WO2019119672A1 - Healthcare food helping to relieve asthenopia, and preparation method - Google Patents
Healthcare food helping to relieve asthenopia, and preparation method Download PDFInfo
- Publication number
- WO2019119672A1 WO2019119672A1 PCT/CN2018/080838 CN2018080838W WO2019119672A1 WO 2019119672 A1 WO2019119672 A1 WO 2019119672A1 CN 2018080838 W CN2018080838 W CN 2018080838W WO 2019119672 A1 WO2019119672 A1 WO 2019119672A1
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- WIPO (PCT)
- Prior art keywords
- extract
- food
- content
- visual fatigue
- green tea
- Prior art date
Links
- 208000003464 asthenopia Diseases 0.000 title claims abstract description 34
- 235000013305 food Nutrition 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 23
- 229940094952 green tea extract Drugs 0.000 claims abstract description 22
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 22
- 229940052016 turmeric extract Drugs 0.000 claims abstract description 22
- 235000020240 turmeric extract Nutrition 0.000 claims abstract description 22
- 239000008513 turmeric extract Substances 0.000 claims abstract description 22
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 16
- 239000008176 lyophilized powder Substances 0.000 claims abstract description 16
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 12
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims abstract description 11
- 229960005375 lutein Drugs 0.000 claims abstract description 11
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims abstract description 11
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims abstract description 11
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 244000269722 Thea sinensis Species 0.000 claims abstract description 6
- 235000012754 curcumin Nutrition 0.000 claims abstract description 6
- 239000004148 curcumin Substances 0.000 claims abstract description 6
- 229940109262 curcumin Drugs 0.000 claims abstract description 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 6
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 6
- 235000013616 tea Nutrition 0.000 claims abstract description 6
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 claims abstract description 4
- 229920001991 Proanthocyanidin Polymers 0.000 claims abstract description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 30
- 239000002994 raw material Substances 0.000 claims description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 22
- 235000013402 health food Nutrition 0.000 claims description 22
- 244000144927 Aloe barbadensis Species 0.000 claims description 15
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 15
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims description 15
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 15
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 15
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 229940102480 bilberry extract Drugs 0.000 claims description 10
- 235000019209 bilberry extract Nutrition 0.000 claims description 10
- 235000012680 lutein Nutrition 0.000 claims description 10
- 239000001656 lutein Substances 0.000 claims description 10
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 10
- -1 superoxide anions Chemical class 0.000 claims description 9
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 235000006708 antioxidants Nutrition 0.000 claims description 7
- 235000020237 cranberry extract Nutrition 0.000 claims description 7
- 150000004676 glycans Chemical class 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 4
- 244000182216 Mimusops elengi Species 0.000 claims description 4
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 4
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 claims 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 4
- 229910052710 silicon Inorganic materials 0.000 claims 4
- 239000010703 silicon Substances 0.000 claims 4
- 241001674044 Blattodea Species 0.000 claims 3
- 240000004658 Medicago sativa Species 0.000 claims 1
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 210000001508 eye Anatomy 0.000 abstract description 11
- 230000004792 oxidative damage Effects 0.000 abstract description 6
- 241001106041 Lycium Species 0.000 abstract description 2
- 235000016357 Mirtillo rosso Nutrition 0.000 abstract 2
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 abstract 2
- 244000077923 Vaccinium vitis idaea Species 0.000 abstract 2
- 241001116389 Aloe Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000008518 lycium barbarum polysaccharide Substances 0.000 abstract 1
- 235000008210 xanthophylls Nutrition 0.000 abstract 1
- 206010036790 Productive cough Diseases 0.000 description 8
- 208000024794 sputum Diseases 0.000 description 8
- 210000003802 sputum Anatomy 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- 150000003254 radicals Chemical class 0.000 description 7
- CMFNMSMUKZHDEY-UHFFFAOYSA-M peroxynitrite Chemical group [O-]ON=O CMFNMSMUKZHDEY-UHFFFAOYSA-M 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 229940074551 lutein 5 mg Drugs 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 230000002000 scavenging effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000002292 Radical scavenging effect Effects 0.000 description 2
- 241000239226 Scorpiones Species 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229940047375 bilberry extract 40 mg Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 1
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229940055986 lutein 2 mg Drugs 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
- 229940069774 quince extract Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229940030961 sorghum extract Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the invention belongs to the technical field of health care products, and particularly relates to a health food and a preparation method thereof, which are helpful for relieving visual fatigue.
- Visual fatigue is a common eye disease. It is not an independent disease. It is a fatigue syndrome caused by many factors. It is usually characterized by eye pain, soreness, foreign body sensation, blurred vision, dry eyes, etc. .
- the causes of visual fatigue are complex. Common predisposing factors include diseases of the eye itself, such as myopia, keratitis, macular degeneration, etc. In addition, environmental factors are the main factors causing visual fatigue, such as glare or ultraviolet rays. Long-term use of radiation from electronic products, etc., will produce excessive free radicals, causing oxidative damage to the eyes.
- the present invention develops a product that can relieve visual fatigue products from the cause by adjusting the physiological function of the human body. Lipid peroxidation in the eye effectively removes free radical damage to the eye tissue, thereby protecting vision and helping to alleviate visual fatigue.
