WO2019146825A1 - Composition pour la prévention ou le traitement d'infections parasitaires chez les poissons, comprenant un extrait d'artichaut de jérusalem ou une fraction de celui-ci - Google Patents

Composition pour la prévention ou le traitement d'infections parasitaires chez les poissons, comprenant un extrait d'artichaut de jérusalem ou une fraction de celui-ci Download PDF

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Publication number
WO2019146825A1
WO2019146825A1 PCT/KR2018/001248 KR2018001248W WO2019146825A1 WO 2019146825 A1 WO2019146825 A1 WO 2019146825A1 KR 2018001248 W KR2018001248 W KR 2018001248W WO 2019146825 A1 WO2019146825 A1 WO 2019146825A1
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WIPO (PCT)
Prior art keywords
fish
extract
potato
preventing
fraction
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PCT/KR2018/001248
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English (en)
Korean (ko)
Inventor
이태훈
최원식
정태성
손세진
김태규
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전진바이오팜 주식회사
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Priority to PCT/KR2018/001248 priority Critical patent/WO2019146825A1/fr
Publication of WO2019146825A1 publication Critical patent/WO2019146825A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Definitions

  • the present invention relates to a composition for preventing or treating a parasitic infectious disease of fish comprising an extract of Jerusalem artichoke as an active ingredient, and more particularly to a composition for preventing or treating a parasitic infectious disease of fish, and more particularly to a composition comprising a potato extract,
  • salmon aquaculture is an alternative to depletion of fishery resources and is mainly focused on fish species with excellent commercial characteristics.
  • salmon contains many unsaturated fatty acids such as DHA and EPA, The world's largest fish species, the world's largest salmon aquaculture country is Norway, followed by England, Chile, Canada and Australia.
  • the common feature of salmon cultivation stations is that they are located in the waters where cold seawater flows.
  • the global salmon market is estimated at 4.3 million tons and 20 trillion won a year, including around 60 trillion won if it includes the processing market.
  • Cherry salmon is a salmon inhabited by rivers and oceans of Korea, China, Japan and Russia. Its size is 60 cm smaller than 1 meter of Norwegian salmon. We call it Shima salmon which is Japanese name. In other words, in Korea, salmon and trout form, but they do not use the name salmon but chuck salmon (trout). Trout fishing and festivals in winter are famous. In Korea, the development of freshwater-based inland water trout farming has developed, and in 2015 it was the 50th anniversary of trout farming. Meanwhile, salmon can be classified into Pacific salmon and Atlantic salmon. In Korea, silver salmon belonging to Pacific salmon is being tried. On the other hand, Atlantic salmon is being cultivated in large scale in North Sea fjord such as Norway, and it is cultivated in Chile and Canada in the Pacific coast. Korea is still under trial research.
  • Patent Document 1 KR1020010109335 A
  • the present invention provides a composition for preventing or treating an infectious disease caused by a fish parasite including a sea lice in an environmentally friendly manner without causing resistance, toxicity and environmental pollution by using a potato as a food material harmless to human body .
  • the present invention provides a pharmaceutical composition for preventing or treating a fish parasitic infectious disease comprising an extract of Piglet (Jerusalem artichoke) or a fraction thereof as an active ingredient.
  • the pig potato extract is a leaf, stem, root, fruit or outpast of a potato, and is selected from the group consisting of Inuline, Betaine, Lutein, Helenien, hemagglutinin, It contains saponin.
  • the porcine potato extract according to the present invention can be obtained by ultrasonic extraction, hot water extraction or solvent extraction, but is not limited thereto.
  • the fish parasite is selected from the group consisting of sea lice, Cymothoa Exigua, Ichthyophthirius multifiliis, Bivagina tai, Anisakiasis, Distoma, Scutica, Benedenia or Anisakis Simplex, preferably in the genus Lepeophtheirus, or in the caligus, in the caligidae, More preferred are sea lice, Lepeoptheirus salmonis or caligus rogercresseyi.
  • fish can be collectively referred to as any fish to which the parasitic infectious disease according to the present invention can develop without limitation, and preferably salmon, trout, catfish, perch, tuna, halibut, arctic fish, sturgeon, It includes a lot of fish, sandfish, tiger prawn, carp, tilapia, rower, eel, sea bream, yellow tail, amber jacquard, jambar, rockfish, red sea bream, red sea bream, flounder, mackerel, . It is also preferably, but not exclusively, aquaculture. It is preferably Salmonidae.
  • the present invention also provides a feed additive composition for preventing or ameliorating a fish parasitic infection comprising a Jerusalem artichoke extract or a fraction thereof as an active ingredient.
  • the present invention also provides a composition for controlling or insecting a fish parasite, comprising an extract of Piglet (Jerusalem artichoke) or a fraction thereof as an active ingredient.
  • the present invention provides a method for preventing or treating parasitic infestation of a fish by injecting a composition comprising an extract of Piglets (Jerusalem artichoke) or a fraction thereof as an active ingredient into a fish.
  • a composition comprising an extract of Piglets (Jerusalem artichoke) or a fraction thereof as an active ingredient into a fish.
  • composition comprising the potato extract of the present invention or the fraction thereof as an active ingredient can be used as a preventive or therapeutic agent for fish parasites because it induces sea lice to be avoided or to inhibit or eliminate the approach of parasites when consumed by fish have.
