WO2019014958A1 - Biological sample collecting and processing bottle, and method of use therefor - Google Patents
Biological sample collecting and processing bottle, and method of use therefor Download PDFInfo
- Publication number
- WO2019014958A1 WO2019014958A1 PCT/CN2017/094570 CN2017094570W WO2019014958A1 WO 2019014958 A1 WO2019014958 A1 WO 2019014958A1 CN 2017094570 W CN2017094570 W CN 2017094570W WO 2019014958 A1 WO2019014958 A1 WO 2019014958A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bottle
- treatment
- biological sample
- sample
- sample collection
- Prior art date
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
Definitions
- the invention relates to the field of manufacturing biological sample collection and treatment bottles, in particular to a biological sample collection and treatment bottle and a using method thereof.
- the invention aims at the above problems, and proposes a biological sample collection and processing bottle, which solves the defects that the existing biological sample collection and treatment bottle is easy to be infected, has a single function, and has a poor work experience.
- a biological sample collection and processing bottle comprises: a bottle body for storing a built-in sample processing liquid; an opening at the bottom of the bottle mouth; a positioning rib on a lower side wall of the bottle body; and a retractable pipe body assembly, Disposed on the upper part of the bottle body and fixedly connected to the bottle body; the bottle mouth is disposed on the upper part of the pipe body assembly and fixedly connected to the pipe body assembly; the inner side wall of the bottle mouth is fixed with a flange; the inner cover is set inside the bottle mouth; the inner cover Slidably contacting the flange; the mouth area of the upper part of the inner cover is a sample storage cavity; the head, the upper part abuts the inner cover; the bottom of the head is fixed on the positioning rib of the bottle body; the tube body assembly is used for the longitudinal direction Stretching or contracting, the tubular body is contracted such that the head lifts up the inner lid; the outer lid and the outer lid are at the mouth of the bottle, and the outer lid is used to seal the mouth of the bottle
- the invention adopts an inner cover, a head and a retractable pipe body assembly to contract the pipe body assembly, the inner head will jack up the inner cover, and the bottle body is opened; then after the collection bottle is inverted, the treatment liquid will flow out of the cavity, and the raw The sample is mixed, and then the tube assembly is forwardly contracted, so that the mixed treatment liquid is dripped through the opening of the bottom, and the biological sample can be directly collected in the closed container without the need for secondary opening, without using additional experimental instruments.
- the pre-treatment and transfer of the sample can be completed in a few simple steps on the collector, which can greatly reduce the risk of contamination of the experimenter and the sample, and can improve the working experience of the sample preparation and simplify the experimental operation. , saving experiment time and cost.
- a lower portion of the bottle body is provided with a wrench block, and the wrench block is located at two sides of the bottle body.
- the upper portion of the bottle body has a convex protrusion.
- the biological sample collection processing bottle further includes a safety buckle having at least one pair of longitudinally juxtaposed clamping blocks and a connecting portion connecting the pair of the clamping blocks, the top of the clamping block abutting Hold the bump and the lower part against the wrench.
- the safety buckle is used to effectively avoid the defect of dripping the treatment liquid by mistake in the taking process.
- the tubular body assembly adopts a tubular body in which the foldable corrugated sheets are connected in a folding and contracting direction.
- the tubular body connected by the foldable crepe sheet similar to the organ structure in the direction of folding and contracting has the following three functions: longitudinally telescopic ejection of the inner cover; longitudinal stretching or contraction to release the treated liquid; deformation of the range to control the extruded liquid It is quantitative.
- the plug is composed of three support blocks, and an angle between any two support blocks is 120°.
- the bottom of the support block has a convex engaging portion
- the bottom of the engaging portion has a card slot
- the card slot extends laterally to a sidewall of a vertical direction of the engaging portion, and the card slot is used for a card slot. Live positioning ribs.
- the biological sample collection processing bottle further includes an outlet cover, the outlet cover outer sleeve is outside the opening, and the outlet cover is threadedly engaged with the opening.
- the upper surface of the outer cover has a transparent area.
- the upper surface of the inner cover further has an outwardly protruding annular card edge.
- the annular card edge is used to collect the sample.
- the invention also discloses a method for using a biological sample collection and processing bottle, comprising the following steps:
- a) collecting samples the user opens the outer cover and collects the biological sample in a closed container;
- the liquid is sealed in the biological sample collection and treatment bottle; the treatment liquid is released from the closed environment by other physical or chemical means such as extrusion or pushing;
- step b) mixing of the sample and the processing reagent can be performed without opening the processing bottle to complete the sample pretreatment.
- step c) the sample properties and the process can be observed without opening the treatment bottle.
- the pre-processed sample can be output in the step d) without an external tool.
- the invention has the beneficial effects that the invention adopts an inner cover, a plug and a retractable tubular body assembly, and the tubular body assembly is contracted, the inner head will lift the inner cover, the bottle body is opened; and then the collection bottle is inverted, the treatment liquid Will flow out of the cavity, mix with the biological sample, and then shrink the tube assembly forward, so that the mixed treatment liquid is dripped through the opening of the bottom, the pretreatment process of the entire sample is carried out in a sealed environment, (1) effective reduction experiment The probability of the person being infected by the pathogenic microorganism in the sample and the sample being contaminated; (2) the experimenter does not need to directly face the experimental sample, and the work experience is improved; (3) the experimental operation is simplified, and the sample can be directly transferred quantitatively after the treatment; (4) The pre-treatment and transfer process of the sample does not require additional laboratory equipment.
- the safety buckle is used to effectively avoid the defect that the handling solution is dripped out by the handling process.