- the present invention provides a health food and a preparation method thereof which are useful for relieving visual fatigue.
- a health food for helping to alleviate visual fatigue the food consists mainly of the following components in percentage by mass: bilberry extract 5% to 60%, lutein 0.5% to 35%, green tea extract 1% to 40% , aloe vera gel lyophilized powder 200:1 0.1% ⁇ 30%, turmeric extract 0.2% ⁇ 20%, medlar extract 0.5% ⁇ 35%, wherein the bilberry extract proanthocyanidin content ⁇ 20%,
- the tea polyphenol content in the green tea extract is ⁇ 90%
- the curcumin content in the turmeric extract is ⁇ 90%
- the scorpion polysaccharide content in the sputum extract is ⁇ 25%.
- the food product further comprises 10% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and 5% to 30% of silicon dioxide.
- the food is mainly composed of the following components in mass percentage: 10% to 50% of cranberry extract, 1% to 30% of lutein, 1% to 30% of green tea extract, and lyophilized powder of aloe vera gel 200 : 1 0.5% to 20%, turmeric extract 1% to 20%, and medlar extract 0.5% to 20%.
- the food product is mainly composed of the following components in mass percentage: 10% to 30% of cranberry extract, 1% to 20% of lutein, 1% to 20% of green tea extract, and lyophilized powder of aloe vera gel 200 : 1 0.8% to 15%, turmeric extract 2% to 20%, and sputum extract 0.6% to 15%.
- the food product is mainly composed of the following components in mass percentage: bilberry extract 11% to 20%, lutein 1% to 10%, green tea extract 1% to 15%, aloe vera gel lyophilized powder 200 : 1 1% to 13%, turmeric extract 2% to 10%, and sputum extract 0.7% to 10%.
- the food product further comprises 10% to 45% of microcrystalline cellulose, 5% to 20% of magnesium stearate, and 5% to 25% of silicon dioxide.
- the food product further comprises 11% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and 10% to 25% of silicon dioxide.
- the food product further comprises 12% to 45% of microcrystalline cellulose, 5% to 15% of magnesium stearate, and 15% to 25% of silicon dioxide.
- the food product is used to avoid oxidative damage to the eye by peroxy radicals, hydroxyl radicals, superoxide anions, singlet oxygen, and peroxynitrite groups.
- the method for preparing a comprehensive antioxidant health food product comprises the following steps,
- bilberry extract 5% ⁇ 60%, lutein 0.5% ⁇ 35%, green tea extract 1% ⁇ 40%, aloe vera gel lyophilized powder 200: 10.1% ⁇ 30%, turmeric extract 0.2% ⁇ 20%, ⁇ extract 0.5% ⁇ 35%, wherein the bilberry extract has procyanidin content ⁇ 20%, and the tea polyphenol content in the green tea extract is ⁇ 90% The curcumin content in the turmeric extract is ⁇ 90%, and the scorpion polysaccharide content in the sorghum extract is ⁇ 25%;
- auxiliary materials adding auxiliary materials in S3 for remixing, granulating and drying to prepare a desired capsule dosage form or tablet
- the auxiliary material further comprising microcrystalline cellulose 10% to 50%, magnesium stearate 5 % to 30%, and 5% to 30% of silica.
- the invention has the beneficial effects that the invention combines various natural antioxidants to meet various nutrients required by the eyes, and at the same time, can prevent the damage caused by excessive free radicals to the eyes, and exert synergistic effects on relieving visual fatigue, and Through reliable scientific methods to verify the different free radical scavenging ability, compared with the existing health foods that alleviate the visual fatigue function, it can fundamentally alleviate visual fatigue, inhibit the formation of excessive free radicals, and effectively scavenge free radicals on the eyeball tissue. The damage, thus protecting vision, helps to alleviate visual fatigue.
- the technical solution of the present invention is specifically described below in conjunction with the embodiments.
- the present invention discloses a health food that helps relieve visual fatigue, and the ability to relieve visual fatigue includes preventing peroxy radicals, hydroxyl radicals, superoxide anions, Oxidative damage to the eye by singlet oxygen and peroxynitrite.
- the content of proanthocyanidins in the cranberry extract is ⁇ 20%
- the content of tea polyphenols in the green tea extract is ⁇ 90%
- the content of curcumin in the turmeric extract is ⁇ 90%
- the content of lycium polysaccharide in the quince extract is ⁇ 25%.
- a health food having a function of relieving visual fatigue prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 2 mg, green tea extract 35 mg, aloe vera gel lyophilized powder 5 mg, turmeric extract 1 mg, 7 mg of sputum extract, 140 mg of microcrystalline cellulose, 53 mg of magnesium stearate, and 59 mg of silica.
- the raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
- a health food having a function of relieving visual fatigue prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 5 mg, green tea extract 5 mg, aloe vera gel lyophilized powder 35 mg, turmeric extract 2 mg, sputum extract 3 mg, microcrystalline cellulose 140 mg, magnesium stearate 43 mg, and silica 69 mg.
- the raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
- a health food having a function of relieving visual fatigue prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 5 mg, green tea extract 15 mg, aloe vera gel lyophilized powder 13 mg, turmeric extract 2 mg, 15 mg of sputum extract, 150 mg of microcrystalline cellulose, 33 mg of magnesium stearate, 69 mg of silica.
