WO2019015396A1 - Procédé et dispositif de mesure de viscoélasticité d'un milieu - Google Patents

Procédé et dispositif de mesure de viscoélasticité d'un milieu Download PDF

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Publication number
WO2019015396A1
WO2019015396A1 PCT/CN2018/088404 CN2018088404W WO2019015396A1 WO 2019015396 A1 WO2019015396 A1 WO 2019015396A1 CN 2018088404 W CN2018088404 W CN 2018088404W WO 2019015396 A1 WO2019015396 A1 WO 2019015396A1
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echo signal
medium
time
ultrasonic echo
data set
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PCT/CN2018/088404
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English (en)
Chinese (zh)
Inventor
何琼
邵金华
孙锦
段后利
王强
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无锡海斯凯尔医学技术有限公司
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Publication of WO2019015396A1 publication Critical patent/WO2019015396A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves

Definitions

  • the present invention relates to the field of measurement technology, and in particular to a method and apparatus for measuring the viscoelasticity of a medium.
  • the position time map is usually a straight twill pattern.
  • the slope is determined by the distance traveled by the vibration per unit time, that is, the speed at which the vibration propagates.
  • the speed of vibration propagation is related to the viscoelasticity of the medium. Therefore, when vibrating the medium, the viscoelasticity of the medium can be measured by measuring the propagation characteristics of the vibration.
  • the feature points need to be selected, and the feature points at different moments and different positions are linearly fitted, and the quantitative parameters of the dynamic ultrasonic viscoelastic imaging are obtained.
  • the feature points are determined by the displacement or strain of the medium when the vibration propagates in the medium.
  • motion estimation is required to obtain information such as displacement or strain of the medium, and then subsequent operations are performed.
  • this method has the problems of large computational complexity and complex feature point selection for motion estimation.
  • Embodiments of the present invention provide a method and apparatus for measuring the viscoelasticity of a medium.
  • the invention aims to solve the problem that the calculation amount required for motion estimation in the viscoelasticity measurement of the medium in the prior art is large, and the feature points are selected to be complicated.
  • This generalization is not a general comment, nor is it intended to identify key/critical constituent elements or to describe the scope of protection of these embodiments. Its sole purpose is to present some concepts in a simplified form as a prelude to the following detailed description.
  • an embodiment of the present invention provides a method for measuring a viscoelasticity of a medium, including:
  • the data set stores the detected wave echo signal samples of the medium sample with known viscoelastic information under vibration excitation.
  • the vibration excitation is shear wave excitation
  • the detection wave echo signal is an ultrasonic echo signal
  • the data set is an ultrasonic signal data set.
  • it also includes:
  • the ultrasonic echo data is loaded into the propagation mode data stored in the propagation mode data to generate an ultrasonic echo signal sample;
  • the propagation mode data includes propagation state data of the medium samples of known viscoelastic information at various moments under a given vibration excitation.
  • acquiring an ultrasonic echo signal of the medium under vibration excitation comprising: acquiring an ultrasonic echo signal of the medium under vibration excitation from a second time t2;
  • Matching the detected wave echo signal with the detected echo echo signal sample stored in the data set includes: matching one or more of the ultrasonic echo signals acquired from the second time t2 with the ultrasonic echo signal sample;
  • the second time t2 is after the vibration excitation.
  • it also includes:
  • the ultrasonic echo signal is time aligned and spatially aligned with the ultrasonic echo signal sample prior to matching.
  • the time alignment includes: determining a time difference, where the time difference is a difference between the second time t2 and the vibration excitation start time, and a difference between the second time t2 and the first time t1; performing time matching according to the time difference quasi;
  • Spatial alignment includes determining the boundary and depth of the medium for spatial alignment, or spatial alignment based on the preset depth.
  • the propagation mode data set includes propagation state data generated by the different viscoelastic different media samples at one or more times under the excitation of at least one shear wave.
  • the vibration excitation comprises: one of a continuous or pulsed mechanical vibration and an acoustic radiation force pulse;
  • the medium has a range of motion from 0.01 micron to 10 mm under vibration excitation;
  • the medium has a frequency of vibration from 20 Hz to 2500 Hz and a duration of 50 microseconds to 1 second.
  • the detection wave echo signal is an ultrasonic echo signal; the vibration excitation pulse repetition frequency is 10 to 20000 Hz; and the detection wave echo signal includes at least 100 consecutive detection wave echo data.
