WO2019124565A1 - Synergistic bactericide composition including nitrophenol compound and bactericidally active compound - Google Patents

Synergistic bactericide composition including nitrophenol compound and bactericidally active compound Download PDF

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Publication number
WO2019124565A1
WO2019124565A1 PCT/JP2018/047403 JP2018047403W WO2019124565A1 WO 2019124565 A1 WO2019124565 A1 WO 2019124565A1 JP 2018047403 W JP2018047403 W JP 2018047403W WO 2019124565 A1 WO2019124565 A1 WO 2019124565A1
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Prior art keywords
compound
inhibitor
group
nitrophenol
bactericidal
Prior art date
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PCT/JP2018/047403
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French (fr)
Japanese (ja)
Inventor
悟 常岡
義紀 山本
直孝 林
Original Assignee
Ｏａｔアグリオ株式会社
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Application filed by Ｏａｔアグリオ株式会社 filed Critical Ｏａｔアグリオ株式会社
Priority to KR1020207021579A priority Critical patent/KR20200104359A/en
Priority to JP2019560607A priority patent/JP7029186B2/en
Publication of WO2019124565A1 publication Critical patent/WO2019124565A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
    • A01N33/18—Nitro compounds
    • A01N33/20—Nitro compounds containing oxygen or sulfur attached to the carbon skeleton containing the nitro group
    • A01N33/22—Nitro compounds containing oxygen or sulfur attached to the carbon skeleton containing the nitro group having at least one oxygen or sulfur atom and at least one nitro group directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
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    • A01N37/34—Nitriles
    • A—HUMAN NECESSITIES
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    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
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Definitions

