났다.Cervical cancer is the fourth most common female cancer in the world. More than half a million cancers were diagnosed worldwide in 2012, of which approximately 50% of patients died from the disease.
미국에서는 매년 약 13,000건의 침윤성 자궁경부암과 약 4,100건의 암 관련 사망이 발생하고 있는 것으로 나타났다.In the United States, about 13,000 invasive cervical cancers and about 4,100 cancer-related deaths occur each year.
이러한 자궁경부암은 다른 암에 비하여 오랜 기간 전암병변의 단계를 거치기 때문에 조기발견만 하면 완치가 가능한 질환이고, 위, 폐, 대장, 갑상선암의 진단적 검사보다도 간단한 검사를 통해 이상 유무를 감별해낼 수 있다는 사실을 감안한다면, 자궁경부 전암병변을 조기발견하고 적극적인 치료가 중요하다.Since cervical cancer undergoes a stage of precancerous lesions longer than other cancers, it is a disease that can be cured only by early detection, and it is possible to discriminate abnormalities through simpler tests than diagnostic tests of stomach, lung, colon, and thyroid cancer. Given the fact, early detection and active treatment of cervical precancerous lesions is important.
국내는, 자궁경부암은 지속적으로 감소하는 반면, 자궁경부 전암병변 발명자는 전반적으로 증가하는 추세이며, 의료 이용 빈도가 급속하게 증가하고 있다.In Korea, while cervical cancer continues to decrease, the number of inventors of cervical precancerous lesions is generally increasing, and the frequency of medical use is rapidly increasing.
현재 이러한 자궁경부 전암병변에 대한 치료약물은 없으며, 유일한 치료법으로는 수술적 절제술뿐이며, 수술 절제 방법으로는 루프 환상투열 절제술(Loop electrosurgical excision procedure; LEEP), 자궁경부 원추형 생검술(cervical coniztion), 레이저 생검술(laser excision) 및 자궁절제술(hysterectomy)이 있다.Currently, there are no drugs for treating cervical precancerous lesions, the only treatment is surgical resection, and surgical resection methods include loop electrosurgical excision procedure (LEEP), cervical coniztion, Laser excision and hysterectomy.
그런데 이러한 수술요법은 조산, 유산, 불임 및 이로 인한 출산율 감소의 사회문제를 야기하고 있으며, 불완전 수술의 경우 재발 위험이 있는 문제점이 있다. 또한, 확률은 높지 않지만 조산에 의한 뇌성마비, 망막장애, 폐성숙저하 출산의 위험이 있다.By the way, such surgical therapy causes a social problem of premature birth, miscarriage, infertility and reduced fertility rate, and there is a problem that there is a risk of relapse in incomplete surgery. In addition, although the probability is not high, there is a risk of premature birth, cerebral palsy, retinal disorder, and low prematurity.
이와 같이, 자궁경부 전암병변이 젊은 연령에서 발생률 급증과 기존 원추절제술의 임신관련 심각한 합병을 야기할 수 있어 현재 저출산의 사회 상황을 고려했을 때 안전하고 효과적인 새로운 치료법의 개발이 시급하다.As such, cervical precancerous lesions can cause a sudden increase in incidence in younger ages and severe pregnancy-related complications of conventional resections. Therefore, it is urgent to develop new safe and effective therapies given the low birthrate social situation.
한편, 최근에는 암세포의 치료를 위한 방법 중에, 시술적 치료 방법 이외에 다양한 치료방법이 활발하게 연구개발되고 있는데, 이 중에서 통증을 야기하지 않으면서도 암세포를 사멸할 수 있는 플라즈마 치료기기의 개발이 활발히 이루어지고 있다.On the other hand, in recent years, among the methods for the treatment of cancer cells, various treatment methods in addition to the surgical treatment method has been actively researched and developed, among which the development of a plasma treatment device that can kill cancer cells without causing pain is actively made have.
대기압 플라즈마는 전자 및 이온, 자유 라디칼, 반응성 분자 및 광자를 포함하는 활성성분을 함유하는 이온화된 배지이며, 열적 플라즈마(thermal plasma) 또는 저온 플라즈마(non-thermal plasma)로 분류할 수 있다.Atmospheric pressure plasma is an ionized medium containing active ingredients including electrons and ions, free radicals, reactive molecules and photons, and can be classified as either thermal plasma or non-thermal plasma.
특히, 저온 대기압 플라즈마(non-thermal atmospheric pressure plasma)는 주변 조직에 열 손상을 일으키지 않으면서 타깃이 된 생체 물질과 상호 작용할 수 있기 때문에 생체 의약 응용 분야에서 새로운 도구로 부상하고 있다. 그러나 한국 등록특허 제10-1592081호 및 제10-1248668호에 나타난 바와 같이, 저온 상압 플라즈마를 이용한 자궁경부 암세포의 사멸방법은 공개된 기술이 없으며, 이와 같은 저온 대기압 플라즈마를 이용한 자궁경부 암세포의 사멸방법은 공개된 기술이 없으며, 이와 관련된 기술개발이 시급한 실정이다.In particular, non-thermal atmospheric pressure plasmas are emerging as new tools in biomedical applications because they can interact with targeted biomaterials without causing thermal damage to surrounding tissues. However, as shown in Korean Patent Nos. 10-1592081 and 10-1248668, there is no published technique for killing cervical cancer cells using low-temperature atmospheric pressure plasma, and killing of cervical cancer cells using low-temperature atmospheric plasma. The method does not have a publicly available technology, and related technology development is urgently needed.
본 발명은 상기와 같은 문제점을 해결하기 위하여 창안된 것으로서, 플라즈마를 이용하여 자궁경부암의 전암병변을 치료할 수 있는 자궁경부암 치료용 플라즈마 치료장치를 제공하는데 그 목적이 있다.The present invention has been made to solve the above problems, an object of the present invention is to provide a plasma treatment apparatus for treating cervical cancer that can treat precancerous lesions of cervical cancer using plasma.
상기 목적을 달성하기 위한 본 발명의 자궁경부암 치료용 플라즈마 치료장치는, 자궁경부를 치료하기 위해 질경 내에 진입될 수 있는 프로브 형의 장치 하우징과; 상기 장치 하우징의 선단으로 플라즈마 에너지를 발생시키는 플라즈마 발생부; 및 상기 장치 하우징의 선단부에 설치되어 상기 플라즈마 발생부에서 생성된 플라즈마를 자궁경부 쪽에 집중되도록 가이드 하는 플라즈마 가이드부;를 포함하는 것을 특징으로 한다.Plasma treatment device for cervical cancer treatment of the present invention for achieving the above object, and a probe-type device housing that can enter the planar neck to treat the cervix; A plasma generator for generating plasma energy at a tip of the device housing; And a plasma guide part installed at the distal end of the device housing to guide the plasma generated by the plasma generating part to be concentrated on the cervix side.
이로써, 플라즈마 에너지를 이용하여 자궁경부 암세포를 사멸하여 치료할 수 있다.Thus, cervical cancer cells can be killed and treated using plasma energy.
