WO2019015102A1 - 一种用于治疗急性胰腺炎的中药 - Google Patents

一种用于治疗急性胰腺炎的中药 Download PDF

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WO2019015102A1
WO2019015102A1 PCT/CN2017/103553 CN2017103553W WO2019015102A1 WO 2019015102 A1 WO2019015102 A1 WO 2019015102A1 CN 2017103553 W CN2017103553 W CN 2017103553W WO 2019015102 A1 WO2019015102 A1 WO 2019015102A1
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acute pancreatitis
chinese medicine
traditional chinese
bupleurum
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PCT/CN2017/103553
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French (fr)
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田丽华
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淄博夸克医药技术有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating acute pancreatitis.
  • Acute pancreatitis is a disease caused by various causes of pancreatic enzyme activation, with local inflammation of the pancreas as the main feature, with or without other organ function changes. It is one of the common acute abdomen diseases in clinical practice. The main cause is biliary tract disease. Overeating, excessive drinking, etc., its incidence rate increases with the continuous improvement of material living standards, its pathogenesis is dangerous, complications, high mortality, and its mechanism has not been fully elucidated. There is no "pancreatitis" in the motherland medicine, but the ancient literature has a lot of similarities with the symptoms of pancreatitis.
  • stomach sputum is heartache, both flank, pharyngeal phlegm, stomach pain. Its disease characteristics belong to the category of “abdominal pain”, “stomach heartache” and “stomach pain” in the motherland medicine. The main clinical manifestations are acute severe abdominal pain, nausea, vomiting, and increased pancreatic enzyme.
  • Bupleurum [alias] smoked, simmered, mountain vegetables, grass, firewood.
  • This product is the dried root of Bupleurum or Bupleurum chinense. According to different traits, they are respectively called “North Bupleurum” and “South Bupleurum”. Excavation in spring and autumn, remove stems and leaves and sediment, and dry. [Sexual taste] bitter, slightly cold. [Return] to the liver, gallbladder. [Functions and Indications] In the solution table, Shugan, Shengyang. For colds and fever, cold and heat, chest pain, pain, irregular menstruation, prolapse, prolapse. [Usage and dosage] Oral: Jiantang, 3 ⁇ 9g. [Note] The dried rhizome of Bupleurum chinense has a dense surface and is toxic. It should not be used as Bupleurum. [Excerpt] "Chinese Materia Medica”.
  • Pinellia [alias] three leaves and half summer, three leaves old, three steps, Ma Yu fruit, swallow tail, geography, water jade. [Source] This product is a dry tuber of Pinellia ternata. Excavate in summer and autumn, wash, remove the skin and fibrous roots, and dry. [Sexual taste] Xin, warm; poisonous. [Return] to the spleen, stomach, lung. ⁇ Functions and Indications ⁇ Dry and phlegm, reduce vomiting, eliminate phlegm and disperse.
  • Ginger [alias] ginger. [Source] This product is the fresh rhizome of gingeraceae ginger. Autumn And Winter Digging in the second season to remove the roots and sediment. [Sexual taste] Xin, lukewarm. [Return] to the lungs, spleen, stomach. ⁇ Functions and Indications ⁇ Solve the cold, stop the vomiting, relieve phlegm and relieve cough. For cold, cold, stomach vomiting, cold and cough. [Usage and dosage] Oral: Jiantang, 3 ⁇ 9g. [Note] It takes a long time to eat ginger and accumulate heat. People who eats sick and eats more wine and has a quick hair. People with acne eat more meat and have bad meat. [Excerpt] "Chinese Materia Medica”.