  • the present invention relates to a synergistic germicidal composition
  • a synergistic germicidal composition comprising a nitrophenol compound and a germicidally active compound.
  • bactericidal composition in which the bactericidal activity is improved by a synergistic effect by combining two or more existing bactericidally active compounds (Patent Document 1).
  • nitrophenol compounds are disclosed to have a plant growth promoting effect (Patent Document 2) and a BT toxin (insecticidal protein) production promoting effect (Patent Document 3), but nitrophenol is a bactericidal agent. There is no description or suggestion that it is an activity enhancer.
  • An object of the present invention is to provide a synergistic bactericidal composition having an even better control effect against agricultural and horticultural pathogens.
  • the present invention relates to a synergistic germicidal composition and the like comprising the following nitrophenol compound and a germicidally active compound.
  • a synergistic germicidal composition comprising (A) a nitrophenol compound and (B) a germicidally active compound.
  • Item 2. (B) a bactericidal compound is (B1) RNA polymerase inhibitor (A1), (B2) ⁇ -tubulin polymerization inhibitor (B1, 2, 3), (B3) Delocalizer for spectrin-like protein (B5), (B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2), (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3), (B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4), (B7) uncoupling agent (C5) in oxidative phosphorylation (B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8), (B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2), (B10) Cell membrane
  • a bactericidal compound is (B1) RNA polymerase inhibitor (A1), (B2) ⁇ -tubulin polymerization inhibitor (B3), (B3) Delocalizer for spectrin-like protein (B5), (B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2), (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3), (B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4), (B7) uncoupling agent (C5) in oxidative phosphorylation (B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8), (B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2), (B10) Cell membrane permeable fatty acid (F4), (B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2), (B10) Cell membrane permeable fatty acid
  • a bactericidal compound is (B1) RNA polymerase inhibitor (A1), (B2) ⁇ -tubulin polymerization inhibitor (B3), (B3) Delocalizer for spectrin-like protein (B5), (B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2), (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3), (B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4), (B7) uncoupling agent (C5) in oxidative phosphorylation (B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8), (B10) Cell membrane permeable fatty acid (F4), (B11) lipid homeostasis, metastasis, storage inhibitor (F9), (
  • RNA polymerase inhibitor (A1) is an acyl alanine compound
  • B2) ⁇ -tubulin polymerization inhibitor (B3) is an ethylaminothiazole carboxamide compound
  • B3 The delocalizing agent for spectrin-like protein (B5) is a pyridinyl methyl benzamide compound
  • B4 a respiratory chain complex II (succinic acid dehydrogenase) inhibitor
  • C2 is a pyridine carboxamide compound
  • Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3) is a methoxycarbamate compound, a methoxyacrylate compound, and an oximinoacetic acid compound, an oxazolidinedione compound
  • B6 Respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4) is a cyanoimidazole compound
  • B7 The uncoupling agent (C5) in oxidative
  • the bactericidally active compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cyazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxys Poconazole fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetyl aluminum, phosphorous acid or salts thereof, oxathiapiproline, nonylphenol sulfonic acid
  • Item 7. The synergistic germicidal composition according to any one of Items 1 to 6, wherein the (A) nitrophenol compound is a phenol compound having one nitro group.
  • Item 8. The synergistic germicidal composition according to any one of Items 1 to 7, wherein the blending ratio of (A) the nitrophenol compound is 1 to 5000 parts by weight with respect to 100 parts by weight of (B) the bactericidal active ingredient .
  • Item 9. Item 9.
  • a method for controlling a pathogen which comprises treating the synergistic microbicidal composition according to any one of items 1 to 8 in a habitat (except for humans) of agricultural and horticultural pathogens.
  • Item 10. Item 9.
  • a method for controlling pathogens which comprises treating the synergistic germicidal composition according to any one of items 1 to 8 in the habitat of agricultural and horticultural pathogens.
  • Item 9. A plant protection method comprising treating the synergistic bactericidal composition according to any one of items 1 to 8 to a plant parasitic to agricultural and horticultural pathogens or its vicinity.
  • Item 12. Method of using a nitrophenol compound for enhancing bactericidal activity.
  • the bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, spywareofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetylaluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt And at least one compound selected from the group consisting of and simoxanyl.
  • Item 14. The method according to item 12 or 13, wherein the nitrophenol compound is a phenol compound having one nitro group.
  • Item 15. A bactericidal activity enhancer containing a nitrophenol compound.
  • Item 16. It is a bactericidal activity enhancer containing a nitrophenol compound for a bactericidally active compound,
  • the bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, spywareofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride
  • the synergistic germicidal composition of the present invention is effective against agricultural and horticultural pathogens at low doses.
  • the synergistic bactericidal composition of the present invention exerts similarly excellent control effects even on agricultural and horticultural pathogens that have acquired resistance to existing bactericidal compounds.
  • the treatment dose can be reduced as compared with the case where each existing bactericidal agent is used alone, the agricultural and horticultural pathogens for each bactericidal compound can be reduced. It can also suppress the development of resistance.
  • synergistic Bactericidal Composition A synergistic germicidal composition (hereinafter sometimes referred to as "the composition of the present invention") containing the nitrophenol compound of the present invention and a germicidally active compound is described below.
  • Nitrophenol Compound (A) The nitrophenol compound is not particularly limited as long as it is an aromatic ring compound having one or more nitro groups and one or more hydroxyl groups (OH groups). Furthermore, you may have substituents other than the said nitro group and a hydroxyl group.
  • the substituent is not particularly limited, for example, a halogen atom, C 1 ⁇ 6 alkyl group, C 1 ⁇ 6 haloalkyl group, C 1 ⁇ 6 alkoxy group, C 1 ⁇ 6 haloalkoxy group, C 2 ⁇ 6 alkenyl group , C 2 ⁇ 6 haloalkenyl groups, C 2 ⁇ 6 alkenyloxy groups, C 2 ⁇ 6 haloalkenyloxy groups, C 2 ⁇ 6 alkynyl groups, C 2 ⁇ 6 haloalkynyl groups, C 2 ⁇ 6 alkynyloxy groups, C etc. 2-6 haloalkynyloxy group.
  • the nitrophenol compound in the present specification also includes a salt-formed nitrophenol compound (a salt of a nitrophenol compound).
  • salts in the present specification include alkali metal salts (sodium salt, potassium salt and the like), alkaline earth metal salts (calcium salt, magnesium salt and the like), ammonium salt (ammonia; morpholine, piperidine, pyrrolidine, lower mono, Di- or trialkylamines, organic amines such as lower mono-, di- or trihydroxyalkylamines, etc., and the like, and the like, preferably water-soluble, agrochemically advantageous salts, more preferably alkali metal salts. is there.
  • nitrophenol compound for example, the following general formula (1): (Wherein, X represents a C—R ′ group or a nitrogen atom. R, and R 'are the same or different, a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, C 1 ⁇ 6 alkyl group, C 1 ⁇ 6 haloalkyl group, C 1 ⁇ 6 alkoxy group, C 1 ⁇ 6 haloalkoxy groups, C 2 ⁇ 6 alkenyl groups, C 2 ⁇ 6 haloalkenyl groups, C 2 ⁇ 6 alkenyloxy groups, C 2 ⁇ 6 haloalkenyloxy groups, C 2 ⁇ 6 alkynyl groups, C 2 ⁇ 6 haloalkynyl groups, C 2-6 alkynyloxy group, or an C 2-6 haloalkynyl group. )
  • the nitrophenol compound or its salt etc. which are represented by these are mentioned.
  • nitrophenol compound the following general formula (2): (Wherein, R 1 , R 2 , R 3 , R 4 and R 5 groups are the same or different and are a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a C 1-6 alkyl group, a C 1-6 haloalkyl groups, C 1 ⁇ 6 alkoxy groups, C 1 ⁇ 6 haloalkoxy groups, C 2 ⁇ 6 alkenyl groups, C 2 ⁇ 6 haloalkenyl groups, C 2 ⁇ 6 alkenyloxy groups, C 2 ⁇ 6 haloalkenyloxy groups, C 2-6 alkynyl group, C 2-6 haloalkynyl group, a C 2-6 alkynyloxy group, or a C 2-6 haloalkynyl group.)
  • the nitrophenol compound or its salt etc. which are represented by these are mentioned.
  • halogen atom for example, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom etc. are mentioned.
  • the C 1-6 alkyl group is not particularly limited, and examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, an s-butyl group, a t-butyl group, and n- Examples thereof include linear or branched alkyl groups having 1 to 6 carbon atoms such as pentyl group, isopentyl group, neopentyl group, n-hexyl group and isohexyl group. In the present specification, "n-" indicates normal, "s-" indicates secondary, and "t-" indicates tertiary.
  • the C 1-6 haloalkyl group is not particularly limited, and examples thereof include a fluoromethyl group, a chloromethyl group, a bromomethyl group, an iodomethyl group, a difluoromethyl group, a trifluoromethyl group, a 1-fluoroethyl group and a 2-fluoroethyl group.
  • the C 1-6 alkoxy group is not particularly limited, and examples thereof include a methoxy group, an ethoxy group, an n-propoxy group, an isopropoxy group, an n-butoxy group, an isobutoxy group, an s-butoxy group, an s-butoxy group, and an n-butoxy group.
  • C1-C6 linear or branched alkoxy groups such as pentyloxy group, isopentyloxy group, neopentyloxy group, n-hexyloxy group and isohexyloxy group.
  • the C 1-6 haloalkoxy group is not particularly limited.
  • the C 2 ⁇ 6 alkenyl group is not particularly limited, for example, vinyl group, 1-propenyl group, allyl group, isopropenyl group, 1-butenyl, 2-butenyl, 3-butenyl group, 1-methyl - And C2-C6 linear or branched alkenyl groups such as 2-propenyl group and 1,3-butadienyl group.
  • the C 2 ⁇ 6 haloalkenyl group is not particularly limited, for example, 2,2-dichlorovinyl group, 2,2-dibromo-vinyl group, 3-chloro-2-propenyl group, 3,3-difluoro-2-Allyl group, 3,3-dichloro-2-allyl group, 4-chloro-2-butenyl group, 4,4,4-trifluoro-2-butenyl group, 4,4,4-trichloro-3-butenyl group, A linear or branched alkenyl group having 2 to 6 carbon atoms having at least one double bond at any position such as 5-chloro-3-pentenyl group, 6-fluoro-2-hexenyl group, etc. And alkenyl groups substituted with 1 to 13, preferably 1 to 7 halogen atoms.
  • the 2-6 alkenyloxy group is not particularly limited, for example, vinyloxy group, 1-propenyloxy group, allyloxy group, isopropenyloxy group, 1-butenyloxy, 2-butenyloxy, 3-butenyloxy group, 1 And C2-C6 linear or branched alkenyloxy groups such as -methyl-2-propenyloxy group and 1,3-butadienyloxy group.
  • the C 2 ⁇ 6 haloalkenyloxy group is not particularly limited, for example, 2,2-dichlorovinyl group, 2,2-dibromo-vinyl group, 3-chloro-2-propenyloxy group, 3,3 Difluoro-2-allyloxy group, 3,3-dichloro-2-allyloxy group, 4-chloro-2-butenyloxy group, 4,4,4-trifluoro-2-butenyloxy group, 4,4,4-trichloro-3 —C2-C6 linear or branched chain having at least one double bond at any position such as butenyloxy group, 5-chloro-3-pentenyloxy group, 6-fluoro-2-hexenyloxy group and the like
  • the C 2 ⁇ 6 alkynyl group include an ethynyl group, 1-propynyl, 2-propynyl, 1-methyl-2-propynyl group, 1-butynyl group, 2-butynyl group, carbon atoms such as 3-butynyl group And 2 to 6 straight or branched chain alkynyl groups.
  • the 2-6 haloalkynyl group is not particularly limited, for example, 3,3,3-trifluoro-propynyl group, 3,3-difluoro-propynyl group, 3,3,3-trifluoro-butynyl group, 4, A linear or branched alkynyl group having 2 to 6 carbon atoms which has at least one triple bond at any position such as 4,4-trifluoro-2-butynyl group, 3,3-difluoro-butynyl group, etc. And an alkynyl group substituted with 1 to 13, preferably 1 to 7 halogen atoms.
  • the C 2 ⁇ 6 alkynyloxy group is not particularly limited, for example, ethynyl group, 1-propynyloxy group, 2-propynyl group, 1-methyl-2-propynyl group, 1-butynyloxy group, 2- Examples thereof include linear or branched alkynyloxy groups having 2 to 6 carbon atoms, such as butynyloxy group and 3-butynyloxy group.
  • the C 2 ⁇ 6 haloalkynyloxy group is not particularly limited, for example, 3,3,3-trifluoro-propynyl group, 3,3-difluoro-propynyloxy group, 3,3,3-trifluoro-butynyl-oxy Group, linear or branched having 2 to 6 carbon atoms having at least one triple bond at any position such as 4,4,4-trifluoro-2-butynyloxy, 3,3-difluoro-butynyloxy and the like
  • Examples of the alkynyloxy group include alkynyloxy groups substituted with 1 to 13, preferably 1 to 7 halogen atoms.
  • the aromatic ring compound is not particularly limited, and examples thereof include carbocyclic compounds such as benzene, naphthalene and anthracene; and heterocyclic compounds such as pyridine, pyrimidine, pyridazine, pyrazine and pyrazole.
  • X is preferably a C—R group.
  • R ' is a hydrogen atom, a halogen atom, is preferably from C 1 ⁇ 6 alkyl group or a C 1 ⁇ 6 alkoxy group, a hydrogen atom or a methoxy group More preferable.
  • R 1 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
  • R 2 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
  • R 3 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
  • R 4 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
  • R 5 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
  • nitrophenol compounds such as 4-nitrophenol, 4-nitrophenol sodium salt, 3-nitrophenol, 3-nitrophenol sodium salt, 2-nitrophenol, 2-nitrophenol sodium salt or salts thereof;
  • Particularly preferred are guaiacol (alias: guaiacol) compounds such as nitroguaiacol, 5-nitroguaiacol sodium salt, 4-nitroguaiacol, 4-nitroguaiacol sodium salt and the like or salts thereof.
  • the nitrophenol compound contained in the composition of the present invention is a known compound, and a commercially available product (Atonic (registered trademark)) or a compound produced by a known production method can be used.
  • the manufacturing method thereof is described, for example, in JP-A-10-67716.
  • the above atomic is an aqueous solution containing 4-nitrophenol (0.3%), 2-nitrophenol (0.2%) and 5-nitroguaiacol (0.1%).
  • the fungicidal compound contained in the composition of the present invention is not particularly limited as long as it is a compound known as a compound having a controlling effect on agricultural pests.
  • the composition of the present invention exerts the effects of the present invention, other pesticides, acaricides and fungicides can be appropriately used in combination as a pesticide.
  • the bactericidal active compound is not particularly limited, and, for example, A (nucleic acid synthesis), B (in the action classification by FRAC (Fungicide Resistance Action Committee) Mitotic division and cell division), C (respiration), D (amino acid and protein biosynthesis), E (signal transduction), F (lipid biosynthesis or transport / cell membrane structure or function), G (cell membrane sterol biosynthesis) ), H (cell wall biosynthesis), I (melanin biosynthesis of cell wall), P (resistance growth induction of host plant), M (multifunctional contact compound), U (action mechanism unknown), compounds not classified Etc.
  • A nucleic acid synthesis
  • B in the action classification by FRAC (Fungicide Resistance Action Committee) Mitotic division and cell division
  • C respiration
  • D amino acid and protein biosynthesis
  • E signal transduction
  • F lipid biosynthesis or transport / cell membrane structure or function
  • G cell membrane sterol biosynthesis
  • H cell wall biosynthesis
  • I melting induction of host plant
  • M multi
  • group A group A, group B, group C, group F, group G, group H, group M and group U are preferable, and the following group (A1), group (B1, 2, 3, B5), group (C2, C3, C4, C5, C8), group (F4, F9), group (G1), group (H5), group (M1, 3, 5), and group (U) are more preferable.
  • RNA polymerase inhibitor A1
  • A2 adenosine deaminase
  • A3 DNA / RNA biosynthesis inhibitor
  • DNA topoisomerase A4
  • RNA polymerase inhibitors include, for example, acylalanines such as benalaxyl (benalaxyl), benalaxyl M (benalaxyl-M), furalaxyl (furalaxyl), metalaxyl (metalaxyl), metalaxyl M (metalaxyl-M), etc. ofurace etc. Butyrolactones; oxazolidinones such as oxadixyl; and the like.
  • Adenosine deaminase (A2) Examples of adenosine deaminase include hydroxy (2-amino-) pyrimidines such as bupirimate, dimethirimol, ethirimol and the like.
  • DNA / RNA biosynthesis inhibitor examples include isoxazoles such as hymexazole and isothiazolones such as octhilinone.
  • DNA topoisomerase examples include carboxylic acids such as oxolinic acid, and the like.
  • ⁇ B group> As group B (mitotic division and cell division), for example, ⁇ -tubulin polymerization inhibitor (B1, 2, 3), cell division inhibitor (B4), delocalizing agent of spectrin-like protein (B5) ), Inhibitors of actin, myosin and fimbrin functions such as vesicle transport (B6) and the like.
  • ⁇ -tubulin polymerization inhibitor (B1)
  • ⁇ -tubulin polymerization inhibitors include benzamyls such as benomyl, fuberidazole, carbendazim, thiabendazole, etc .; thiophanate, thiophanate methyl, etc. And thiophanates of
  • ⁇ -tubulin polymerization inhibitor B2
  • N-phenyl carbamates such as diethofencarb.
  • ⁇ -tubulin polymerization inhibitor examples include toluamides such as zoxamide; ethylaminothiazole carboxamides such as ethaboxam; and the like.
  • Cell division inhibitor (B4) examples include phenylureas such as pencycuron and the like.
  • Delocalization agent of spectrin-like protein (B5)
  • Examples of the delocalization agent for spectrin-like protein include pyridinylmethyl benzamides such as fluopicolide, and the like.
  • Inhibitors of actin, myosin and fimbrin functions such as vesicle transport (B6)
  • Examples of inhibitors of actin, myosin and fimbrin functions such as vesicle transport include aminocyanoacrylates such as phenamacril; benzophenones such as metrafenone; benzoylpyridines such as pyriofenone Can be mentioned.
  • ⁇ C group> As group C (respiratory), for example, respiratory chain complex I (NADH oxidase) inhibitor (C1), respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2), respiratory chain complex III (ubiquinol) Oxidase, Qo site) inhibitor (C3), respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4), uncoupling agent in oxidative phosphorylation (C5), inhibition of oxidative phosphorylation in ATP synthesis
  • the agent (C6), the ATP production inhibitor (C7), the respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8) and the like can be mentioned.
  • Respiratory chain complex I (NADH oxidase) inhibitor C1
  • respiratory chain complex I (NADH oxidase) inhibitors include pyrimidine amines such as diflumetrim; pyrazole carboxamides such as tolfenpyrad; quinazolines such as fenazaquin; and the like.
  • Respiratory chain complex II succinic acid dehydrogenase inhibitor (C2)
  • respiratory chain complex II (succinate dehydrogenase) inhibitors include phenylbenzamides such as benodanil, flutolanil, mepronil and the like; phenyloxoethylthiophene amides such as isofetamide and the like Pyridinylethyl benzamides such as fluopyram; furancarboxamides such as fenfuram; oxathiin carboxamides such as carboxin, oxicarboxin etc .; thifluzamide etc Thiazolecarboxamides; benzobindiflupyr (benzovindiflupyr), bixafen (bixafen), fluindapyr (fluindapyr), fluxapyroxad (fluxapyroxad), furametopyr (furametpyr), isopyrazam, penflufen, penflufen, isopyra
  • Respiratory chain complex III (Ubiquinol oxidase, Qo site) inhibitor (C3)
  • a respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor for example, azoxystrobin (azoxystrobin), picoxystrobin (picoxystrobin), enoxastrobin (enoxastrobin), pyroxystrobin (pyraoxystrobin), Methoxy acrylates such as coumoxystrobin, fluphenoxystrobin, etc .; methoxyacetamides such as mandestrobin, etc .; orysastrobin (orysastrobin), dimoxystrobin (dimoxystrobin), metominostrobin ( Metominosstrobin), oxaminamides such as phenaminstrobin (fenaminstrobin); Pyraclostrobin, pyrametostrobin, methoxycarbamates such as triclopyricarb (cresoximmeth) (Kresoxim-methyl), oxi
  • Respiratory chain complex III ubiquinone reductase, Qi site
  • a respiratory chain complex III ubiquinone reductase, Qi site
  • cyanoimidazole such as cyazofamid (cyazofamid)
  • sulfamoyltriazole such as amisulbrom
  • picolinamides such as fenpicoxamide And Ferimsone etc.
  • Uncoupling agent (C5) in oxidative phosphorylation examples include 2,6-dinitroanilines such as fluazinam; dinitrophenyl crotonic acids such as meptyl dinocap; binapacryl; ferimzone Etc.), and the like.
  • Inhibitors of oxidative phosphorylation in ATP synthesis include triphenyltin compounds such as fentin acetate, fentin chloride, fentin hydroxide and the like.
  • ATP production inhibitor examples include thiophenecarboxamides such as silthiofam and the like.
  • Respiratory chain complex III ubiquinone reductase, Qo site
  • a respiratory chain complex III ubiquinone reductase, Qo site
  • triazolopyrimidylamine such as ametoctradin and the like, and the like
  • D group amino acid and protein biosynthesis
  • D1 methionine biosynthesis inhibitor
  • D2, 3, 4, 5 protein synthesis inhibitor
  • Methionine biosynthesis inhibitor (D1) examples include anilinopyrimidines such as cyprodinil, mepanipyrim, pyrimethanil and the like.
  • Protein synthesis inhibitor (D2) examples include enopyranuronic acid antibiotics such as blasticidin S (blasticidin-S) and the like.
  • Protein synthesis inhibitor (D3) examples include hexopyranosyl antibiotics such as kasugamycin and the like.
  • Protein synthesis inhibitor (D4) examples include glucopyranosyl antibiotics such as streptomycin, and the like.
  • Protein synthesis inhibitors include, for example, tetracycline antibiotics such as oxytetracycline.
  • E signal transduction inhibitor with unknown mechanism
  • E2 MAP ⁇ histidine kinase
  • E3 MAP ⁇ histidine in osmotic signaling Kinase inhibitors
  • Signal transduction inhibitor of unknown mechanism examples include allyloxyquinolines such as quinoxyfen and the like; quinazolinones such as proquinazid and the like.
  • MAP ⁇ Histidine kinase (os-2, HOG1) (E2) in osmotic signaling examples include phenylpyrroles such as fenpiclonil, fludioxonil, and the like.
  • MAP and histidine kinase inhibitors (os-1, Daf1) E3 in osmotic signaling
  • MAP and histidine kinase inhibitors (os-1, Daf1) in osmotic signaling for example, clozolinate (chlozolinate), procymidone (procymone), isoprodione (isoprodione), vinclozolin, vinclozolin, dimethaclone, etc.
  • Dicarboximides and the like can be mentioned.
  • F group structure or function of lipid biosynthesis or transport / cell membrane
  • F2 methyltransferase inhibitors of phospholipid biosynthesis
  • F3 lipid peroxidation inhibitors
  • F4 cell membrane-permeant fatty acids
  • F6 Microbial disturbance of pathogen cell membrane
  • F7 cell membrane disrupter
  • F8 ergosterol binder
  • F9 lipid homeostasis
  • Methyltransferase inhibitors (F2) of phospholipid biosynthesis examples include phosphorothiolates such as pyrazophos, edifenphos, iprobenfos and the like; dithiolanes such as isoprothiolane and the like Etc.
  • Lipid Peroxidation Inhibitor examples include aromatic hydrocarbons such as tecnazen, dichloran, quintozene, biphenyl, tolclofos-methyl, chloroneb, etc. And 1,2,4-thiadiazoles such as etridiazole.
  • Cell membrane permeable fatty acid examples include carbamates such as prothiocarb, iodocarb, propamocarb, propamocarb hydrochloride salt and the like.
  • Microbial perturbation of pathogen cell membranes include, for example, Bacillus genus such as Bacillus amyloliquefaciens (synonym Bacillus subtilis) strains: QSR 713 FZB24 MBI 600 D747 and produced bactericidal lipopeptides.
  • Cell membrane disruptor As disrupters of cell membranes, for example, terpenoid compounds such as eugenol (eugenol), geraniol (geraniol), thymol (thymol), plant extracts containing these compounds, terpene hydrocarbons such as essential oils, and terpene alcohols And terpene phenols.
  • terpenoid compounds such as eugenol (eugenol), geraniol (geraniol), thymol (thymol), plant extracts containing these compounds, terpene hydrocarbons such as essential oils, and terpene alcohols And terpene phenols.
  • Ergosterol binder examples include amphoteric amphiphilic macrolide antifungal antibiotics produced by actinomycetes Streptomyces natalensis or S. chattanoogensis such as natamycin (natamycin).
  • Inhibitors of lipid homeostasis, metastasis, storage F9
  • Examples of the inhibitor of lipid homeostasis, transfer and storage include piperidinylthiazole isoxazolines such as oxathiapiproline and the like.
  • G group sterol biosynthesis of cell membrane
  • G1 sterol biosynthesis of cell membrane
  • G2 sterol biosynthesis of cell membrane
  • G3 3-ketoreductase inhibitors
  • G4 inhibitors of squalene epoxidase
  • Inhibitors of C14 demethylation in sterol biosynthesis examples include azaconazole (azaconazole), bitertanol (bitertanol), bromuconazole (bromuconazole), cyproconazole (cyproconazole), difenoconazole (difenoconazole), diniconazole (diniconazole) ), Epoxiconazole (epoxiconazole), etaconazole (etaconazole), fenbuconazole (fenbuconazole), fluquinconazole (fluquinconazole), flusiazole (flusilazole), flutriahol (flutriafol), hexaconazole (hexaconazole), imibenconazole (Imibenzonazole), ipconazole (ipconazole), metconazole (metconazole)
  • ⁇ 14 Reductase and ⁇ 8 ⁇ ⁇ 7 Isomerase (G2) in Sterol Biosynthesis examples include morpholinins such as aldimorph, fenpropimorph, tridemorph and dodemorph; fenpropidin, And piperidines such as piperalin; spiroketal amines such as spiroxamine and the like.
  • 3-ketoreductase inhibitors in C4 demethylation
  • 3-ketoreductase inhibitors in demethylation at the C4 position include hydroxyanilides such as fenhexamid; aminopyrazolinones such as fenpyrazamine.
  • Inhibitors of squalene epoxidase in sterol biosynthesis examples include thiocarbamates such as naftifine and terbinafine; and thiocarbamates such as pyributicarb.
  • H group cell wall biosynthesis
  • H4 chitin biosynthesis inhibitors
  • H5 cellulose synthesis inhibitors
  • Chitin biosynthesis inhibitor examples include peptidyl pyrimidine nucleosides such as polyoxin B (polyoxine B) and the like.
  • Cellulose synthesis inhibitors include, for example, dimethomorph, flumorph, cinnamic acid amides such as pyrimorph, etc .; mandelic acid amides such as mandipropamide, etc .; iprovalicarb; (Benthiavalicarb), valine amide carbamates such as valifenacarb (valifenalate) and the like.
  • group I melanin biosynthesis in cell walls
  • reductase inhibitor (I1) in melanin biosynthesis
  • dehydratase inhibition in melanin biosynthesis I2
  • polyketide synthesis inhibition in melanin biosynthesis I3
  • Reductase inhibitors in melanin biosynthesis examples include isobenzofuranones such as phthalide; pyrroloquinolinones such as pyroquilon; and triazolobenzothiazoles such as tricyclazole.
  • Dehydration enzyme inhibition in melanin biosynthesis examples include carboxamides such as diclocymet; cyclopropanecarboxamides such as carpropamide; propionamides such as fenoxanil and the like.
  • Polyketide synthesis inhibitor in melanin biosynthesis examples include trifluoroethyl carbamates such as tolprocarb, and the like.
  • ⁇ M group> Compounds that target multiple action points (M)
  • compounds (M) targeted to multiple action points include copper compounds (M1), sulfur compounds (M2), dithiocarbamate compounds and their related compounds (M3), phthalimide compounds (M4), chloronitriles Compounds (M5), sulfamide compounds (M6), bisguanidine compounds (M7), triazine compounds (M8), anthraquinone compounds (M9), quinoxaline compounds (M10), maleimide compounds (M11), etc. It can be mentioned.
  • Preferred compounds (M) targeted for multiple action points are M1, M3 and M5.
  • Copper compound (M1) As the copper compound, for example, inorganic compounds such as DBEDC, basic copper chloride (copper oxychloride), basic copper sulfate (copper sulfate), copper hydroxide (copper hydroxide), copper nonylphenol sulfonate (copper nonylphenol sulfonate), etc. (Does not contain sulfur) and the like.
  • inorganic compounds such as DBEDC, basic copper chloride (copper oxychloride), basic copper sulfate (copper sulfate), copper hydroxide (copper hydroxide), copper nonylphenol sulfonate (copper nonylphenol sulfonate), etc. (Does not contain sulfur) and the like.
  • Sulfur based compounds As a sulfur type compound, inorganic compounds (it does not contain copper), such as sulfur (sulfur) and a lime sulfur compound (lime sulfur), etc. are mentioned, for example.
  • Dithiocarbamate compounds and related compounds examples include ferbam, metiram, thiram, manzeb (mancozeb), propineb (propineb), zineb (zineb), zinc thiazole (zinc thiazole), and the like. And dithiocarbamates and analogs such as maneb ziram.
  • Phthalimide compound (M4) examples include phthalimides such as captan, captafol, and folpet.
  • Chloronitrile compound (M5) examples include chloronitriles (phthalonitriles) such as chlorothalonil and the like.
  • Sulfamide compounds M6
  • Examples of the sulfamide compounds include sulfamides such as dichlofluanid and tolylfluanid.
  • Bisguanidine compound (M7) examples include bisguanidines such as guazatine and iminoctadine.
  • Triazine-based compounds (M8) As a triazine type compound, triazines, such as anilazine (anilazine), etc. are mentioned, for example.
  • Anthraquinone compound (M9) Examples of anthraquinone compounds include quinones (anthraquinones) such as dithianon (dithianon) and the like.
  • quinoxaline compounds examples include quinoxalines such as quinomethionate and quinomethionate.
  • maleimide compound (M11) examples include maleimide compounds (M11) such as fluoroimide.
  • thiocarbamate compound examples include thiocarbamates such as metasulfocarb and the like.
  • P group resistance plant life inducer of host plant
  • resistance inducer which stimulates salicylic acid pathway (P1)
  • resistance plant inducer of host plant P2, 3, 4
  • resistance of host plant Plant extracts P5 to be induced
  • microorganisms and microorganism preparations P6 to induce resistance of host plants, and the like
  • Resistance inducer which stimulates the salicylic acid pathway
  • resistance inducers salicylic acid signaling
  • benzothiadiazole BTH such as acibenzolar-S-methyl
  • Host plant resistance inducer P2
  • Examples of resistance inducers for host plants include benzisothiazoles such as probenazole and the like.
  • Host plant resistance inducer P3
  • Examples of resistance inducers for host plants include thiadiazole carboxamides such as isothianyl, thiazinyl, and the like.
  • Host plant resistance inducer P4
  • Examples of resistance inducers for host plants include polysaccharides such as laminarin, and the like.
  • Plant extract (P5) which induces resistance of host plant
  • plant extracts anthraquinone elicitors, plant extracts
  • plant extracts that induce resistance of host plants
  • extracts of plants of the genus Reynoutria Oitadori
  • Reynoutria sachalinensis Giant knotweed
  • essential oils etc.
  • Microorganisms and microbial preparations that induce resistance of host plants include Bacillus cereus such as Bacillus mycoides or preparations thereof.
  • Inducers of host plant resistance examples include ethylphosphonates such as fosetyl, fosetyl-al, etc .; phosphorous acids, phosphites, etc. .
  • cyanoacetamide oxime such as cymoxanil; phthalamic acid such as teclofthalam; phenylacetamide such as cyflufenamide etc .; fluthianil (fluthianil)
  • Cyanomethylene thiazolidines acetic acid 4-quinoline such as tebufloquin; glucopyranosyl antibiotics such as validamycin; benzotriazines such as triazoloxide; benzenesulfonamides such as flusulfamide; dichromedines Pyridazinones such as (diclomezine); guanidines such as dodine; tetrazolyl oxime such as picarbutrazox and the like.
  • more preferable bactericidal agents are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim-methyl, picoxystrobin, ciazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxospoco Nazole fumaric acid salt, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, fluopicolide, propamocarb hydrochloride, fosetyl aluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt and shimoxanyl.
  • synergistic bactericidal composition a bactericidal composition having a synergistic control effect (synergistic effect).
  • the bactericidally active compound is usually 0.1 to 20000 parts by weight, preferably 1 to 10000 parts by weight, more preferably 5 to 5000 parts by weight based on 100 parts by weight of the nitrophenol compound of the general formula (1). Mix.
  • the nitrophenol compound and the bactericidal active compound may be simply added without adding other components, but usually, a solid carrier, a liquid carrier and a gaseous carrier (propellant) are mixed and necessary.
  • a solid carrier usually, a liquid carrier and a gaseous carrier (propellant) are mixed and necessary.
  • surfactants and other pharmaceutical auxiliaries according to the formulation and formulate into oil, emulsion, wettable, flowable, granules, powder, aerosol, aerosol etc according to the usual formulation method Good to use.
  • the total amount of the nitrophenol compound as an active ingredient and the bactericidal active compound is usually contained in an amount of 0.01 to 95% by weight, preferably 0.1 to 50% by weight.
  • solid carriers used in formulation include clays (kaolin clay, diatomaceous earth, synthetic hydrous silicon oxide, bentonite, hubashi clay, acid clay etc), talcs, ceramics, other inorganic minerals (celite, quartz, Fine powders or particles of sulfur, activated carbon, calcium carbonate, hydrated silica, etc., chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, sodium chloride etc.) and the like can be mentioned.
  • clays kaolin clay, diatomaceous earth, synthetic hydrous silicon oxide, bentonite, hubashi clay, acid clay etc
  • talcs ceramics
  • other inorganic minerals celite, quartz, Fine powders or particles of sulfur, activated carbon, calcium carbonate, hydrated silica, etc.
  • chemical fertilizers ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, sodium chloride etc.
  • liquid carrier examples include water, alcohols (methanol, ethanol etc.), ketones (acetone, methyl ethyl ketone etc.), aromatic hydrocarbons (benzene, toluene, xylene, ethylbenzene, methyl naphthalene etc.), aliphatic hydrocarbons (Hexane, cyclohexane, kerosene, light oil etc.), esters (ethyl acetate, butyl acetate etc.), nitriles (acetonitrile, isobutyronitrile etc.), ethers (diisopropyl ether, dioxane etc.), acid amides (N , N-dimethylformamide, N, N-dimethylacetamide and the like), halogenated hydrocarbons (dichloromethane, trichloroethane, carbon tetrachloride and the like), vegetable oils such as dimethylsulfoxide, soybean oil, cotton,
  • gaseous carrier examples include butane gas, LPG (liquefied petroleum gas), dimethyl ether, carbon dioxide gas and the like.
  • alkyl sulfates, alkyl sulfonates, alkyl aryl sulfonates, alkyl aryl ethers and their polyoxyethylene derivatives, polyethylene glycol ethers, polyhydric alcohol esters, sugar alcohol derivatives, etc. can be mentioned.
  • a sticking agent As a formulation adjuvant, a sticking agent, a dispersing agent, a stabilizer etc. are mentioned, for example.
  • the fixing agent and / or the dispersing agent for example, casein, gelatin, polysaccharide (starch powder, gum arabic, cellulose derivative, alginic acid etc.), lignin derivative, bentonite, saccharide, synthetic water-soluble polymer (polyvinyl alcohol, polyvinyl pyrrolidone) And polyacrylic acids, etc.).
  • the stabilizer for example, PAP (isopropyl acid phosphate), BHT (2,6-di-tert-butyl-4-methylphenol), BHA (2-tert-butyl-4-methoxyphenol and 3-tert- (Butyl 4-methoxyphenol mixture), vegetable oil, mineral oil, fatty acid or ester thereof and the like.
  • the disinfectant of the present invention may be used as it is or diluted with water or the like. It is also used simultaneously with or without mixing with other insecticides, nematocides, acaricides, fungicides, herbicides, plant growth regulators, synergists, soil conditioners, animal feed etc. It can also be done.
  • composition of the present invention When the composition of the present invention is used as an agricultural bactericide, its application amount is usually 0.1 g to 500 g, preferably 1 to 100 g, per 1000 m 2 .
  • present synergistic germicidal composition of the present invention in the form of emulsion, wettable powder, flowable and the like is used after dilution with water, its application concentration is usually 1 to 1000 ppm, preferably 10 to 500 ppm. Powders and the like are applied as they are, without dilution.
  • the application concentration of the nitrophenol compound is usually about 0.5 to 800 ppm, preferably about 12.5 to 400 ppm, more preferably about 100 to 200 ppm, and the application concentration of the bactericidal compound is usually 0.1 to It is about 200 ppm, preferably about 0.1 to 50 ppm, and more preferably about 0.4 to 20 ppm.
  • the nitrophenol compound and the bactericidal active compound are contained to explain the use thereof, but a composition separately containing the nitrophenol compound and the bactericidal active compound is prepared.
  • these two compositions may be used sequentially or simultaneously, preferably simultaneously, in controlling agricultural and horticultural pathogens.
  • the nitrophenol compound and the bactericidal compound may be used in combination in the same proportion as described above.
  • the synergistic fungicidal composition of the present invention can control plant diseases caused by fungi, eubacteria and plant viruses depending on the application form.
  • the eubacteria that the synergistic microbicidal composition of the present invention can control include, for example, pathogens belonging to the following genera.
  • Burkholderia spp. Rice blight (Burkholderia gladioli), Rice seedling bacterial blight (Burkholderia plantarii);
  • Erwinia spp. Japanese radish soft rot Erwinia carotovora spp. Carotovora
  • Pseudomonas for example, Cucumber spot bacterial blight (Pseudomonas syringae pv. Lachrymans), Radish black spot blight (Pseudomonas syringae pv. Maculicola), Chinese cabbage black spot blight (Pseudomonas cannabina pv.
  • Citri Rhinovorax
  • Acidovorax for example, Watermelon fruit stain bacterial disease
  • Acidovorax avenae spp. Citrulli Watermelon fruit stain bacterial disease
  • Rice brown stripe disease Acidovorax avenae spp. Avenae
  • Clavibacter for example, Tomato scab (Clavibacter michiganensis spp. Michiganensis
  • Streptomyces for example, Potato scum disease (Streptomyces scabies) Etc.
  • Fungi that can be controlled by the synergistic fungicidal composition of the present invention include, for example, pathogens belonging to the following genus.
  • Alternaria spp. Black spot disease of cabbage (Alternaria brassicae), Cabbage scab (Alternaria brassicicola), Potato scab (Alternari solani), Chinese cabbage black spot (Alternaria brassicae, Alternaria brassicicola), Pumpkin black spot (Alternaria cucumerina), Eggplant brown spot (Alternaria solani), Cucumber black spot (Alternaria cucumerina), Apple spotted leaf blight (Alternaria alternata), Carrot black leaf blight (Alternaria dauci), Carrot black spot (Alternaria radicina), Strawberry black spot (Alternaria alternata), Black spot (Alternaria porri) onion, Pear black spot (Alternaria kikuchiana), Onion black spot (Alternaria sp.), Spring onion (Alternaria porri); For example, Aureobasidium spp.
  • Botrytis for example, Strawberry gray mold (Botrytis cinerea), Onion germicidal rot (Botrytis squamosa), Onion gray rot (Botrytis allii), Chinese cabbage leaf blight (Botrytis byssoidea), Green onions (Botrytis squamosa); Colletotrichum spp., For example, Wheat anthracnose (Colletotrichum graminicola), Potato anthracnose (Colletotrichum atramentarium), Komatsuna anthrax (Colletotrichum higginsianum), Azuki Anthracnose (Colletotrichum phaseolorum), Tea anthracnose (Colletotrichum theae-sinensis), Bean bean anthracnose (Colletotrichum lindemuthiamum), Soybean anthracnose (Colletotrichum truncatum), Spinach anthracnose (Colletotrichum graminicola), Potato anthracnose (Col
  • Apple ring leaf blight (Cristulariella moricola); Diplocarpon, for example, Apple brown spot (Diplocarpon mali), Rose scab (Diplocarpon rosae); For example, Diaporthe spp. Citrus sunspot (Diaporthe citri); For example, Elsinoe spp. Grapevine rot (Elsinoe ampelina), Citrus scab (Elsinoe fawcettii); Erysiphe, for example, Barley powdery mildew (Erysiphe graminis f. Sp. Tritici), Wheat powdery mildew (Erysiphe graminis f. Sp.
  • Cucumerinum Melon vines (Fusarium oxysporum f. Sp. Melonis); Fulvia, for example, Tomato leaf mold (Fulvia fulva); Fusicladium genus bacteria, for example, Persimmon scab (Fusicladium levieri); Gaeumannomyces genus bacteria, for example, Rice blight (Gaeumannomyces graminis var. Graminis), Barley dwarf (Gaeumannomyces graminis var.
  • Tritici Gibberella genus bacteria, for example, Rice fool seedling disease (Gibberella fujikuroi), Peach scab (Gibberella zeae); Glomerella genus bacteria, for example, Plum anthracnose (Glomerella cingulata), Ume leaf anthracnose (Glomerella mume), Sweet cherry anthrax (Glomerella cingulata), Grape late rot (Glomerella cingulata), Apple anthrax (Glomerella cingulata), Persimmon fruit disease (Glomerella sp.), Pear anthracnose (Glomerella cingulata), Persimmon leaf anthracnose (Glomerella cingulata), Strawberry anthrax (Glomerella cingulata), Chestnut anthrax (Glomerella cingulata); Gloesporium genus bacteria, for example, Oyster
  • Pleospora for example, Onion leaf blight (Pleospora herbarum), Red clover leaf blight (Pleospora herbarum), Apple brown leaf blight (Pleospora herbarum); Phakopsora genus bacteria, for example, Soybean rust (Phakopsora pachyrhizi); Phomopsis spp., For example, Asparagus stem blight (Phomopsis asparagi), Persimmon sunspot (Phomopsis kakivora); Phyllactinia, for example, Pear powdery mildew (Phyllactinia mali), Pear powdery mildew (Phyllactinia pyri); Phyllosticta, for example, Azuki bean brown rot (Phyllosticta phaseolina), Strawberry ring blight (Phyllosticta fragariicola), Japanese plum blight (Pyllosticta mume); Phy
  • Rhizopus for example, Sweet potato scab (Rhizopus nigricans), Peach black mold (Rhizopus nigricans), Cucumber seedling blight (Rhyzoctonia solani); Rhizoctonia spp., For example, Rice sheath blight (Rhizoctonia solani); For example, Rosellinia sp.
  • Ume white scab (Rosellinia necatrix); For example, Oyster soot disease (Scorias communis), Yamamomo soot disease (Scorias cylindrica); Sphaceloma spp., For example, Japanese sweet potato scum (Sphaceloma pruni-domesticae), Pomegranate scum disease (Sphaceloma punicae), Peanut scab (Sphaceloma arachidis); Sphaerotheca genus bacteria, for example, Ume powdery mildew (Sphaerotheca pannosa), Watermelon powdery mildew (Sphaerotheca fuliginea); Stenella spp., For example, Peach scab (Stenella sp.); Sptoria spp, for example, Black onion blight (Septoria alliacea), Strawberry scab (Septoria fragariae), Sweet potato scab (Sept
  • Grape powdery mildew (Uncinula necator); For example, Verticillium spp. Strawberry wilt (Verticillium dahliae); Venturia, for example, Pear scab (Venturia pirina), Pear scab (Venturia nashicola), Apple scab (Venturia inaequalis); For example, Zygophiala spp. Apple soot blight (Zygophiala jamaicensis), Oyster scum disease (Zygophiala jamaicensis) Etc.
  • a plant virus which can be controlled by the synergistic bactericidal composition of the present invention It is not particularly limited, and examples thereof include Tobamo virus genus, Potex virus genus, Calla virus genus, Cucumovirus type, Calmovirus genus and the like.
  • Tobamovirus genus virus for example, Tobacco mosaic virus (Tobacco mosaic virus, TMV), Tomato mosaic virus (Tomato mosaic virus, ToMV), Cucumber green mottle mosaic virus (Kyuri green mottle mosaic virus, KGMMV), Pepper milled mottle virus (Pepper mild mottle virus, PMMoV), Watermelon green mottle mosaic virus (Cucumber green mottle mosaic virus, CGMMV) etc.
  • TMV Tobacco mosaic virus
  • Tomato mosaic virus Tomato mosaic virus
  • ToMV Cucumber green mottle mosaic virus
  • KGMMV Cucumber green mottle mosaic virus
  • PMMoV Pepper milled mottle virus
  • Watermelon green mottle mosaic virus Cucumber green mottle mosaic virus, CGMMV
  • potex virus genus virus for example, Planago mosaic virus (Plantago asiatica mosaic virus, PlAMV), Potato X virus (Potato virus X, PVX) etc. are mentioned.
  • Potato mosaic virus As a virus of the genus Carla virus, Potato mosaic virus (Potato virus M, PVM) etc. are mentioned.
  • Cucumoviruses include: Cucumber mosaic virus (Cucumber mosaic virus, CMV) etc. are mentioned.
  • carmovirus genus virus for example, Melon necrotic spot virus (Melon necrotic spot virus, MNSV) etc. are mentioned.
  • useful plants for which the synergistic fungicidal composition of the present invention can be used include grains such as rice, barley, wheat, rye, oats and corn; soybeans, red beans, broad beans, peas and beans Beans such as beans and peanuts; Fruits and fruits such as apples, citrus fruits, pears, persimmons, peaches, plums, cherry blossoms, walnuts, chestnuts, almonds, bananas, strawberries, etc .; Leaves, fruits and vegetables such as cabbage, tomato, spinach, broccoli, lettuce, onion, green onion, green pepper, eggplant, pepper and the like; Carrot, potato, sweet potato, taro, radish, lotus root, turnip, burdock, garlic etc root vegetables; Processing crops such as cane, hemp, beets, hops, sugar cane, sugar beet, olives, gum, coffee, tobacco, tea, etc .; Uri species such as pumpkin, cucumber, mackerel, watermelon, melon;
  • the synergistic bactericidal composition of the present invention can protect the above plants by treating such agricultural / horticultural pathogens in the habitat or a plant parasitic to the agricultural / horticultural pathogens or in the vicinity thereof.
  • the habitat of the pest or the plant or its vicinity where the pest infests refers to the vegetation, especially stems, leaves, seeds, bulbs or seeds (hereinafter referred to as seeds, bulbs or seeds) simply as seeds, in which the pest to be controlled is infested It can be applied to fruits, etc.
  • Application methods include, for example, spraying on leaves or stems, or spraying, seed treatment (eg, seed soaking of soaked seeds or granules, etc.), soil application (eg, intercostal spraying or interval spraying of granules, etc.) Etc.).
  • nitrophenol compound can enhance its bactericidal activity by being added to a known germicide. That is, nitrophenol compounds can be used to enhance bactericidal activity.
  • Reference preparation example 1 10 parts of each of the composition of the present invention is dissolved in 45 parts of Solvesso 150 and 35 parts of N-methylpyrrolidone, 10 parts of an emulsifier (trade name: Sorpol 3005X, manufactured by Toho Chemical Co., Ltd.) is added thereto, and mixed by stirring. Each 10% emulsion was obtained.
  • Sorpol 3005X trade name: Sorpol 3005X, manufactured by Toho Chemical Co., Ltd.
  • Reference preparation example 2 (wettable powder) Twenty parts of each of the composition of the present invention is added to 2 parts of sodium lauryl sulfate, 4 parts of sodium lignin sulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of clay and mixed by stirring with a juice mixer. % Wettable powder was obtained.
  • Reference Preparation Example 3 Two parts of sodium dodecylbenzene sulfonate, 10 parts of bentonite and 83 parts of clay were added to 5 parts of each of the composition of the present invention and thoroughly mixed. The applied amount of water was added, and the mixture was further stirred, granulated with a granulator and blow-dried to obtain 5% granules.
  • Reference preparation example 4 1 part of each of the composition of the present invention is dissolved in an appropriate amount of acetone, 5 parts of synthetic hydrous silicon oxide fine powder, 0.3 parts of isopropyl acid phosphate (PAP) and 93.7 parts of clay are added thereto, and a juice mixer The mixture was stirred and mixed, and acetone was removed by evaporation to obtain 1% powder.
  • PAP isopropyl acid phosphate
  • Reference preparation example 5 (flowable agent) Twenty parts of each of the composition of the present invention, 3 parts of polyoxyethylene tristyryl phenyl ether phosphate ester triethanolamine, and 20 parts of water containing 0.2 parts of Rhodorsil 426R are mixed and wet-milled using a dyno mill, It was mixed with 60 parts of water containing 8 parts of propylene glycol and 0.32 parts of xanthan gum to obtain a 20% suspension in water.
  • Formulation B 0.9 part of 4-nitrophenol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) was dissolved in 999.1 parts of water to prepare a water solvent. This water solvent is hereinafter referred to as "formulation B".
  • Formulation C A water solvent was prepared by dissolving 0.6 part of 2-nitrophenol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) in 999.4 parts of water. This water solvent is hereinafter referred to as "Formulation C".
  • Preparation D 0.3 part of 5-nitro guaiacol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) was dissolved in 999.7 parts of water to prepare a water solvent. This water solvent is hereinafter referred to as "Formulation D”.
  • Preparation E Naria (registered trademark) WDG (a water dispersible powder containing 6.8% by weight of pyraclostrobin and 13.6% by weight of boscalid) manufactured by BASF Agro Co., Ltd. is prepared as a water dispersible powder containing pyraclostrobin and boscalid. did. This preparation is referred to as "formulation E”.
  • Formulation F As a flowable agent containing fluazinam, Freonside (registered trademark) SC (a flowable agent containing 39.5% by weight of fluazinam) manufactured by BASF Agro Co., Ltd. was prepared. This preparation is referred to as "formulation F”.
  • Formulation G As a flowable agent containing picoxystrobin, Major (registered trademark) flowable (a flowable agent containing 22.5% by weight of picoxystrobin) manufactured by Japan Pesticides Co., Ltd. was prepared. This preparation is referred to as "formulation G".
  • Formulation H As a flowable agent containing cyazofamide, Lanman (R) flowable (a flowable agent containing 9.4% by weight of cyanophamide) manufactured by Ishihara Biosciences Co., Ltd. was prepared. This preparation is referred to as "formulation H".
  • Formulation I Horison (registered trademark) DF agent (DF agent containing 22.5% by weight of famoxadone and 30% by weight of shimoxanil) manufactured by Nissan Chemical Industries, Ltd. was prepared as a DF agent containing famoxadone and shimoxanil. This preparation is referred to as "formulation I”.
  • Formulation J As a flowable agent containing trifloxystrobin, Flint.RTM. Flowable 25 (a flowable agent containing 25% by weight of trifloxystrobin) manufactured by Bayer CropScience was prepared. This preparation is referred to as "formulation J".
  • Formulation K As a wettable powder containing chlorothalonil, Daconil (registered trademark) 1000 (a wettable powder containing 40% by weight of chlorothalonil) manufactured by Sumitomo Chemical Co., Ltd. was prepared. This preparation is referred to as "formulation K".
  • Formulation L Propose (registered trademark) water dispersible granule manufactured by Kumiai Chemical Industries Co., Ltd. as a water dispersible granule containing bench avaliculum and chlorothalonil (a water dispersible granule containing 5% by weight of bench alkaline carb and 50% by weight of chlorothalonil) Prepared. This preparation is referred to as "formulation L”.
  • Formulation M Strobie (registered trademark) DF (DF agent containing 50% by weight of kresoxim methyl) manufactured by Nissan Chemical Industries, Ltd. was prepared as a DF agent containing kresoxim methyl. This preparation is referred to as "formulation M”.
  • Formulation N 560 parts by weight of potassium dihydrogen phosphite was dissolved in 440 parts of pure water to make a total of 1000 parts by weight. This preparation is referred to as "formulation N".
  • Etofin registered trademark
  • Formulation O a flowable containing Etabaxam
  • Formulation P As a flowable agent containing amethocutrazine and dimethomorph, ZANPRO (registered trademark) DM flowable (a flowable agent containing 27% by weight of ametocutrazine and 20.3% by weight of dimethomorph) manufactured by BASF Agro Co., Ltd. was prepared. This preparation is referred to as "formulation P".
  • Formulation Q Festival (trademark) C wettable powder made by Hokuko Chemical Industry Co., Ltd. as a wettable powder containing dimethomorph and basic copper chloride (wettable powder containing 15% by weight dimethomorph, 58.8% by weight basic copper chloride) Prepared. This preparation is referred to as "formulation Q".
  • Formulation R As a flowable agent containing azoxystrobin, Amister (registered trademark) 20 flowable (a flowable agent containing 20% by weight of azoxystrobin) manufactured by Syngenta Japan Co., Ltd. was prepared. This preparation is referred to as "formulation R".
  • Preparation S As a wettable powder containing manzeb, Dimandaisen (registered trademark) wettable powder (a wettable powder containing 80% by weight of manzeb) manufactured by Dow Chemical Japan Ltd. was prepared. This preparation is referred to as "formulation S".
  • Formulation T Arietti (R) wettable powder (a wettable powder containing 80% by weight) manufactured by Bayer CropScience Co., Ltd. was prepared as a wettable powder containing fosetyl aluminum. This preparation is referred to as "formulation T”.
  • Formulation U As a flowable agent containing fluopicolide and propamocarb hydrochloride, Reliable (registered trademark) flowable (a flowable agent containing 5.5% by weight of fluopicolide and 55.5% of propamocarb hydrochloride) manufactured by Bayer CropScience Co., Ltd. was prepared. This preparation is referred to as "formulation U".
  • Formulation V Yonepon (a solution containing 30% by weight of nonylphenol sulfonic acid copper salt) manufactured by OAT Agrio Co., Ltd. was prepared as a solution containing nonylphenol sulfonic acid copper salt. This preparation is referred to as "formulation V".
  • Formulation W As a solution containing tetraconazole, Salvatore (registered trademark) ME (a solution containing 11.6 parts by weight of tetraconazole) manufactured by Arista Life Science Co., Ltd. was prepared. This preparation is referred to as "formulation W”.
  • Formulation X 50 parts by weight of flutoriahole (manufactured by Sigma) was dissolved in 950 parts by weight of dimethyl sulfoxide (manufactured by Tokyo Kasei Co., Ltd.). This preparation is referred to as "formulation X”.
  • Formulation Y 10 parts by weight of acibenzolar-S-methyl (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 990 parts by weight of dimethyl sulfoxide (manufactured by Tokyo Kasei Kogyo Co., Ltd.). This preparation is referred to as "formulation Y”.
  • Example 1 The above preparation E (pyraclostrobin 68000 ppm, boscalid 136000 ppm) and preparation A (nitrophenol compound 18000 ppm) were mixed to prepare preparation E + A of the composition of the present invention.
  • Formulation E was formulated as formulation F, formulation G, formulation H, formulation I, formulation J, formulation K, formulation L, formulation M, formulation N, formulation O, formulation P, formulation Q, formulation R, described in Tables 1-6.
  • Formulation G + A, Formulation H + A, Formulation I + A, Formulation J + A, Formulation K + A, Formulation L + A, Formulation M + A, Formulation N + A, Formulation O + A, Formulation P + A, Formulation Q + A, Formulation R + A, Formulation S + A, Formulation T + A, Formulation U + A, Formulation V + A, Formulation W + A , Formulation X + A, and formulation Y + A were prepared respectively.
  • Test Example 1 Efficacy Test Against Tomato Phytophthoma
  • the top 3 to 5 leaves of tomato (variety: large-sized Fukuju) grown to about 15 leaf stages were cut 5 cm from the tip and used for the test.
  • the drug was treated by immersing the cut leaves in a drug solution. After the treatment, it was allowed to stand on a plain agar medium with the back of the leaf up and air-dried.
  • a spore suspension of Phytophthora infestans was prepared with a pH 7.0 phosphate buffer to a density of 1 ⁇ 10 5 .
  • One hour after preparation, the spore suspension was sprinkled onto the leaves.
  • Three test zones were established per test zone.
  • the control was grown for 7 days under the conditions of noon: 15 ° C., night 12 ° C., illumination 12 hours. After that, the effect of each drug was evaluated by the affected area.
  • the result is Table 1.
  • the expected effectiveness (E) of the microbicidal composition of the present invention was calculated from the Colby's equation (Weeds, 15, 20-22 (1967)) to obtain the calculated effectiveness (%) .
  • E x + y-(x ⁇ y / 100)
  • E is the percentage of the expected efficacy when using the nitrophenol compound and the bactericidal compound at the respective concentrations p and q.
  • x represents the degree of effectiveness when a nitrophenol compound is used at a concentration p
  • y represents the degree of effectiveness when a bactericidal compound is used at a concentration q.
  • Test Example 2 Efficacy Test against Cucumber Powdery Mildew
  • a 7 cm pot was filled with a culture soil (trade name: Aina No. 1, manufactured by Katakura Coop Aggri Co., Ltd.), and a cucumber was sowed. When the third leaf was developed, a strain with moderate growth was selected and used for the test. After dilution of the drug, 4 ml per share was evenly sprayed by sprayer and allowed to air dry thoroughly.
  • a spore suspension of cucumber powdery mildew (Podosphaera xanthii or Sphaerotheca fuliginea) was prepared with a phosphate buffer of pH 7.0 to a density of 1 ⁇ 10 5 .
  • the spore suspension was sprayed on the surface of the strain evenly with a sprayer. Three test zones were established per test zone. Day: After managing for 7 days in a house at 25 ° C. and at 20 ° C. at night, the effects of each drug were evaluated by the area of disease onset. The results are shown in Table 3.
  • the synergistic bactericide composition (Example 19) of the present invention was found to have a synergetic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value.
  • the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
  • Test Example 3 Efficacy test against cucumber powdery mildew A culture medium (trade name: Aina No. 1, manufactured by Katakura Coop Aggri Co., Ltd.) was packed in a 7 cm pot and the cucumber was sowed. When the third leaf was developed, a strain with moderate growth was selected and used for the test.
  • the agents shown in Table 4 below were dissolved in a 10% by weight aqueous solution of Tween (registered trademark) 20 (the aqueous solution used pure water), and then 4 ml per strain was evenly sprayed by a sprayer and air-dried sufficiently.
  • a spore suspension of cucumber powdery mildew (Podosphaera xanthii) was prepared with a pH 7.0 phosphate buffer to a density of 1 ⁇ 10 5 .
  • the spore suspension was sprayed on the surface of the strain evenly with a sprayer. Three test zones were established per test zone. Day: After managing for 7 days in a house at 25 ° C. and at 20 ° C. at night, the effects of each drug were evaluated by the area of disease onset. The results are shown in Table 3.
  • the synergistic bactericide composition (Example 20) of the present invention was found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value.
  • the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
  • Test Example 4 Efficacy test against cruciferous black spot bacterial disease Prepared at a predetermined concentration shown in the following Table 5 in about 3.5 leaf stage Chinese cabbage grown on a cell tray of 136 holes packed with Aina No. 1 soil The drug was sprayed using a spray gun (Olympos PB-408, 1.0 kgf / cm 2 ) at a spray rate of 6 ml / 8 strain. After spraying, it was allowed to stand in a room (16 L / 8 D) set at about 25 ° C. Two days after the spraying, the cells were spray-inoculated with a fungal solution of Brassicaceae black spot bacteria (Pseudomonas cannabina pv. Alisalensis).
  • the bacterial solution was prepared by diluting it to 1 ⁇ 10 8 cfu / ml with distilled water.
  • Chinese cabbage after inoculation was allowed to stand in a constant temperature and humidity room at 25 ° C. for 24 hours. It was then placed in an assay chamber at 25 ° C. About 7 days after inoculation, the incidence of the entire strain was investigated according to the following criteria to calculate the control value.
  • Test Example 5 Efficacy Test against Cucumber Powdery Mildew Cucumber (variety: Suzunari) grown to 1.2 leaf stage in a 7.5 cm pot packed with Aina No. 1 soil prepared to a predetermined concentration shown in Table 6 below The drug was sprayed at a spray water volume of 4.52 ml / strain using a rotary spray tower. Two days after spraying, it was left in a room (16 L / 8 D) at 25 ° C. Two days after spraying, 2 ml of the conidia suspension of cucumber powdery mildew (Podosphaera xanthi) was sprayed and inoculated.
  • the conidia suspension was prepared by immersing three cucumber leaves affected by powdery mildew on the whole of the first leaf in 100 ml of 0.01% Tween® 20 aqueous solution and shaking for 30 minutes. After inoculation, the cells were cultured in a house maintained at an average of 25 ° C. The control value was calculated by comparing the degree of onset of the entire strain with the untreated area 11 days after inoculation. The results are shown in Table 6.
  • the synergistic bactericidal composition (Examples 30 to 35) of the present invention was found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value.
  • the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.

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Abstract

The purpose of the invention is to provide a bactericide composition having even better preventing/controlling effects against agricultural/horticultural bacteria. The invention relates to a synergistic bactericide composition comprising (A) a nitrophenol compound and (B) a bactericidally active compound. The invention relates to a method for preventing/controlling bacteria, characterized by treating a habitat (except for human beings) of agricultural/horticultural bacteria with said synergistic bactericide composition. The invention relates to a plant protection method characterized by treating a plant infested with agricultural/horticultural bacteria, or the vicinity thereof, with said synergistic bactericide composition. The invention relates to a method for using a nitrophenol compound for enhancing bactericidal activity. The invention relates to a bactericidal activity enhancer comprising a nitrophenol compound.

