WO2019088070A1 - Dispositif d'imagerie de fond d'œil de type à balayage - Google Patents

Dispositif d'imagerie de fond d'œil de type à balayage Download PDF

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Publication number
WO2019088070A1
WO2019088070A1 PCT/JP2018/040252 JP2018040252W WO2019088070A1 WO 2019088070 A1 WO2019088070 A1 WO 2019088070A1 JP 2018040252 W JP2018040252 W JP 2018040252W WO 2019088070 A1 WO2019088070 A1 WO 2019088070A1
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WO
WIPO (PCT)
Prior art keywords
light
optical system
fundus
scanning
light receiving
Prior art date
Application number
PCT/JP2018/040252
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English (en)
Japanese (ja)
Inventor
鈴木　孝佳
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興和株式会社
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Application filed by 興和株式会社 filed Critical 興和株式会社
Priority to JP2019550398A priority Critical patent/JPWO2019088070A1/ja
Publication of WO2019088070A1 publication Critical patent/WO2019088070A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1025—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography
    • A61B3/15—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing

Definitions

  • the present invention relates to a scanning fundus imaging apparatus that two-dimensionally scans laser light and emits light to the fundus, and receives reflected light from the fundus to capture the fundus.
  • a scanning fundus imaging apparatus which two-dimensionally scans laser light in the horizontal direction and the vertical direction, illuminates the fundus with the two-dimensional scanned laser light, and receives reflected light from the fundus to photograph the fundus.
  • laser light for illuminating the fundus is reflected by the optical path division mirror and scanned at high speed in the horizontal direction by the polygon mirror (rotational polygon mirror), and subsequently by the galvano mirror (oscillation mirror) Slow scan in the vertical direction and two-dimensional scan.
  • the two-dimensionally scanned laser light is projected onto the fundus of the eye to be examined through an objective lens to illuminate the fundus.
  • the laser beam projected onto the fundus is reflected by the fundus, travels in the same optical path in the reverse direction, is reverse scanned in the vertical and horizontal directions, is received by the light receiving optical system, and a fundus image is acquired (see Patent Document 1 below). 2).
  • Patent No. 3287698 Japanese Patent Application Laid-Open No. 7-171107
  • the amount of light that can be received tends to decrease significantly as the horizontal scanning angle moves away from the optical axis. This is because the rotation axis of the polygon mirror is located away from the mirror surface, and as the polygon mirror rotates, the mirror surface moves in the rotation direction. For example, when the radius of the inscribed circle of the polygon mirror is 24 mm and the rotation angle is ⁇ 11 degrees, the movement distance of the center position of the mirror surface is ⁇ 4.6 mm. If the size of the mirror surface is 11 mm, it is calculated that 40% of the mirror surface can not be used at the maximum scanning angle.
  • Patent Document 1 describes that a diaphragm that forms a separated aperture is disposed on the pupil of an eye to be examined.
  • this stop is a stereo imaging stop (two-hole stop) having two apertures decentered with respect to the optical axis, and does not reduce uneven light reception depending on the rotation angle of the polygon mirror.
  • Patent Document 2 describes that a diaphragm is disposed in the vicinity of the pupil conjugate, but this diaphragm is for shielding harmful reflected light from the objective lens and is not a slit aperture diaphragm but a polygon mirror scan. Uneven light amount due to
  • the present invention has been made in view of the above problems, and can reduce the degree to which the amount of light received by the light receiving optical system depends on the scanning angle in the scanning optical system, and can photograph the fundus with high image quality It is an object of the present invention to provide a scan type fundus imaging apparatus.
  • the present invention The spot-like illumination light is scanned by the scanning optical system and projected onto the fundus of the eye through the objective lens optical system, and the reflected light of the projected illumination light on the fundus of the eye is rescanned using the same scanning optical system
  • a scanning fundus imaging apparatus that guides a light receiving optical system and constructs a fundus image from information of a fundus scanning position and fundus reflected light intensity,
  • a light blocking member disposed in the vicinity of an anterior segment conjugate position of the light receiving optical system and blocking harmful reflected light from the lens surface of the objective lens optical system;
  • a slit aperture stop disposed in the vicinity of an anterior segment conjugate position of the light receiving optical system and having a slit aperture;
  • the slit aperture stop is characterized in that the received light beam passing through the light blocking member and the slit opening is limited so that the change in the amount of received light when the scanning angle changes is reduced.