  • Figure 1 shows a Y-tube chamber for sea lice avoidance experiments.
  • Fig. 2 shows the results of the seaweed avoidance effect of potato extract.
  • Figs. 3 (a) and 3 (b) show the death, drowning and survival rate of sea lice in a concentration-dependent manner.
  • Jerusalem artichoke is also known as ground potato, sorghum, mackerel, mung bean, mulberry, potato, kukwoo and mackerel. It has excellent effect on prevention of diabetes treatment and complication in root, Or more.
  • porcine potato may be used as a living organism, or may be a dried potato using a drying method such as natural drying, oven drying, hot air drying or freeze drying, or a pork potato having undergone more than one process through a method such as juicing, grinding, Can
  • extract in the present invention means an extract obtained by extracting the pig potatoes, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a controlled preparation or a purified product of the extracted solution, Itself and extracts of all formulations which can be formed using extracts.
  • the method for extracting the porcine potato is not particularly limited, and may be extracted according to a method commonly used in the art.
  • Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.
  • the kind of the extraction solvent used for extracting the porcine potato is not particularly limited, and any solvent known in the art can be used.
  • Non-limiting examples of the extraction solvent include water; C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof.
  • Water, a lower alcohol, 1,3-butyleneglycol, and ethyl acetate may be used alone or in admixture of two or more.
  • the extract may be extracted with a solvent selected from the group consisting of water, an alcohol having 1 to 4 carbon atoms and a mixed solvent thereof, and the alcohol may be methanol, ethanol, propyl alcohol or butanol, But is not limited to.
  • the potatoes are dried naturally at room temperature for 5 to 7 days after harvesting, and pulverized to about 1 to 20 times, preferably about 1 to 5 times (C1) to 4 (C4) lower alcohols such as methanol, ethanol and butanol, or a mixed solvent having a mixing ratio of about 1: 0.1 to 1:10 thereof, as an elution solvent Extraction is carried out at a temperature of 20 to 100 ° C, preferably at room temperature, for an extraction period of about 12 to 6 days, preferably 5 days, such as hot water extraction, cold extraction, reflux cooling extraction or ultrasonic extraction .
  • C1 to 5 times C1 to 4 (C4) lower alcohols
  • C1 to 4 (C4) lower alcohols such as methanol, ethanol and butanol
  • a mixed solvent having a mixing ratio of about 1: 0.1 to 1:10 thereof as an elution solvent Extraction is carried out at a temperature of 20 to 100 ° C, preferably at room temperature, for an extraction period of about 12 to 6 days, preferably 5
  • fraction in the present invention means a product obtained by performing fractionation to separate a specific component or a specific component group from a mixture containing various components.
  • the fractionation method for obtaining the fraction in the present invention is not particularly limited and may be carried out according to a method commonly used in the art.
  • a method of treating a predetermined solvent with an extract obtained by extracting potatoes to obtain a fraction from the extract there can be mentioned a method of treating a predetermined solvent with an extract obtained by extracting potatoes to obtain a fraction from the extract.
  • the compounds contained in the potato extract include Inuline, Betaine, Lutein, Helenien, hemagglutinin and saponin. Such compounds may be obtained from the extract or fraction by conventional separation and purification processes.
  • the fish may be any fish which can cause parasitic infectious diseases according to the present invention without limitation, and preferably includes salmon, trout, catfish, perch, tuna, halibut, arctic fish, sturgeon, Includes prawns, staves, westerns, carp, tilapia, lobsters, eels, sea bream, yellow tail, amberjack, jambari, rockfish, red sea bream, red sea bream, flounder, mackerel, can do. It is also preferably, but not exclusively, aquaculture. In one embodiment of the present invention, an experiment was conducted using a representative salmon
  • the parasite of the present invention collectively refers to an invertebrate living in parasitic life outside and in the body of another organism (fish, crustacean, animal, plant, etc.).
  • the potato extract of the present invention has an effect of exterminating sea lice (FIGS. 2 and 3). Therefore, it is possible to prevent or improve the parasite infection of fishes including the potato extract of the present invention And is suitable for therapeutic use.
  • the term “prevent” means any action that inhibits or slows the onset of parasitic infectious disease of fish by the composition
  • treatment means that the composition of the fish, Means any action that is changed.
  • composition in the present invention means a preparation for the purpose of prevention or treatment of disease, and may be formulated into various forms according to ordinary methods.
  • oral formulations such as powders, granules, tablets, capsules, suspensions, emulsions and syrups, and can be formulated in the form of external preparations, suppositories, and sterilized injection solutions.
  • the composition of the present invention is provided in the form of a bathing agent for the purpose of treating diseases of fishes.
  • each of the formulations may be further prepared by incorporating pharmaceutically acceptable carriers such as buffers, preserving agents, wetting agents, solubilizing agents, isotonic agents, stabilizers, bases, excipients, lubricants and the like in the art .
  • pharmaceutically acceptable carriers such as buffers, preserving agents, wetting agents, solubilizing agents, isotonic agents, stabilizers, bases, excipients, lubricants and the like in the art .
  • the pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount.
