WO2019015399A1 - Procédé et appareil de mesure de viscoélasticité d'un milieu - Google Patents

Procédé et appareil de mesure de viscoélasticité d'un milieu Download PDF

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Publication number
WO2019015399A1
WO2019015399A1 PCT/CN2018/088407 CN2018088407W WO2019015399A1 WO 2019015399 A1 WO2019015399 A1 WO 2019015399A1 CN 2018088407 W CN2018088407 W CN 2018088407W WO 2019015399 A1 WO2019015399 A1 WO 2019015399A1
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WIPO (PCT)
Prior art keywords
propagation mode
medium
echo signal
viscoelasticity
data set
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PCT/CN2018/088407
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English (en)
Chinese (zh)
Inventor
何琼
邵金华
孙锦
段后利
王强
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无锡海斯凯尔医学技术有限公司
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Publication of WO2019015399A1 publication Critical patent/WO2019015399A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/045—Analysing solids by imparting shocks to the workpiece and detecting the vibrations or the acoustic waves caused by the shocks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02827—Elastic parameters, strength or force

Definitions

  • the present invention relates to the field of measurement technology, and in particular to a method and apparatus for measuring the viscoelasticity of a medium.
  • the position time map is usually a straight twill pattern.
  • the slope is determined by the distance traveled by the vibration per unit time, that is, the speed at which the vibration propagates.
  • the speed of vibration propagation is related to the viscoelasticity of the medium. Therefore, when vibrating the medium, the viscoelasticity of the medium can be measured by measuring the propagation characteristics of the vibration.
  • the feature points need to be selected, and the feature points at different moments and different positions are linearly fitted, and the quantitative parameters of the dynamic ultrasonic viscoelastic imaging are obtained.
  • the feature points are determined by the displacement or strain of the medium when the vibration propagates in the medium.
  • motion estimation is required to obtain information such as displacement or strain of the medium, and then subsequent operations are performed.
  • this method has the problems of large computational complexity and complex feature point selection for motion estimation.
  • Embodiments of the present invention provide a method and apparatus for measuring the viscoelasticity of a medium.
  • the invention aims to solve the problem that the calculation amount required for motion estimation in the viscoelasticity measurement of the medium in the prior art is large, and the feature points are selected to be complicated.
  • This generalization is not a general comment, nor is it intended to identify key/critical constituent elements or to describe the scope of protection of these embodiments. Its sole purpose is to present some concepts in a simplified form as a prelude to the following detailed description.
  • an embodiment of the present invention provides a method for measuring a viscoelasticity of a medium, including:
  • the propagation mode is matched with a propagation mode sample of a medium sample of known viscoelastic information stored in the propagation mode data, and the viscoelasticity of the medium is determined.
  • the embodiment of the present invention provides a first optional implementation manner.
  • the vibration excitation is shear wave excitation
  • the detection wave echo signal is an ultrasonic echo signal.
  • an embodiment of the present invention provides a second optional embodiment, where the propagation mode data set includes propagation mode samples generated by at least one vibration excitation according to different media samples of different viscoelasticity.
  • the embodiment of the present invention provides a third optional implementation manner, which acquires a propagation mode of a detection wave echo signal, including:
  • the propagation mode is obtained based on the processed signal.
  • the embodiment of the present invention provides a fourth optional implementation manner.
  • the processing signal is a direction-filtered detection wave echo signal; or the processing signal is Fourier filtered detection echo signals.
  • the embodiment of the present invention provides a fifth optional implementation manner, which further includes:
  • Vibration excitation, detection of wave echo signals and viscoelasticity of the medium are stored in the propagation mode data set.
  • the embodiment of the present invention provides a sixth optional implementation manner:
  • the vibration excitation includes one of a continuous or pulsed mechanical vibration and an acoustic radiation force pulse;
  • the medium has a range of motion from 0.01 micron to 10 mm under vibration excitation;
  • the medium has a frequency of vibration from 20 Hz to 2500 Hz and a duration of 50 microseconds to 1 second.
