WO2019100450A1 - Système d'endoscope multifonctionnel - Google Patents

Système d'endoscope multifonctionnel Download PDF

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Publication number
WO2019100450A1
WO2019100450A1 PCT/CN2017/115200 CN2017115200W WO2019100450A1 WO 2019100450 A1 WO2019100450 A1 WO 2019100450A1 CN 2017115200 W CN2017115200 W CN 2017115200W WO 2019100450 A1 WO2019100450 A1 WO 2019100450A1
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module
imaging
light source
image
endoscope
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PCT/CN2017/115200
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English (en)
Chinese (zh)
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程震
刘弘光
索永宽
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东北大学
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Publication of WO2019100450A1 publication Critical patent/WO2019100450A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A61B1/053—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion being detachable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres

Definitions

  • the invention belongs to the field of medical and industrial testing equipment and relates to a multifunctional endoscope system.
  • the endoscope detection system integrates many disciplines such as optics, imaging, and ergonomics. Since the beginning of the invention, medical endoscopes provide a reliable image basis for clinical diagnosis that is difficult to provide in vitro diagnosis, such as digestive tract and pulse. Solutions for the diagnosis and treatment of various diseases such as tube systems, ENT, nervous system and celiac disease.
  • Traditional endoscopes are mainly divided into fiberscopes and hardscopes. According to the difference of the imaging module in the distal end and the proximal end of the endoscope scope, the endoscopes currently used clinically can be further divided into an optical endoscope and an electronic endoscope.
  • the fiber mirror transmits images through the optical fiber, and the fiber processing process determines that the number of fibers in the unit cross-sectional area is limited (tens of thousands to hundreds of thousands), and the pixels of the imaging module in the camera can reach tens of millions.
  • the fiber fabrication process limits the image resolution of the fiberscope.
  • electronic endoscopes solved the problem of limited resolution of fiberscope imaging.
  • the imaging module is implemented in the millimeter level, it can be placed at the distal end of the endoscope, and then the image signal is transmitted through the electrical signal line, and the image resolution of the endoscope can be improved without using the optical fiber to conduct the image. Therefore, electronic mirrors are gradually replacing fiberscopes.
  • the resolution of the hard mirror imaging is not lost, and the imaging module is usually placed at the proximal end of the hard mirror without being limited by the size. It does not affect the resolution of endoscopic imaging.
  • Olympus's two-color narrow-bandwidth endoscope defines light of different wavelengths, leaving only red, green, and blue narrow-band light waves of 605nm, 540nm, and 415nm wavelengths.
  • the depth of narrow-band light waves penetrating the gastrointestinal mucosa is different, the blue band (415nm) penetrates shallowly, and the red band (605nm) can Deep submucosal layer, used to display submucosal vascular network, green band (540nm) can better display the middle layer of blood vessels.
  • endoscopes Despite the rapid replacement of endoscopic techniques, the function of endoscopes is currently limited to the anatomical imaging of tissues, and the imaging of endoscopes is limited to the observation of glare. Functional imaging signals such as fluorescence are typically several orders of magnitude slower than illumination sources. There is currently no effective means for functional imaging of microscopic tissues. For example, fluorescence imaging has proven to be an irreplaceable value and significance in both clinical pathology and basic medical research, and is an important and active frontier of molecular imaging.
  • near-infrared fluorescence imaging has been proved to have many characteristics such as small interference from background light, strong penetrating ability, high resolution and signal stability, especially in the short-wave near-infrared wavelength range (900-1700 nm) compared to visible spectrum.
  • range fluorescence is more pronounced.
  • the functional imaging method of fluorescence endoscope is difficult to apply and popularize in clinical practice, and its root cause is its low imaging sensitivity and imaging quality lacking reference value.
  • the present invention provides a multifunctional endoscope system that separates an endoscope scope from an imaging module, and the multifunctional endoscope system can break through the outer dimensions and the number of the imaging module itself.
