WO2019035679A3 - 피나스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법 - Google Patents

피나스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법 Download PDF

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Publication number
WO2019035679A3
WO2019035679A3 PCT/KR2018/009440 KR2018009440W WO2019035679A3 WO 2019035679 A3 WO2019035679 A3 WO 2019035679A3 KR 2018009440 W KR2018009440 W KR 2018009440W WO 2019035679 A3 WO2019035679 A3 WO 2019035679A3
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WIPO (PCT)
Prior art keywords
microparticles
finasteride
present
including finasteride
patient
Prior art date
Application number
PCT/KR2018/009440
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English (en)
French (fr)
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WO2019035679A9 (ko
WO2019035679A2 (ko
Inventor
김주희
Original Assignee
(주)인벤티지랩
김주희
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180057092A external-priority patent/KR102031740B1/ko
Application filed by (주)인벤티지랩, 김주희 filed Critical (주)인벤티지랩
Priority to US16/639,810 priority Critical patent/US11344624B2/en
Priority to CN201880053414.7A priority patent/CN110996916A/zh
Priority to EP18846645.2A priority patent/EP3669864A4/en
Priority to JP2019542343A priority patent/JP6722828B2/ja
Publication of WO2019035679A2 publication Critical patent/WO2019035679A2/ko
Publication of WO2019035679A3 publication Critical patent/WO2019035679A3/ko
Publication of WO2019035679A9 publication Critical patent/WO2019035679A9/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 피나스테라이드 및 생분해성 고분자를 포함하는 마이크로 입자로, 상기 마이크로 입자는 구형의 생분해성 고분자 입자에 피나스테라이드 약물이 고르게 분포되어 있는 형태이며, 상기 마이크로 입자의 입자 평균 직경은 20 내지 70㎛인 피나스테라이드를 포함하는 마이크로 입자에 관한 것이다. 본 발명은 피나스테라이드를 포함하는 마이크로 입자를 투여함에 따라, 1개월 내지 3개월 동안 지속적으로 탈모 치료 효과를 유지할 수 있는 서방성 마이크로 입자 및 이의 제조 방법에 관한 것이며, 또한, 본 발명은 피나스테라이드를 포함하는 마이크로 입자를 주사를 통해 환자에게 투여하는 방식으로 이용하여, 경구형 제형과 달리, 환자가 직접 보관 및 취급을 하지 않아도 됨에 따라, 보관 및 취급의 용이하며, 1개월 내지 3개월의 기간 동안 장기간 약물 효과를 유지함과 동시에, 입자의 평균 직경을 일정한 마이크로 크기의 사이즈로 제조함에 따라, 환자에게 주사제로 투여 시의 이물감 및 통증을 감소시켜, 주사제로의 투여를 용이하게 할 수 있다.
PCT/KR2018/009440 2017-08-18 2018-08-17 피나스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법 WO2019035679A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US16/639,810 US11344624B2 (en) 2017-08-18 2018-08-17 Microparticles containing finasteride and preparation method thereof
CN201880053414.7A CN110996916A (zh) 2017-08-18 2018-08-17 包含非那斯特莱的微粒及其制备方法
EP18846645.2A EP3669864A4 (en) 2017-08-18 2018-08-17 MICROPARTICLE WITH FINASTERIDE AND METHOD OF MANUFACTURING THEREOF
JP2019542343A JP6722828B2 (ja) 2017-08-18 2018-08-17 フィナステリドを含むマイクロ粒子及びその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170104776 2017-08-18
KR10-2017-0104776 2017-08-18
KR1020180057092A KR102031740B1 (ko) 2017-08-18 2018-05-18 피나스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
KR10-2018-0057092 2018-05-18

Publications (3)

Publication Number Publication Date
WO2019035679A2 WO2019035679A2 (ko) 2019-02-21
WO2019035679A3 true WO2019035679A3 (ko) 2019-04-25
WO2019035679A9 WO2019035679A9 (ko) 2019-06-13

Family

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Application Number Title Priority Date Filing Date
PCT/KR2018/009440 WO2019035679A2 (ko) 2017-08-18 2018-08-17 피나스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법

Country Status (1)

Country Link
WO (1) WO2019035679A2 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1965839A (zh) * 2005-11-15 2007-05-23 上海医药工业研究院 非那雄胺及其类似物的注射用缓释微球、其制备方法及其应用
KR101012205B1 (ko) * 2002-12-06 2011-02-08 소켄 케미칼 앤드 엔지니어링 캄파니, 리미티드 마이크로채널을 사용하는 착색 구형입자의 제조방법 및이에 사용된 마이크로채널 타입 제조장치

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3162363T3 (pl) 2014-06-30 2020-06-15 Hanmi Pharm. Co., Ltd. Preparat złożony zawierający warstwę powłoki filmu zawierającą składnik aktywny

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101012205B1 (ko) * 2002-12-06 2011-02-08 소켄 케미칼 앤드 엔지니어링 캄파니, 리미티드 마이크로채널을 사용하는 착색 구형입자의 제조방법 및이에 사용된 마이크로채널 타입 제조장치
CN1965839A (zh) * 2005-11-15 2007-05-23 上海医药工业研究院 非那雄胺及其类似物的注射用缓释微球、其制备方法及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHMED, OSAMA AA ET AL.: "Finasteride-loaded Biodegradable Nanoparticles: Near-infrared Quantification of Plasma and Prostate Levels", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 32, no. 6, 1 February 2017 (2017-02-01), pages 1 - 11, XP055594955 *
KINOSHITA, KOJI ET AL.: "From Single Micropariicles to Microfluidic Emulsification: Fundamental Properties(solubility, density, phase separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres", PROCESSES, vol. 4, no. 49, 2016, pages 1 - 28, XP055594903 *
ROQUE, LUIS V. ET AL.: "Design of Finasteride-loaded Nanoparticles for Potential Treatmen of Alopecia", SKIN PHARMACOLOGY AND PHYSIOLOGY, vol. 30, 8 June 2017 (2017-06-08), pages 197 - 204, XP055594956 *

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Publication number Publication date
WO2019035679A9 (ko) 2019-06-13
WO2019035679A2 (ko) 2019-02-21

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