  • a light blocking member for blocking harmful reflected light from the objective lens surface and a slit aperture stop provided with a slit aperture are disposed. Since this slit aperture stop limits the received light flux passing through the light shielding member and the slit opening so that the change in the amount of received light when the scanning angle changes is reduced, a fundus image with less unevenness in brightness is obtained It is possible to capture the fundus in high quality.
  • FIG. 2 is an optical diagram showing an optical configuration of the entire scanning fundus imaging apparatus. It is an optical diagram which shows the detail of the scanning optical system of FIG. It is an optical view which expands and shows the light reception optical system of FIG.
  • (A) is a perspective view which shows a slit aperture stop and a light-shielding member
  • (b) is the front view.
  • FIG. 6 is an explanatory view showing a state in which the amount of light received by the reflected light from the fundus changes in accordance with the rotation angle of the polygon mirror.
  • FIG. 6 is an explanatory view showing a state in which the amount of light received from the fundus when the slit aperture stop is not provided changes according to the rotation angle of the polygon mirror.
  • FIG. 1 is a view showing the overall configuration of a scanning fundus imaging apparatus according to this embodiment
  • FIG. 2 is a detailed view of a scanning optical system
  • FIG. 3 is an enlarged view of a light receiving optical system.
  • laser light from a laser light source 10 passes through a condenser lens 11 and enters a light emitting pinhole 12 disposed at a position conjugate to a fundus conjugate plane.
  • the laser light whose diameter is reduced by the light emitting pinhole 12 is collimated by the collimator lens 13 and is incident on the light path division mirror (pupil division mirror) 14.
  • a focusing optical system 1 for projecting the light emitted from the laser light source 10 onto the fundus 50b via the pupil 50a of the eye 50 as a spot-like illumination light, using the condenser lens 11, the light projection pinhole 12 and the collimator lens 13 Are configured.
  • the laser beam incident on the optical path splitting mirror 14 is reflected there, is incident on the horizontal scanning device 20 constituted of, for example, a polygon mirror (rotational polygon mirror), and is scanned at high speed in the horizontal direction (main scanning direction).
  • the laser beam scanned at high speed is incident on the vertical scanning device 23 constituted of, for example, a galvano mirror (oscillating mirror) via the scanning relay lenses 21 and 22, and is slowly scanned in the vertical direction (sub scanning direction) .
  • the scanning relay lens 21 is composed of compound lenses 21a and 21b
  • the scanning relay lens 22 is composed of compound lenses 22a and 22b.
  • the horizontal scanning device 20, the scanning relay lenses 21 and 22, and the vertical scanning device 23 constitute the scanning optical system 2, and the scanning optical system 2 further transmits illumination light to the horizontal scanning device 20 as shown in FIG. It has a lens 24 to be incident.
  • the horizontal scanning device 20 is a polygon mirror having six mirror surfaces 20b in the illustrated example, and rotates about a rotation axis 20a perpendicular to the paper surface to horizontally scan the laser light.
  • the vertical scanning device 23 vertically scans laser light with galvano mirrors which differ in scanning direction by 90 degrees.
  • the laser beam scanned in the horizontal and vertical directions by the scanning optical system 2 is incident on the objective lens optical system 3 composed of the first lens group 30 and the second lens group 31.
  • the laser light scanned two-dimensionally by the scanning devices 20 and 23 passes through the objective lens optical system 3 as illumination scanning light, enters the pupil 50a of the eye 50 to be examined, and is projected on the fundus 50b.
  • the fundus 50b is raster-scanned by laser light in the horizontal and vertical directions, and the fundus 50b in the scanning region is illuminated by the laser light.
  • the laser light projected onto the fundus 50 b is reflected by the fundus 50 b, and the reflected light travels in the opposite direction in the same optical path and passes through the objective lens optical system 3.
  • the objective lens optical system 3 is configured such that the fundus conjugate surface 32 exists between the first lens group 30 and the second lens group 31, and a fundus image is formed on the fundus conjugate surface 32. .
  • the laser light having passed through the objective lens optical system 3 is reversely scanned in the vertical and horizontal directions by the scanning optical system 2 and becomes a light beam having a thicker light beam than the light beam before entering the scanning optical system 2 to the optical path splitting mirror 14 It will be incident.
