WO2019024112A1 - 一种钙基离子溶液炮制中药的方法及其应用 - Google Patents
一种钙基离子溶液炮制中药的方法及其应用 Download PDFInfo
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- WO2019024112A1 WO2019024112A1 PCT/CN2017/096095 CN2017096095W WO2019024112A1 WO 2019024112 A1 WO2019024112 A1 WO 2019024112A1 CN 2017096095 W CN2017096095 W CN 2017096095W WO 2019024112 A1 WO2019024112 A1 WO 2019024112A1
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- chinese medicine
- calcium
- traditional chinese
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- based ion
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Definitions
- the invention belongs to the field of Chinese medicine processing, and more particularly relates to a method for processing traditional Chinese medicine by using calcium-based ion solution and application thereof.
- Meridians are the channels through which blood is run in the human body, and all the internal organs, organs, pores, and tissues such as fur, muscles, and bones are closely linked to form a unified whole. Therefore, the meridians have a certain relationship in the physiological functions, pathological changes, symptom manifestations, and diagnostic basis of the human body. It is the main body of the meridian, also known as the meridian. There are mainly twelve acupoints of the meridians, Renmai and Dumai, also known as the "fourteen meridian points". Each meridian has a specific connection with the viscera. These yin and yang are connected to each other and become a relationship. The "acupoints" are the points on the meridians, which are the parts of the cross-over.
- human viscera has the characteristic of selective absorption of drug taste. It has important significance for guiding clinical medication. After oral administration of the drug into the digestive tract, it is also effective by transporting the meridian to the corresponding viscera.
- Traditional Chinese medicines have been orally or skin-coated. Due to their penetration and absorption rate, the effect of traditional Chinese medicine meridian coating has been unsatisfactory.
- Soaking is an important and important part of processing traditional Chinese medicine. Soaking before decoction of Chinese herbal medicine pieces is beneficial to the full dissolution of the active ingredients, shortening the boiling time, and avoiding excessive consumption of some active ingredients due to excessive boiling time.
- Most drugs should be soaked in cold water, pour the medicine into the pot and flatten it, then add room temperature water--room temperature water soak for 60 minutes, when the medicine is lightly pressed, the water is about 2 cm higher than the medicine plane.
- the principle of soaking in medicinal materials The summer temperature is high, soaking time should not be too long, so as to avoid spoilage, winter can be longer. It is especially important to note that soaking Chinese medicines must never be soaked in boiling water.
- soaking water generally selects a relatively simple composition of tap water or purified water, and almost no mineral-rich aqueous solution is selected.
- a first object of the present invention is to provide a method for processing a traditional Chinese medicine with a calcium-based ion solution.
- a second object of the present invention is to provide a calcium-based ion solution for the preparation of a traditional Chinese medicine.
- the traditional Chinese medicine obtained by the method is administered by transdermal meridian.
- a third object of the present invention is to provide a soaking liquid for processing Chinese medicine which improves the meridian permeability and absorption rate of a traditional Chinese medicine.
- a fourth object of the present invention is to provide an application of a soaking liquid for processing Chinese medicine in the preparation of a traditional Chinese medicine skin meridian administration coating agent.
- the present invention discloses the following technical solution: a method for processing a traditional Chinese medicine by using a calcium-based ion solution, characterized in that a calcium-based ion solution is immersed in a solution of a calcium-based ion solution + liquor, the calcium-based ion solution It refers to a solution containing a calcium ion mass percentage concentration of 0.3% to 10%, and the white wine is a white wine having a degree of between 35 and 75 degrees.
- the calcium-based ion solution is obtained by immersing the shell in a dilute hydrochloric acid solution
- the shell refers to oyster, clam shell, pearl, stone cassia, jellyfish, clam, clam, burly, car channel, purple One or several of shellfish, snail, snail, shrimp shell, and crab shell.