- FIG. 1 is a schematic front view showing the structure of a biological sample collection and treatment bottle of the present invention
- FIG. 2 is a schematic cross-sectional structural view of a biological sample collection and treatment bottle before extrusion
- FIG. 3 is a schematic cross-sectional structural view of a biological sample collection and treatment bottle after extrusion
- FIG. 4 is a schematic structural view of a drip operation flow of a biological sample collection and treatment bottle.
- the invention discloses a biological sample collection and processing bottle (see FIGS. 1, 2, 3, 4), comprising: a bottle body 1 for storing the built-in sample processing liquid; the bottom of the bottle mouth 5 is provided with an opening 2; The lower side wall of the bottle body 1 is provided with a positioning rib 3; a retractable tube body assembly 4 is disposed on the upper part of the bottle body 1 and fixedly connected to the bottle body 1; the bottle mouth 5 is disposed on the upper part of the tube body assembly 4 and fixes the connecting tube The body assembly 4; the inner side wall of the bottle mouth 5 is fixed with a flange 6; the inner cover 7 is disposed inside the bottle mouth 5; the inner cover 7 slidably contacts the flange 6; the mouth of the upper part of the inner cover 7 The area 5 is the sample storage chamber 8; the head 9 has an upper portion against the inner cover 7; the head 9 The bottom is fixed on the positioning rib 3 of the bottle body 1; the tube body assembly 4 is used for longitudinal stretching or contraction, the tube body is contracted to cause the head 9
- the invention adopts an inner cover 7, a head 9 and a telescopic tube assembly 4 to contract the tube assembly 4, the inner head 8 will lift the inner cover, and the bottle body is opened; then, after the collection bottle is inverted, the treatment liquid will flow out.
- the cavity is mixed with the biological sample, and then the tube assembly is forwardly contracted, so that the mixed treatment liquid is dripped through the opening of the bottom, and the pretreatment process of the entire sample is performed in a sealed environment, (1) effectively reducing the experimenter's being The probability of pathogenic microbial infection and sample contamination in the sample; (2) the experimenter does not need to directly face the experimental sample, the work experience can be improved; (3) the experimental operation is simplified, and the sample can be directly transferred quantitatively after treatment; (4) the sample Pre-treatment and transfer processes without additional laboratory equipment.
- the retractable pipe assembly of the present invention can also adopt a piston structure; the sealing of the treatment liquid is changed from the inner cover 7 to the bubble structure (the treatment liquid is sealed in the bubble environment) or the heat sealing film is sealed (the inner cover is changed to the sealing film) .
- the lower part of the bottle body 1 is provided with a wrench block 12, and the wrench block 12 is located on both sides of the bottle body 1.
- the upper portion of the bottle body 1 has convex protrusions 13.
- the biological sample collection treatment bottle further includes a safety buckle 14 having at least one pair of longitudinally juxtaposed clamps 15 and a connection portion 16 connecting a pair of the clamp blocks 15, the clamp block 15 The top is against the bump 13 and the lower part is against the wrench 12.
- the safety buckle 14 is adopted to effectively avoid the defect that the handling liquid is dripped out by the handling process.
- the tubular body assembly 4 is a tubular body in which the foldable corrugated sheets 21 are joined in a folding and contracting direction.
- the tubular body connected by the foldable crepe sheet 21 similar to the organ structure in the direction of folding and contracting has the following three functions: longitudinally stretching and ejecting the inner cover 7; longitudinally stretching or contracting to release the treated liquid; and the range-controlled extrusion of the deformation
- the liquid is quantitative.
- the plug 9 is composed of three support blocks 18, and the angle between any two support blocks 18 is 120°.
- the bottom of the support block 18 has a convex engaging portion 19, and the bottom of the engaging portion 19 has a card slot 20 extending laterally to the vertical side wall of the engaging portion 19, the card slot 20 Used to clamp the positioning rib 3.
- the biological sample collection treatment bottle further includes an outlet cover 11 that is jacketed outside the opening 2, and the outlet cover 11 is threadedly engaged with the opening 2.
- the upper surface of the outer cover 10 has a transparent area 22 for observing the inner sample.
- the inner surface of the inner cover 7 further has an outwardly protruding annular card edge 23.
- the annular card edge 23 is used to collect the sample.
- the invention also discloses a method for using a biological sample collection and processing bottle, comprising the following steps:
- a) collecting samples the user opens the outer cover and collects the biological sample in a closed container;
- the liquid is sealed in the biological sample collection and treatment bottle; the treatment liquid is released from the closed environment by other physical or chemical means such as extrusion or pushing;
- the sample and the processing reagent can be mixed without opening the treatment bottle to complete the sample pretreatment.
- the sample properties and the treatment process can be observed without opening the treatment bottle.
- the pre-processed sample can be output in the step d) without an external tool.
- the user unscrews the outer cover to bring the biological sample into the collection bottle and tightens the bottle cap.
- the safety buckle is pulled open, the wrench is fastened by hand and the cover of the collection bottle is pressed, the telescopic tube assembly is contracted, and the inner head pushes up the inner cover to open the cavity of the treatment liquid;
- the treatment liquid will flow out of the cavity and mix with the biological sample; after being placed for a certain period of time, the experimenter can unscrew the outlet cover counterclockwise and press the collection bottle cap.
- the retractable tube assembly structure of the present invention Quantitative deformation will occur again, eventually extruding a standard amount of treated sample.
