JP6553319B1 - Main module, utility module, module unit and module system - Google Patents

Abstract

In the main modules 100A to 100T, the height of the ceiling panel 111 can be changed in the ceiling module 110, and the height of the space between the ceiling panel 111 and the floor panel 121 in the floor module 120 having the floor panel 121. Change freely. The under floor module 130 is moved along the floor surface by the moving unit 400, the main modules 100 </ b> A to 100 </ b> T are connected to the other main modules 100 </ b> A to 100 </ b> T, and the space between the sealing panel 111 and the floor panel 121 is hermetically sealed. Keep sex.

Description

  The present invention relates to a main module, a utility module, a module unit, and a module system.

  Patent Document 1 discloses a modular unit for manufacturing a medical product. The modular unit is moved to the deployment location by being pushed over the air bearings, casters or pallets. The modular unit is connected to a power source and a water supply.

JP 2014-98545 A

  By the way, in the pharmaceutical related facilities, there may be a case where a partial change or the like of the facilities is required. However, in the above-mentioned technology, the response to partial change of facilities etc. is insufficient, and improvement is desired.

  Then, this invention aims at providing the main module, utility module, module unit, and module system which can improve the freedom degree in the pharmaceutical relevant facility.

  One aspect of the present invention is a sealing module having a sealing panel whose height in the vertical direction can be changed, a floor module having a floor panel integrated with the sealing module below the sealing module, and a floor module below the floor module. And an underfloor module having a moving part that moves along the floor surface, the main module being connected to other main modules and connected to each other, the sealing panel of the sealing module and the floor of the main module connected to each other It is a main module that can maintain the airtightness of the space between the floor panel of the module.

  According to this configuration, in the main module, the height of the ceiling panel can be changed in the ceiling module, and the ceiling module is integrated with the ceiling module below the ceiling module. The height of the space between the sealing panel and the floor panel can be freely changed. In addition, the under floor module integrated with the floor module below the floor module is moved along the floor by the moving unit, and the main module is connected to the other main module and the sealing module of the main module connected to each other It is possible to maintain the airtightness of the space between the sealing panel of the floor module and the floor panel of the floor module. It can be scaled up, down and modified horizontally, and it can improve the freedom in medical facilities.

  In this case, in the space between the sealing panel of the sealing module of the main module connected to each other and the floor panel of the floor module, the partition wall for maintaining airtightness is not arranged at the boundary of the main modules connected to each other. The state may be freely selectable.

  According to this configuration, in the space between the sealing panel of the sealing module of the main module connected to each other and the floor panel of the floor module, the state and arrangement in which the partition wall for maintaining airtightness is arranged at the boundary of the main modules connected to each other Since the space between the sealing panel and the floor panel can be freely divided according to the situation of the drug-related facility, the degree of freedom in the drug-related facility can be increased. Can be improved.

  In addition, it is possible to select between a state in which a partition that partitions a part of the space between the sealing panel of the sealing module of one main module and the floor panel of the floor module is kept airtight and a state in which no partition is provided. May be.

  According to this configuration, a state in which the partition wall that partitions a part of the space between the sealing panel of the sealing module of one main module and the floor panel of the floor module while maintaining airtightness is disposed and a state in which the partition is not disposed Since the space between the sealing panel and the floor panel can be finely divided according to the situation of the pharmaceutical related facility, the degree of freedom in the pharmaceutical related facility can be further improved. .

  In another aspect of the present invention, a utility unit that supplies or receives any of gas, liquid, power, and signal to the main module that moves along the floor surface, and the utility unit on the floor surface are provided. And a moving module that moves along the line.

  According to this configuration, in the utility module including the utility unit that supplies or receives any one of gas, liquid, power, and signal to the main module that moves along the floor surface, the utility is operated by the moving unit. Since the unit is moved along the floor surface, the degree of freedom of the path for supplying gas etc. to the main module is improved, and the degree of freedom in medical facilities can be improved.

  Another aspect of the present invention is a module unit provided with the main module of the present invention and the utility module of the present invention.

  Another aspect of the present invention is a module system including the module unit of the present invention in an outer space partitioned from the outside.

  According to the main module, the utility module, the module unit, and the module system according to one aspect and the other aspect of the present invention, the degree of freedom in a pharmaceutical-related facility can be improved.

It is a top view which shows the module system which concerns on embodiment. It is the figure which expanded the range shown by X of FIG. It is a perspective view which shows the outline of the main module of embodiment. It is a perspective view which shows the state which isolate | separated the main module of embodiment into the sealing module, the floor module, and the under-floor module. (A) and (B) is a figure which shows operation | movement of a moving part. (A) is a figure which shows the connection of a main module and a utility module, (B) is a figure which shows the detail of (A). It is a perspective view which shows the outline of the utility module of embodiment. It is a perspective view which shows the connection of a main module and a clean corridor. (A), (B), (C), (D), (E), and (F) are plan views showing examples of changing the arrangement of the main modules of the embodiment. (A), (B), (C), (D), (E), and (F) are plan views showing examples of changing the arrangement of the main modules of the embodiment. (A), (B) and (C) is a top view which shows the other example of arrangement | positioning of the main module of embodiment. It is a top view which shows the other example of the main module of embodiment, a utility module, and a module unit. (A), (B), (C), (D) and (E) are perspective views showing other examples of the main module of the embodiment.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The main module, utility module, module unit, and module system according to the embodiments of the present invention described below are for manufacturing, researching, testing, and experimenting a pharmaceutical in a pharmaceutical-related facility. It is a thing for manufacturing.