  • the viscoelasticity includes at least one of viscosity and elasticity; when the viscoelasticity is viscous, the viscoelastic information includes viscous information, or viscous information and elastic information; when the viscoelasticity is elasticity, the viscoelastic information includes elastic information. Or viscous information and elastic information; when viscoelasticity is viscous and elastic, viscoelastic information includes viscous information and elastic information.
  • an embodiment of the present invention provides a measuring device for viscoelasticity of a medium, including:
  • a memory for storing a data set, wherein the data set stores a sample of the detected wave echo signal of the medium sample with known viscoelastic information under vibration excitation;
  • the processor is configured to match the detected wave echo signal with the detected wave echo signal sample in the data set to determine the viscoelastic information of the medium.
  • the vibration excitation is shear wave excitation
  • the detection wave echo signal is an ultrasonic echo signal
  • the data set is an ultrasonic signal data set.
  • the probe is further configured to acquire the ultrasonic echo data at the first time t1;
  • the processor is further configured to load the ultrasonic echo data into the propagation mode data stored in the propagation mode data to generate the ultrasonic echo signal sample; and generate the ultrasonic signal data set;
  • the propagation mode data includes propagation state data of the medium samples of known viscoelastic information at various moments under a given vibration excitation.
  • the probe is further configured to acquire an ultrasonic echo signal of the medium under vibration excitation from the second time t2;
  • the processor is further configured to: match one or more of the ultrasonic echo signals acquired from the second time t2 with the ultrasonic echo signal samples;
  • the second time t2 is after the vibration excitation.
  • the processor is further configured to time align and spatially align the ultrasonic echo signal with the ultrasonic echo signal sample before the matching.
  • the time alignment includes: determining a time difference, where the time difference is a difference between the second time t2 and the vibration excitation start time, and a difference between the second time t2 and the first time t1; performing time matching according to the time difference quasi;
  • Spatial alignment includes determining the boundary and depth of the medium for spatial alignment, or spatial alignment based on the preset depth.
  • the propagation mode data set includes propagation state data generated by the different viscoelastic different media samples at one or more times under the excitation of at least one shear wave.
  • the measuring method of the viscoelasticity of the medium disclosed in the embodiment of the invention finds the detecting wave of the known viscoelastic medium sample with the highest degree of similarity to the detected wave echo signal of the medium to be measured under vibration excitation in the data set under vibration excitation.
  • the echo signal samples are used to determine the viscoelasticity of the medium to be measured, and the viscoelasticity of the medium can be obtained without motion estimation and feature point selection, the calculation amount is greatly reduced, and the measurement speed is significantly accelerated.
  • FIG. 1 is a flow chart of a method for measuring viscoelasticity of a medium according to an embodiment of the present invention
  • FIG. 2 is a flow chart of another method for measuring viscoelasticity of a medium disclosed in an embodiment of the present invention.
  • FIG. 3 is a schematic diagram of an ultrasonic echo signal disclosed in an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of an ultrasonic echo data disclosed in an embodiment of the present invention.
  • FIG. 5 is a schematic diagram of an ultrasonic echo signal sample disclosed in an embodiment of the present invention.
  • FIG. 6 is a schematic diagram of an ultrasonic echo signal sample disclosed in an embodiment of the present invention.
  • FIG. 7 is a schematic diagram of an ultrasonic echo signal sample disclosed in an embodiment of the present invention.
  • FIG. 8 is a schematic diagram of an ultrasonic echo signal sample disclosed in an embodiment of the present invention.
  • FIG. 9 is a schematic diagram of a measuring device for viscoelasticity of a medium disclosed in an embodiment of the invention.
  • the embodiment of the invention discloses a method for measuring the viscoelasticity of a medium, as shown in FIG. 1 , comprising the following steps.
  • S102 Matching the detected wave echo signal with the detected wave echo signal sample stored in the data set to determine the viscoelastic information of the medium, wherein the data set stores the detected wave back of the medium sample with known viscoelastic information under vibration excitation. Wave signal sample.
  • the vibration excitation includes, but is not limited to, mechanical vibration excitation or acoustic radiation force excitation.
  • the mechanical vibration excitation and the acoustic radiation force excitation may be continuous or pulsed.
  • the motion of the medium under vibration excitation may range from 0.01 micrometers to 10 millimeters, and the medium may be subjected to vibration excitation at a frequency of 20 Hz to 2500 Hz for a duration of 50 microseconds to 1 second.