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Disclosed is a biological sample collecting and processing bottle, comprising: a bottle body (1) for storing an in-built sample processing liquid, wherein an opening (2) is provided in the bottom of a bottleneck, and a positioning rib (3) is arranged on a lower side wall of the bottle body; a retractable pipe assembly (4) arranged on an upper part of the bottle body and fixedly connected to the bottle body, wherein the bottleneck (5) is arranged on an upper part of the pipe assembly, a flange (6) is fixed on an inner side wall of the bottleneck, an inner cap (7) is arranged in the bottleneck, the inner cap is in contact with the flange in a slidable manner, and the bottleneck zone above the inner cap is a sample storage cavity (8); an ejector head (9) with an upper part being abutted against the inner cap, the ejector head being fixed to the positioning rib of the bottle body; and an outer cap (10) arranged at the bottleneck and used for sealing the bottleneck. The inner cap, the ejector head and the retractable pipe assembly are used in the processing bottle, effectively reducing the probability of an experimenter being infected by pathogenic microorganisms in the sample and the probability of sample contamination. The experimenter does not need to directly face the experimental sample so that working experience is improved. The experiment operation is simplified, the processed sample can be directly quantitatively transferred, and the pretreatment and transferring processes of the sample do not require extra experiment instruments.
Description
本发明涉及生物样本收集处理瓶制造领域,具体涉及一种生物样本收集处理瓶及其使用方法。The invention relates to the field of manufacturing biological sample collection and treatment bottles, in particular to a biological sample collection and treatment bottle and a using method thereof.
现有的生物样本(比如唾液、痰液、尿液和粪便等)是收集在一个适当大小的空瓶中。由实验人员准备相应处理液及移液器具,手动打开瓶子,并往瓶子中注入相应处理液,放置一定时间后再通过移液器具来转移处理后的样本。主要缺陷在于:1)实验人员需要打开收集瓶后才能完成生物样本的处理和转移,瓶子打开和操作过程中会形成气溶胶,实验人员存在被传染的风险;2)实验人员需要打开收集瓶才能完成生物样本的处理和转移,增加了样本被污染的风险;3)实验人员在处理样本时,需打开收集瓶盖,直接面对原始生物样本,工作体验较差;4)不包含样本处理液,需要操作人员准备移液器具和处理液,然后添加处理液至收集瓶,需要较多操作步骤、时间及成本;5)需要操作人员准备移液器具,打开收集瓶盖来转移处理后的样本,需要较多操作步骤、时间及成本;6)实验人员在处理痰液样本时,需要转移高pH值处理液,存在烧伤风险。Existing biological samples (such as saliva, sputum, urine, and feces) are collected in an empty bottle of appropriate size. The experimenter prepares the corresponding treatment liquid and pipetting device, manually opens the bottle, and injects the corresponding treatment liquid into the bottle, and after a certain period of time, transfers the processed sample through the pipetting device. The main drawbacks are: 1) The experimenter needs to open the collection bottle to complete the processing and transfer of the biological sample. The aerosol will form during the bottle opening and operation, and the experimenter will be infected. 2) The experimenter needs to open the collection bottle. Complete the processing and transfer of biological samples, increasing the risk of contamination of the sample; 3) When the sample is processed, the experimenter needs to open the collection cap and directly face the original biological sample, which has a poor working experience; 4) Does not contain the sample treatment solution The operator needs to prepare the pipetting device and the treatment liquid, and then add the treatment liquid to the collection bottle, which requires more steps, time and cost; 5) the operator needs to prepare the pipetting device, and the collection bottle cap is opened to transfer the processed sample. It requires more steps, time and cost; 6) When the laboratory personnel are handling the sputum sample, it is necessary to transfer the high pH treatment solution, which poses a risk of burns.
发明内容Summary of the invention
本发明针对上述问题,提出了一种生物样本收集处理瓶,解决了现有的生物样本收集处理瓶的容易发生传染、功能单一、工作体验差的缺陷。The invention aims at the above problems, and proposes a biological sample collection and processing bottle, which solves the defects that the existing biological sample collection and treatment bottle is easy to be infected, has a single function, and has a poor work experience.
本发明采取的技术方案如下:The technical solution adopted by the present invention is as follows:
一种生物样本收集处理瓶,包括:瓶体,用于储存内置的样本处理液;所述瓶口底部设有开口;所述瓶体下部侧壁设有定位筋;可伸缩的管体组件,设置在瓶体上部并固定连接瓶体;瓶口,设置在管体组件上部并固定连接管体组件;所述瓶口的内侧壁上固定凸缘;内盖,设置瓶口内;所述内盖可滑动地接触凸缘;所述内盖上部的瓶口区域为样本储存腔;顶头,上部抵住内盖;所述顶头底部固定在瓶体的定位筋上;所述管体组件用于纵向伸展或收缩,所述管体收缩时使得顶头顶起内盖;外盖,外盖在瓶口处,所述外盖用于密封瓶口。A biological sample collection and processing bottle comprises: a bottle body for storing a built-in sample processing liquid; an opening at the bottom of the bottle mouth; a positioning rib on a lower side wall of the bottle body; and a retractable pipe body assembly, Disposed on the upper part of the bottle body and fixedly connected to the bottle body; the bottle mouth is disposed on the upper part of the pipe body assembly and fixedly connected to the pipe body assembly; the inner side wall of the bottle mouth is fixed with a flange; the inner cover is set inside the bottle mouth; the inner cover Slidably contacting the flange; the mouth area of the upper part of the inner cover is a sample storage cavity; the head, the upper part abuts the inner cover; the bottom of the head is fixed on the positioning rib of the bottle body; the tube body assembly is used for the longitudinal direction Stretching or contracting, the tubular body is contracted such that the head lifts up the inner lid; the outer lid and the outer lid are at the mouth of the bottle, and the outer lid is used to seal the mouth of the bottle.
