WO2019142548A1

WO2019142548A1 - Main module, utility module, module unit and module system

Info

Publication number: WO2019142548A1
Application number: PCT/JP2018/045545
Authority: WO
Inventors: 和田　剛志; 郁朗末松; 雪絵高島; 泰二宮; 隆朗川島; 類佐藤
Original assignee: 鹿島建設株式会社
Priority date: 2018-01-17
Filing date: 2018-12-11
Publication date: 2019-07-25
Also published as: JP6553319B1; SG11202003481QA; JPWO2019142548A1

Abstract

According to the present invention, in each of main module 100A-100T, the vertical height of a ceiling panel 111 can be changed in a ceiling module 110, and the height of the space between the ceiling panel 111 and a floor panel 121 can be changed in a floor module 120 having a floor panel 121. An under-floor module 130 is moved along a floor surface by a moving part 400, the main modules 100A-100T are connected to other main modules 100A-100T to maintain airtightness of the space between the ceiling panel 111 and the floor panel 121.

Description

Main module, utility module, module unit and module system

The present invention relates to a main module, a utility module, a module unit and a module system.

Patent Document 1 discloses a modular unit for producing a medical product. The modular unit is moved to the deployment location by being pushed over the air bearings, casters or pallets. The modular unit is connected to a power source and a water source.

JP, 2014-98545, A

By the way, in the pharmaceutical related facilities, there may be a case where a partial change of the facilities etc. is required. However, in the above-mentioned technology, the response to partial change of facilities etc. is insufficient, and improvement is desired.

Then, this invention aims at providing the main module, utility module, module unit, and module system which can improve the freedom degree in the pharmaceutical relevant facility.

One aspect of the present invention is a sealing module having a sealing panel capable of changing the height in the vertical direction, a floor module integrated with the sealing module under the sealing module, and a floor module having a floor panel, and a floor module under the floor module. And an under-floor module having a moving part moving along the floor surface, the main module sealing panel and the floor of the main module's sealing module connected to each other and connected to each other It is a main module that can maintain the airtightness of the space between the floor panel of the module.

According to this configuration, in the main module, the vertical height of the sealing panel can be changed in the sealing module, and integrated with the sealing module below the sealing module, and in the floor module having the floor panel, the sealing module The height of the space between the sealing panel and the floor panel can be freely changed. In addition, the under floor module integrated with the floor module below the floor module is moved along the floor by the moving unit, and the main module is connected to the other main module and the sealing module of the main module connected to each other Because it is possible to maintain the air tightness of the space between the ceiling panel of the floor module and the floor panel of the floor module, the space between the sealing panel and the floor panel can be vertically It can be scaled up, down and modified horizontally, and it can improve the freedom in medical facilities.

In this case, in a space between the sealing panel of the sealing module of the main module and the floor panel of the floor module, a partition maintaining airtightness is not disposed at the boundary of the main module coupled to the other. The state may be selectable.

According to this configuration, in the space between the sealing panel of the sealing module of the main module connected to each other and the floor panel of the floor module, a state and arrangement in which a partition maintaining airtightness is disposed at the boundary of the main module connected to each other Since it is possible to select between the non-disclosed state, the space between the sealing panel and the floor panel can be freely partitioned depending on the situation of the pharmaceutical related facility, and the degree of freedom in the pharmaceutical related facility is further enhanced. It can be improved.

In addition, it is possible to select whether the partition for partitioning the space between the sealing panel of the sealing module of one main module and the floor panel of the floor module while maintaining airtightness is placed or not. May be.

According to this configuration, there are disposed and not disposed partitions dividing the space between the sealing panel of the sealing module of one main module and the floor panel of the floor module while maintaining airtightness. And the space between the sealing panel and the floor panel can be finely divided according to the situation of the pharmaceutical related facility, and the degree of freedom in the pharmaceutical related facility can be further improved. .

Another aspect of the present invention is a utility unit for supplying or receiving any of gas, liquid, power and signal to a main module moving along the floor, and a utility unit for the floor. And a moving unit for moving along.

According to this configuration, the utility module having the utility section for supplying or receiving any of gas, liquid, power and signal to the main module moving along the floor surface Since the unit is moved along the floor surface, the degree of freedom of the path for supplying gas etc. to the main module is improved, and the degree of freedom in medical facilities can be improved.

Another aspect of the present invention is a module unit provided with the main module of the present invention and the utility module of the present invention.

Another aspect of the present invention is a module system including the module unit of the present invention in an outer space partitioned from the outside.

According to the main module, utility module, module unit and module system of one aspect and other aspects of the present invention, it is possible to improve the degree of freedom in pharmaceutical related facilities.