  As shown in FIG. 1, the module system 1 of the present embodiment includes a module unit 1000 in an outer space 5 partitioned from the outside by an outer wall 2 of a building, a ceiling, a floor surface, and the like. As shown in FIG. 1, the module system 1 may include an inner wall 3 that defines a machine room 4 of a building and a clean corridor 6 that traverses the interior of the building, in addition to the outer wall 2 of the building. Outer shell space 5 may be separated from the outside by outer wall 2 and inner wall 3 of the building as shown in FIG. 1. The outer space 5 may be an area surrounded by the inner wall 3 inside the area surrounded by the outer wall 2 of the building.

  As shown in FIGS. 1 and 2, the module unit 1000 includes main modules 100A to 100T and utility modules 200 and 300. As will be described later, each of the main modules 100A to 100T and the utility modules 200 and 300 of the module unit 1000 is movable, can be connected to and disconnected from each other, and their arrangement can be changed.

  In the outer shell space 5, a plurality of main modules 100A to 100T having the same rectangular shape in plan view are disposed. Each of the plurality of main modules 100 </ b> A to 100 </ b> T is connected to each other at the long side of the rectangular shape. A corridor contact wall 101 which is a portion of one rectangular short side of each of the plurality of main modules 100A to 100T is connected to the clean corridor 6. The main modules 100A to 100T accommodate, for example, biopharmaceutical manufacturing facilities, as described later.

  The utility module connecting wall 102 which is the other short side portion of the rectangular shape of each of the plurality of main modules 100A to 100T has a rectangular shape of the utility module 200 having substantially the same size and shape as the main modules 100A to 100T in plan view. It is connected with the part of one long side of the shape. The other long side portion of the rectangular shape of the utility module 200 is connected to the long side portion of the rectangular shape of the utility module 300 having substantially the same size and shape as the utility module 200 in plan view. As will be described later, the utility modules 200 and 300 supply or receive any of gas, liquid, electric power, and signals to the main modules 100A to 100T.

  The ratio of the length of the rectangular short sides to the long sides of the main modules 100A to 100T and the utility modules 200 and 300 is an integer ratio of 1: 5. Therefore, as shown in FIG. 2, in main modules 100A to 100T and utility modules 200 and 300, utility module connecting walls 102 of short side portions such as five main modules 100P to 100T connected to each other at long side portions. Are standardized so that the combined length and the length of the long side of one utility module 200 coincide with each other.

  For example, the length of one of the long sides of the main modules 100A to 100T and the utility modules 200 and 300 is 11700 mm or less so that the sea container can be transported by the high cube container. Length is 2200 mm or less and height is 2370 mm or less. In addition, the ratio of the length of the rectangular short side and the long side of the main modules 100A to 100T and the utility modules 200 and 300 may be an integer ratio other than 1: 5. Further, the ratio of the lengths of the rectangular short sides and the long sides of the main modules 100A to 100T and the utility modules 200 and 300 is equal to the total length of the short sides of the plurality of main modules 100A to 100T. If it is not necessary to match the length of the long side portion of the utility module 200, a value other than the integer ratio may be used.

  The duct 140 and the branch pipe that communicate with the utility module connecting wall 102 of the main modules 100A to 100T and the duct 240 and the main pipe that communicate with one long side of the utility module 200 are provided at mutually determined positions. Are standardized so that they are connected to each other. The duct 240 and the like leading to the other long side portion of the utility module 200 and the ducts such as the air conditioner 361 and the exhaust fan 362 leading to the one long side portion of the utility module 300 are provided at mutually determined positions. It is standardized to be connected to each other.

  As shown in FIGS. 1 and 2, the outermost main module 100A and the main module 100T among the main modules 100A to 100T connected to each other are the outermost long sides of the main modules 100A to 100T connected to each other. A side wall 103 that maintains hermeticity is provided at the site. The space surrounded by the corridor contact wall 101, the utility module connection wall 102 and the side wall 103 of the main modules 100A to 100T is kept airtight and the cleanliness management is performed.

  Further, as shown in FIG. 2, a side wall 103 which is a partition maintaining airtightness is disposed at the boundary between the main modules 100Q and 100R connected to each other and the boundary between the main modules 100S and 100T. Moreover, the partition 104 which divides a part of space, such as one main module 100P, maintaining airtightness is arrange | positioned.

  As shown in FIG. 1, the outer space 5 has a door that can freely open and close a module unpacking chamber 7 for unpacking the main modules 100 </ b> A to 100 </ b> T and utility modules 200 and 300 carried from the outside of the module system 1. Through. A product warehouse 15 is arranged around the module unpacking chamber 7. On the opposite side of the clean corridor 6 to the side where the main modules 100A to 100T are in contact, there are a washing room 8, a cell bank room 9, changing rooms 10, 11, a toilet 12, a management room 13 and a raw material stock box 14. .