- the traditional Chinese medicine is for treating freckle, eye bags, skin whitening, hair loss prevention, hair removal, dandruff, gout, glaucoma, eczema, psoriasis, itching, arthritis and degenerative diseases, foot Department of dampness, athlete's foot, foot dredge meridians, female breast hyperplasia, stretch marks, pre-growth gland inflammation, skin cancer, hyperglycemia, hyperlipidemia, benign prostatic hyperplasia, urinary tract infection, chronic nephritis, proteinuria, uterine fibroids, lung Nodules, hepatic cysts, gallstones, fatty liver, neurasthenia, tumors, cervical spondylosis, neck and shoulder pain, muscle spasm, frozen shoulder, sports muscle injury, male sexual function, Parkinson's disease, cardiovascular and cerebrovascular Disease, trigeminal neuralgia, mastitis, herpes zoster sequelae - neuropathic pain, Alzheimer's
- the present invention discloses the following technical solution: the Chinese medicine obtained by the method of processing the traditional Chinese medicine by using the calcium-based ion solution is administered by transdermal meridian.
- the present invention discloses the following technical solution: a soaking liquid for processing a traditional Chinese medicine, wherein the soaking liquid is a solution of a calcium-based ion solution + liquor, and the calcium-based ion solution means A solution containing a calcium ion mass percentage concentration of 0.3% to 10%, the white wine being a white wine having a degree of between 35 and 75 degrees.
- the calcium-based ion solution is obtained by immersing the shell in a dilute hydrochloric acid solution
- the shell refers to oyster, clam shell, pearl, stone cassia, jellyfish, clam, clam, burly, car channel, purple One or several of shellfish, snail, snail, shrimp shell, and crab shell.
- the present invention discloses the following technical solution: the application of the infusion solution of the traditional Chinese medicine in the preparation of the traditional Chinese medicine prescription for the meridian administration of the skin.
- the traditional Chinese medicine is for treating hyperglycemia, hyperlipemia, benign prostatic hyperplasia, urinary tract infection, chronic nephritis, proteinuria, uterine fibroids, pulmonary nodules, hepatic cysts, gallstones, fatty liver, neurasthenia, Tumor, cervical spondylosis, neck and shoulder pain, muscle spasm, frozen shoulder, sports muscle injury, male sexual function, Parkinson's disease, cardiovascular and cerebrovascular disease, trigeminal neuralgia, mastitis, herpes zoster sequelae - nerve Chinese medicine for sexual pain, Alzheimer's disease, eye diseases, and wormwood extract for treating related diseases.
- the invention has the advantages that: the "calcium-based ion solution + liquor" soaking solution is used to soak the traditional Chinese medicine.
- the preparation has a better guiding effect on skin penetration, and proposes a new mode of administration and administration route, which solves the problem that the traditional Chinese medicine prescription cannot be administered through the skin to penetrate the meridian points.
- calcium-based ion solution + liquor to prepare Chinese medicine, it is possible to change the administration mode of some Chinese medicines (dose and medicine), and the therapeutic effect can be achieved by external application, avoiding the gastrointestinal irritation and liver and kidney damage of Chinese medicine. The effect of external treatment.
- Soaking the skin of the traditional Chinese medicine preparation with the solution of the technology can reduce or inhibit the neuropathic pain on the local peripheral nerve of the affected area, and can treat the symptoms such as nerve tingling in the human body.
- Soaking the preparation of traditional Chinese medicine with the solution of the technology can directly affect the absorption of the skin, and can change the mode of administration of some Chinese medicine (dose, medicine) through the digestive tract to avoid the stimulation of the gastrointestinal tract by the oral Chinese medicine.
- the method of extracting the preparation by using the technology solution can greatly improve the use efficiency of the medicine.
- the actual test production process confirmed that the original dose of one day (a prescription) can now be used for one course of treatment - that is, 15 days. It can improve the utilization rate of medicinal materials and has important significance for the protection and rational utilization of Chinese medicinal materials.
- Figure 1 shows the results of testing the ion content of the calcium-based ion solution obtained by extracting pearls.
- the calcium-based ion solution used in the present technology is an active organic hydrophilic ionic liquid extracted from shellfish, shrimp and crab shells, and the soaking container is a non-metal covered vessel.