Description

ニトロフェノール化合物及び殺菌活性化合物を含有する相乗的殺菌剤組成物Synergistic microbicidal composition containing a nitrophenol compound and a bactericidal active compound
　本発明は、ニトロフェノール化合物及び殺菌活性化合物を含有する相乗的殺菌剤組成物に関する。 The present invention relates to a synergistic germicidal composition comprising a nitrophenol compound and a germicidally active compound.
　従来から作物を加害する病害虫の防除を目的に農薬の開発が行われ、多様な薬剤が実用化されている。しかしながら、近年、既存の農薬に対して感受性の低下した個体群が出現しており、既存の農薬では病害虫に対する防除効果が著しく低下している。 BACKGROUND ART Conventionally, agrochemicals have been developed for the purpose of controlling pests that damage crops, and various drugs have been put to practical use. However, in recent years, populations with reduced sensitivity to existing pesticides have appeared, and the existing pesticides have significantly reduced the control effect against pests and diseases.
　そこで、かかる病害虫に対する防除活性を向上させるために様々な開発が行われている。例えば、２種以上の既存の殺菌活性化合物を組み合わせて、相乗効果で殺菌活性を向上させた殺菌剤組成物が開発されてきている（特許文献１）。 Therefore, various developments have been made to improve the control activity against such pests. For example, a bactericidal composition has been developed in which the bactericidal activity is improved by a synergistic effect by combining two or more existing bactericidally active compounds (Patent Document 1).
　一方、ニトロフェノール化合物は、植物の成長促進効果（特許文献２）、ＢＴ毒素（殺虫性タンパク質）の生産促進効果（特許文献３）を有することが開示されているが、ニトロフェノールが殺菌剤の活性増強剤であることは一切記載も示唆もされていない。 On the other hand, nitrophenol compounds are disclosed to have a plant growth promoting effect (Patent Document 2) and a BT toxin (insecticidal protein) production promoting effect (Patent Document 3), but nitrophenol is a bactericidal agent. There is no description or suggestion that it is an activity enhancer.
特開２０１６－１９９５２７号公報JP, 2016-199527, A 中国特許出願公開第１０４６２８４８１号明細書Chinese Patent Application Publication No. 104628481 国際公開第２００４／０１３２８６号WO 2004/013286
　本発明は、農園芸病原菌に対してより一層優れた防除効果を有する相乗的殺菌剤組成物を提供することを課題とする。 An object of the present invention is to provide a synergistic bactericidal composition having an even better control effect against agricultural and horticultural pathogens.
　本発明者は、上記課題を解決するために鋭意研究を重ねた結果、ニトロフェノール化合物が殺菌剤の防除活性を増強させることを見出した。本発明は、このような知見に基づき完成されたものである。 MEANS TO SOLVE THE PROBLEM As a result of repeating earnest research in order to solve the said subject, this inventor discovered that the nitrophenol compound enhances the control activity of a microbicide. The present invention has been completed based on such findings.
　すなわち、本発明は、下記のニトロフェノール化合物及び殺菌活性化合物を含有する相乗的殺菌剤組成物等に関する。 That is, the present invention relates to a synergistic germicidal composition and the like comprising the following nitrophenol compound and a germicidally active compound.
項１．
（Ａ）ニトロフェノール化合物及び（Ｂ）殺菌活性化合物を含有する相乗的殺菌剤組成物。
項２．
（Ｂ）殺菌活性化合物が、
（ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）、
（ｂ２）β－チューブリン重合阻害剤（Ｂ１、２、３）、
（ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）、
（ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、
（ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、
（ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、
（ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）、
（ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）、
（ｂ９）リン脂質生合成のメチルトランスフェラーゼ阻害剤（Ｆ２）、
（ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）、
（ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）、
（ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）、
（ｂ１３）セルロース合成酵素阻害剤（Ｈ５）、
（ｂ１４）メラニン生合成における還元酵素阻害剤（Ｉ１）、
（ｂ１５）メラニン生合成における脱水酵素阻害剤（Ｉ２）、
（ｂ１６）メラニン生合成におけるポリケチド合成阻害剤（Ｉ３）、
（ｂ１７）多作用点を標的とする化合物（Ｍ１～１１）、
（ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、２、３、４、７）、及び
（ｂ１９）作用機序が不明の化合物（Ｕ）
からなる群より選ばれる少なくとも１種の化合物である、項１に記載の相乗的殺菌剤組成物。
項３．
（Ｂ）殺菌活性化合物が、
（ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）、
（ｂ２）β－チューブリン重合阻害剤（Ｂ３）、
（ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）、
（ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、
（ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、
（ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、
（ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）、
（ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）、
（ｂ９）リン脂質生合成のメチルトランスフェラーゼ阻害剤（Ｆ２）、
（ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）、
（ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）、
（ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）、
（ｂ１３）セルロース合成酵素阻害剤（Ｈ５）、
（ｂ１４）メラニン生合成における還元酵素阻害剤（Ｉ１）、
（ｂ１５）メラニン生合成における脱水酵素阻害剤（Ｉ２）、
（ｂ１６）メラニン生合成におけるポリケチド合成阻害剤（Ｉ３）、
（ｂ１７）多作用点を標的とする化合物（Ｍ１～１１）、
（ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、７）、
（ｂ１９）シモキサニル、テクロフタラム、シフルフェナミド、フルチアニル、フェリムゾン、テブフロキン、バリダマイシン、トリアゾキシド、フルスルファミド、ジクロメジン、ドジン、メトラフェノン、ピリオフェノン、及び、ピカルブトラゾックス（Ｕ）
からなる群より選ばれる少なくとも１種の化合物である、項１に記載の相乗的殺菌剤組成物。
項４．
（Ｂ）殺菌活性化合物が、
（ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）、
（ｂ２）β－チューブリン重合阻害剤（Ｂ３）、
（ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）、
（ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、
（ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、
（ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、
（ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）、
（ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）、
（ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）、
（ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）、
（ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）、
（ｂ１３）セルロース合成酵素阻害剤（Ｈ５）、
（ｂ１７）多作用点を標的とする化合物（Ｍ１、３、５）、
（ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、７）、
（ｂ１９）シモキサニル、テクロフタラム、シフルフェナミド、フルチアニル、フェリムゾン、テブフロキン、バリダマイシン、トリアゾキシド、フルスルファミド、ジクロメジン、ドジン、メトラフェノン、ピリオフェノン、及び、ピカルブトラゾックス（Ｕ）からなる群より選ばれる少なくとも１種の化合物である、項１～３の何れか一項に記載の相乗的殺菌剤組成物。
項５．
前記（ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）が、アシルアラニン化合物；
（ｂ２）β－チューブリン重合阻害剤（Ｂ３）が、エチルアミノチアゾールカルボキサミド化合物；
（ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）が、ピリジニルメチルベンゾアミド化合物；
（ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）が、ピリジンカルボキサミド化合物；
（ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）が、メトキシカーバメート化合物、メトキシアクリレート化合物、及びオキシイミノ酢酸化合物、オキサゾリジンジオン化合物；
（ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）が、シアノイミダゾール化合物；
（ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）が、２，６－ジニトロアニリン化合物；
（ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）が、トリアゾロピリミジルアミン化合物；
（ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）が、カーバメート化合物；
（ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）が、ピペリジニルチアゾールイソオキサゾリン化合物；
（ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）が、トリアゾール化合物、及びイミダゾール化合物；
（ｂ１３）セルロース合成酵素阻害剤（Ｈ５）が、桂皮酸アミド化合物、及びマンデル酸アミド化合物；
（ｂ１７）多作用点を標的とする化合物（Ｍ１、３、５）が、銅化合物、ジチオカーバメート化合物、及びクロロニトリル化合物；
（ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、７）が、ベンゾチアジアゾール化合物、エチルホスホナート化合物、及びクロロニトリル化合物；並びに
（ｂ１９）作用機序が不明の化合物（Ｕ）がシアノアセトアミドオキシム化合物である、項４に記載の相乗的殺菌剤組成物。
項６．
（Ｂ）殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも1種の化合物である、項１～５の何れか一項に記載の相乗的殺菌剤組成物。
項７．
前記（Ａ）ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、項１～６の何れか一項に記載の相乗的殺菌剤組成物。
項８．
（Ａ）ニトロフェノール化合物の配合割合が、（Ｂ）殺菌活性成分１００重量部に対して、１～５０００重量部である、項１～７の何れか一項に記載の相乗的殺菌剤組成物。
項９．
項１～８の何れか一項に記載の相乗的殺菌剤組成物を、農園芸病原菌の生息場所（ヒトを除く）に処理することを特徴とする病原菌防除方法。
項１０．
項１～８の何れか一項に記載の相乗的殺菌剤組成物を、農園芸病原菌の生息場所に処理することを特徴とする病原菌防除方法。
項１１．
項１～８の何れか一項に記載の相乗的殺菌剤組成物を、農園芸病原菌が寄生する植物又はその近傍に処理することを特徴とする植物保護方法。
項１２．
殺菌活性増強のためのニトロフェノール化合物の使用方法。
項１３．
殺菌活性化合物の殺菌活性を増強させるためのニトロフェノール化合物の使用方法（ヒトへの適用を除く）であって、
前記殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも１種の化合物である、使用方法。
項１４．
前記ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、項１２又は１３に記載の使用方法。
項１５．
ニトロフェノール化合物を含有する殺菌活性増強剤。
項１６．
殺菌活性化合物に対して、ニトロフェノール化合物を含有する殺菌活性増強剤であって、
前記殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも１種の化合物である、殺菌活性増強剤。
項１７．
前記ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、項１５又は１６に記載の殺菌活性増強剤。 Item 1.
A synergistic germicidal composition comprising (A) a nitrophenol compound and (B) a germicidally active compound.
Item 2.
(B) a bactericidal compound is
(B1) RNA polymerase inhibitor (A1),
(B2) β-tubulin polymerization inhibitor (B1, 2, 3),
(B3) Delocalizer for spectrin-like protein (B5),
(B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2),
(B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3),
(B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4),
(B7) uncoupling agent (C5) in oxidative phosphorylation
(B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8),
(B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2),
(B10) Cell membrane permeable fatty acid (F4),
(B11) lipid homeostasis, metastasis, storage inhibitor (F9),
(B12) Demethylation inhibitor of C14 position in sterol biosynthesis (G1),
(B13) Cellulose synthetase inhibitor (H5),
(B14) Reductase inhibitor (I1) in melanin biosynthesis
(B15) An inhibitor of dehydration enzyme (I2) in melanin biosynthesis
(B16) Polyketide synthesis inhibitor in melanin biosynthesis (I3),
(B17) Compounds (M1 to 11) targeting multiple action points,
(B18) Resistance inducer of host plant (P1, 2, 3, 4, 7), and (b19) Compound (U) whose mechanism of action is unknown
Item 2. The synergistic germicidal composition according to Item 1, which is at least one compound selected from the group consisting of
Item 3.
(B) a bactericidal compound is
(B1) RNA polymerase inhibitor (A1),
(B2) β-tubulin polymerization inhibitor (B3),
(B3) Delocalizer for spectrin-like protein (B5),
(B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2),
(B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3),
(B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4),
(B7) uncoupling agent (C5) in oxidative phosphorylation
(B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8),
(B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2),
(B10) Cell membrane permeable fatty acid (F4),
(B11) lipid homeostasis, metastasis, storage inhibitor (F9),
(B12) Demethylation inhibitor of C14 position in sterol biosynthesis (G1),
(B13) Cellulose synthetase inhibitor (H5),
(B14) Reductase inhibitor (I1) in melanin biosynthesis
(B15) An inhibitor of dehydration enzyme (I2) in melanin biosynthesis
(B16) Polyketide synthesis inhibitor in melanin biosynthesis (I3),
(B17) Compounds (M1 to 11) targeting multiple action points,
(B18) Resistance inducer of host plant (P1, 7),
(B19) Shimoxanil, teclophthalam, cyflufenamide, flutianil, ferimsone, tebufloquine, validamycin, triazoloxide, flusulfamide, diclomedin, dodine, metraphenone, pyriophenone, and picalbutrazox (U)
Item 2. The synergistic germicidal composition according to Item 1, which is at least one compound selected from the group consisting of
Item 4.
(B) a bactericidal compound is
(B1) RNA polymerase inhibitor (A1),
(B2) β-tubulin polymerization inhibitor (B3),
(B3) Delocalizer for spectrin-like protein (B5),
(B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2),
(B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3),
(B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4),
(B7) uncoupling agent (C5) in oxidative phosphorylation
(B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8),
(B10) Cell membrane permeable fatty acid (F4),
(B11) lipid homeostasis, metastasis, storage inhibitor (F9),
(B12) Demethylation inhibitor of C14 position in sterol biosynthesis (G1),
(B13) Cellulose synthetase inhibitor (H5),
(B17) Compounds (M1, 3, 5) targeting multiple action points,
(B18) Resistance inducer of host plant (P1, 7),
(B19) at least one compound selected from the group consisting of shimoxanyl, teclophthalam, cyflufenamide, flutianil, ferimsone, tebufloquine, validamycin, triazoloxide, flusulfamide, diclomedine, dodine, methapenone, pyriophenone, and picalbutrazox (U) The synergistic germicidal composition according to any one of Items 1 to 3, wherein
Item 5.
Said (b1) RNA polymerase inhibitor (A1) is an acyl alanine compound;
(B2) β-tubulin polymerization inhibitor (B3) is an ethylaminothiazole carboxamide compound;
(B3) The delocalizing agent for spectrin-like protein (B5) is a pyridinyl methyl benzamide compound;
(B4) a respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2) is a pyridine carboxamide compound;
(B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3) is a methoxycarbamate compound, a methoxyacrylate compound, and an oximinoacetic acid compound, an oxazolidinedione compound;
(B6) Respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4) is a cyanoimidazole compound;
(B7) The uncoupling agent (C5) in oxidative phosphorylation is a 2,6-dinitroaniline compound;
(B8) Respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8) is a triazolopyrimidyl amine compound;
(B10) Cell membrane permeable fatty acid (F4) is a carbamate compound;
(B11) A lipid homeostasis, transfer, storage inhibitor (F9) is a piperidinyl thiazole isoxazoline compound;
(B12) A demethylation inhibitor (G1) at the C14 position in sterol biosynthesis, a triazole compound, and an imidazole compound;
(B13) The cellulose synthase inhibitor (H5) is a cinnamic acid amide compound, and a mandelic acid amide compound;
(B17) Compounds (M1, 3, 5) targeted to multiple action points are a copper compound, a dithiocarbamate compound, and a chloronitrile compound;
(B18) A host plant resistance inducer (P1, 7) is a benzothiadiazole compound, an ethylphosphonate compound, and a chloronitrile compound; and (b19) a compound (U) of unknown mechanism of action is a cyanoacetamide oxime compound 5. A synergistic germicidal composition according to item 4, which is
Item 6.
(B) The bactericidally active compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cyazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxys Poconazole fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetyl aluminum, phosphorous acid or salts thereof, oxathiapiproline, nonylphenol sulfonic acid The synergistic germicidal composition according to any one of Items 1 to 5, which is at least one compound selected from the group consisting of copper salts and shimoxanyl.
Item 7.
7. The synergistic germicidal composition according to any one of Items 1 to 6, wherein the (A) nitrophenol compound is a phenol compound having one nitro group.
Item 8.
Item 8. The synergistic germicidal composition according to any one of Items 1 to 7, wherein the blending ratio of (A) the nitrophenol compound is 1 to 5000 parts by weight with respect to 100 parts by weight of (B) the bactericidal active ingredient .
Item 9.
Item 9. A method for controlling a pathogen, which comprises treating the synergistic microbicidal composition according to any one of items 1 to 8 in a habitat (except for humans) of agricultural and horticultural pathogens.
Item 10.
Item 9. A method for controlling pathogens, which comprises treating the synergistic germicidal composition according to any one of items 1 to 8 in the habitat of agricultural and horticultural pathogens.
Item 11.
Item 9. A plant protection method comprising treating the synergistic bactericidal composition according to any one of items 1 to 8 to a plant parasitic to agricultural and horticultural pathogens or its vicinity.
Item 12.
Method of using a nitrophenol compound for enhancing bactericidal activity.
Item 13.
Method of using a nitrophenol compound to enhance the bactericidal activity of a bactericidal active compound (except for human application),
The bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetylaluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt And at least one compound selected from the group consisting of and simoxanyl.
Item 14.
14. The method according to item 12 or 13, wherein the nitrophenol compound is a phenol compound having one nitro group.
Item 15.
A bactericidal activity enhancer containing a nitrophenol compound.
Item 16.
It is a bactericidal activity enhancer containing a nitrophenol compound for a bactericidally active compound,
The bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetylaluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt And a bactericidal activity enhancer, which is at least one compound selected from the group consisting of and simoxanyl.
Item 17.
17. The bactericidal activity enhancer according to item 15 or 16, wherein the nitrophenol compound is a phenol compound having one nitro group.
　本発明の相乗的殺菌剤組成物は、低薬量で農園芸病原菌に対して効力を示す。 The synergistic germicidal composition of the present invention is effective against agricultural and horticultural pathogens at low doses.
　本発明の相乗的殺菌剤組成物は、既存の殺菌活性化合物に対して抵抗性を獲得した農園芸病原菌であっても、同様に優れた防除効果を発現する。 The synergistic bactericidal composition of the present invention exerts similarly excellent control effects even on agricultural and horticultural pathogens that have acquired resistance to existing bactericidal compounds.
　さらに、本発明の相乗的殺菌剤組成物によれば、既存の殺菌剤を各々単独で用いた場合に比較して、その処理薬量を低減できることから、各々の殺菌活性化合物に対する農園芸病原菌の抵抗性の発達をも抑制できる。 Furthermore, according to the synergistic bactericidal composition of the present invention, since the treatment dose can be reduced as compared with the case where each existing bactericidal agent is used alone, the agricultural and horticultural pathogens for each bactericidal compound can be reduced. It can also suppress the development of resistance.
　相乗的殺菌剤組成物
　本発明のニトロフェノール化合物及び殺菌活性化合物を含有する相乗的殺菌剤組成物（以下、「本発明組成物」ということもある。）に関して、以下説明する。 Synergistic Bactericidal Composition A synergistic germicidal composition (hereinafter sometimes referred to as "the composition of the present invention") containing the nitrophenol compound of the present invention and a germicidally active compound is described below.
　（Ａ）ニトロフェノール化合物
　（Ａ）ニトロフェノール化合物としては、１つ以上のニトロ基及び１つ以上の水酸基（ＯＨ基）を有した芳香環化合物であれば特に限定はなく、該化合物には、さらに上記ニトロ基及び水酸基以外の置換基を有していてもよい。 (A) Nitrophenol Compound (A) The nitrophenol compound is not particularly limited as long as it is an aromatic ring compound having one or more nitro groups and one or more hydroxyl groups (OH groups). Furthermore, you may have substituents other than the said nitro group and a hydroxyl group.
　置換基としては、特に限定はなく、例えば、ハロゲン原子、Ｃ１～６アルキル基、Ｃ１～６ハロアルキル基、Ｃ１～６アルコキシ基、Ｃ１～６ハロアルコキシ基、Ｃ２～６アルケニル基、Ｃ２～６ハロアルケニル基、Ｃ２～６アルケニルオキシ基、Ｃ２～６ハロアルケニルオキシ基、Ｃ２～６アルキニル基、Ｃ２～６ハロアルキニル基、Ｃ２～６アルキニルオキシ基、Ｃ２～６ハロアルキニルオキシ基等が挙げられる。 The substituent is not particularly limited, for example, a halogen atom, C 1 ~ 6 alkyl group, C 1 ~ 6 haloalkyl group, C 1 ~ 6 alkoxy group, C 1 ~ 6 haloalkoxy group, C 2 ~ 6 alkenyl group , C 2 ~ 6 haloalkenyl groups, C 2 ~ 6 alkenyloxy groups, C 2 ~ 6 haloalkenyloxy groups, C 2 ~ 6 alkynyl groups, C 2 ~ 6 haloalkynyl groups, C 2 ~ 6 alkynyloxy groups, C etc. 2-6 haloalkynyloxy group.
　本明細書におけるニトロフェノール化合物には、塩を形成したニトロフェノール化合物（ニトロフェノール化合物の塩）も含んでいる。 The nitrophenol compound in the present specification also includes a salt-formed nitrophenol compound (a salt of a nitrophenol compound).
　本明細書における塩としては、例えば、アルカリ金属塩（ナトリウム塩、カリウム塩等）、アルカリ土類金属塩（カルシウム塩、マグネシウム塩等）、アンモニウム塩（アンモニア；モルホリン、ピペリジン、ピロリジン、低級モノ、ジ又はトリアルキルアミン、低級モノ、ジ又はトリヒドロキシアルキルアミン等の有機アミン等）等が挙げられ、好ましくは、水溶性で、農芸化学的に有利な塩であり、より好ましくはアルカリ金属塩である。 Examples of salts in the present specification include alkali metal salts (sodium salt, potassium salt and the like), alkaline earth metal salts (calcium salt, magnesium salt and the like), ammonium salt (ammonia; morpholine, piperidine, pyrrolidine, lower mono, Di- or trialkylamines, organic amines such as lower mono-, di- or trihydroxyalkylamines, etc., and the like, and the like, preferably water-soluble, agrochemically advantageous salts, more preferably alkali metal salts. is there.
　中でも、該ニトロフェノール化合物としては、例えば、下記一般式（１）：
Figure JPOXMLDOC01-appb-C000001
  
（式中、Ｘは、Ｃ－Ｒ’基又は窒素原子を示す。
Ｒ、及びＲ’は、同一又は異なって、水素原子、ハロゲン原子、水酸基、ニトロ基、Ｃ１～６アルキル基、Ｃ１～６ハロアルキル基、Ｃ１～６アルコキシ基、Ｃ１～６ハロアルコキシ基、Ｃ２～６アルケニル基、Ｃ２～６ハロアルケニル基、Ｃ２～６アルケニルオキシ基、Ｃ２～６ハロアルケニルオキシ基、Ｃ２～６アルキニル基、Ｃ２～６ハロアルキニル基、Ｃ２～６アルキニルオキシ基、又はＣ２～６ハロアルキニルオキシ基を示す。）
で表されるニトロフェノール化合物又はその塩等が挙げられる。 Among them, as the nitrophenol compound, for example, the following general formula (1):
Figure JPOXMLDOC01-appb-C000001
(Wherein, X represents a C—R ′ group or a nitrogen atom.
R, and R 'are the same or different, a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, C 1 ~ 6 alkyl group, C 1 ~ 6 haloalkyl group, C 1 ~ 6 alkoxy group, C 1 ~ 6 haloalkoxy groups, C 2 ~ 6 alkenyl groups, C 2 ~ 6 haloalkenyl groups, C 2 ~ 6 alkenyloxy groups, C 2 ~ 6 haloalkenyloxy groups, C 2 ~ 6 alkynyl groups, C 2 ~ 6 haloalkynyl groups, C 2-6 alkynyloxy group, or an C 2-6 haloalkynyl group. )
The nitrophenol compound or its salt etc. which are represented by these are mentioned.
　さらに、該ニトロフェノール化合物としては、下記一般式（２）：
Figure JPOXMLDOC01-appb-C000002
  