  • the detection wave includes, but is not limited to, ultrasonic waves or light waves.
  • vibration vibration is applied to the medium by mechanical vibration, acoustic radiation force or other means that can generate vibration.
  • the medium generates vibration and the vibration propagates in the medium. Since the velocity of vibration in the medium is limited, it is possible to track the propagation mode of the vibration using ultrasonic waves, light waves or other waves with a relatively fast propagation speed.
  • the propagation mode of the vibration in the medium is reflected by the detection wave echo signal of the medium under vibration excitation.
  • the detection wave echo signal may be an ultrasonic echo signal, and the vibration excitation pulse repetition frequency is 10 to 20,000 Hz.
  • the detected wave echo signal over a period of time consists of the detected wave echo data at a series of times during this time.
  • the detection wave echo signal may include at least 100 consecutive frames of detection wave echo data.
  • the viscoelasticity of the medium is an important factor in determining the mode of vibration propagation in the medium.
  • the medium Under vibration excitation, the medium will produce corresponding propagation states at different times, and the propagation state changes along time to form a propagation mode.
  • the propagation state refers to the state of motion of the medium at a certain moment, and the mode of propagation is the change of the propagation state of the medium along time.
  • the resulting propagation states are different and further cause differences in the detected echo signals.
  • the data set stores the viscoelasticity of the medium sample and the detected wave echo signal sample of the medium sample under vibration excitation, and according to the vibration excitation and the detection wave echo signal, performing matching and matching in the data set can determine the corresponding The medium is viscoelastic.
  • the medium viscoelasticity may include a combination of at least one or more of shear modulus, Young's modulus, shear viscoelasticity, shear viscosity, mechanical impedance, mechanical relaxation time, and anisotropy.
  • the viscoelasticity comprises at least one of viscosity and elasticity.
  • the viscoelastic information may include viscous information, or viscous information and elasticity information.
  • the viscoelastic information may include elastic information, or sticky information and elastic information.
  • the viscoelastic information may include viscous information and elasticity information.
  • the measuring method of the viscoelasticity of the medium disclosed in the embodiment of the present invention finds the known viscoelastic medium sample having the highest degree of similarity with the detected echo signal of the medium to be measured under vibration excitation in the data set under vibration excitation.
  • the wave echo signal samples are detected to determine the viscoelasticity of the medium to be measured, and the viscoelasticity of the medium can be obtained without motion estimation and feature point selection, the calculation amount is greatly reduced, and the measurement speed is significantly accelerated.
  • the vibration excitation is shear wave excitation
  • the detection wave is ultrasonic wave
  • the detection wave echo signal is an ultrasonic echo signal
  • the data set is an ultrasonic signal data set
  • the embodiment of the present invention also discloses another medium viscosity.
  • the elastic measurement method includes the following steps.
  • the data set can store multiple sets of data, and each set of data records the ultrasonic echo signals generated by the medium under a shear wave excitation. Further, the ultrasonic signal data set may store the ultrasonic echo signal samples generated by the at least one medium sample respectively under the excitation of at least one shear wave, and the data set, the medium sample includes one or more of the viscoelasticity of the medium sample. A variety of attribute parameters have been pre-stored.
  • the method for matching the obtained ultrasonic echo signals with the ultrasonic echo signal samples to determine the target ultrasonic echo signal samples may be any pattern matching method, which is not limited by the embodiment of the present invention.
  • S201 optionally, those skilled in the art can directly monitor and obtain the ultrasonic echo signal within a preset time range with reference to the disclosure of the present invention.
  • an example of an ultrasonic echo signal is shown in Figure 3.
  • the Applicant displays the ultrasound radio frequency data in logarithmic compression of its envelope amplitude (display range 60 dB).
  • the ultrasound signal data set may also be formed, including:
  • S205 Generate an ultrasound signal data set, where the propagation mode data includes propagation state data of the medium samples at various moments under vibration excitation.
  • the at least one ultrasound echo signal sample is determined according to the ultrasound echo data and the propagation mode data set at time t1, and the ultrasound signal data set is determined according to the determined at least one ultrasound echo signal sample.
  • the ultrasonic echo data is acquired at the first time t1, and may be ultrasonic echo data generated when the medium is not excited by vibration, or ultrasonic echo data generated by the medium under vibration excitation.
  • An example of the ultrasonic echo data generated when no vibration excitation is applied is shown in FIG.