It is a top view showing a module system concerning an embodiment. It is the figure which expanded the range shown by X of FIG. It is a perspective view showing an outline of a main module of an embodiment. It is a perspective view which shows the state which isolate | separated the main module of embodiment into the sealing module, the floor module, and the under-floor module. (A) and (B) is a figure which shows operation | movement of a moving part. (A) is a figure which shows the connection of a main module and a utility module, (B) is a figure which shows the detail of (A). It is a perspective view showing the outline of the utility module of an embodiment. It is a perspective view which shows the connection of a main module and a clean corridor. (A), (B), (C), (D), (E) and (F) are plan views showing an example of the change of the arrangement of the main module of the embodiment. (A), (B), (C), (D), (E) and (F) are plan views showing an example of the change of the arrangement of the main module of the embodiment. (A), (B) and (C) is a top view which shows the other example of arrangement | positioning of the main module of embodiment. It is a top view which shows the other example of the main module of embodiment, a utility module, and a module unit. (A), (B), (C), (D) and (E) are perspective views showing other examples of the main module of the embodiment.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Main modules, utility modules, module units and module systems according to the embodiments of the present invention described below are products for manufacturing, research, testing and experiments of medicines in medical facilities, for example, biopharmaceuticals. It is a thing to manufacture.

As shown in FIG. 1, the module system 1 of the present embodiment includes a module unit 1000 in an outer space 5 partitioned from the outside by an outer wall 2 of a building, a ceiling, a floor surface, and the like. As shown in FIG. 1, the modular system 1 may be provided with an inner wall 3 that defines a machine room 4 of the building and a clean corridor 6 that crosses the inside of the building, in addition to the outer wall 2 of the building. Outer shell space 5 may be separated from the outside by outer wall 2 and inner wall 3 of the building as shown in FIG. 1. Also, the outer space 5 may be an area surrounded by the inner wall 3 inside the area surrounded by the outer wall 2 of the building.

As shown in FIGS. 1 and 2, the module unit 1000 includes main modules 100A to 100T and

utility modules

200 and 300. As described later, each of the main modules 100A to 100T and the

utility modules

200 and 300 of the module unit 1000 is movable, can be connected and separated with each other, and can be changed in arrangement.

In the outer space 5, a plurality of main modules 100A to 100T having the same rectangular shape in plan view are arranged. Each of the plurality of main modules 100A to 100T is connected to each other at the long side of the rectangular shape. A corridor contact wall 101, which is a portion of one rectangular short side of each of the plurality of main modules 100A to 100T, is connected to the clean corridor 6. The main modules 100A to 100T accommodate, for example, biopharmaceutical manufacturing facilities as described later.

The utility module connection wall 102, which is a portion of the other short side of each of the plurality of main modules 100A to 100T, is a rectangle of the utility module 200 having substantially the same size and shape as the main modules 100A to 100T in plan view. It is connected to the site of one long side of the ring. The other long side portion of the rectangular shape of the utility module 200 is connected to the long side portion of the rectangular shape of the utility module 300 having substantially the same size and shape as the utility module 200 in plan view. The

utility modules

200 and 300 supply or receive any of gas, liquid, power, and signals to the main modules 100A to 100T as described later.

The ratio of the length of the rectangular short sides to the long sides of the main modules 100A to 100T and the

utility modules

200 and 300 is an integer ratio of 1: 5. Therefore, as shown in FIG. 2, in the main modules 100A to 100T and the

utility modules

200 and 300, utility module connecting walls 102 of short side portions such as five main modules 100P to 100T connected to each other at long side portions. Are standardized so that the combined length and the length of the long side of one utility module 200 coincide with each other.

For example, the main module 100A to 100T and the

utility module

200, 300 have a length of 11700 mm or less at one long side of the rectangular shape so that the container can be transported by a high cube container of a marine container, and the short side Length is 2200 mm or less and height is 2370 mm or less. The ratio of the length of the rectangular short sides to the long sides of the main modules 100A to 100T and the

utility modules

200 and 300 may be an integer ratio other than 1: 5. In addition, the ratio of the length of the short side to the long side of the rectangular shape of the main modules 100A to 100T and the

utility modules

200 and 300 is the total length of the short sides of the plurality of main modules 100A to 100T and If it is not necessary to match the length of the long side of the utility module 200, it may be other than an integer ratio.

The duct 140 and branch pipes leading to the utility module connection wall 102 of the main modules 100A to 100T and the duct 240 and main pipes leading to the long side of the utility module 200 are provided at predetermined positions. , Are standardized to be connected to each other. The duct 240 and the like communicating with the other long side of the utility module 200 and the ducts such as the air conditioner 361 and the exhaust fan 362 communicating with the long side of the utility module 300 are provided at predetermined positions. It is standardized to be connected to each other.

As shown in FIGS. 1 and 2, the outermost main module 100A and the main module 100T among the main modules 100A to 100T connected to each other are at the outermost long sides of the main modules 100A to 100T connected to each other. The portion is provided with a side wall 103 which maintains airtightness. The space surrounded by the corridor contact wall 101, the utility module connection wall 102 and the side wall 103 of the main modules 100A to 100T is kept airtight and the cleanliness management is performed.

Further, as shown in FIG. 2, a side wall 103 which is a partition maintaining airtightness is disposed at the boundary between the

main modules

100Q and 100R connected to each other and the boundary between the

main modules

100S and 100T. Moreover, the partition 104 which divides a part of space, such as one main module 100P, maintaining airtightness is arrange | positioned.