  • Restrictions such as fluorescence imaging such as large size and weight of the imaging module, can be smoothly applied to an endoscope system, and can provide functional imaging such as fluorescence imaging with high sensitivity and multi-wavelength selection.
  • the main technical solutions adopted by the present invention include:
  • the invention provides a multifunctional endoscope system, comprising an endoscopic probe module for realizing endoscopic, a light source module, an imaging module, and an image processing and display module, wherein the light source module is used for an endoscope probe module Providing different light sources, the imaging module is configured to receive different image signals and form image signals into various images, and the image processing and display module is configured to process and display images transmitted by the imaging module;
  • the emitted light generated by the light source module is transmitted to the light source exit port of the endoscope probe module through the light source fiber bundle, and different emitted light illuminates the object to be tested, and the fluorescent signal generated by the object to be measured is scattered, reflected or excited to form various images.
  • a signal the image signal is transmitted to the imaging module through the image fiber bundle;
  • the light source module is provided with a light source output interface, and the input end of the light source fiber bundle is detachably connected to the light source output interface of the light source module,
  • An imaging input interface is disposed on the imaging module, and an output end of the imaging fiber bundle is detachably connected to the imaging input interface of the imaging module.
  • the light source output interface of the light source module has one or more
  • the light source bundle has one or more strips
  • the image bundle has one or more strips
  • the image input interface of the imaging module has one or more.
  • the light source fiber bundle has one or more strips
  • the light source module is configured to provide different light source devices, each light source device having one or more light source output interfaces, one light source output interface and one light source fiber bundle input. End connection; when a light source device is only connected to one endoscopic probe module, only one light source is provided for the endoscope probe module; when multiple light source devices are connected to the same endoscope probe module, the same An endoscopic probe module provides different kinds of light sources; when one light source device is connected to a plurality of endoscopic probe modules, a plurality of endoscope probe modules are provided with the same kind of light source;
  • the imaging fiber bundle has one or more strips, and the imaging module is configured to provide different imaging devices, each imaging device having one or more imaging input interfaces, a imaging input interface and an imaging fiber bundle
  • the output is connected; when an imaging device is only connected to one endoscopic probe module, the imaging device receives only image signals from the endoscopic probe module and forms various images; when multiple imaging devices are identical
  • a plurality of imaging devices simultaneously receive image signals from the same endoscopic probe module and form various images; when an imaging device is connected to a plurality of endoscopic probe modules, this The imaging device simultaneously receives various image signals from different endoscopic probe modules and forms them into various images.
  • the light source module comprises an illumination source device, and/or an excitation source device, and/or a treatment source device.
  • the objective end of the endoscopic probe module is provided with a microscope objective for microscopic imaging of the object to be tested, and/or
  • An objective lens end of the endoscopic probe module is provided with an electronic imaging module, the electronic imaging module includes an objective lens and an image acquisition processing module connected to the objective lens, and the image acquisition processing module passes through the data line and the image processing and display module Electrical connection.
  • the multifunctional endoscope system includes a spectroscopic device that separates images of different bands; and/or
  • the multifunctional endoscope system includes a lens group and a filter switching module coupled to the lens group, the filter switching module for providing a filter of different spectra for the imaging module; and/or
  • the multifunctional endoscope system includes an achromatic lens.
  • the spectroscopic device is mounted in the imaging module, connected to the imaging module to form an integral structure, or the spectroscopic device is separately disposed between the imaging module and the endoscopic probe module and connected to the imaging module; /or
  • the lens group and the filter switching module are both mounted in the imaging module, and are connected to the imaging module to form an integral structure, or the lens group and the filter switching module are separately disposed on the imaging module and the endoscope probe module. Between and connected to the imaging module; and/or
  • the achromatic lens is mounted in the imaging module, and is connected to the imaging module to form an integral structure, or the achromatic lens is separately disposed between the imaging module and the endoscope probe module, and is connected to the imaging module.