- the raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
- a health food having a function of relieving visual fatigue which is prepared by mass percentage of the following raw materials: bilberry extract 40 mg, lutein 5 mg, green tea extract 5 mg, aloe vera gel lyophilized powder 35 mg, turmeric extract 2 mg, 11 mg of sputum extract, 145 mg of microcrystalline cellulose, 43 mg of magnesium stearate, and 64 mg of silica.
- the raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
- a health food having a function of relieving visual fatigue which is prepared by mass percentage of the following raw materials: bilberry extract 40 mg, lutein 5 mg, green tea extract 35 mg, aloe vera gel lyophilized powder 8 mg, turmeric extract 2 mg, sputum extract 8 mg, microcrystalline cellulose 135 mg, magnesium stearate 43 mg, and silica 74 mg.
- the raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
- the auxiliary material in the invention is similar to the preparation of the capsule or the tablet in the prior art, and other diluents, lubricants, glidants and the like required for capsules and tablets can be used according to specific needs, and no specific refinement is performed here. .
- the invention also discloses that based on the ORAC 5.0 analysis technology, the functions of the first to sixth embodiments of the present invention are evaluated and tested. It was finally verified that it can eliminate the oxidative damage of the eyes caused by excessive peroxygen free radicals, hydroxyl radicals, superoxide anions, singlet oxygen and peroxynitrite.
- ORAC 5.0 analysis technology is: adding a detector (fluorescent probe) and a reactive oxygen/reactive nitrogen (ROS/RNS) generator (substrate) to the sample (antioxidant), and ROS/RNS attacks the fluorescent probe to produce Fluorescence changes (increased or weakened fluorescence), once acted upon by antioxidants, the antioxidants in the system competitively inhibit the detection agent from reacting with the substrate, thereby inhibiting changes in fluorescence.
- This method uses Trolox as a positive control to evaluate the ROS/RNS scavenging ability of the sample (antioxidant) in combination with changes in fluorescence intensity.
- the free radical scavenging ability of the inventive health food examples 1 to 6 was evaluated and tested by the technique, and the ORAC value (peroxy radical scavenging ability) was 950 to 1730 ⁇ mol TE/g, and the HORAC value (hydroxy radical scavenging ability) was used.
- SORAC value (superoxide anion scavenging ability) is 1405 ⁇ 8840 ⁇ mol TE/g
- SOAC value single-line oxygen scavenging capacity
- NORAC value peroxynitrite removal ability
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed are a healthcare food which helps to relieve asthenopia, and a preparation method. The healthcare food is mainly composed of the following ingredients by mass percentage: 5%-60% of a cowberry extract, 0.5%-35% of xanthophyll, 1%-40% of a green tea extract, 0.1%-30% of an aloe gel lyophilized powder 200:1, 0.2%-20% of a turmeric extract, and 0.5%-35% of a Lycium barbarrum extract, wherein the content of proanthocyanidin in the cowberry extract is ≥20%, the content of tea polyphenol in the green tea extract is ≥90%, the content of curcumin in the turmeric extract is ≥90%, and the content of Lycium barbarum polysaccharide in the Lycium barbarum extract is ≥25%. The healthcare food is used in preventing oxidative damage to eyes caused by free radicals. The food can be prepared into capsules and tablets.
Description
本发明属于保健品技术领域,具体涉及一种有助于缓解视疲劳保健食品及制备方法。The invention belongs to the technical field of health care products, and particularly relates to a health food and a preparation method thereof, which are helpful for relieving visual fatigue.
视疲劳是一种常见的眼科疾病,该疾病并不是独立存在的,而是由于多种因素引起的疲劳综合征,通常表现为眼部疼痛、酸胀、异物感、视物模糊、眼睛干涩等。Visual fatigue is a common eye disease. It is not an independent disease. It is a fatigue syndrome caused by many factors. It is usually characterized by eye pain, soreness, foreign body sensation, blurred vision, dry eyes, etc. .
视疲劳成因复杂,常见的诱发因素主要包括眼睛本身的疾病,例如近视、角膜炎、黄斑变性等;除此之外,环境因素是目前引起视疲劳的主要因素,例如:强光或紫外线照射眼睛、长期使用电子产品带来的辐射等,都会产生过量的自由基,对眼睛造成氧化损伤。The causes of visual fatigue are complex. Common predisposing factors include diseases of the eye itself, such as myopia, keratitis, macular degeneration, etc. In addition, environmental factors are the main factors causing visual fatigue, such as glare or ultraviolet rays. Long-term use of radiation from electronic products, etc., will produce excessive free radicals, causing oxidative damage to the eyes.
目前国内缓解视疲劳的保健食品大多只能缓解视疲劳症状,并不能从成因上解决视疲劳问题,因此,本发明开发了一种通过调节人体生理机能,可以从成因上缓解视疲劳产品,防止眼部脂质过氧化,有效清除自由基对眼球组织的伤害,从而保护视力,有助于缓解视疲劳。At present, most of the health foods for relieving visual fatigue in China can only alleviate the symptoms of visual fatigue, and can not solve the problem of visual fatigue from the cause. Therefore, the present invention develops a product that can relieve visual fatigue products from the cause by adjusting the physiological function of the human body. Lipid peroxidation in the eye effectively removes free radical damage to the eye tissue, thereby protecting vision and helping to alleviate visual fatigue.