本发明采用内盖、顶头以及可伸缩的管体组件,将管体组件收缩,内部的顶头会将内盖顶起,瓶体打开;然后倒置收集瓶后,处理液会流出腔体,与生
物样本混合,然后正向收缩管体组件,使得混合后处理液通过底部的开口滴出,可将生物样本直接收集于封闭容器中,无需二次开盖,无需用到额外的实验器具,通过收集器上几步简单的操作便可完成样本的前处理及转移,既可以极大的降低实验人员被传染及样本被污染的风险,也可以改善样本前处理的工作体验,同时简化了实验操作,节省了实验时间及成本。The invention adopts an inner cover, a head and a retractable pipe body assembly to contract the pipe body assembly, the inner head will jack up the inner cover, and the bottle body is opened; then after the collection bottle is inverted, the treatment liquid will flow out of the cavity, and the raw
The sample is mixed, and then the tube assembly is forwardly contracted, so that the mixed treatment liquid is dripped through the opening of the bottom, and the biological sample can be directly collected in the closed container without the need for secondary opening, without using additional experimental instruments. The pre-treatment and transfer of the sample can be completed in a few simple steps on the collector, which can greatly reduce the risk of contamination of the experimenter and the sample, and can improve the working experience of the sample preparation and simplify the experimental operation. , saving experiment time and cost.
可选的,所述瓶体下部设有扳块,所述扳块位于瓶体两侧。Optionally, a lower portion of the bottle body is provided with a wrench block, and the wrench block is located at two sides of the bottle body.
可选的,所述瓶体上部具有外凸的凸块。Optionally, the upper portion of the bottle body has a convex protrusion.
可选的,所述生物样本收集处理瓶还包括安全卡扣,所述安全卡扣具有至少一对纵向并列的夹块和连接一对所述的夹块的连接部,所述夹块顶部抵住凸块,下部抵住扳块。采用安全卡扣,有效避免拿取过程误操作滴出处理液的缺陷。Optionally, the biological sample collection processing bottle further includes a safety buckle having at least one pair of longitudinally juxtaposed clamping blocks and a connecting portion connecting the pair of the clamping blocks, the top of the clamping block abutting Hold the bump and the lower part against the wrench. The safety buckle is used to effectively avoid the defect of dripping the treatment liquid by mistake in the taking process.
可选的,所述管体组件采用可折叠皱纹片沿折叠伸缩方向连接成的管体。采用类似于风琴结构的可折叠皱纹片沿折叠伸缩方向连接成的管体,具有以下三个作用:纵向伸缩顶出内盖;纵向伸展或收缩释放处理后液体;形变的量程控制挤出的液体是定量的。Optionally, the tubular body assembly adopts a tubular body in which the foldable corrugated sheets are connected in a folding and contracting direction. The tubular body connected by the foldable crepe sheet similar to the organ structure in the direction of folding and contracting has the following three functions: longitudinally telescopic ejection of the inner cover; longitudinal stretching or contraction to release the treated liquid; deformation of the range to control the extruded liquid It is quantitative.
可选的,所述顶头由三个支撑块组成,任意两个支撑块之间的夹角为120°。Optionally, the plug is composed of three support blocks, and an angle between any two support blocks is 120°.
可选的,所述支撑块底部具有外凸的卡合部,所述卡合部的底部具卡槽,所述卡槽横向延伸至卡合部垂直方向侧壁,所述卡槽用于卡住定位筋。Optionally, the bottom of the support block has a convex engaging portion, the bottom of the engaging portion has a card slot, and the card slot extends laterally to a sidewall of a vertical direction of the engaging portion, and the card slot is used for a card slot. Live positioning ribs.
可选的,所述生物样本收集处理瓶还包括出口盖,所述出口盖外套在开口外侧,所述出口盖与开口螺纹配合。Optionally, the biological sample collection processing bottle further includes an outlet cover, the outlet cover outer sleeve is outside the opening, and the outlet cover is threadedly engaged with the opening.
可选的,所述外盖上表面具有透明区域。Optionally, the upper surface of the outer cover has a transparent area.
可选的,所述内盖上表面上还具有向外凸出的环形卡缘。环形卡缘用于集聚样品。Optionally, the upper surface of the inner cover further has an outwardly protruding annular card edge. The annular card edge is used to collect the sample.
本发明还公开了一种生物样本收集处理瓶的使用方法,包括以下步骤:The invention also discloses a method for using a biological sample collection and processing bottle, comprising the following steps:
a)收集样品:使用者打开外盖,收集生物样本于封闭容器中;a) collecting samples: the user opens the outer cover and collects the biological sample in a closed container;
b)样本的前处理:处理液密闭预装在生物样本收集处理瓶中;采用挤压或推助等其他物理或化学方式将处理液从密闭环境中释放;b) pre-treatment of the sample: the liquid is sealed in the biological sample collection and treatment bottle; the treatment liquid is released from the closed environment by other physical or chemical means such as extrusion or pushing;
c)样本前处理效果观察:如有需要可以肉眼可视的形式观察内部的样品的物理性状,用户有较好的用户体验;c) Observation of the effect of sample pretreatment: If necessary, the physical properties of the internal sample can be observed by the naked eye, and the user has a good user experience;
d)样本的转移:打开出口盖,采用挤压或推助的方式输出处理后液体;因进行过样本前处理,样本中病原微生物被杀死,处理后的液体的释放降低污染环境及感染操作者的风险。
d) Transfer of the sample: open the outlet cover and output the treated liquid by extrusion or push-up; the pathogenic microorganisms in the sample are killed due to the pre-sample treatment, and the release of the treated liquid reduces the pollution environment and infection operation. Risk.
可选的,所述步骤b)中无需打开处理瓶即可进行样本与处理试剂的混合进而完成样本前处理。Optionally, in step b), mixing of the sample and the processing reagent can be performed without opening the processing bottle to complete the sample pretreatment.
可选的,所述步骤c)中无需打开处理瓶即可观察样本性状及处理过程。Optionally, in step c), the sample properties and the process can be observed without opening the treatment bottle.