（式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４、及びＲ５基は、同一又は異なって、水素原子、ハロゲン原子、水酸基、ニトロ基、Ｃ１～６アルキル基、Ｃ１～６ハロアルキル基、Ｃ１～６アルコキシ基、Ｃ１～６ハロアルコキシ基、Ｃ２～６アルケニル基、Ｃ２～６ハロアルケニル基、Ｃ２～６アルケニルオキシ基、Ｃ２～６ハロアルケニルオキシ基、Ｃ２～６アルキニル基、Ｃ２～６ハロアルキニル基、Ｃ２～６アルキニルオキシ基、又はＣ２～６ハロアルキニルオキシ基を示す。）
で表されるニトロフェノール化合物又はその塩等が挙げられる。 Furthermore, as the nitrophenol compound, the following general formula (2):
Figure JPOXMLDOC01-appb-C000002
(Wherein, R 1 , R 2 , R 3 , R 4 and R 5 groups are the same or different and are a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a C 1-6 alkyl group, a C 1-6 haloalkyl groups, C 1 ~ 6 alkoxy groups, C 1 ~ 6 haloalkoxy groups, C 2 ~ 6 alkenyl groups, C 2 ~ 6 haloalkenyl groups, C 2 ~ 6 alkenyloxy groups, C 2 ~ 6 haloalkenyloxy groups, C 2-6 alkynyl group, C 2-6 haloalkynyl group, a C 2-6 alkynyloxy group, or a C 2-6 haloalkynyl group.)
The nitrophenol compound or its salt etc. which are represented by these are mentioned.
　本明細書における各基について以下説明する。 Each group in the present specification is described below.
　ハロゲン原子としては、特に限定はなく、例えば、フッ素原子、塩素原子、臭素原子、ヨウ素原子等が挙げられる。 There is no limitation in particular as a halogen atom, For example, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom etc. are mentioned.
　Ｃ１～６アルキル基としては、特に限定はなく、例えば、メチル基、エチル基、ｎ－プロピル基、イソプロピル基、ｎ－ブチル基、イソブチル基、ｓ－ブチル基、ｔ－ブチル基、ｎ－ペンチル基、イソペンチル基、ネオペンチル基、ｎ－ヘキシル基、イソヘキシル基等の炭素数１～６の直鎖状又は分岐鎖状アルキル基が挙げられる。なお、本明細書において、「ｎ－」とはノルマルを、「ｓ－」とはセカンダリーを、「ｔ－」とはターシャリーを示す。 The C 1-6 alkyl group is not particularly limited, and examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, an s-butyl group, a t-butyl group, and n- Examples thereof include linear or branched alkyl groups having 1 to 6 carbon atoms such as pentyl group, isopentyl group, neopentyl group, n-hexyl group and isohexyl group. In the present specification, "n-" indicates normal, "s-" indicates secondary, and "t-" indicates tertiary.
　Ｃ１～６ハロアルキル基としては、特に限定はなく、例えば、フルオロメチル基、クロロメチル基、ブロモメチル基、ヨードメチル基、ジフルオロメチル基、トリフルオロメチル基、１－フルオロエチル基、２－フルオロエチル基、２－クロロエチル基、２，２，２－トリフルオロエチル基、ペンタフルオロエチル、１－フルオロプロピル基、２－クロロプロピル基、３－フルオロプロピル基、３－クロロプロピル基、１－フルオロブチル基、１－クロロブチル基、４－フルオロブチル基等の１～９個、好ましくは１～５個のハロゲン原子で置換された炭素数１～６の直鎖状又は分岐鎖状アルキル基が挙げられる。 The C 1-6 haloalkyl group is not particularly limited, and examples thereof include a fluoromethyl group, a chloromethyl group, a bromomethyl group, an iodomethyl group, a difluoromethyl group, a trifluoromethyl group, a 1-fluoroethyl group and a 2-fluoroethyl group. , 2-chloroethyl group, 2,2,2-trifluoroethyl group, pentafluoroethyl, 1-fluoropropyl group, 2-chloropropyl group, 3-fluoropropyl group, 3-chloropropyl group, 1-fluorobutyl group And a linear or branched alkyl group having 1 to 6 carbon atoms substituted with 1 to 9, preferably 1 to 5 halogen atoms such as 1-chlorobutyl and 4-fluorobutyl.
　Ｃ１～６アルコキシ基としては、特に限定はなく、例えば、メトキシ基、エトキシ基、ｎ－プロポキシ基、イソプロポキシ基、ｎ－ブトキシ基、イソブトキシ基、ｓ－ブトキシ基、ｔ－ブトキシ基、ｎ－ペンチルオキシ基、イソペンチルオキシ基、ネオペンチルオキシ基、ｎ－ヘキシルオキシ基、イソヘキシルオキシ基等の炭素数１～６の直鎖状又は分岐鎖状アルコキシ基が挙げられる。 The C 1-6 alkoxy group is not particularly limited, and examples thereof include a methoxy group, an ethoxy group, an n-propoxy group, an isopropoxy group, an n-butoxy group, an isobutoxy group, an s-butoxy group, an s-butoxy group, and an n-butoxy group. And C1-C6 linear or branched alkoxy groups such as pentyloxy group, isopentyloxy group, neopentyloxy group, n-hexyloxy group and isohexyloxy group.
　Ｃ１～６ハロアルコキシ基としては、特に限定はなく、例えば、フルオロメトキシ基、クロロメトキシ基、ブロモメトキシ基、ヨードメトキシ基、ジフルオロメトキシ基、トリフルオロメトキシ基、１－フルオロエトキシ基、２－フルオロエトキシ基、２－クロロエトキシ基、２，２，２－トリフルオロエトキシ基、ペンタフルオロエトキシ、１－フルオロプロポキシ基、２－クロロプロポキシ基、３－フルオロプロポキシ基、３－クロロプロポキシ基、１－フルオロブチル基、１－クロロブトキシ基、４－フルオロブトキシ基等の１～９個、好ましくは１～５個のハロゲン原子で置換された炭素数１～６の直鎖状又は分岐鎖状アルコキシ基が挙げられる The C 1-6 haloalkoxy group is not particularly limited. For example, a fluoromethoxy group, a chloromethoxy group, a bromomethoxy group, an iodomethoxy group, a difluoromethoxy group, a trifluoromethoxy group, a 1-fluoroethoxy group, 2- Fluoroethoxy group, 2-chloroethoxy group, 2,2,2-trifluoroethoxy group, pentafluoroethoxy, 1-fluoropropoxy group, 2-chloropropoxy group, 3-fluoropropoxy group, 3-chloropropoxy group, 1 -C1-C6 linear or branched alkoxy substituted with 1 to 9, preferably 1 to 5 halogen atoms such as -fluorobutyl, 1-chlorobutoxy, 4-fluorobutoxy and the like Group is mentioned
　Ｃ２～６アルケニル基としては、特に限定はなく、例えば、ビニル基、１－プロペニル基、アリル基、イソプロペニル基、１－ブテニル基、２－ブテニル基、３－ブテニル基、１－メチル－２－プロペニル基、１，３－ブタジエニル基等の炭素数２～６の直鎖状又は分岐鎖状アルケニル基が挙げられる。 The C 2 ~ 6 alkenyl group is not particularly limited, for example, vinyl group, 1-propenyl group, allyl group, isopropenyl group, 1-butenyl, 2-butenyl, 3-butenyl group, 1-methyl - And C2-C6 linear or branched alkenyl groups such as 2-propenyl group and 1,3-butadienyl group.
　Ｃ２～６ハロアルケニル基としては、特に限定はなく、例えば、２，２－ジクロロビニル基、２，２－ジブロモビニル基、３－クロロ－２－プロペニル基、３，３－ジフルオロ－２－アリル基、３，３－ジクロロ－２－アリル基、４－クロロ－２－ブテニル基、４，４，４－トリフルオロ－２－ブテニル基、４，４，４－トリクロロ－３－ブテニル基、５－クロロ－３－ペンテニル基、６－フルオロ－２－ヘキセニル基等の任意の位置に少なくとも１つの二重結合を有する炭素数２～６の直鎖状又は分岐鎖状アルケニル基であって、１～１３個、好ましくは１～７個のハロゲン原子で置換されたアルケニル基が挙げられる。 The C 2 ~ 6 haloalkenyl group is not particularly limited, for example, 2,2-dichlorovinyl group, 2,2-dibromo-vinyl group, 3-chloro-2-propenyl group, 3,3-difluoro-2- Allyl group, 3,3-dichloro-2-allyl group, 4-chloro-2-butenyl group, 4,4,4-trifluoro-2-butenyl group, 4,4,4-trichloro-3-butenyl group, A linear or branched alkenyl group having 2 to 6 carbon atoms having at least one double bond at any position such as 5-chloro-3-pentenyl group, 6-fluoro-2-hexenyl group, etc. And alkenyl groups substituted with 1 to 13, preferably 1 to 7 halogen atoms.
　Ｃ２～６アルケニルオキシ基としては、特に限定はなく、例えば、ビニルオキシ基、１－プロペニルオキシ基、アリルオキシ基、イソプロペニルオキシ基、１－ブテニルオキシ基、２－ブテニルオキシ基、３－ブテニルオキシ基、１－メチル－２－プロペニルオキシ基、１，３－ブタジエニルオキシ基等の炭素数２～６の直鎖状又は分岐鎖状アルケニルオキシ基が挙げられる。 C The 2-6 alkenyloxy group is not particularly limited, for example, vinyloxy group, 1-propenyloxy group, allyloxy group, isopropenyloxy group, 1-butenyloxy, 2-butenyloxy, 3-butenyloxy group, 1 And C2-C6 linear or branched alkenyloxy groups such as -methyl-2-propenyloxy group and 1,3-butadienyloxy group.
　Ｃ２～６ハロアルケニルオキシ基としては、特に限定はなく、例えば、２，２－ジクロロビニルオキシ基、２，２－ジブロモビニルオキシ基、３－クロロ－２－プロペニルオキシ基、３，３－ジフルオロ－２－アリルオキシ基、３，３－ジクロロ－２－アリルオキシ基、４－クロロ－２－ブテニルオキシ基、４，４，４－トリフルオロ－２－ブテニルオキシ基、４，４，４－トリクロロ－３－ブテニルオキシ基、５－クロロ－３－ペンテニルオキシ基、６－フルオロ－２－ヘキセニルオキシ基等の任意の位置に少なくとも１つの二重結合を有する炭素数２～６の直鎖状又は分岐鎖状アルケニル基であって、１～１３個、好ましくは１～７個のハロゲン原子で置換されたアルケニル基が挙げられる。 The C 2 ~ 6 haloalkenyloxy group is not particularly limited, for example, 2,2-dichlorovinyl group, 2,2-dibromo-vinyl group, 3-chloro-2-propenyloxy group, 3,3 Difluoro-2-allyloxy group, 3,3-dichloro-2-allyloxy group, 4-chloro-2-butenyloxy group, 4,4,4-trifluoro-2-butenyloxy group, 4,4,4-trichloro-3 —C2-C6 linear or branched chain having at least one double bond at any position such as butenyloxy group, 5-chloro-3-pentenyloxy group, 6-fluoro-2-hexenyloxy group and the like Examples thereof include alkenyl groups substituted with 1 to 13 and preferably 1 to 7 halogen atoms.
　Ｃ２～６アルキニル基としては、例えば、エチニル基、１－プロピニル基、２－プロピニル基、１－メチル－２－プロピニル基、１－ブチニル基、２－ブチニル基、３－ブチニル基等の炭素数２～６の直鎖状又は分岐鎖状アルキニル基が挙げられる。 The C 2 ~ 6 alkynyl group include an ethynyl group, 1-propynyl, 2-propynyl, 1-methyl-2-propynyl group, 1-butynyl group, 2-butynyl group, carbon atoms such as 3-butynyl group And 2 to 6 straight or branched chain alkynyl groups.
　Ｃ２～６ハロアルキニル基としては、特に限定はなく、例えば、３，３，３－トリフルオロプロピニル基、３，３－ジフルオロプロピニル基、３，３，３－トリフルオロブチニル基、４，４，４－トリフルオロ－２－ブチニル基、３，３－ジフルオロ－ブチニル基等の任意の位置に少なくとも１つの三重結合を有する炭素数２～６の直鎖状又は分岐鎖状アルキニル基であって、１～１３個、好ましくは１～７個のハロゲン原子で置換されたアルキニル基が挙げられる。 C The 2-6 haloalkynyl group is not particularly limited, for example, 3,3,3-trifluoro-propynyl group, 3,3-difluoro-propynyl group, 3,3,3-trifluoro-butynyl group, 4, A linear or branched alkynyl group having 2 to 6 carbon atoms which has at least one triple bond at any position such as 4,4-trifluoro-2-butynyl group, 3,3-difluoro-butynyl group, etc. And an alkynyl group substituted with 1 to 13, preferably 1 to 7 halogen atoms.
　Ｃ２～６アルキニルオキシ基としては、特に限定はなく、例えば、エチニルオキシ基、１－プロピニルオキシ基、２－プロピニルオキシ基、１－メチル－２－プロピニルオキシ基、１－ブチニルオキシ基、２－ブチニルオキシ基、３－ブチニルオキシ基等の炭素数２～６の直鎖状又は分岐鎖状アルキニルオキシ基が挙げられる。 The C 2 ~ 6 alkynyloxy group is not particularly limited, for example, ethynyl group, 1-propynyloxy group, 2-propynyl group, 1-methyl-2-propynyl group, 1-butynyloxy group, 2- Examples thereof include linear or branched alkynyloxy groups having 2 to 6 carbon atoms, such as butynyloxy group and 3-butynyloxy group.
　Ｃ２～６ハロアルキニルオキシ基としては、特に限定はなく、例えば、３，３，３－トリフルオロプロピニルオキシ基、３，３－ジフルオロプロピニルオキシ基、３，３，３－トリフルオロブチニルオキシ基、４，４，４－トリフルオロ－２－ブチニルオキシ基、３，３－ジフルオロ－ブチニルオキシ基等の任意の位置に少なくとも１つの三重結合を有する炭素数２～６の直鎖状又は分岐鎖状アルキニルオキシ基であって、１～１３個、好ましくは１～７個のハロゲン原子で置換されたアルキニルオキシ基が挙げられる。 The C 2 ~ 6 haloalkynyloxy group is not particularly limited, for example, 3,3,3-trifluoro-propynyl group, 3,3-difluoro-propynyloxy group, 3,3,3-trifluoro-butynyl-oxy Group, linear or branched having 2 to 6 carbon atoms having at least one triple bond at any position such as 4,4,4-trifluoro-2-butynyloxy, 3,3-difluoro-butynyloxy and the like Examples of the alkynyloxy group include alkynyloxy groups substituted with 1 to 13, preferably 1 to 7 halogen atoms.
　芳香環化合物としては、特に限定はなく、例えば、ベンゼン、ナフタレン、アントラセン等の炭素環化合物；ピリジン、ピリミジン、ピリダジン、ピラジン、ピラゾール等の複素環化合物等が挙げられる。 The aromatic ring compound is not particularly limited, and examples thereof include carbocyclic compounds such as benzene, naphthalene and anthracene; and heterocyclic compounds such as pyridine, pyrimidine, pyridazine, pyrazine and pyrazole.
　上記一般式（１）で表されるニトロフェノール化合物において、ＸがＣ－Ｒ基であるのが好ましい。 In the nitrophenol compound represented by the above general formula (1), X is preferably a C—R group.
　上記一般式（１）で表されるニトロフェノール化合物において、Ｒ’が、水素原子、ハロゲン原子、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子又はメトキシ基がより好ましい。 In nitrophenol compound represented by the above general formula (1), R 'is a hydrogen atom, a halogen atom, is preferably from C 1 ~ 6 alkyl group or a C 1 ~ 6 alkoxy group, a hydrogen atom or a methoxy group More preferable.
　上記一般式（２）で表されるニトロフェノール化合物において、Ｒ１が、水素原子、ハロゲン原子、ニトロ基、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子、ニトロ基、又はメトキシ基がより好ましい。 In the nitrophenol compound represented by the above general formula (2), R 1 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
　上記一般式（２）で表されるニトロフェノール化合物において、Ｒ２が、水素原子、ハロゲン原子、ニトロ基、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子、ニトロ基、又はメトキシ基がより好ましい。 In the nitrophenol compound represented by the above general formula (2), R 2 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
　上記一般式（２）で表されるニトロフェノール化合物において、Ｒ３が、水素原子、ハロゲン原子、ニトロ基、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子、ニトロ基、又はメトキシ基がより好ましい。 In the nitrophenol compound represented by the above general formula (2), R 3 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
　上記一般式（２）で表されるニトロフェノール化合物において、Ｒ４が、水素原子、ハロゲン原子、ニトロ基、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子、ニトロ基、又はメトキシ基がより好ましい。 In the nitrophenol compound represented by the above general formula (2), R 4 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
　上記一般式（２）で表されるニトロフェノール化合物において、Ｒ５が、水素原子、ハロゲン原子、ニトロ基、Ｃ１～６アルキル基又はＣ１～６アルコキシ基であるのが好ましく、水素原子、ニトロ基、又はメトキシ基がより好ましい。 In the nitrophenol compound represented by the above general formula (2), R 5 is preferably a hydrogen atom, a halogen atom, a nitro group, a C 1-6 alkyl group or a C 1-6 alkoxy group, A nitro group or a methoxy group is more preferred.
　また、中でも、４－ニトロフェノール、４－ニトロフェノールナトリウム塩、３－ニトロフェノール、３－ニトロフェノールナトリウム塩、２－ニトロフェノール、２－ニトロフェノールナトリウム塩等のニトロフェノール化合物又はその塩；５－ニトログアヤコール、５－ニトログアヤコールナトリウム塩、４－ニトログアヤコール、４－ニトログアヤコールナトリウム塩等のグアヤコール（別名：グアイアコール）化合物又はその塩が特に好ましい。 And nitrophenol compounds such as 4-nitrophenol, 4-nitrophenol sodium salt, 3-nitrophenol, 3-nitrophenol sodium salt, 2-nitrophenol, 2-nitrophenol sodium salt or salts thereof; Particularly preferred are guaiacol (alias: guaiacol) compounds such as nitroguaiacol, 5-nitroguaiacol sodium salt, 4-nitroguaiacol, 4-nitroguaiacol sodium salt and the like or salts thereof.
　本発明組成物に含有されるニトロフェノール化合物は、公知化合物であり、市販品（アトニック[登録商標]）又は公知の製造方法によって製造した化合物を用いることができる。その製造方法については、例えば、特開平１０－６７７１６に記載されている。上記アトニックは、４－ニトロフェノール（０．３％）、２－ニトロフェノール（０．２％）及び５－ニトログアヤコール（０．１％）を含有する水溶液である。 The nitrophenol compound contained in the composition of the present invention is a known compound, and a commercially available product (Atonic (registered trademark)) or a compound produced by a known production method can be used. The manufacturing method thereof is described, for example, in JP-A-10-67716. The above atomic is an aqueous solution containing 4-nitrophenol (0.3%), 2-nitrophenol (0.2%) and 5-nitroguaiacol (0.1%).
　本発明組成物に含有される殺菌活性化合物としては、農業害虫に対して防除効果を有する化合物として既知の化合物であれば特に限定はない。また、本発明組成物は本発明の効果を奏する限りにおいて、農薬原体としてその他の殺虫剤、殺ダニ剤、殺菌剤を適宜併用することもできる。 The fungicidal compound contained in the composition of the present invention is not particularly limited as long as it is a compound known as a compound having a controlling effect on agricultural pests. In addition, as long as the composition of the present invention exerts the effects of the present invention, other pesticides, acaricides and fungicides can be appropriately used in combination as a pesticide.
　（Ｂ）殺菌活性化合物
　（Ｂ）殺菌活性化合物としては、特に限定はなく、例えば、ＦＲＡＣ（Fungicide Resistance Action Committee；殺菌剤抵抗性対策委員会）による作用分類において、Ａ（核酸合成）、Ｂ（有糸核分裂と細胞分裂）、Ｃ（呼吸）、Ｄ（アミノ酸及び蛋白質生合成）、Ｅ（シグナル伝達）、Ｆ（脂質生合成又は輸送／細胞膜の構造又は機能）、Ｇ（細胞膜のステロール生合成）、Ｈ（細胞壁生合成）、Ｉ（細胞壁のメラニン生合成）、Ｐ（宿主植物の抵抗生誘導）、Ｍ（多作用点接触活性化合物）、Ｕ（作用機構不明）、未分類に属する化合物等が挙げられる。中でも、下記Ａグループ、Ｂグループ、Ｃグループ、Ｆグループ、Ｇグループ、Ｈグループ、Ｍグループ、Ｕグループが好ましく、下記グループ（Ａ１）、グループ（Ｂ１、２、３、Ｂ５）、グループ（Ｃ２、Ｃ３、Ｃ４、Ｃ５、Ｃ８）、グループ（Ｆ４、Ｆ９）、グループ（Ｇ１）、グループ（Ｈ５）、グループ（Ｍ１、３、５）、及び
グループ（Ｕ）がより好ましい。 (B) Bactericidally Active Compound (B) The bactericidal active compound is not particularly limited, and, for example, A (nucleic acid synthesis), B (in the action classification by FRAC (Fungicide Resistance Action Committee) Mitotic division and cell division), C (respiration), D (amino acid and protein biosynthesis), E (signal transduction), F (lipid biosynthesis or transport / cell membrane structure or function), G (cell membrane sterol biosynthesis) ), H (cell wall biosynthesis), I (melanin biosynthesis of cell wall), P (resistance growth induction of host plant), M (multifunctional contact compound), U (action mechanism unknown), compounds not classified Etc. Among them, the following group A, group B, group C, group F, group G, group H, group M and group U are preferable, and the following group (A1), group (B1, 2, 3, B5), group (C2, C3, C4, C5, C8), group (F4, F9), group (G1), group (H5), group (M1, 3, 5), and group (U) are more preferable.
　＜Ａグループ＞
　Ａグループ（核酸合成）としては、例えば、ＲＮＡポリメラーゼ阻害剤（Ａ１）、アデノシンデアミナーゼ（Ａ２）、ＤＮＡ/ＲＮＡ生合成阻害剤（Ａ３）、ＤＮＡトポイソメラーゼ（Ａ４）等が挙げられる。 <A group>
Examples of group A (nucleic acid synthesis) include RNA polymerase inhibitor (A1), adenosine deaminase (A2), DNA / RNA biosynthesis inhibitor (A3), DNA topoisomerase (A4) and the like.
　ＲＮＡポリメラーゼ阻害剤（Ａ１）
　ＲＮＡポリメラーゼ阻害剤としては、例えば、ベナラキシル（benalaxyl）、ベナラキシルＭ（benalaxyl-M）、フララキシル（furalaxyl）、メタラキシル（metalaxyl）、メタラキシルＭ（metalaxyl-M）等のアシルアラニン類；オフレセ（ofurace）等のブチロラクトン類；オキサジキシル（oxadixyl）等のオキサゾリジノン類等が挙げられる。 RNA polymerase inhibitor (A1)
RNA polymerase inhibitors include, for example, acylalanines such as benalaxyl (benalaxyl), benalaxyl M (benalaxyl-M), furalaxyl (furalaxyl), metalaxyl (metalaxyl), metalaxyl M (metalaxyl-M), etc. ofurace etc. Butyrolactones; oxazolidinones such as oxadixyl; and the like.
　アデノシンデアミナーゼ（Ａ２）
　アデノシンデアミナーゼとしては、例えば、ブピリメート（bupirimate），ジメチリロム（dimethirimol）、エチリモール（ethirimol）等のヒドロキシ(２－アミノ－)ピリミジン類等が挙げられる。 Adenosine deaminase (A2)
Examples of adenosine deaminase include hydroxy (2-amino-) pyrimidines such as bupirimate, dimethirimol, ethirimol and the like.
　ＤＮＡ/ＲＮＡ生合成阻害剤（Ａ３）
　ＤＮＡ/ＲＮＡ生合成阻害剤としては、例えば、ヒメキサゾール（hymexazole）等のイソオキサゾール類、オクチリノン（octhilinone）等のイソチアゾロン類等が挙げられる。 DNA / RNA biosynthesis inhibitor (A3)
Examples of DNA / RNA biosynthesis inhibitors include isoxazoles such as hymexazole and isothiazolones such as octhilinone.
　ＤＮＡトポイソメラーゼ（Ａ４）
　ＤＮＡトポイソメラーゼとしては、例えば、オキソリニック酸（oxolinic acid）等のカルボン酸類等が挙げられる。 DNA topoisomerase (A4)
Examples of the DNA topoisomerase include carboxylic acids such as oxolinic acid, and the like.
　＜Ｂグループ＞
　Ｂグループ（有糸核分裂と細胞分裂）としては、例えば、β－チューブリン重合阻害剤（Ｂ１、２、３）、細胞分裂阻害剤（Ｂ４）、スペクトリン様タンパク質の非局在化剤（Ｂ５）、小胞輸送のようなアクチン・ミオシン・フィンブリンの機能の阻害剤（Ｂ６）等が挙げられる。 <B group>
As group B (mitotic division and cell division), for example, β-tubulin polymerization inhibitor (B1, 2, 3), cell division inhibitor (B4), delocalizing agent of spectrin-like protein (B5) ), Inhibitors of actin, myosin and fimbrin functions such as vesicle transport (B6) and the like.
　β－チューブリン重合阻害剤（Ｂ１）
　β－チューブリン重合阻害剤としては、例えば、ベノミル（benomyl）、フベリダゾール（fuberidazole）、カルベンダジム（carbendazim）、チアベンダゾール（thiabendazole）等のベンゾイミダゾール類；チオファネート（thiophanate）、チオファネートメチル（thiophanate-methyl）等のチオファネート類等が挙げられる。 β-tubulin polymerization inhibitor (B1)
Examples of β-tubulin polymerization inhibitors include benzamyls such as benomyl, fuberidazole, carbendazim, thiabendazole, etc .; thiophanate, thiophanate methyl, etc. And thiophanates of
　β－チューブリン重合阻害剤（Ｂ２）
　β－チューブリン重合阻害剤としては、例えば、ジエトフェンカルブ（diethofencarb）等のＮ－フェニルカーバメート類等が挙げられる。 β-tubulin polymerization inhibitor (B2)
Examples of the β-tubulin polymerization inhibitor include N-phenyl carbamates such as diethofencarb.
　β－チューブリン重合阻害剤（Ｂ３）
　β－チューブリン重合阻害剤としては、例えば、ゾキサミド（zoxamide）等のトルアミド類；エタボキサム（ethaboxam）等のエチルアミノチアゾールカルボキサミド等が挙げられる。 β-tubulin polymerization inhibitor (B3)
Examples of the β-tubulin polymerization inhibitor include toluamides such as zoxamide; ethylaminothiazole carboxamides such as ethaboxam; and the like.
　細胞分裂阻害剤（Ｂ４）
　細胞分裂阻害剤としては、例えば、ペンシクロン（pencycuron）等のフェニルウレア類等が挙げられる。 Cell division inhibitor (B4)
Examples of cell division inhibitors include phenylureas such as pencycuron and the like.
　スペクトリン様タンパク質の非局在化剤（Ｂ５）
　スペクトリン様タンパク質の非局在化剤としては、例えば、フルオピコリド（fluopicolide）等のピリジニルメチルベンゾアミド類等が挙げられる。 Delocalization agent of spectrin-like protein (B5)
Examples of the delocalization agent for spectrin-like protein include pyridinylmethyl benzamides such as fluopicolide, and the like.
　小胞輸送のようなアクチン・ミオシン・フィンブリンの機能の阻害剤（Ｂ６）
　小胞輸送のようなアクチン・ミオシン・フィンブリンの機能の阻害剤としては、例えば、フェナマクリル（phenamacril）等のアミノシアノアクリレート類；メトラフェノン（metrafenone）等のベンゾフェノン；ピリオフェノン（pyriofenone）等のベンゾイルピリジン等が挙げられる。 Inhibitors of actin, myosin and fimbrin functions such as vesicle transport (B6)
Examples of inhibitors of actin, myosin and fimbrin functions such as vesicle transport include aminocyanoacrylates such as phenamacril; benzophenones such as metrafenone; benzoylpyridines such as pyriofenone Can be mentioned.
　＜Ｃグループ＞
　Ｃグループ（呼吸）としては、例えば、呼吸鎖複合体I（ＮＡＤＨオキシダーゼ）阻害剤（Ｃ１）、呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、酸化的リン酸化における脱共役剤（Ｃ５）、ＡＴＰ合成における酸化的リン酸化の阻害剤（Ｃ６）、ＡＴＰ生成阻害剤（Ｃ７）、呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）等が挙げられる。 <C group>
As group C (respiratory), for example, respiratory chain complex I (NADH oxidase) inhibitor (C1), respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2), respiratory chain complex III (ubiquinol) Oxidase, Qo site) inhibitor (C3), respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4), uncoupling agent in oxidative phosphorylation (C5), inhibition of oxidative phosphorylation in ATP synthesis The agent (C6), the ATP production inhibitor (C7), the respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8) and the like can be mentioned.
　呼吸鎖複合体I（ＮＡＤＨオキシダーゼ）阻害剤（Ｃ１）
呼吸鎖複合体I（ＮＡＤＨオキシダーゼ）阻害剤としては、例えば、ジフルメトリム（diflumetorim）等のピリミジンアミン類；トルフェンピラド（tolfenpyrad）等のピラゾールカルボキサミド類；フェナザキン(fenazaquin)等のキナゾリン等が挙げられる。 Respiratory chain complex I (NADH oxidase) inhibitor (C1)
Examples of respiratory chain complex I (NADH oxidase) inhibitors include pyrimidine amines such as diflumetrim; pyrazole carboxamides such as tolfenpyrad; quinazolines such as fenazaquin; and the like.
　呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）
　呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤としては、例えば、ベノダニル（benodanil）、フルトラニル（flutolanil）、メプロニル（mepronil）等のフェニルベンズアミド類；イソフェタミド（isofetamid）等のフェニルオキソエチルチオフェンアミド類；フルオピラム（fluopyram）等のピリジニルエチルベンズアミド類；フェンフラム（fenfuram）等のフランカルボキサミド類；カルボキシン（carboxin）、オキシカルボキシン（oxicarboxin）等のオキサチインカルボキサミド類；チフルザミド（thifluzamide）等のチアゾールカルボキサミド類；ベンゾビンジフルピル（benzovindiflupyr）、ビキサフェン（bixafen）、フルインダピル(fluindapyr)、フルキサピロキサド（fluxapyroxad）、フラメトピル（furametpyr）、イソピラザム（isopyrazam）、ペンフルフェン（penflufen）、イソピラザム（isopyrazam）、セダキサン（sedaxane）等のピラゾール-4-カルボキサミド類；イソフルシプラム(isoflucypram)等のN-シクロプロピル-N-ベンジルピラゾールカルボキサミド類；ピジフルメトフェン（pydiflumetofen）等のN-メトキシ(フェニルエチル)ピラゾールカルボキサミド類；ボスカリド（boscalid）等のピリジンカルボキサミド類；ピラジフルミド（pyraziflumide）等のピラジンカルボキサミド類等が挙げられる。 Respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2)
Examples of respiratory chain complex II (succinate dehydrogenase) inhibitors include phenylbenzamides such as benodanil, flutolanil, mepronil and the like; phenyloxoethylthiophene amides such as isofetamide and the like Pyridinylethyl benzamides such as fluopyram; furancarboxamides such as fenfuram; oxathiin carboxamides such as carboxin, oxicarboxin etc .; thifluzamide etc Thiazolecarboxamides; benzobindiflupyr (benzovindiflupyr), bixafen (bixafen), fluindapyr (fluindapyr), fluxapyroxad (fluxapyroxad), furametopyr (furametpyr), isopyrazam, penflufen, penflufen, isopyrazam Pyrazole 4-carboxamides such as isopyrazam and sedaxane; N-cyclopropyl-N-benzylpyrazole carboxamides such as isoflucypram; N-methoxy such as pydiflumethofen (Phenylethyl) pyrazole carboxamides; pyridine carboxamides such as boscalid; pyrazine carboxamides such as pyraziflumide etc.
　呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）
　呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤としては、例えば、アゾキシストロビン（azoxystrobin）、ピコキシストロビン（picoxystrobin）、エノキサストロビン（enoxastrobin）、ピラオキシストロビン（pyraoxystrobin）、クモキシストロビン（coumoxystrobin）、フルフェノキシストロビン（flufenoxystrobin）等のメトキシアクリレート類；マンデストロビン（mandestrobin）等のメトキシアセトアミド類；オリサストロビン（orysastrobin）、ジモキシストロビン（dimoxystrobin）、メトミノストロビン（metominostrobin）、フェナミンストロビン（fenaminstrobin）等のオキシイミノアセトアミド類；ピラクロストロビン（pyraclostrobin）、ピラメトストロビン（pyrametostrobin）、トリクロピリカルブ（triclopyricarb）等のメトキシカーバメート類；クレソキシムメチル（kresoxim-methyl）、トリフロキシストロビン（trifloxystrobin）等のオキシイミノ酢酸類；ピリベンカルブ（pyribencarb）等のベンジルカーバメート類；ファモキサドン（famoxadone）等のオキサゾリジンジオン類；フェナミドン（fenamidone）等のイミダゾリノン類；フルオキサストロビン（fluoxastrobin）等のジヒドロジオキサジン類等が挙げられる。 Respiratory chain complex III (Ubiquinol oxidase, Qo site) inhibitor (C3)
As a respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor, for example, azoxystrobin (azoxystrobin), picoxystrobin (picoxystrobin), enoxastrobin (enoxastrobin), pyroxystrobin (pyraoxystrobin), Methoxy acrylates such as coumoxystrobin, fluphenoxystrobin, etc .; methoxyacetamides such as mandestrobin, etc .; orysastrobin (orysastrobin), dimoxystrobin (dimoxystrobin), metominostrobin ( Metominosstrobin), oxaminamides such as phenaminstrobin (fenaminstrobin); Pyraclostrobin, pyrametostrobin, methoxycarbamates such as triclopyricarb (cresoximmeth) (Kresoxim-methyl), oximino acid such as trifloxystrobin; benzyl carbamates such as pyribencarb; oxazolidinediones such as famoxadone; imidazolinones such as fenamidone; Dihydrodioxazines such as oxastrobin (fluoxastrobin) and the like can be mentioned.
　呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）
　呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤としては、例えば、シアゾファミド（cyazofamid）等のシアノイミダゾール；アミスルブロム（amisulbrom）等のスルファモイルトリアゾール；フェンピコキサミド(fenpicoxamid)等のピコリナミド類；フェリムゾン等が挙げられる。 Respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4)
As a respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor, for example, cyanoimidazole such as cyazofamid (cyazofamid); sulfamoyltriazole such as amisulbrom; and picolinamides such as fenpicoxamide And Ferimsone etc. may be mentioned.
　酸化的リン酸化における脱共役剤（Ｃ５）
　酸化的リン酸化における脱共役剤としては、例えば、フルアジナム（fluazinam）等の2,6-ジニトロアニリン類；メプチルジノカップ（meptyl dinocap）、ビナパクリル（binapacryl）等のジニトロフェニルクロトン酸類；フェリムゾン（ferimzone）等のピリミジノンヒドラゾン類等が挙げられる。 Uncoupling agent (C5) in oxidative phosphorylation
Examples of uncoupling agents in oxidative phosphorylation include 2,6-dinitroanilines such as fluazinam; dinitrophenyl crotonic acids such as meptyl dinocap; binapacryl; ferimzone Etc.), and the like.
　ＡＴＰ合成における酸化的リン酸化の阻害剤（Ｃ６）
　ＡＴＰ合成における酸化的リン酸化の阻害剤としては、例えば、フェンチン酢酸塩（fentin acetate）、塩化フェンチン（fentin chloride）、水酸化フェンチン（fentin hydroxide）等のトリフェニルスズ化合物等が挙げられる。 Inhibitors of oxidative phosphorylation in ATP synthesis (C6)
Examples of inhibitors of oxidative phosphorylation in ATP synthesis include triphenyltin compounds such as fentin acetate, fentin chloride, fentin hydroxide and the like.
　ＡＴＰ生成阻害剤（Ｃ７）
　ＡＴＰ生成阻害剤としては、例えば、シルチオファム（silthiofam）等のチオフェンカルボキサミド類等が挙げられる。 ATP production inhibitor (C7)
Examples of the ATP production inhibitor include thiophenecarboxamides such as silthiofam and the like.
　呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）
　呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤としては、例えば、アメトクトラジン（ametoctradin）等のトリアゾロピリミジルアミン等が挙げられる。 Respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8)
As a respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor, for example, triazolopyrimidylamine such as ametoctradin and the like, and the like can be mentioned.
　＜Ｄグループ＞
　Ｄグループ（アミノ酸及び蛋白質生合成）としては、例えば、メチオニン生合成阻害剤（Ｄ１）、タンパク質合成阻害剤（Ｄ２、３、４、５）等が挙げられる。 <D group>
Examples of D group (amino acid and protein biosynthesis) include methionine biosynthesis inhibitor (D1), protein synthesis inhibitor (D2, 3, 4, 5) and the like.
　メチオニン生合成阻害剤（Ｄ１）
　メチオニン生合成阻害剤としては、例えば、シプロジニル（cyprodinil）、メパニピリム（mepanipyrim）、ピリメタニル（pyrimethanil）等のアニリノピリミジン類等が挙げられる。 Methionine biosynthesis inhibitor (D1)
