WO2019017532A1 - Treatment system for acne disease and operation method thereof - Google Patents

Abstract

The present invention relates to a treatment system for acne disease and an operation method thereof, and the treatment system for acne disease integrally comprises: a microneedle high-frequency handpiece; and a handpiece for irradiating light rays. The operation method comprises the steps of: bringing the microneedle high-frequency handpiece into contact with skin to be treated by a practioner and applying a high-frequency voltage to a high-frequency generator; and bringing the handpiece for irradiating light rays into contact with a high-frequency irradiated portion after the operation of the microneedle high-frequency handpiece is completed using an optical air pressure treatment unit, and applying a pulse light ray irradiation voltage to a pulse light ray irradiation generator. Accordingly, the present invention has an effect of treating acne and improving acne prone skin.

Description

Acne disease treatment system and its operation method

The present invention relates to a system and a method for treating acne diseases, and more particularly, to a method and a system for treating acne disease, and more particularly, to a method for treating acne disease, The present invention relates to an acne disease treatment system and a method of operating the same.

The skin that covers our entire body consists of three layers: the epidermal layer, the dermal layer, and the subcutaneous fat layer. On the other hand, chronic inflammatory diseases of the hair follicle gland are various skin changes such as cotton papules, papules, blisters, nodules, and false cysts, resulting in a concave scar or enlarged scars. Acne is a disease that occurs in the face, neck, chest, where sebaceous glands are gathered, and inflammation occurs in sebaceous glands attached to hair follicles. Acne usually appears in puberty, but acne occurring in puberty continues until after age 25, or in the late 20s, is called adult acne. Adult acne is more likely to leave scar rather than adolescence and early treatment is important.

It is divided into the medicine to treat acne, the medicine to eat, and the surgical treatment. Surgical treatment includes injection therapy for symptomatic areas, acne extrusion therapy, and peeling. If acne is squeezed excessively, scarring is often left after treatment, so acne scar treatment is necessary.

The high frequency current causes very little ion motion because of the very short amplitude of vibration when the body tissue is energized, and does not cause electrochemical reaction or electrolysis phenomenon. In addition, heat energy can be generated, which can lead to an additional effect of increasing cell function and increasing blood flow. In the dermatology treatment, high frequency is widely used in various fields such as acne treatment, wrinkle lifting, scar treatment by acne, injection of a filler, etc. However, in a conventional high frequency treatment system for skin treatment, There has been a problem in causing the patient to suffer from high-frequency radiation errors in performing the treatment.

Korean Patent Laid-Open No. 10-2015-0007938 " Skin treatment apparatus " is disclosed.

On the other hand, a surgical procedure using an IPL (Intense Pulsed Light) has been developed. Refers to a laser that treats pigmented diseases or vascular diseases such as facial flushing, spots, freckles, and dullness by periodically generating light of a strong wavelength. Unlike conventional short wavelength lasers, pulsed light irradiation laser therapy apparatus can emit light of various wavelengths in a strong pulse form, and can treat diseases such as capillary vasodilation, pigmentation, and enlargement of pores.

Conventional devices are required to treat with acne treatment separately. Therefore, it is impossible to perform the combined treatment unless the equipment is fully equipped. Also, it is necessary to perform the treatment with a separate device to replace the equipment or to move the patient to the equipment position. There is.

SUMMARY OF THE INVENTION The present invention has been made to solve the problems of the prior art, and it is an object of the present invention to provide a microneedle RF treatment portion and an Intense Pulse Light (IPL) ), A photopneumatic treatment portion having a photopneumatic treatment portion is used to sequentially treat the treatment site, and a high-frequency treatment for stimulating the skin inserted into the skin of the patient and a high frequency treatment The present invention provides an acne disease treatment system for treating moderate to severe acne in an adult, and a method of operating the same.

The above object of the present invention can be achieved by an acne disease treatment system comprising a microneedle high frequency handpiece and a light beam manipulating handpiece integrally.

According to another aspect of the present invention, there is provided a method for treating acne disease comprising the steps of: applying a high-frequency voltage to a microneedle high-frequency handpiece in a high frequency generator of the microneedle RF processor in one step; And after the operation of the microneedle high frequency handpiece is completed in the second step, the pulse light irradiation unit of the optical air pressure treatment unit applies the pulse light irradiation voltage to the light beam manipulating handpiece ≪ / RTI >

In accordance with the present invention, the micro needle high frequency hand piece and the light beam manipulating hand piece are sequentially applied to the treatment area. In this step, acne is removed with a microneedle high frequency hand piece in one step, Which has an effect of improving acne skin by irradiation with pulsed light rays.

In addition, it is possible to easily replace the cartridge with a new one by separating the cartridge formed with the micro needles from the handle, to solve the difficulty of replacing the micro needles with new ones, and to replace them more hygienically, And it is possible to prevent the loss of the micro needle.

In addition, it can be cooled so as to prevent high temperature during the irradiation of pulsed light, so that treatment of skin diseases such as acne and foreign matters such as agriculture can be easily removed, skin burn can be prevented, and safety is significantly improved.