As shown in FIG. 1, in the outer space 5, a module unpacking room 7 for unpacking the main modules 100A to 100T and the

utility modules

200 and 300 carried in from the outside of the module system 1 has an openable door. Through. A product warehouse 15 is arranged around the module unpacking room 7. On the other side of the clean corridor 6 on the side where the main modules 100A to 100T are in contact, the washing room 8, cell bank room 9, changing

rooms

10 and 11, toilet 12, management room 13 and raw material storage 14 are adjacent. .

The cleanliness of the clean corridor 6, the washing room 8, the cell bank room 9, the changing

rooms

10, 11 and the raw material storage 14 is managed. Thus, in FIG. 1, the shaded area is a clean room with cleanliness control, and the unshaded area has no cleanliness management. A clean room is a limited space in which cleanliness management is performed, and suspended particles in the air and suspended microorganisms are managed to a limited cleanliness level or less, and are supplied to the space. It means a space where the required cleanliness for materials, chemicals, water, etc. is maintained.

For example, each of the biopharmaceutical manufacturing processes is assigned to the main modules 100A to 100T. A clean corridor 16 and a pass room 17 are assigned to the main module 100A. A seed chamber 18 and a weighing chamber 19 are assigned to the

main modules

100B and 100C. A culture room 20 is assigned to the main modules 100D to 100G, and a pass room 17 is assigned to the

main modules

100D and 100G therein. The first purification chamber 21 is assigned to the main modules 100H to 100Q, and the pass room 17 is assigned to the

main modules

100P and 100Q therein. The second purification chamber 22 and the dispensing chamber 23 are allocated to the

main modules

100R and 100S, and the pass room 17 is allocated in the section of the dispensing chamber 23 of the main module 100S therein. A clean corridor 16 and a pass room 17 are assigned to the main module 100T.

The side wall 103 and the partition wall 104 which divide the space of each of the main modules 100A to 100T while keeping airtightness are freely disposed, removed, and moved in position, and therefore manufacturing of medicines such as a biopharmaceutical manufacturing process for them. It is also possible to change the assignment of research, test and experimental processes. Further, as described later, since the main modules 100A to 100T and the

utility modules

200 and 300 are movable along the floor surface of the outer space 5, enlargement, reduction, and modification of each manufacturing process of biopharmaceuticals are also possible. is there.

Hereinafter, the main modules 100A to 100T of the present embodiment will be described in detail. Since the main modules 100A to 100T have the same structure, the main module 100E will be described below as a representative. As shown in FIG. 3 and FIG. 4, the main module 100E accommodates a biopharmaceutical manufacturing facility 150. The main module 100E includes a sealing module 110, a floor module 120 and an under floor module 130, which are stacked in three tiers in the vertical direction. The sealing module 110, the floor module 120 and the underfloor module 130 are connectable and separable to each other, standardized, and partially replaceable.

The sealing module 110 is a module that constitutes the ceiling and the ceiling and back of the main module 100E. The sealing module 110 has a sealing panel 111 whose height in the vertical direction can be changed. Having the sealing panel 111 capable of changing the height in the vertical direction, for example, the main module 100E changes the sealing module 110 having the sealing panels 111 of different heights according to the required height, It means that the height of the sealing panel 111 can be changed. In addition, having the sealing panel 111 capable of changing the height in the vertical direction means, for example, the sealing panel 111 by adjusting the height of the sealing panel 111 in a state where the sealing module 110 is connected to the floor module 120. It means that the height of the can be changed.

As shown in FIG. 4, in addition to the duct 140 and the branch piping 141 connected to the duct 240 and the main piping of the utility module 200, the sealing module 110 also includes a HEPA filter (High Efficiency Particulate Air Filter) unit, a lighting fixture, and a utility. Valves and cables are installed. In addition, the sealing module 110 has the corridor contact wall 101 and the utility module connection wall 102 at least in the range of height below the sealing panel 111, and in the case where the floor module 120 has the side wall 103 and the partition 104, at least the sealing panel. The side wall 103 and the partition wall 104 are provided in the range of height of 111 or less.

As shown in FIG. 3 and FIG. 4, the floor module 120 is a module that constitutes a wall by the corridor contact wall 101 and the utility module connection wall 102 and the like and a floor by the floor panel 121 in the main module 100E. The floor module 120 is integrated with the sealing module 110 below the sealing module 110 and has a floor panel 121, and for example, a biopharmaceutical manufacturing facility 150 in a space between the sealing panel 111 and the floor panel 121 of the sealing module 110. To accommodate.

The manufacturing equipment 150 is, for example, a culture tank, a wagon for a pump, a culture medium preparation tank, a column, a chromatography apparatus, a buffer preparation tank, and the like. The manufacturing facility 150 may be a single-use facility, and may or may not be fixed to the floor module 120. Also, in the manufacturing facility 150, one higher than the frame of the main module 100E is once removed and transferred separately.

The floor module 120 may have a floor panel 121 whose height in the vertical direction can be changed. Having the floor panel 121 capable of changing the height in the vertical direction means, for example, that the main module 100E can replace the floor module 120 having the floor panels 121 of different heights according to the required height. It means that the height of the floor panel 121 can be changed. Further, having the floor panel 121 capable of changing the height in the vertical direction means, for example, adjusting the height of the floor panel 121 in a state where the floor module 120 is connected to either the sealing module 110 or the under floor module 130. By doing this, it means that the height of the floor panel 121 can be changed.