  • the embodiment of the present invention provides a seventh optional implementation manner:
  • the pulse repetition frequency of the vibration excitation is 10 to 20,000 Hz;
  • the detected wave echo signal includes at least 100 consecutive frames of detected echo data.
  • an embodiment of the present invention provides a measuring device for viscoelasticity of a medium, comprising:
  • a processor configured to acquire a propagation mode of the detection wave echo signal acquired by the probe
  • a memory for storing a propagation mode data set, the propagation mode data set storing a propagation mode sample of the medium sample having known viscoelastic information
  • the processor is further configured to match the propagation mode with the propagation mode samples stored in the propagation mode data to determine the viscoelasticity of the medium.
  • the embodiment of the present invention provides a first optional implementation manner, including:
  • the probe is also used to obtain an ultrasonic echo signal of the medium excited by the shear wave;
  • the processor is further configured to acquire a propagation mode of the ultrasonic echo signal acquired by the probe;
  • the memory is also used to store propagation mode samples of the media samples of known viscoelastic information under shear wave excitation.
  • the embodiment of the present invention provides a second optional implementation manner, where the processor is further configured to:
  • the propagation mode data set is determined based on propagation mode samples generated by the plurality of medium samples of different viscoelasticity under at least one vibration excitation.
  • the embodiment of the present invention provides a third optional implementation manner, which further includes:
  • a filter for acquiring a processing signal for acquiring a processing signal, and the processing signal is a detection wave echo signal obtained by the filtered probe;
  • the processor is further configured to acquire a propagation mode according to the processed signal acquired by the filter.
  • the embodiment of the present invention provides a fourth optional implementation manner, where the processing signal is a direction-filtered detection wave echo signal; or the processing signal is Fourier filtering. After the detection wave echo signal.
  • the embodiment of the present invention provides a fifth optional implementation manner, where the processor is further configured to:
  • the vibration excitation, the detection of the wave echo signal and the viscoelasticity of the medium are stored in a propagation mode data set stored in the memory.
  • the measurement result of the medium viscoelasticity can be obtained without performing motion estimation and feature point selection, and the operation is performed.
  • the amount is greatly reduced and the measurement speed is significantly accelerated.
  • FIG. 1 is a flow chart of a method for measuring viscoelasticity of a medium according to an embodiment of the present invention
  • FIG. 2 is a flow chart of another method for measuring viscoelasticity of a medium disclosed in an embodiment of the present invention.
  • FIG. 3 is a flow chart of another method for measuring viscoelasticity of a medium disclosed in an embodiment of the present invention.
  • FIG. 4 is a flow chart of another method for measuring viscoelasticity of a medium disclosed in an embodiment of the present invention.
  • FIG. 5 is a schematic diagram of a measuring device for viscoelasticity of a medium according to an embodiment of the present invention.
  • FIG. 6 is a schematic diagram of another apparatus for measuring viscoelasticity of a medium disclosed in an embodiment of the present invention.
  • the embodiment of the invention discloses a method for measuring the viscoelasticity of a medium, as shown in FIG. 1 , which includes:
  • the propagation mode data set includes propagation mode samples generated by the plurality of media samples according to different viscoelasticity under at least one vibration excitation.
  • the vibration excitation includes but is not limited to mechanical vibration excitation or acoustic radiation force excitation
  • the detection wave includes but is not limited to ultrasonic waves or light waves, and optionally, vibration can be generated by mechanical vibration, acoustic radiation force or the like.
  • the medium vibrates and the vibration propagates in the medium. Since the velocity of vibration in the medium is limited, it is possible to track the propagation mode of the vibration using ultrasonic waves, light waves or other waves with a relatively fast propagation speed.
  • the propagation mode of the vibration in the medium is reflected by the detection wave echo signal of the medium under vibration excitation.
  • the viscoelasticity of the medium is an important factor in determining the mode of vibration propagation in the medium.
  • the medium Under vibration excitation, the medium will produce corresponding propagation states at different times, and the propagation state changes along time to form a propagation mode.