1 is a perspective view illustrating an acne disease treatment system according to an embodiment of the present invention,

FIG. 2 is a perspective view showing the inside of FIG. 1,

Figs. 3 and 4 are exploded perspective views of Fig. 1,

FIG. 5 is an exploded perspective view showing a microneedle high frequency handpiece of an acne disease treatment system according to an embodiment of the present invention,

FIG. 6 is a perspective view partially enlarged in FIG. 5,

FIG. 7 is an exploded perspective view showing a light-guiding handpiece of an acne disease treatment system according to an embodiment of the present invention,

FIG. 8 is a detailed exploded perspective view showing a light-guiding handpiece of an acne disease treatment system according to an embodiment of the present invention,

FIG. 9 is an engaging sectional view showing a light-guiding handpiece of an acne disease treatment system according to an embodiment of the present invention,

10 is a cross-sectional view of a low-frequency stimulation handpiece of an acne disease treatment system according to an embodiment of the present invention.

FIG. 11 is a system for treating an acne disease according to an embodiment of the present invention. FIG. 11 is a photograph showing the photographs observed using a dermoscopy using immunohistochemical staining for confirming skin irritation or damage after skin treatment of acne-induced rats,

FIG. 12 is a graph showing the results of an acne disease treatment system according to an embodiment of the present invention, using a rabbit ear acne model at 1 day, 3 days, and 5 days after acne induction, Photographs were taken with a microscope.

13 is a graph showing the volume of elevations,

14 is a graph showing elevation-affecetd area values of acne,

15 is a graph showing elevation-maximum height values,

16 is a graph showing an average roughness value (Ra).

17 is a graph showing the root mean squared surface roughness (Rq)

FIG. 18 is a photograph showing the change of PPAR gamma (PPAR gamma) by using dermoscopy through immunohistochemical staining after acne induced using a rabbit ear acne model,

FIG. 19 is a photograph showing changes in tumor necrosis factor alpha, TNF-alpha, or TNF using anthera-3D using immunohistochemical stain after acne-induced acne using a rabbit ear acne model,

FIG. 20 is a graph showing the results of visual observation, H & E staining, oil-red ocher staining and dermoscopic photographs of each sample taken seven days after acne induced by using a hairless rat model,

FIG. 21 is a photograph showing the results of immunohistochemical staining for observing the change of fatty acid synthesis protein (FAS) in the sebaceous glands after acne induced using a skinless rat model,

FIG. 22 is a photograph showing the result of immunohistochemical staining for confirming the decrease of the sebaceous proliferative marker ki-67 after acne induced using a hairless mouse model.

An acne disease treatment system including a microneedle high frequency handpiece and a light beam conditioning handpiece integrally includes a main body; A high frequency generator connected to one end of the high frequency control board and connected to the high frequency control board and a high frequency generator connected to one end of the high frequency cable connected to the high frequency control board, A microneedle high frequency treatment unit including a microneedle high frequency handpiece; And a pulsed light beam irradiation power source unit mounted on the other side of the main body and composed of a main power source case and a main power board, a pulse light irradiation cooling water circulation device, a pulse light irradiation connection cable, and a cooling water connection connected to the pulse light irradiation cooling water circulation device And a pulse light irradiation connector connected to the pulsed light irradiation connection cable, the light source being connected to the pulsed light irradiation connection cable and irradiating the pulsed light in contact with the skin, And a vacuum suction unit connected to the vacuum suction unit to generate a vacuum suction pressure, and a suction cable connected to the vacuum suction unit, wherein the microneed high frequency handpiece includes a high frequency generating unit A handle having an opening at the other end; And a needle cartridge detachably coupled to one side of the handle and having a needle inserted into the skin and transmitting a high frequency to the skin, the needle cartridge including: a holder having both sides opened and a passage formed therein; A needle assembly coupled to one side of the holder and having the needles; And a connector coupled to the other opening of the holder and connected to one side of the needle assembly and having a fitting portion on the other side.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. It should be noted that the same components are denoted by the same reference numerals as possible in the accompanying drawings. Further, the detailed description of known functions and configurations that may obscure the gist of the present invention will be omitted.

Furthermore, the terms and words used in the present specification and claims should not be construed to be limited to ordinary or dictionary terms, and the inventor should understand the concept of the term The present invention should be construed as meaning and concept consistent with the technical idea of the present invention.

1 to 4, an acne disease treatment system according to an embodiment of the present invention includes a main body B, a pulse light irradiation unit 700, and a light air pressure treatment unit And a microneedle high-frequency handpiece (R), and further includes a low-frequency stimulation handpiece (P).

The main body B includes a lower base B-1, a cover B-2 coupled to the upper portion of the lower base B-1, and a main case B- -3).

A liquid crystal screen B-4 having a touch screen is formed on one side of the cover B-2 of the main body. The liquid crystal display part is a touch screen, and various menus for controlling the pulse light irradiation and the high frequency operation are displayed. By touching various menus, on / off is controlled, and various functions are selected and used. On one side of the cover B-2, a switch unit B-22 composed of ON / OFF control and an emergency switch is formed. If an emergency occurs during use, the emergency switch is operated to stop the procedure, thereby minimizing the risk of a safety accident.