여기서, 상기 플라즈마 가이드부는, 상기 장치 하우징의 선단의 테두리로부터 확장되어 연장되어 자궁외경관을 감싸서 지지하는 외경관 가이드부재를 포함하는 것이 바람직하다.Here, the plasma guide portion preferably extends from the edge of the front end of the device housing and includes an outer diameter guide member that surrounds and supports the uterine outer tube.
또한, 상기 외경관 가이드부재는, 상기 장치 하우징의 선단에 결합되는 결합부; 및 상기 결합부에서 확장 형성되어 자궁외경관을 감싸도록 형성되는 확장리브;를 포함하는 것이 좋다.In addition, the outer diameter pipe guide member, the coupling portion coupled to the front end of the device housing; And expansion ribs formed to expand in the coupling part and surround the uterine cervix.
이로써, 자궁외경관으로 플라즈마 에너지가 집중되게 가이드 하여 자궁외경관의 암세포 박멸효과를 높일 수 있다.As a result, the plasma energy is guided to the uterine cervix to increase the cancer cell eradication effect of the uterine cervix.
또한, 상기 플라즈마 가이드부는, 상기 장치 하우징의 선단의 테두리로부터 점진적으로 좁아지도록 연장되어 자궁내경관으로 플라즈마 에너지가 집중되도록 가이드 하는 외경관 가이드부재를 포함하는 것이 좋다.In addition, the plasma guide portion, preferably extends to narrow gradually from the rim of the front end of the device housing to include an outer diameter guide member for guiding the plasma energy concentrated in the cervical canal.
이로써, 자궁내경관으로 플라즈마 에너지를 집중시켜서 자궁내경관의 암세포를 효과적으로 박멸하여 치료할 수 있다.As a result, plasma energy can be concentrated in the endometrial tube, thereby effectively eradicating and treating cancer cells in the endometrial tube.
또한, 상기 플라즈마 발생부는 저온대기압 유전체장벽(DBD;Dielectric Barrier Discharge) 플라즈마를 포함하는 것이 좋다.In addition, the plasma generating unit may include a low temperature atmospheric dielectric barrier (DBD) plasma.
또한, 상기 목적을 달성하기 위한 본 발명의 다른 측면에 따른 자궁경부암 치료용 플라즈마 치료장치는, 자궁경부암을 치료하기 위해 질경 내에 진입될 수 있는 프로브 형의 장치 하우징; 상기 장치 하우징에 설치되어 자궁외경관을 치료하기 위한 플라즈마를 발생시키는 제1플라즈마 발생모듈; 및 상기 장치 하우징에 설치되어 자궁내경관을 치료하기 위한 플라즈마를 발생시키는 제2플라즈마 발생모듈;을 포함하는 것을 특징으로 한다.In addition, the plasma treatment apparatus for cervical cancer treatment according to another aspect of the present invention for achieving the above object, a probe-type device housing which can be entered into the planar to treat cervical cancer; A first plasma generating module installed in the device housing to generate plasma for treating the uterine cervix; And a second plasma generation module installed in the device housing to generate a plasma for treating the endometrial canal.
이로써, 자궁외경관과 자궁내경관 각각으로 서로 다른 종류의 플라즈마 에너지를 집중하여 자궁경부 암세포를 효과저적으로 박멸하여 치료할 수 있다.Thus, different types of plasma energy can be concentrated into the uterine cervix and the endometrial tube to effectively eradicate cervical cancer cells and to treat them.
여기서, 상기 제2플라즈마 발생모듈은 상기 제1플라즈마 발생모듈에서 발생시키는 플라즈마 발생면의 중앙부분으로 플라즈마 에너지를 발생하도록 배치되는 것이 바람직하다.Here, the second plasma generating module is preferably arranged to generate plasma energy to the central portion of the plasma generating surface generated by the first plasma generating module.
이로써, 제2플라즈마 발생모듈에서 발생되는 플라즈마 에너지를 이용하여 자궁내경의 암세포를 집중적으로 박멸할 수 있다.As a result, the plasma cells generated by the second plasma generation module may be used to intensively eradicate cancer cells of the uterine inner diameter.
또한, 상기 제1플라즈마 발생모듈은, 저온대기압 유전체장벽(DBD;Dielectric Barrier Discharge) 플라즈마를 포함하는 것이 좋다.In addition, the first plasma generation module may include a low temperature atmospheric dielectric barrier (DBD) plasma.
또한, 상기 제2플라즈마 발생모듈은, 상기 장치 하우징의 선단부의 중심부에서 플라즈마를 집중적으로 발생시킬 수 있는 저온 대기압 플라즈마 제트를 포함하는 것이 좋다.The second plasma generating module may include a low temperature atmospheric plasma jet capable of intensively generating plasma at a central portion of the tip of the device housing.
이로써, 상대적으로 넓은 면적의 자궁외경관은 저온대기압 플라즈마를 이용하여 치료하고, 상대적으로 좁은 면적의 자궁내경막은 대기압 플라즈마 제트를 이용하여 집중적으로 치료할 수 있게 된다.As a result, a relatively large area of the endometrium can be treated using a low temperature atmospheric pressure plasma, and a relatively narrow area of the endometrium can be intensively treated using an atmospheric plasma jet.
또한, 상기 장치 하우징에 설치되어 상기 제1 및 제2플라즈마 발생모듈에서 생성되는 플라즈마 에너지가 자궁경부로 집중되도록 가이드 하는 플라즈마 가이드부를 더 포함하는 것이 좋다.The apparatus may further include a plasma guide unit installed in the device housing to guide the plasma energy generated by the first and second plasma generating modules to be concentrated to the cervix.
또한, 상기 플라즈마 가이드부는, 상기 장치 하우징의 선단의 테두리에서 연장되어 자궁외경관으로 상기 제1플라즈마 발생부에서 생성된 플라즈마 에너지가 집중되도록 가이드 하는 외경관 가이드부재를 포함하는 것이 좋다.The plasma guide part may include an outer diameter guide member which extends from the edge of the tip of the device housing to guide the plasma energy generated by the first plasma generating part to the uterine outer tube.
또한, 상기 플라즈마 가이드부는, 상기 장치 하우징의 선단부 중앙부분에 연결되어 상기 제2플라즈마 발생모듈에서 생성된 플라즈마 에너지가 자궁내경관으로 집중되도록 가이드하는 내경관 가이드부재를 더 포함하는 것이 좋다.The plasma guide unit may further include an inner diameter guide member connected to a central portion of the front end of the device housing to guide the plasma energy generated by the second plasma generating module to be concentrated into the uterine endoscope.
또한, 상기 내경관 가이드부재는, 상기 장치 하우징의 선단 중앙에서 노즐형상으로 돌출 연장되어 상기 자궁내경관 내부로 삽입되어 플라즈마 에너지를 전달할 수 있도록 형성된 것이 좋다.In addition, the inner tube guide member is formed so as to protrude in the shape of a nozzle from the center of the front end of the device housing is inserted into the endometrial tube to transmit plasma energy.
이로써, 저온대기압 플라즈마 에너지는 자궁외경관으로 집중되도록 하고, 대기압 플라즈마 제트는 자궁내경관으로 집중되게 가이드 하여 치료효과를 높일 수 있다.As a result, the low-temperature atmospheric pressure plasma energy is concentrated in the endometrial canal, and the atmospheric pressure plasma jet is guided to the endometrial canal to increase the therapeutic effect.