发明内容Summary of the invention
为了解决现有技术的不足,本发明提供了一种有助于缓解视疲劳保健食品及制备方法。In order to solve the deficiencies of the prior art, the present invention provides a health food and a preparation method thereof which are useful for relieving visual fatigue.
本发明的目的通过以下技术方案来实现:The object of the invention is achieved by the following technical solutions:
一种有助于缓解视疲劳保健食品,所述食品主要由以下成分按质量百分比组成:越橘提取物5%~60%,叶黄素0.5%~35%,绿茶提取物1%~40%,芦荟凝胶冻干粉200:1 0.1%~30%,姜黄提取物0.2%~20%,枸杞提取物0.5%~35%,其中,所述越橘提取物中原花青 素含量≥20%,所述绿茶提取物中茶多酚含量≥90%,所述姜黄提取物中姜黄素含量≥90%,所述枸杞提取物中枸杞多糖含量≥25%。A health food for helping to alleviate visual fatigue, the food consists mainly of the following components in percentage by mass: bilberry extract 5% to 60%, lutein 0.5% to 35%, green tea extract 1% to 40% , aloe vera gel lyophilized powder 200:1 0.1% ~ 30%, turmeric extract 0.2% ~ 20%, medlar extract 0.5% ~ 35%, wherein the bilberry extract proanthocyanidin content ≥ 20%, The tea polyphenol content in the green tea extract is ≥90%, the curcumin content in the turmeric extract is ≥90%, and the scorpion polysaccharide content in the sputum extract is ≥25%.
优选地,所述食品中还包括微晶纤维素10%~50%,硬脂酸镁5%~30%,二氧化硅5%~30%。Preferably, the food product further comprises 10% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and 5% to 30% of silicon dioxide.
优选地,所述食品主要由以下成分按质量百分比组成:越橘提取物10%~50%,叶黄素1%~30%,绿茶提取物1%~30%,芦荟凝胶冻干粉200:1 0.5%~20%,姜黄提取物1%~20%,枸杞提取物0.5%~20%。Preferably, the food is mainly composed of the following components in mass percentage: 10% to 50% of cranberry extract, 1% to 30% of lutein, 1% to 30% of green tea extract, and lyophilized powder of aloe vera gel 200 : 1 0.5% to 20%, turmeric extract 1% to 20%, and medlar extract 0.5% to 20%.
优选地,所述食品主要由以下成分按质量百分比组成:越橘提取物10%~30%,叶黄素1%~20%,绿茶提取物1%~20%,芦荟凝胶冻干粉200:1 0.8%~15%,姜黄提取物2%~20%,枸杞提取物0.6%~15%。Preferably, the food product is mainly composed of the following components in mass percentage: 10% to 30% of cranberry extract, 1% to 20% of lutein, 1% to 20% of green tea extract, and lyophilized powder of aloe vera gel 200 : 1 0.8% to 15%, turmeric extract 2% to 20%, and sputum extract 0.6% to 15%.
优选地,所述食品主要由以下成分按质量百分比组成:越橘提取物11%~20%,叶黄素1%~10%,绿茶提取物1%~15%,芦荟凝胶冻干粉200:1 1%~13%,姜黄提取物2%~10%,枸杞提取物0.7%~10%。Preferably, the food product is mainly composed of the following components in mass percentage: bilberry extract 11% to 20%, lutein 1% to 10%, green tea extract 1% to 15%, aloe vera gel lyophilized powder 200 : 1 1% to 13%, turmeric extract 2% to 10%, and sputum extract 0.7% to 10%.
优选地,所述食品中还包括微晶纤维素10%~45%,硬脂酸镁5%~20%,二氧化硅5%~25%。Preferably, the food product further comprises 10% to 45% of microcrystalline cellulose, 5% to 20% of magnesium stearate, and 5% to 25% of silicon dioxide.
优选地,所述食品中还包括微晶纤维素11%~50%,硬脂酸镁5%~30%,二氧化硅10%~25%。Preferably, the food product further comprises 11% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and 10% to 25% of silicon dioxide.
优选地,所述食品中还包括微晶纤维素12%~45%,硬脂酸镁5%~15%,二氧化硅15%~25%。Preferably, the food product further comprises 12% to 45% of microcrystalline cellulose, 5% to 15% of magnesium stearate, and 15% to 25% of silicon dioxide.
优选地,所述食品用于避免过氧自由基、羟自由基、超氧阴离子、单线态氧、过氧亚硝酸基对眼部的氧化损坏。Preferably, the food product is used to avoid oxidative damage to the eye by peroxy radicals, hydroxyl radicals, superoxide anions, singlet oxygen, and peroxynitrite groups.