5 and 6, the microneedle high-frequency handpiece R includes a high-frequency generating unit 800 and a microneedle high-frequency handpiece R. The microneedle high-frequency handpiece R has a high- A handle 500 connected to the generating part 800 and having a cylindrical shape for holding by hand and having an opening at the other end; And a needle cartridge (3) fitted to one side of the handle (500) and provided with a needle (32) to which power is supplied and high frequency is output to the skin.

The knob 500 includes parts such as a conductor 120 and a power plug 350 for supplying power to the inside of the knob 500. The knob 500 has a cap (not shown) for coupling the coupling part 314 of the needle cartridge 3 to the front end thereof. 7) are combined. A stopper 130 inserted into the fitting slot 315 is formed on the inner peripheral surface of the cap 7.

The needle cartridge 3 can be detached and attached to the handle 500, and can be detached and used, and can be discarded after one use and replaced with a new one, which is hygienic and safety can be ensured.

The needle cartridge 3 includes a holder 31 having both open sides and a passage formed therein; A needle assembly 300 coupled to one side of the holder 31 and having a needle 32 inserted into the skin; A connector 340 coupled to the other opening of the holder 31 and connected to one side of the needle assembly 300 and having a fitting portion 342 at the other side thereof; And a power plug 350 that is detachably fitted to the fitting portion 342 of the connector 340 and is coupled to the handle 100 to supply power.

The holder 31 has a needle insertion hole 313 through which the needle assembly 300 is inserted and a coupling portion 314 through which the connector 340 is inserted.

The holder 31 is formed into a cylindrical shape by coupling the two divided first and second bodies 311 and 312 to face each other and further from the front end where the needle insertion hole 313 is formed to the rear end where the coupling portion 314 is formed The tapered shape is formed so as to have a larger diameter, so that the shape is easily grasped by the thumb and the index finger.

The engaging portion 314 is formed in a cylindrical shape at the rear end of the holder 31 and has a diameter smaller than that of the rear end of the holder 31. The engaging portion 315 is recessed concavely in an outer surface of the holder 31, And is engaged with the fastening portion 510 of the handle 500 to be engaged.

A stopper 130 inserted into the fitting slot 315 is formed on an inner circumferential surface of the cap 7.

A space is formed inside the first and second bodies 311 and 312, and a guide step 38 is formed on the cut surface at the edge of the space.

The guide step 38 is a part where the outer periphery of the needle assembly 300 to be described later is in close contact with the needle assembly 300. The needle assembly 300 can be stably fixed by closely contacting the guide assembly 38 with the guide step 38 .

The needle assembly 300 is a thin metal plate having conductivity. A through hole 29 is formed at one side coupled to the connector 340 and a needle 32 is formed at the other end.

The needle assembly 300 is formed so as to have a width from 1 to 2 steps from the opposing portion of the needle 32 and is divided into a first step 301, a second step 302 and a third step 303 .

The first to third steps 301 to 303 are shaped to fit the guide step 38 of the holder 31.

A through hole 305 is formed in one side of the needle assembly 300 through a holder 31 and through which an engaging shaft 223 penetrating through the connector 340 is inserted and a pin formed on the holder 31 is fitted to the other side A fixing hole 307 is formed. Therefore, after the needle assembly 300 is coupled to the holder 31 and the connector 340 is engaged, the needle assembly 300 can be securely fixed so as not to shake.

The needle 32 is made of a conductive material so that it can be transmitted to the skin by applying a high-frequency signal to the needle 32 from the outside.

The needles 32 may be formed as one, or a plurality of the needles 32 may be formed.

The connector 340 is a conductive rod having a conductive shape. The outer surface of the connector 340 is vertically cut to form a mounting surface 341, and a plurality of cut-outs are arranged in the circumferential direction to form a cylindrical shape, 342 are formed.

The needle assembly 300 is closely attached to the mounting surface 341 of the connector 340. A screw may be inserted through the mounting surface 341 and a part of the screw may be coupled to the needle assembly 300 to be integrated.

One end of the power plug 350 is coupled to the fitting portion 342 of the connector 340 and the other end of the power plug 350 is connected to the conductor 120 by fitting.

In the middle of the power plug 350, the outer diameter is enlarged to form the enlarged portion 352, and a part of the enlarged portion 352 is formed flat to form the groove portion 353. The groove 353 is inserted into the conductor 120 to serve as a latching jaw, thereby preventing the power plug 350 from being unintentionally lifted off.

The low frequency stimulation handpiece P includes a cable 620 connected to the main body B, a handle 640 connected to the cable 620, and a low frequency stimulation electrode 610 formed at the end of the handle 640, And a probe 660 for transmitting the probe 660 to the skin.

The probe 660 is formed of a conductive metal, and is formed with a plurality of low frequency stimuli applied to the skin to help stabilize the skin after the pulsed light irradiation and to regenerate the tissue.