- the calcium-based ion solution of the present technology is specified by using the calcium content in the liquid as a standard value for measuring the dilution concentration of the ionic liquid (the stock solution content is 20%).
- the specific gravity of wine and calcium-based ion stock solution is 0.92: 1.364/ml At the time, the calcium content is 20% (extreme value).
- the ion calcium content is 5%, and so on, or the desired diluted ionic liquid concentration can be measured by the specific gravity method.
- the liquor used in the present technology is a pure grain edible wine of 35 degrees or more sorghum and wheat fermented, preferably 60 degrees white spirit.
- the calcium-based ion solution is diluted to 0.3%-10% for use, and the ion calcium content threshold is also different for different diseases and uses.
- the traditional Chinese medicine taste should meet the meridians of the viscera, and it should conform to the clinical guidance of “Guijing”.
- the extracted preparation is sprayed on the corresponding acupuncture point (slightly tapping or massage to help absorb). It is recommended to take two times a day, each time. Excessive use can cause skin irritation. It will return to normal after two or three days of deactivation. If it is used excessively for a long time, it will cause calcification on the skin, and it will return to normal within two weeks after the withdrawal.
- the technology is mainly for the treatment of various diseases such as visceral inflammation, tumor, cardiovascular and cerebrovascular system, neuropathic pain, neck, shoulder, waist and leg diseases.
- the number of sample people is 10: divided into A and B groups. 5 people in each group.
- Sample preparation divided into A and B liquids: different soaking solutions are used, and other conditions are the same.
- a solution a preparation obtained by soaking Chinese herbal medicine in a solution composed of calcium-based ionic liquid + white wine.
- 4.B solution a preparation obtained after soaking Chinese herbal medicine in a single liquor solution.
- the calcium-based ion solution is composed of ions having Ca 2+ as a main element and Na + , Mg 2+ , K + , Cl - , Br, S, and the like. Human cells have Ca 2+ , Na + , K + , Cl - ion channels. When a certain threshold ion is accumulated outside the skin, it affects the ions in the cell membrane, accelerates ion exchange inside and outside the cell membrane, and promotes the penetration of the drug solution. For this reason, calcium-based ions have permeability to skin tissue.
- Calcium-based ion solution retains its own taste in addition to guiding skin penetration. Because it is an active hydrophilic ion extracted from shellfish, the mother is a shell, so it has the natural properties of shells. According to the "Compendium of Materia Medica” records: oysters [taste] salty, flat, slightly cold, non-toxic. [Indications] Resolving phlegm and softening, clearing away heat and dehumidification, stopping heart qi and spleen, sputum red and white turbidity, eliminating phlegm and agglomeration, dysentery tuberculosis. It has been used as a drug for softening and stasis in all prescriptions. (Different shells have different taste effects.)
- Liquor According to the “Chinese Medical Dictionary”: the wine can disperse cold stagnation, open the knot, eliminate the diet, dredge the meridians, reconcile the camp.
- Practiceal Pharmacology Dictionary records: wine is a blood circulation, help medicine to medicine.
- Calcium carbonate reacts with hydrochloric acid to form calcium chloride, carbon dioxide and water, which are converted from solid calcium carbonate to liquid calcium chloride solution.
- This solution was tested to contain the following components: Na + , Ca 2+ , Mg 2+ , K + , Cl - , Br, S, and protein).
- a variety of ionic solutions are naturally formed by the shell gene program, which we call "calcium-based ion solutions.”
- the calcium-based ion solution used in the present technology is a combination of organic matter and inorganic matter in the shellfish of the organism, and the effect is better than the compatibility of the ions alone.
- Shell smell classification (excerpted from "Compendium of Materia Medica”, [indications] see related text).
- Symptoms high blood sugar, spleen deficiency, wet and dampness, and kidney yin deficiency, accompanied by high cholesterol, constipation and other symptoms.
- Soaking solution preparation ratio liquor 750ml calcium-based ion stock solution (crab shell) 55ml.
- acupuncture points foot sputum yin and liver, Zhangmen point, foot Taiyin spleen, Sanyinjiao. Twice a day, about 2ml each time. Spray on the left and right acupuncture points separately, and massage for 3 minutes at the acupoints to help absorb.