  • Jujube [alias] [source] This product is a dry mature fruit of the jujube plant. When the autumn fruit is ripe, it is harvested and dried. Its roots and bark are also used as medicine and can be taken at any time. [Sexual taste] sweet, warm. [Return to the spleen] stomach, stomach. [Indications] Buzhong Yiqi, nourishing blood and soothe the nerves. For spleen deficiency, less food, fatigue, and impotence. Anti-inflammatory, stop bleeding, stop diarrhea. For bronchitis, enteritis, dysentery, uterine bleeding; external treatment of traumatic bleeding. Qi, blood, and menstruation. For irregular menstruation, red collapse, vaginal discharge.
  • Astragalus [alias] Camellia root, Astragalus tea, earthen tea root. [Source] This product is the dried root of the scutellariae of the Labiatae family. In the spring and autumn, the excavation is carried out to remove the roots and sediments. After drying, it hits the rough skin and is dried. [Sexual taste] bitter, cold. [Return] to the lungs, gallbladder, spleen, large intestine, small intestine. [Indications] Heat and dampness, purging fire and detoxification, stop bleeding, and fetus.
  • Cooked rhubarb [alias] Huang Liang, fire ginseng, skin such as, general, brocade rhubarb, Chuanjun, Jun, ⁇ rhubarb, beef tongue rhubarb, brocade, raw army, fragrant rhubarb, horseshoe yellow. [Source] This product is the dried root and rhizome of the palm leaf rhubarb, Tanggut rhubarb or medicinal rhubarb. At the end of autumn, the stems and leaves are withered or mined before the second spring, and the fine roots are removed, the outer skin is scraped off, the petals or segments are cut, and the strings are dried in a string or directly dried. [Sexual taste] bitter, cold.
  • Rhubarb charcoal cools blood stasis and stops bleeding. For hemorrhagic fever.
  • Excerpt "Chinese Materia Medica”.
  • the invention aims to provide a traditional Chinese medicine for treating acute pancreatitis, and achieve the purpose of safely and effectively curing acute pancreatitis by selecting an appropriate medicinal material and its ratio.
  • a traditional Chinese medicine for treating acute pancreatitis of eczema which is prepared from the following raw materials of weight ratio: 15 parts of Bupleurum, 10 parts of clam shell, 10 parts of medlar, 10 parts of astragalus, white ⁇ 12 parts, 10 parts of French mid-summer, 6 parts of cooked rhubarb, 15 parts of red dates, 3 parts of ginger.
  • pancreatitis According to the diagnostic criteria of the National Clinical Conference on Acute Pancreatitis: (1) The clinical manifestations of acute pancreatitis are acute persistent abdominal pain (without abdominal pain), and the increase of blood amylase activity is ⁇ 3 times of the upper limit of normal. Imaging studies suggest that the pancreas has or does not have morphological changes; other disorders may be excluded, with or without other organ dysfunction; in a few cases, serum amylase activity is normal or slightly elevated; (2), mild acute pancreatitis: with acute pancreatitis Clinical manifestations and biochemical changes without organ dysfunction or local complications. Good response to fluid supplementation.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention twice a day.
  • the course of treatment is 14 days.
  • the control group received oral metronidazole and quinolone antibiotics (according to the instructions) for 14 days.
  • the medicine prepared by the invention can safely and effectively treat acute pancreatitis, and has the promotion value.