Examples of methionine biosynthesis inhibitors include anilinopyrimidines such as cyprodinil, mepanipyrim, pyrimethanil and the like.
　タンパク質合成阻害剤（Ｄ２）
　タンパク質合成阻害剤としては、例えば、ブラスチシジンＳ（blasticidin-S）等のエノピラヌロン酸抗生物質等が挙げられる。 Protein synthesis inhibitor (D2)
Examples of protein synthesis inhibitors include enopyranuronic acid antibiotics such as blasticidin S (blasticidin-S) and the like.
　タンパク質合成阻害剤（Ｄ３）
　タンパク質合成阻害剤としては、例えば、カスガマイシン（kasugamycin）等のヘキソピラノシル抗生物質等が挙げられる。 Protein synthesis inhibitor (D3)
Examples of protein synthesis inhibitors include hexopyranosyl antibiotics such as kasugamycin and the like.
　タンパク質合成阻害剤（Ｄ４）
　タンパク質合成阻害剤としては、例えば、ストレプトマイシン（streptmycin）等のグルコピラノシル抗生物質等が挙げられる。 Protein synthesis inhibitor (D4)
Examples of protein synthesis inhibitors include glucopyranosyl antibiotics such as streptomycin, and the like.
　タンパク質合成阻害剤（Ｄ５）
　タンパク質合成阻害剤としては、例えば、オキシテトラサイクリン（oxytetracycline）等のテトラサイクリン抗生物質が挙げられる。 Protein synthesis inhibitor (D5)
Protein synthesis inhibitors include, for example, tetracycline antibiotics such as oxytetracycline.
　＜Ｅグループ＞
　Ｅグループ（シグナル伝達）としては、例えば、メカニズム不明のシグナル伝達阻害剤（Ｅ１）、浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ（os-2、HOG1）（Ｅ２）、浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ阻害剤（os-1、Daf1）（Ｅ３）等が挙げられる。 <E group>
As group E (signaling), for example, signal transduction inhibitor with unknown mechanism (E1), MAP · histidine kinase (os-2, HOG1) (E2) in osmotic signaling, MAP · histidine in osmotic signaling Kinase inhibitors (os-1, Daf1) (E3) and the like can be mentioned.
　メカニズム不明のシグナル伝達阻害剤（Ｅ１）
　メカニズム不明のシグナル伝達阻害剤としては、例えば、キノキシフェン（quinoxyfen）等のアリルオキシキノリン；プロキナジド（proquinazid）等のキナゾリノン等が挙げられる。 Signal transduction inhibitor of unknown mechanism (E1)
Examples of signal transduction inhibitors with unknown mechanisms include allyloxyquinolines such as quinoxyfen and the like; quinazolinones such as proquinazid and the like.
　浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ（os-2、HOG1）（Ｅ２）
　浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ阻害剤（os-2、HOG1）としては、例えば、フェンピクロニル（fenpiclonil）、フルジオキソニル（fludioxonil）等のフェニルピロール類等が挙げられる。 MAP · Histidine kinase (os-2, HOG1) (E2) in osmotic signaling
Examples of MAP / histidine kinase inhibitors (os-2, HOG1) in osmotic signaling include phenylpyrroles such as fenpiclonil, fludioxonil, and the like.
　浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ阻害剤（os-1、Daf1）（Ｅ３）
　浸透圧シグナル伝達におけるＭＡＰ・ヒスチジンキナーゼ阻害剤（os-1、Daf1）としては、例えば、クロゾリネート（chlozolinate）、プロシミドン（procymidone）、イソプロジオン（isoprodione）、ビンクロゾリン（vinclozolin）、ジメタクロン（dimethachlone）等のジカルボキシイミド類等が挙げられる。 MAP and histidine kinase inhibitors (os-1, Daf1) (E3) in osmotic signaling
As MAP and histidine kinase inhibitors (os-1, Daf1) in osmotic signaling, for example, clozolinate (chlozolinate), procymidone (procymone), isoprodione (isoprodione), vinclozolin, vinclozolin, dimethaclone, etc. Dicarboximides and the like can be mentioned.
　＜Ｆグループ＞
　Ｆグループ（脂質生合成又は輸送／細胞膜の構造又は機能）としては、例えば、リン脂質生合成のメチルトランスフェラーゼ阻害剤（Ｆ２）、脂質の過酸化阻害剤（Ｆ３）、細胞膜浸透性の脂肪酸（Ｆ４）、病原菌細胞膜の微生物攪乱（Ｆ６）、細胞膜の攪乱剤（Ｆ７）、エルゴステロール結合剤（Ｆ８）、脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）等が挙げられる。 <F group>
Examples of the F group (structure or function of lipid biosynthesis or transport / cell membrane) include methyltransferase inhibitors of phospholipid biosynthesis (F2), lipid peroxidation inhibitors (F3), cell membrane-permeant fatty acids (F4) ), Microbial disturbance of pathogen cell membrane (F6), cell membrane disrupter (F7), ergosterol binder (F8), lipid homeostasis, transfer, storage inhibitor (F9) and the like.
　リン脂質生合成のメチルトランスフェラーゼ阻害剤（Ｆ２）
　リン脂質生合成のメチルトランスフェラーゼ阻害剤としては、例えば、ピラゾフォス（pyrazophos）、エジフェンフォス（edifenphos）、イプロベンフォス（iprobenfos）等のホスホロチオレート類；イソプロチオラン（iso-prothiolane）等のジチオラン類等が挙げられる。 Methyltransferase inhibitors (F2) of phospholipid biosynthesis
Examples of methyltransferase inhibitors for phospholipid biosynthesis include phosphorothiolates such as pyrazophos, edifenphos, iprobenfos and the like; dithiolanes such as isoprothiolane and the like Etc.
　脂質の過酸化阻害剤（Ｆ３）
　脂質の過酸化阻害剤としては、例えば、テクナゼン（tecnazen）、ジクロラン（dicloran）、キントゼン（quintozene）、ビフェニル（biphenyl）、トルクロフォスメチル（tolclofos-methyl）、クロロネブ（chloroneb）等の芳香族炭化水素；エトリジアゾール（etridiazole）等の1,2,4-チアジアゾール類等が挙げられる。 Lipid Peroxidation Inhibitor (F3)
Examples of lipid peroxidation inhibitors include aromatic hydrocarbons such as tecnazen, dichloran, quintozene, biphenyl, tolclofos-methyl, chloroneb, etc. And 1,2,4-thiadiazoles such as etridiazole.
　細胞膜浸透性の脂肪酸（Ｆ４）
　細胞膜浸透性の脂肪酸としては、例えば、プロチオカルブ（prothiocarb）、イオドカルブ（iodocarb）、プロパモカルブ（propamocarb）、プロパモカルブ塩酸塩（propamocarb hydrochloride salt）等のカーバメート類等が挙げられる。 Cell membrane permeable fatty acid (F4)
Examples of the cell membrane permeable fatty acids include carbamates such as prothiocarb, iodocarb, propamocarb, propamocarb hydrochloride salt and the like.
　病原菌細胞膜の微生物攪乱（Ｆ６）
　病原菌細胞膜の微生物攪乱としては、例えば、Bacillus amyloliquefaciens（synonym Bacillus subtilis）strains：QSR713 FZB24 MBI600 D747等のBacillus属及び産生された殺菌性リポペプチド類が挙げられる。 Microbial perturbation of pathogen cell membranes (F6)
Microbial perturbations of pathogen cell membranes include, for example, Bacillus genus such as Bacillus amyloliquefaciens (synonym Bacillus subtilis) strains: QSR 713 FZB24 MBI 600 D747 and produced bactericidal lipopeptides.
　細胞膜の攪乱剤（Ｆ７）
　細胞膜の攪乱剤としては、例えば、オイゲノール（eugenol）、ゲラニオール（geraniol）、チモール（thymol）のようなテルペノイド化合物や、これらの化合物を含む植物抽出液、精油等のテルペン炭化水素類とテルペンアルコール類とテルペンフェノール類等が挙げられる。 Cell membrane disruptor (F7)
As disrupters of cell membranes, for example, terpenoid compounds such as eugenol (eugenol), geraniol (geraniol), thymol (thymol), plant extracts containing these compounds, terpene hydrocarbons such as essential oils, and terpene alcohols And terpene phenols.
　エルゴステロール結合剤（Ｆ８）
　エルゴステロール結合剤としては、例えば、ナタマイシン（natamycin）等の放線菌Streptomyces natalensis又はS. chattanoogensisが産生する両性親媒マクロライド系抗真菌性抗生物質等が挙げられる。 Ergosterol binder (F8)
Examples of the ergosterol binding agent include amphoteric amphiphilic macrolide antifungal antibiotics produced by actinomycetes Streptomyces natalensis or S. chattanoogensis such as natamycin (natamycin).
　脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）
　脂質の恒常性、転移、貯蔵の阻害剤としては、例えば、オキサチアピプロリン（oxathiapiproline）等のピペリジニルチアゾールイソオキサゾリン類等が挙げられる。 Inhibitors of lipid homeostasis, metastasis, storage (F9)
Examples of the inhibitor of lipid homeostasis, transfer and storage include piperidinylthiazole isoxazolines such as oxathiapiproline and the like.
　＜Ｇグループ＞
　Ｇグループ（細胞膜のステロール生合成）としては、例えば、ステロール生合成におけるＣ１４位の脱メチル化の阻害剤（Ｇ１）、ステロール生合成におけるΔ１４レダクターゼとΔ８→Δ７イソメラーゼ（Ｇ２）、Ｃ４位の脱メチル化における３－ケトレダクターゼ阻害剤（Ｇ３）、ステロール生合成におけるスクアレンエポキシダーゼの阻害剤（Ｇ４）等が挙げられる。 <G group>
As the G group (sterol biosynthesis of cell membrane), for example, inhibitors of demethylation at C14 position in sterol biosynthesis (G1), Δ14 reductase and Δ8 → Δ7 isomerase (G2) in sterol biosynthesis, and C4 position elimination Examples thereof include 3-ketoreductase inhibitors (G3) for methylation, inhibitors of squalene epoxidase (G4) for sterol biosynthesis, and the like.
　ステロール生合成におけるＣ１４位の脱メチル化の阻害剤（Ｇ１）
　ステロール生合成におけるＣ１４位の脱メチル化の阻害剤としては、例えば、アザコナゾール（azaconazole）、ビテルタノール（bitertanol）、ブロムコナゾール（bromuconazole）、シプロコナゾール（cyproconazole）、ジフェノコナゾール（difenoconazole）、ジニコナゾール（diniconazole）、エポキシコナゾール（epoxiconazole）、エタコナゾール（etaconazole）、フェンブコナゾール（fenbuconazole）、フルキンコナゾール（fluquinconazole）、フルシアゾール（flusilazole）、フルトリアホール（flutriafol）、ヘキサコナゾール（hexaconazole）、イミベンコナゾール（imibenzonazole）、イプコナゾール（ipconazole）、メトコナゾール（metconazole）、ミクロブタニル（miclobutanil）、ペンコナゾール（penconazole）、プロピコナゾール（propiconazole）、シメコナゾール（simeconazole）、テブコナゾール（tebuconazole）、テトラコナゾール（tetraconazole）、トリアジメホン（triadimefon）、トリアジメノール（triadimenol）、トリチコナゾール（triticonazole）等のトリアゾール類；プロチオコナゾール（prothioconazole）等のトリアゾリンチオン類；トリホリン（triforine）等のピペラジン類、ピリフェノックス（pyrifenox）、ピリソキサゾール（pyrisoxazole）等のピリジン類；ヌアリモール（nuarimol）、フェナリモール（fenarimol）等のピリミジン類；イマザリル（imazalil）、トリフルミゾール（triflumizole）、ペフラゾエート（pefurazoate）、オキシポコナゾール（oxpoconazole）、オキシポコナゾールフマル酸塩（oxpoconazole fumarate）、プロクロラズ（prochloraz）等のイミダゾール類等が挙げられる。 Inhibitors of C14 demethylation in sterol biosynthesis (G1)
Examples of inhibitors of demethylation at C14 position in sterol biosynthesis include azaconazole (azaconazole), bitertanol (bitertanol), bromuconazole (bromuconazole), cyproconazole (cyproconazole), difenoconazole (difenoconazole), diniconazole (diniconazole) ), Epoxiconazole (epoxiconazole), etaconazole (etaconazole), fenbuconazole (fenbuconazole), fluquinconazole (fluquinconazole), flusiazole (flusilazole), flutriahol (flutriafol), hexaconazole (hexaconazole), imibenconazole (Imibenzonazole), ipconazole (ipconazole), metconazole (metconazole), microbutanil (miclobutanil), penconazole (penconazole), propiconazole (propiconazole), simeconazole (simeconazole), tebuko Triazoles such as nazole (tebuconazole), tetraconazole (tetraconazole), triadimefon (triadimefon), triadimenol (triadimenol), triticonazole (triticonazole), etc .; Triazolinthiones such as prothioconazole (prothioconazole); piperazines such as triforine), pyridines such as pyrifenox, pyrisoxazole etc .; pyrimidines such as nuarimol (nuarimol), phenarimol (fenarimol), etc .; imazalil (imazalil), triflumizole, peflazoate And imidazoles such as (pefurazoate), oxypoconazole (oxpoconazole), oxypoconazole fumarate (oxpoconazole fumarate), prochloraz (prochloraz) and the like.
　ステロール生合成におけるΔ１４レダクターゼとΔ８→Δ７イソメラーゼ（Ｇ２）
　ステロール生合成におけるΔ１４レダクターゼとΔ８→Δ７イソメラーゼとしては、例えば、アルジモルフ（aldimorph）、フェンプロピモルフ（fenpropimorph）、トリデモルフ（tridemorph）、ドデモルフ（dodemorph）等のモルフォリン類；フェンプロピジン（fenpropidin）、ピペラリン（piperalin）等のピペリジン類；スピロキサミン（spiroxamine）等のスピロケタールアミン類等が挙げられる。 Δ14 Reductase and Δ8 → Δ7 Isomerase (G2) in Sterol Biosynthesis
Examples of Δ14 reductase and Δ8 → Δ7 isomerase in sterol biosynthesis include morpholinins such as aldimorph, fenpropimorph, tridemorph and dodemorph; fenpropidin, And piperidines such as piperalin; spiroketal amines such as spiroxamine and the like.
　Ｃ４位の脱メチル化における３－ケトレダクターゼ阻害剤（Ｇ３）
　Ｃ４位の脱メチル化における３－ケトレダクターゼ阻害剤としては、例えば、フェンヘキサミド（fenhexamid）等のヒドロキシアニリド類；フェンピラザミン（fenpyrazamine）等のアミノピラゾリノン等が挙げられる。 3-ketoreductase inhibitors (G3) in C4 demethylation
Examples of 3-ketoreductase inhibitors in demethylation at the C4 position include hydroxyanilides such as fenhexamid; aminopyrazolinones such as fenpyrazamine.
　ステロール生合成におけるスクアレンエポキシダーゼの阻害剤（Ｇ４）
　ステロール生合成におけるスクアレンエポキシダーゼの阻害剤としては、例えば、ナフチフィン（naftifine）、テルビナフィン（terbinafine）等のチオカーバメート類；ピリブチカルブ（pyributicarb）等のチオカーバメート類等が挙げられる。 Inhibitors of squalene epoxidase in sterol biosynthesis (G4)
Examples of inhibitors of squalene epoxidase in sterol biosynthesis include thiocarbamates such as naftifine and terbinafine; and thiocarbamates such as pyributicarb.
　＜Ｈグループ＞
　Ｈグループ（細胞壁生合成）としては、例えば、キチン生合成阻害剤（Ｈ４）、セルロース合成阻害剤（Ｈ５）等が挙げられる。 <H group>
Examples of the H group (cell wall biosynthesis) include chitin biosynthesis inhibitors (H4) and cellulose synthesis inhibitors (H5).
　キチン生合成阻害剤（Ｈ４）
　キチン生合成阻害剤としては、例えば、ポリオキシンＢ（polyoxine B）等のペプチジルピリミジンヌクレオシド等が挙げられる。 Chitin biosynthesis inhibitor (H4)
Examples of chitin biosynthesis inhibitors include peptidyl pyrimidine nucleosides such as polyoxin B (polyoxine B) and the like.
　セルロース合成阻害剤（Ｈ５）
　セルロース合成阻害剤としては、例えば、ジメトモルフ（dimethomorph）、フルモルフ（flumorph）、ピリモルフ（pyrimorph）等の桂皮酸アミド類；マンジプロパミド（mandipropamide）等のマンデル酸アミド類；イプロバリカルブ（iprovalicarb）、ベンチアバリカルブ（benthiavalicarb）、バリフェナカルブ（valifenalate）等のバリンアミドカーバメート類等が挙げられる。 Cellulose synthesis inhibitor (H5)
Cellulose synthesis inhibitors include, for example, dimethomorph, flumorph, cinnamic acid amides such as pyrimorph, etc .; mandelic acid amides such as mandipropamide, etc .; iprovalicarb; (Benthiavalicarb), valine amide carbamates such as valifenacarb (valifenalate) and the like.
　＜Ｉグループ＞
　Ｉグループ（細胞壁のメラニン生合成）としては、例えば、メラニン生合成における還元酵素阻害剤（Ｉ１）、メラニン生合成における脱水酵素阻害（Ｉ２）、メラニン生合成におけるポリケチド合成阻害（Ｉ３）等が挙げられる。 <I group>
Examples of group I (melanin biosynthesis in cell walls) include reductase inhibitor (I1) in melanin biosynthesis, dehydratase inhibition in melanin biosynthesis (I2), polyketide synthesis inhibition in melanin biosynthesis (I3), etc. Be
　メラニン生合成における還元酵素阻害剤（Ｉ１）
　メラニン生合成における還元酵素阻害剤としては、例えば、フサライド（fthalide）等のイソベンゾフラノン；ピロキロン（pyroquilon）等のピロロキノリノン；トリシクラゾール（tricyclazole）等のトリアゾロベンゾチアゾール等が挙げられる。 Reductase inhibitors in melanin biosynthesis (I1)
Examples of reductase inhibitors in melanin biosynthesis include isobenzofuranones such as phthalide; pyrroloquinolinones such as pyroquilon; and triazolobenzothiazoles such as tricyclazole.
　メラニン生合成における脱水酵素阻害（Ｉ２）
　メラニン生合成における脱水酵素阻害としては、例えば、ジクロシメット（diclocymet）等のカルボキサミド；カルプロパミド（carpropamid）等のシクロプロパンカルボキサミド；フェノキサニル（fenoxanil）等のプロピオンアミド等が挙げられる。 Dehydration enzyme inhibition in melanin biosynthesis (I2)
Examples of dehydratase inhibition in melanin biosynthesis include carboxamides such as diclocymet; cyclopropanecarboxamides such as carpropamide; propionamides such as fenoxanil and the like.
　メラニン生合成におけるポリケチド合成阻害剤（Ｉ３）
　メラニン生合成におけるポリケチド合成阻害剤としては、例えば、トルプロカルブ（tolprocarb）等のトリフルオロエチルカーバメート等が挙げられる。 Polyketide synthesis inhibitor in melanin biosynthesis (I3)
Examples of polyketide synthesis inhibitors in melanin biosynthesis include trifluoroethyl carbamates such as tolprocarb, and the like.
　＜Ｍグループ＞
　多作用点を標的とする化合物（Ｍ）
　多作用点を標的とする化合物（Ｍ）としては、例えば、銅化合物（Ｍ１）、硫黄系化合物（Ｍ２）、ジチオカーバメート系化合物及びその関連化合物（Ｍ３）、フタルイミド系化合物（Ｍ４）、クロロニトリル系化合物（Ｍ５）、サルファミド系化合物（Ｍ６）、ビスグアニジン系化合物（Ｍ７）、トリアジン系化合物（Ｍ８）、アントラキノン系化合物（Ｍ９）、キノキサリン系化合物（Ｍ１０）、マレイミド系化合物（Ｍ１１）等が挙げられる。多作用点を標的とする化合物（Ｍ）として好ましくは、Ｍ１、Ｍ３及びＭ５である。 <M group>
Compounds that target multiple action points (M)
Examples of compounds (M) targeted to multiple action points include copper compounds (M1), sulfur compounds (M2), dithiocarbamate compounds and their related compounds (M3), phthalimide compounds (M4), chloronitriles Compounds (M5), sulfamide compounds (M6), bisguanidine compounds (M7), triazine compounds (M8), anthraquinone compounds (M9), quinoxaline compounds (M10), maleimide compounds (M11), etc. It can be mentioned. Preferred compounds (M) targeted for multiple action points are M1, M3 and M5.
　銅化合物（Ｍ１）
　銅化合物としては、例えば、ＤＢＥＤＣ、塩基性塩化銅（copper oxychloride）、塩基性硫酸銅（copper sulfate）、水酸化第二銅（copper hydroxide）、ノニルフェノールスルホン酸銅（copper nonylphenol sulfonate）等の無機化合物（硫黄を含まない）等が挙げられる。 Copper compound (M1)
As the copper compound, for example, inorganic compounds such as DBEDC, basic copper chloride (copper oxychloride), basic copper sulfate (copper sulfate), copper hydroxide (copper hydroxide), copper nonylphenol sulfonate (copper nonylphenol sulfonate), etc. (Does not contain sulfur) and the like.
　硫黄系化合物（Ｍ２）
　硫黄系化合物としては、例えば、硫黄（sulpher）、石灰硫黄合剤（lime sulfur）等の無機化合物（銅を含まない）等が挙げられる。 Sulfur based compounds (M2)
As a sulfur type compound, inorganic compounds (it does not contain copper), such as sulfur (sulfur) and a lime sulfur compound (lime sulfur), etc. are mentioned, for example.
　ジチオカーバメート系化合物及びその関連化合物（Ｍ３）
　ジチオカーバメート系化合物及びその関連化合物としては、例えば、フェルバム（ferbam）、メチラム（metiram）、チラム（thiram）、マンゼブ（mancozeb）、プロピネブ（propineb）、ジネブ（zineb）、亜鉛チアゾール（zinc thiazole）、マネブ（maneb）ジラム（ziram）等のジチオカーバメート類及び類縁体等が挙げられる。 Dithiocarbamate compounds and related compounds (M3)
Examples of dithiocarbamate compounds and their related compounds include ferbam, metiram, thiram, manzeb (mancozeb), propineb (propineb), zineb (zineb), zinc thiazole (zinc thiazole), and the like. And dithiocarbamates and analogs such as maneb ziram.
　フタルイミド系化合物（Ｍ４）
　フタルイミド系化合物としては、例えば、キャプタン（captan）、キャプタホール（captafol）、ホルペット（folpet）等のフタルイミド類等が挙げられる。 Phthalimide compound (M4)
Examples of phthalimide compounds include phthalimides such as captan, captafol, and folpet.
　クロロニトリル系化合物（Ｍ５）
　クロロニトリル系化合物としては、例えば、クロロタロニル（chlorothalonil）等のクロロニトリル類(フタロニトリル類)等が挙げられる。 Chloronitrile compound (M5)
Examples of the chloronitrile compounds include chloronitriles (phthalonitriles) such as chlorothalonil and the like.
　サルファミド系化合物（Ｍ６）
　サルファミド系化合物としては、例えば、ジクロフルアニド（dichlofluanid）、トリルフルアニド（tolylfluanid）等のスルファミド類等が挙げられる。 Sulfamide compounds (M6)
Examples of the sulfamide compounds include sulfamides such as dichlofluanid and tolylfluanid.
　ビスグアニジン系化合物（Ｍ７）
　ビスグアニジン系化合物としては、例えば、グアザチン（guazatine）、イミノクタジン（iminoctadine）等のビスグアニジン類等が挙げられる。 Bisguanidine compound (M7)
Examples of the bisguanidine compounds include bisguanidines such as guazatine and iminoctadine.
　トリアジン系化合物（Ｍ８）
　トリアジン系化合物としては、例えば、アニラジン（anilazine）等のトリアジン類等が挙げられる。 Triazine-based compounds (M8)
As a triazine type compound, triazines, such as anilazine (anilazine), etc. are mentioned, for example.
　アントラキノン系化合物（Ｍ９）
　アントラキノン系化合物としては、例えば、ジチアノン（dithianon）等のキノン類(アントラキノン類)等が挙げられる。 Anthraquinone compound (M9)
Examples of anthraquinone compounds include quinones (anthraquinones) such as dithianon (dithianon) and the like.
　キノキサリン系化合物（Ｍ１０）
　キノキサリン系化合物としては、例えば、キノメチオナット（chinomethionat）、キノメチオネート（quinomethionate）等のキノキサリン類等が挙げられる。 Quinoxaline compounds (M10)
Examples of the quinoxaline compound include quinoxalines such as quinomethionate and quinomethionate.
　マレイミド系化合物（Ｍ１１）
　マレイミド系化合物としては、例えば、フルオロイミド（fluoroimide）等のマレイミド系化合物（Ｍ１１）等が挙げられる。 Maleimide compound (M11)
Examples of maleimide compounds include maleimide compounds (M11) such as fluoroimide.
　マレイミド系化合物（Ｍ１２）
　チオカーバメート化合物としては、例えば、メタスルフォカルブ（methasulfocarb）等のチオカーバメート等が挙げられる。 Maleimide compound (M12)
Examples of the thiocarbamate compound include thiocarbamates such as metasulfocarb and the like.
　＜Ｐグループ＞
　Ｐグループ（宿主植物の抵抗生誘導剤）としては、例えば、サリチル酸経路を刺激する抵抗性誘導剤（Ｐ１）、宿主植物の抵抗性誘導剤（Ｐ２、３、４）、宿主植物の抵抗性を誘導する植物抽出液（Ｐ５）、宿主植物の抵抗性を誘導する微生物及び微生物製剤（Ｐ６）等が挙げられる。 <P group>
As P group (resistance plant life inducer of host plant), for example, resistance inducer which stimulates salicylic acid pathway (P1), resistance plant inducer of host plant (P2, 3, 4), resistance of host plant Plant extracts (P5) to be induced, microorganisms and microorganism preparations (P6) to induce resistance of host plants, and the like can be mentioned.
　サリチル酸経路を刺激する抵抗性誘導剤（Ｐ１）
　サリチル酸経路を刺激する抵抗性誘導剤（サリチル酸シグナル伝達）としては、例えば、アシベンゾラル－Ｓ－メチル（acibenzolar-S-methyl）等のベンゾチアジアゾールＢＴＨ等が挙げられる。 Resistance inducer (P1) which stimulates the salicylic acid pathway
Examples of resistance inducers (salicylic acid signaling) that stimulate the salicylic acid pathway include benzothiadiazole BTH such as acibenzolar-S-methyl.
　宿主植物の抵抗性誘導剤（Ｐ２）
　宿主植物の抵抗性誘導剤（サリチル酸シグナル伝達）としては、例えば、プロベナゾール（probenazole）等のベンゾイソチアゾール等が挙げられる。 Host plant resistance inducer (P2)
Examples of resistance inducers for host plants (salicylic acid signaling) include benzisothiazoles such as probenazole and the like.
　宿主植物の抵抗性誘導剤（Ｐ３）
　宿主植物の抵抗性誘導剤（サリチル酸シグナル伝達）としては、例えば、イソチアニル（isothianil）、チアジニル（thiadinil）等のチアジアゾールカルボキサミド等が挙げられる。 Host plant resistance inducer (P3)
Examples of resistance inducers for host plants (salicylic acid signaling) include thiadiazole carboxamides such as isothianyl, thiazinyl, and the like.
　宿主植物の抵抗性誘導剤（Ｐ４）
　宿主植物の抵抗性誘導剤（多糖類エリシター、天然物）としては、例えば、ラミナリン（laminarin）等の多糖類等が挙げられる。 Host plant resistance inducer (P4)
Examples of resistance inducers for host plants (polysaccharide elicitors, natural products) include polysaccharides such as laminarin, and the like.
　宿主植物の抵抗性を誘導する植物抽出液（Ｐ５）
　宿主植物の抵抗性を誘導する植物抽出液（アントラキノンエリシター、植物抽出物）としては、例えば、Reynoutria sachalinensis（Giant knotweed）のような、Reynoutria属（オオイタドリ）の植物の抽出液、精油等が挙げられる。 Plant extract (P5) which induces resistance of host plant
Examples of plant extracts (anthraquinone elicitors, plant extracts) that induce resistance of host plants include extracts of plants of the genus Reynoutria (Oitadori), such as Reynoutria sachalinensis (Giant knotweed), essential oils, etc. .
　宿主植物の抵抗性を誘導する微生物及び微生物製剤（Ｐ６）
　宿主植物の抵抗性を誘導する微生物及び微生物製剤（微生物エリシター、微生物）としては、例えば、Bacillus mycoides又はその製剤等のバチルス・セレウス菌等が挙げられる。 Microorganisms and microbial preparations that induce resistance of host plants (P6)
Examples of microorganisms and microorganism preparations (microbe elicitors, microorganisms) that induce resistance of host plants include Bacillus cereus such as Bacillus mycoides or preparations thereof.
　宿主植物の抵抗性を誘導剤（Ｐ７）
　宿主植物の抵抗性誘導剤（ホスホナート）としては、例えば、ホセチル(fosetyl)、ホセチルアルミニウム（fosetyl-al）等のエチルホスホナート類；亜リン酸（phosphorous acid）、亜リン酸塩等が挙げられる。 Inducers of host plant resistance (P7)
Examples of resistance inducers (phosphonates) of host plants include ethylphosphonates such as fosetyl, fosetyl-al, etc .; phosphorous acids, phosphites, etc. .
　その他、作用機序が不明の化合物（グループ：Unknown mode of action）（Ｕ）
　その他、作用機序が不明の化合物（グループ：Unknown mode of action）として、シモキサニル（cymoxanil）等のシアノアセトアミドオキシム；テクロフタラム（teclofthalam）等のフタラミン酸類；シフルフェナミド（cyflufenamide）等のフェニルアセトアミド；フルチアニル（fluthianil）等のシアノメチレンチアゾリジン；テブフロキン（tebufloquin）等の酢酸4-キノリン；バリダマイシン（validamycin）等のグルコピラノシル抗生物質；トリアゾキシド（triazoxide）等のベンゾトリアジン類；フルスルファミド（flusulfamide）等のベンゼンスルホンアミド類；ジクロメジン（diclomezine）等のピリダジノン類；ドジン（dodine）等のグアニジン類；ピカルブトラゾックス（picarbutrazox）等のテトラゾリルオキシム等が挙げられる。 Other compounds with unknown mechanism of action (group: Unknown mode of action) (U)
In addition, as a compound with unknown mechanism of action (group: Unknown mode of action), cyanoacetamide oxime such as cymoxanil; phthalamic acid such as teclofthalam; phenylacetamide such as cyflufenamide etc .; fluthianil (fluthianil) B.) Cyanomethylene thiazolidines; acetic acid 4-quinoline such as tebufloquin; glucopyranosyl antibiotics such as validamycin; benzotriazines such as triazoloxide; benzenesulfonamides such as flusulfamide; dichromedines Pyridazinones such as (diclomezine); guanidines such as dodine; tetrazolyl oxime such as picarbutrazox and the like.
　中でもより好ましい殺菌剤は、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩及びシモキサニルである。 Among them, more preferable bactericidal agents are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim-methyl, picoxystrobin, ciazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxospoco Nazole fumaric acid salt, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, fluopicolide, propamocarb hydrochloride, fosetyl aluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt and shimoxanyl.
　本発明においては、ニトロフェノール化合物と、殺菌活性化合物のいずれか１つ以上とを併用することを必須とする。ニトロフェノール化合物と殺菌活性化合物とを併用することにより、農園芸病原菌に対して顕著な防除効果が発現される。相乗的殺菌剤組成物とは、相乗的な防除効果（相乗効果）を有する殺菌剤組成物を意味する。 In the present invention, it is essential to use the nitrophenol compound and any one or more of the bactericidal compounds in combination. By using a nitrophenol compound and a bactericidal compound in combination, a remarkable controlling effect on agricultural and horticultural pathogens is exhibited. By synergistic bactericidal composition is meant a bactericidal composition having a synergistic control effect (synergistic effect).
　本発明においては、一般式（１）のニトロフェノール化合物１００重量部に対して、殺菌活性化合物を通常０．１～２００００重量部、好ましくは１～１００００重量部、より好ましくは５～５０００重量部配合する。 In the present invention, the bactericidally active compound is usually 0.1 to 20000 parts by weight, preferably 1 to 10000 parts by weight, more preferably 5 to 5000 parts by weight based on 100 parts by weight of the nitrophenol compound of the general formula (1). Mix.
　本発明組成物には、他の成分を加えず、ニトロフェノール化合物と殺菌活性化合物を配合するだけでよいが、通常は、固体担体、液体担体、ガス状担体（噴射剤）を混合し、必要に応じて界面活性剤、その他の製剤用補助剤を添加して、通常の製剤化方法に従い、油剤、乳剤、水和剤、フロアブル剤、粒剤、粉剤、エアゾール、煙霧剤等に製剤して使用するのがよい。 In the composition of the present invention, the nitrophenol compound and the bactericidal active compound may be simply added without adding other components, but usually, a solid carrier, a liquid carrier and a gaseous carrier (propellant) are mixed and necessary. Add surfactants and other pharmaceutical auxiliaries according to the formulation and formulate into oil, emulsion, wettable, flowable, granules, powder, aerosol, aerosol etc according to the usual formulation method Good to use.
　これらの製剤には、有効成分であるニトロフェノール化合物及び殺菌活性化合物の合計量を、通常、重量比で０．０１～９５重量％、好ましくは０．１～５０重量％含有させるのがよい。 In these preparations, the total amount of the nitrophenol compound as an active ingredient and the bactericidal active compound is usually contained in an amount of 0.01 to 95% by weight, preferably 0.1 to 50% by weight.
　製剤化の際に用いられる固体担体としては、例えば、粘土類（カオリンクレー、珪藻土、合成含水酸化珪素、ベントナイト、フバサミクレー、酸性白土等）、タルク類、セラミック、その他の無機鉱物（セライト、石英、硫黄、活性炭、炭酸カルシウム、水和シリカ等）、化学肥料（硫安、燐安、硝安、尿素、塩安等）等の微粉末あるいは粒状物等が挙げられる。 Examples of solid carriers used in formulation include clays (kaolin clay, diatomaceous earth, synthetic hydrous silicon oxide, bentonite, hubashi clay, acid clay etc), talcs, ceramics, other inorganic minerals (celite, quartz, Fine powders or particles of sulfur, activated carbon, calcium carbonate, hydrated silica, etc., chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, sodium chloride etc.) and the like can be mentioned.
　液体担体としては、例えば、水、アルコール類（メタノール、エタノール等）、ケトン類（アセトン、メチルエチルケトン等）、芳香族炭化水素類（ベンゼン、トルエン、キシレン、エチルベンゼン、メチルナフタレン等）、脂肪族炭化水素類（ヘキサン、シクロヘキサン、灯油、軽油等）、エステル類（酢酸エチル、酢酸ブチル等）、ニトリル類（アセトニトリル、イソブチロニトリル等）、エーテル類（ジイソプロピルエーテル、ジオキサン等）、酸アミド類（Ｎ，Ｎ－ジメチルホルムアミド、Ｎ，Ｎ－ジメチルアセトアミド等）、ハロゲン化炭化水素類（ジクロロメタン、トリクロロエタン、四塩化炭素等）、ジメチルスルホキシド、大豆油、綿実油等の植物油等が挙げられる。 Examples of the liquid carrier include water, alcohols (methanol, ethanol etc.), ketones (acetone, methyl ethyl ketone etc.), aromatic hydrocarbons (benzene, toluene, xylene, ethylbenzene, methyl naphthalene etc.), aliphatic hydrocarbons (Hexane, cyclohexane, kerosene, light oil etc.), esters (ethyl acetate, butyl acetate etc.), nitriles (acetonitrile, isobutyronitrile etc.), ethers (diisopropyl ether, dioxane etc.), acid amides (N , N-dimethylformamide, N, N-dimethylacetamide and the like), halogenated hydrocarbons (dichloromethane, trichloroethane, carbon tetrachloride and the like), vegetable oils such as dimethylsulfoxide, soybean oil, cottonseed oil and the like.
