WO2019050340A3 - 아보카도 오일 분획을 유효성분으로 포함하는 난청의 예방 또는 치료용 약학적 조성물 - Google Patents

아보카도 오일 분획을 유효성분으로 포함하는 난청의 예방 또는 치료용 약학적 조성물

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Publication number
WO2019050340A3
WO2019050340A3 PCT/KR2018/010513 KR2018010513W WO2019050340A3 WO 2019050340 A3 WO2019050340 A3 WO 2019050340A3 KR 2018010513 W KR2018010513 W KR 2018010513W WO 2019050340 A3 WO2019050340 A3 WO 2019050340A3
Authority
WO
WIPO (PCT)
Prior art keywords
avocado oil
treatment
hearing loss
prevention
pharmaceutical composition
Prior art date
Application number
PCT/KR2018/010513
Other languages
English (en)
French (fr)
Other versions
WO2019050340A2 (ko
Inventor
홍빛나
정우재
이계완
이정숙
박유화
김도훈
Original Assignee
동국제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 동국제약 주식회사 filed Critical 동국제약 주식회사
Priority to JP2020514611A priority Critical patent/JP6802946B2/ja
Publication of WO2019050340A2 publication Critical patent/WO2019050340A2/ko
Publication of WO2019050340A3 publication Critical patent/WO2019050340A3/ko
Priority to US16/791,570 priority patent/US11273194B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

본 발명은 아보카도 오일 분획을 유효성분으로 포함하는 난청의 예방 또는 치료용 약학적 조성물에 관한 것이다. 구체적으로, 본 발명에 따른 아보카도 오일 분획은, 특히 아보카도 오일의 이소프로판올 분획은 제브라피쉬 모델에서 네오마이신에 의해 감소된 유모세포의 수를 유의적으로 증가시킴으로써, 상기 아보카도 오일의 이소프로판올 분획은 난청의 치료에 유용하게 사용될 수 있다.
PCT/KR2018/010513 2017-09-08 2018-09-07 아보카도 오일 분획을 유효성분으로 포함하는 난청의 예방 또는 치료용 약학적 조성물 WO2019050340A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020514611A JP6802946B2 (ja) 2017-09-08 2018-09-07 難聴の予防または処置のための活性成分としてアボカド油画分を含有する医薬組成物
US16/791,570 US11273194B2 (en) 2017-09-08 2020-02-14 Pharmaceutical composition containing avocado oil fraction as active ingredient for prevention or treatment of hearing loss

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0115414 2017-09-08
KR20170115414 2017-09-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/791,570 Continuation-In-Part US11273194B2 (en) 2017-09-08 2020-02-14 Pharmaceutical composition containing avocado oil fraction as active ingredient for prevention or treatment of hearing loss

Publications (2)

Publication Number Publication Date
WO2019050340A2 WO2019050340A2 (ko) 2019-03-14
WO2019050340A3 true WO2019050340A3 (ko) 2019-05-02

Family

ID=65635027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/010513 WO2019050340A2 (ko) 2017-09-08 2018-09-07 아보카도 오일 분획을 유효성분으로 포함하는 난청의 예방 또는 치료용 약학적 조성물

Country Status (4)

Country Link
US (1) US11273194B2 (ko)
JP (1) JP6802946B2 (ko)
KR (1) KR102099363B1 (ko)
WO (1) WO2019050340A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102151155B1 (ko) * 2019-12-30 2020-09-03 동국제약 주식회사 난청의 예방 또는 치료용 조성물
KR102151152B1 (ko) * 2019-12-30 2020-09-03 동국제약 주식회사 난청의 예방 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055657A1 (fr) * 1998-04-29 1999-11-04 Laboratoires Pharmascience Nouveaux composes extraits d'huile vegetale utilisables dans l'industrie pharmaceutique et cosmetique, notamment pour l'inhibition de la croissance cellulaire
US6552208B1 (en) * 1998-06-02 2003-04-22 Karlshamns Ab Fractionation process
JP2007535524A (ja) * 2004-04-30 2007-12-06 ラボラトワール エクスパンシアンス 免疫系不全に関連する疾患の処置および予防に用いられる、アボカドのペプチド抽出物を含んでなる薬剤
JP2011037738A (ja) * 2009-08-08 2011-02-24 Chube Univ 難聴又は耳鳴りの予防・治療剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1608407T3 (da) * 2003-03-20 2006-12-04 Pharmacia Corp Dispergébar formulering af et antiinflammatorisk middel
US9089576B2 (en) 2004-04-30 2015-07-28 Laboratoires Expanscience Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin
KR101025687B1 (ko) 2008-04-28 2011-03-30 손경수 검색엔진링크프로그램을 이용한 검색방법 및 이를 위한기록메체
KR100971374B1 (ko) 2008-05-15 2010-07-20 히어랩 (주) 황금 추출물을 포함하는 난청의 예방 또는 치료용 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055657A1 (fr) * 1998-04-29 1999-11-04 Laboratoires Pharmascience Nouveaux composes extraits d'huile vegetale utilisables dans l'industrie pharmaceutique et cosmetique, notamment pour l'inhibition de la croissance cellulaire
US6552208B1 (en) * 1998-06-02 2003-04-22 Karlshamns Ab Fractionation process
JP2007535524A (ja) * 2004-04-30 2007-12-06 ラボラトワール エクスパンシアンス 免疫系不全に関連する疾患の処置および予防に用いられる、アボカドのペプチド抽出物を含んでなる薬剤
JP2011037738A (ja) * 2009-08-08 2011-02-24 Chube Univ 難聴又は耳鳴りの予防・治療剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOZANO, Y.F. ET AL.: "Unsaponifiable Matter, Total Sterol and Tocopherol Contents of Avocado Oil Varieties", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 70, no. 6, 1 June 1993 (1993-06-01), pages 561 - 565, XP055598036, ISSN: 0003-021X, DOI: 10.1007/BF02545319 *

Also Published As

Publication number Publication date
WO2019050340A2 (ko) 2019-03-14
KR102099363B1 (ko) 2020-04-10
JP2020528926A (ja) 2020-10-01
US20200215142A1 (en) 2020-07-09
US11273194B2 (en) 2022-03-15
KR20190028345A (ko) 2019-03-18
JP6802946B2 (ja) 2020-12-23

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