또한, 상기 외경관 가이드부재는, 상기 장치 하우징의 선단에 결합되는 결합부; 및 상기 결합부에서 확장 형성되어 자궁외경관을 감싸도록 형성되는 확장리브;를 포함하는 것이 좋다.In addition, the outer diameter pipe guide member, the coupling portion coupled to the front end of the device housing; And expansion ribs formed to expand in the coupling part and surround the uterine cervix.
또한, 상기 장치 하우징 내부에 설치되어 상기 제1 및 제2플라즈마 발생모듈을 격리하는 내부 구조물을 더 포함하는 것이 좋다.The apparatus may further include an internal structure installed inside the device housing to isolate the first and second plasma generating modules.
이로써, 하나의 장치 하우징에 서로 독립적으로 구동되는 제1 및 제2플라즈마 발생모듈을 설치할 수 있다.As a result, the first and second plasma generating modules driven independently of each other may be installed in one device housing.
또한, 상기 내부 구조물은 석영관을 포함하며, 상기 석영관과 상기 장치 하우징 사이에 상기 제1플라즈마 발생모듈의 플라즈마 발생부로 가스를 공급하는 가스 공급경로가 형성되는 것이 좋다.The internal structure may include a quartz tube, and a gas supply path may be formed between the quartz tube and the device housing to supply gas to the plasma generator of the first plasma generating module.
본 발명의 자궁경부암 치료용 플라즈마 치료장치에 의하면, 플라즈마 에너지를 이용하여 자궁경부암 치료를 효과적으로 할 수 있다.According to the plasma treatment apparatus for cervical cancer treatment of the present invention, it is possible to effectively treat cervical cancer using plasma energy.
특히, 발생된 플라즈마를 치료목적 부위로 집중되도록 하는 가이드부를 구비함으로써, 치료목적 부분의 암세포를 효과적으로 박멸할 수 있다.In particular, by providing a guide portion to concentrate the generated plasma to the treatment site, it is possible to effectively eradicate cancer cells of the treatment area.
또한, 자궁외경관은 대면적 플라즈마 발생기를 이용하여 넓은 면적의 부위를 치료하고, 자궁내경관은 플라즈마 제트를 이용하여 집중적으로 치료할 수 있도록 복합적일 치료장치를 제공함으로써, 자궁외경관과 자궁내경관을 하나의 치료장치를 이용하여 동시에 치료할 수 있는 이점이 있다.In addition, the uterine cervix can treat a large area using a large-area plasma generator, and the endometrial canal is provided with a complex treatment device for intensive treatment using a plasma jet. There is an advantage that can be treated at the same time using the treatment device.
또한, 외경관 가이드부재와 내경관 가이드부재를 하나의 치료장치에 구비함으로써, 플라즈마 에너지를 자궁외경관 및 자궁내경관 각각으로 집중되도록 하여 치료효과를 향상시킬 수 있다.In addition, by providing the outer tube guide member and the inner tube guide member in one treatment device, plasma energy can be concentrated in the uterine cervix and the endometrial tube, thereby improving the therapeutic effect.
도 1은 본 발명의 제1실시예에 따른 자궁경부암 치료용 플라즈마 치료장치를 나타내 보인 개략적인 구성도이다.1 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a first embodiment of the present invention.
도 2 및 도 3은 도 1에 도시된 플라즈마 발생부를 발췌하여 설명하기 위한 개략적인 도면이다.2 and 3 are schematic views for explaining and extracting the plasma generating unit shown in FIG.
도 4는 도 1에 도시된 플라즈마 치료장치를 이용하여 자궁외경관을 치료하는 상태를 설명하기 위한 도면이다.4 is a view for explaining a state of treating the endometrial tube using the plasma treatment apparatus shown in FIG.
도 5는 본 발명의 제2실시예에 따른 자궁경부암 치료용 플라즈마 치료장치를 나타내 보인 개략적인 구성도이다.Figure 5 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a second embodiment of the present invention.
도 6은 도 5에 도시된 플라즈마 치료장치를 이용하여 자궁내경관을 치료하는 과정을 설명하기 위한 도면이다.FIG. 6 is a view for explaining a process of treating an endometrial canal using the plasma treatment apparatus shown in FIG. 5.
도 7은 본 발명의 제3실시예에 따른 자궁경부암 치료용 플라즈마 치료장치를 나타내 보인 개략적인 구성도이다.7 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a third embodiment of the present invention.
도 8은 본 발명의 제4실시예에 따른 자궁경부암 치료용 플라즈마 치료장치를 나타내 보인 개략적인 구성도이다.8 is a schematic diagram showing a plasma treatment apparatus for treating cervical cancer according to a fourth embodiment of the present invention.
도 9는 도 8에 도시된 자궁경부암 치료용 플라즈마 치료장치를 이용하여 자궁경부를 치료하는 과정을 설명하기 위한 개략적인 도면이다.FIG. 9 is a schematic diagram illustrating a process of treating the cervix using the plasma treatment apparatus for treating cervical cancer shown in FIG. 8.
이하, 첨부된 도면을 참조하여 본 발명의 바람직한 실시예에 의한 자궁경부암 치료용 플라즈마 치료장치를 자세히 설명하기로 한다.Hereinafter, a plasma treatment apparatus for treating cervical cancer according to a preferred embodiment of the present invention with reference to the accompanying drawings will be described in detail.
도 1 내지 도 4를 참조하면, 본 발명의 제1실시예에 따른 자궁경부암 치료용 플라즈마 치료장치(100)는, 장치 하우징(110)과, 장치 하우징(110)의 선단부로 플라즈마 에너지를 발생시키는 플라즈마 발생부(120), 발생된 플라즈마 에너지를 치료할 자궁경부 측으로 가이드 하는 플라즈마 가이드부(130)를 구비한다.1 to 4, the plasma treatment apparatus 100 for treating cervical cancer according to the first embodiment of the present invention may generate plasma energy to the device housing 110 and the tip of the device housing 110. The plasma generating unit 120, and the plasma guide unit 130 for guiding the generated plasma energy to the cervix side to be treated.
상기 장치 하우징(110)은 절연성 재질로 형성되며, 소정 길이를 가지는 관 형상을 가진다. 바람직하게는 장치 하우징(110)은 자궁경부를 치료하기 위한 목적으로 자궁의 질 내부로 진입될 수 있는 충분한 길이를 가지며, 원형의 관 구조를 갖는 것이 좋다.The device housing 110 is formed of an insulating material and has a tubular shape having a predetermined length. Preferably, the device housing 110 has a sufficient length to enter the vagina of the uterus for the purpose of treating the cervix, and preferably has a circular tubular structure.
상기 장치 하우징(110)의 내부에는 가스 공급경로(111)가 형성되어 장치 하우징(110)의 선단에 설치되는 플라즈마 발생부(120)로 가스를 공급할 수 있다. 가스 공급경로(111)는 장치 하우징(110)과 장치 하우징(110) 내부에 설치되는 내부 구조물(113) 사이에 형성될 수 있다. 상기 내부 구조물(113)은 절연성 재질로 형성될 수 있으며, 일예로서 석영관을 포함할 수도 있다.A gas supply path 111 may be formed in the device housing 110 to supply gas to the plasma generator 120 installed at the tip of the device housing 110. The gas supply path 111 may be formed between the device housing 110 and the internal structure 113 installed inside the device housing 110. The internal structure 113 may be formed of an insulating material, and may include, for example, a quartz tube.