The optical air pressure treatment unit is composed of a pulsed light irradiation unit 700 and a light-guiding handpiece L. [ The pulsed light irradiation unit 700 includes a main power source case 721 mounted on the main case B-3 and a main power board 722 incorporated in the main power source case 721. [ A pulsed light irradiation irradiation cooling water circulation device 740 mounted on the main case B-3, a pulsed light irradiation connection cable 762 attached to the main case B-3, (Not shown) connected to the used handpiece L to generate a vacuum suction pressure, a suction cable 764 connected to the vacuum suction unit, and a cooling water circulating device 740 connected to the pulsed light irradiation water circulating device 740 And a pulsed light irradiation connector 760 to which the connection cable is coupled.

The main power board 722 provided in the pulsed light irradiation power source unit 720 is coupled to the main power source case 721 and power is applied thereto.

The pulse light irradiation water circulation device 740 includes a water tank 742 in which cooling water is stored; A water pump 744 for transferring the cooling water of the water tank 742; A cooling water supply pipe (746) connected to the discharge side of the water pump (744) and connected to the light beam manipulating handpiece (L); And a cooling water cooler 748 for cooling the heated cooling water discharged from the light-guiding handpiece (L). The cooling water supply pipe 746 includes a flow rate sensor (not shown) for sensing the flow of the cooling water and checking the temperature and the flow rate.

The cooling water cooler 748 includes a cooling coil pipe arranged in a zigzag shape and connected to a cooling water supply pipe 746 and a cooling fan formed at one side of the cooling coil pipe for discharging air to cool the cooling coil pipe.

The vacuum suction unit includes an air filter connected to a suction cable of the light-guiding handpiece (L); A vacuum motor connected to the suction cable and generating a vacuum suction force; A pressure sensor formed on the suction cable; And a solenoid valve interposed in the suction cable and interlocked with the pressure sensor.

A vacuum suction force is generated in the light-guiding handpiece L by the operation of the vacuum motor, and the foreign substance generated during the procedure is sucked and removed.

A high frequency generator 800 configured by a high frequency control board 820 mounted on the other side of the main case B-3 and a high frequency power 840 connected to the high frequency control board 820; And a microneedle high frequency handpiece (R) connected to one end of a high frequency cable connected to the high frequency control board (820) and brought into contact with the skin for high frequency treatment.

As shown in FIGS. 7 to 9, the light-guiding handpiece L irradiates the skin with a pulsed light beam. The light-guiding handpiece L includes a handle 100 having a head 120 on one side and a pipe on the other side ); A pulsed light irradiation lamp 24 formed in the body 22 and a pulsed light irradiation lamp 24 housed in the body 120. The pulsed light irradiation lamp 24 is accommodated in the body 22, And a pulse light irradiation module 2 composed of a glass pipe 26 embedded therein.

A suction plate 42 coupled to a lower portion of the body 22 and a reflector 44 coupled to the suction plate 42 and a suction rubber 46 surrounding the reflector 44, A sucking part 4 constituted by a suction hose 45 and a suction hose 45 which are coupled through the suction rubber 46 and the reflector 44 so as to communicate with the suction plate 42; .

In the suction rubber 46, the opening portion of the lower portion is brought into close contact with the skin portion of the skin to block the inflow of outside air when the suction operation is performed. As a result, negative pressure is generated and the skin tissue is sucked to contract the blood vessels and remove the acne have. It also affects deep sebaceous skin with powerful sound pressure, which increases the destruction rate of acne causing bacteria. In addition, the skin, blood, sebum, etc. sucked and extracted from the affected part of the skin can be introduced into the suction hose 45. This makes it possible to create an environment suitable for acne treatment for pulsed light irradiation. Then, pulsed light can be irradiated to the skin tissue of the area where acne is generated and the residue drawn out of the skin through the vacuum suction force.

The body 22 of the pulse light irradiation module 2 is made of aluminum having a high thermal conductivity and is formed into a square box shape.

The body 22 is open at both sides, a space is formed therein, and an opening is formed at a lower portion. And a pulse light irradiation filter 43 is coupled to the opening.

The first and second brackets 221 and 222 having the annular grooves 220 are coupled to the front and rear surfaces of the body 22 so that both ends of the pulsed light irradiation lamp 24 and the glass tube 26 are coupled.

The first and second brackets 221 and 222 are formed in a square shape to correspond to the sectional area size of the body 22, and the annular groove 220 is formed in the center of the interior.

The lamp guide 224 is coupled to the outside of the first and second brackets 221 and 222 and has a slot 225 through which the end of the pulsed light irradiation lamp 24 is inserted.

The pulsed light ray irradiation lamps 24 are arranged in a triangle shape and housed in the body 22. Both ends of the pulsed light ray irradiation lamps 24 are inserted into the slots 225 of the lamp guide 224 so that power is supplied thereto for light irradiation .

A suction nipple 422 is formed on one side wall of the suction plate 42. A suction hose 45 is connected to the suction nipple 422 and a suction hose 45, a vacuum suction force is generated from a vacuum pressure generating unit (not shown) so that a suction force is formed inside the suction plate 42.