  • the imaging module is an imaging device switching module for providing different imaging devices, the imaging device switching module being coupled to the filter switching module and used in conjunction.
  • the imaging module comprises a visible light imaging device, and/or a near infrared imaging device.
  • the image processing and display module includes an image overlay processing unit, a brightness adjustment unit, a near-infrared image addition pseudo color processing unit, and a display unit.
  • the multifunctional endoscope system includes an endoscope body on which a catheter is disposed, and the endoscope body is connected to an endoscope probe of the endoscopic probe module through a catheter.
  • the plurality of imaging fiber bundles and the plurality of light source fiber bundles are disposed in the catheter, and the endoscopic instrument channel and the gas channel are disposed in the catheter.
  • the endoscope and the imaging module of the multifunctional endoscope system of the present invention form a separate structure, and the output end of the image fiber bundle is connected to the image input interface of the image capturing module to form a connection between the endoscope and the image capturing module. Breaking through the limitation of the size and quantity of the existing imaging device (imaging module), the size of the imaging module no longer restricts the development of the multifunctional endoscope, and lays a foundation for the design of the multi-imaging module endoscope system. .
  • the fluorescence imaging device with large volume and weight of the imaging module can be smoothly applied to the endoscope or the fiberscope system, and provides functional imaging such as high-sensitivity, multi-wavelength selective fluorescence imaging, and greatly accelerates the fluorescence endoscope.
  • functional imaging such as high-sensitivity, multi-wavelength selective fluorescence imaging, and greatly accelerates the fluorescence endoscope.
  • FIG. 1 is a schematic structural diagram of a multifunctional endoscope system according to an embodiment of the present invention.
  • the present invention provides a multifunctional endoscope system including an endoscopic probe module 1 for implementing endoscopic, an endoscope body 2, a light source module 3, a spectroscopic device, and a filter combined lens.
  • the endoscope body 2 is provided with a catheter, and the endoscope body 2 is connected to the endoscope probe of the endoscope probe module 1 through a catheter.
  • the catheter is provided with one or more light source fiber bundles 6 and one or more imaging fibers. Bunch 7.
  • the emitted light generated by the light source module 3 is transmitted to the endoscope through the light source bundle 6
  • the light source exit port of the mirror probe module 1 the different emitted light illuminates the object to be tested, and various image signals formed by the scattered, reflected or excited fluorescent signals of the sample to be detected are transmitted to the imaging module 4 through the image fiber bundle 7 for imaging.
  • the module 4 can receive different image signals and form the image signals into various images, and the image processing and display module 5 processes and displays the various images transmitted by the imaging module 4.
  • the light source module 3 is used to provide different light sources for the endoscope probe module 1.
  • the light source module 3 may be an illumination light source device, may be an excitation light source device, may be a therapeutic light source device, or may be two of the above or A combination of two or more light source modules.
  • a single light source module 3 is selected, a plurality of different light source devices belonging to the same type of light source module 3 can be selected; when the light source module 3 of the above combination is selected, a plurality of the light source modules 3 can be selected. Different light source devices.
  • Different types of light generated by the light source module 3 for example, illumination light, excitation light, therapeutic light, and white LED illumination light, etc.
  • the light source fiber bundle 6 beam splitting fiber
  • the number of light source devices at the light source module 3 may be one or more.
  • Each light source device is provided with one or more light source output interfaces, and one light source output interface is detachably connected to the input end of one light source fiber bundle 6 (ie, the light source device is formed in a separate connection with the endoscope main body).
  • the light source device is formed in a separate connection with the endoscope main body.
  • a light source device is only connected to one endoscope, only one light source is provided for the endoscope; when multiple light source devices are connected to the same endoscope, different kinds of light sources are provided for the same endoscope. .
  • the same kind of light source is provided for a plurality of endoscopes.