可选的,所述步骤d)中无需外部工具即可输出经过前处理的样本。Optionally, the pre-processed sample can be output in the step d) without an external tool.
本发明的有益效果是:本发明采用内盖、顶头以及可伸缩的管体组件,将管体组件收缩,内部的顶头会将内盖顶起,瓶体打开;然后倒置收集瓶后,处理液会流出腔体,与生物样本混合,然后正向收缩管体组件,使得混合后处理液通过底部的开口滴出,整个样本的前处理过程均在密封环境中进行,(1)有效的降低实验人员被样本中病原微生物感染及样本被污染的机率;(2)实验人员无需直接面对实验样本,工作体验得以改善;(3)简化了实验操作,处理后样本可直接定量转移;(4)样本的前处理和转移过程,无需额外的实验器材。The invention has the beneficial effects that the invention adopts an inner cover, a plug and a retractable tubular body assembly, and the tubular body assembly is contracted, the inner head will lift the inner cover, the bottle body is opened; and then the collection bottle is inverted, the treatment liquid Will flow out of the cavity, mix with the biological sample, and then shrink the tube assembly forward, so that the mixed treatment liquid is dripped through the opening of the bottom, the pretreatment process of the entire sample is carried out in a sealed environment, (1) effective reduction experiment The probability of the person being infected by the pathogenic microorganism in the sample and the sample being contaminated; (2) the experimenter does not need to directly face the experimental sample, and the work experience is improved; (3) the experimental operation is simplified, and the sample can be directly transferred quantitatively after the treatment; (4) The pre-treatment and transfer process of the sample does not require additional laboratory equipment.
另外,采用安全卡扣,有效避免拿取过程误操作滴出处理液的缺陷。In addition, the safety buckle is used to effectively avoid the defect that the handling solution is dripped out by the handling process.
图1是本发明生物样本收集处理瓶的主视结构示意图;1 is a schematic front view showing the structure of a biological sample collection and treatment bottle of the present invention;
图2是生物样本收集处理瓶的挤压前剖面结构示意图;2 is a schematic cross-sectional structural view of a biological sample collection and treatment bottle before extrusion;
图3是生物样本收集处理瓶的挤压后剖面结构示意图;3 is a schematic cross-sectional structural view of a biological sample collection and treatment bottle after extrusion;
图4是生物样本收集处理瓶的滴液操作流程结构示意图。4 is a schematic structural view of a drip operation flow of a biological sample collection and treatment bottle.
图中各附图标记为:The reference numerals in the figure are:
1、瓶体;2、开口;3、定位筋;4、管体组件;5、瓶口;6、凸缘;7、内盖;8、样本储存腔;9、顶头;10、外盖;11、出口盖;12、扳块;13、凸块;14、安全卡扣;15、夹块;16、连接部;18、支撑块;19、卡合部;20、卡槽;21、皱纹片;22、透明区域;23、环形卡缘;a、处理液的存放位置。1, bottle body; 2, opening; 3, positioning ribs; 4, pipe body components; 5, bottle mouth; 6, flange; 7, inner cover; 8, sample storage cavity; 9, head; 10, outer cover; 11. Exit cover; 12, wrench block; 13, bump; 14, safety buckle; 15, clamp block; 16, connecting portion; 18, support block; 19, engaging portion; 20, card slot; Sheet; 22, transparent area; 23, annular card edge; a, storage location of the treatment liquid.
下面结合各附图,对本发明做详细描述。The invention will now be described in detail in conjunction with the drawings.
本发明公开了一种生物样本收集处理瓶(见附图1、2、3、4),包括:瓶体1,用于储存内置的样本处理液;所述瓶口5底部设有开口2;所述瓶体1下部侧壁设有定位筋3;可伸缩的管体组件4,设置在瓶体1上部并固定连接瓶体1;瓶口5,设置在管体组件4上部并固定连接管体组件4;所述瓶口5的内侧壁上固定凸缘6;内盖7,设置瓶口5内;所述内盖7可滑动地接触凸缘6;所述内盖7上部的瓶口5区域为样本储存腔8;顶头9,上部抵住内盖7;所述顶头9
底部固定在瓶体1的定位筋3上;所述管体组件4用于纵向伸展或收缩,所述管体收缩时使得顶头9顶起内盖7;外盖10,外盖10在瓶口5处,所述外盖10用于密封瓶口5。The invention discloses a biological sample collection and processing bottle (see FIGS. 1, 2, 3, 4), comprising: a bottle body 1 for storing the built-in sample processing liquid; the bottom of the bottle mouth 5 is provided with an opening 2; The lower side wall of the bottle body 1 is provided with a positioning rib 3; a retractable tube body assembly 4 is disposed on the upper part of the bottle body 1 and fixedly connected to the bottle body 1; the bottle mouth 5 is disposed on the upper part of the tube body assembly 4 and fixes the connecting tube The body assembly 4; the inner side wall of the bottle mouth 5 is fixed with a flange 6; the inner cover 7 is disposed inside the bottle mouth 5; the inner cover 7 slidably contacts the flange 6; the mouth of the upper part of the inner cover 7 The area 5 is the sample storage chamber 8; the head 9 has an upper portion against the inner cover 7; the head 9
The bottom is fixed on the positioning rib 3 of the bottle body 1; the tube body assembly 4 is used for longitudinal stretching or contraction, the tube body is contracted to cause the head 9 to lift up the inner cover 7; the outer cover 10, the outer cover 10 is at the mouth of the bottle At 5, the outer cover 10 is used to seal the bottle opening 5.