The reflector 44 may have a rectangular shape having a width equal to the width of the upper portion and a width smaller than that of the lower portion. The reflector 44 may be coupled to the suction plate 42, Thereby refracting the light beam.

A cooling unit 6 coupled to the head unit 120 and cooling the pulsed light irradiation module 2 is also included. The cooling section 6 includes a cooling element 62 adhered to the upper portion of the body 22, a cooling jacket 64 seated on the upper surface of the cooling element 62, A cooling water inlet pipe 65 and a cooling water outlet pipe 66 which are connected to each other. A temperature sensor 5 is coupled to one side of the cooling jacket 64 and inserted therein to measure the temperature of the cooling water. The body 22 is cooled by the cooling heat of the cooling element 62 adhered to the body 22 because the skin may be burned if the pulse light irradiation module 2 is overheated. Since the body 22 is made of an aluminum material, its thermal conductivity is high and its cooling rate is high, it is always effective to maintain an appropriate temperature. As the body 22 is cooled, overheating of the pulsed light irradiation lamp 24 housed therein can be prevented, so that the life of the pulsed light irradiation lamp 24 can be extended, and excessive heat can be prevented from being applied to the skin.

A method for operating an acne disease treatment system comprising a main body, a microneedle high frequency treatment unit, and an optical pneumatic treatment unit integrally according to the present invention is characterized by comprising: a high frequency control board mounted on one side of the main body; A high frequency generating unit comprising: And a handle connected to one end of a high-frequency cable connected to the high-frequency control board and contacting the skin to perform a high-frequency treatment, the one end of the handle being connected to the high- And a microneedle high frequency handpiece detachably coupled to one side of the knob and having a needle inserted into the skin and adapted to transmit a high frequency to the skin, Contacting the microneedle high frequency handpiece to the skin to be treated and applying a high frequency voltage to the high frequency generator; And a pulsed light beam irradiation power source unit mounted on the other side of the main body and composed of a main power source case and a main power board, a pulse light irradiation cooling water circulation device, a pulse light irradiation connection cable, and a cooling water connection connected to the pulse light irradiation cooling water circulation device And a pulse light irradiation connector connected to the pulsed light irradiation connection cable, the light source being connected to the pulsed light irradiation connection cable and irradiating the pulsed light in contact with the skin, And a vacuum suction unit connected to the vacuum suction unit to generate a vacuum suction pressure, and a suction cable connected to the vacuum suction unit, wherein after the operation of the microneedle high frequency handpiece is completed, , And the pulse light irradiation unit Applying a beam projector voltage; including works acne diseases system.

The acne disease treatment system of the present invention further comprises a low frequency stimulation handpiece formed of a cable connected to the main body, a handle connected to the cable, and a probe formed at an end of the handle and transmitting a low frequency stimulus to the skin Contacting the microneedle high frequency handpiece with a skin to be treated by a practitioner using the microneedle RF treatment unit and applying a high frequency voltage to the high frequency generating unit; Contacting the light beam manipulating handpiece to the high frequency irradiated portion after application of the microneedle high frequency handpiece is completed using the optical air pressure treatment unit and applying a pulse light irradiation voltage to the pulse light irradiation unit; And operating a probe for transmitting a low-frequency stimulus to the skin to the treatment site with the low-frequency stimulation handpiece after the operation of the light-guiding handpiece is completed by applying the pulse light irradiation voltage.

In order to test the acne treatment performance of the acne disease treatment system according to the present invention, the skin stability was evaluated using the skin of the rats, and the result of checking the skin irritation or damage after the RF and pulse irradiation treatment was shown in Fig. . As shown in Fig. 11, irreversible skin irritation or damage was not observed in the treatment with RF and pulsed light irradiation. Fig. 11 (a) is a needle 1.2 mm, and [b] a needle 1.5 mm. As a result of RF and pulsed light irradiation, skin stability of both RF and pulsed light irradiation treatment was confirmed.

On the other hand, FIG. 12 shows the results of confirming the efficacy of the combination treatment of RF and the pulsed light irradiation on the acne strain.

12, the state of the acne strain in the untreated group is [a], the state of the acne strain in the group of one pulse light irradiation process (5 levels, duration 1000 ms, shot 3 times) is [b] After the treatment (10 levels of energy, 1000ms, 3 times), the condition of the acne strain in one group is [c]. In comparison with acne strain status of group [a], which has not been treated, acne strain destruction effect is shown in both test group [b] treated with pulsed light irradiation alone and test group [c] And acupuncture strain disruption was clearly observed in the pulsed light irradiation combination test group [c]. In other words, it can be seen that the treatment with RF and pulse light irradiation is effective for treating acne.

Using a rabbit ear acne model, P. acnes was inoculated and acne was induced. At 1, 3, 5, and 7 days after induction, pulsed light irradiation alone, RF and pulsed light irradiation. We also used DSLR and dermascope ( ^TM ) to evaluate the improved acne scar and pore status after the procedure, and use the AnTERA 3D ^TM equipment Safety and acne treatment efficacy were evaluated.

Experimental conditions were classified into single pulsed light irradiation treatment and RF and pulse light irradiation combined treatment. On the other hand, the needle gauge used in RF and pulsed light irradiation procedures is 1.2 mm and 1.5 mm.