  • the objective lens end of the endoscopic probe module 1 can be separately provided with a microscope objective lens, and the image signal collected by the microscope objective lens is transmitted to the imaging module 4 through the image fiber bundle 7 for imaging, thereby realizing microscopic endoscope imaging of the object to be tested.
  • the objective lens end of the endoscopic probe module 1 can also be separately provided with an electronic imaging module.
  • the electronic imaging module includes an electronic objective lens and an image acquisition processing module connected to the electronic objective lens, and the image acquisition processing module directly passes through the data line and the image processing and display module. 5 electrical connection, the electronic imaging module directly transmits the collected image to the image processing and display module 5 for processing and display, Achieve high-resolution morphological imaging.
  • the length, material, soft and hard of the objective end of the endoscopic probe module 1 can be adjusted according to actual application requirements, and the handle portion can be provided with a mechanical device connected to the end of the objective lens for controlling the direction.
  • the objective lens end of the endoscopic probe module 1 can also be provided with a microscope objective and an electronic imaging module, wherein the microscope objective lens is transmitted to the imaging module 4 through the image fiber bundle 7 for imaging, and the electronic imaging module directly and image processing through the data line It is electrically connected to the display module 5, and the simultaneous use of the two can simultaneously obtain functional imaging and high-resolution morphological imaging.
  • the imaging module 4 may include one or more independent imaging devices, which may select a visible light imaging device that images the visible light band, such as an EMCCD camera that takes into consideration sensitivity and image acquisition speed;
  • a near-infrared imaging device that performs imaging in the near-infrared band for example, has a small-sized, high-sensitivity, high-resolution InGaAs camera; it is also possible to simultaneously select the above-described visible light imaging device and near-infrared imaging device.
  • a functional imaging apparatus such as fluorescence imaging
  • functional imaging such as fluorescence imaging with high sensitivity and multi-wavelength selection can be realized.
  • one or more imaging input interfaces are provided on each of the independent imaging devices, and the output of one imaging input interface and one imaging fiber bundle 7 is detachable. Connection (ie, the imaging device forms a separate connection with the endoscope body).
  • the imaging device receives only image signals from the endoscope and forms various images; when multiple imaging devices are connected to the same endoscope, The imaging device simultaneously receives the image signals from the same endoscope and forms them into various images.
  • multiple optical fibers can be used together with multiple imaging devices (multiple cameras) to acquire images of anatomical structures and different functions.
  • the imaging device When an imaging device is connected to a plurality of endoscopes, the imaging device simultaneously receives various image signals from different endoscopes and forms them into various images. Therefore, the present invention can realize flexible selection of imaging functions and functions suitable for a plurality of different application scenarios. image.
  • the imaging module 4 of the present invention can also be designed to integrate the above-mentioned plurality of different types of imaging devices into an integrated imaging device switching module, and can also realize functional imaging such as visible light imaging, near infrared imaging, or fluorescence imaging.
  • the imaging device switching module has a plurality of image input interfaces, and the image input interfaces can be connected to the output end of the image fiber bundle 7 of the same endoscope, or can be combined with the image fiber bundle 7 of the plurality of endoscopes.
  • the output connection can also realize flexible selection of imaging functions and functional imaging for a variety of different application scenarios, and occupy small space, low production cost, convenient carrying and flexible use.
  • the invention changes the integrated design of the traditional light source channel and the endoscope main body, optimizes the outer shape of the endoscope, and enables the endoscope user to further improve the ergonomic design of the endoscope.
  • Flexible endoscopic operation More importantly, the separation of the imaging module 4 of the present invention from the endoscope breaks through the limitation of the size and number of the imaging module 4 (imaging device) itself, so that the size of the imaging module 4 no longer restricts the multifunctional endoscope.
  • the development also laid the foundation for the design of multi-imaging module endoscope systems.
  • This design will enable the imaging module 4 to have a large volume and weight of fluorescence imaging and other devices that can be smoothly applied to the endoscope system, providing functional imaging with high sensitivity, multi-wavelength selective fluorescence imaging, and greatly accelerating the fluorescence endoscope.