  The clean corridor 6, the washing room 8, the cell bank room 9, the changing rooms 10, 11 and the raw material storage 14 are managed for cleanliness. Thus, in FIG. 1, the shaded area is a clean room with cleanliness control, and the unshaded area has no cleanliness management. A clean room is a limited space where cleanliness management is performed, and airborne microparticles and airborne microorganisms are managed below the limited cleanliness level and supplied to the space. It means a space where the required cleanliness is maintained for materials, chemicals, and water.

  The main modules 100A to 100T are assigned, for example, each of the biopharmaceutical manufacturing processes. A clean corridor 16 and a pass room 17 are assigned to the main module 100A. A seed chamber 18 and a weighing chamber 19 are assigned to the main modules 100B and 100C. A culture room 20 is assigned to the main modules 100D to 100G, and a pass room 17 is assigned to the main modules 100D and 100G therein. The first purification chamber 21 is assigned to the main modules 100H to 100Q, and the pass room 17 is assigned to the main modules 100P and 100Q therein. A second purification chamber 22 and a dispensing chamber 23 are allocated to the main modules 100R and 100S, and a pass room 17 is allocated in a section of the dispensing chamber 23 of the main module 100S. A clean corridor 16 and a pass room 17 are assigned to the main module 100T.

  Since the side wall 103 and the partition wall 104 that partition each space of the main modules 100A to 100T while maintaining airtightness can be freely arranged, removed, and moved, the manufacturing of pharmaceuticals such as the manufacturing process of biopharmaceuticals for them, The assignment of research, test and experiment processes can be changed freely. Further, as will be described later, the main modules 100A to 100T and the utility modules 200 and 300 are movable along the floor surface of the outer space 5, so that each of the biopharmaceutical manufacturing processes can be expanded, contracted, and modified. is there.

  Hereinafter, the main modules 100A to 100T of the present embodiment will be described in detail. Since the main modules 100A to 100T have the same structure, the main module 100E will be described below as a representative. As shown in FIGS. 3 and 4, the main module 100 </ b> E houses a biopharmaceutical manufacturing facility 150. The main module 100E includes a sealing module 110, a floor module 120 and an under floor module 130, which are stacked in three tiers in the vertical direction. The sealing module 110, the floor module 120 and the underfloor module 130 are connectable and separable to each other, standardized, and partially replaceable.

  The sealing module 110 is a module that constitutes the ceiling and the ceiling and back of the main module 100E. The sealing module 110 has a sealing panel 111 whose height in the vertical direction can be changed. Having the sealing panel 111 whose height in the vertical direction can be changed means that, for example, the main module 100E replaces the sealing module 110 having the sealing panel 111 having a different height according to the required height, This means that the height of the sealing panel 111 can be changed. In addition, having the sealing panel 111 capable of changing the height in the vertical direction means, for example, the sealing panel 111 by adjusting the height of the sealing panel 111 in a state where the sealing module 110 is connected to the floor module 120. It means that the height of can be changed.

  As shown in FIG. 4, the sealing module 110 includes a duct 240 and a branch pipe 141 connected to the duct 240 and the main pipe of the utility module 200, a HEPA filter (High Efficiency Particulate Air Filter) unit, a lighting fixture, and a utility. Valves and cables are installed. In addition, the sealing module 110 has a corridor contact wall 101 and a utility module connecting wall 102 at least in the height range below the sealing panel 111. When the floor module 120 has the side wall 103 and the partition wall 104, at least the sealing panel is provided. The side wall 103 and the partition wall 104 are provided in the range of height of 111 or less.

  As shown in FIGS. 3 and 4, the floor module 120 is a module that configures a wall formed by the hallway contact wall 101 and the utility module connecting wall 102 in the main module 100 </ b> E and a floor formed by the floor panel 121. The floor module 120 is integrated with the sealing module 110 below the sealing module 110 and has a floor panel 121. For example, a biopharmaceutical manufacturing facility 150 is installed in a space between the sealing panel 111 and the floor panel 121 of the sealing module 110. To accommodate.

  The manufacturing equipment 150 is, for example, a culture tank, a wagon for a pump, a culture medium preparation tank, a column, a chromatography apparatus, a buffer preparation tank, and the like. The manufacturing facility 150 may be a single-use facility, and may or may not be fixed to the floor module 120. Also, in the manufacturing facility 150, one higher than the frame of the main module 100E is once removed and transferred separately.

  The floor module 120 may have a floor panel 121 that can change the height in the vertical direction. Having the floor panel 121 capable of changing the height in the vertical direction means, for example, that the main module 100E can replace the floor module 120 having the floor panels 121 of different heights according to the required height. This means that the height of the floor panel 121 can be changed. In addition, having the floor panel 121 that can change the height in the vertical direction means, for example, adjusting the height of the floor panel 121 in a state where the floor module 120 is connected to either the sealing module 110 or the under floor module 130. By doing this, it means that the height of the floor panel 121 can be changed.

  The height of the floor panel 121 of the floor module 120 can be changed by changing the height of the under floor module 130 from the floor surface of the outer space 5 or by changing the height of the outer space 5 from the floor surface. This may be done by connecting the floor module 130 to the floor module 120.