本发明采用内盖7、顶头9以及可伸缩的管体组件4,将管体组件4收缩,内部的顶头8会将内盖顶起,瓶体打开;然后倒置收集瓶后,处理液会流出腔体,与生物样本混合,然后正向收缩管体组件,使得混合后处理液通过底部的开口滴出,整个样本的前处理过程均在密封环境中进行,(1)有效的降低实验人员被样本中病原微生物感染及样本被污染的机率;(2)实验人员无需直接面对实验样本,工作体验得以改善;(3)简化了实验操作,处理后样本可直接定量转移;(4)样本的前处理和转移过程,无需额外的实验器材。The invention adopts an inner cover 7, a head 9 and a telescopic tube assembly 4 to contract the tube assembly 4, the inner head 8 will lift the inner cover, and the bottle body is opened; then, after the collection bottle is inverted, the treatment liquid will flow out. The cavity is mixed with the biological sample, and then the tube assembly is forwardly contracted, so that the mixed treatment liquid is dripped through the opening of the bottom, and the pretreatment process of the entire sample is performed in a sealed environment, (1) effectively reducing the experimenter's being The probability of pathogenic microbial infection and sample contamination in the sample; (2) the experimenter does not need to directly face the experimental sample, the work experience can be improved; (3) the experimental operation is simplified, and the sample can be directly transferred quantitatively after treatment; (4) the sample Pre-treatment and transfer processes without additional laboratory equipment.
本发明的可伸缩的管体组件还可采用活塞结构;处理液的密封由内盖7密封改为液泡结构(处理液密封在液泡环境中)或热封膜密闭(内盖改为封膜)。The retractable pipe assembly of the present invention can also adopt a piston structure; the sealing of the treatment liquid is changed from the inner cover 7 to the bubble structure (the treatment liquid is sealed in the bubble environment) or the heat sealing film is sealed (the inner cover is changed to the sealing film) .
所述瓶体1下部设有扳块12,所述扳块12位于瓶体1两侧。所述瓶体1上部均有外凸的凸块13。所述生物样本收集处理瓶还包括安全卡扣14,所述安全卡扣14具有至少一对纵向并列的夹块15和连接一对所述的夹块15的连接部16,所述夹块15顶部抵住凸块13,下部抵住扳块12。采用安全卡扣14,有效避免拿取过程误操作滴出处理液的缺陷。The lower part of the bottle body 1 is provided with a wrench block 12, and the wrench block 12 is located on both sides of the bottle body 1. The upper portion of the bottle body 1 has convex protrusions 13. The biological sample collection treatment bottle further includes a safety buckle 14 having at least one pair of longitudinally juxtaposed clamps 15 and a connection portion 16 connecting a pair of the clamp blocks 15, the clamp block 15 The top is against the bump 13 and the lower part is against the wrench 12. The safety buckle 14 is adopted to effectively avoid the defect that the handling liquid is dripped out by the handling process.
所述管体组件4采用可折叠皱纹片21沿折叠伸缩方向连接成的管体。采用类似于风琴结构的可折叠皱纹片21沿折叠伸缩方向连接成的管体,具有以下三个作用:纵向伸缩顶出内盖7;纵向伸展或收缩释放处理后液体;形变的量程控制挤出的液体是定量的。The tubular body assembly 4 is a tubular body in which the foldable corrugated sheets 21 are joined in a folding and contracting direction. The tubular body connected by the foldable crepe sheet 21 similar to the organ structure in the direction of folding and contracting has the following three functions: longitudinally stretching and ejecting the inner cover 7; longitudinally stretching or contracting to release the treated liquid; and the range-controlled extrusion of the deformation The liquid is quantitative.
所述顶头9由三个支撑块18组成,任意两个支撑块18之间的夹角为120°。所述支撑块18底部具有外凸的卡合部19,所述卡合部19的底部具卡槽20,所述卡槽20横向延伸至卡合部19垂直方向侧壁,所述卡槽20用于卡住定位筋3。所述生物样本收集处理瓶还包括出口盖11,所述出口盖11外套在开口2外侧,所述出口盖11与开口2螺纹配合。The plug 9 is composed of three support blocks 18, and the angle between any two support blocks 18 is 120°. The bottom of the support block 18 has a convex engaging portion 19, and the bottom of the engaging portion 19 has a card slot 20 extending laterally to the vertical side wall of the engaging portion 19, the card slot 20 Used to clamp the positioning rib 3. The biological sample collection treatment bottle further includes an outlet cover 11 that is jacketed outside the opening 2, and the outlet cover 11 is threadedly engaged with the opening 2.
所述外盖10上表面具有透明区域22,所述透明区域22用于观察内部的样品。所述内盖7上表面上还具有向外凸出的环形卡缘23。环形卡缘23用于集聚样品。The upper surface of the outer cover 10 has a transparent area 22 for observing the inner sample. The inner surface of the inner cover 7 further has an outwardly protruding annular card edge 23. The annular card edge 23 is used to collect the sample.
本发明还公开了一种生物样本收集处理瓶的使用方法,包括以下步骤:The invention also discloses a method for using a biological sample collection and processing bottle, comprising the following steps:
a)收集样品:使用者打开外盖,收集生物样本于封闭容器中;
a) collecting samples: the user opens the outer cover and collects the biological sample in a closed container;
b)样本的前处理:处理液密闭预装在生物样本收集处理瓶中;采用挤压或推助等其他物理或化学方式将处理液从密闭环境中释放;b) pre-treatment of the sample: the liquid is sealed in the biological sample collection and treatment bottle; the treatment liquid is released from the closed environment by other physical or chemical means such as extrusion or pushing;
c)样本前处理效果观察:如有需要可以肉眼可视的形式观察内部的样品的物理性状,用户有较好的用户体验;c) Observation of the effect of sample pretreatment: If necessary, the physical properties of the internal sample can be observed by the naked eye, and the user has a good user experience;
d)样本的转移:打开出口盖,采用挤压或推助的方式输出处理后液体;因进行过样本前处理,样本中病原微生物被杀死,处理后的液体的释放降低污染环境及感染操作者的风险。d) Transfer of the sample: open the outlet cover and output the treated liquid by extrusion or push-up; the pathogenic microorganisms in the sample are killed due to the pre-sample treatment, and the release of the treated liquid reduces the pollution environment and infection operation. Risk.