  • the propagation mode may include multiple propagation states, that is, the propagation mode may include a propagation state corresponding to multiple moments. Therefore, further optionally, the propagation mode data set may store a propagation mode of the medium excited by the shear wave, for example, the propagation mode data set includes different medium samples of different viscoelasticity, respectively, under at least one shear wave excitation. Propagation state data generated at one or more times.
  • a specific excitation is applied to the tissue of different given viscoelastic characteristics, and the obtained propagation states of the series of ultrasonic signals at different times are combined.
  • the collection is stored as a propagation mode data set.
  • the ultrasound echo signal samples can be determined based on the propagation mode.
  • the ultrasonic echo signal samples may have a one-to-one correspondence with the propagation modes, or the ultrasonic echo signal samples may correspond to a plurality of propagation modes, or the ultrasonic echo signal samples have other forms of correspondence with the propagation modes.
  • the ultrasound echo data set may include at least the ultrasonic echo signal samples as shown in FIGS. 5 to 8, wherein the ultrasonic echo signal samples shown in FIGS. 5 to 8 are respectively ultrasonically reflected by FIG.
  • the propagation mode data set generated in the wave data loading system is generated.
  • the applicant also displays the generated ultrasonic RF data by logarithmic compression of its envelope amplitude (display range 60 dB)
  • the ultrasonic echo signal is matched with the ultrasonic echo signal sample.
  • the ultrasonic echo signal shown in FIG. 3 can be searched with the ultrasonic echo signal sample shown in FIG. 5 to FIG. Comparison.
  • the sum of the squares of the difference between the ultrasonic echo signal and the ultrasonic echo signal sample is obtained during the search or comparison, and the ultrasonic echo sample corresponding to the minimum value of the calculation result is determined as the ultrasonic echo matched with the ultrasonic echo signal.
  • the wave signal sample that is, the ultrasonic echo signal shown in FIG. 3 is determined to match the ultrasonic echo signal sample shown in FIG.
  • the invention does not limit the method of comparison.
  • S201 may include: acquiring, at a second time t2, an ultrasonic echo signal of the medium under vibration excitation, that is, a time at which the ultrasonic echo signal is acquired is recorded as t2.
  • S202 may include: matching the ultrasonic echo signal acquired at the third time t3 with the ultrasonic echo signal sample, wherein the third time t3 is greater than or equal to the second time t2.
  • the time t3 may coincide with the time t2, or may be later than the time t2.
  • the method may further include:
  • S206 can include:
  • S2061 Determine a time difference, wherein the time difference is a difference between a difference between the second time t2 and the vibration excitation start time, and a difference between the second time t2 and the first time t1;
  • S2062 Perform time alignment according to the time difference.
  • the time difference is ⁇ t
  • the ultrasonic echo signal acquired at time t3 can be matched with the ultrasonic echo signal sample at time ⁇ t, and further, at time t3 It can coincide with the time t2; when the time t1 is later than the time t2, the ultrasonic echo signal acquired at time t3 can be matched with the ultrasonic echo signal sample, and further, the time difference after time t3 is later than t2 is ⁇ t.
  • the method further includes: spatially aligning the ultrasonic echo signal with the ultrasonic echo signal sample, wherein the spatial alignment may include: determining a boundary and a depth of the medium, performing spatial alignment; or Set the depth of interest for spatial alignment.
  • one or more ultrasonic echo signals may be acquired from time t2, and in S202, one or more ultrasonic echo signals may be matched with the ultrasonic echo signal samples.
  • the ultrasonic echo signal samples with the highest matching degree are selected as the ultrasonic echo signal samples for determining the viscoelasticity of the medium.
  • Embodiments of the present invention only pre-store a propagation mode data set in the system, including propagation mode data for one or more media samples.
  • the propagation mode data is a propagation state of a series of ultrasonic echo signals obtained at subsequent different moments after actual measurement or simulation by applying a specific excitation to one or more known viscoelastic information. Collection.
  • the ultrasonic echo data acquired at a certain time in the current measurement is loaded with the propagation mode data of the medium sample of the known viscoelastic information stored in the propagation mode data set to generate the ultrasonic signal data set.
  • the ultrasound signal data set includes a sequence of corresponding ultrasound echo samples of one or more media samples under current excitation.
  • the ultrasonic echo signals acquired subsequently are matched with the ultrasonic signal samples in the ultrasonic signal data set, and the measurement results of the viscoelasticity of the medium can be obtained by simply comparing the samples with the highest similarity, thereby avoiding more complicated motion estimation and feature point selection. And need to store and obtain less information, simple to implement, and low cost.