Note that changing the height of the floor panel 121 of the floor module 120 changes the height from the floor surface of the outer space 5 of the under floor module 130 or changes the height of the outer space 5 from the floor surface. This may be done by coupling the floor module 130 to the floor module 120.

For example, in addition to the biopharmaceutical manufacturing facility 150, the floor module 120 is provided with a suction port, a LAN (Local Area Network), outlets, a drainage port for equipment, a drainage gutter, and the like. In addition, the floor module 120 has a corridor contact wall 101 and a utility module connection wall 102 in a range of height at least the floor panel 121 or more. In addition, when the floor module 120 is disposed at the outermost side of the main modules 100A to 100T in which the main modules 100E are connected to each other, a part of the outermost long side of the main modules 100A to 100T connected to each other. The side wall 103 which keeps airtightness in the range of height of the floor panel 121 or more at least. In addition, the floor module 120 may be airtight at the boundary of the main modules 100A to 100T connected to each other in the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120. It is possible to select the state in which the side wall 103 which is a partition maintaining the property is disposed and the state in which it is not disposed.

The main module 100E has the sealing module 110 having the side wall 103, the sealing module 110 having the side wall 103, and the sealing module 110 having no side wall 103, and the floor module having the side wall 103 can be selected. By exchanging with 120, it means that the state in which the side wall 103 is disposed and the state in which the sidewall 103 is not disposed can be selected. In addition, the main module 100E can select the state in which the side wall 103 is arranged and the state in which the side wall 103 is not arranged, in a state where the floor module 120 is connected to either the sealing module 110 or the underfloor module 130. The installation or removal of the side wall 103 means that the state in which the side wall 103 is disposed and the state in which the sidewall 103 is not disposed can be selected.

In addition, the floor module 120 is provided with a partition 104 that partitions a part of the space between the sealing panel 111 of the sealing module 110 of one main module 100E and the floor panel 121 of the floor module 120 while maintaining airtightness. A state and an unarranged state can be selected. The main module 100E is configured such that the sealing module 110 having the dividing wall 104, the floor module 120 and the sealing module 110 not having the dividing wall 104, and the floor module are optional. By exchanging with 120, it means that the state in which the partition wall 104 is disposed and the state in which the partition wall 104 is not disposed can be selected. In addition, the main module 100E allows the floor module 120 to be connected to either the sealing module 110 or the under floor module 130, in which the state where the partition wall 104 is arranged and the state where it is not arranged can be selected. By installing or removing the partition wall 104, it means that the state in which the partition wall 104 is arranged and the state in which the partition wall 104 is not arranged can be selected.

The under floor module 130 is a module that constitutes an underfloor space in the main module 100E. As shown in FIGS. 4, 5A and 5B, the under floor module 130 is integrated with the floor module 120 below the floor module 120, and along the floor surface of the outer space 5 on the lower surface thereof. It has a mounting recess 131 to which the moving part 400 to be moved is attached.

As shown in FIG. 5 (A), the moving part 400 is a small hole provided in the outer wall of the air introducing part 401 into which compressed air is introduced from the outside and the compressed air introduced by the air introducing part 401 while expanding. And an air cushion portion 402 for ejecting compressed air to the lower surface of the moving portion 400. As shown in FIG. 5A, in a state where compressed air is not supplied to the air introduction portion 401, the air cushion portion 402 is contracted, and the under floor module 130 is landed on the floor surface. As shown in FIG. 5B, in the state where compressed air is supplied to the air introduction portion 401, the air cushion portion 402 is expanded, and the inside of the air cushion portion 402 is filled with the compressed air. Compressed air is ejected from the small holes in the outer wall of the air cushion portion 402, and leaks to the outside while forming a thin air film which is a slight gap between the air cushion portion 402 and the floor surface.

Therefore, the under floor module 130 can be manually moved along the floor surface of the outer space 5 with the floor module 120 in a state where the manufacturing facility 150 is installed on the floor panel 121 and the sealing module 110 connected. It is. In addition, the moving part 400 is detachable to the attachment recessed part 131 of the under-floor module 130 of the main module 100E. Therefore, the moving part 400 does not have to be permanently attached to the mounting recess 131 of the underfloor module 130 of the main module 100E, and only when the main module 100E is moved, the moving part 400 of the underfloor module 130 of the main module 100E. It may be temporarily attached to the attachment recess 131. The moving unit 400 may move by a wheel or the like. In addition, the moving unit 400 may be movable along the floor surface of the outer space 5 by an electric motor, an internal combustion engine, or the like regardless of human power.

As shown in FIG. 4, the underfloor module 130 is provided with a drain pipe 132, a vent pipe, and the like. The under floor module 130 does not have the corridor contact wall 101, the utility module connection wall 102 and the side wall 103, and is composed only of a frame for supporting the floor module 120. Therefore, the under floor module 130 is exposed to a space such as the outer space 5 and is disposed in a space where cleanliness control is not performed. In addition, the under floor module 130 may be comprised only with the frame in which the drainage pipe 132, the ventilation pipe, etc. are not installed. In this case, necessary piping may be installed in the floor module 120.