  • the optical path splitting mirror 14 is disposed with its center coinciding with the optical axis and passes reflected light from the outside of the mirror to the light receiving optical system 4, and thus splits the light path into a light projection optical path and a light receiving optical path.
  • the optical path on the side of the eye to be examined from the optical path splitting mirror 14 is an optical path common to the light projecting optical system 1 and the light receiving optical system 4.
  • the light receiving optical system 4 comprises a light receiving lens 40, a light blocking member 41, a light receiving pinhole 42, light receiving relay lenses 45 and 46, and a light receiving element 43, as shown in FIG.
  • the reflected light passes through the light receiving lens 40 and the light receiving pinhole 42, and is received by the light receiving element 43 through the light receiving relay lenses 45 and 46.
  • the light receiving pinhole 42 is disposed in the vicinity of a position conjugate to the fundus 50 b
  • the light blocking member 41 is disposed in the vicinity of a position conjugate to the anterior ocular segment 50 a of the eye to be examined, for example, a pupil or a lens.
  • the harmful reflection light from the surface is blocked to avoid the generation of a central spot image (false image).
  • the slit aperture stop 47 is disposed in the vicinity of a position conjugate with the anterior segment 50a of the subject eye.
  • the slit aperture stop 47 is disposed at the same position as the light shielding member 41, and as described later, in order to reduce the change in the amount of received light depending on the scanning angle of the horizontal scanning device (polygon mirror) 20, the light shielding member.
  • the light reception light beam passing through the outer periphery of 41 and passing through the opening 47 c of the slit aperture stop 47 and entering the light receiving element 43 is restricted.
  • the slit aperture stop 47 has a black film deposited in parallel with a width d1 on both sides of one transparent glass plate to form light shielding portions 47a and 47b. To be a transparent portion of width d2.
  • the light shielding parts 47a and 47b become slit edges, and the transparent part between them becomes the slit opening 47c, and a circular black film of radius r1 is vapor-deposited at the center of the slit opening 47c. 41 are formed.
  • the center 41 a of the light shielding member 41 coincides with the center of the slit opening 47 c, and the slit opening stop 47 is arranged such that the center 41 a of the light shielding member 41 coincides with the optical axis L of the light receiving optical system 4. .
  • the slit width d2 of the slit aperture stop 47 is larger than the diameter 2 ⁇ r1 of the light shielding member 41, the central part of the light beam 48 of the reflected light from the fundus is shielded by the light shielding member 41 and the remaining part is shielded by the light shielding member 41 It passes slit opening 47c without being done. Further, the light shielding portions 47a and 47b of the slit aperture stop 47 equally block both sides 48a and 48b of the light beam 48 passing through the slit opening 47c, and limit the received light beam 48.
  • the light receiving element 43 is formed of, for example, a photodiode, and sends luminance information of each point of the fundus 50 b raster-scanned to the image processing unit 44.
  • the image processing unit 44 constructs a fundus image from the scanning position of the fundus 50 b and the luminance information thereof.
  • the fundus image thus constructed is not shown, but may be stored in a storage device, displayed on a display, or printed by a printer.
  • a diopter adjustment mechanism for adjusting the diopter of the eye 50 to be examined is provided in each of the projection optical system 1 and the light receiving optical system 4.
  • the collimating lens 13 of the light projecting optical system 1 is a focus lens for adjusting the diopter
  • the light receiving lens 40 of the light receiving optical system 4 is a focus lens for adjusting the diopter
  • the diopter adjustment is performed by moving the light receiving lens 13 and the light receiving lens 40 by the same amount in conjunction with each other along the optical axis.
  • the laser light source 10 when photographing the fundus, the laser light source 10 is turned on.
  • the light from the laser light source 10 is divided in its optical path by the optical path dividing mirror 14 through the light projecting optical system 1 and is two-dimensionally scanned in the horizontal and vertical directions by the scanning optical system 2.
  • the two-dimensionally scanned laser light passes through the objective lens optical system 3 and the spot-like illumination light is projected onto the fundus 50 b of the eye 50.