상기 플라즈마 발생부(120)의 일예로는 소위 DBD() 플라즈마 발생방식의 구조를 가질 수 있다. 즉, 도 1, 도 2 및 도 3에 도시된 바와 같이, 플라즈마 발생부(120)는 장치 하우징(110)의 선단에 설치되는 것으로서, 글라스 기판(121) 상에 설치되는 제1전극(123)과, 제2전극(125), 제1 및 제2전극(123,125)을 절연하도록 기판(121)상에 설치되는 유전체(127)를 포함할 수 있다. 상기 글라스 기판(121)에는 가스를 전극(123,125) 쪽으로 공급하기 위한 가스 공급유로(h)가 미세하게 형성될 수 있다. 기판(121)에 형성되는 제1 및 제2전극(123,125)은 반도체 제조 공정에 의해 적층되어 형성될 수 있으며, 다양한 패턴으로 형성될 수 있다. 예를 들어, 제2전극(125)이 메쉬구조의 패턴으로 형성되고, 그 메쉬구조의 제2전극(125) 사이에 제1전극(123)에 형성될 수 있다. 물론, 기판(121)에 형성되는 가스 공급유로(가스홀;h)도 반도체 제조공정을 통해 형성될 수 있다. 상기 유전체(127)는 제1 및 제2전극(123,125)을 덮도록 형성되며, 외부와의 전기적 차단을 하고, 플라즈마가 효과적으로 방전되도록 소정 두께로 형성된다.As an example of the plasma generation unit 120 may have a structure of a so-called DBD () plasma generation method. That is, as shown in FIGS. 1, 2, and 3, the plasma generating unit 120 is installed at the tip of the device housing 110, and the first electrode 123 is installed on the glass substrate 121. And a dielectric 127 provided on the substrate 121 to insulate the second electrode 125 and the first and second electrodes 123 and 125. A gas supply passage h may be minutely formed in the glass substrate 121 to supply gas toward the electrodes 123 and 125. The first and second electrodes 123 and 125 formed on the substrate 121 may be stacked and formed by a semiconductor manufacturing process, and may be formed in various patterns. For example, the second electrode 125 may be formed in a pattern of a mesh structure, and may be formed on the first electrode 123 between the second electrodes 125 of the mesh structure. Of course, the gas supply passage (gas hole) h formed in the substrate 121 may also be formed through a semiconductor manufacturing process. The dielectric 127 is formed to cover the first and second electrodes 123 and 125, and is formed to have a predetermined thickness so as to electrically cut off the outside and discharge the plasma effectively.
또한, 상기 유전체(127)의 외측에는 2차 전자생성층(128)과 수화방지막(129)이 차례로 적층되어 더 형성될 수 있다. 이러한 2차 전자생성층(128) 및 수화방지막(129)은 상기 유전체(127)와 전극(123,125)과 같이 반도제 제조공정에 의해 형성될 수 있다. 2차 전자생성층(128)은 발생한 플라즈마로부터 더 많은 전하를 재생성하는 역할을 할 수 있다. 이러한 2차 전자생성층(128)은 선택적으로 적용할 수 있다. 이러한 구성의 플라즈마 발생부(120)는 면적에 제약을 받지 않고 원하는 면적으로 면 방전구조로 형성할 수 있으며, 전극형성은 반도체 제조기술(폴토리소그래피 기술)로 제작이 가능하여 미세 전극 구조를 만들 수 있어, 저전력으로도 고 밀도 플라즈마를 발생시킬 수 있다.In addition, the secondary electron generation layer 128 and the hydration prevention layer 129 may be sequentially stacked on the outer side of the dielectric 127 to be further formed. The secondary electron generation layer 128 and the anti-hydration layer 129 may be formed by a semiconductor manufacturing process such as the dielectric 127 and the electrodes 123 and 125. The secondary electron generation layer 128 may serve to regenerate more charge from the generated plasma. The secondary electron generation layer 128 may be selectively applied. The plasma generating unit 120 having such a configuration can be formed as a surface discharge structure with a desired area without being restricted by the area, and electrode formation can be made by semiconductor manufacturing technology (potolithography technology) to make a fine electrode structure. Thus, high density plasma can be generated even at low power.
상기 구성의 플라즈마 발생부(120)는 상기 제1 및 제2전극(123,125)에 교류전압을 인가하면서 상기 가스 공급경로(111)를 통해 가스를 공급하면, 제1 및 제2전극(123,125) 사이에서 플라즈마가 생성된다.When the plasma generator 120 of the above configuration supplies gas through the gas supply path 111 while applying an alternating voltage to the first and second electrodes 123 and 125, the first and second electrodes 123 and 125 are disposed between the first and second electrodes 123 and 125. In the plasma is generated.
여기서, 상기 제1 및 제2전극(123,125) 간이 간격이 대략 100~400㎛인 것이 바람직하며, 방전 전압은 1kV 이하이고, 방전 전류는 10mA 이하의 특성을 갖도록 설정되는 것이 바람직하다.Here, it is preferable that the interval between the first and second electrodes 123 and 125 is approximately 100 to 400 μm, the discharge voltage is set to 1 kV or less, and the discharge current is set to have a characteristic of 10 mA or less.
또한, 상기에서 설명한 플라즈마 발생부(120)는 일예에 불과하면, 다양한 구성의 공지의 DBD 플라즈마 방식이 적용될 수 있음은 당연하다.In addition, if the above-described plasma generating unit 120 is only one example, it is obvious that a known DBD plasma method of various configurations may be applied.
상기 플라즈마 가이드부(130)는 플라즈마 생성부(120)에서 생성된 플라즈마 에너지를 도 4에 도시된 바와 같이, 치료할 목적 인체부위인 자궁외경관(extocervix;10) 쪽으로 가이드 하기 위한 것이다. 이러한 플라즈마 가이드부(130)의 일례로는 장치 하우징(110)의 선단에 연결되어 생성된 플라즈마를 자궁경부의 자궁외경관(10)으로 가이드하기 위한 외경관 가이드부재(131)를 구비한다.As shown in FIG. 4, the plasma guide unit 130 guides the plasma energy generated by the plasma generating unit 120 toward the uterine external cervix (extocervix) 10, which is a target human body to be treated. One example of the plasma guide unit 130 includes an outer tube guide member 131 for guiding the generated plasma connected to the distal end of the device housing 110 to the uterine cervix 10 of the cervix.