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Abstract

一种治疗急性胰腺炎的中药，由以下重量配比的原料药材制成：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏10份，熟大黄6份，红枣15份，生姜3份。

Description

一种用于治疗急性胰腺炎的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗急性胰腺炎的中药。
背景技术
急性胰腺炎是多种病因引起胰酶激活，以胰腺局部炎症反应为主要特征，伴或不伴有其它器官功能改变的疾病，是临床上常见的急腹症之一，主要病因是胆道疾患、暴饮暴食、过度饮酒等，其发病率随着物质生活水平的不断调高而逐年提升，其病程凶险，并发症多、病死率高，其发生机制未完全阐明。祖国医学中并无“胰腺炎”之病名，但古代文献有大量与胰腺炎症状等相似的论述，“腹胀胸满，胃脘当心痛，支两胁，咽膈不通，胃心痛也。”根据其疾病特征归属于祖国医学“腹痛”“胃心痛”“胃脘痛”等范畴。临床主要以急性剧烈腹痛、恶心、呕吐、胰酶增高为主要表现。
本发明所涉及药材研究现状如下：
柴胡【别名】地熏、茈胡，山菜、茹草，柴草。【来源】本品为伞形科植物柴胡或狭叶柴胡的干燥根。按性状不同，分别习称“北柴胡”及“南柴胡”。春、秋二季采挖，除去茎叶及泥沙，干燥。【性味】苦，微寒。【归经】归肝、胆经。【功能主治】和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。【用法用量】内服：煎汤，3～9g。【注意】大叶柴胡的干燥根茎，表面密生环节，有毒，不可当柴胡用。【摘录】《中华本草》。
半夏【别名】三叶半夏、三叶老、三步跳、麻玉果、燕子尾、地文、水玉。【来源】本品为天南星科植物半夏的干燥块茎。夏、秋二季采挖，洗净，除去外皮及须根，晒干。【性味】辛，温；有毒。【归经】归脾、胃、肺经。【功能主治】燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。姜半夏多用于降逆止呕。【用法用量】内服：煎汤，3～9g。【注意】阴虚燥咳、津伤口渴、血证及燥痰者禁服，孕妇慎服。不宜与乌头类药材同用。【摘录】《中华本草》。
生姜【别名】姜。【来源】本品为姜科植物姜的新鲜根茎。秋、冬 二季采挖，除去须根及泥沙。【性味】辛，微温。【归经】归肺、脾、胃经。【功能主治】解表散寒，温中止呕，化痰止咳。用于风寒感冒，胃寒呕吐，寒痰咳嗽。【用法用量】内服：煎汤，3～9g。【注意】食姜久，积热患目。凡病痔人多食兼酒，立发甚速。痈疮人多食则生恶肉。【摘录】《中华本草》。
红枣【别名】【来源】本品为鼠李科枣属植物枣的干燥成熟果实。秋季果实成熟时采收，晒干。其根、树皮亦入药，随时可采。【性味】甘，温。【归经】归脾、胃经。【功能主治】补中益气，养血安神。用于脾虚食少，乏力便溏，妇人脏躁。消炎，止血，止泻。用于气管炎，肠炎，痢疾，崩漏；外用治外伤出血。行气，活血，调经。用于月经不调，红崩，白带。【用法用量】内服：煎汤，6～15g。【注意】凡有湿痰、积滞，齿病、虫病者，均不相宜。心下痞，中满呕吐者忌之。多食动风，脾反受病。【摘录】《中华本草》。
黄芩【别名】山茶根、黄芩茶、土金茶根。【来源】本品为唇形科植物黄芩的干燥根。春、秋二季采挖，除去须根及泥沙，晒后撞去粗皮，晒干。【性味】苦，寒。【归经】归肺、胆、脾、大肠、小肠经。【功能主治】清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。【用法用量】内服：煎汤，3-9g。【注意】山茱萸、龙骨为之使。恶葱实。畏丹砂、牡丹、藜芦。【摘录】《中华本草》。
枳实【来源】本品为芸香科植物酸橙及其栽培变种或甜橙的干燥幼果。5～6月收集自落的果实，除去杂质，自中部横切为两半，晒干或低温干燥，较小者直接晒干或低温干燥。【性味】苦、辛、酸，温。【归经】归脾、胃经。【功能主治】破气消积，化痰散痞。用于积滞内停，痞满胀痛，泻痢后重，大便不通，痰滞气阻胸痹，结胸；胃下垂，脱肛，子宫脱垂。【用法用量】内服：煎汤，3～9g。【注意】孕妇慎用。【摘录】《中华本草》。
白芍【别名】芍药。【来源】本品为毛茛科植物芍药的干燥根。夏、秋二季采挖，洗净，除去头尾及细根，置沸水中煮后除去外皮或去皮后再煮，晒干。【性味】苦、酸，微寒。【归经】归肝、脾经。【功能主治】平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。【用法用量】内服：煎汤，6～15g。【注意】不宜与藜芦同用。【摘录】《中 华本草》。
枳壳【来源】本品为芸香科植物酸橙及其栽培变种的干燥未成熟果实。7月果皮尚绿时采收，自中部横切为两半，晒干或低温干燥。【性味】苦、辛、酸，温。【归经】归脾、胃经。【功能主治】理气宽中，行滞消胀。用于胸胁气滞，胀满疼痛，食积不化，痰饮内停；胃下垂，脱肛，子官脱垂。【用法用量】内服：煎汤，3～9g。【注意】孕妇慎用。气血弱者不可服。【摘录】《中华本草》。