  • the propagation state refers to the state of motion of the medium at a certain moment, and the mode of propagation is the change of the propagation state of the medium along time.
  • the vibration excitation is one of a continuous or pulsed mechanical vibration and an acoustic radiation force pulse
  • the motion range of the medium under vibration excitation is 0.01 micrometer to 10 millimeters
  • the motion frequency of the medium under vibration excitation is 20 Hz to 2500 Hz with a duration of 50 microseconds to 1 second.
  • the resulting propagation states are different and further cause differences in the detected echo signals.
  • the data set stores a propagation mode sample of the medium sample with known viscoelastic information, and the corresponding mode viscoelasticity can be determined by searching the propagation mode sample corresponding to the propagation mode in the propagation mode data set.
  • the medium viscoelasticity may include a combination of at least one or more of shear modulus, Young's modulus, shear viscoelasticity, shear viscosity, mechanical impedance, mechanical relaxation time, and anisotropy.
  • the viscoelasticity comprises at least one of viscosity and elasticity.
  • the viscoelasticity information may include viscous information, or viscous information and elasticity information.
  • the viscoelastic information may include elastic information, or sticky information and elastic information.
  • the viscoelastic information may include viscous information and elasticity information.
  • the method may further include:
  • the stored vibration excitation, the detection of the echo signal of the wave and the viscoelasticity of the medium can be used for matching matching in the subsequent measurement of the viscoelasticity of the medium.
  • the embodiment of the invention can find the medium sample with the highest degree of similarity to the medium to be measured in the propagation mode data set, and determine the viscoelasticity of the medium to be measured by the propagation mode sample of the medium sample under vibration excitation, and can perform motion estimation and feature without When the point is selected, the measurement result of the viscoelasticity of the medium is obtained, and the amount of calculation is greatly reduced, and the measurement speed is remarkably accelerated.
  • the vibration excitation is shear wave excitation
  • the detection wave is ultrasonic wave
  • the detection wave echo signal is an ultrasonic echo signal
  • another embodiment of the present invention discloses a method for measuring the viscoelasticity of the medium, as shown in FIG. 2 . Show, including:
  • the propagation mode data set includes propagation mode samples generated by the plurality of medium samples of different viscoelasticity respectively under at least one vibration excitation.
  • the propagation mode data set can also be obtained in advance by experiment or simulation analysis, and stored in a local server or a cloud server, so that the data information can be read or called conveniently when used.
  • the vibration excitation pulse repetition frequency is 10 to 20000 Hz
  • the detection wave echo signal includes at least 100 consecutive detection wave echo data.
  • the method may further include:
  • the saved shear wave excitation, the ultrasonic echo signal, and the viscoelasticity of the medium can be used to perform lookup matching in the subsequent measurement of the viscoelasticity of the medium.
  • the propagation mode data set may be obtained by means of simulation calculation, or may be obtained by statistically summarizing a large amount of experimental data or measured data, or may be a combination of the two methods.
  • S203 can further include:
  • S2031 Obtain a target propagation mode sample that matches a propagation mode of the ultrasound echo signal in the propagation mode data set;
  • S2032 Determine a viscoelasticity of the target medium sample corresponding to the target propagation mode sample as the viscoelasticity of the medium.
  • the propagation mode data set can store multiple sets of data. Each set of data records the acquisition and processing results of dynamic imaging information of a medium sample over time under a vibration excitation, that is, the propagation mode of the detected echo signals.
  • the propagation mode data set may store at least one medium sample, the propagation mode samples generated by the at least one shear wave excitation, and the propagation mode data set, and the medium sample includes a viscoelasticity of the medium sample.
  • One or more attribute parameters have been pre-stored. Therefore, when the technical solution disclosed by the embodiment of the present invention is implemented by a person skilled in the art, the propagation mode data can be transmitted according to the specific shear wave used in the measurement process and the obtained propagation mode of the corresponding ultrasonic echo signal.