상기 외경관 가이드부재(131)는 장치 하우징(110)의 선단에 결합되는 결합부(131a)와, 결합부(131a)에서 확장형성되어 자궁경부의 외경관을 감싸도록 형성되는 확장리브(131b)를 구비한다. 결합부(131a)는 원통 구조를 가지며, 장치 하우징(110)의 선단의 외측테두리에 결합될 수 있다. 상기 확장리브(131b)는 결합부(131a)와 일체로 형성되며, 결합부(131a)로부터 점진적으로 직경이 확장되어 연장 된다. 이러한 구성의 확장리브(131b)는 자궁외경관(10)을 감싸서 모아주게 됨으로써, 플라즈마 발생부(120)에서 생성된 플라즈마 에너지가 자궁외경관(10)으로 집중될 수 있도록 효과적으로 가이드 할 수 있다. 따라서 자궁외경관(10)의 암세포를 효과적으로 사멸하여 치료할 수 있게된다.The outer diameter tube guide member 131 is a coupling portion 131a coupled to the front end of the device housing 110 and an expansion rib 131b extending to the coupling portion 131a to surround the outer diameter tube of the cervix. It is provided. The coupling part 131a has a cylindrical structure and may be coupled to an outer edge of the front end of the device housing 110. The expansion rib 131b is integrally formed with the coupling portion 131a and gradually extends in diameter from the coupling portion 131a. The expansion rib 131b having such a configuration may be effectively guided so that the plasma energy generated by the plasma generator 120 may be concentrated on the uterine cervix 10 by wrapping and collecting the uterine outer tube 10. Therefore, cancer cells of the uterine cervix can be effectively killed and treated.
또한, 도 5 및 도 6을 참조하면, 본 발명의 제2실시예에 따른 플라즈마 치료장치(100')는, 플라즈마 가이드부(130')로서 자궁내경관(endocervical cannal;20)으로 플라즈마 에너지가 집중되도록 가이드 할 수 있는 구조를 가지는 내경관 가이드부재(133)를 구비하는데 특징이 있다. 상기 내경관 가이드부재(133)는 장치 하우징(110)의 선단에 결합되는 결합부(133a)와, 상기 결합부(133a)에서 깔때기 형상으로 그 직경이 점진적으로 감소하면서 연장된 연결가이드부(133b) 및 연결가이드부(133b)에서 관 형상으로 연장된 노즐 가이드부(133c)를 가진다.5 and 6, the plasma treatment apparatus 100 ′ according to the second embodiment of the present invention has plasma energy as an endocervical cannal 20 as the plasma guide unit 130 ′. It is characterized by having an inner diameter guide member 133 having a structure capable of guiding to be concentrated. The inner diameter guide member 133 has a coupling portion 133a coupled to the front end of the device housing 110 and a connection guide portion 133b extending in a funnel shape from the coupling portion 133a and gradually decreasing in diameter. ) And a nozzle guide portion 133c extending in a tubular shape from the connection guide portion 133b.
상기 결합부(133a)는 장치 하우징(110)의 선단의 외측에 결합되며, 바람직하게는 착탈 가능하게 결합될 수도 있다. 결합부(133a)에서 연결가이드부(133b)가 일체로 소정 거리 연장되며, 지름이 점진적으로 감소하여 깔때기모양으로 연장된다. 그리고 연결가이드부(133b)의 단부에서 노즐 가이드부(133c)가 동일 직경의 관 형상으로 연장된다. 이러한 구성의 노즐 가이드부(133c)는 자궁내경관으로 삽입되어, 그 자궁내경관(20)으로 플라즈마 에너지가 집중되도록 함으로써, 자궁내경관(20) 측의 암세포를 효과적으로 사멸하여 치료할 수 있게 된다.The coupling portion 133a is coupled to the outer side of the front end of the device housing 110, preferably may be detachably coupled. In the coupling portion 133a, the connection guide portion 133b is integrally extended at a predetermined distance, and the diameter is gradually reduced to extend in a funnel shape. And the nozzle guide part 133c extends in the tubular shape of the same diameter at the edge part of the connection guide part 133b. The nozzle guide portion 133c having such a configuration is inserted into the endometrial canal so that plasma energy is concentrated in the uterine canal 20, thereby effectively killing and treating cancer cells on the endometrial canal 20 side.
한편, 앞서 설명한 외경관 가이드부재(131)와 내경관 가이드부재(133)는 장치 하우징(110)의 선단에 일체로 형성될 수도 있으나, 스크류 체결방식 등에 의해 교환 장착 가능한 구조를 가질 수도 있다. 따라서 치료부위에 따라서 외경관 가이드부재(131)와 내경관 가이드부재(133)를 선택적으로 채용하여 사용할 수 있다.On the other hand, the outer diameter guide member 131 and the inner diameter guide member 133 described above may be integrally formed at the front end of the device housing 110, it may have a structure that can be replaced by a screw fastening method. Therefore, the outer diameter guide member 131 and the inner diameter guide member 133 may be selectively employed according to the treatment area.
도 7을 참조하면, 본 발명의 제3실시예에 따른 자궁경부 치료용 플라즈마 치료장치(200)는, 장치 하우징(201)과, 장치 하우징(201)에 설치되어 자궁외경관을 치료하기 위한 제1플라즈마 발생모듈(210) 및 자궁내경관을 치료하기 위한 제2플라즈마 발생모듈(220)을 구비한다.Referring to FIG. 7, the plasma treatment apparatus 200 for cervical treatment according to the third embodiment of the present invention may be installed in the device housing 201 and the device housing 201 to treat the uterine cervix. A plasma generating module 210 and a second plasma generating module 220 for treating the endometrial canal are provided.
상기 제1플라즈마 발생모듈(210)은 장치 하우징(201)의 내부에서 선단 쪽으로 가스를 공급하는 가스 공급경로(211)과, 장치 하우징(201)의 선단의 일정 정역에서 플라즈마를 발생시키도록 설치되는 제1플라즈마 발생부(213)를 구비한다.The first plasma generating module 210 is installed to generate a plasma in a constant region of the front end of the device housing 201 and the gas supply path 211 for supplying gas toward the front end of the device housing 201 The first plasma generating unit 213 is provided.
장치 하우징(201)의 내부에는 원통형의 내구 구조물(215)이 제1플라즈마 발생부(213)까지 연장 설치된다. 내부 구조물(215)은 석영관을 포함할 수 있으며, 이외에도 절연성 재질로 형성된 절연파이프를 포함할 수 있다. 이러한 절연파이프의 내부를 통해 전원을 제1플라즈마 발생부(213)로 공급할 수 있는 전극 내지 전선케이블이 설치될 수 있다. 내부 구조물(215)과 장치 하우징(201) 사이로 가스가 공급되는 상기 가스 공급경로(211)가 마련된다.The cylindrical durable structure 215 extends to the first plasma generating unit 213 inside the device housing 201. The internal structure 215 may include a quartz tube and may further include an insulation pipe formed of an insulating material. An electrode or an electric wire cable capable of supplying power to the first plasma generator 213 through the inside of the insulation pipe may be installed. The gas supply path 211 is provided through which gas is supplied between the internal structure 215 and the device housing 201.