Experimental group	Experimental conditions
	Classification		Device treatment condition
G1	P. acnes inoculation	Untreated group	X
G2	P. acnes inoculation	Positive control group [continued application of oleic acid]	X
G3		Pulsed light irradiation alone treatment	Pulsed light irradiation: 3 pulse, 5 level, duration 1000 ms
G4		RF and pulsed light irradiation combination treatment	RF: 5 level, 400 ms Pulse beam irradiation: 3 pulse, 5 level, duration 1000 ms

As shown in the above table, acne strain was inoculated into four groups of rabbit ear acne induced model, and the efficacy of RF and pulse irradiation treatment for acne strains was evaluated. The height of the acne, the height of the acne, the height of the acne, the height of the acne, the volume of elevations of the acne, the elevations-affecetd area value of the acne, the elevations-maximum height value, the average roughness value (Ra) (root mean squared surface roughness, Rq).

13, which shows the volume of elevations, it can be seen that the degree of ridging of acne is greatly improved when the acne treatment system of the present invention is used together with RF and pulsed light irradiation. 14 shows the elevations-affecetd area value of acne. When the acne disease treatment system according to the present invention is used for treatment with RF and pulsed light irradiation, The acne was improved when the acne treatment treatment system of the present invention was used for RF and pulsed light irradiation together with the area of the acupuncture maximum height value shown in Fig. , The roughness of the surface is further relaxed by observing the average roughness value (Ra) of FIG. 16, when treated with RF and pulsed light irradiation using the acne disease treatment system of the present invention, . The root mean squared surface roughness (Rq) of FIG. 17 was also higher than that of the single treatment of pulsed light irradiation, and the roughness of the surface when treated with RF and pulsed light irradiation treatment using the acne disease treatment system of the present invention It can be seen that it is more relaxed. As can be seen from these observations, it can be seen that when acupuncture treatment system of the present invention was used in combination with RF and pulsed light irradiation, the acne index was alleviated compared to the pulsed light irradiation alone group.

18 and 19 show the results of immunohistochemistry to confirm the reduction of inflammatory factors in the above four groups.

FIG. 18 is a graph showing the effect of the PPAR Gamma (Peroxisome proliferator) gene, which is a gene transcription factor promoting the synthesis of an anti-inflammatory mediator, in the treatment group treated with RF and pulsed light irradiation using the acne disease treatment system of the present invention, -activated receptor gamma, PPAR gamma).

FIG. 19 is a graph showing the relationship between tumor necrosis factor alpha, TNF-alpha and TNF in the treatment group treated with RF and pulsed light irradiation using the acne disease treatment system of the present invention, Was confirmed. Therefore, it can be understood that the inflammatory factor was decreased when the combination of RF and pulsed light irradiation was performed using the acne disease treatment system of the present invention as compared to the pulsed light irradiation alone group.

As a result of evaluating skin stability and efficacy using a hairless rat model, compared with pulsed light irradiation alone group, when the acne treatment system of the present invention was used in combination with RF and pulsed light irradiation, fatty acid synthesis in the sebaceous glands A decrease in protein (FAS) and sebaceous hyperplasia marker (ki-67) was observed. As in the rabbit ear acne induction in the unarmed rats, the appearance of the acne strain was observed immediately after 1 day, 4 days, and 7 days after the inoculation.

Experimental conditions were classified into single pulse treatment (divided into low and high) and RF and pulse irradiation treatment. On the other hand, the needle gauge used in the RF and pulsed light irradiation procedure is 1.2 mm.

Experimental group	Experimental conditions
	Classification		Device treatment condition
G-1	P. acnes inoculation	Untreated group	X
G-2	P. acnes inoculation	Pulsed light irradiation single treatment (low)	Pulsed light irradiation: 3 pulse, 5 level, duration 1000 ms
G-3		Pulsed light irradiation single treatment (high)	Pulsed light irradiation: 3 pulse, 9 level, duration 1000 ms
G-4		RF and pulsed light irradiation combination treatment	RF: 5 level, 400 ms Pulse beam irradiation: 3 pulse, 5 level, duration 1000 ms

20 shows the results of visual acuity observation, hematoxylin and eosin staining followed by dermoscopy and Solvent Red 27, Sudan Red, and the like, after acne strain was inoculated on unarmed rats and after 7 days, 5B, CI 26125, C ₂₆ H ₂₄ N ₄ O, Oil Red O).

While the sebaceous glands were clearly observed in the untreated group (G-1), a change in the sebaceous gland was observed in the pulsed light irradiation single treatment group (G-2 and G-3) 4), the sebaceous gland destruction effect was remarkably observed compared to the pulsed light irradiation alone treatment group.

FIG. 21 shows the result of immunohistochemistry to confirm the decrease of FAS in the sebaceous glands of the four groups, and FIG. 21 shows the results of the immunohistochemical staining of the sebaceous proliferation marker ki-67 The results of immunohistochemical staining for confirming the reduction were shown in Fig. 21 and 22, compared with the pulsed-light irradiation alone treatment group (G-2 and G-3), the treatment group for treating acne disease according to the present invention and RF (FAS) and sebaceous hyperplasia marker (ki-67) in the sebaceous glands.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It will be understood. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

The present invention is applicable to an acne disease treatment system and an operation method thereof for treating moderate to severe acne in an adult.