  • the target target propagation mode samples are collectively found, the target medium samples corresponding to the target propagation mode samples are determined, and then the target medium sample viscoelasticity is determined as the medium viscoelasticity to be measured.
  • the method for matching the obtained propagation mode and the propagation mode sample to determine the target propagation mode sample may be any one of the pattern matching methods, which is not limited by the embodiment of the present invention.
  • Another embodiment of the present invention discloses a method for measuring viscoelasticity of a medium, as shown in FIG. 3, including:
  • the propagation mode data set is determined according to propagation mode samples generated by the plurality of medium samples of different viscoelasticity under at least one vibration excitation.
  • the processed signal may be a direction-filtered detected echo signal, or may be a Fourier-filtered detected echo signal, or a filtered filtered echo signal, which is an embodiment of the present invention. This is not limited.
  • the propagation mode data set stores a correspondence relationship between the propagation mode and the viscoelasticity of the medium under vibration excitation. According to the vibration excitation and propagation mode, the corresponding medium viscoelasticity can be determined by searching in the propagation mode data set.
  • the embodiment of the invention is based on the data set.
  • searching and comparing the propagation modes the measurement result of the viscoelasticity of the medium can be obtained without performing motion estimation and feature point selection, and the calculation amount is greatly reduced, and the measurement speed is significantly accelerated.
  • the processed signal is obtained, and the propagation mode is obtained according to the processed signal, so that the propagation mode of the detected echo signal can be obtained more quickly and accurately.
  • the vibration excitation is shear wave excitation
  • the detection wave is ultrasonic wave
  • the detection wave echo signal is an ultrasonic echo signal
  • the data set is a propagation mode data set
  • the embodiment of the present invention also discloses another medium viscosity.
  • the elastic measurement method includes:
  • the propagation mode data set can also be obtained in advance by experiment or simulation analysis, and stored in a location such as a local server or a cloud server, so that the data information can be easily read or used when the propagation mode data set is used. transfer.
  • S404 can further include:
  • S4042 Determine a viscoelasticity of the target medium sample corresponding to the target propagation mode sample as the medium viscoelasticity.
  • the method may further include:
  • the shear wave excitation, the propagation mode, and the viscoelasticity of the medium are stored in the propagation mode data set.
  • the saved shear wave excitation, propagation mode, and viscoelasticity of the medium can be used to perform lookup matching during subsequent viscoelasticity measurement of the medium.
  • the embodiment of the invention further discloses a measuring device 50 for viscoelasticity of a medium, as shown in FIG. 5, comprising:
  • the probe 501 is configured to acquire a detection wave echo signal of the medium under vibration excitation
  • the processor 503 is configured to acquire a propagation mode of the detection wave echo signal acquired by the probe;
  • a memory 502 configured to store a propagation mode data set, where the propagation mode data set stores a propagation mode sample of the medium sample with known viscoelastic information;
  • the processor 503 is further configured to match the propagation mode with the propagation mode samples stored in the propagation mode data to determine the viscoelasticity of the medium.
  • the probe 501 can also be used to obtain an ultrasonic echo signal of the medium excited by the shear wave;
  • the processor 503 is further configured to acquire a propagation mode of the ultrasonic echo signal acquired by the probe;
  • the memory 502 can also be used to store a propagation mode sample of a medium sample of known viscoelastic information under shear wave excitation;
  • the processor 503 is further configured to match the propagation mode with the propagation mode samples stored in the propagation mode data to determine the viscoelasticity of the medium.
  • the processor 503 is further configured to determine the data set according to the propagation mode samples generated by the plurality of media samples of different viscoelasticity under the excitation of the at least one shear wave.
  • the processor 503 may further determine a propagation mode sample according to the ultrasonic echo signal samples generated by the plurality of media samples of different viscoelasticity under the at least one vibration excitation; and determine the propagation mode data set according to the propagation mode sample. .
  • the processor 503 is further configured to obtain a target propagation mode sample that matches the propagation mode in the propagation mode data set, and determine that the target media sample viscoelasticity corresponding to the target propagation mode sample is the medium viscoelasticity.