상기 제1플라즈마 발생부(213)는 장치 하우징(201)의 선단부에 설치되며, 중앙부분을 제외한 외곽부분에서 플라즈마를 발생하도록 설치된다. 이러한 제1플라즈마 발생부(213)는 앞서 도 2 및 도 3을 통해 설명한 플라즈마 발생부(120)의 구성과 동일한 구성을 가질 수 있다. 다만, 장치 하우징(201)의 선단부의 중앙부분에는 상기 제2플라즈마 발생모듈(220)이 설치되므로, 제2플라즈마 발생모듈(220)의 중심을 기준으로 그 주변에 제1플라즈마 발생부(213)가 설치된다. 상기 제1플라즈마 발생부(213)에서 발생하는 플라즈마는 자궁외경관(10)을 치료하는데 사용된다.The first plasma generating unit 213 is installed at the front end of the device housing 201, and is installed to generate plasma at the outer portion except the center portion. The first plasma generator 213 may have the same configuration as that of the plasma generator 120 described above with reference to FIGS. 2 and 3. However, since the second plasma generating module 220 is installed at the central portion of the front end of the device housing 201, the first plasma generating unit 213 is disposed around the center of the second plasma generating module 220. Is installed. The plasma generated by the first plasma generator 213 is used to treat the uterine cervix 10.
상기 제2플라즈마 발생모듈(220)은 상기 내부구조물(215)의 내부에 설치되는 것으로서, 바람직하게는 대기압 플라즈마를 제트 방식으로 방전시키는 소위 플라즈마 제트인 것이 좋다. 이러한 플라즈마 제트는 특정 부분에 대기압 플라즈마를 집중적으로 발생시킬 수 있으며, 따라서 자궁내경관(20) 쪽으로 플라즈마를 집중하여 방전시킴으로써 자궁내경관(20)의 암세포를 사멸하는데 효과를 볼 수 있다. 이러한 제2플라즈마 발생모듈(220)은 공지의 플라즈마 제트의 구성을 가질 수 있으며, 제1플라즈마 발생모듈(210)과 절연상태를 유지하도록 제1플라즈마 발생모듈(210)의 중심부분에 설치된다.The second plasma generation module 220 is installed inside the internal structure 215, and preferably, a so-called plasma jet for discharging the atmospheric plasma in a jet manner. Such a plasma jet can generate atmospheric pressure intensively in a specific portion, and thus, by focusing and discharging the plasma toward the endometrial canal 20, it can be effective in killing cancer cells of the endometrial canal 20. The second plasma generation module 220 may have a configuration of a known plasma jet, and is installed at a central portion of the first plasma generation module 210 to maintain an insulation state with the first plasma generation module 210.
상기 제2플라즈마 발생모듈(220)의 일예가 도 8에 도시되어 있다. 도시된 제2플라즈마 발생모듈(220)은 석영관(221)을 사이에 두고 외부의 접지전극(222)과 내부전극(223)이 설치된 구성을 가질 수 있다. 내부 전극(223)의 일단으로 가스가 공급되면, 내부전극(223)의 타단의 너희 부분(223a)에서 외부의 접지전극(222)과의 간극에 의해 플라즈마가 발생된다. 이러한 구성은 가는 관 형상으로 형성되어, 상기 장치 하우징(201)의 내부의 내부 구조물(215)의 내부에 설치된다. 따라서 제2플라즈마 발생모듈(220)의 선단에서 발생하는 플라즈마 제트는 장치 하우징(201)의 선단의 중심에서 집중적으로 발생하여 자궁내경관(20)의 입구 쪽에 집중되도록 할 수 있다.An example of the second plasma generation module 220 is illustrated in FIG. 8. The illustrated second plasma generation module 220 may have a configuration in which an external ground electrode 222 and an internal electrode 223 are installed with a quartz tube 221 interposed therebetween. When gas is supplied to one end of the internal electrode 223, plasma is generated by a gap with the external ground electrode 222 at your portion 223a at the other end of the internal electrode 223. This configuration is formed in a thin tubular shape, and is installed inside the internal structure 215 inside the device housing 201. Therefore, the plasma jet generated at the tip of the second plasma generating module 220 may be concentrated at the center of the tip of the device housing 201 to be concentrated at the inlet side of the endometrial tube 20.
그리고 플라즈마 제트 주변에서는 상기 제1플라즈마 발생부(210)에서 발생하는 플라즈마가 자궁외경관(20)에 집중되도록 함으로써, 자궁외경관(10)의 암세포를 사멸하는데 사용된다.In the vicinity of the plasma jet, the plasma generated by the first plasma generator 210 is concentrated on the uterine cervix 20, and used to kill cancer cells of the ectopic tube 10.
이와 같이, 본 발명의 제3실시에 따른 자궁 경부암 치료용 플라즈마 치료장치(200)에 의하면, DBD(Dielectric Barrier Discharge, 유전체 장벽 방전) 플라즈마와 플라즈마 제트(jet)를 혼합한 소위 하이브리드 플라즈마 치료기기로서, 복합적인 플라즈마 에너지를 발생하여 자궁외경관(10)과 자궁내경관(20)의 전암병변을 동시에 치료할 수 있다.As described above, according to the plasma treatment apparatus 200 for treating cervical cancer according to the third embodiment of the present invention, a so-called hybrid plasma treatment apparatus in which DBD (Dielectric Barrier Discharge) plasma and plasma jet are mixed is used. By generating complex plasma energy, precancerous lesions of the endometrial tube 10 and the endometrial tube 20 can be treated simultaneously.
또한, 도 9 및 도 10을 참조하면, 본 발명의 제4실시예에 따른 자궁경부암 치료용 플라즈마 치료장치(200')에 따르면, 장치 하우징(201)과, 장치 하우징(201)에 설치되는 제1 및 제2플라즈마 발생모듈(210)(220) 및 플라즈마 가이드부(230)를 구비한다.9 and 10, according to the plasma treatment apparatus 200 ′ for cervical cancer treatment according to the fourth embodiment of the present invention, a device installed in the device housing 201 and the device housing 201 is provided. First and second plasma generation module 210, 220 and the plasma guide unit 230 is provided.
여기서, 상기 제1 및 제2플라즈마 발생모듈(210)(220)은 앞서 도 7 및 도 8을 통해 자세히 설명하였으므로, 더 이상의 설명은 생략한다.Here, since the first and second plasma generation module 210, 220 has been described in detail with reference to Figures 7 and 8, further description thereof will be omitted.
상기 플라즈마 가이드부(230)는 외경관 가이드부재(231)와, 내경관 가이드부재(233)를 구비한다.The plasma guide unit 230 includes an outer diameter guide member 231 and an inner diameter guide member 233.
외경관 가이드부재(231)는 제1플라즈마 발생모듈(210)에서 발생된 플라즈마 에너지를 자궁외경관(10)으로 향하도록 가이드 하는 역할을 한다. 이러한 외경관 가이드부재(213)는 앞서 도 1을 통해 설명한 외경관 가이드부재(131)와 동일한 구성을 가질 수 있다. 즉, 외경관 가이드부재(231)는 장치 하우징(201)의 선단부 외측테두리에 연결되며, 외측으로 확장되면서 연장되어 자궁외경관(10)을 감싸도록 지지하여 플라즈마가 자궁외경관(10)으로 집중되도록 하는 역할을 한다.The outer diameter guide member 231 serves to guide the plasma energy generated by the first plasma generating module 210 toward the uterine outer tube 10. The outer diameter guide member 213 may have the same configuration as the outer diameter guide member 131 described above with reference to FIG. 1. That is, the outer tube guide member 231 is connected to the outer edge of the front end of the device housing 201, and extends outward to support the outer uterine tube 10 so as to concentrate the plasma on the uterine tube 10. Play a role.