  • the embodiment of the invention further discloses a measuring device 30 for viscoelasticity of a medium, as shown in FIG. 13, comprising:
  • a probe 301 configured to acquire a detection wave echo signal of the medium under vibration excitation
  • a memory 302 configured to store a data set, wherein the data set stores a sample of the detected wave echo signal of the medium sample with known viscoelastic information under vibration excitation;
  • the processor 303 is configured to match the detected wave echo signal with the detected wave echo signal sample in the data set to determine the viscoelastic information of the medium.
  • the probe 301 can be used to perform the steps of S101 or S201, and the processor 303 can be used to perform the steps of S102 or S202.
  • the data set stored in the memory 302 can be referred to the content disclosed in the foregoing embodiment. Narration.
  • the detection wave echo signal of the medium acquired by the probe 301 under vibration excitation may be an ultrasonic echo signal of the medium excited by the shear wave
  • the data set stored by the memory 302 may be an ultrasonic signal data set.
  • the probe 301 is further configured to acquire ultrasonic echo data at the first time t1;
  • the processor 303 is further configured to load the ultrasonic echo data into the propagation mode data stored in the propagation mode data, generate the ultrasonic echo signal sample, and generate the ultrasonic signal data set.
  • the propagation mode data includes propagation state data of the medium samples of known viscoelastic information at various moments under a given vibration excitation.
  • the probe 301 is further configured to acquire an ultrasonic echo signal of the medium under vibration excitation from the second time t2;
  • the processor is further operative to match one or more of the ultrasonic echo signals acquired from the second instant t2 with the ultrasonic echo signal samples, wherein the second instant t2 is after the vibration excitation.
  • the processor 303 is further configured to: time align and spatially align the ultrasonic echo signal with the ultrasonic echo signal sample before the matching, wherein the time alignment is used to determine the third time t3.
  • the time alignment includes: determining a time difference, wherein the time difference is a difference between the second time t2 and the vibration excitation start time, and a difference between the second time t2 and the first time t1, and the time difference is performed according to the time difference.
  • spatial alignment includes: determining a boundary and a depth of the medium for spatial alignment; or performing spatial alignment based on the preset depth.
  • the propagation mode data set may include propagation state data generated by the different viscoelastic different media samples at one or more times under at least one shear wave excitation.
  • measuring apparatus shown in FIG. 13 can be used to perform all the steps in the measuring methods shown in FIG. 1 and FIG. 2, and the related content has been described in the foregoing embodiments, and details are not described herein again.

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Abstract

La présente invention concerne un procédé et un dispositif de mesure de la viscoélasticité d'un milieu, qui se rapportent au domaine technique de la mesure. Le procédé de mesure de la viscoélasticité d'un milieu comprend les étapes consistant à : acquérir un signal d'écho d'onde de détection d'un milieu lorsque celui-ci est excité par vibration (S101), mettre en correspondance le signal d'écho d'onde de détection avec un échantillon de signal d'écho d'onde de détection qui est stocké dans un ensemble de données, et déterminer des informations de viscoélasticité du milieu ; l'ensemble de données stocke des échantillons de signal d'écho d'onde de détection d'échantillons de milieu ayant des informations de viscoélasticité connues lorsqu'ils sont excités par vibration (S102). En recherchant dans l'ensemble de données l'échantillon de signal d'écho d'onde de détection d'un échantillon de milieu ayant une viscoélasticité connue lorsqu'il est excité par vibration qui est la plus similaire à un signal d'écho d'onde de détection d'un milieu à mesurer lorsque celui-ci est excité par vibration, la viscoélasticité du milieu à mesurer peut être déterminée. La viscoélasticité d'un milieu peut être obtenue sans effectuer d'estimation de mouvement et de sélection de point caractéristique, le nombre de calculs est fortement réduit, et la vitesse de mesure est considérablement accélérée.
PCT/CN2018/088404 2017-07-21 2018-05-25 Procédé et dispositif de mesure de viscoélasticité d'un milieu WO2019015396A1 (fr)

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CN110045371A (zh) * 2019-04-28 2019-07-23 软通智慧科技有限公司 一种鉴定方法、装置、设备及存储介质
CN115856083A (zh) * 2023-02-27 2023-03-28 中国汽车技术研究中心有限公司 汽车碰撞假人皮肤的性能测试方法、装置、设备和介质

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