　ガス状担体としては、例えば、ブタンガス、ＬＰＧ（液化石油ガス）、ジメチルエーテル、炭酸ガス等が挙げられる。 Examples of the gaseous carrier include butane gas, LPG (liquefied petroleum gas), dimethyl ether, carbon dioxide gas and the like.
　界面活性剤としては、例えば、アルキル硫酸エステル類、アルキルスルホン酸塩、アルキルアリールスルホン酸塩、アルキルアリールエーテル類及びそのポリオキシエチレン化物、ポリエチレングリコールエーテル類、多価アルコールエステル類、糖アルコール誘導体等が挙げられる。 As the surfactant, for example, alkyl sulfates, alkyl sulfonates, alkyl aryl sulfonates, alkyl aryl ethers and their polyoxyethylene derivatives, polyethylene glycol ethers, polyhydric alcohol esters, sugar alcohol derivatives, etc. Can be mentioned.
　製剤用補助剤としては、例えば、固着剤、分散剤、安定剤等が挙げられる。 As a formulation adjuvant, a sticking agent, a dispersing agent, a stabilizer etc. are mentioned, for example.
　固着剤及び／又は分散剤としては、例えば、カゼイン、ゼラチン、多糖類（でんぷん粉、アラビアガム、セルロース誘導体、アルギン酸等）、リグニン誘導体、ベントナイト、糖類、合成水溶性高分子（ポリビニルアルコール、ポリビニルピロリドン、ポリアクリル酸類等）が挙げられる。安定剤としては、例えば、ＰＡＰ（酸性リン酸イソプロピル）、ＢＨＴ（２，６－ジ－ｔｅｒｔ－ブチル－４－メチルフェノール）、ＢＨＡ（２－ｔｅｒｔ－ブチル－４－メトキシフェノールと３－ｔｅｒｔ－ブチル－４－メトキシフェノールの混合物）、植物油、鉱物油、脂肪酸又はそのエステル等が挙げられる。 As the fixing agent and / or the dispersing agent, for example, casein, gelatin, polysaccharide (starch powder, gum arabic, cellulose derivative, alginic acid etc.), lignin derivative, bentonite, saccharide, synthetic water-soluble polymer (polyvinyl alcohol, polyvinyl pyrrolidone) And polyacrylic acids, etc.). As the stabilizer, for example, PAP (isopropyl acid phosphate), BHT (2,6-di-tert-butyl-4-methylphenol), BHA (2-tert-butyl-4-methoxyphenol and 3-tert- (Butyl 4-methoxyphenol mixture), vegetable oil, mineral oil, fatty acid or ester thereof and the like.
　本発明の殺菌剤は、そのままで、或いは水等で希釈して用いるのがよい。また他の殺虫剤、殺線虫剤、殺ダニ剤、殺菌剤、除草剤、植物成長調節剤、共力剤、土壌改良剤、動物用飼料等と混合して、又は混合せずに同時に用いることもできる。 The disinfectant of the present invention may be used as it is or diluted with water or the like. It is also used simultaneously with or without mixing with other insecticides, nematocides, acaricides, fungicides, herbicides, plant growth regulators, synergists, soil conditioners, animal feed etc. It can also be done.
　本発明組成物を農業用殺菌剤として用いる場合、その施用量は、通常１０００ｍ２当たり０．１ｇ～５００ｇ、好ましくは１～１００ｇである。乳剤、水和剤、フロアブル剤等の形態の本発明相乗的殺菌剤組成物を水で希釈して用いる場合は、その施用濃度は通常１～１０００ｐｐｍ、好ましくは１０～５００ｐｐｍであり、粒剤、粉剤等は何ら希釈することなく製剤のままで施用される。より具体的には、ニトロフェノール化合物の施用濃度は通常０．５～８００ｐｐｍ程度、好ましくは１２．５～４００ｐｐｍ程度、より好ましくは１００～２００ｐｐｍ程度、殺菌活性化合物の施用濃度は通常０．１～２００ｐｐｍ程度、好ましくは０．１～５０ｐｐｍ程度、より好ましくは０．４～２０ｐｐｍ程度がよい。 When the composition of the present invention is used as an agricultural bactericide, its application amount is usually 0.1 g to 500 g, preferably 1 to 100 g, per 1000 m 2 . When the present synergistic germicidal composition of the present invention in the form of emulsion, wettable powder, flowable and the like is used after dilution with water, its application concentration is usually 1 to 1000 ppm, preferably 10 to 500 ppm. Powders and the like are applied as they are, without dilution. More specifically, the application concentration of the nitrophenol compound is usually about 0.5 to 800 ppm, preferably about 12.5 to 400 ppm, more preferably about 100 to 200 ppm, and the application concentration of the bactericidal compound is usually 0.1 to It is about 200 ppm, preferably about 0.1 to 50 ppm, and more preferably about 0.4 to 20 ppm.
　これらの施用量、施用濃度は、いずれも製剤の種類、施用時期、施用場所、施用方法、害虫の種類、被害程度等の状況によって異なり、上記の範囲に限定されることなく増加させたり、減少させたりすることができる。 The application rate and application concentration of these all depend on the type of preparation, application time, place of application, application method, type of pest, degree of damage, etc., and increase or decrease without being limited to the above range It can be done.
　本発明の相乗的殺菌剤組成物にニトロフェノール化合物と殺菌活性化合物とを含有させ、それを使用することを説明したが、ニトロフェノール化合物と殺菌活性化合物とを別個に含有する組成物を調製しておき、農園芸病原菌の防除の際にこれら２種の組成物を順次又は同時に、好ましくは同時に使用してもよい。この場合、ニトロフェノール化合物及び殺菌活性化合物は、上記と同様の割合で併用するのがよい。 In the synergistic bactericidal composition of the present invention, the nitrophenol compound and the bactericidal active compound are contained to explain the use thereof, but a composition separately containing the nitrophenol compound and the bactericidal active compound is prepared. Alternatively, these two compositions may be used sequentially or simultaneously, preferably simultaneously, in controlling agricultural and horticultural pathogens. In this case, the nitrophenol compound and the bactericidal compound may be used in combination in the same proportion as described above.
　本発明の相乗的殺菌剤組成物は、施用形態により、真菌類、真正細菌類、及び植物ウイルス類に起因する植物の病害を防除することができる。 The synergistic fungicidal composition of the present invention can control plant diseases caused by fungi, eubacteria and plant viruses depending on the application form.
　本発明の相乗的殺菌剤組成物が防除することのできる真正細菌類としては、例えば、以下の属に属する病原菌が挙げられる。 The eubacteria that the synergistic microbicidal composition of the present invention can control include, for example, pathogens belonging to the following genera.
　Burkholderia属菌、例えば、
イネもみ枯細菌病（Burkholderia gladioli）、
イネ苗立枯細菌病（Burkholderia plantarii）；
　Erwinia属菌、例えば、
ダイコン軟腐病（Erwinia carotovora spp. carotovora）；
　Pseudomonas属菌、例えば、
キュウリ斑点細菌病（Pseudomonas syringae pv. lachrymans）、
ダイコン黒斑細菌病（Pseudomonas syringae pv. maculicola）、
ハクサイ黒斑細菌病（Pseudomonas cannabina pv. alisalensis）、
レタス腐敗病（Pseudomonas cichorii）、
キク斑点細菌病（Pseudomonas cichorii）；
　Xanthomonas属菌、例えば、
キャベツ黒腐病（Xanthomonas campestris pv. campestris）、
イネ白葉枯病菌（Xanthomonas oryzae pv. oryzae）、
カンキツかいよう病（Xanthomonas citri supsp. citri）；
　Ralstonia属菌、例えば、
ナス科野菜青枯病（Ralstonia solanacearum）；
　Acidovorax属菌、例えば、
スイカ果実汚斑細菌病（Acidovorax avenae spp. citrulli）、
イネ褐条病（Acidovorax avenae spp. avenae）；
　Brenneria属菌、例えば、
モモせん孔細菌病（Brenneria nigrifluens）;
　Clavibacter属菌、例えば、
トマトかいよう病（Clavibacter michiganensis spp. michiganensis）;
　Streptomyces属菌、例えば、
じゃがいもそうか病（Streptomyces scabies）
等が挙げられる。 For example, Burkholderia spp.
Rice blight (Burkholderia gladioli),
Rice seedling bacterial blight (Burkholderia plantarii);
For example, Erwinia spp.
Japanese radish soft rot (Erwinia carotovora spp. Carotovora);
Pseudomonas, for example,
Cucumber spot bacterial blight (Pseudomonas syringae pv. Lachrymans),
Radish black spot blight (Pseudomonas syringae pv. Maculicola),
Chinese cabbage black spot blight (Pseudomonas cannabina pv. Alisalensis),
Lettuce rot (Pseudomonas cichorii),
Chrysanthemum blight disease (Pseudomonas cichorii);
Xanthomonas, for example,
Cabbage black rot (Xanthomonas campestris pv. Campestris),
Xanthomonas oryzae (Xanthomonas oryzae pv. Oryzae),
Citrus canker (Xanthomonas citri supsp. Citri);
Ralstonia, for example,
Solanaceous vegetable blight (Ralstonia solanacearum);
Acidovorax, for example,
Watermelon fruit stain bacterial disease (Acidovorax avenae spp. Citrulli),
Rice brown stripe disease (Acidovorax avenae spp. Avenae);
For example, Brenneria sp.
Peach canker bacterial disease (Brenneria nigrifluens);
Clavibacter, for example,
Tomato scab (Clavibacter michiganensis spp. Michiganensis);
Streptomyces, for example,
Potato scum disease (Streptomyces scabies)
Etc.
　本発明の相乗的殺菌剤組成物が防除することのできる真菌類としては、例えば、以下の属に属する病原菌が挙げられる。 Fungi that can be controlled by the synergistic fungicidal composition of the present invention include, for example, pathogens belonging to the following genus.
　Alternaria属菌、例えば、
キャベツ黒斑病（Alternaria brassicae）、
キャベツ黒すす病（Alternaria brassicicola）、
ジャガイモ夏疫病（Alternari solani）、
ハクサイ黒斑病（Alternaria brassicae、Alternaria brassicicola）、
カボチャ黒斑病（Alternaria cucumerina）、
ナス褐斑病（Alternaria solani）、
キュウリ黒斑病（Alternaria cucumerina）、
リンゴ斑点落葉病（Alternaria alternata）、
ニンジン黒葉枯病（Alternaria dauci）、
ニンジン黒斑病（Alternaria radicina）、
イチゴ黒斑病（Alternaria alternata）、
タマネギにせ黒斑病（Alternaria porri）、
ナシ黒斑病（Alternaria kikuchiana）、
タマネギ黒斑病（Alternaria sp.）、
ネギ黒斑病（Alternaria porri）;
　Aureobasidium属菌、例えば、
カキすす病（Aureobasidium pullulans）;
　Botrytis属菌、例えば、
イチゴ灰色かび病（Botrytis cinerea）、
タマネギ小菌核性腐敗病（Botrytis squamosa）、
タマネギ灰色腐敗病（Botrytis allii）、
ニラ白斑葉枯病（Botrytis byssoidea）、
ネギ小菌核腐敗病（Botrytis squamosa）；
　Colletotrichum属菌、例えば、
コムギ炭疽病（Colletotrichum graminicola）、
ジャガイモ炭疽病（Colletotrichum atramentarium ）、
コマツナ炭疽病（Colletotrichum higginsianum）、
アズキ炭疽病（Colletotrichum phaseolorum）、
チャ炭疽病（Colletotrichum theae-sinensis）、
インゲンマメ炭疽病（Colletotrichum lindemuthiamum）、
ダイズ炭疽病（Colletotrichum truncatum）、
ホウレンソウ炭疽病（Colletotrichum spinaciae）、
キュウリ炭疽病（Colletotrichum lagenarium）、
スイカ炭疽病（Colletotrichum orbiculare）、
トウガラシ・ピーマン炭疽病（Colletotrichum gloeosporioides）、
イチゴ炭疽病（Colletotrichum acutatum）、
アスパラガス炭疽病（Colletotrichum gloeosporioides）、
セイヨウナシ炭疽病（Colletotrichum gloeosporioides）、
マンゴー炭疽病（Colletotrichum gloeosporioides）、
カキ汚染果病（Colletotrichum ssp.）、
タマネギ炭疽病（Colletotrichum circinans）、
カンキツ炭疽病（Colletotrichum gloeosporioides）、
カンキツさび果病（Colletotrichum gloeosporioides）、
ナシ葉炭疽病（Colletotrichum gloeosporioides）、
ネギ炭疽病（Colletotrichum circinans）；
　Capnodium属菌、例えば、
クリすす病（Capnodium salicinum）、
カンキツすす病（Capnodium salicinum）；
　Capnophaeum属菌、例えば、
カキすす病（Capnophaeum fuliginoides）；
　Cercospora属菌、例えば、
アズキ褐斑病（Cercospora canescens）、
インゲンマメ褐斑病（Cercospora canescens）、
ダイズ紫斑病（Cercospora kikuchii）、
ホウレンソウ褐斑病（Cercospora beticola）、
アスパラガス褐斑病（Cercospora asparagi）、
カキ角斑病（Cercospora kakivora）、
カキ角斑落葉病（Cercospora kaki）；
　Cladosporium属菌、例えば、
タマネギ黄斑病（Cladosporium alliicepae）、
ウメ黒星病（Cladosporium carpophilum）、
カキすす病（Cladosporium herbarum）、
モモ黒星病（Cladosporium carpophilum）；
　Cochliobolus属菌、例えば、
イネごま葉枯病（Cochliobolus miyabeanus）；
　Corynespora属菌、例えば、
キュウリ褐斑病（Corynespora cassiicola）、
メロン褐斑病（Corynespora cassiicola）；
　Cristulariella属菌、例えば、
リンゴ環紋葉枯病（Cristulariella moricola）；
　Diplocarpon属菌、例えば、
リンゴ褐斑病（Diplocarpon mali）、
バラ黒星病（Diplocarpon rosae）；
　Diaporthe属菌、例えば、
カンキツ黒点病（Diaporthe citri）；
　Elsinoe属菌、例えば、
ブドウ黒とう病（Elsinoe ampelina）、
カンキツそうか病（Elsinoe fawcettii）；
　Erysiphe属菌、例えば、
オオムギうどんこ病（Erysiphe graminis f. sp. tritici）、
コムギうどんこ病（Erysiphe graminis f. sp. hordei）、
アズキうどんこ病（Erisiphe pisi）、
ニンジンうどんこ病（Erysiphe heraclei）；
　Fusarium属菌、例えば、
ニンジン萎凋病（Fusarium oxysporum）、
トマト萎凋病（Fusarium oxysporum f. sp. lycopersici）、
イチゴ萎黄病（Fusarium oxysporum）、
タマネギ乾腐病（Fusarium oxysporum f. sp. cerae）、
ウメ心腐病（Fusarium lateritium）、
モモ赤かび病（Fusarium oxysporum）、
キュウリつる割病（Fusarium oxysporum f. sp. cucumerinum）、
メロンつる割病（Fusarium oxysporum f. sp. melonis）；
　Fulvia属菌、例えば、
トマト葉かび病（Fulvia fulva）；
　Fusicladium属菌、例えば、
カキ黒星病（Fusicladium levieri）；
　Gaeumannomyces属菌、例えば、
イネ立枯病（Gaeumannomyces graminis var. graminis）、
オオムギ立枯病（Gaeumannomyces graminis var. tritici）；
　Gibberella属菌、例えば、
イネ馬鹿苗病（Gibberella fujikuroi）、
モモ赤かび病（Gibberella zeae）；
　Glomerella属菌、例えば、
ウメ炭疽病（Glomerella cingulata）、
ウメ葉炭疽病（Glomerella mume）、
オウトウ炭疽病（Glomerella cingulata）、
ブドウ晩腐病（Glomerella cingulata）、
リンゴ炭疽病（Glomerella cingulata）、
カキ汚染果病（Glomerella sp.）、
ナシ炭疽病（Glomerella cingulata）、
カキ葉炭疽病（Glomerella cingulata）、
イチゴ炭疽病（Glomerella cingulata）、
クリ炭疽病（Glomerella cingulata）；
　Gloesporium属菌、例えば、
カキ炭疽病（Gloeosporium kaki）、
モモ炭疽病（Gloeosporium laeticolor）、
シュンギク炭疽病（Gloeosporium chrysanthemi、Gloeosporium carthami）、
コンニャク炭疽病（Gloeosporium conjac）；
　Gymnosporangium属菌、例えば、
ナシ赤星病（Gymnosporangium asiaticum）、
リンゴ赤星病（Gymnosporangium yamadae）；
　Leucotelium属菌、例えば、
ウメ白さび病（Leucotelium prunipersicae）、
モモ白さび病（Leucotelium prunipersicae）；
　Leptothyrium属菌、例えば、
ナシすす点病（Leptothyrium pomi）；
　Microsphaera属菌、例えば、
クリうどんこ病（Microsphaera alphitoides）；
　Monochaetia属菌、例えば、
クリ葉枯病（Monochaetia monochaeta）、
カキすす病（Microxyphium sp.）、
カキ紅葉枯病（Monochaetia dispyri）、
クリ葉枯病（Monochaetia monochaeta）；
　Mycosphaerella属菌、例えば、
カンキツ黄斑病（Mycosphaerella citri、Mycosphaerella horii）、
カンキツそばかす病（Mycosphaerella pinodes）、
ネギ黒渋病（Mycosphaerella allicina）、
カキ円星落葉病（Mycosphaerella nawae）、
イチゴ蛇の目病（Mycosphaerella fragariae）；
　Monilinia属菌、例えば、
ウメ灰星病（Monilinia fructicola、Monilinia laxa）、
オウトウ灰星病（Monilinia fructicola）、
ナシ灰星病（Monilinia fructigena）、
モモ灰星病（Monilinia fructicola）；
　Morenoella属菌、例えば、
クリ褐斑病（Morenoella quercina）；
　Oidiopsis属菌、例えば、
トマトうどんこ病（Oidiopsis sicula）、
トウガラシ・ピーマンうどんこ病（Oidiopsis sicula）；
　Podosphaera属菌、例えば、
オウトウうどんこ病（Podosphaera tridactyla）、
リンゴうどんこ病（Podosphaera leucotricha）、
ウメうどんこ病（Podosphaera tridactyla、
タマネギべと病（Peronospora destructor）、
ネギべと病（Peronospora destructor）；
　Pyriclaria属菌、例えば、
イネいもち病（Pyricularia oryzae）、
ホウレンソウべと病（Peronospora effusa）、
キュウリホモプシス根腐病（Phomopsis sp.）、
モモホモプシス腐敗病（Phomopsis sp.）、
ブドウ黒腐病（Phyllosticta ampelicida）、
ブドウつる割病（Phomopsis viticola）、
ブドウべと病（Plasmopara viticola）、
ナシ輪紋病（Physalospora piricola）、
モモうどんこ病（Podosphaera tridactyla）、
カキ縮葉病（Physalospora kaki）、
カキうどんこ病（Phyllactinia kakikola）、
カキ葉枯病（Pestalotia diospyri）、
モモせん孔病（Phyllosticta persicae）、
コムギ雲形病（Phynchosporium secalis f. sp. hordei）；
　Pleospora属菌、例えば、
タマネギ葉枯病（Pleospora herbarum）、
アカクローバ葉枯病（Pleospora herbarum）、
リンゴ褐色葉枯病（Pleospora herbarum）；
　Phakopsora属菌、例えば、
ダイズさび病（Phakopsora pachyrhizi）；
　Phomopsis属菌、例えば、
アスパラガス茎枯病（Phomopsis asparagi）、
カキ黒点病（Phomopsis kakivora）；
　Phyllactinia属菌、例えば、
セイヨウナシうどんこ病（Phyllactinia mali）、
ナシうどんこ病（Phyllactinia pyri）；
　Phyllosticta属菌、例えば、
アズキ褐紋病（Phyllosticta phaseolina）、
イチゴ輪紋病（Phyllosticta fragariicola）、
ウメ円星病（Pyllosticta mume）；
　Phytophthora属菌、例えば、
スイカ疫病（Phytophthora cryptogea）、
トウガラシ、ピーマン疫病（Phytophthora capsici）、
トマト疫病（Phytophthora infestans）、
ジャガイモ疫病（Phytophthora infestans）、
ナス疫病（Phytophthora infestans）、
ナス褐色腐敗病（Phytophthora capsici）、
イチゴ疫病（Phytophthora nicotianae var. parasitica）、
タマネギ白色疫病（Phytophthora parri）、
タマネギ疫病（Phytophthora nicotianae）、
ネギ疫病（Phytophthora nicotianae）、
キュウリ疫病（Phytophthora melonis）、
セイヨウナシ疫病（Phytophthora cactorum、phytophthora syringae）、
ナシ疫病（Phytophthoracactorum、Phytophthora syringae）、
カンキツ褐色腐敗病（Phytophthora citrophthora）、
リンゴ疫病（Phytophthora cactorum、Phytophthora cambivola、Phytophthora syringae）、
ネギ白色疫病（Phythoththora parri）；
　Pseudocercosporella属菌、例えば、
コムギ眼紋病（Pseudocercosporella herpotrichoides）、
ダイコン白斑病（Pseudocercosporella capsellae）；
　Pseudocercospora属菌、例えば、
カキ黒斑病（Pseudocercospora fuliginosa）、
ウメせん孔病（Pseudocercospora circumscissa）、
ブドウ褐斑病（Pseudocercospora vitis）、
モモせん孔病（Pseudocercospora circumscissa）；
　Pseudoperonospora属菌、例えば、
スイカべと病（Pseudoperonospora cubensis）、
キュウリべと病（Pseudoperonospora cubensis）、
カボチャべと病（Pseudoperonospora cubensis）、
メロンべと病（Pseudoperonospora cubensis）；
　Pyricularia属菌、例えば、
イネいもち病（Pyricularia oryzae）、
オオムギいもち病（Pyricularia grisea）；
　Puccinia属菌、例えば、
タマネギさび病（Puccinia allii）、
タマネギ小菌核病（Puccinia allii）、
ニラさび病（Puccinia allii）、
ネネギさび病（Puccinia allii）、
アスパラガスさび病（Puccinia asparagi-lucidi）、
コムギ黒さび病（Puccinia graminis）、
シュンギクさび病（Puccinia cnicioleracei）；
　Pythium属菌、例えば、
イチゴ果実腐敗病（Pythium ultimum var. ultimum）、
キュウリ苗立枯病（Phythium cucurbitacearum）；
　Rhizopus属菌、例えば、
オウトウ黒かび病（Rhizopus nigricans）、
モモ黒かび病（Rhizopus nigricans）、
キュウリ苗立枯病（Rhyzoctonia solani）；
　Rhizoctonia属菌、例えば、
イネ紋枯病（Rhizoctonia solani）；
　Rosellinia属菌、例えば、
ウメ白紋羽病（Rosellinia necatrix）；
　Scorias属菌、例えば、
カキすす病（Scorias communis）、
ヤマモモすす病（Scorias cylindrica）；
　Sphaceloma属菌、例えば、
ウメそうか病（Sphaceloma pruni-domesticae）、
ザクロそうか病（Sphaceloma punicae）、
ラッカセイそうか病（Sphaceloma arachidis）；
　Sphaerotheca属菌、例えば、
ウメうどんこ病（Sphaerotheca pannosa）、
スイカうどんこ病（Sphaerotheca fuliginea）；
　Stenella属菌、例えば、
モモすすかび病（Stenella sp.）；
　Sptoria属菌、例えば、
タマネギ黒点葉枯病（Septoria alliacea）、
イチゴ白星病（Septoria fragariae）、
サツマイモ白星病（Septoria bataticola）、
コムギ葉枯病（Septoria tritici）、
コンニャク褐斑病（Septoria perillae）；
　Sclerotinia属菌、例えば、
キュウリ菌核病（Sclerotinia sclerotiorum）、
インゲンマメ菌核病（Sclerotinia sclerotiorum）、
ニンジン菌核病（Sclerotinia intermedia、Sclerotinia sclerotiorum）、
イチゴ菌核病（Sclerotinia sclerotiorum）、
ネギ小菌核病（Sclerotinia allii）、
ウメ菌核病（Sclerotinia sclerotiorum）、
オウトウ菌核病（Sclerotinia sclerotiorum）、
ブドウ枝枯菌核病（Sclerotinia sclerotiorum）、
トマト菌核病（Sclerotinia sclerotiorum）、
シュンギク菌核病（Sclerotinia sclerotiorum）、
タマネギ菌核病（Sclerotinia sclerotiorum）、
ナス菌核病（Sclerotinia sclerotiorum）、
スイカ菌核病（Sclerotinia sclerotiorum）、
メロン菌核病（Sclerotinia sclerotiorum）、
トウガラシ・ピーマン菌核病（Sclerotinia sclerotiorum）、
モモ菌核病（Sclerotinia sclerotiorum）、
ハクサイ菌核病（Sclerotinia sclerotiorum）、
キャベツ菌核病（Sclerotinia sclerotiorum）、
アズキ菌核病（Sclerotinia sclerotiorum）；
　Stenella属菌、例えば、
セイヨウナシすすかび病（Stenella sp.）、
モモすすかび病（Stenella sp.）；
　Sphaerotheca属菌、例えば、
キュウリうどんこ病（Sphaerotheca fuliginea）、
イチゴうどんこ病（Sphaerotheca humuli）、
モモうどんこ病（Sphaerotheca pannosa）、
スイカうどんこ病（Sphaerotheca fuliginea）；
　Thanatephorus属菌、例えば、
ジャガイモ黒あざ病（Thanatephorus cucumeris）、
ナス褐色斑点病（Thanatephorus cucumeris）；
　Tripospermum属菌、例えば、
カキすす病（Tripospermum juglandis）；
　Uncinula属菌、例えば、
ブドウうどんこ病（Uncinula necator）；
　Verticillium属菌、例えば、
イチゴ萎凋病（Verticillium dahliae）；
　Venturia属菌、例えば、
セイヨウナシ黒星病（Venturia pirina）、
ナシ黒星病（Venturia nashicola）、
リンゴ黒星病（Venturia inaequalis）；
　Zygophiala属菌、例えば、
リンゴすす点病（Zygophiala jamaicensis）、
カキすす点病（Zygophiala jamaicensis）
等が挙げられる。 Alternaria spp., For example,
Black spot disease of cabbage (Alternaria brassicae),
Cabbage scab (Alternaria brassicicola),
Potato scab (Alternari solani),
Chinese cabbage black spot (Alternaria brassicae, Alternaria brassicicola),
Pumpkin black spot (Alternaria cucumerina),
Eggplant brown spot (Alternaria solani),
Cucumber black spot (Alternaria cucumerina),
Apple spotted leaf blight (Alternaria alternata),
Carrot black leaf blight (Alternaria dauci),
Carrot black spot (Alternaria radicina),
Strawberry black spot (Alternaria alternata),
Black spot (Alternaria porri) onion,
Pear black spot (Alternaria kikuchiana),
Onion black spot (Alternaria sp.),
Spring onion (Alternaria porri);
For example, Aureobasidium spp.
Persimmon soot disease (Aureobasidium pullulans);
Botrytis, for example,
Strawberry gray mold (Botrytis cinerea),
Onion germicidal rot (Botrytis squamosa),
Onion gray rot (Botrytis allii),
Chinese cabbage leaf blight (Botrytis byssoidea),
Green onions (Botrytis squamosa);
Colletotrichum spp., For example,
Wheat anthracnose (Colletotrichum graminicola),
Potato anthracnose (Colletotrichum atramentarium),
Komatsuna anthrax (Colletotrichum higginsianum),
Azuki Anthracnose (Colletotrichum phaseolorum),
Tea anthracnose (Colletotrichum theae-sinensis),
Bean bean anthracnose (Colletotrichum lindemuthiamum),
Soybean anthracnose (Colletotrichum truncatum),
Spinach anthracnose (Colletotrichum spinaciae),
Cucumber anthracnose (Colletotrichum lagenarium),
Watermelon anthracnose (Colletotrichum orbiculare),
Pepper and pepper anthracnose (Colletotrichum gloeosporioides),
Strawberry anthracnose (Colletotrichum acutatum),
Asparagus anthracnose (Colletotrichum gloeosporioides),
Pear anthracnose (Colletotrichum gloeosporioides),
Mango anthrax (Colletotrichum gloeosporioides),
Persimmon Contamination Fruit Disease (Colletotrichum ssp.),
Onion anthracnose (Colletotrichum circinans),
Citrus anthracnose (Colletotrichum gloeosporioides),
Citrus rust (Colletotrichum gloeosporioides),
Pear leaf anthracnose (Colletotrichum gloeosporioides),
Spring onion (Colletotrichum circinans);
Capnodium spp., For example,
Chestnut sickle (Capnodium salicinum),
Citrus soot (Capnodium salicinum);
Capnophaeum genus bacteria, for example,
Persimmon soot disease (Capnophaeum fuliginoides);
Cercospora, for example,
Azuki bean brown spot (Cercospora canescens),
Bean brown spot disease (Cercospora canescens),
Soybean purpura (Cercospora kikuchii),
Spinach brown spot (Cercospora beticola),
Asparagus brown spot (Cercospora asparagi),
Persimmon leaf blight (Cercospora kakivora),
Persimmon leaf blotch (Cercospora kaki);
Cladosporium, for example,
Onion yellow spot (Cladosporium alliicepae),
Japanese plum scab (Cladosporium carpophilum),
Persimmon soot disease (Cladosporium herbarum),
Peach scab (Cladosporium carpophilum);
Cochliobolus, for example,
Rice sesame leaf blight (Cochliobolus miyabeanus);
Corynespora, for example,
Cucumber brown spot (Corynespora cassiicola),
Melon brown spot (Corynespora cassiicola);
For example, Cristulariella spp.
Apple ring leaf blight (Cristulariella moricola);
Diplocarpon, for example,
Apple brown spot (Diplocarpon mali),
Rose scab (Diplocarpon rosae);
For example, Diaporthe spp.
Citrus sunspot (Diaporthe citri);
For example, Elsinoe spp.
Grapevine rot (Elsinoe ampelina),
Citrus scab (Elsinoe fawcettii);
Erysiphe, for example,
Barley powdery mildew (Erysiphe graminis f. Sp. Tritici),
Wheat powdery mildew (Erysiphe graminis f. Sp. Hordei),
Azuki bean powdery mildew (Erisiphe pisi),
Carrot powdery mildew (Erysiphe heraclei);
For example, Fusarium spp.
Carrot wilt (Fusarium oxysporum),
Tomato wilt (Fusarium oxysporum f. Sp. Lycopersici),
Strawberry yellow rot (Fusarium oxysporum),
Dry rot of onion (Fusarium oxysporum f. Sp. Cerae),
Japanese plum rot (Fusarium lateririum),
Peach scab (Fusarium oxysporum),
Cucumber scald (Fusarium oxysporum f. Sp. Cucumerinum),
Melon vines (Fusarium oxysporum f. Sp. Melonis);
Fulvia, for example,
Tomato leaf mold (Fulvia fulva);
Fusicladium genus bacteria, for example,
Persimmon scab (Fusicladium levieri);
Gaeumannomyces genus bacteria, for example,
Rice blight (Gaeumannomyces graminis var. Graminis),
Barley dwarf (Gaeumannomyces graminis var. Tritici);
Gibberella genus bacteria, for example,
Rice fool seedling disease (Gibberella fujikuroi),
Peach scab (Gibberella zeae);
Glomerella genus bacteria, for example,
Plum anthracnose (Glomerella cingulata),
Ume leaf anthracnose (Glomerella mume),
Sweet cherry anthrax (Glomerella cingulata),
Grape late rot (Glomerella cingulata),
Apple anthrax (Glomerella cingulata),
Persimmon fruit disease (Glomerella sp.),
Pear anthracnose (Glomerella cingulata),
Persimmon leaf anthracnose (Glomerella cingulata),
Strawberry anthrax (Glomerella cingulata),
Chestnut anthrax (Glomerella cingulata);
Gloesporium genus bacteria, for example,
Oyster anthrax (Gloeosporium kaki),
Peach anthrax (Gloeosporium laeticolor),
Sundew anthrax (Gloeosporium chrysanthemi, Gloeosporium carthami),
Konnjak anthrax (Gloeosporium conjac);
Gymnosporangium, for example,
Pear red star disease (Gymnosporangium asiaticum),
Apple red star disease (Gymnosporangium yamadae);
Leucotelium, for example,
Ume white rust (Leucotelium prunipersicae),
Peach white rust (Leucotelium prunipersicae);
Leptothyrium, for example,
Pear soot disease (Leptothyrium pomi);
Microsphaera, for example,
Chestnut powdery mildew (Microsphaera alphitoides);
Monochaetia spp., For example,
Chestnut leaf blight (Monochaetia monochaeta),
Oyster soot disease (Microxyphium sp.),
Persimmon foliage blight (Monochaetia dispyri),
Chestnut leaf blight (Monochaetia monochaeta);
Mycosphaerella, for example,
Citrus yellow spot (Mycosphaerella citri, Mycosphaerella horii),
Citrus soak (Mycosphaerella pinodes),
Green onion disease (Mycosphaerella allicina),
Oyster circle Star disease (Mycosphaerella nawae),
Strawberry snake eye disease (Mycosphaerella fragariae);
Monilinia genus bacteria, for example,
Japanese measles (Monilinia fructicola, Monilinia laxa),
Sweet cherry (Monilinia fructicola),
Pear husk disease (Monilinia fructigena),
Peach husk disease (Monilinia fructicola);
Morenoella spp., For example,
Chestnut brown spot (Morenoella quercina);
Oidiopsis genus bacteria, for example,
Tomato powdery mildew (Oidiopsis sicula),
Hot pepper, green pepper powdery mildew (Oidiopsis sicula);
Podosphaera genus bacteria, for example,
Sweet potato powdery mildew (Podosphaera tridactyla),
Apple powdery mildew (Podosphaera leucotricha),
Ume powdery mildew (Podosphaera tridactyla,
Onion downy mildew (Peronospora destructor),
Negoti disease (Peronospora destructor);
Pyriclaria spp., For example,
Rice blast (Pyricularia oryzae),
Spinach downy mildew (Peronospora effusa),
Cucumber homoposis root rot (Phomopsis sp.),
Peachopsis rot (Phomopsis sp.),
Grape black rot (Phyllosticta ampelicida),
Grape scab (Phomopsis viticola),
Grape downy mildew (Plasmopara viticola),
Pear Rash (Physalospora piricola),
Peach powdery mildew (Podosphaera tridactyla),
Persimmon leaf blight (Physalospora kaki),
Oyster powdery mildew (Phyllactinia kakikola),
Persimmon leaf blight (Pestalotia diospyri),
Peach canker (Phyllosticta persicae),
Wheat cloud disease (Phynchosporium secalis f. Sp. Hordei);
Pleospora, for example,
Onion leaf blight (Pleospora herbarum),
Red clover leaf blight (Pleospora herbarum),
Apple brown leaf blight (Pleospora herbarum);
Phakopsora genus bacteria, for example,
Soybean rust (Phakopsora pachyrhizi);
Phomopsis spp., For example,
Asparagus stem blight (Phomopsis asparagi),
Persimmon sunspot (Phomopsis kakivora);
Phyllactinia, for example,
Pear powdery mildew (Phyllactinia mali),
Pear powdery mildew (Phyllactinia pyri);
Phyllosticta, for example,
Azuki bean brown rot (Phyllosticta phaseolina),
Strawberry ring blight (Phyllosticta fragariicola),
Japanese plum blight (Pyllosticta mume);
Phytophthora genus bacteria, for example,
Watermelon epidemic (Phytophthora cryptogea),
Capsicum, peppermint (Phytophthora capsici),
Tomato plague (Phytophthora infestans),
Potato blight (Phytophthora infestans),
Eggplant plague (Phytophthora infestans),
Eggplant brown rot (Phytophthora capsici),
Strawberry plague (Phytophthora nicotianae var. Parasitica),
Onion White blight (Phytophthora parri),
Onion epidemic (Phytophthora nicotianae),
Peg (Phytophthora nicotianae),
Cucumber plague (Phytophthora melonis),
Phytophthora blight (Phytophthora cactorum, phytophthora syringae),
Pear plague (Phytophthoracactorum, Phytophthora syringae),
Citrus brown rot (Phytophthora citrophthora),
Apple plague (Phytophthora cactorum, Phytophthora cambivola, Phytophthora syringae),
Phythoththora parri;
Pseudocercosporella spp., For example,
Wheat eye blight (Pseudocercosporella herpotrichoides),
Japanese white radish (Pseudocercosporella capsellae);
Pseudocercospora, for example,
Persimmon black spot (Pseudocercospora fuliginosa),
Japanese poplar canker (Pseudocercospora circumscissa),
Grapevine blight (Pseudocercospora vitis),