优选地,所述的一种全面抗氧化保健食品的制备方法,包括如下步骤,Preferably, the method for preparing a comprehensive antioxidant health food product comprises the following steps,
S1、原料准备,按质量百分比称取原料:越橘提取物5%~60%, 叶黄素0.5%~35%,绿茶提取物1%~40%,芦荟凝胶冻干粉200:10.1%~30%,姜黄提取物0.2%~20%,枸杞提取物0.5%~35%,其中,所述越橘提取物中原花青素含量≥20%,所述绿茶提取物中茶多酚含量≥90%,所述姜黄提取物中姜黄素含量≥90%,所述枸杞提取物中枸杞多糖含量≥25%;S1, raw material preparation, weigh the raw materials by mass percentage: bilberry extract 5% ~ 60%, lutein 0.5% ~ 35%, green tea extract 1% ~ 40%, aloe vera gel lyophilized powder 200: 10.1% ~30%, turmeric extract 0.2%~20%, 枸杞 extract 0.5%~35%, wherein the bilberry extract has procyanidin content ≥20%, and the tea polyphenol content in the green tea extract is ≥90% The curcumin content in the turmeric extract is ≥90%, and the scorpion polysaccharide content in the sorghum extract is ≥25%;
S2、筛选,将准备好的原料并经过70-90目筛进行筛选,选出粒度均匀的原料待用;S2, screening, the prepared raw materials are screened through a 70-90 mesh sieve, and the raw materials with uniform particle size are selected for use;
S3、混合,将过筛后的原料按照等量递增的方法混合均匀;S3, mixing, mixing the sieved raw materials in an equal amount of increasing manner;
S4、辅料添加,在S3中加入辅料进行再次混合,制粒,干燥,制备成所需的胶囊剂型或片剂,所述辅料还包括微晶纤维素10%~50%,硬脂酸镁5%~30%,二氧化硅5%~30%。S4, adding auxiliary materials, adding auxiliary materials in S3 for remixing, granulating and drying to prepare a desired capsule dosage form or tablet, the auxiliary material further comprising microcrystalline cellulose 10% to 50%, magnesium stearate 5 % to 30%, and 5% to 30% of silica.
本发明的有益效果体现在:本发明以多种天然抗氧化物进行组合,满足了眼睛所需的多种营养,同时能够防止过量自由基对眼睛造成的危害,发挥协同缓解视疲劳作用,并通过可靠的科学方法对不同自由基清除能力进行验证,与现有的缓解视疲劳功能的保健食品相比较,可以从根本上缓解视疲劳,抑制过量自由基的形成,有效清除自由基对眼球组织的伤害,从而保护视力,有助于缓解视疲劳。The invention has the beneficial effects that the invention combines various natural antioxidants to meet various nutrients required by the eyes, and at the same time, can prevent the damage caused by excessive free radicals to the eyes, and exert synergistic effects on relieving visual fatigue, and Through reliable scientific methods to verify the different free radical scavenging ability, compared with the existing health foods that alleviate the visual fatigue function, it can fundamentally alleviate visual fatigue, inhibit the formation of excessive free radicals, and effectively scavenge free radicals on the eyeball tissue. The damage, thus protecting vision, helps to alleviate visual fatigue.
以下结合实施例具体阐述本发明的技术方案,本发明揭示了一种有助于缓解视疲劳的保健食品,所述的缓解视疲劳能力包括防止过氧自由基、羟自由基、超氧阴离子、单线态氧、过氧亚硝酸盐对眼部的氧化损伤。同时,以下实施例中越橘提取物中原花青素含量≥20%,绿茶提取物中茶多酚含量≥90%,姜黄提取物中姜黄素含量≥90%,枸杞提取物中枸杞多糖含量≥25%。The technical solution of the present invention is specifically described below in conjunction with the embodiments. The present invention discloses a health food that helps relieve visual fatigue, and the ability to relieve visual fatigue includes preventing peroxy radicals, hydroxyl radicals, superoxide anions, Oxidative damage to the eye by singlet oxygen and peroxynitrite. Meanwhile, in the following examples, the content of proanthocyanidins in the cranberry extract is ≥20%, the content of tea polyphenols in the green tea extract is ≥90%, the content of curcumin in the turmeric extract is ≥90%, and the content of lycium polysaccharide in the quince extract is ≥25%.