所述步骤b)中无需打开处理瓶即可进行样本与处理试剂的混合进而完成样本前处理。所述步骤c)中无需打开处理瓶即可观察样本性状及处理过程。所述步骤d)中无需外部工具即可输出经过前处理的样本。In the step b), the sample and the processing reagent can be mixed without opening the treatment bottle to complete the sample pretreatment. In step c), the sample properties and the treatment process can be observed without opening the treatment bottle. The pre-processed sample can be output in the step d) without an external tool.
本发明实施时,使用者旋开外盖,使生物样本进入收集瓶后,旋紧瓶盖。实验人员操作时,拉开安全卡扣,用手扣住扳块并按压收集瓶外盖,可伸缩的管体组件收缩,内部的顶头会将内盖顶起,使处理液的腔体打开;倒置收集瓶后,处理液会流出腔体,与生物样本混合;放置一定时间后,实验人员可以逆时针旋开出口盖,按压收集瓶瓶盖,此时本发明中可伸缩的管体组件结构会再次发生定量形变,最终挤出标准量的处理后样本。In the practice of the present invention, the user unscrews the outer cover to bring the biological sample into the collection bottle and tightens the bottle cap. When the experimenter operates, the safety buckle is pulled open, the wrench is fastened by hand and the cover of the collection bottle is pressed, the telescopic tube assembly is contracted, and the inner head pushes up the inner cover to open the cavity of the treatment liquid; After inverting the collection bottle, the treatment liquid will flow out of the cavity and mix with the biological sample; after being placed for a certain period of time, the experimenter can unscrew the outlet cover counterclockwise and press the collection bottle cap. At this time, the retractable tube assembly structure of the present invention Quantitative deformation will occur again, eventually extruding a standard amount of treated sample.
以上所述仅为本发明的优选实施例,并非因此即限制本发明的专利保护范围,凡是运用本发明说明书及附图内容所作的等效结构变换,直接或间接运用在其他相关的技术领域,均同理包括在本发明的保护范围内。
The above description is only a preferred embodiment of the present invention, and thus does not limit the scope of patent protection of the present invention. Any equivalent structural transformation made by using the specification and the drawings of the present invention is directly or indirectly applied to other related technical fields. The same is included in the scope of protection of the present invention.
Claims (14)
- 一种生物样本收集处理瓶,其特征在于,包括:A biological sample collection and treatment bottle, comprising:瓶体,用于储存内置的样本处理液;所述瓶口底部设有开口;所述瓶体下部侧壁设有定位筋;a bottle body for storing the built-in sample processing liquid; the bottom of the bottle mouth is provided with an opening; and a sidewall of the lower part of the bottle body is provided with a positioning rib;可伸缩的管体组件,设置在瓶体上部并固定连接瓶体;a retractable tubular body assembly disposed on the upper portion of the bottle body and fixedly connected to the bottle body;瓶口,设置在管体组件上部并固定连接管体组件;所述瓶口的内侧壁上固定凸缘;a bottle mouth, disposed at an upper portion of the pipe body assembly and fixedly connecting the pipe body assembly; fixing a flange on an inner side wall of the bottle mouth;内盖,设置瓶口内;所述内盖可滑动地接触凸缘;所述内盖上部的瓶口区域为样本储存腔;The inner cover is disposed in the bottle mouth; the inner cover slidably contacts the flange; the bottle mouth area on the upper portion of the inner cover is a sample storage cavity;顶头,上部抵住内盖;所述顶头底部固定在瓶体的定位筋上;所述管体组件用于纵向伸展或收缩,所述管体收缩时使得顶头顶起内盖;a head, an upper part abuts against the inner cover; the bottom of the head is fixed on the positioning rib of the bottle body; the tube body assembly is used for longitudinal extension or contraction, and the tube body is contracted to cause the head to lift the inner cover;外盖,外盖在瓶口处,所述外盖用于密封瓶口。The outer cover is at the mouth of the bottle, and the outer cover is used to seal the bottle mouth.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述瓶体下部设有扳块,所述扳块位于瓶体两侧。The biological sample collection and treatment bottle according to claim 1, wherein a lower portion of the bottle body is provided with a wrench block, and the wrench block is located at two sides of the bottle body.
- 如权利要求2所述的生物样本收集处理瓶,其特征在于,所述瓶体上部具有外凸的凸块。The biological sample collection processing bottle according to claim 2, wherein the upper portion of the bottle body has a convex projection.
- 如权利要求3所述的生物样本收集处理瓶,其特征在于,还包括安全卡扣,所述安全卡扣具有至少一对纵向并列的夹块和连接一对所述的夹块的连接部,所述夹块顶部抵住凸块,下部抵住扳块。The biological sample collection processing bottle according to claim 3, further comprising a safety buckle having at least one pair of longitudinally juxtaposed clips and a connecting portion connecting the pair of the clips, The top of the clamp abuts the bump and the lower part abuts the wrench.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述管体组件采用可折叠皱纹片沿折叠伸缩方向连接成的管体。The biological sample collection and treatment bottle according to claim 1, wherein the tube assembly is a tube body in which the foldable crepe sheets are joined in a folding and contracting direction.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述顶头由三个支撑块组成,任意两个支撑块之间的夹角为120°。The biological sample collection processing bottle according to claim 1, wherein the plug is composed of three support blocks, and an angle between any two support blocks is 120°.