熟大黄【别名】黄良、火参、肤如、将军、锦纹大黄、川军、峻、蜀大黄、牛舌大黄、锦纹、生军、香大黄、马蹄黄。【来源】本品为蓼科植物掌叶大黄、唐古特大黄或药用大黄的干燥根及根茎。秋末茎叶枯萎或次春发芽前采挖，除去细根，刮去外皮，切瓣或段，绳穿成串干燥或直接干燥。【性味】苦，寒。【归经】归脾、胃、大肠、肝、心包经。【功能主治】泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，外治水火烫伤；上消化道出血。酒大黄善清上焦血分热毒。用于目赤咽肿，齿龈肿痛。熟大黄泻下力缓，泻火解毒。用于火毒疮疡。大黄炭凉血化瘀止血。用于血热有瘀出血症。【用法用量】内服：煎汤，3～30g。【注意】血虚气弱，脾胃虚寒，无实热、积滞、瘀结，以及胎前、产后，均应慎服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗急性胰腺炎的中药，通过选择合适的药材及其配比，达到安全有效治愈急性胰腺炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗湿疹急性胰腺炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏l0份，熟大黄6份，红枣15份，生姜3份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院急性胰腺炎患者61例，随机分为治疗组32例与对照组29例，治疗组男24例，女8例，年龄3～45岁， 平均年龄38.6岁；对照组男22例，女7例，平均年龄38.8岁。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国急性胰腺炎临床专业会议的诊断标准：(1)、急性胰腺炎临床表现为急性持续性腹痛(偶无腹痛)，血淀粉酶活性增高≥正常上限3倍。影像学提示胰腺有或无形态改变；排除其它疾患，可有或无其它器官功能障碍；少数病例血清淀粉酶活性正常或轻度增高；(2)、轻症急性胰腺炎：具备急性胰腺炎的临床表现和生化变化，而无器官功能障碍或局部并发症。对液体补充治疗反应良好。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日2次。疗程14天。
对照组口服甲硝唑、喹诺酮类抗生素(按说明书服用)，疗程14天。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：3d内症状、体征缓解，7d内消失，血、尿淀粉酶正常。
显效：d内症状、体征显著好转，血、尿淀粉酶恢复正常；
有效：7d内症状、体征减轻，血、尿淀粉酶有下降趋势；
无效：7d内症状体征未减轻或恶化，血、尿淀粉酶未降低；
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017103553-appb-000001
可见，本发明制得的药物能够安全有效治疗急性胰腺炎，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：柴胡15克，枳壳10克，枳实10克，黄芩10克，白芍12克，法半夏l0克，熟大黄6克，红枣15克，生姜3克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗急性胰腺炎。口服，每日分早晚两次服用。
实施例2
称取：柴胡15克，枳壳10克，枳实10克，黄芩10克，白芍12克，法半夏l0克，熟大黄6克，红枣15克，生姜3克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗急性胰腺炎。口服，每日分早晚两次服用。
实施例3
称取：柴胡15克，枳壳10克，枳实10克，黄芩10克，白芍12克，法半夏l0克，熟大黄6克，红枣15克，生姜3克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗急性胰腺炎。口服，每日分早晚两次服用。

Claims (4)

  1. 一种用于治疗急性胰腺炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏l0份，熟大黄6份，红枣15份，生姜3份。
  2. 如权利要求1所述的用于急性胰腺炎的中药，其特征在于，其制备方法为：称取：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏l0份，熟大黄6份，红枣15份，生姜3份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗急性胰腺炎的中药，其特征在于，其制备方法为：称取：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏l0份，熟大黄6份，红枣15份，生姜3份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗急性胰腺炎的中药，其特征在于，其制备方法为：称取：柴胡15份，枳壳10份，枳实10份，黄芩10份，白芍12份，法半夏l0份，熟大黄6份，红枣15份，生姜3份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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