- Symptoms Hyperlipidemia. Headache, dizziness, head swelling, numbness of fingers, troublesome chest tightness, dry stool.
- Soaking solution preparation ratio white wine 2000ml calcium-based ion stock solution (crab shell) 150ml.
- Kidney deficiency cold and heat, constipation, abdominal pain, constipation, rib pain, urinary flow, urgency, frequent urination and other symptoms.
- Soaking solution preparation ratio liquor 1500ml calcium-based ion stock solution (oyster) 150ml.
- Soaking solution preparation ratio white wine 2000ml calcium-based ion stock solution (screw) 150ml.
- acupuncture points foot Shaoyin kidney, air points. Two times a day, 2ml each time.
- Soaking solution preparation ratio 2500ml of liquor, calcium-based ion stock solution (oyster) 200ml.
- Symptoms "The pain will be repeated for a long time.” The hospital diagnosed a liver cyst enlargement.
- Soaking solution preparation ratio white wine 3000ml calcium-based ion stock solution (oyster) 300ml.
- Symptoms The hands are involuntarily shaking, so that they can not hold things, the upper limbs are stiff, the action is slow, the words are sluggish, and the expression is dull.
- the hospital neurology diagnosis is Parkinson's disease.
- Soaking solution preparation white wine 3000ml calcium-based ion stock solution ( ⁇ ) 200ml.
- Symptoms Insomnia, irritability, restlessness, shortness of breath, shortness of breath, and poor abdominal distension.
- Soaking solution preparation ratio liquor 1500ml calcium-based ion stock solution (pearl) 75ml.
- Symptoms dizziness, hand numbness, weak legs, occasional palpitation, excessive sweating, anorexia, and poor bowel movements. Diagnosis by the hospital neurology: arteriosclerosis, cerebral ischemia.
- Soaking solution preparation ratio white wine 700ml calcium-based ion stock solution (oyster) 50ml.
- Symptoms facial trigeminal neuralgia, paroxysmal, knife-like severe pain, once a day. Often sudden onset, suddenly stopped. Each time lasts 2-3 minutes. Diagnosed by the hospital: the first trigeminal neuralgia on the left side.
- Soaking solution preparation ratio liquor 1500ml calcium-based ion stock solution (crab shell) 120ml.
- A is a hole (spraying the affected area). Twice a day, about 1-2ml each time.
- Soaking solution preparation ratio white wine 700ml calcium-based ion stock solution (pearl) 20ml.
- acupuncture points the head and neck pass through the outer strange point, the sputum point, the silk bamboo point (the corner of the eyebrow), massage for three minutes. Apply liquid to the upper and lower eyelids and gently massage for two minutes.
- the preparation extracted with the solution of the technology is filled with a pressure-free spray bottle.
- the medication is simple, convenient, and easy to carry.
- a bottle of 30ml of liquid medicine can be used for one course of treatment, about 15 days.
- the medication process can be completed in 2-3 minutes per use.