  For example, in addition to the biopharmaceutical manufacturing facility 150, the floor module 120 is provided with a suction port, a LAN (Local Area Network), outlets, a device drain, a drain pan, and the like. In addition, the floor module 120 has a corridor contact wall 101 and a utility module connection wall 102 in a range of height at least the floor panel 121 or more. Further, when the main module 100E is disposed on the outermost side of the main modules 100A to 100T connected to each other, the floor module 120 is located on the outermost long side of the main modules 100A to 100T connected to each other. The side wall 103 which keeps airtightness in the range of height of the floor panel 121 or more at least. Further, the floor module 120 is hermetically sealed at the boundary between the main modules 100A to 100T connected to each other in the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120. It is possible to select the state in which the side wall 103 which is a partition maintaining the property is disposed and the state in which it is not disposed.

  The state in which the side wall 103 is disposed and the state in which the side wall 103 is not disposed can be freely selected. The main module 100E includes the sealing module 110 and the floor module 120 having the side wall 103, and the sealing module 110 and the floor module having no side wall 103. By exchanging with 120, it means that the state in which the side wall 103 is disposed and the state in which the sidewall 103 is not disposed can be selected. In addition, the state in which the side wall 103 is arranged and the state in which the side wall 103 is not arranged can be freely selected is that the main module 100E is in a state where the floor module 120 is connected to either the sealing module 110 or the under floor module 130. By installing or removing the side wall 103, it means that the state in which the side wall 103 is arranged and the state in which the side wall 103 is not arranged can be selected.

  Further, the floor module 120 is provided with a partition wall 104 that partitions a part of the space between the sealing panel 111 of the sealing module 110 of one main module 100E and the floor panel 121 of the floor module 120 while maintaining airtightness. A state and a state where it is not arranged can be selected freely. The state in which the partition 104 is disposed and the state in which the partition 104 is not disposed is selectable. The main module 100E includes the sealing module 110 and the floor module 120 having the partition 104, and the sealing module 110 and the floor module having no partition 104. By exchanging with 120, it means that the state in which the partition wall 104 is disposed and the state in which the partition wall 104 is not disposed can be selected. The state in which the partition 104 is disposed and the state in which the partition 104 is not disposed can be freely selected. The main module 100E is a state in which the floor module 120 is connected to either the sealing module 110 or the underfloor module 130. By installing or removing the partition wall 104, it is possible to select a state in which the partition wall 104 is disposed and a state in which the partition wall 104 is not disposed.

  The under floor module 130 is a module that constitutes an underfloor space in the main module 100E. As shown in FIG. 4, FIG. 5A and FIG. 5B, the under floor module 130 is integrated with the floor module 120 below the floor module 120, and along the floor surface of the outer space 5 on the lower surface thereof. It has the attachment recessed part 131 to which the moving part 400 to move is attached.

  As shown in FIG. 5 (A), the moving part 400 is a small hole provided in the outer wall of the air introducing part 401 into which compressed air is introduced from the outside and the compressed air introduced by the air introducing part 401 while expanding. And an air cushion part 402 for jetting compressed air to the lower surface of the moving part 400. As shown in FIG. 5A, in a state where compressed air is not supplied to the air introduction part 401, the air cushion part 402 is contracted and the under floor module 130 is landed on the floor surface. As shown in FIG. 5B, in a state where compressed air is supplied to the air introduction portion 401, the air cushion portion 402 swells and the air cushion portion 402 is filled with compressed air. Compressed air is ejected from the small holes in the outer wall of the air cushion portion 402, and leaks to the outside while forming a thin air film which is a slight gap between the air cushion portion 402 and the floor surface.

  For this reason, the under floor module 130 can be moved along the floor surface of the outer space 5 by human power in a state where the floor module 120 with the manufacturing equipment 150 installed on the floor panel 121 and the sealing module 110 are connected. It is. In addition, the moving part 400 is detachable to the attachment recessed part 131 of the under-floor module 130 of the main module 100E. Therefore, the moving unit 400 does not need to be permanently attached to the mounting recess 131 of the underfloor module 130 of the main module 100E, and only when the main module 100E is moved, the underfloor module 130 of the main module 100E is moved. The mounting recess 131 may be temporarily attached. The moving unit 400 may be moved by wheels or the like. In addition, the moving unit 400 may be movable along the floor surface of the outer space 5 by an electric motor, an internal combustion engine, or the like regardless of human power.

  As shown in FIG. 4, the underfloor module 130 is provided with a drain pipe 132, a vent pipe, and the like. The under floor module 130 does not have the corridor contact wall 101, the utility module connection wall 102 and the side wall 103, and is composed only of a frame for supporting the floor module 120. Therefore, the under floor module 130 is exposed to a space such as the outer space 5 and is disposed in a space where cleanliness management is not performed. In addition, the under floor module 130 may be comprised only with the frame in which the drainage pipe 132, the ventilation pipe, etc. are not installed. In this case, necessary piping may be installed in the floor module 120.

Note that either the sealing module 110 and the floor module 120 or the floor module 120 and the underfloor module 130 are constantly integrated, and the main module 100E can be separated only in two stages in the vertical direction. Good.
In addition, the main module 100E may be constantly integrated as a whole and can not be separated. Alternatively, any one of the sealing module 110, the floor module 120, and the under floor module 130 may be further divided in the vertical direction, and the main module 100E may be separable into four or more stages in the vertical direction.