  • the clinical application process and subsequent promotion of functional endoscopes will enable the imaging module 4 to have a large volume and weight of fluorescence imaging and other devices that can be smoothly applied to the endoscope system, providing functional imaging with high sensitivity, multi-wavelength selective fluorescence imaging, and greatly accelerating the fluorescence endoscope.
  • the light splitting device may be installed in the imaging module 4, connected to the imaging module 4 to form an integral structure, and may also be separately disposed between the imaging module 4 and the endoscopic probe module 1 and connected to the imaging module 4. .
  • the light splitting device can split the light into two paths of the visible light path and the near infrared light path, and the two light paths are respectively detected by the visible light imaging device and the near infrared imaging device.
  • the spectroscopic device here can preferably be a lower cost spectroscope, and the spectroscope is directly mounted in a mounting sleeve sleeved outside the image fiber bundle 7 during installation.
  • a spectroscopic device is disposed at the imaging module 4, which can separate images of different wavelength bands to realize separate imaging and real-time synchronous imaging of different wavelength images.
  • the filter combination lens group includes a lens group composed of a plurality of lenses 8 and a plurality of filters 9 connected to the lens group or a light-transmissive sheet switching module connected to the lens group. Its
  • the filter switching module provides the imaging module 4 with filters 9 of different spectra. When the imaging module 4 selects the imaging device switching module, the imaging device switching module is connected to the filter switching module and used in conjunction.
  • the entire filter combination lens group may be mounted together in the imaging module 4, connected to the imaging module 4 to form an integral structure, and may also be separately disposed between the imaging module 4 and the endoscopic probe module 1 and with the imaging module 4 connection.
  • the fluorescence imaging device When the fluorescence imaging device is selected, the adjustment of the fluorescence imaging wavelength range, image size, and magnification is achieved by the filter combination lens group. Further, through the selection and switching of the fluorescence imaging device, visible (400-700 nm), near-infrared region (700-900 nm), short-wave near-infrared (near-infrared region 900-1700 nm), and thermal imaging (greater than 3000 nm) can be realized. The acquisition of multiple wavelength images, and thus the selected image fiber bundle 7 should be matched to the fluorescence imaging device.
  • the achromatic lens may be mounted in the imaging module 4, connected to the imaging module 4 to form an integral structure, and may also be separately disposed between the imaging module 4 and the endoscopic probe module 1 and with the imaging module 4 connection.
  • the image can be adjusted by an achromatic lens.
  • the image processing and display module 5 includes an image superimposition processing unit, a brightness adjustment unit, a near-infrared image addition pseudo color processing unit, other image processing units, and a display unit.
  • the image superimposition processing unit adopts feature point detection to implement a splicing algorithm of overlapping images, and combines two images with overlapping regions into one wide viewing angle image.
  • the brightness adjustment unit can increase the brightness value of some pixels in the two images to make the image clear and distinct.
  • the near-infrared image adding pseudo color processing unit can display the gray image as a custom pseudo color, further improving the image sharpness.
  • the display unit can select a display screen with a simple structure and low cost, and realize receiving and displaying the image processed by each of the image processing units.
  • the catheter on the endoscope body 2 of the present invention is provided with an endoscopic instrument channel 10 and a gas channel, which is compatible with the existing clinical device, and is convenient for the operator to realize the surgical operation such as pathological sampling through the instrument channel 10, and can realize the traditional Clinically used operations such as endoscopic imaging and endoscopic surgery can also provide functional imaging such as fluorescence imaging with high sensitivity and multi-wavelength selection.
  • the multifunctional endoscope system of the present invention can be designed as the following application examples:
  • the design can simultaneously use multiple imaging fiber bundles and corresponding illumination source fibers, and cooperate with multiple imaging cameras and different filters to achieve simultaneous acquisition of optical signals of various wavelengths.