  • measuring device shown in FIG. 5 can be used to perform all the steps in the measuring methods shown in FIG. 1 and FIG. 2, and the related content has been described in the foregoing embodiments, and details are not described herein again.
  • the embodiment of the present invention further discloses a measuring device 60 for viscoelasticity of a medium. As shown in FIG. 6, the method includes:
  • the probe 601 is configured to acquire a detection wave echo signal of the medium under vibration excitation
  • a filter 602 configured to acquire a processed signal, where the processed signal is a detected echo signal acquired by the filtered probe 601;
  • the processor 604 is configured to acquire a propagation mode according to the processed signal acquired by the filter 602.
  • a memory 603 configured to store a propagation mode data set, wherein the propagation mode data set stores a propagation mode sample of the medium sample of the known viscoelastic information under vibration excitation;
  • the processor 604 is further configured to match the propagation mode with the propagation mode samples stored in the propagation mode data to determine the viscoelasticity of the medium.
  • the probe 601 can also be used to obtain an ultrasonic echo signal of the medium excited by the shear wave;
  • the filter 602 is further configured to acquire a processed signal, where the processed signal is an ultrasonic echo signal acquired by the filtered probe 601;
  • the processor 604 is further configured to acquire a propagation mode according to the processed signal acquired by the filter 602.
  • the memory 603 is further configured to store a propagation mode data set, wherein the propagation mode data set stores a propagation mode sample of the medium sample of the known viscoelastic information under the excitation of the shear wave;
  • the processor 604 is further configured to match the propagation mode with the propagation mode samples stored in the propagation mode data to determine the viscoelasticity of the medium.
  • the processor 604 is further configured to determine a propagation mode sample according to the ultrasonic echo signal samples generated by the plurality of media samples of different viscoelasticity under the at least one vibration excitation, and determine the data set according to the propagation mode sample. .
  • the processor 604 is further configured to obtain a target propagation mode sample that matches the propagation mode in the propagation mode data set;
  • the processor 604 is further configured to save the shear wave excitation, the processing signal, and the medium viscoelasticity in the propagation mode data set stored in the memory 603.
  • measuring device shown in FIG. 6 can be used to perform all the steps in the measuring methods shown in FIG. 3 and FIG. 4, and the related content has been described in the foregoing embodiments, and details are not described herein again.

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  • Acoustics & Sound (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

L'invention concerne un procédé de mesure de la viscoélasticité d'un milieu comprenant : l'obtention d'un signal d'écho d'onde détectée d'un milieu soumis à une excitation de vibration ; l'obtention du mode de propagation du signal d'écho d'onde détectée, et la mise en correspondance dudit mode de propagation avec un échantillon de mode de propagation mémorisé dans un ensemble de données de modes de propagation afin de déterminer la viscoélasticité du milieu ; ledit ensemble de données étant déterminé en fonction des échantillons de mode de propagation générés par différents échantillons de milieu, présentant des viscoélasticités différentes, soumis à au moins une excitation de vibration. L'invention concerne également un appareil (50) permettant de mesurer la viscoélasticité d'un milieu, comprenant une sonde (501) utilisée pour obtenir un signal d'écho d'onde détectée d'un milieu soumis à une excitation par vibration, un processeur (503) utilisé pour obtenir le mode de propagation du signal d'écho d'onde détectée et un dispositif de mémorisation (502) utilisé pour mémoriser l'ensemble de données de mode de propagation. Ledit processeur (503) est également utilisé pour mettre en correspondance le mode de propagation avec un échantillon de mode de propagation mémorisé dans l'ensemble de données de mode de propagation, et déterminer la viscoélasticité du milieu.
PCT/CN2018/088407 2017-07-21 2018-05-25 Procédé et appareil de mesure de viscoélasticité d'un milieu WO2019015399A1 (fr)

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CN107478723A (zh) * 2017-07-21 2017-12-15 无锡海斯凯尔医学技术有限公司 介质粘弹性的测量方法和装置

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