  • the fundus 50 b of the eye 50 to be examined is raster scanned by laser light, and the reflected light from the fundus 50 b passes through the objective lens optical system 3, the scanning optical system 2, and the optical path dividing mirror 14 and enters the light receiving optical system 4. Much of the harmful reflection light from the objective lens surface is blocked by the optical path splitting mirror 14 and subsequently blocked by the light receiving pinhole 42 and the light shielding portion of the light shielding member 41, and generation of a central spot image on the photographed screen is avoided. .
  • the light receiving element 43 sends luminance information of each point of the fundus 50b raster-scanned to the image processing unit 44, and the image processing unit 44 constructs a fundus image from the scanning position of the fundus 50b and the luminance information, and a photographed image of the fundus I will provide a.
  • a polygon mirror is used as the horizontal scanning device 20 of the scanning optical system 2.
  • the polygon mirror will be described with the same reference numeral 20 attached.
  • the amount of light that can be received tends to decrease significantly as the horizontal scanning angle moves away from the optical axis. This state is illustrated in FIG.
  • the reflected light from the fundus 50 b which has passed through the objective lens optical system 3 is reversely scanned in the vertical direction by the vertical scanning device 23 of the scanning optical system 2 and is transmitted to the polygon mirror 20 through the scanning relay lenses 22 and 21. Incident and reverse scanned in the horizontal direction. Since each mirror surface of the polygon mirror 20 is at a position away from the rotation axis 20a, as described below, the polygon mirror 20 rotates and the light amount of the fundus reflected light incident on the mirror surface decreases.
  • the middle row in FIG. 5 shows the case where the rotation angle of the polygon mirror 20 is 0 degree, and the light flux 25 on the mirror surface 20b of the reflected light from the fundus is in the left-right direction as shown on the right (right Then, although all the light is incident on the mirror surface 20b in the vertical direction), a part of each is kicked in the vertical direction (right and left direction in the right figure).
  • the rotation angle of the polygon mirror 20 is 11 degrees
  • the right half (lower half in the right figure) of the light beam 25 at the mirror surface 20b does not enter the mirror surface 20b as shown in the upper stage.
  • FIG. 6 When the slit aperture stop 47 is not provided in the light receiving optical system 4, how much the reflected light from the fundus changes depending on the rotation angle of the polygon mirror 20 in the light receiving optical system 4 is illustrated in FIG. 6.
  • the light beam received behind the light shielding member 41 is illustrated in the range of the rotation angle of -11 ° to 11 ° of the polygon mirror 20, and the shaded portion 41 'is the light shielding member 41.
  • the other part is the amount of light received.
  • the amount of light received by the light blocking member 41 is about half kicked at a rotation angle of 11 ° (corresponding to a scan of 22 ° from the optical axis), and as shown by the dotted line, the peripheral part of the photographic screen is sharp It becomes dark.
  • the slit aperture stop 47 is provided at the same position as the light shielding member 41.
  • the slit aperture stop 47 blocks the left and right of the light beam 48 passing through the outer periphery of the light shielding member 41 and passing through the slit opening 47 c across the width d 1, and limits the light beam 48.
  • the amount of light received by the slit aperture stop 47 is illustrated by a solid line in FIG. 7 in the range of the rotation angle of ⁇ 11 ° to 11 ° of the polygon mirror 20 as in FIG.
  • the light reception amount at a rotation angle of 0 ° of the polygon mirror 20 is reduced to almost half compared to the case without the slit aperture stop, but the difference with the rotation angle ⁇ 11 ° is small. Reflected light from the fundus which is not largely dependent on the rotation angle of 20 can be received. Therefore, since the captured image becomes an image with a small difference in brightness between the center and the periphery, it is possible to obtain an image suitable for diagnosis.
  • the extending direction of the light shielding portions 47a and 47b which become the slit edges of the slit aperture stop 47 is parallel to the rotation axis 20a of the polygon mirror 20, it is possible to obtain the image aimed most efficiently.
  • the slit aperture stop 47 is not disposed at the same position as the light shielding member 41, but as shown in FIG. 8, the anterior eye is located on the most object eye side of the light receiving optical system 4, ie, the object eye side of the light receiving lens 40. It can also be arranged near a part conjugate position. In this case, the slit aperture stop 47 is manufactured without forming a light shielding member in the slit opening 47 c by the same method as described in FIG. 4B. Also in this embodiment, it is possible to obtain a photographed image suitable for diagnosis with a small difference in brightness between the center and the periphery.