  • Different biological tissues have different characteristic spectra, different absorption and scattering abilities for different wavelengths of light, and optical dyes with different optical and biological characteristics can be used to distinguish different tissues, such as distinguishing between pathological tissues and physiological tissues.
  • luminescent substances of various principles such as bioluminescent substances, chemiluminescent substances, electroluminescent substances, and the like, can be used in the medical field.
  • imaging images can be used simultaneously to achieve a combination of multiple functional imaging, such as optical imaging, near-infrared fluorescence imaging (300-800 nm), and near-infrared two-zone fluorescence imaging ( Synchronous implementation of 800-1700 nm).
  • multiple functional imaging such as optical imaging, near-infrared fluorescence imaging (300-800 nm), and near-infrared two-zone fluorescence imaging ( Synchronous implementation of 800-1700 nm).
  • a quartz fiber can be used as the imaging fiber.
  • the quartz fiber is easier to realize a smaller single fiber diameter than a normal glass fiber during processing, the number of fibers per unit cross-sectional area can be greatly increased (more than 20,000 per square millimeter). Fiber) to improve the resolution of imaging.
  • the cross-sectional area is 19.6 mm 2 .
  • Three imaging fiber bundles with a cross-sectional area of 2 mm 2 can be built in, and separate optical fibers are provided for each imaging fiber bundle, leaving enough space for the endoscopic instrument channel.
  • These mutually independent imaging fiber bundles can be respectively coupled to a specific functional imaging module to achieve multi-channel imaging of the endoscope.
  • These images can be displayed separately, in the form of picture-in-picture as needed, or as an image. Provide more comprehensive image information for users of endoscopes, providing a sufficient basis for endoscopic diagnosis and further treatment.
  • the image fiber imaging in this design is compatible with traditional electronic endoscopic imaging design, taking into account the functional imaging of fiberscopes and high-resolution imaging of electronic mirrors.
  • the large-field imaging is freely switched between the micro-functional imaging of the micro-fiberscope in this design, and the two can cooperate to achieve better imaging results.
  • an electronic lens is mounted on the objective end of the endoscope, and the resulting image is returned to the image processing and display device as an electrical signal.
  • the endoscope is equipped with one or more imaging fiber bundles of the design and corresponding end lenses, and the acquired image information is transmitted along the optical fiber to the corresponding imaging module in the form of optical signals.
  • the image formed by the imaging module is also transmitted to the image processing and display device. These images can be displayed separately or in the form of picture-in-picture as needed, or overlapped into an image display to provide more comprehensive image information for endoscopic users, for endoscopic diagnosis and further Treatment provides a sufficient basis.
  • Microscopic imaging of the region of interest in a common endoscopic image provides both macroscopic and microscopic morphological and functional imaging information for the diagnosis and treatment of the disease.
  • Monochrome imaging and mixed color narrow-band endoscopic imaging of multiple color illumination sources can be achieved by switching between one imaging fiber and a light source, or using two or more imaging fibers simultaneously.
  • Different tissues are distinguished according to the different degrees of absorption, scattering or reflection of different wavelengths of light by different tissues.
  • 3D endoscopic imaging requires two cameras to complete, and the use of endoscopes for 3D functional imaging is more challenging due to the size limitations of conventional endoscopic scopes.
  • two high-sensitivity cameras can be used to simultaneously image weak optical signals for 3D functional imaging of endoscopes, such as fluorescence imaging.
  • This design can be combined with existing hard and fiberscopes for 3D functional imaging and morphological imaging.
  • the therapeutic light can be introduced through the illumination source fiber, not only by light irradiation therapy, but also by the imaging fiber to monitor the irradiation position and evaluate the treatment effect.
  • the image from the fiberscope is introduced into different optical paths by means of a beam splitter, and is equipped with an imaging camera with high sensitivity to the corresponding wavelength.
  • the images of these cameras are integrated to enable simultaneous imaging in different bands. For example, using a 900 nm beam splitter to introduce light smaller than and greater than 900 nm into different cameras, simultaneous simultaneous imaging of visible and near-infrared fluorescence can be achieved.