Peach canker (Pseudocercospora circumscissa);
Pseudoperonospora, for example,
Watermelon downy mildew (Pseudoperonospora cubensis),
Cucumber downy mildew (Pseudoperonospora cubensis),
Pumpkin downy mildew (Pseudoperonospora cubensis),
Melon downy mildew (Pseudoperonospora cubensis);
Pyricularia, for example,
Rice blast (Pyricularia oryzae),
Barley rice blast (Pyricularia grisea);
Puccinia, for example,
Onion rust (Puccinia allii),
Onion small scale disease (Puccinia allii),
Leek rust disease (Puccinia allii),
Spring onion (Puccinia allii),
Asparagus rust (Puccinia asparagi-lucidi),
Wheat leaf rust (Puccinia graminis),
Sunchilli rust (Puccinia cnicioleracei);
Pythium, for example,
Strawberry fruit rot (Pythium ultimum var. Ultimum),
Cucumber seedling blight (Phythium cucurbitacearum);
Rhizopus, for example,
Sweet potato scab (Rhizopus nigricans),
Peach black mold (Rhizopus nigricans),
Cucumber seedling blight (Rhyzoctonia solani);
Rhizoctonia spp., For example,
Rice sheath blight (Rhizoctonia solani);
For example, Rosellinia sp.
Ume white scab (Rosellinia necatrix);
For example,
Oyster soot disease (Scorias communis),
Yamamomo soot disease (Scorias cylindrica);
Sphaceloma spp., For example,
Japanese sweet potato scum (Sphaceloma pruni-domesticae),
Pomegranate scum disease (Sphaceloma punicae),
Peanut scab (Sphaceloma arachidis);
Sphaerotheca genus bacteria, for example,
Ume powdery mildew (Sphaerotheca pannosa),
Watermelon powdery mildew (Sphaerotheca fuliginea);
Stenella spp., For example,
Peach scab (Stenella sp.);
Sptoria spp, for example,
Black onion blight (Septoria alliacea),
Strawberry scab (Septoria fragariae),
Sweet potato scab (Septoria bataticola),
Wheat leaf blight (Septoria tritici),
Konjac brown spot (Septoria perillae);
Sclerotinia, for example,
Cucumber mycosis (Sclerotinia sclerotiorum),
Bean scrotosis (Sclerotinia sclerotiorum),
Carrot scab (Sclerotinia intermedia, Sclerotinia sclerotiorum),
Sclerotinia sclerotiorum (Sclerotinia sclerotiorum),
Sclerotinia allii, small green onion disease,
Sclerotinia sclerotiorum,
Sweet potato blight (Sclerotinia sclerotiorum),
Grape leaf blight (Sclerotinia sclerotiorum),
Sclerotinia sclerotiorum,
Sclerotinia sclerotiorum,
Sclerotinia sclerotiorum,
Eggplant blight (Sclerotinia sclerotiorum),
Sclerotinia sclerotiorum (Sclerotinia sclerotiorum),
Sclerotinia sclerotiorum,
Hot pepper · pepper fungus (Sclerotinia sclerotiorum),
Peach scrotum (Sclerotinia sclerotiorum),
Chinese cabbage nucleoli (Sclerotinia sclerotiorum),
Sclerotinia sclerotiorum,
Sclerotinia sclerotiorum (Sclerotinia sclerotiorum);
Stenella spp., For example,
Pear scab (Stenella sp.),
Peach scab (Stenella sp.);
Sphaerotheca genus bacteria, for example,
Cucumber powdery mildew (Sphaerotheca fuliginea),
Strawberry powdery mildew (Sphaerotheca humuli),
Peach powdery mildew (Sphaerotheca pannosa),
Watermelon powdery mildew (Sphaerotheca fuliginea);
Thanatephorus, for example,
Potato bruise (Thanatephorus cucumeris),
Eggplant brown spot disease (Thaneatephorus cucumeris);
Tripospermum, for example,
Oyster soot disease (Tripospermum juglandis);
For example, Uncinula spp.
Grape powdery mildew (Uncinula necator);
For example, Verticillium spp.
Strawberry wilt (Verticillium dahliae);
Venturia, for example,
Pear scab (Venturia pirina),
Pear scab (Venturia nashicola),
Apple scab (Venturia inaequalis);
For example, Zygophiala spp.
Apple soot blight (Zygophiala jamaicensis),
Oyster scum disease (Zygophiala jamaicensis)
Etc.
　本発明の相乗的殺菌剤組成物が防除することのできる植物ウイルスとしては、
特に限定されず、例えば、トバモウイルス属、ポテックスウイルス属、カルラウイルス属、ククモウイルス属、カルモウイルス属等が挙げられる。 As a plant virus which can be controlled by the synergistic bactericidal composition of the present invention,
It is not particularly limited, and examples thereof include Tobamo virus genus, Potex virus genus, Calla virus genus, Cucumovirus type, Calmovirus genus and the like.
　具体的には、
トバモウイルス属ウイルスとしては、例えば、
タバコモザイクウイルス（Tobacco mosaic virus, TMV）、
トマトモザイクウイルス（Tomato mosaic virus , ToMV）、
キュウリ緑斑モザイクウイルス（Kyuri green mottle mosaic virus , KGMMV）、
トウガラシマイルドモットルウイルス（Pepper mild mottle virus , PMMoV）、
スイカ緑斑モザイクウイルス（Cucumber green mottle mosaic virus , CGMMV）等が挙げられる。
　ポテックスウイルス属ウイルスとしては、例えば、
オオバコモザイクウイルス（Plantago asiatica mosaic virus , PlAMV）、
ジャガイモXウイルス（Potato virus X, PVX）等が挙げられる。
　カルラウイルス属ウイルスとしては、例えば、
ジャガイモモザイクウイルス（Potato virus M, PVM）等が挙げられる。
　ククモウイルス属ウイルスとしては、例えば、
キュウリモザイクウイルス（Cucumber mosaic virus , CMV）等が挙げられる。
　カルモウイルス属ウイルスとしては、例えば、
メロンえそ斑点ウイルス（Melon necrotic spot virus, MNSV）等が挙げられる。 In particular,
As a tobamovirus genus virus, for example,
Tobacco mosaic virus (Tobacco mosaic virus, TMV),
Tomato mosaic virus (Tomato mosaic virus, ToMV),
Cucumber green mottle mosaic virus (Kyuri green mottle mosaic virus, KGMMV),
Pepper milled mottle virus (Pepper mild mottle virus, PMMoV),
Watermelon green mottle mosaic virus (Cucumber green mottle mosaic virus, CGMMV) etc. are mentioned.
As potex virus genus virus, for example,
Planago mosaic virus (Plantago asiatica mosaic virus, PlAMV),
Potato X virus (Potato virus X, PVX) etc. are mentioned.
As a virus of the genus Carla virus,
Potato mosaic virus (Potato virus M, PVM) etc. are mentioned.
Examples of Cucumoviruses include:
Cucumber mosaic virus (Cucumber mosaic virus, CMV) etc. are mentioned.
As the carmovirus genus virus, for example,
Melon necrotic spot virus (Melon necrotic spot virus, MNSV) etc. are mentioned.
　本発明の相乗的殺菌剤組成物を使用できる有用植物としては特に限定はなく、例えば、稲、大麦、小麦、ライ麦、オート麦、トウモロコシ等の穀類；大豆、小豆、そら豆、えんどう豆、インゲン豆、落花生等の豆類；
林檎、柑橘類、梨、葡萄、桃、梅、桜桃、胡桃、栗、アーモンド、バナナ、イチゴ等の果樹・果実類；
キャベツ、トマト、ホウレンソウ、ブロッコリー、レタス、タマネギ、ネギ、ピーマン、ナス、ペッパー等の葉・果菜類；
ニンジン、馬鈴薯、サツマイモ、サトイモ、大根、蓮根、カブ、ゴボウ、ニンニク等根菜類；
棉、麻、ビート、ホップ、サトウキビ、テンサイ、オリーブ、ゴム、コーヒー、タバコ、茶等の加工用作物；
カボチャ、キュウリ、マクワウリ、スイカ、メロン等のウリ類；
オーチャードグラス、ソルガム、チモシー、クローバー、アルファルファ等の牧草類；
高麗芝、ベントグラス等の芝類；
ラベンダー、ローズマリー、タイム、パセリ、胡椒、生姜等の香料鑑賞用作物；
キク、バラ、カーネーション、蘭等の花卉類；
イチョウ、サクラ類、アオキ等の庭木；
トドマツ類、エゾマツ類、松類、ヒバ、杉、桧等の林木等が挙げられる。 There are no particular limitations on useful plants for which the synergistic fungicidal composition of the present invention can be used, and examples include grains such as rice, barley, wheat, rye, oats and corn; soybeans, red beans, broad beans, peas and beans Beans such as beans and peanuts;
Fruits and fruits such as apples, citrus fruits, pears, persimmons, peaches, plums, cherry blossoms, walnuts, chestnuts, almonds, bananas, strawberries, etc .;
Leaves, fruits and vegetables such as cabbage, tomato, spinach, broccoli, lettuce, onion, green onion, green pepper, eggplant, pepper and the like;
Carrot, potato, sweet potato, taro, radish, lotus root, turnip, burdock, garlic etc root vegetables;
Processing crops such as cane, hemp, beets, hops, sugar cane, sugar beet, olives, gum, coffee, tobacco, tea, etc .;
Uri species such as pumpkin, cucumber, mackerel, watermelon, melon;
Grasses such as orchardgrass, sorghum, timothy, clover, alfalfa;
Grasses such as Goryeo grass, bent glass;
Lavender, rosemary, thyme, parsley, pepper, ginger, etc .;
Chrysanthemum, roses, carnations, orchids, etc .;
Garden trees such as Ginkgo, cherry blossoms, Aoki
A pine tree, a pine tree, a pine tree, a hiba, a cedar, a forest tree, such as a rose, etc. are mentioned.
　本発明の相乗的殺菌剤組成物は、かかる農園芸病原菌の生息場所に、又は農園芸病原菌が寄生する植物若しくはその近傍に処理することによって、上記植物を保護することができる。 The synergistic bactericidal composition of the present invention can protect the above plants by treating such agricultural / horticultural pathogens in the habitat or a plant parasitic to the agricultural / horticultural pathogens or in the vicinity thereof.
　病害虫の生息場所、又は病害虫が寄生する植物若しくはその近傍とは、駆除すべき病害虫が棲息する植生、特に茎、葉、種子、球根又は種芋（以下、種子、球根又は種芋を単に種子と略記する。）；果実等に施用できる。施用方法としては、例えば、葉面又は茎への散布、又は噴霧、種子処理（例えば、浸種若しくは粒剤の種子粉衣等）、土壌施用（例えば、粒剤の畦間散布若しくは畦間噴霧等）等が挙げられる。 The habitat of the pest or the plant or its vicinity where the pest infests refers to the vegetation, especially stems, leaves, seeds, bulbs or seeds (hereinafter referred to as seeds, bulbs or seeds) simply as seeds, in which the pest to be controlled is infested It can be applied to fruits, etc. Application methods include, for example, spraying on leaves or stems, or spraying, seed treatment (eg, seed soaking of soaked seeds or granules, etc.), soil application (eg, intercostal spraying or interval spraying of granules, etc.) Etc.).
　ニトロフェノール化合物を含有する殺菌活性増強剤
　上記ニトロフェノール化合物は、公知の殺菌剤に加えることによって、殺菌活性を増強させることができる。すなわち、殺菌活性増強のためにニトロフェノール化合物を使用することができる。 Bactericidal Activity Enhancer Containing a Nitrophenol Compound The above-mentioned nitrophenol compound can enhance its bactericidal activity by being added to a known germicide. That is, nitrophenol compounds can be used to enhance bactericidal activity.
　以下に、実施例、比較例、製剤例、及び試験例を掲げて本発明をより一層明らかにするが、本発明はこれらに限定されるものではない。 EXAMPLES The present invention will be further clarified by the following Examples, Comparative Examples, Formulation Examples and Test Examples, but the present invention is not limited thereto.
　次に製剤例を示す。なお、「部」とあるのは「重量部」を意味する。 Next, formulation examples are shown. The term "parts" means "parts by weight".
　参考製剤例１（乳剤）
　本発明組成物の各々１０部をソルベッソ１５０　４５部及びＮ－メチルピロリドン３５部に溶解し、これに乳化剤（商品名：ソルポール３００５Ｘ、東邦化学（株）製）１０部を加え、撹拌混合して各々の１０％乳剤を得た。 Reference preparation example 1 (emulsion)
10 parts of each of the composition of the present invention is dissolved in 45 parts of Solvesso 150 and 35 parts of N-methylpyrrolidone, 10 parts of an emulsifier (trade name: Sorpol 3005X, manufactured by Toho Chemical Co., Ltd.) is added thereto, and mixed by stirring. Each 10% emulsion was obtained.
　参考製剤例２（水和剤）
　本発明組成物の各々２０部を、ラウリル硫酸ナトリウム２部、リグニンスルホン酸ナトリウム４部、合成含水酸化珪素微粉末２０部及びクレー５４部を混合した中に加え、ジュースミキサーで撹拌混合して２０％水和剤を得た。 Reference preparation example 2 (wettable powder)
Twenty parts of each of the composition of the present invention is added to 2 parts of sodium lauryl sulfate, 4 parts of sodium lignin sulfonate, 20 parts of synthetic hydrous silicon oxide fine powder and 54 parts of clay and mixed by stirring with a juice mixer. % Wettable powder was obtained.
　参考製剤例３（粒剤）
　本発明組成物の各々５部にドデシルベンゼンスルホン酸ナトリウム２部、ベントナイト１０部及びクレー８３部を加え十分撹拌混合した。適用量の水を加え、更に撹拌し、造粒機で造粒し、通風乾燥して５％粒剤を得た。 Reference Preparation Example 3 (Particulates)
Two parts of sodium dodecylbenzene sulfonate, 10 parts of bentonite and 83 parts of clay were added to 5 parts of each of the composition of the present invention and thoroughly mixed. The applied amount of water was added, and the mixture was further stirred, granulated with a granulator and blow-dried to obtain 5% granules.
　参考製剤例４（粉剤）
　本発明組成物の各々１部を適当量のアセトンに溶解し、これに合成含水酸化珪素微粉末５部、酸性リン酸イソプロピル（ＰＡＰ）０．３部及びクレー９３．７部を加え、ジュースミキサーで撹拌混合し、アセトンを蒸発除去して１％粉剤を得た。 Reference preparation example 4 (powder)
1 part of each of the composition of the present invention is dissolved in an appropriate amount of acetone, 5 parts of synthetic hydrous silicon oxide fine powder, 0.3 parts of isopropyl acid phosphate (PAP) and 93.7 parts of clay are added thereto, and a juice mixer The mixture was stirred and mixed, and acetone was removed by evaporation to obtain 1% powder.
　参考製剤例５（フロアブル剤）
　本発明組成物の各々２０部、ポリオキシエチレントリスチリルフェニルエーテルリン酸エステルトリエタノールアミン３部及びローダシル（Rhodorsil）４２６Ｒ０．２部を含む水２０部を混合し、ダイノミルを用いて湿式粉砕後、プロピレングリコール８部及びキサンタンガム０．３２部を含む水６０部と混合し、２０％水中懸濁液を得た。 Reference preparation example 5 (flowable agent)
Twenty parts of each of the composition of the present invention, 3 parts of polyoxyethylene tristyryl phenyl ether phosphate ester triethanolamine, and 20 parts of water containing 0.2 parts of Rhodorsil 426R are mixed and wet-milled using a dyno mill, It was mixed with 60 parts of water containing 8 parts of propylene glycol and 0.32 parts of xanthan gum to obtain a 20% suspension in water.
　＜ニトロフェノール化合物＞
　製剤Ａ
　４－ニトロフェノールナトリウム塩（旭化学工業（株）製）０．９部、２－ニトロフェノールナトリウム塩（旭化学工業（株）製）０．６部、５－ニトログアヤコールナトリウム塩（旭化学工業（株）製）０．３部を、水９９８．２部に溶解し、水溶剤を調製した。この水溶剤を以下「製剤Ａ」という。 <Nitrophenol compound>
Formulation A
4-nitrophenol sodium salt (Asahi Chemical Industry Co., Ltd. product 0.9 parts, 2-nitrophenol sodium salt (Asahi Chemical Industry Co., Ltd. product) 0.6 parts, 5-nitro guaiacol sodium salt (Asahi Chemical Industry Co., Ltd.) 0.3 part of Co., Ltd. product was dissolved in 998.2 parts of water to prepare a water solvent. This water solvent is hereinafter referred to as "formulation A".
　製剤Ｂ
　４－ニトロフェノールナトリウム塩（旭化学工業（株）製）０．９部を、水９９９．１部に溶解し、水溶剤を調製した。この水溶剤を以下「製剤Ｂ」という。 Formulation B
0.9 part of 4-nitrophenol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) was dissolved in 999.1 parts of water to prepare a water solvent. This water solvent is hereinafter referred to as "formulation B".
　製剤Ｃ
　２－ニトロフェノールナトリウム塩（旭化学工業（株）製）０．６部を水９９９．４部に溶解し、水溶剤を調製した。この水溶剤を以下「製剤Ｃ」という。 Formulation C
A water solvent was prepared by dissolving 0.6 part of 2-nitrophenol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) in 999.4 parts of water. This water solvent is hereinafter referred to as "Formulation C".
　製剤Ｄ
　５－ニトログアヤコールナトリウム塩（旭化学工業（株）製）０．３部を、水９９９．７部に溶解し、水溶剤を調製した。この水溶剤を以下「製剤Ｄ」という。 Preparation D
0.3 part of 5-nitro guaiacol sodium salt (manufactured by Asahi Chemical Industry Co., Ltd.) was dissolved in 999.7 parts of water to prepare a water solvent. This water solvent is hereinafter referred to as "Formulation D".
　＜殺菌活性化合物＞
　製剤Ｅ
　ピラクロストロビンとボスカリドを含む顆粒水和剤としてBASFアグロ（株）製のナリア（登録商標）WDG（ピラクロストロビン６．８重量％とボスカリド１３．６重量％を含む顆粒水和剤）を用意した。この製剤を「製剤Ｅ」とする。 <Fungicidally active compound>
Preparation E
Naria (registered trademark) WDG (a water dispersible powder containing 6.8% by weight of pyraclostrobin and 13.6% by weight of boscalid) manufactured by BASF Agro Co., Ltd. is prepared as a water dispersible powder containing pyraclostrobin and boscalid. did. This preparation is referred to as "formulation E".
　製剤Ｆ
　フルアジナムを含むフロアブル剤としてBASFアグロ（株）製のフロンサイド（登録商標）SC（フルアジナム３９．５重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｆ」とする。 Formulation F
As a flowable agent containing fluazinam, Freonside (registered trademark) SC (a flowable agent containing 39.5% by weight of fluazinam) manufactured by BASF Agro Co., Ltd. was prepared. This preparation is referred to as "formulation F".
　製剤Ｇ
　ピコキシストロビンを含むフロアブル剤として日本農薬（株）製のメジャー（登録商標）フロアブル（ピコキシストロビン２２．５重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｇ」とする。 Formulation G
As a flowable agent containing picoxystrobin, Major (registered trademark) flowable (a flowable agent containing 22.5% by weight of picoxystrobin) manufactured by Japan Pesticides Co., Ltd. was prepared. This preparation is referred to as "formulation G".
　製剤Ｈ
　シアゾファミドを含むフロアブル剤として石原バイオサイエンス（株）製のランマン（登録商標）フロアブル（シアゾファミド９．４重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｈ」とする。 Formulation H
As a flowable agent containing cyazofamide, Lanman (R) flowable (a flowable agent containing 9.4% by weight of cyanophamide) manufactured by Ishihara Biosciences Co., Ltd. was prepared. This preparation is referred to as "formulation H".
　製剤Ｉ
　ファモキサドンとシモキサニルを含むDF剤として日産化学工業（株）製のホライゾン（登録商標）DF剤（ファモキサドン２２．５重量％とシモキサニル３０重量％を含むDF剤）を用意した。この製剤を「製剤Ｉ」とする。 Formulation I
Horison (registered trademark) DF agent (DF agent containing 22.5% by weight of famoxadone and 30% by weight of shimoxanil) manufactured by Nissan Chemical Industries, Ltd. was prepared as a DF agent containing famoxadone and shimoxanil. This preparation is referred to as "formulation I".
　製剤Ｊ
　トリフロキシストロビンを含むフロアブル剤としてバイエルクロップサイエンス製のフリント（登録商標）フロアブル２５（トリフロキシストロビン２５重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｊ」とする。 Formulation J
As a flowable agent containing trifloxystrobin, Flint.RTM. Flowable 25 (a flowable agent containing 25% by weight of trifloxystrobin) manufactured by Bayer CropScience was prepared. This preparation is referred to as "formulation J".
　製剤Ｋ
　クロロタロニルを含む水和剤として住友化学（株）製のダコニール（登録商標）１０００（クロロタロニル４０重量％を含む水和剤）を用意した。この製剤を「製剤Ｋ」とする。 Formulation K
As a wettable powder containing chlorothalonil, Daconil (registered trademark) 1000 (a wettable powder containing 40% by weight of chlorothalonil) manufactured by Sumitomo Chemical Co., Ltd. was prepared. This preparation is referred to as "formulation K".
　製剤Ｌ
　ベンチアバリカルブとクロロタロニルを含む顆粒水和剤としてクミアイ化学工業（株）製のプロポーズ（登録商標）顆粒水和剤（ベンチアバリカルブ５重量％とクロロタロニル５０重量％を含む顆粒水和剤）を用意した。この製剤を「製剤Ｌ」とする。 Formulation L
Propose (registered trademark) water dispersible granule manufactured by Kumiai Chemical Industries Co., Ltd. as a water dispersible granule containing bench avaliculum and chlorothalonil (a water dispersible granule containing 5% by weight of bench alkaline carb and 50% by weight of chlorothalonil) Prepared. This preparation is referred to as "formulation L".
　製剤Ｍ
　クレソキシムメチルを含むDF剤として日産化学工業（株）製のストロビー（登録商標）DF（クレソキシムメチル５０重量％を含むDF剤）を用意した。この製剤を「製剤Ｍ」とする。 Formulation M
Strobie (registered trademark) DF (DF agent containing 50% by weight of kresoxim methyl) manufactured by Nissan Chemical Industries, Ltd. was prepared as a DF agent containing kresoxim methyl. This preparation is referred to as "formulation M".
　製剤Ｎ
　亜リン酸二水素カリウム５６０重量部を純水４４０部で溶解して合計１０００重量部とした。この製剤を「製剤Ｎ」とする。 Formulation N
560 parts by weight of potassium dihydrogen phosphite was dissolved in 440 parts of pure water to make a total of 1000 parts by weight. This preparation is referred to as "formulation N".
　製剤Ｏ
　エタボキサムを含むフロアブル剤として日本曹達（株）製のエトフィン（登録商標）フロアブル（エタボキサム１２．５重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｏ」とする。 Formulation O
Etofin (registered trademark) flowable (a flowable containing 12.5% by weight of Etabaxam) manufactured by Nippon Soda Co., Ltd. was prepared as a flowable containing Etabaxam. This preparation is referred to as "formulation O".
　製剤Ｐ
　アメトクトラジンとジメトモルフ含むフロアブル剤としてBASFアグロ（株）製のザンプロ（登録商標）DMフロアブル（アメトクトラジン２７重量％とジメトモルフ２０．３重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｐ」とする。 Formulation P
As a flowable agent containing amethocutrazine and dimethomorph, ZANPRO (registered trademark) DM flowable (a flowable agent containing 27% by weight of ametocutrazine and 20.3% by weight of dimethomorph) manufactured by BASF Agro Co., Ltd. was prepared. This preparation is referred to as "formulation P".
　製剤Ｑ
　ジメトモルフと塩基性塩化銅を含む水和剤として北興化学工業（株）製のフェスティバル（登録商標）C水和剤（ジメトモルフ１５重量％、塩基性塩化銅５８．８重量％を含む水和剤）を用意した。この製剤を「製剤Ｑ」とする。 Formulation Q
Festival (trademark) C wettable powder made by Hokuko Chemical Industry Co., Ltd. as a wettable powder containing dimethomorph and basic copper chloride (wettable powder containing 15% by weight dimethomorph, 58.8% by weight basic copper chloride) Prepared. This preparation is referred to as "formulation Q".
　製剤Ｒ
　アゾキシストロビンを含むフロアブル剤としてシンジェンタジャパン（株）製のアミスター（登録商標）２０フロアブル（アゾキシストロビン２０重量％を含むフロアブル剤）を用意した。この製剤を「製剤Ｒ」とする。 Formulation R
As a flowable agent containing azoxystrobin, Amister (registered trademark) 20 flowable (a flowable agent containing 20% by weight of azoxystrobin) manufactured by Syngenta Japan Co., Ltd. was prepared. This preparation is referred to as "formulation R".
　製剤Ｓ
　マンゼブを含む水和剤としてダウ・ケミカル日本（株）製のジマンダイセン（登録商標）水和剤（マンゼブ８０重量％を含む水和剤）を用意した。この製剤を「製剤Ｓ」とする。 Preparation S
As a wettable powder containing manzeb, Dimandaisen (registered trademark) wettable powder (a wettable powder containing 80% by weight of manzeb) manufactured by Dow Chemical Japan Ltd. was prepared. This preparation is referred to as "formulation S".
　製剤Ｔ
　ホセチルアルミニウムを含む水和剤としてバイエルクロップサイエンス（株）製のアリエッティ（登録商標）水和剤（８０重量％を含む水和剤）を用意した。この製剤を「製剤Ｔ」とする。 Formulation T
Arietti (R) wettable powder (a wettable powder containing 80% by weight) manufactured by Bayer CropScience Co., Ltd. was prepared as a wettable powder containing fosetyl aluminum. This preparation is referred to as "formulation T".
　製剤Ｕ
　フルオピコリドとプロパモカルブ塩酸塩を含むフロアブル剤としてバイエルクロップサイエンス（株）製のリライアブル（登録商標）フロアブル（フルオピコリド５．５重量％とプロパモカルブ塩酸塩５５．５％を含むフロアブル剤）を用意した。この製剤を「製剤Ｕ」とする。 Formulation U
As a flowable agent containing fluopicolide and propamocarb hydrochloride, Reliable (registered trademark) flowable (a flowable agent containing 5.5% by weight of fluopicolide and 55.5% of propamocarb hydrochloride) manufactured by Bayer CropScience Co., Ltd. was prepared. This preparation is referred to as "formulation U".
　製剤Ｖ
　ノニルフェノールスルホン酸銅塩を含む液剤としてOATアグリオ（株）製のヨネポン（ノニルフェノールスルホン酸銅塩３０重量％を含む液剤）を用意した。この製剤を「製剤Ｖ」とする。 Formulation V
Yonepon (a solution containing 30% by weight of nonylphenol sulfonic acid copper salt) manufactured by OAT Agrio Co., Ltd. was prepared as a solution containing nonylphenol sulfonic acid copper salt. This preparation is referred to as "formulation V".
　製剤Ｗ
　テトラコナゾールを含む液剤としてアリスタライフサイエンス（株）製のサルバトーレ（登録商標）ME（テトラコナゾール１１．６重量部含む液剤）を用意した。この製剤を「製剤Ｗ」とする。 Formulation W
As a solution containing tetraconazole, Salvatore (registered trademark) ME (a solution containing 11.6 parts by weight of tetraconazole) manufactured by Arista Life Science Co., Ltd. was prepared. This preparation is referred to as "formulation W".
　製剤Ｘ
　フルトリアホール（Sigma社製）５０重量部を９５０重量部のジメチルスルホキシド（東京化成製）で溶解した。この製剤を「製剤Ｘ」とする。 Formulation X
50 parts by weight of flutoriahole (manufactured by Sigma) was dissolved in 950 parts by weight of dimethyl sulfoxide (manufactured by Tokyo Kasei Co., Ltd.). This preparation is referred to as "formulation X".
　製剤Ｙ
　アシベンゾラル－Ｓ－メチル（和光純薬製）１０重量部を９９０重量部のジメチルスルホキシド（東京化成製）で溶解した。この製剤を「製剤Ｙ」とする。 Formulation Y
10 parts by weight of acibenzolar-S-methyl (manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 990 parts by weight of dimethyl sulfoxide (manufactured by Tokyo Kasei Kogyo Co., Ltd.). This preparation is referred to as "formulation Y".
　実施例１
　上記製剤Ｅ（ピラクロストロビン６８０００ppm、ボスカリド１３６０００ppm）と製剤Ａ（ニトロフェノール化合物１８０００ppm）とを混合し、本発明組成物の製剤Ｅ＋Ａを調製した。 Example 1
The above preparation E (pyraclostrobin 68000 ppm, boscalid 136000 ppm) and preparation A (nitrophenol compound 18000 ppm) were mixed to prepare preparation E + A of the composition of the present invention.
　実施例２～３５
　製剤Ｅを、表１～６に記載の製剤Ｆ、製剤Ｇ、製剤Ｈ、製剤Ｉ、製剤Ｊ、製剤Ｋ、製剤Ｌ、製剤Ｍ、製剤Ｎ、製剤Ｏ、製剤Ｐ、製剤Ｑ、製剤Ｒ、製剤Ｓ、製剤Ｔ、製剤Ｕ、製剤Ｖ、製剤Ｗ、製剤Ｘ、及び製剤Ｙにそれぞれ代えた以外は、実施例１と同様の方法で、表１～６に記載の希釈濃度の製剤Ｆ＋Ａ、製剤Ｇ＋Ａ、製剤Ｈ＋Ａ、製剤Ｉ＋Ａ、製剤Ｊ＋Ａ、製剤Ｋ＋Ａ、製剤Ｌ＋Ａ、製剤Ｍ＋Ａ、製剤Ｎ＋Ａ、製剤Ｏ＋Ａ、製剤Ｐ＋Ａ、製剤Ｑ＋Ａ、製剤Ｒ＋Ａ、製剤Ｓ＋Ａ、製剤Ｔ＋Ａ、製剤Ｕ＋Ａ、製剤Ｖ＋Ａ、製剤Ｗ＋Ａ、製剤Ｘ＋Ａ、及び製剤Ｙ＋Ａをそれぞれ調製した。 Examples 2 to 35
Formulation E was formulated as formulation F, formulation G, formulation H, formulation I, formulation J, formulation K, formulation L, formulation M, formulation N, formulation O, formulation P, formulation Q, formulation R, described in Tables 1-6. Formulations F + A at the dilution concentrations described in Tables 1 to 6 in the same manner as Example 1, except that Formulations S, Formulations T, Formulations U, Formulations V, Formulations X, and Formulations Y were replaced, respectively. Formulation G + A, Formulation H + A, Formulation I + A, Formulation J + A, Formulation K + A, Formulation L + A, Formulation M + A, Formulation N + A, Formulation O + A, Formulation P + A, Formulation Q + A, Formulation R + A, Formulation S + A, Formulation T + A, Formulation U + A, Formulation V + A, Formulation W + A , Formulation X + A, and formulation Y + A were prepared respectively.
　試験例１：トマト疫病に対する効力試験
　約１５葉期まで生育させたトマト（品種：大型福寿）の上位３～５葉を先端より５ｃｍ切り取り、試験に使用した。薬剤は切り取り葉を薬液に浸漬処理した。処理後、素寒天培地に葉裏を上にして静置し、風乾させた。トマト疫病菌(Phytophthora infestans)の胞子懸濁液は1×10５の密度となるようにｐＨ７．０のリン酸バッファーで調製した。調製１時間後に胞子懸濁液を切り取り葉に散布処理した。試験区は１試験区あたり３区設置した。管理は昼：１５℃、夜１２℃、照明１２時間の条件下で７日間生育させた。その後、各薬剤の効果を発病面積で評価した。その結果が表１である。 Test Example 1: Efficacy Test Against Tomato Phytophthoma The top 3 to 5 leaves of tomato (variety: large-sized Fukuju) grown to about 15 leaf stages were cut 5 cm from the tip and used for the test. The drug was treated by immersing the cut leaves in a drug solution. After the treatment, it was allowed to stand on a plain agar medium with the back of the leaf up and air-dried. A spore suspension of Phytophthora infestans was prepared with a pH 7.0 phosphate buffer to a density of 1 × 10 5 . One hour after preparation, the spore suspension was sprinkled onto the leaves. Three test zones were established per test zone. The control was grown for 7 days under the conditions of noon: 15 ° C., night 12 ° C., illumination 12 hours. After that, the effect of each drug was evaluated by the affected area. The result is Table 1.
　また、本発明の殺菌剤組成物の期待される有効度（Ｅ）をコルビーの式（Ｗｅｅｄｓ，１５，２０－２２（１９６７））から算出して、計算上の有効度（％）を求めた。 Also, the expected effectiveness (E) of the microbicidal composition of the present invention was calculated from the Colby's equation (Weeds, 15, 20-22 (1967)) to obtain the calculated effectiveness (%) .
　Ｅ＝ｘ＋ｙ－（ｘ・ｙ／１００）
　数式中、Ｅはニトロフェノール化合物及び殺菌活性化合物をそれぞれの濃度ｐ及びｑで使用した場合に期待される有効度を％で示したものである。ｘはニトロフェノール化合物を濃度ｐで使用した時の有効度を示し、ｙは殺菌活性化合物を濃度ｑで使用した時の有効度を示したものである。  E = x + y-(x · y / 100)
In the formula, E is the percentage of the expected efficacy when using the nitrophenol compound and the bactericidal compound at the respective concentrations p and q. x represents the degree of effectiveness when a nitrophenol compound is used at a concentration p, and y represents the degree of effectiveness when a bactericidal compound is used at a concentration q.
　上記コルビーの式によって求めた理論値（％）を表１及び表２に併せて示す。表１及び表２における数値は、有効度（％）である。本明細書において、実際に本発明のニトロフェノール化合物及び殺菌活性化合物を混合処理した時の防除効果が、このＥ（期待値）を上回ればその組み合わせは相乗効果を示すといえる。 The theoretical values (%) determined by the above-mentioned Colby's equation are shown together in Table 1 and Table 2. The numerical values in Tables 1 and 2 are effectiveness (%). In the present specification, when the control effect when the nitrophenol compound of the present invention and the bactericidal active compound are actually mixed and treated exceeds this E (expected value), it can be said that the combination exhibits a synergistic effect.
Figure JPOXMLDOC01-appb-T000003
  