  • pharmaceutically effective amount of the present invention means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to veterinary treatment and not causing side effects, , The severity, the activity of the drug, the sensitivity to the drug, the method of administration, the time of administration, the route of administration and the rate of release, the duration of the treatment, the factors including the combined or concurrently used drugs, and other factors well known in the veterinary arts.
  • the present invention provides a feed additive composition for preventing or ameliorating a parasitic infestation disease of fish, comprising a potato extract, a fraction thereof, or a compound isolated therefrom as an active ingredient.
  • pig potato extract, its fractions, or compounds isolated therefrom can be added to the feed composition as a feed additive, as it can be used for the purpose of preventing or ameliorating the parasitic infestation of fish .
  • the feed additive is collectively referred to as a substance added to the feed in a nutritive or special manner for a specific purpose.
  • it means a substance added for the purpose of preventing or improving a parasitic infectious disease of a fish.
  • the potato extract of the present invention or the compound isolated therefrom may be included in the feed composition as the feed additive, and the feed may be used to collectively mean all the foods supplied to the fish.
  • the feed composition of the present invention may further contain a binder, an emulsifying agent, a preservative, and the like added to prevent quality deterioration.
  • the feed composition may contain an amino acid, a vitamin, an enzyme, a probiotics, a flavoring agent, A compound, a silicate, a buffer, a coloring agent, an extracting agent, an oligosaccharide, and the like, and may further include, but is not limited to, a feed mixture.
  • the compound feed commonly used in the feed composition for fish includes any one or more protein sources selected from fish meal, casein, bone meal, and shrimp powder, or any one or more carbohydrate sources selected from sweet potato starch, potato starch, wheat starch, But the present invention is not limited thereto. Even if it is used in combination with the compound feed, it is possible to prevent or ameliorate parasitic infectious diseases according to the present invention, The effect is the same.
  • a method for preventing or treating parasitic infestation of fish comprising the step of directly or pondering a composition comprising an extract of porcine potatoes, a fraction thereof or a compound isolated therefrom as an active ingredient, to provide.
  • the present invention provides a method for preventing or treating parasitic infestation in a fish, comprising the step of administering the pharmaceutical composition or the feed additive composition containing the potato extract as an active ingredient directly to a fish or in a farm.
  • the method for preventing or treating a parasitic infectious disease of a fish may include any step in which the composition of the present invention is directly or indirectly delivered to a fish by including the step of administering the fish directly or in a farm.
  • the purpose of the present invention may be accomplished by directly injecting or feeding fish, and may also be accomplished by means of bathing or eating.
  • the effective concentration of the composition may be coated on the feed and fed to fish having lesions due to parasitic infectious disease, but is not limited thereto.
  • the dose of the composition may vary depending on the weight of the fish to be treated, the health condition, the administration time, and the severity of the disease.
  • Pork potatoes were thoroughly washed with water, allowed to dry naturally for 5-7 days, and then cut. 1.2 kg of methanol was added to 50 kg of cut pork potato, and the mixture was extracted at room temperature for 5 days and then filtered. It was concentrated under reduced pressure, lyophilized and powdered.
  • the control section is flushed with clean sea water and the compound section is flushed with the substance to be tested.
  • Mixed section is a section where control and compound sections are mixed and drained.
  • the sea lice are located at the point where the mixed section starts and the movement is observed.
  • the interpretation of the experimental results is carried out in the opposite direction in which the test substance flows, that is, the control section and the mixed section section), the sea lice effect was confirmed by analyzing how long the sea lice moved and stayed. (See Fig. 1)
  • Con.1 was treated with sea water as a control
  • OH3_A was treated with 1 mg / ml of potato potatoes
  • OH3_B was treated with 0.5 mg / ml of potato potato
  • the sea lice did not move to other sections because the sea water flowed in all sections of the Y-tube chamber and the sea lice stay time in OH3_A treated with 1 mg / time spent) was about 52% in the control section, about 47% in the mixed section, about 1% in the compound section, and in the OH3_B treated with porcine potato 0.5 mg / Time spent was about 43% in the control section, about 49% in the mixed section, and about 8% in the compound section.
  • Fig. 3 (a) about 70% of the sea lice survive in the control without any treatment, but as the concentration of the potato extract is increased, the alive population decreases The number of dead species increased. In the case of 1mg / ml of potato extract, 50% (LD50) of sea lice population was dead, and 50% (EC50) of sea lice at 0.08mg / ml was in Moribund state (Fig. 3 (b)). As shown in Fig. 3 (b)
  • the potato extract of the present invention or its fractions have anti-sea lice activity, and thus can be used for the prevention or treatment of parasitic infectious diseases of fish, for the prevention of parasites, and for the control thereof.
  • the present invention is recognized as an industrial applicability in the fields of pharmaceutical biotechnology and agriculture and fisheries.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