상기 내경관 가이드부재(233)는 제1플라즈마 발생모듈(210)과 제2플라즈마 발생모듈(220)의 경계부분에 설치되며, 소정 직경을 가지는 노즐형상을 가진다. 이러한 내경관 가이드부재(233)는 플라즈마 제트가 자궁내경관(20) 내측으로 집중되어 발생되도록 내경관 내부로 진입될 수 있는 정도의 직경을 가지며, 소정 길이로 형성되는 것이 좋다. 이러한 내경관 가이드부재(233)는 유전체로 형성될 수 있으며, 상기 제1플라즈마 발생모듈(210)의 유전체와 연결되어 일체로 형성될 수도 있다.The inner diameter guide member 233 is installed at a boundary between the first plasma generating module 210 and the second plasma generating module 220 and has a nozzle shape having a predetermined diameter. The inner diameter guide member 233 has a diameter enough to enter the inner diameter tube so that the plasma jet is concentrated to the inside of the uterine inner tube 20, it is preferably formed to a predetermined length. The inner diameter guide member 233 may be formed of a dielectric, and may be integrally formed by being connected to the dielectric of the first plasma generating module 210.
도 9에 도시된 바와 같은 플라즈마 치료장치(200')에 의하면, 도 10에 도시된 바와 같이, 자궁외경관(10)과 자궁내경관(20) 각각으로 발생된 플라즈마가 작용하도록 하여 각 부위에서의 전암병변을 효과적으로 치료할 수 있다. 특히, 내경관 가이드부재(233)는 자궁내경관(20)을 통과하여 그 자궁 내부까지 진입하여 내측의 전암병변으로 플라즈마가 직접 도달하도록 하여 암세포를 효과적으로 사멸하여 치료할 수 있게 된다.According to the plasma treatment apparatus 200 ′ as shown in FIG. 9, as shown in FIG. 10, the plasma generated by each of the endometrial tube 10 and the endometrial tube 20 acts on each site. It can effectively treat precancerous lesions. In particular, the inner tube guide member 233 passes through the endometrial tube 20 and enters the uterus to directly reach the inner precancerous lesion so that the cancer cells can be effectively killed and treated.
한편, 이와 같이 플라즈마 에너지를 이용하여 자궁경부 암세포를 사멸하되, 다른 정상 세포에 영향을 주지 않으면서도 암세포만을 사멸하는 효과에 대해서는 본 출원인이 기 출원한 출원번호 제10-2018-0028466호에 기재되어 있으므로 세포 사멸효과에 대한 자세한 설명은 생략하기로 한다.Meanwhile, the effect of killing cervical cancer cells using plasma energy as described above, but only killing cancer cells without affecting other normal cells, is described in Application No. 10-2018-0028466 filed by the present applicant. Therefore, detailed description of the cell death effect will be omitted.
이상, 본 발명을 본 발명의 원리를 예시하기 위한 바람직한 실시예와 관련하여 도시하고 설명하였으나, 본 발명은 그와 같이 도시되고 설명된 그대로의 구성 및 작용으로 한정되는 것이 아니다. 오히려 첨부된 특허청구범위의 사상 및 범위를 일탈함이 없이 본 발명에 대한 다수의 변경 및 수정이 가능함을 당업자들은 잘 이해할 수 있을 것이다.While the invention has been shown and described in connection with preferred embodiments for illustrating the principles of the invention, the invention is not limited to the construction and operation as shown and described. Rather, those skilled in the art will appreciate that many modifications and variations of the present invention are possible without departing from the spirit and scope of the appended claims.

Claims (16)

  1. 자궁경부를 치료하기 위해 질경 내에 진입될 수 있는 프로브 형의 장치 하우징과;A probe-type device housing capable of entering the planar cavity to treat the cervix;
    상기 장치 하우징의 선단으로 플라즈마 에너지를 발생시키는 플라즈마 발생부; 및A plasma generator for generating plasma energy at a tip of the device housing; And
    상기 장치 하우징의 선단부에 설치되어 상기 플라즈마 발생부에서 생성된 플라즈마를 자궁경부 쪽에 집중되도록 가이드 하는 플라즈마 가이드부;를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.And a plasma guide unit installed at the distal end of the device housing to guide the plasma generated by the plasma generating unit to be concentrated on the cervix side.
  2. 제1항에 있어서, 상기 플라즈마 가이드부는,The method of claim 1, wherein the plasma guide portion,
    상기 장치 하우징의 선단의 테두리로부터 확장되어 연장되어 자궁외경관을 감싸서 지지하는 외경관 가이드부재를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for cervical cancer treatment, characterized in that it extends from the rim of the front end of the device housing extends to surround the uterine cervix and support member.
  3. 제2항에 있어서, 상기 외경관 가이드부재는,According to claim 2, wherein the outer diameter guide member,
    상기 장치 하우징의 선단에 결합되는 결합부; 및A coupling part coupled to a front end of the device housing; And
    상기 결합부에서 확장 형성되어 자궁외경관을 감싸도록 형성되는 확장리브;를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for treating cervical cancer, characterized in that it comprises; expansion ribs formed to expand in the coupling portion to surround the cervical canal.
  4. 제1항에 있어서, 상기 플라즈마 가이드부는,The method of claim 1, wherein the plasma guide portion,
    상기 장치 하우징의 선단의 테두리로부터 점진적으로 좁아지도록 연장되어 자궁내경관으로 플라즈마 에너지가 집중되도록 가이드 하는 외경관 가이드부재를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for cervical cancer treatment, characterized in that it comprises an outer diameter guide member extending to gradually narrow from the edge of the front end of the device housing to guide the plasma energy to the endometrial canal.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서,The method according to any one of claims 1 to 4,
    상기 플라즈마 발생부는 저온대기압 유전체장벽(DBD;Dielectric Barrier Discharge) 플라즈마를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.The plasma generating unit plasma treatment apparatus for cervical cancer, characterized in that the low temperature atmospheric dielectric barrier (DBD; Dielectric Barrier Discharge) plasma.
  6. 자궁경부암을 치료하기 위해 질경 내에 진입될 수 있는 프로브 형의 장치 하우징;A probe-type device housing capable of entering into the planar body for treating cervical cancer;
    상기 장치 하우징에 설치되어 자궁외경관을 치료하기 위한 플라즈마를 발생시키는 제1플라즈마 발생모듈; 및A first plasma generating module installed in the device housing to generate plasma for treating the uterine cervix; And
    상기 장치 하우징에 설치되어 자궁내경관을 치료하기 위한 플라즈마를 발생시키는 제2플라즈마 발생모듈;을 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for cervical cancer treatment, comprising: a second plasma generating module installed in the device housing for generating a plasma for treating the cervical canal.
  7. 제6항에 있어서,The method of claim 6,
    상기 제2플라즈마 발생모듈은 상기 제1플라즈마 발생모듈에서 발생시키는 플라즈마 발생면의 중앙부분으로 플라즈마 에너지를 발생하도록 배치되는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치. The second plasma generation module is plasma treatment apparatus for cervical cancer treatment, characterized in that arranged to generate plasma energy to the central portion of the plasma generating surface generated by the first plasma generation module.