实施例1Example 1
一种具有有助于缓解视疲劳功能的保健食品,按质量百分比用下 述原料制成:越橘提取物48mg,叶黄素2mg,绿茶提取物35mg,芦荟凝胶冻干粉5mg,姜黄提取物1mg,枸杞提取物7mg,微晶纤维素140mg,硬脂酸镁53mg,二氧化硅59mg。将所述原料过80目筛,将过筛后的原料按照等量递增混合后,加入辅料,制粒,干燥,按照常规工艺制备成胶囊剂型或片剂。A health food having a function of relieving visual fatigue, prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 2 mg, green tea extract 35 mg, aloe vera gel lyophilized powder 5 mg, turmeric extract 1 mg, 7 mg of sputum extract, 140 mg of microcrystalline cellulose, 53 mg of magnesium stearate, and 59 mg of silica. The raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
实施例2Example 2
一种具有有助于缓解视疲劳功能的保健食品,按质量百分比用下述原料制成:越橘提取物48mg,叶黄素5mg,绿茶提取物5mg,芦荟凝胶冻干粉35mg,姜黄提取物2mg,枸杞提取物3mg,微晶纤维素140mg,硬脂酸镁43mg,二氧化硅69mg。将所述原料过80目筛,将过筛后的原料按照等量递增混合后,加入辅料,制粒,干燥,按照常规工艺制备成胶囊剂型或片剂。A health food having a function of relieving visual fatigue, prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 5 mg, green tea extract 5 mg, aloe vera gel lyophilized powder 35 mg, turmeric extract 2 mg, sputum extract 3 mg, microcrystalline cellulose 140 mg, magnesium stearate 43 mg, and silica 69 mg. The raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
实施例3Example 3
一种具有有助于缓解视疲劳功能的保健食品,按质量百分比用下述原料制成:越橘提取物48mg,叶黄素5mg,绿茶提取物15mg,芦荟凝胶冻干粉13mg,姜黄提取物2mg,枸杞提取物15mg,微晶纤维素150mg,硬脂酸镁33mg,二氧化硅69mg。将所述原料过80目筛,将过筛后的原料按照等量递增混合后,加入辅料,制粒,干燥,按照常规工艺制备成胶囊剂型或片剂。A health food having a function of relieving visual fatigue, prepared by mass percentage of the following raw materials: bilberry extract 48 mg, lutein 5 mg, green tea extract 15 mg, aloe vera gel lyophilized powder 13 mg, turmeric extract 2 mg, 15 mg of sputum extract, 150 mg of microcrystalline cellulose, 33 mg of magnesium stearate, 69 mg of silica. The raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
实施例4Example 4
一种具有有助于缓解视疲劳功能的保健食品,按质量百分比用下述原料制成:越橘提取物40mg,叶黄素5mg,绿茶提取物5mg,芦荟凝胶冻干粉35mg,姜黄提取物2mg,枸杞提取物11mg,微晶纤维素145mg,硬脂酸镁43mg,二氧化硅64mg。将所述原料过80目筛,将过筛后的原料按照等量递增混合后,加入辅料,制粒,干燥,按照 常规工艺制备成胶囊剂型或片剂。A health food having a function of relieving visual fatigue, which is prepared by mass percentage of the following raw materials: bilberry extract 40 mg, lutein 5 mg, green tea extract 5 mg, aloe vera gel lyophilized powder 35 mg, turmeric extract 2 mg, 11 mg of sputum extract, 145 mg of microcrystalline cellulose, 43 mg of magnesium stearate, and 64 mg of silica. The raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
实施例5Example 5
一种具有有助于缓解视疲劳功能的保健食品,按质量百分比用下述原料制成:越橘提取物40mg,叶黄素5mg,绿茶提取物35mg,芦荟凝胶冻干粉8mg,姜黄提取物2mg,枸杞提取物8mg,微晶纤维素135mg,硬脂酸镁43mg,二氧化硅74mg。将所述原料过80目筛,将过筛后的原料按照等量递增混合后,加入辅料,制粒,干燥,按照常规工艺制备成胶囊剂型或片剂。A health food having a function of relieving visual fatigue, which is prepared by mass percentage of the following raw materials: bilberry extract 40 mg, lutein 5 mg, green tea extract 35 mg, aloe vera gel lyophilized powder 8 mg, turmeric extract 2 mg, sputum extract 8 mg, microcrystalline cellulose 135 mg, magnesium stearate 43 mg, and silica 74 mg. The raw material is passed through an 80 mesh sieve, and the sieved raw materials are mixed in an equal amount, added with an auxiliary material, granulated, dried, and prepared into a capsule form or tablet according to a conventional process.
本发明中的辅料与现有技术中制备胶囊或片剂类似,可以根据具体需求采用其他用于胶囊、片剂所需的稀释剂、润滑剂、助流剂等,在此不做具体细化。The auxiliary material in the invention is similar to the preparation of the capsule or the tablet in the prior art, and other diluents, lubricants, glidants and the like required for capsules and tablets can be used according to specific needs, and no specific refinement is performed here. .
本发明还揭示了一种以ORAC 5.0分析技术为依托,对本实施例1~6有助于缓解视疲劳功能进行了评价和测试。最终验证了能够消除过量过氧自由基、羟自由基、超氧阴离子、单线态氧、过氧亚硝酸盐对眼部的氧化损伤。The invention also discloses that based on the ORAC 5.0 analysis technology, the functions of the first to sixth embodiments of the present invention are evaluated and tested. It was finally verified that it can eliminate the oxidative damage of the eyes caused by excessive peroxygen free radicals, hydroxyl radicals, superoxide anions, singlet oxygen and peroxynitrite.
ORAC 5.0分析技术法原理为:将检测剂(荧光探针)和活性氧/活性氮(ROS/RNS)产生剂(底物)加入样品(抗氧化剂)中,ROS/RNS攻击荧光探针,产生荧光变化(荧光强度增强或减弱),一旦受到抗氧化剂作用,体系中的抗氧化剂竞争性抑制检测剂与底物反应,从而抑制荧光变化。该方法以Trolox作为阳性对照,结合荧光强度的变化评价样品(抗氧化剂)的ROS/RNS清除能力。The principle of ORAC 5.0 analysis technology is: adding a detector (fluorescent probe) and a reactive oxygen/reactive nitrogen (ROS/RNS) generator (substrate) to the sample (antioxidant), and ROS/RNS attacks the fluorescent probe to produce Fluorescence changes (increased or weakened fluorescence), once acted upon by antioxidants, the antioxidants in the system competitively inhibit the detection agent from reacting with the substrate, thereby inhibiting changes in fluorescence. This method uses Trolox as a positive control to evaluate the ROS/RNS scavenging ability of the sample (antioxidant) in combination with changes in fluorescence intensity.