  The main modules 100A to 100T can be connected to or separated from other main modules 100A to 100T or utility modules 200 and 300, respectively. The main modules 100A to 100T can maintain the airtightness of the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T and the floor panel 121 of the floor module 120 connected to each other.

  Further, the main modules 100A to 100T can maintain the airtightness of the space defined by the sealing panel 111, the floor panel 121, the side wall 103, and the partition wall 104 in the main modules 100A to 100T connected to each other. After the sealing panel 111, the floor panel 121, the side wall 103 and the partition wall 104 of the main modules 100A to 100T connected to each other are arranged at arbitrary positions, for example, at the joint of the sealing panel 111, the floor panel 121, the side wall 103 and the partition wall 104 Airtightness is ensured by filling the sealing material. In the corridor contact wall 101 connected via the clean corridor 6 and the clean corridor 16 or the pass room 17 of the main modules 100A to 100T, hatches, doors, etc. are installed as necessary.

  As shown in FIGS. 6A and 6B, the connection positions of the duct 140, the branch pipe 141 and the drain pipe 132 of the main module 100E and the duct 240 and the main pipe 241 of the utility module 200 are standardized. There is. For example, even when there is no piping or the like to be connected to the main module 100E side, the duct 240 and the main piping 241 of the utility module 200 are disposed. Connection of the duct 140, the branch pipe 141, the drain pipe 132, the ventilation pipe, and the like of the main module 100E and the duct 240 and the main pipe 241 of the utility module 200 is performed by the connecting flexible pipe 500 for adjusting the installation error as necessary. It is done. The main pipe 241 of the utility module 200 is disposed at a lower position than the drain pipe 132 of the main module 100E.

  Hereinafter, the utility modules 200 and 300 of this embodiment will be described in detail. The utility modules 200 and 300 are utility units 210 and 310 that perform any one of supply and reception of gas, liquid, electric power, and signals to the main modules 100A to 100T moving along the floor surface of the outer space 5. And a moving unit 400 for moving the utility unit along the floor of the outer space 5. The utility modules 200 and 300 are exposed to a space such as the outer space 5 and are arranged in an area where cleanliness management is not performed.

  Further, in the present embodiment, it is divided into a utility module 200 which is a first utility module and a utility module 300 which is a second utility module. The utility module 200 and the utility module 300 can be connected and separated with each other.

  A utility module 200 that is a first utility module is a utility unit 210, and moves a route portion that is a route of any of gas, liquid, electric power, and a signal along the floor surface of the outer space 5. The moving part 400 is provided. The utility module 300, which is the second utility module, is a utility unit 310, and includes a mechanical unit that is one of a supply source and a reception destination of gas, liquid, electric power, and a signal, and a supply / reception destination portion. And a moving unit 400 configured to move along the floor surface of the space 5.

  In connection with the main modules 100A to 100T, the utility module 300 which is the second utility module is arranged closer to the outer space 5 than the utility module 200 which is the first utility module.

  As shown in FIGS. 2 and 6A, the utility module 200 receives gas, liquid, electric power and signals for the main modules 100A to 100T moving along the floor of the outer space 5 while accommodating the manufacturing facility 150. The duct 240 and the main pipe 241 that are the path section and the utility section 210, and the duct 240 and the main pipe 241 that are the path section and the utility section 210 along the floor surface of the outer space 5. And a mounting recess 231 to which the moving unit 400 to be moved is attached. The duct 240, the main pipe 241 and the like are unitized and integrated with the utility module 200, are carried into the outer space 5 together with the utility module 200, and are connected to the main modules 100A to 100T. As shown in FIG. 2, the duct 240 of the utility module and the main pipe 241 may be connected to the utility connection pipe 600 of the permanent installation of the module system 1.

  As shown in FIG. 7, the utility module 300 receives gas, liquid, power and signals for the main modules 100A to 100T moving along the floor of the outer space 5 while accommodating the manufacturing facility 150 via the utility module 200. The air conditioner 361, the exhaust fan 362, the production power panel 363, the automatic control panel 364, etc., which is the mechanical unit which is any of the supply source and the receiving destination and the utility unit 310, and the mechanical unit is the utility unit. And a mounting recess 331 to which a moving unit 400 for moving the air conditioner 361 or the like 310 along the floor surface of the outer space 5 is attached. The cable connection of the production power panel 363 and the like is simplified by cable connection or the like.

  Note that the utility module 200 that is the first utility module and the utility module 300 that is the second utility module do not necessarily need to be connectable and separable from each other, and may be constantly integrated. .

  Further, similarly to the main modules 100A to 100T, also in the utility modules 200 and 300, the moving unit 400 is detachably attachable to the attachment recesses 231 and 331 of the utility modules 200 and 300. Therefore, the moving unit 400 does not have to be permanently attached to the mounting recesses 231 and 331 of the utility modules 200 and 300, but only when the utility modules 200 and 300 move. 231 and 331 may be temporarily attached.

  Further, in the present embodiment, the size and the shape of the utility modules 200 and 300 correspond to the size and the shape of the main modules 100A to 100T so that the high cube container can transport the marine container. However, the size and shape of the utility modules 200 and 300 may be different sizes and shapes that do not necessarily correspond to the main modules 100A to 100T.