It should be noted that either between the sealing module 110 and the floor module 120 or between the floor module 120 and the under floor module 130 is constantly integrated, and the main module 100E can be separated only in two stages in the vertical direction. Good.
In addition, the main module 100E may be constantly integrated as a whole and can not be separated. Alternatively, any of the sealing module 110, the floor module 120, and the under floor module 130 may be further divided in the vertical direction, and the main module 100E may be separated in four or more stages in the vertical direction.

The main modules 100A to 100T can be connected to and separated from other main modules 100A to 100T and

utility modules

200 and 300, respectively. The main modules 100A to 100T can maintain the airtightness of the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120.

Further, the main modules 100A to 100T can maintain the airtightness of the space defined by the sealing panel 111, the floor panel 121, the side wall 103, and the partition 104 in the main modules 100A to 100T connected to each other. After the sealing panels 111, the floor panels 121, the side walls 103 and the dividing walls 104 of the main modules 100A to 100T connected to each other are disposed at arbitrary positions, for example, the joints of the sealing panels 111, the floor panels 121, the side walls 103 and the dividing walls 104 By filling the sealing material, airtightness is ensured. On the corridor contact wall 101 connected via the clean corridor 6 and the clean corridor 16 or the pass room 17 of the main modules 100A to 100T, hatches, doors, etc. are installed as necessary.

As shown in FIGS. 6A and 6B, the connection positions of the duct 140 of the main module 100E, the branch piping 141 and the drainage pipe 132, and the duct 240 of the utility module 200 and the main piping 241 are standardized. There is. For example, even when there is no piping or the like to be connected to the main module 100E side, the duct 240 and the main piping 241 of the utility module 200 are disposed. Connection between the duct 140 of the main module 100E, the branch piping 141, the drainage pipe 132, the ventilation pipe, etc. and the duct 240 of the utility module 200 and the main piping 241 is provided with a flexible connection 500 for adjustment of installation error as necessary. It is done. The main pipe 241 of the utility module 200 is disposed at a lower position than the drain pipe 132 of the main module 100E.

Hereinafter, the

utility modules

200 and 300 of the present embodiment will be described in detail.

Utility modules

200 and 300 are

utility units

210 and 310 for supplying or receiving any of gas, liquid, power and signals to and from main modules 100A to 100T moving along the floor surface of outer shell space 5. And a moving unit 400 for moving the utility unit along the floor of the outer space 5. The

utility modules

200 and 300 are exposed to a space such as the outer space 5 and are arranged in an area where cleanliness management is not performed.

Further, in the present embodiment, it is divided into a utility module 200 which is a first utility module and a utility module 300 which is a second utility module. The utility module 200 and the utility module 300 can be connected and separated with each other.

The utility module 200, which is the first utility module, is the utility section 210, and moves the path section, which is any of gas, liquid, power, and signal paths, and the path section along the floor of the outer space 5. And a moving unit 400. The second utility module, the utility module 300, is a utility unit 310, and has a mechanical unit which is any one of a gas, liquid, power and signal supply source and reception destination, and a supply / reception destination part. And a moving unit 400 configured to move along the floor surface of the space 5.

In connection with the main modules 100A to 100T, the utility module 300 which is the second utility module is arranged closer to the outer space 5 than the utility module 200 which is the first utility module.

As shown in FIGS. 2 and 6A, the utility module 200 receives gas, liquid, power, and signals for the main modules 100A to 100T moving along the floor of the outer space 5 while accommodating the manufacturing facility 150. The duct 240 and the main piping 241 etc which are the route section which is either route and the duct 240 which is the route section and the utility section 210 etc etc along the floor surface of the outer space 5 And a mounting recess 231 to which the moving unit 400 to be moved is attached. The duct 240, the main piping 241, etc. are unitized and integrated with the utility module 200, and are carried into the outer space 5 together with the utility module 200 and connected to the main modules 100A to 100T. As shown in FIG. 2, the duct 240 of the utility module and the main pipe 241 may be connected to the utility connection pipe 600 of the permanent installation of the module system 1.

As shown in FIG. 7, the utility module 300 receives, via the utility module 200, gas, liquid, power and signals for the main modules 100A to 100T moving along the floor of the outer space 5 while accommodating the manufacturing facility 150. The air conditioner 361, the exhaust fan 362, the production power panel 363, the automatic control panel 364, etc., which is the mechanical unit which is any of the supply source and the receiving destination and the utility unit 310, and the mechanical unit is the utility unit. And a mounting recess 331 to which a moving unit 400 for moving the air conditioner 361 or the like 310 along the floor surface of the outer space 5 is attached. The cable connection of the production power panel 363 or the like is simplified by cable connection or the like.

Note that the utility module 200, which is the first utility module, and the utility module 300, which is the second utility module, do not necessarily have to be mutually connectable and separable, and may be constantly integrated. .