  • the collimating lens 13 and the light receiving lens 40 as focusing lenses for adjusting the diopter are interlocked and moved along the optical axis by the same amount.
  • the light shielding member 41 is made continuously larger than that at the diopter of diopter 0 It is necessary.
  • the light blocking member 41 is continuously moved toward the light receiving pinhole 42 in the direction opposite to the moving direction of the light receiving lens 40, and the apparent light blocking size is continuously increased accordingly.
  • the slit aperture stop 47 is moved together with the light shielding member 41 to the light receiving pinhole 42 side.
  • the slit aperture stop 47 is moved to the light receiving pinhole 42 side together with the light blocking member 41, the amount of light passing through the slit aperture stop 47 increases, and the light receiving amount blocked by the light blocking member 41 can be compensated. It is possible to prevent it from
  • FIG. 10 illustrates an example of adjusting the diopter to -10 diopters, for example.
  • the slit aperture stop 47 and the light shielding member 41 are moved to the light receiving pinhole 42 side, and at the same time, the light receiving lens 40 is moved to the light receiving pinhole 42 in the opposite direction.
  • the light blocking member 41 does not move even if the light receiving lens 40 moves.
  • FIG. 11 shows the effective light receiving amount immediately after passing through the slit aperture stop 47 and the light blocking member 41.
  • the upper row shows the case before the slit aperture stop 47 and the light blocking member 41 move, and the middle row shows only the light blocking member 41.
  • the lower part shows the case where the slit aperture stop 47 and the light shielding member 41 are simultaneously moved.
  • a shaded circular portion indicated by the reference numeral 41 ' is a portion shielded by the light shielding member 41, and a portion corresponding to a white portion around the shaded portion is received by the light receiving element 43. It can be understood that as a whole, the photographed image is prevented from becoming dark.

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  • Life Sciences & Earth Sciences (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Selon la présente invention, une lumière d'éclairage de type projecteur est balayée par un système optique de balayage (2) et projetée à travers un système optique à objectif sur un fond d'œil (50) d'un œil à examiner. La lumière réfléchie, c'est-à-dire la lumière d'éclairage projetée réfléchie par le fond de l'œil, est balayée à nouveau à l'aide du même système optique de balayage, et devient incidente sur un système optique de réception de lumière (4). Un élément d'arrêt de la lumière (41), qui arrête la lumière réfléchie nocive, réfléchie par la surface de l'objectif, et un orifice d'ouverture en fente (47), qui est pourvu d'une section d'ouverture en fente, sont disposés à proximité d'une position conjuguée du segment antérieur de l'œil dans le système optique de réception de lumière. L'orifice d'ouverture en fente limite le flux lumineux de la lumière reçue qui traverse l'élément d'arrêt de la lumière et la section d'ouverture en fente, réduisant ainsi l'ampleur du changement de la quantité de lumière reçue lorsque l'angle de balayage change.
PCT/JP2018/040252 2017-10-31 2018-10-30 Dispositif d'imagerie de fond d'œil de type à balayage WO2019088070A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021256400A1 (fr) * 2020-06-18 2021-12-23 株式会社Ｑｄレーザ Dispositif d'imagerie de fond d'œil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6458237A (en) * 1987-08-31 1989-03-06 Kowa Co Fundoscopy
JPH07171107A (ja) * 1993-12-17 1995-07-11 Canon Inc 眼科装置
JP2016028687A (ja) * 2014-07-23 2016-03-03 株式会社ニデック 走査型レーザー検眼鏡

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6458237A (en) * 1987-08-31 1989-03-06 Kowa Co Fundoscopy
JPH07171107A (ja) * 1993-12-17 1995-07-11 Canon Inc 眼科装置
JP2016028687A (ja) * 2014-07-23 2016-03-03 株式会社ニデック 走査型レーザー検眼鏡

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021256400A1 (fr) * 2020-06-18 2021-12-23 株式会社Ｑｄレーザ Dispositif d'imagerie de fond d'œil
JP2022000142A (ja) * 2020-06-18 2022-01-04 株式会社Ｑｄレーザ 眼底撮影装置
JP7476857B2 (ja) 2020-06-18 2024-05-01 株式会社Ｑｄレーザ 眼底撮影装置

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