Claims (16)

1. It is an acne disease treatment system that includes a microneedle high frequency handpiece and a light-guided handpiece.

   main body;

   A high frequency generator connected to one end of the high frequency control board and connected to the high frequency control board and a high frequency generator connected to one end of the high frequency cable connected to the high frequency control board, A microneedle high frequency treatment unit including a microneedle high frequency handpiece; And

   A pulsed light irradiation power source unit which is mounted on the other side of the main body and is composed of a main power source case and a main power board, a pulse light irradiation cooling water circulation device, a pulse light irradiation connection cable, a cooling water connection cable A pulse light irradiation unit connected to the pulsed light irradiation connection cable and contacting the skin and irradiating a pulsed light beam, and a light source unit connected to the light source unit And an optical air pressure treatment unit including a vacuum suction unit for generating a vacuum suction pressure and a suction cable connected to the vacuum suction unit,

   The microneedle high frequency handpiece

   One end connected to the high frequency generator and the other end having an opening;

   And a needle cartridge detachably coupled to one side of the handle and having a needle inserted into the skin and transmitting a high frequency to the skin,

   Wherein the needle cartridge comprises:

   A holder having both sides opened and a passage formed therein;

   A needle assembly coupled to one side of the holder and having the needles;

   And a connector coupled to the other opening of the holder and connected to one side of the needle assembly and having a fitting portion on the other side.
2. The method according to claim 1,

   A low frequency stimulation handpiece comprising a cable connected to the main body, a handle connected to the cable, and a probe formed at an end of the handle and transmitting a low frequency stimulus to the skin.
3. The method according to claim 1,

   The pulsed light irradiation cooling water circulation device

   A water tank in which cooling water is stored;

   A water pump for transferring the cooling water of the water tank;

   A cooling water supply pipe connected to the discharge side of the water pump and connected to the light beam manipulating handpiece;

   A cooling water cooler for cooling the heated cooling water discharged from the light-guiding handpiece; And

   Wherein the cooling water supply pipe is formed with a flow rate sensor for sensing the flow of cooling water and checking temperature and flow rate.
4. The method of claim 3,

   The cooling water cooler

   A cooling coil pipe connected to the cooling water supply pipe and arranged in a zigzag shape,

   And a cooling fan formed on one side of the cooling coil pipe to cool and cool the air.
5. The method according to claim 1,

   The vacuum suction unit

   An air filter connected to the suction cable of the light-guided handpiece;

   A vacuum motor connected to the suction cable to generate a vacuum suction force;

   A pressure sensor formed on the suction cable;

   A solenoid valve formed in the suction cable and interlocked with the pressure sensor to intermittently switch on and off;

   Wherein the acne disease treatment system comprises:
6. The method according to claim 1,

   The handle

   The cap is coupled to one side so that the engaging portion of the needle cartridge is engaged,

   And a stopper is formed on an inner peripheral surface of the cap.
7. The method according to claim 1,

   The holder

   A needle insertion hole for inserting a needle knife is formed at one side, and a coupling portion having a through hole for inserting a connector is formed at the other side,

   Wherein the engaging portion is formed in an outer circumferential surface with a fitting slot having an " a " shape and is coupled to the handle.
8. The method according to claim 1,

   The connector

   And a plurality of cut-out portions arranged at one end in a circumferential direction to form the fitting portion,

   And a mounting surface is formed on the other outer circumferential surface so that the needle is closely contacted.
9. The method according to claim 1,

   The needle acupuncture treatment system according to claim 1, wherein the needle assembly is a conductive metal plate, and one or more needles are formed on one side of the needle assembly and the needle on the other end of the needle assembly.
10. The method according to claim 1,

    The light-guiding handpiece

    A handle having a head formed on one side and a pipe formed on the other side;

    A pulsed light irradiation module including a body embedded in the head and having an opened lower portion, a pulsed light irradiation lamp formed in the body, and a glass pipe accommodated in the pulsed light irradiation lamp and embedded in the body;

    A suction hose coupled to the lower portion of the body and connected to the suction plate through a reflector, a reflector coupled to the suction plate, a suction rubber surrounding the reflector, A suction part composed of a suction hose and exhibiting a suction force;

    Wherein the acne disease treatment system comprises:
11. 11. The method of claim 10,

    A cooling element connected to the head portion and closely attached to an upper portion of the body; a cooling jacket seated on an upper surface of the cooling element; a cooling water inlet pipe connected to the cooling jacket to communicate with the cooling jacket; ;

    Wherein the acne disease treatment system comprises:
12. A method for operating an acne disease treatment system comprising a main body, a microneedle high frequency treatment part, and an optical air pressure treatment part integrally,

    A high frequency generator mounted on one side of the main body, the high frequency generator comprising a high frequency control board and a high frequency power connected to the high frequency control board; And