Further, similarly to the main modules 100A to 100T, also in the

utility modules

200 and 300, the moving unit 400 is detachably attachable to the attachment recesses 231 and 331 of the

utility modules

200 and 300. Therefore, the moving unit 400 does not have to be permanently attached to the mounting

recesses

231 and 331 of the

utility modules

200 and 300, but only when the

utility modules

200 and 300 move. 231, 331 may be temporarily attached.

Further, in the present embodiment, the size and shape of the

utility modules

200 and 300 correspond to the size and shape of the main modules 100A to 100T so that the high cube container can transport the marine container. However, the size and shape of the

utility modules

200 and 300 may be different sizes and shapes that do not necessarily correspond to the main modules 100A to 100T.

As shown in FIG. 8, the clean corridor 6 connected to the corridor contact wall 101 of the main modules 100A to 100T corresponds to the outer space 5 corresponding to the size and the shape of the corridor contact wall 101 of the main modules 100A to 100T. A frame 62 having an opening 63 is provided. The opening 63 of the frame 62 connected to the corridor contact wall 101 of the main modules 100 A to 100 T is closed by the corridor contact wall 101. The opening 63 of the frame 62 not connected to the corridor contact wall 101 of the main modules 100A to 100T is closed by the panel 64. The floor 61 of the clean corridor 6 is also raised to the same height in accordance with the height of the floor panels 121 of the main modules 100A to 100T.

Hereinafter, vertical and horizontal enlargement, reduction, and modification of a pharmaceutical related facility such as a space in which the manufacturing facility 150 according to the present embodiment is accommodated will be described. As shown in FIG. 9A, when the main modules 100A to 100E connected to each other are arranged, the utility module 300 can be disconnected from the utility module 200, and the floor surface of the outer space 5 can be moved. .

In the operation described below, when the space for moving the main modules 100A to 100E and the

utility modules

200 and 300 in the outer space 5 is insufficient, the main module 100A is removed by removing the outer wall 2 as appropriate. 100E and the space for moving the

utility modules

200 and 300 can be supplemented.

As shown in FIG. 9B, the utility module 200 is disconnected from the main modules 100A to 100E, and the floor surface of the outer space 5 is moved. The floor surface of the outer space 5 may be moved by releasing the connection with the main modules 100A to 100E while the utility module 200 and the utility module 300 are integrated without being separated.

As shown in FIG. 9C, the floor of the outer space 5 is set such that the main modules 100D of the main modules 100A to 100E connected to each other are disconnected from the main module 100C, and the

main modules

100D and 100E shift outward. You can move the face. Thus, a gap for inserting a new main module 100X as shown in FIG. 9D is formed between the

main modules

100C and 100D.

As shown in FIG. 9D, the new main module X unpacked in the module unpacking chamber 7 is moved on the floor surface of the outer space 5 and inserted between the

main modules

100D and 100E, and the main module It is connected with 100D and 100E. Also,

utility modules

200 and 300 for the new main module X are prepared. As shown in FIG. 9E, the utility module 200 is connected to the main modules 100A to 100E and 100X, and the utility module 300 is connected to the utility module 200. As a result, the pharmaceutical related facilities such as the space in which the manufacturing facility 150 is accommodated are expanded in the horizontal direction.

The height of the sealing panel 111 of the sealing module 110 of the main modules 100A to 100E, 100X is appropriately changed. Further, the arrangement of the side wall 103 and the partition wall 104 of the sealing module 110 of the main modules 100A to 100E and 100X is appropriately changed. As a result, vertical and horizontal enlargement, reduction, and modification of pharmaceutical-related facilities, such as a space in which the manufacturing facility 150 is accommodated, are performed.

On the other hand, in the case where reduction of a pharmaceutical related facility such as a space in which the manufacturing facility 150 is accommodated is performed in the horizontal direction, the same operation as in FIG. 9A to FIG. For example, the main module 100C is disconnected from the

main modules

100B and 100D, and the floor surface of the outer space 5 is moved. The main module 100B and the main module 100D are brought close to each other to fill the gap between the

main modules

100B and 100D, and the main module 100B and the main module 100D are connected. Thereby, the reduction of the pharmaceutical related facilities such as the space where the manufacturing facility 150 is accommodated is performed in the horizontal direction.

Further, after operations similar to those of FIGS. 9A to 9B are performed as shown in FIGS. 10A to 10B, as shown in FIG. 10C, the main module 100C is obtained. May release the connection with the

main modules

100B and 100D and move the floor surface of the outer shell space 5 to the module unpacking chamber 7 or the like. As shown in FIG. 10D, the main module 100Y is provided between the

main modules

100B and 100D with a partition 104 for dividing a space in which the manufacturing facility 150 is accommodated in a direction parallel to the long side of the main module 100Y. It is inserted, connected to the

main modules

100B and 100D, and replaced with the main module 100C. As shown in FIG. 10E and FIG. 10F, the

utility modules

200 and 300 are connected again. Thereby, the addition of the partition by the partition wall 104 changes the facilities related to the pharmaceutical equipment such as the space where the manufacturing facility 150 is accommodated, and changes the allocation of the process of manufacturing, research, testing and experiment of medicines such as biopharmaceuticals. .