Figure JPOXMLDOC01-appb-T000003
  
Figure JPOXMLDOC01-appb-T000004
  
Figure JPOXMLDOC01-appb-T000004
  
　＜試験結果＞
　本発明の相乗的殺菌剤組成物（実施例１～１８）は、防除率（％）の数値（実測値）が、理論値より大きく、相乗効果を有することが分かった。ニトロフェノール化合物と殺菌剤とを併用することにより、既存の殺菌剤のみに比べて、農園芸病原菌に対する防除効果が向上した。 <Test result>
The synergistic fungicidal compositions (Examples 1 to 18) of the present invention were found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value. By using a nitrophenol compound and a bactericide in combination, the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
　試験例２：キュウリうどんこ病に対する効力試験
　７ｃｍポットに培土（商品名：愛菜１号、片倉コープアグリ（株）製）を詰め、キュウリを播種した。第３葉が展開した時点で、生育が中庸な株を選抜し、試験に用いた。薬剤は希釈した後、スプレーヤーによって株あたり４ｍｌをまんべんなく散布し、十分に風乾させた。キュウリうどんこ病(Podosphaera xanthii又はSphaerotheca fuliginea)の胞子懸濁液は1×10５の密度となるようにｐＨ７．０のリン酸バッファーで調製した。胞子懸濁液は株の表面にまんべんなくスプレーヤーで散布処理した。試験区は１試験区あたり３区設置した。昼：２５℃、夜２０℃のハウス内で７日間管理した後、各薬剤の効果を発病面積で評価した。その結果が表３に示す。 Test Example 2 Efficacy Test against Cucumber Powdery Mildew A 7 cm pot was filled with a culture soil (trade name: Aina No. 1, manufactured by Katakura Coop Aggri Co., Ltd.), and a cucumber was sowed. When the third leaf was developed, a strain with moderate growth was selected and used for the test. After dilution of the drug, 4 ml per share was evenly sprayed by sprayer and allowed to air dry thoroughly. A spore suspension of cucumber powdery mildew (Podosphaera xanthii or Sphaerotheca fuliginea) was prepared with a phosphate buffer of pH 7.0 to a density of 1 × 10 5 . The spore suspension was sprayed on the surface of the strain evenly with a sprayer. Three test zones were established per test zone. Day: After managing for 7 days in a house at 25 ° C. and at 20 ° C. at night, the effects of each drug were evaluated by the area of disease onset. The results are shown in Table 3.
　試験例１と同様、コルビーの式によって求めた理論値（％）を表３に併せて示す。表３における数値は、有効度（％）である。 Similar to Test Example 1, theoretical values (%) determined by the Corby equation are shown in Table 3 together. The numerical values in Table 3 are effectiveness (%).
Figure JPOXMLDOC01-appb-T000005
  
Figure JPOXMLDOC01-appb-T000005
  
　＜試験結果＞
　本発明の相乗的殺菌剤組成物（実施例１９）は、防除率（％）の数値（実測値）が、理論値より大きく、相乗効果を有することが分かった。ニトロフェノール化合物と殺菌剤とを併用することにより、既存の殺菌剤のみに比べて、農園芸病原菌に対する防除効果が向上した。 <Test result>
The synergistic bactericide composition (Example 19) of the present invention was found to have a synergetic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value. By using a nitrophenol compound and a bactericide in combination, the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
　試験例３：キュウリうどんこ病に対する効力試験
　７ｃｍポットに培土（商品名：愛菜１号、片倉コープアグリ（株）製）を詰め、キュウリを播種した。第３葉が展開した時点で、生育が中庸な株を選抜し、試験に用いた。下記表４に示す薬剤を、Tween（登録商標）２０の１０重量％水溶液（水溶液は純水を用いた）で溶解した後、スプレーヤーによって株あたり４ｍｌをまんべんなく散布し、十分に風乾させた。キュウリうどんこ病(Podosphaera xanthii)の胞子懸濁液は1×10５の密度となるようにｐＨ７．０のリン酸バッファーで調製した。胞子懸濁液は株の表面にまんべんなくスプレーヤーで散布処理した。試験区は１試験区あたり３区設置した。昼：２５℃、夜２０℃のハウス内で７日間管理した後、各薬剤の効果を発病面積で評価した。その結果が表３に示す。 Test Example 3: Efficacy test against cucumber powdery mildew A culture medium (trade name: Aina No. 1, manufactured by Katakura Coop Aggri Co., Ltd.) was packed in a 7 cm pot and the cucumber was sowed. When the third leaf was developed, a strain with moderate growth was selected and used for the test. The agents shown in Table 4 below were dissolved in a 10% by weight aqueous solution of Tween (registered trademark) 20 (the aqueous solution used pure water), and then 4 ml per strain was evenly sprayed by a sprayer and air-dried sufficiently. A spore suspension of cucumber powdery mildew (Podosphaera xanthii) was prepared with a pH 7.0 phosphate buffer to a density of 1 × 10 5 . The spore suspension was sprayed on the surface of the strain evenly with a sprayer. Three test zones were established per test zone. Day: After managing for 7 days in a house at 25 ° C. and at 20 ° C. at night, the effects of each drug were evaluated by the area of disease onset. The results are shown in Table 3.
　試験例１と同様、コルビーの式によって求めた理論値（％）を表４に併せて示す。表４における数値は、有効度（％）である。 Similar to Test Example 1, theoretical values (%) obtained by the Corby equation are shown in Table 4 together. The numerical values in Table 4 are effectiveness (%).
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
　＜試験結果＞
　本発明の相乗的殺菌剤組成物（実施例２０）は、防除率（％）の数値（実測値）が、理論値より大きく、相乗効果を有することが分かった。ニトロフェノール化合物と殺菌剤とを併用することにより、既存の殺菌剤のみに比べて、農園芸病原菌に対する防除効果が向上した。 <Test result>
The synergistic bactericide composition (Example 20) of the present invention was found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value. By using a nitrophenol compound and a bactericide in combination, the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
　試験例４：アブラナ科黒斑細菌病に対する効力試験
　愛菜1号培土を詰めた１３６穴のセルトレイで生育させた約３.５葉期のハクサイ（無双）に、下記表５に示す所定濃度に調製した薬剤を、スプレーガン（オリンポスPB-408、１.０ kgf/cm2）を用いて、6 ml/8株の散布水量で散布した。散布後は約２５℃に設定した室内（16L/8D）に静置した。散布２日後にアブラナ科黒斑細菌病菌（Pseudomonas cannabina pv. alisalensis)の菌液を噴霧接種した。菌液は蒸留水を用いて１×１０８ cfu/mlとなるように希釈して調製した。接種後のハクサイは２５℃の恒温高湿室に２４時間静置した。その後２５℃のアッセイ室に静置した。接種約７日後に，株全体の発病程度を下記の基準にて調査し，防除価を算出した。
[基準]
0：発病なし
1：葉面積の５%未満に発病が認められる
2：葉面積の５%以上２５%未満に発病が認められる
3：葉面積の２５%以上５０%未満に発病が認められる
4：葉面積の５０%以上に発病が認められる
その結果を表５に示す。 Test Example 4: Efficacy test against cruciferous black spot bacterial disease Prepared at a predetermined concentration shown in the following Table 5 in about 3.5 leaf stage Chinese cabbage grown on a cell tray of 136 holes packed with Aina No. 1 soil The drug was sprayed using a spray gun (Olympos PB-408, 1.0 kgf / cm 2 ) at a spray rate of 6 ml / 8 strain. After spraying, it was allowed to stand in a room (16 L / 8 D) set at about 25 ° C. Two days after the spraying, the cells were spray-inoculated with a fungal solution of Brassicaceae black spot bacteria (Pseudomonas cannabina pv. Alisalensis). The bacterial solution was prepared by diluting it to 1 × 10 8 cfu / ml with distilled water. Chinese cabbage after inoculation was allowed to stand in a constant temperature and humidity room at 25 ° C. for 24 hours. It was then placed in an assay chamber at 25 ° C. About 7 days after inoculation, the incidence of the entire strain was investigated according to the following criteria to calculate the control value.
[Standard]
0: no attack
1: The disease is recognized in less than 5% of the leaf area
2: The disease is detected in 5% or more and less than 25% of the leaf area
3: The disease is recognized in 25% or more and less than 50% of the leaf area
4: Onset is observed in 50% or more of the leaf area. The results are shown in Table 5.
　試験例１と同様、コルビーの式によって求めた理論値（％）を表５に併せて示す。表５における数値は、有効度（％）である。
Figure JPOXMLDOC01-appb-T000007
 Similar to Test Example 1, theoretical values (%) obtained by the Corby equation are shown in Table 5 together. The numerical values in Table 5 are effectiveness (%).
Figure JPOXMLDOC01-appb-T000007
　＜試験結果＞
　本発明の相乗的殺菌剤組成物（実施例２１～２９）は、防除率（％）の数値（実測値）が、理論値より大きく、相乗効果を有することが分かった。ニトロフェノール化合物と殺菌剤とを併用することにより、既存の殺菌剤のみに比べて、農園芸病原菌に対する防除効果が向上した。 <Test result>
The synergistic bactericidal compositions (Examples 21 to 29) of the present invention were found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value. By using a nitrophenol compound and a bactericide in combination, the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.
　試験例５：キュウリうどんこ病に対する効力試験
　愛菜1号培土を詰めた７．５ｃｍポットで１.２葉期まで生育させたキュウリ（品種：鈴成）に、下記表６に示す所定濃度に調製した薬剤を、回転散布塔を用いて、４.５２ ml/株の散布水量で散布した。散布後２日間は２５℃の室内（１６L／８Ｄ）に静置した。散布２日後にキュウリうどんこ病菌（Podosphaera xanthii）分生子懸濁液を２ｍｌ噴霧接種した。分生子懸濁液は第一葉の全体にうどんこ病が発病したキュウリの葉３枚を１００ｍｌの０.０１% Tween（登録商標）２０水溶液に浸し、３０分振とうすることで調整した。接種後は平均２５℃に維持されたハウス内で培養した。接種１１日後に株全体の発病程度を無処理区と比較することで防除価を算出した。その結果を表６に示す。 Test Example 5 Efficacy Test against Cucumber Powdery Mildew Cucumber (variety: Suzunari) grown to 1.2 leaf stage in a 7.5 cm pot packed with Aina No. 1 soil prepared to a predetermined concentration shown in Table 6 below The drug was sprayed at a spray water volume of 4.52 ml / strain using a rotary spray tower. Two days after spraying, it was left in a room (16 L / 8 D) at 25 ° C. Two days after spraying, 2 ml of the conidia suspension of cucumber powdery mildew (Podosphaera xanthi) was sprayed and inoculated. The conidia suspension was prepared by immersing three cucumber leaves affected by powdery mildew on the whole of the first leaf in 100 ml of 0.01% Tween® 20 aqueous solution and shaking for 30 minutes. After inoculation, the cells were cultured in a house maintained at an average of 25 ° C. The control value was calculated by comparing the degree of onset of the entire strain with the untreated area 11 days after inoculation. The results are shown in Table 6.
　試験例１と同様、コルビーの式によって求めた理論値（％）を表６に併せて示す。表６における数値は、有効度（％）である。
Figure JPOXMLDOC01-appb-T000008
 Similar to Test Example 1, theoretical values (%) obtained by the Corby equation are shown together in Table 6. The numerical values in Table 6 are effectiveness (%).
Figure JPOXMLDOC01-appb-T000008
　＜試験結果＞
　本発明の相乗的殺菌剤組成物（実施例３０～３５）は、防除率（％）の数値（実測値）が、理論値より大きく、相乗効果を有することが分かった。ニトロフェノール化合物と殺菌剤とを併用することにより、既存の殺菌剤のみに比べて、農園芸病原菌に対する防除効果が向上した。 <Test result>
The synergistic bactericidal composition (Examples 30 to 35) of the present invention was found to have a synergistic effect, with the numerical value (measured value) of the control rate (%) being larger than the theoretical value. By using a nitrophenol compound and a bactericide in combination, the control effect on agricultural and horticultural pathogens is improved as compared to the existing bactericidal agent alone.

Claims (15)

  1. （Ａ）ニトロフェノール化合物及び（Ｂ）殺菌活性化合物を含有する相乗的殺菌剤組成物。 A synergistic germicidal composition comprising (A) a nitrophenol compound and (B) a germicidally active compound.
  2. （Ｂ）殺菌活性化合物が、
    （ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）、
    （ｂ２）β－チューブリン重合阻害剤（Ｂ１、２、３）、
    （ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）、
    （ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、
    （ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、
    （ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、
    （ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）、
    （ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）、
    （ｂ９）リン脂質生合成のメチルトランスフェラーゼ阻害剤（Ｆ２）、
    （ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）、
    （ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）、
    （ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）、
    （ｂ１３）セルロース合成酵素阻害剤（Ｈ５）、
    （ｂ１４）メラニン生合成における還元酵素阻害剤（Ｉ１）、
    （ｂ１５）メラニン生合成における脱水酵素阻害剤（Ｉ２）、
    （ｂ１６）メラニン生合成におけるポリケチド合成阻害剤（Ｉ３）、
    （ｂ１７）多作用点を標的とする化合物（Ｍ１～１１）、
    （ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、２、３、４、７）、及び
    （ｂ１９）作用機序が不明の化合物（Ｕ）
    からなる群より選ばれる少なくとも１種の化合物である、請求項１に記載の相乗的殺菌剤組成物。     (B) a bactericidal compound is
    (B1) RNA polymerase inhibitor (A1),
    (B2) β-tubulin polymerization inhibitor (B1, 2, 3),
    (B3) Delocalizer for spectrin-like protein (B5),
    (B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2),
    (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3),
    (B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4),
    (B7) uncoupling agent (C5) in oxidative phosphorylation
    (B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8),
    (B9) a methyltransferase inhibitor of phospholipid biosynthesis (F2),
    (B10) Cell membrane permeable fatty acid (F4),
    (B11) lipid homeostasis, metastasis, storage inhibitor (F9),
    (B12) Demethylation inhibitor of C14 position in sterol biosynthesis (G1),
    (B13) Cellulose synthetase inhibitor (H5),
    (B14) Reductase inhibitor (I1) in melanin biosynthesis
    (B15) An inhibitor of dehydration enzyme (I2) in melanin biosynthesis
    (B16) Polyketide synthesis inhibitor in melanin biosynthesis (I3),
    (B17) Compounds (M1 to 11) targeting multiple action points,
    (B18) Resistance inducer of host plant (P1, 2, 3, 4, 7), and (b19) Compound (U) whose mechanism of action is unknown
    The synergistic germicidal composition according to claim 1, which is at least one compound selected from the group consisting of
  3. （Ｂ）殺菌活性化合物が、
    （ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）、
    （ｂ２）β－チューブリン重合阻害剤（Ｂ３）、
    （ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）、
    （ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）、
    （ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）、
    （ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）、
    （ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）、
    （ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）、
    （ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）、
    （ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）、
    （ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）、
    （ｂ１３）セルロース合成酵素阻害剤（Ｈ５）、
    （ｂ１７）多作用点を標的とする化合物（Ｍ１、３、５）、
    （ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、７）、
    （ｂ１９）シモキサニル、テクロフタラム、シフルフェナミド、フルチアニル、フェリムゾン、テブフロキン、バリダマイシン、トリアゾキシド、フルスルファミド、ジクロメジン、ドジン、メトラフェノン、ピリオフェノン、及び、ピカルブトラゾックス（Ｕ）
    からなる群より選ばれる少なくとも１種の化合物である、請求項１又は２に記載の相乗的殺菌剤組成物。     (B) a bactericidal compound is
    (B1) RNA polymerase inhibitor (A1),
    (B2) β-tubulin polymerization inhibitor (B3),
    (B3) Delocalizer for spectrin-like protein (B5),
    (B4) respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2),
    (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3),
    (B6) respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4),
    (B7) uncoupling agent (C5) in oxidative phosphorylation
    (B8) respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8),
    (B10) Cell membrane permeable fatty acid (F4),
    (B11) lipid homeostasis, metastasis, storage inhibitor (F9),
    (B12) Demethylation inhibitor of C14 position in sterol biosynthesis (G1),
    (B13) Cellulose synthetase inhibitor (H5),
    (B17) Compounds (M1, 3, 5) targeting multiple action points,
    (B18) Resistance inducer of host plant (P1, 7),
    (B19) Shimoxanil, teclophthalam, cyflufenamide, flutianil, ferimsone, tebufloquine, validamycin, triazoloxide, flusulfamide, diclomedin, dodine, metraphenone, pyriophenone, and picalbutrazox (U)
    The synergistic germicidal composition according to claim 1 or 2, which is at least one compound selected from the group consisting of
  4. 前記（ｂ１）ＲＮＡポリメラーゼ阻害剤（Ａ１）が、アシルアラニン化合物；
    （ｂ２）β－チューブリン重合阻害剤（Ｂ３）が、エチルアミノチアゾールカルボキサミド化合物；
    （ｂ３）スペクトリン様タンパク質の非局在化剤（Ｂ５）が、ピリジニルメチルベンゾアミド化合物；
    （ｂ４）呼吸鎖複合体II（コハク酸脱水素酵素）阻害剤（Ｃ２）が、ピリジンカルボキサミド化合物；
    （ｂ５）呼吸鎖複合体III（ユビキノールオキシダーゼ、Qo site）阻害剤（Ｃ３）が、メトキシカーバメート化合物、メトキシアクリレート化合物、及びオキシイミノ酢酸化合物、オキサゾリジンジオン化合物；
    （ｂ６）呼吸鎖複合体III（ユビキノンレダクターゼ、Qi site）阻害剤（Ｃ４）が、シアノイミダゾール化合物；
    （ｂ７）酸化的リン酸化における脱共役剤（Ｃ５）が、２，６－ジニトロアニリン化合物；
    （ｂ８）呼吸鎖複合体III（ユビキノンレダクターゼ、Qo site）阻害剤（Ｃ８）が、トリアゾロピリミジルアミン化合物；
    （ｂ１０）細胞膜浸透性の脂肪酸（Ｆ４）が、カーバメート化合物；
    （ｂ１１）脂質の恒常性、転移、貯蔵の阻害剤（Ｆ９）が、ピペリジニルチアゾールイソオキサゾリン化合物；
    （ｂ１２）ステロール生合成におけるＣ１４位の脱メチル化阻害剤（Ｇ１）が、トリアゾール化合物、及びイミダゾール化合物；
    （ｂ１３）セルロース合成酵素阻害剤（Ｈ５）が、桂皮酸アミド化合物、及びマンデル酸アミド化合物；
    （ｂ１７）多作用点を標的とする化合物（Ｍ１、３、５）が、銅化合物、ジチオカーバメート化合物、及びクロロニトリル化合物；
    （ｂ１８）宿主植物の抵抗性誘導剤（Ｐ１、７）が、ベンゾチアジアゾール化合物、エチルホスホナート化合物、及びクロロニトリル化合物；並びに
    （ｂ１９）作用機序が不明の化合物（Ｕ）がシアノアセトアミドオキシム化合物である、請求項３に記載の相乗的殺菌剤組成物。     Said (b1) RNA polymerase inhibitor (A1) is an acyl alanine compound;
    (B2) β-tubulin polymerization inhibitor (B3) is an ethylaminothiazole carboxamide compound;
    (B3) The delocalizing agent for spectrin-like protein (B5) is a pyridinyl methyl benzamide compound;
    (B4) a respiratory chain complex II (succinic acid dehydrogenase) inhibitor (C2) is a pyridine carboxamide compound;
    (B5) Respiratory chain complex III (ubiquinol oxidase, Qo site) inhibitor (C3) is a methoxycarbamate compound, a methoxyacrylate compound, and an oximinoacetic acid compound, an oxazolidinedione compound;
    (B6) Respiratory chain complex III (ubiquinone reductase, Qi site) inhibitor (C4) is a cyanoimidazole compound;
    (B7) The uncoupling agent (C5) in oxidative phosphorylation is a 2,6-dinitroaniline compound;
    (B8) Respiratory chain complex III (ubiquinone reductase, Qo site) inhibitor (C8) is a triazolopyrimidyl amine compound;
    (B10) Cell membrane permeable fatty acid (F4) is a carbamate compound;
    (B11) A lipid homeostasis, transfer, storage inhibitor (F9) is a piperidinyl thiazole isoxazoline compound;
    (B12) A demethylation inhibitor (G1) at the C14 position in sterol biosynthesis, a triazole compound, and an imidazole compound;
    (B13) The cellulose synthase inhibitor (H5) is a cinnamic acid amide compound, and a mandelic acid amide compound;
    (B17) Compounds (M1, 3, 5) targeted to multiple action points are a copper compound, a dithiocarbamate compound, and a chloronitrile compound;
    (B18) A host plant resistance inducer (P1, 7) is a benzothiadiazole compound, an ethylphosphonate compound, and a chloronitrile compound; and (b19) a compound (U) of unknown mechanism of action is a cyanoacetamide oxime compound A synergistic germicidal composition according to claim 3, which is
  5. （Ｂ）殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも1種の化合物である、請求項１～４の何れか一項に記載の相乗的殺菌剤組成物。 (B) The bactericidally active compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cyazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxys Poconazole fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetyl aluminum, phosphorous acid or salts thereof, oxathiapiproline, nonylphenol sulfonic acid The synergistic germicidal composition according to any one of claims 1 to 4, which is at least one compound selected from the group consisting of copper salts and shimoxanyl.
  6. 前記（Ａ）ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、請求項１～５の何れか一項に記載の相乗的殺菌剤組成物。 The synergistic germicidal composition according to any one of claims 1 to 5, wherein the (A) nitrophenol compound is a phenol compound having one nitro group.
  7. （Ａ）ニトロフェノール化合物の配合割合が、（Ｂ）殺菌活性成分１００重量部に対して、１～５０００重量部である、請求項１～６の何れか一項に記載の相乗的殺菌剤組成物。 The synergistic germicidal composition according to any one of claims 1 to 6, wherein the blending ratio of (A) the nitrophenol compound is 1 to 5000 parts by weight with respect to 100 parts by weight of (B) the bactericidal active ingredient. object.
  8. 請求項１～７の何れか一項に記載の相乗的殺菌剤組成物を、農園芸病原菌の生息場所（ヒトを除く）に処理することを特徴とする病原菌防除方法。 A method for controlling pathogens, which comprises treating the synergistic microbicidal composition according to any one of claims 1 to 7 in the habitat of agricultural and horticultural pathogens (except for humans).
  9. 請求項１～７の何れか一項に記載の相乗的殺菌剤組成物を、農園芸病原菌が寄生する植物又はその近傍に処理することを特徴とする植物保護方法。 A plant protection method comprising treating the synergistic bactericidal composition according to any one of claims 1 to 7 to a plant parasitic to agricultural and horticultural pathogens or in the vicinity thereof.
  10. 殺菌活性増強のためのニトロフェノール化合物の使用方法。 Method of using a nitrophenol compound for enhancing bactericidal activity.
  11. 殺菌活性化合物の殺菌活性を増強させるためのニトロフェノール化合物の使用方法（ヒトへの適用を除く）であって、
    前記殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも１種の化合物である、使用方法。     Method of using a nitrophenol compound to enhance the bactericidal activity of a bactericidal active compound (except for human application),
    The bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetylaluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt And at least one compound selected from the group consisting of and simoxanyl.
  12. 前記ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、請求項１０又は１１に記載の使用方法。 The use method according to claim 10 or 11, wherein the nitrophenol compound is a phenol compound having one nitro group.
  13. ニトロフェノール化合物を含有する殺菌活性増強剤。 A bactericidal activity enhancer containing a nitrophenol compound.
  14. 殺菌活性化合物に対して、ニトロフェノール化合物を含有する殺菌活性増強剤であって、
    前記殺菌活性化合物が、メタラキシル、メタラキシルＭ、ボスカリド、ピラクロストロビン、アゾキシストロビン、トリフロキシストロビン、クレソキシムメチル、ピコキシストロビン、シアゾファミド、ファモキサドン、アメトクトラジン、フルアジナム、テトラコナゾール、オキスポコナゾールフマル酸塩、フルトリアホール、クロロタロニル、マンゼブ、ジメトモルフ、マンジプロパミド、エタボキサム、アシベンゾラル－Ｓ－メチル、フルオピコリド、プロパモカルブ塩酸塩、ホセチルアルミニウム、亜リン酸又はその塩、オキサチアピプロリン、ノニルフェノールスルホン酸銅塩、及びシモキサニルからなる群より選ばれる少なくとも１種の化合物である、殺菌活性増強剤。     It is a bactericidal activity enhancer containing a nitrophenol compound for a bactericidally active compound,
    The bactericidal compounds are metalaxyl, metalaxyl M, boscalid, pyraclostrobin, azoxystrobin, trifloxystrobin, clesoxim methyl, picoxystrobin, cazofamid, famoxadone, ametocutrazine, fluazinam, tetraconazole, oxosconazole Fumarate, flutriaphor, chlorothalonil, manzeb, dimethomorph, mandipropamide, etaboxam, acibenzolar-S-methyl, fluopicolide, propamocarb hydrochloride, fosetylaluminum, phosphorous acid or its salt, oxathiapiproline, nonylphenol sulfonic acid copper salt And a bactericidal activity enhancer, which is at least one compound selected from the group consisting of and simoxanyl.
  15. 前記ニトロフェノール化合物が、ニトロ基を１つ有しているフェノール化合物である、請求項１３又は１４に記載の殺菌活性増強剤。 The bactericidal activity enhancer according to claim 13 or 14, wherein the nitrophenol compound is a phenol compound having one nitro group.
PCT/JP2018/047403 2017-12-24 2018-12-23 Synergistic bactericide composition including nitrophenol compound and bactericidally active compound WO2019124565A1 (en)

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