    A handle connected to one end of a high-frequency cable connected to the high-frequency control board, the handle being in contact with the skin to perform a high-frequency treatment, the one end being connected to the high- A microneedle high frequency handpiece detachably coupled to one side of the handle and including a needle cartridge inserted into the skin and adapted to transmit a high frequency to the skin,

    Wherein the needle cartridge comprises:

    A holder having both sides opened and a passage formed therein;

    A needle assembly coupled to one side of the holder and having the needles;

    And a connector coupled to the other opening of the holder, the connector being connected to one side of the needle assembly and the other side having a fitting portion,

    Contacting the microneedle high frequency handpiece with a skin to be treated by a practitioner and applying a high frequency voltage to the high frequency generator; And

    A pulsed light irradiation power source unit which is mounted on the other side of the main body and is composed of a main power source case and a main power board, a pulse light irradiation cooling water circulation device, a pulse light irradiation connection cable, a cooling water connection cable A pulse light irradiation unit connected to the pulsed light irradiation connection cable and contacting the skin and irradiating a pulsed light beam, and a light source unit connected to the light source unit A vacuum suction unit for generating a vacuum suction pressure, and a suction cable connected to the vacuum suction unit,

    And a step of contacting the light beam manipulating handpiece to the high frequency irradiated part after application of the microneedle high frequency handpiece is completed and applying a pulsed light irradiation voltage to the pulse light irradiation generating part How it works.
13. 13. The method of claim 12,

    In the step of contacting the microneedle high-frequency handpiece with the skin to be treated by a practitioner and applying a high-frequency voltage to the high-

    The handle

    The cap is coupled to one side so that the engaging portion of the needle cartridge is engaged,

    A stopper is formed on the inner circumferential surface of the cap,

    Wherein the holder comprises:

    A needle insertion hole for inserting a needle knife is formed at one side, and a coupling portion having a through hole for inserting a connector is formed at the other side,

    Wherein the engaging portion is formed in an outer circumferential surface with a " b " -shaped fitting slot and is coupled to the handle.
14. 13. The method of claim 12,

    In the step of contacting the light beam adjusting handpiece to the high frequency irradiated portion and applying the pulse light irradiation voltage to the pulse light beam generating portion,

    The light-guiding handpiece

    A handle having a head formed on one side and a pipe formed on the other side;

    A pulsed light irradiation module including a body embedded in the head and having an opened lower portion, a pulsed light irradiation lamp formed in the body, and a glass pipe accommodated in the pulsed light irradiation lamp and embedded in the body;

    A suction hose coupled to the lower portion of the body and connected to the suction plate through a reflector, a reflector coupled to the suction plate, a suction rubber surrounding the reflector, A suction part composed of a suction hose and exhibiting a suction force;

    A cooling element connected to the head portion and closely attached to an upper portion of the body; a cooling jacket seated on an upper surface of the cooling element; a cooling water inlet pipe connected to the cooling jacket to communicate with the cooling jacket; ≪ / RTI >;
15. 13. The method of claim 12,

    In the step of contacting the light beam adjusting handpiece to the high frequency irradiated portion and applying the pulse light irradiation voltage to the pulse light beam generating portion,

    The pulsed light irradiation cooling water circulation device

    A water tank in which cooling water is stored;

    A water pump for transferring the cooling water of the water tank;

    A cooling water supply pipe connected to the discharge side of the water pump and connected to the light beam manipulating handpiece;

    A cooling water cooler for cooling the heated cooling water discharged from the light-guiding handpiece;

    Wherein the cooling water supply pipe includes a flow rate sensor for sensing the flow of the cooling water and checking the temperature and the flow rate,

    The cooling water cooler

    A cooling coil pipe connected to the cooling water supply pipe and arranged in a zigzag shape,

    And a cooling fan which is formed at one side of the cooling coil pipe and ejects air to cool the cooling coil,

    The vacuum suction unit

    An air filter connected to the suction cable of the light-guided handpiece;

    A vacuum motor connected to the suction cable to generate a vacuum suction force;

    A pressure sensor formed on the suction cable;

    And a solenoid valve formed on the suction cable and interlocked with the pressure sensor to cut off the on-off state.
16. The method according to any one of claims 12 to 15,

    The acne disease treatment system comprises:

    A low frequency stimulation handpiece formed of a cable connected to the main body, a handle connected to the cable, and a probe formed at an end of the handle and transmitting a low frequency stimulus to the skin,

    Using the microneedle RF treatment unit,

    Contacting the microneedle high frequency handpiece with a skin to be treated by a practitioner and applying a high frequency voltage to the high frequency generator;

    Using the optical air pressure treatment unit,

    After the operation of the microneedle high frequency handpiece is completed, bringing the light beam manipulating handpiece into contact with the high frequency irradiated part and applying a pulse light irradiation voltage to the pulsed light ray generating part; And

    And operating a probe for delivering a low-frequency stimulus to the skin to the treatment area with the low-frequency stimulation handpiece after the operation of the light-guiding handpiece is completed by applying the pulse light irradiation voltage.

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