  As shown in FIG. 8, the clean corridor 6 connected to the corridor contact walls 101 of the main modules 100A to 100T has an outer space 5 corresponding to the size and shape of the corridor contact walls 101 of the main modules 100A to 100T. A frame 62 having an opening 63 that is open is installed. The opening 63 of the frame 62 connected to the corridor contact wall 101 of the main modules 100A to 100T is closed by the corridor contact wall 101. The opening 63 of the frame 62 not connected to the corridor contact wall 101 of the main modules 100A to 100T is closed by the panel 64. In accordance with the height of the floor panel 121 of the main modules 100A to 100T, the floor 61 of the clean hallway 6 is also raised to the same height.

  Hereinafter, vertical and horizontal enlargement, reduction, and modification of a pharmaceutical related facility such as a space in which the manufacturing facility 150 according to the present embodiment is accommodated will be described. As shown in FIG. 9A, when the main modules 100A to 100E connected to each other are arranged, the utility module 300 is disconnected from the utility module 200 and moved on the floor surface of the outer space 5. .

  In the operation described below, when the space for moving the main modules 100A to 100E and the utility modules 200 and 300 in the outer space 5 is insufficient, the main module 100A is removed by appropriately removing the outer wall 2. The space for moving ~ 100E and the utility modules 200 and 300 can be supplemented.

  As shown in FIG. 9B, the utility module 200 is disconnected from the main modules 100A to 100E, and the floor surface of the outer space 5 is moved. The floor surface of the outer space 5 may be moved by releasing the connection with the main modules 100A to 100E while the utility module 200 and the utility module 300 are integrated without being separated.

  As shown in FIG. 9C, the main module 100D of the main modules 100A to 100E connected to each other is released from the connection with the main module 100C, and the main module 100D, 100E is further displaced to the outside. You can move the plane. Thus, a gap for inserting a new main module 100X as shown in FIG. 9D is formed between the main modules 100C and 100D.

  As shown in FIG. 9D, the new main module X unpacked in the module unpacking chamber 7 is moved on the floor surface of the outer space 5 and inserted between the main modules 100D and 100E. It is connected to 100D and 100E. Also, utility modules 200 and 300 for the new main module X are prepared. As shown in FIG. 9E, the utility module 200 is connected to the main modules 100A to 100E and 100X, and the utility module 300 is connected to the utility module 200. Thereby, the expansion | extension to the horizontal direction of pharmaceutical related facilities, such as the space where the manufacturing equipment 150 is accommodated, is performed.

  The height of the sealing panel 111 of the sealing modules 110 of the main modules 100A to 100E and 100X is changed as appropriate. Further, the arrangement of the side wall 103 and the partition wall 104 of the sealing module 110 of the main modules 100A to 100E and 100X is appropriately changed. As a result, vertical and horizontal enlargement, reduction, and modification of pharmaceutical-related facilities, such as a space in which the manufacturing facility 150 is accommodated, are performed.

  On the other hand, when the horizontal reduction of the pharmaceutical-related facilities such as the space in which the manufacturing equipment 150 is accommodated, after operations similar to those in FIGS. 9 (A) to 9 (B) are performed, For example, the main module 100C is disconnected from the main modules 100B and 100D, and the floor surface of the outer space 5 is moved. The main module 100B and the main module 100D are brought close to each other so as to fill a gap between the main modules 100B and 100D, and the main module 100B and the main module 100D are connected. Thereby, the reduction of the pharmaceutical related facilities such as the space where the manufacturing facility 150 is accommodated is performed in the horizontal direction.

  Also, as shown in FIGS. 10 (A) to 10 (B), after the same operation as in FIGS. 9 (A) to 9 (B) is performed, as shown in FIG. 10 (C), the main module 100C. May release the connection with the main modules 100B and 100D and move the floor surface of the outer shell space 5 to the module unpacking chamber 7 or the like. As shown in FIG. 10D, the main module 100Y is provided between the main modules 100B and 100D with a partition 104 for dividing a space in which the manufacturing facility 150 is accommodated in a direction parallel to the long side of the main module 100Y. It is inserted, connected to the main modules 100B and 100D, and replaced with the main module 100C. As shown in FIGS. 10E and 10F, the utility modules 200 and 300 are connected again. Thereby, by adding the partition by the partition wall 104, the modification of the facility related to the pharmaceutical such as the space in which the manufacturing facility 150 is accommodated, or the change of the process of manufacturing, research, testing and experiment of the pharmaceutical such as the biopharmaceutical is performed. .

  11A, the main module 100C of FIG. 10C is removed from between the main modules 100B and 100D, and the main module 100C of the main modules 100B and 100D is removed. The side wall 103 may be added to the long side of the utility modules 200 and 300, and the utility modules 200 and 300 may be connected again. That is, the main modules 100A to 100T may not necessarily be disposed in close proximity.