Further, as shown in FIG. 11A, in a state where the main module 100C of FIG. 10C is removed from between the

main modules

100B and 100D, the side from which the main module 100C of the

main modules

100B and 100D is removed. The side wall 103 may be added to the long side, and the

utility modules

200 and 300 may be connected again. That is, the main modules 100A to 100T may not necessarily be arranged closely.

Further, as shown in FIG. 11B, the corridor contact wall 101, the utility module connection wall 102 and the side wall 103 of the main module 100A, the corridor contact wall 101 and the utility module connection wall 102 of the main module 100B, and the inner wall of the building. 3 and the corridor contact wall 101 and utility module connection wall 102 of the

main modules

100C and 100D, the corridor contact wall 101 of the main module 100E, the utility module connection wall 102 and sidewalls 103, and the inner wall of the building 3 The space partitioned by and may form a pharmaceutical related facility such as a space in which the manufacturing facility 150 is accommodated. That is, not only the main modules 100A to 100T but also the inner wall 3 of the building may form a space for accommodating the manufacturing facility 150.

Further, as shown in FIG. 11C, the outer space 5 surrounded by the outer wall 2 of the building is divided into two or more sections by the inner wall 3 of the building, and each section is divided by the main modules 100A to 100T or the like. Pharmaceutical related facilities such as a space where the manufacturing facility 150 is accommodated may be formed. In the movement of the main modules 100A to 100T and the

utility modules

200 and 300, the movement may be performed for each module unit 1000 in which the main modules 100A to 100T and the

utility modules

200 and 300 are connected.

According to the present embodiment, in the main modules 100A to 100T accommodating the manufacturing facility 150, in the sealing module 110, the height in the vertical direction of the sealing panel 111 can be changed, and the sealing module 110 and the sealing module 110 are In the floor module 120 which is integrated and has the floor panel 121, the height of the space for accommodating the manufacturing facility 150 can be increased to accommodate the manufacturing facility 150 in the space between the sealing panel 111 of the sealing module 110 and the floor panel 121. Can be changed to In addition, the under floor module 130 integrated with the floor module 120 below the floor module 120 is moved along the floor by the moving unit 400, and the main modules 100A to 100T are connected to other main modules 100A to 100T. Because it is possible to maintain the airtightness of the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T and the floor panel 121 of the floor module 120 connected to each other, Accordingly, the space in which the manufacturing facility 150 is accommodated can be freely expanded, reduced, and modified in the vertical direction and the horizontal direction, and the degree of freedom in pharmaceutical-related facilities can be improved. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be freely expanded, reduced, and modified in the vertical direction and the horizontal direction according to the situation of production of biopharmaceuticals, and the use in the production of biopharmaceuticals etc. It is possible to improve the degree of freedom.

Further, according to the present embodiment, in the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120, the boundary of the main modules 100A to 100T connected to each other Because it is possible to select between the state where the side wall 103, which is a partition maintaining air tightness, is arranged and the state where it is not arranged, the space where the manufacturing facility 150 is accommodated can be freely made according to the condition of medical facilities. It can be partitioned, and it can further improve the degree of freedom in pharmaceutical related facilities. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be freely partitioned according to the situation of production of biopharmaceuticals etc., and the degree of freedom of use in production of biopharmaceuticals etc. can be further improved. .

Further, according to the present embodiment, the partition wall 104 divides a part of the space between the sealing panel 111 of the sealing module 110 such as one main module 100E and the floor panel 121 of the floor module 120 while maintaining airtightness. Since it is possible to select between the arranged state and the unarranged state, the space where the manufacturing facility 150 is accommodated can be finely divided according to the situation of the pharmaceutical related facility, and freedom in the pharmaceutical related facility can be obtained. The degree can be further improved. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be finely divided according to the situation of production of biopharmaceuticals and the like, and the degree of freedom of use in production of biopharmaceuticals and the like can be further improved.

Further, according to the present embodiment, the supply and reception of any one of gas, liquid, power and signal to the main modules 100A to 100T moving along the floor of the outer space 5 while accommodating the manufacturing facility 150. In the

utility modules

200 and 300 including the main piping and duct 240 which is one of the utility parts that perform one of the functions, the air conditioner 361 and the like, the main piping and duct 240 which is the utility part and the air conditioner 361 are on the floor. Since the main modules 100A to 100T can be moved along, the degree of freedom of the path for supplying gas or the like to the main modules 100A to 100T can be improved, and the degree of freedom in medical-related facilities can be improved. In the present embodiment, it is possible to improve the degree of freedom of use in the manufacture of biopharmaceuticals and the like.

Also, since the

utility modules

200 and 300 are exposed to the space such as the outer space 5 and disposed in an area where cleanliness management is not performed, management, maintenance and maintenance of the

utility modules

200 and 300 Is easy. Further, in connection with the main modules 100A to 100T, the utility module 300 which is the second utility module is arranged closer to the outer space 5 than the utility module 200 which is the first utility module. While maintaining the connection between the utility module 200 and the main modules 100A to 100T, separate the utility module 300 having a mechanical part that requires maintenance from the utility module 200 having a path part that requires less maintenance, It can be moved and management, maintenance and maintenance of the utility module 300 are easy.