通过该技术对所发明保健食品实施例1~6的自由基清除能力进行了评价和测试,ORAC值(过氧自由基清除能力)在950~1730μmolTE/g,HORAC值(羟基自由基清除能力)在2260~6090μmolTE/g,SORAC值(超氧阴离子清除能力)在1405~8840 μmolTE/g,SOAC值(单线态氧清除能力)在4410~12040μmolTE/g,NORAC值(过氧亚硝基清除能力)在155~400μmolTE/g,成功的表明了能够很好的防止过氧自由基、羟自由基、单线态氧、超氧阴离子、过氧亚硝基对眼部的氧化损伤,抑制过量自由基的形成,提高改善视力,缓解视疲劳。The free radical scavenging ability of the inventive health food examples 1 to 6 was evaluated and tested by the technique, and the ORAC value (peroxy radical scavenging ability) was 950 to 1730 μmol TE/g, and the HORAC value (hydroxy radical scavenging ability) was used. At 2260~6090μmol TE/g, SORAC value (superoxide anion scavenging ability) is 1405~8840 μmol TE/g, SOAC value (single-line oxygen scavenging capacity) is 4410~12040μmol TE/g, NORAC value (peroxynitrite removal ability) ) 155 ~ 400μmol TE / g, successfully showed that it can prevent oxidative damage to the eye by peroxy radical, hydroxyl radical, singlet oxygen, superoxide anion, peroxynitrite, inhibit excessive free radicals The formation of improved visual acuity and relief of visual fatigue.
当然本发明尚有多种具体的实施方式,在此就不一一列举。凡采用等同替换或者等效变换而形成的所有技术方案,均落在本发明要求保护的范围之内。Of course, there are many specific embodiments of the present invention, which are not enumerated here. All technical solutions formed by equivalent replacement or equivalent transformation are within the scope of the claimed invention.
Claims (10)
- 一种有助于缓解视疲劳保健食品,其特征在于,所述食品主要由以下成分按质量百分比组成:越橘提取物5%~60%,叶黄素0.5%~35%,绿茶提取物1%~40%,芦荟凝胶冻干粉200:1 0.1%~30%,姜黄提取物0.2%~20%,枸杞提取物0.5%~35%,其中,所述越橘提取物中原花青素含量≥20%,所述绿茶提取物中茶多酚含量≥90%,所述姜黄提取物中姜黄素含量≥90%,所述枸杞提取物中枸杞多糖含量≥25%。A health food for helping to alleviate visual fatigue, characterized in that the food is mainly composed of the following components by mass percentage: bilberry extract 5% to 60%, lutein 0.5% to 35%, green tea extract 1 %~40%, aloe vera gel lyophilized powder 200:1 0.1%~30%, turmeric extract 0.2%~20%, 枸杞 extract 0.5%~35%, wherein the biloba extract has proanthocyanidin content≥ 20%, the tea polyphenol content in the green tea extract is ≥90%, the curcumin content in the turmeric extract is ≥90%, and the cockroach polysaccharide content in the cockroach extract is ≥25%.
- 如权利要求1所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品中还包括微晶纤维素10%~50%,硬脂酸镁5%~30%,二氧化硅5%~30%。The health food for assisting relief of visual fatigue according to claim 1, wherein the food further comprises 10% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and dioxide. Silicon 5% to 30%.
- 如权利要求1所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品主要由以下成分按质量百分比组成:越橘提取物10%~50%,叶黄素1%~30%,绿茶提取物1%~30%,芦荟凝胶冻干粉200:1 0.5%~20%,姜黄提取物1%~20%,枸杞提取物0.5%~20%。The health food for assisting relief of visual fatigue according to claim 1, wherein the food is mainly composed of the following components in a mass percentage: 10% to 50% of the cranberry extract, and 1% of the lutein. 30%, green tea extract 1% to 30%, aloe vera gel lyophilized powder 200:1 0.5% to 20%, turmeric extract 1% to 20%, and medlar extract 0.5% to 20%.
- 如权利要求3所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品主要由以下成分按质量百分比组成:越橘提取物10%~30%,叶黄素1%~20%,绿茶提取物1%~20%,芦荟凝胶冻干粉200:1 0.8%~15%,姜黄提取物2%~20%,枸杞提取物0.6%~15%。A health food for helping relieve eye fatigue according to claim 3, wherein the food is mainly composed of the following components in a mass percentage: 10% to 30% of the cranberry extract, and 1% of the lutein. 20%, green tea extract 1% to 20%, aloe vera gel lyophilized powder 200:1 0.8% to 15%, turmeric extract 2% to 20%, and alfalfa extract 0.6% to 15%.
- 如权利要求4所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品主要由以下成分按质量百分比组成:越橘提取物11%~20%,叶黄素1%~10%,绿茶提取物1%~15%,芦荟凝胶冻干粉200:1 1%~13%,姜黄提取物2%~10%,枸杞提取物0.7%~10%。The health food for assisting relief of visual fatigue according to claim 4, wherein the food is mainly composed of the following components in mass percentage: 11% to 20% of cranberry extract, and 1% of lutein. 10%, green tea extract 1% ~ 15%, aloe vera gel lyophilized powder 200:1 1% ~ 13%, turmeric extract 2% ~ 10%, medlar extract 0.7% ~ 10%.