  8. 제6항에 있어서, 상기 제1플라즈마 발생모듈은,The method of claim 6, wherein the first plasma generating module,
    저온대기압 유전체장벽(DBD;Dielectric Barrier Discharge) 플라즈마를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for the treatment of cervical cancer, characterized in that it comprises a low-temperature atmospheric dielectric barrier (DBD; plasma).
  9. 제8항에 있어서, 상기 제2플라즈마 발생모듈은,The method of claim 8, wherein the second plasma generating module,
    상기 장치 하우징의 선단부의 중심부에서 플라즈마를 집중적으로 발생시킬 수 있는 저온 대기압 플라즈마 제트를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.And a low temperature atmospheric plasma jet capable of intensively generating plasma at a central portion of the distal end of the device housing.
  10. 제6항 내지 제9항 중 어느 한 항에 있어서,The method according to any one of claims 6 to 9,
    상기 장치 하우징에 설치되어 상기 제1 및 제2플라즈마 발생모듈에서 생성되는 플라즈마 에너지가 자궁경부로 집중되도록 가이드 하는 플라즈마 가이드부를 더 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.And a plasma guide unit installed in the device housing to guide the plasma energy generated by the first and second plasma generating modules to be concentrated on the cervix.
  11. 제10항에 있어서, 상기 플라즈마 가이드부는,The method of claim 10, wherein the plasma guide portion,
    상기 장치 하우징의 선단의 테두리에서 연장되어 자궁외경관으로 상기 제1플라즈마 발생부에서 생성된 플라즈마 에너지가 집중되도록 가이드 하는 외경관 가이드부재를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.And an outer diameter tube guide member extending from an edge of the front end of the device housing to guide the plasma energy generated in the first plasma generator to the uterine outer tube.
  12. 제11항에 있어서, 상기 플라즈마 가이드부는,The method of claim 11, wherein the plasma guide portion,
    상기 장치 하우징의 선단부 중앙부분에 연결되어 상기 제2플라즈마 발생모듈에서 생성된 플라즈마 에너지가 자궁내경관으로 집중되도록 가이드 하는 내경관 가이드부재를 더 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for cervical cancer treatment, characterized in that it further comprises an inner diameter guide member connected to the central portion of the front end of the device housing to guide the plasma energy generated in the second plasma generating module to the endometrial canal.
  13. 제12항에 있어서, 상기 내경관 가이드부재는,The inner diameter guide member of claim 12,
    상기 장치 하우징의 선단 중앙에서 노즐형상으로 돌출 연장되어 상기 자궁내경관 내부로 삽입되어 플라즈마 에너지를 전달할 수 있도록 형성된 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment device for cervical cancer treatment, characterized in that the protruding extension in the shape of a nozzle in the center of the front end of the device housing is inserted into the endometrial canal to deliver plasma energy.
  14. 제11항에 있어서, 상기 외경관 가이드부재는,The method of claim 11, wherein the outer diameter guide member,
    상기 장치 하우징의 선단에 결합되는 결합부; 및A coupling part coupled to a front end of the device housing; And
    상기 결합부에서 확장 형성되어 자궁외경관을 감싸도록 형성되는 확장리브;를 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치. Plasma treatment device for treating cervical cancer, characterized in that it comprises; expansion ribs formed to expand in the coupling portion to surround the cervical canal.
  15. 제6항 내지 제9항 중 어느 한 항에 있어서,The method according to any one of claims 6 to 9,
    상기 장치 하우징 내부에 설치되어 상기 제1 및 제2플라즈마 발생모듈을 격리하는 내부 구조물을 더 포함하는 것을 특징으로 하는 자궁경부암 치료용 플라즈마 치료장치.Plasma treatment apparatus for cervical cancer treatment, characterized in that it further comprises an internal structure installed inside the device housing to isolate the first and second plasma generating module.
  16. 제15항에 있어서,The method of claim 15,
    상기 내부 구조물은 석영관을 포함하며,The inner structure includes a quartz tube,
    상기 석영관과 상기 장치 하우징 사이에 상기 제1플라즈마 발생모듈의 플라즈마 발생부로 가스를 공급하는 가스 공급경로가 형성되는 것을 특징으로 하는 자궁경부암 플라즈마 치료장치.And a gas supply path for supplying gas to the plasma generating unit of the first plasma generating module between the quartz tube and the device housing.
PCT/KR2018/009390 2018-03-16 2018-08-16 Plasma therapy device for treatment of cervical cancer WO2019177211A1 (en)

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Publication number Priority date Publication date Assignee Title
KR102651635B1 (en) * 2021-06-16 2024-03-27 주식회사 아이비엠솔 A plasma generating module for cervix
KR102651636B1 (en) * 2021-06-16 2024-03-27 주식회사 아이비엠솔 A plasma generating apparatus for cervix

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100054368A (en) * 2008-11-14 2010-05-25 주식회사 피에스엠 Plasma gun for medical treatment
KR20150146253A (en) * 2014-06-23 2015-12-31 광운대학교 산학협력단 Plasma Jet Devices with Electric Safty and Heat-Dissipation
KR20160062174A (en) * 2013-10-14 2016-06-01 디엔에이 리서치 센터 (엠) 에스디엔 비에이치디 Exocervical and endocervical cell sampling device
KR20170125447A (en) * 2016-05-04 2017-11-15 동아대학교 산학협력단 Selective apoptosis cancer cells using non thermal plasma jet device and tumor treatment using the same
US20180055561A1 (en) * 2011-03-25 2018-03-01 Minerva Surgical, Inc. System and method for endometrial ablation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8292935B2 (en) * 2006-09-12 2012-10-23 Bistitec Pharma Marketing Ltd Photonic device and method for treating cervical dysplasia
KR101248668B1 (en) 2011-03-10 2013-03-28 부산대학교 산학협력단 Method for controlling cell proliferation by using a non-thermal atmospheric pressure plasma exposure
DE102013113941B4 (en) * 2013-12-12 2015-07-23 Reinhausen Plasma Gmbh Arrangement for the treatment of wounds
KR101592081B1 (en) 2014-01-13 2016-02-04 연세대학교 산학협력단 Selective apoptosis of p53 deficient cancer cells or drug resistant cancer cells using non-thermal atmospheric pressure plasma
KR101626897B1 (en) * 2014-10-13 2016-06-02 서울대학교 산학협력단 Apparatuses of minimally invasive plasma generating device with coolant inducement in multi-tip electrode

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100054368A (en) * 2008-11-14 2010-05-25 주식회사 피에스엠 Plasma gun for medical treatment
US20180055561A1 (en) * 2011-03-25 2018-03-01 Minerva Surgical, Inc. System and method for endometrial ablation
KR20160062174A (en) * 2013-10-14 2016-06-01 디엔에이 리서치 센터 (엠) 에스디엔 비에이치디 Exocervical and endocervical cell sampling device
KR20150146253A (en) * 2014-06-23 2015-12-31 광운대학교 산학협력단 Plasma Jet Devices with Electric Safty and Heat-Dissipation
KR20170125447A (en) * 2016-05-04 2017-11-15 동아대학교 산학협력단 Selective apoptosis cancer cells using non thermal plasma jet device and tumor treatment using the same

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