  11B, the corridor contact wall 101, the utility module connecting wall 102 and the side wall 103 of the main module 100A, the corridor contact wall 101 and the utility module connecting wall 102 of the main module 100B, and the inner wall of the building. 3, the corridor contact wall 101 and the utility module connecting wall 102 of the main modules 100C and 100D, the corridor contact wall 101, the utility module connecting wall 102 and the side wall 103 of the main module 100E, and the inner wall 3 of the building. The space partitioned by and may form a pharmaceutical related facility such as a space in which the manufacturing facility 150 is accommodated. That is, not only the main modules 100A to 100T but also the inner wall 3 of the building may form a space for accommodating the manufacturing facility 150.

  Further, as shown in FIG. 11C, the outer space 5 surrounded by the outer wall 2 of the building is divided into two or more sections by the inner wall 3 of the building, and the main modules 100A to 100T are divided into the respective sections. A pharmaceutical-related facility such as a space in which the manufacturing facility 150 is accommodated may be formed. In the movement of the main modules 100A to 100T and the utility modules 200 and 300, the movement may be performed for each module unit 1000 in which the main modules 100A to 100T and the utility modules 200 and 300 are connected.

  According to the present embodiment, in the main modules 100A to 100T accommodating the manufacturing facility 150, in the sealing module 110, the height in the vertical direction of the sealing panel 111 can be changed, and the sealing module 110 and the sealing module 110 are In the floor module 120 which is integrated and has the floor panel 121, the height of the space for accommodating the manufacturing facility 150 can be increased to accommodate the manufacturing facility 150 in the space between the sealing panel 111 of the sealing module 110 and the floor panel 121. Can be changed. The under floor module 130 integrated with the floor module 120 below the floor module 120 is moved along the floor surface by the moving unit 400, and the main modules 100A to 100T are connected to the other main modules 100A to 100T. The space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120 can be maintained. Accordingly, the space in which the manufacturing facility 150 is accommodated can be freely expanded, reduced, and modified in the vertical direction and the horizontal direction, and the degree of freedom in pharmaceutical-related facilities can be improved. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be freely expanded, reduced, and modified in the vertical direction and the horizontal direction according to the situation of production of biopharmaceuticals, and the use in the production of biopharmaceuticals etc. The degree of freedom can be improved.

  Further, according to the present embodiment, in the space between the sealing panel 111 of the sealing module 110 of the main modules 100A to 100T connected to each other and the floor panel 121 of the floor module 120, the boundaries of the main modules 100A to 100T connected to each other. The side wall 103, which is a partition wall that keeps airtightness, can be selected between the state in which the side wall 103 is disposed and the state in which the side wall 103 is not disposed. It can be partitioned, and it can further improve the degree of freedom in pharmaceutical related facilities. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be freely partitioned according to the situation of production of biopharmaceuticals etc., and the degree of freedom of use in production of biopharmaceuticals etc. can be further improved. .

  In addition, according to the present embodiment, the partition wall 104 that partitions a part of the space between the sealing panel 111 of the sealing module 110 such as one main module 100E and the floor panel 121 of the floor module 120 while maintaining airtightness. Since the arrangement state and the non-arrangement state can be freely selected, the space in which the manufacturing equipment 150 is accommodated can be finely divided according to the situation of the pharmaceutical-related facility, and the freedom in the pharmaceutical-related facility is free. The degree can be further improved. In the present embodiment, the space in which the manufacturing facility 150 is accommodated can be finely divided according to the situation of production of biopharmaceuticals and the like, and the degree of freedom of use in production of biopharmaceuticals and the like can be further improved.

  In addition, according to the present embodiment, supply or reception of any of gas, liquid, power, and signal is performed with respect to the main modules 100A to 100T that move along the floor surface of the outer space 5 while housing the manufacturing facility 150. In the utility modules 200 and 300 having the main pipe / duct 240, which is a utility section for performing any of the above, and the air conditioner 361, etc., the main pipe / duct 240, the air conditioner 361, etc., which are utility sections, are moved to the floor by the moving section 400. Since the main modules 100A to 100T can be moved along, the degree of freedom of the path for supplying gas or the like to the main modules 100A to 100T can be improved, and the degree of freedom in medical-related facilities can be improved. In the present embodiment, it is possible to improve the degree of freedom of use in the manufacture of biopharmaceuticals and the like.

  Moreover, since the utility modules 200 and 300 are exposed to a space such as the outer space 5 and are disposed in an area where the cleanliness management is not performed, the utility modules 200 and 300 are managed, maintained, and maintained. Is easy. In addition, in the connection with the main modules 100A to 100T, the utility module 300, which is the second utility module, is arranged so as to be located closer to the outer space 5 than the utility module 200, which is the first utility module. While maintaining the connection between the utility module 200 and the main modules 100A to 100T, separate the utility module 300 having a mechanical part that requires maintenance from the utility module 200 having a path part that requires little maintenance, The utility module 300 can be easily managed, maintained, and maintained.

  As mentioned above, although embodiment of this invention was described, this invention is implemented in various forms, without being limited to the said embodiment. For example, the main modules 100A to 100T do not necessarily have to accommodate the manufacturing facility 150, and may be applied to applications other than manufacturing. The manufacturing facility 150 contained in the main modules 100A to 100T is not limited to the application for the production of biopharmaceuticals, and may be applied to the application of production, research, testing and experiments for other pharmaceuticals capable of maintaining airtightness. it can.