- 如权利要求2所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品中还包括微晶纤维素10%~45%,硬脂酸镁5%~20%,二氧化硅5%~25%。The health food for assisting relief of visual fatigue according to claim 2, wherein the food further comprises 10% to 45% of microcrystalline cellulose, 5% to 20% of magnesium stearate, and dioxide. Silicon 5% to 25%.
- 如权利要求6所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品中还包括微晶纤维素11%~50%,硬脂酸镁5%~30%,二氧化硅10%~25%。The health food for assisting relief of visual fatigue according to claim 6, wherein the food further comprises 11% to 50% of microcrystalline cellulose, 5% to 30% of magnesium stearate, and dioxide. Silicon is 10% to 25%.
- 如权利要求7所述的一种有助于缓解视疲劳保健食品,其特征在于:所述食品中还包括微晶纤维素12%~45%,硬脂酸镁5%~15%,二氧化硅15%~25%。The health food for assisting relief of visual fatigue according to claim 7, wherein the food further comprises 12% to 45% of microcrystalline cellulose, 5% to 15% of magnesium stearate, and dioxide. Silicon is 15% to 25%.
- 如权利要求1所述的一种有助于缓解视疲劳保健食品的应用,其特征在于:所述食品用于避免过氧自由基、羟自由基、超氧阴离子、单线态氧、过氧亚硝酸基对眼部的氧化损坏。The use of a food for helping to alleviate visual fatigue according to claim 1, characterized in that the food is used for avoiding peroxy radicals, hydroxyl radicals, superoxide anions, singlet oxygen, peroxygen Nitric acid damage to the eye.
- 如权利要求1所述的一种全面抗氧化保健食品的制备方法,其特征在于:包括如下步骤,The method for preparing a comprehensive antioxidant health food according to claim 1, comprising the steps of:S1、原料准备,按质量百分比称取原料:越橘提取物5%~60%,叶黄素0.5%~35%,绿茶提取物1%~40%,芦荟凝胶冻干粉200:1 0.1%~30%,姜黄提取物0.2%~20%,枸杞提取物0.5%~35%,其中,所述越橘提取物中原花青素含量≥20%,所述绿茶提取物中茶多酚含量≥90%,所述姜黄提取物中姜黄素含量≥90%,所述枸杞提取物中枸杞多糖含量≥25%;S1, raw material preparation, weigh the raw materials by mass percentage: bilberry extract 5% ~ 60%, lutein 0.5% ~ 35%, green tea extract 1% ~ 40%, aloe vera gel lyophilized powder 200: 1 0.1 %~30%, turmeric extract 0.2%~20%, 枸杞 extract 0.5%~35%, wherein the content of proanthocyanidin in the cranberry extract is ≥20%, and the content of tea polyphenol in the green tea extract is ≥90 %, the curcumin content in the turmeric extract is ≥90%, and the glutinous polysaccharide content in the cockroach extract is ≥25%;S2、筛选,将准备好的原料并经过70-90目筛进行筛选,选出粒度均匀的原料待用;S2, screening, the prepared raw materials are screened through a 70-90 mesh sieve, and the raw materials with uniform particle size are selected for use;S3、混合,将过筛后的原料按照等量递增的方法混合均匀;S3, mixing, mixing the sieved raw materials in an equal amount of increasing manner;S4、辅料添加,在S3中加入辅料进行再次混合,制粒,干燥,制备成所需的胶囊剂型或片剂,所述辅料还包括微晶纤维素10%~50%,硬脂酸镁5%~30%,二氧化硅5%~30%。S4, adding auxiliary materials, adding auxiliary materials in S3 for remixing, granulating and drying to prepare a desired capsule dosage form or tablet, the auxiliary material further comprising microcrystalline cellulose 10% to 50%, magnesium stearate 5 % to 30%, and 5% to 30% of silica.
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EP4133950A4 (en) * | 2020-04-10 | 2023-10-25 | Shanghai Lytone Biochemicals, Ltd. | Edible composition for relieving asthenopia |
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CN104000201A (en) * | 2014-06-17 | 2014-08-27 | 史克勇 | Heath-care food capable of relieving visual fatigue |
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CN101474311A (en) * | 2009-01-22 | 2009-07-08 | 哈尔滨金道堂生物科技有限公司 | Soft capsule for alleviating eyestrain and preparation method thereof |
CN102552549B (en) * | 2011-12-19 | 2014-01-29 | 北京康比特体育科技股份有限公司 | Composition for improving visual fatigue and preparation method and application thereof |
CN104957616A (en) * | 2015-06-30 | 2015-10-07 | 湖南炎帝生物工程有限公司 | Health-care food having function of relieving visual fatigue |
CN105878573A (en) * | 2016-05-20 | 2016-08-24 | 王义明 | Composition for relieving visual fatigue |
CN106038872A (en) * | 2016-06-24 | 2016-10-26 | 湖北丽生堂生物科技有限公司 | Composition with function of alleviating asthenopia |
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CN101590149A (en) * | 2008-05-27 | 2009-12-02 | 北京因科瑞斯医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof with asthenopia releasing function |
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