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Abstract
Description
Claims (8)
- 一种钙基离子溶液炮制中药的方法,其特征在于,使用钙基离子溶液+白酒的溶液浸泡中药方剂,所述钙基离子溶液是指含有钙离子质量百分比浓度为0.3%-10%的溶液,所述白酒为度数在35-75度之间的白酒。
- 根据权利要求1所述的一种钙基离子溶液炮制中药的方法,其特征在于,所述钙基离子溶液由贝壳浸泡于稀盐酸溶液获得,所述贝壳是指牡蛎、蚌壳、珍珠、石决明、海蛤、文蛤、蛤蜊、魁蛤、车渠、紫贝、田螺、蜗螺、虾壳、蟹壳中的一种或几种。
- 根据权利要求1所述的一种钙基离子溶液炮制中药的方法,其特征在于,所述中药为治疗关于祛斑、祛眼袋、皮肤美白、防脱发生发液、去头屑护发水、痛风、白癜风、湿疹、牛皮癣、皮肤瘙痒、关节炎及退行性病变、足部祛湿、足癣、足部疏通经络、女性乳腺增生、妊娠纹、前例腺炎、皮肤癌、高血糖、高血脂、前列腺增生、尿路感染、慢性肾炎、蛋白尿、子宫肌瘤、肺结节、肝囊肿、胆结石、脂肪肝、神经衰弱、肿瘤、颈椎病、颈肩腰腿痛、肌肉痉挛、肩周炎、运动型肌肉损伤、男性性功能、帕金森氏症、心脑血管疾病、三叉神经痛、乳腺炎、带状疱疹后遗症-神经性疼痛、阿尔兹海默症、眼部疾患的中药,及艾草提取液治疗相关疾病的中药。
- 利用权利要求1—3任一所述钙基离子溶液炮制中药的方法炮制获得的中药的给药方式为经皮肤经络给药。
- 一种炮制中药的浸泡液,其特征在于,所述浸泡液为钙基离子溶液+白酒的溶液,所述钙基离子溶液是指含有钙离子质量百分比浓度为0.3%-10%的溶液,所述白酒为度数在35-75度之间的白酒。
- 根据权利要求5所述的一种炮制中药的浸泡液,其特征在于,所述钙基离子溶液由贝壳浸泡于稀盐酸溶液获得,所述贝壳是指牡蛎、蚌壳、珍珠、石决明、海蛤、文蛤、蛤蜊、魁蛤、车渠、紫贝、田螺、蜗螺、虾壳、蟹壳中的一种或几种。
- 权利要求5所述的炮制中药的浸泡液在制备中药方剂皮肤经络给药涂覆剂中的应用。
- 根据权利要求7所述的应用,其特征在于,所述中药为治疗关于高血糖、 高血脂、前列腺增生、尿路感染、慢性肾炎、蛋白尿、子宫肌瘤、肺结节、肝囊肿、胆结石、脂肪肝、神经衰弱、肿瘤、颈椎病、颈肩腰腿痛、肌肉痉挛、肩周炎、运动型肌肉损伤、男性性功能、帕金森氏症、心脑血管疾病、三叉神经痛、乳腺炎、带状疱疹后遗症-神经性疼痛、阿尔兹海默症、眼部疾患的中药,及艾草提取液治疗相关疾病的中药。
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JP2020528501A JP7356156B2 (ja) | 2017-08-04 | 2017-08-04 | カルシウム系イオン溶液を用いて漢方薬を炮製する方法 |
CN201780001034.4A CN109641021A (zh) | 2017-08-04 | 2017-08-04 | 一种钙基离子溶液炮制中药的方法及其应用 |
AU2017425813A AU2017425813A1 (en) | 2017-08-04 | 2017-08-04 | Method for processing traditional Chinese medicine using calcium-based ion solution and application thereof |
US16/634,908 US11219648B2 (en) | 2017-08-04 | 2017-08-04 | Method for processing traditional Chinese medicine using calcium-based ion solution and application thereof |
KR1020207005915A KR20200035436A (ko) | 2017-08-04 | 2017-08-04 | 칼슘계 이온 용액으로 중약을 제조하는 방법 및 이의 용도 |
PCT/CN2017/096095 WO2019024112A1 (zh) | 2017-08-04 | 2017-08-04 | 一种钙基离子溶液炮制中药的方法及其应用 |
EP17920065.4A EP3662918A4 (en) | 2017-08-04 | 2017-08-04 | METHOD FOR PROCESSING TRADITIONAL CHINESE MEDICINE USING CALCIUM-BASED ION SOLUTION AND APPLICATION THEREOF |
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CN109641021A (zh) | 2019-04-16 |
US20200316137A1 (en) | 2020-10-08 |
US11219648B2 (en) | 2022-01-11 |
EP3662918A1 (en) | 2020-06-10 |
AU2017425813A1 (en) | 2020-02-27 |
JP7356156B2 (ja) | 2023-10-04 |
JP2020529474A (ja) | 2020-10-08 |
EP3662918A4 (en) | 2021-03-24 |
KR20200035436A (ko) | 2020-04-03 |
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