La présente invention concerne une composition pour la prévention ou le traitement de maladies infectieuses parasitaires chez les poissons, comprenant un extrait d'artichaut de Jérusalem ou une fraction de celui-ci en tant que principe actif et, plus spécifiquement, une composition pharmaceutique pour la prévention ou le traitement des maladies provoquées par une infection par les poux de mer, qui sont des parasites des poissons, une composition d'additif alimentaire pour la prévention ou le soulagement desdites maladies, et une méthode pour la prévention ou le traitement de maladies infectieuses parasitaires chez les poissons, comprenant l'étape consistant à introduire lesdites compositions directement dans les poissons ou dans un élevage de poissons.
PCT/KR2018/001248 2018-01-29 2018-01-29 Composition pour la prévention ou le traitement d'infections parasitaires chez les poissons, comprenant un extrait d'artichaut de jérusalem ou une fraction de celui-ci WO2019146825A1 (fr)

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PCT/KR2018/001248 WO2019146825A1 (fr) 2018-01-29 2018-01-29 Composition pour la prévention ou le traitement d'infections parasitaires chez les poissons, comprenant un extrait d'artichaut de jérusalem ou une fraction de celui-ci

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PCT/KR2018/001248 WO2019146825A1 (fr) 2018-01-29 2018-01-29 Composition pour la prévention ou le traitement d'infections parasitaires chez les poissons, comprenant un extrait d'artichaut de jérusalem ou une fraction de celui-ci

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059225A1 (fr) * 2006-11-13 2008-05-22 Biotec Pharmacon Asa Traitement d'une infestation ectoparasitaire
KR20140049673A (ko) * 2012-10-18 2014-04-28 반계선 함초, 민들레, 생강나무 등 125가지의 원재료를 생물의 물성에 따라 CO2(또는 N2) Carrier Gas를 이용하여 추출농축, 설탕에 절임에 의한 천연발효 효소법에 의해 추출 및 Microwave와 Filter를 이용하여 추출한 추출물들을 혼합발효숙성하여 제조한 조성물과 그 조성방법
KR20160027859A (ko) * 2014-09-02 2016-03-10 정창락 돼지감자 알코올 추출액을 유효성분으로 포함하는 뽕나무이의 방제용 농약 조성물
KR101737271B1 (ko) * 2016-06-04 2017-05-18 김상덕 오메가-3을 함유한 천연추출물 및 이의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059225A1 (fr) * 2006-11-13 2008-05-22 Biotec Pharmacon Asa Traitement d'une infestation ectoparasitaire
KR20140049673A (ko) * 2012-10-18 2014-04-28 반계선 함초, 민들레, 생강나무 등 125가지의 원재료를 생물의 물성에 따라 CO2(또는 N2) Carrier Gas를 이용하여 추출농축, 설탕에 절임에 의한 천연발효 효소법에 의해 추출 및 Microwave와 Filter를 이용하여 추출한 추출물들을 혼합발효숙성하여 제조한 조성물과 그 조성방법
KR20160027859A (ko) * 2014-09-02 2016-03-10 정창락 돼지감자 알코올 추출액을 유효성분으로 포함하는 뽕나무이의 방제용 농약 조성물
KR101737271B1 (ko) * 2016-06-04 2017-05-18 김상덕 오메가-3을 함유한 천연추출물 및 이의 제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S. A. EL GENGAIHI ET AL.: "Molecular characterizations and antimicrobial activities of chicory and jerusalem artichoke plants", INTERNATIONAL JOURNAL OF ACADEMIC RESEARCH, vol. 1, 2009, pages 66 - 71, XP055629455 *

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