  • Functional imaging such as fluorescence imaging can be successfully realized. Functional imaging can obtain pathological features that are not recognized by morphological imaging. Different types of pathological tissue can be used to distinguish tumors, inflammatory ulcers and other pathological and physiological tissues by differentially ingesting fluorescent substances or autofluorescence of different tissues. Screening of tumors; or combining imaging agents with targeted binding capabilities to achieve diagnosis and treatment of disease.
  • ergonomic design the imaging unit is separated from the handle, the design of the handle is no longer limited by the size of the imaging unit, and the illumination fiber design perpendicular to the endoscope body is changed, improving the operability of the endoscope .
  • the endoscope scope can be designed according to different application categories and diagnosis and treatment of different diseases, making the operator more comfortable and convenient in use.
  • the instrument channel can be compatible with existing clinical devices, including endoscopic instrument channels, gas channels, and the like.
  • the endoscope body in this design can be detached from the imaging device so that the endoscope body can be separately cleaned, sterilized, and replaced.
  • the imaging module of this design can include a variety of cameras. By switching the imaging device (such as different cameras such as EMCCD or InGaAs) and the adjustable filter combination, the difference between an endoscope body can be realized. Combination and multi-function imaging. According to the actual needs of the clinic It realizes separate imaging and simultaneous imaging of different wavelengths of light, and realizes the clinical application requirements for diagnosis of different diseases. Since the imaging module of the conventional endoscope is fixed to the main body of the endoscope, it has to be adjusted and replaced as a whole. The imaging module in this design can be adapted to a variety of endoscope body designs, and each endoscope body can also be adapted to a variety of different cameras, enabling flexible selection of imaging functions and application of a variety of different Functional imaging of clinical application scenarios.
  • the above advantages of the present invention can realize functional imaging of an endoscope, and promote preclinical development and clinical application and promotion of functional endoscopic imaging through multi-image fiber bundles, microfiber lenses, and electronic lens design. .

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  • Endoscopes (AREA)

Abstract

L'invention concerne un système d'endoscope multifonctionnel, comprenant un module de sonde d'endoscope (1), un module de source lumineuse (3), un module d'imagerie (4) et un module de traitement et d'affichage d'image (5), le module de source lumineuse (3) fournissant différentes sources lumineuses pour le module de sonde d'endoscope (1) ; le module d'imagerie (4) reçoit différents signaux d'image et forme ceux-ci en diverses images ; la lumière émise générée par le module de source lumineuse (3) est transmise à un port de sortie de source lumineuse du module de sonde d'endoscope (1) au moyen d'un faisceau de fibres optiques de source lumineuse (6) ; divers signaux d'image formés par différentes lumières émises irradiant un objet à détecter pour générer un signal fluorescent par diffusion, réflexion ou excitation sont transmis au module d'imagerie (4) au moyen d'un faisceau de fibres optiques de transmission d'image (7) ; une extrémité d'entrée du faisceau de fibres optiques de source lumineuse (6) est reliée à une interface de sortie de source lumineuse du module de source lumineuse (3) ; et une extrémité de sortie du faisceau de fibres optiques de transmission d'image (7) est reliée à une interface d'entrée de transmission d'image du module d'imagerie (4). Le système d'endoscope multifonctionnel peut franchir les limites des dimensions et du nombre de modules d'imagerie eux-mêmes, de sorte qu'un dispositif, tel qu'un dispositif d'imagerie par fluorescence, qui est grand à la fois en volume et en poids est appliqué à un système d'endoscope, et une imagerie fonctionnelle, telle qu'une imagerie par fluorescence, pourvue d'une sensibilité élevée et d'une sélection de multiples longueurs d'onde est fournie.
PCT/CN2017/115200 2017-11-27 2017-12-08 Système d'endoscope multifonctionnel WO2019100450A1 (fr)

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