As mentioned above, although embodiment of this invention was described, this invention is implemented in various forms, without being limited to the said embodiment. For example, the main modules 100A to 100T do not necessarily have to accommodate the manufacturing facility 150, and may be applied to other uses besides manufacturing. The manufacturing facility 150 contained in the main modules 100A to 100T is not limited to the application of the production of biopharmaceuticals, and may be applied to the application of production, research, testing and experiments of other pharmaceuticals capable of maintaining airtightness. it can.

Also, the main modules 100A to 100T and the

utility modules

200 and 300 may be divisible, for example, in the direction of the long side. For example, in the situation shown in FIG. 9E, the utility module 200 divided into 1⁄5 of the length in the direction of the long side may be connected to the main module 100E. Further, in the situation shown in FIG. 9F, the utility module 200 is divided into 1⁄5 of the length in the direction of the long side, and the utility module is divided into 1⁄5 of the length in the direction of the long side. 300 may be linked. Thus, even when the main modules 100A to 100T in multiples of 5 are connected, the combined length of the utility module connecting walls 102 on the short sides of the main modules 100A to 100T connected to each other and the

utility modules

200 and 300 The length of the long side can be matched.

In addition, as shown in FIG. 12, for example, the module unit 1000 according to the present embodiment has a main module 100α in which the ratio of the length of the short side to the long side of the rectangular shape in plan view is an integer ratio of 1: 3 It may be configured by the utility modules 200α and 300α, and the main module 100β and the utility modules 200β and 300β, in which the ratio of the length of the short side to the long side of the rectangular shape in plan view is an integer ratio of 1: 2. . For example, in the module unit 1000 of the present embodiment, the short side and the long side of each of the main modules 100α and 100β may be connected to each other. In addition, the short sides of the main modules 100α and 100β and the short sides of the utility modules 200α, 200β, 300α, and 300β may be connected to each other.

Further, as shown in FIG. 13A, the main modules 100α and 100β may not have the side wall 103. Further, as shown in FIG. 13B, the main modules 100α and 100β may have the side wall 103 only on the long side. Further, as shown in FIG. 13C, the main modules 100α and 100β may have the side wall 103 only on the short side. Further, as shown in FIG. 13D, the main modules 100α and 100β may have sidewalls 103 on the short side and the long side. Further, as shown in FIG. 13E, the main modules 100α and 100β may have side walls 103 on the short side and the long side, and the space divided by the side walls may be further divided by the partition wall 104.

DESCRIPTION OF SYMBOLS 1 ... Module system, 2 ... outer wall, 3 ... inner wall, 4 ... machine room, 5 ... shell space, 6 ... clean corridor, 7 ... module unpacking room, 8 ... washing room, 9 ... cell bank room, 10, 11 ... changing clothes Room 12 12 Toilet 13 Management room 14 Raw material storage 15 Product warehouse 16 Clean corridor 17 Path room 18 Seed room 19 Measurement room 20 Culture room 21 21st 1 purification room 22 22 second purification room dispensing room 61 floor 62 frame 63 opening 64 panel 100A to 100T, 100X, 100Y main module 100α, 100β main Module, 101 ... Corridor contact wall, 102 ... Utility module connection wall, 103 ... Side wall, 104 ... Partition, 110 ... Sealing module, 111 ... Sealing panel, 120 ... Flow A module, 121: floor panel, 130: under floor module, 131: mounting recess, 132: drainage pipe, 140: duct, 141: branch piping, 150: manufacturing facility, 200: utility module, 200α, 200β: utility module, DESCRIPTION OF SYMBOLS 210 ... Utility part, 231 ... Mounting recessed part, 240 ... Duct, 241 ... Main piping, 300 ... Utility module, 300 alpha, 300 beta ... Utility module, 310 ... Utility part, 331 ... Mounting recessed part, 361 ... Air conditioner, 362 ... Exhaust fan , 363: power panel for production, 364: automatic control panel, 400: moving part, 401: air introduction part, 402: air cushion part, 500: flexible pipe for connection, 600: utility connection piping, 1000: module unit

Claims

A sealing module having a sealing panel whose height in the vertical direction can be changed;
A floor module integrated with the sealing module below the sealing module and having a floor panel;
An under-floor module integrated with the floor module below the floor module and having a moving unit moving along the floor surface;
The main module with
A main module capable of maintaining airtightness of a space between the sealing panel of the sealing module of the main module and the floor panel of the floor module connected to each other of the other main modules and connected to each other.
In a space between the sealing panel of the sealing module of the main module and the floor panel of the floor module connected to each other, a partition maintaining airtightness is arranged at the boundary of the main module connected to each other The main module according to claim 1, wherein the main module is optional.
And a state in which a partition is provided for partitioning a part of a space between the sealing panel of the sealing module of one of the main modules and the floor panel of the floor module while maintaining airtightness. The main module according to claim 1 or 2, which is selectable.
A utility unit for supplying or receiving any of gas, liquid, power and signal to the main module moving along the floor;
A moving unit for moving the utility unit along the floor surface.
A module unit comprising the main module according to any one of claims 1 to 3 and the utility module according to claim 4.
A module system comprising the module unit according to claim 5 in an outer space partitioned from the outside.