  Also, the main modules 100A to 100T and the utility modules 200 and 300 may be divisible, for example, in the direction of the long side. For example, in the situation shown in FIG. 9E, the utility module 200 divided into 1⁄5 of the length in the direction of the long side may be connected to the main module 100E. In the situation shown in FIG. 9F, the utility module 200 divided into 1/5 length in the long side direction is divided into the utility module 200 divided into 1/5 length in the long side direction. 300 may be connected. As a result, even when the main modules 100A to 100T whose number is a multiple of 5 are connected, the length of the utility modules connecting walls 102 of the short sides of the main modules 100A to 100T connected to each other and the utility modules 200 and 300 The total length of the long sides can be matched.

  Also, as shown in FIG. 12, for example, the module unit 1000 of the present embodiment includes a main module 100α having a ratio of lengths of short sides and long sides of a rectangular shape in a plan view and an integer ratio of 1: 3. The utility modules 200α and 300α may be composed of the main module 100β and the utility modules 200β and 300β in which the ratio of the length of the rectangular short side to the long side in the plan view is an integer ratio of 1: 2. . For example, in the module unit 1000 of the present embodiment, the short side and the long side of each of the main modules 100α and 100β may be connected to each other. Further, the short sides of the main modules 100α and 100β and the short sides of the utility modules 200α, 200β, 300α, and 300β may be connected to each other.

  Further, as shown in FIG. 13A, the main modules 100α and 100β may not have the side wall 103. Further, as shown in FIG. 13B, the main modules 100α and 100β may have the side wall 103 only on the long side. Further, as shown in FIG. 13C, the main modules 100α and 100β may have the side wall 103 only on the short side. Further, as shown in FIG. 13D, the main modules 100α and 100β may have sidewalls 103 on the short side and the long side. 13E, the main modules 100α and 100β may have side walls 103 on the short side and the long side, and a space partitioned by the side walls may be further partitioned by a partition wall 104.

  DESCRIPTION OF SYMBOLS 1 ... Module system, 2 ... Outer wall, 3 ... Inner wall, 4 ... Machine room, 5 ... Outer space, 6 ... Clean corridor, 7 ... Module unpacking room, 8 ... Cleaning room, 9 ... Cell bank room, 10, 11 ... Changing clothes Room, 12 ... toilet, 13 ... management room, 14 ... raw material stock, 15 ... product warehouse, 16 ... clean corridor, 17 ... pass room, 18 ... seed room, 19 ... weighing room, 20 ... culture room, 21st 1 purification chamber, 22 ... second purification chamber, 23 ... dispensing chamber, 61 ... floor, 62 ... frame, 63 ... opening, 64 ... panel, 100A to 100T, 100X, 100Y ... main module, 100α, 100β ... main Module, 101 ... Corridor contact wall, 102 ... Utility module connection wall, 103 ... Side wall, 104 ... Partition, 110 ... Sealing module, 111 ... Sealing panel, 120 ... Floor Module, 121 ... Floor panel, 130 ... Under floor module, 131 ... Mounting recess, 132 ... Drain pipe, 140 ... Duct, 141 ... Branch pipe, 150 ... Manufacturing equipment, 200 ... Utility module, 200α, 200β ... Utility module, 210 ... Utility part, 231 ... Mounting recess, 240 ... Duct, 241 ... Main piping, 300 ... Utility module, 300α, 300β ... Utility module, 310 ... Utility part, 331 ... Mounting recess, 361 ... Air conditioner, 362 ... Exhaust fan, 363: Production power panel, 364: Automatic control panel, 400: Moving section, 401: Air introducing section, 402: Air cushion section, 500: Flexible pipe for connection, 600: Utility connection piping, 1000: Module unit.

Claims (8)

A sealing module having a sealing panel whose height in the vertical direction can be changed;
A floor module integrated with the sealing module below the sealing module and having a floor panel;
An under-floor module integrated with the floor module below the floor module and having a moving unit moving along the floor surface;
A main module with
A main module that is connected to the other main modules and that can maintain airtightness of the space between the sealing panel of the sealing module of the main module and the floor panel of the floor module that are connected to each other.   In a space between the sealing panel of the sealing module and the floor panel of the floor module of the main module connected to each other, a state and an arrangement in which an airtight partition wall is arranged at a boundary of the main modules connected to each other The main module according to claim 1, wherein the main module is freely selectable.   A state in which a partition that partitions a part of a space between the sealing panel of the sealing module of the main module and the floor panel of the floor module while maintaining airtightness is disposed and a state in which a partition is not disposed The main module according to claim 1 or 2, which is selectable. A utility unit that performs any one of supply and reception of gas, liquid, power, and signal to the main module according to any one of claims 1 to 3 ,
A moving unit for moving the utility unit along the floor surface. A utility unit for supplying or receiving any of gas, liquid, power and signal to the main module moving along the floor;
A moving unit for moving the utility unit along the floor surface;
With
The utility module , wherein the moving unit is detachable from the utility unit .   A utility unit for supplying or receiving any of gas, liquid, power and signal to the main module moving along the floor;
  A moving part for moving the utility part along the floor;
Equipped with
  A utility module connectable with and detachable from the main module. The module unit provided with the main module of any one of Claims 1-3, and the utility module of any one of Claims 4-6. A module system comprising the module unit according to claim 7 in an outer space partitioned from the outside.

Images