- 如权利要求6所述的生物样本收集处理瓶,其特征在于,所述支撑块底部具有外凸的卡合部,所述卡合部的底部具卡槽,所述卡槽横向延伸至卡合部垂直方向侧壁,所述卡槽用于卡住定位筋。The biological sample collection and treatment bottle according to claim 6, wherein the bottom of the support block has a convex engaging portion, and the bottom of the engaging portion has a card slot, and the card slot extends laterally to the engagement. The vertical direction side wall, the card slot is used to catch the positioning rib.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,还包括出口盖,所述出口盖外套在开口外侧,所述出口盖与开口螺纹配合。The biological sample collection treatment bottle according to claim 1, further comprising an outlet cover, the outlet cover outer casing being outside the opening, the outlet cover being threadedly engaged with the opening.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述外盖上表面具有透明区域。The biological sample collection processing bottle according to claim 1, wherein the upper surface of the outer cover has a transparent region.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述内盖上表面上还具有向外凸出的环形卡缘。 The biological sample collection and treatment bottle according to claim 1, wherein the upper surface of the inner cover further has an outwardly projecting annular card edge.
- 一种如权利要求1至10任意一项权利要求所述的生物样本收集处理瓶的使用方法,其特征在于,包括以下步骤:A method of using a biological sample collection and treatment bottle according to any one of claims 1 to 10, comprising the steps of:a)收集样品:使用者打开外盖,收集生物样本于封闭容器中;a) collecting samples: the user opens the outer cover and collects the biological sample in a closed container;b)样本的前处理:处理液密闭预装在生物样本收集处理瓶中;采用挤压或推助等其他物理或化学方式将处理液从密闭环境中释放;b) pre-treatment of the sample: the liquid is sealed in the biological sample collection and treatment bottle; the treatment liquid is released from the closed environment by other physical or chemical means such as extrusion or pushing;c)样本前处理效果观察:如有需要可以肉眼可视的形式观察内部的样品的物理性状,用户有较好的用户体验;c) Observation of the effect of sample pretreatment: If necessary, the physical properties of the internal sample can be observed by the naked eye, and the user has a good user experience;d)样本的转移:打开出口盖,采用挤压或推助的方式输出处理后液体;因进行过样本前处理,样本中病原微生物被杀死,处理后的液体的释放降低污染环境及感染操作者的风险。d) Transfer of the sample: open the outlet cover and output the treated liquid by extrusion or push-up; the pathogenic microorganisms in the sample are killed due to the pre-sample treatment, and the release of the treated liquid reduces the pollution environment and infection operation. Risk.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述步骤b)中无需打开处理瓶即可进行样本与处理试剂的混合进而完成样本前处理。The biological sample collection and treatment bottle according to claim 1, wherein in the step b), the sample and the treatment reagent are mixed without opening the treatment bottle to complete the sample preparation.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述步骤c)中无需打开处理瓶即可观察样本性状及处理过程。The biological sample collection and treatment bottle according to claim 1, wherein in the step c), the sample properties and the treatment process can be observed without opening the treatment bottle.
- 如权利要求1所述的生物样本收集处理瓶,其特征在于,所述步骤d)中无需外部工具即可输出经过前处理的样本。 The biological sample collection processing bottle according to claim 1, wherein said preprocessed sample is output without said external tool in said step d).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710586368.4A CN107202725B (en) | 2017-07-18 | 2017-07-18 | Biological specimen collection handles bottle and its application method |
CN201710586368.4 | 2017-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2019014958A1 true WO2019014958A1 (en) | 2019-01-24 |
Family
ID=59911856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2017/094570 WO2019014958A1 (en) | 2017-07-18 | 2017-07-26 | Biological sample collecting and processing bottle, and method of use therefor |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN107202725B (en) |
WO (1) | WO2019014958A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107937263A (en) * | 2017-11-23 | 2018-04-20 | 北京海普威生物技术有限公司 | Self-check system and method based on gene magnification |
CN107746803B (en) * | 2017-11-23 | 2020-12-11 | 北京海普威生物技术有限公司 | Gene detection system and method capable of realizing autonomous detection |
CN107828639B (en) * | 2017-11-23 | 2020-12-15 | 北京海普威生物技术有限公司 | Sample injector with pretreatment function and sample pretreatment and sample injection method |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001194365A (en) * | 1999-11-05 | 2001-07-19 | Sekisui Chem Co Ltd | Container and method for measuring cell function |
CN2800261Y (en) * | 2005-06-22 | 2006-07-26 | 常熟市矿山机电器材有限公司 | Dust sampling head |
CN200996897Y (en) * | 2006-09-15 | 2007-12-26 | 艾博生物医药(杭州)有限公司 | Sampler collecting container |
CN204142525U (en) * | 2014-10-29 | 2015-02-04 | 博奥生物集团有限公司 | A kind of micro liquid sampling sample adding device |
CN205843989U (en) * | 2016-08-05 | 2016-12-28 | 武汉康立优医疗发展有限公司 | Integral type secretions pretreatment unit |
EP3171152A1 (en) * | 2015-11-19 | 2017-05-24 | Miltenyi Biotec GmbH | Process and device for isolating cells from biological tissue |
CN207081595U (en) * | 2017-07-18 | 2018-03-09 | 杭州优思达生物技术有限公司 | Biological specimen collection handles bottle |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6921370B2 (en) * | 2002-07-25 | 2005-07-26 | Alfa Scientific Designs, Inc. | Specimen collection and storage and transport device and method |
CN2831084Y (en) * | 2005-09-30 | 2006-10-25 | 张志雄 | Disposable excrement and urine testing vessel |
CN104122113A (en) * | 2014-07-17 | 2014-10-29 | 河南科技大学第一附属医院 | Common specimen collecting-extracting container |
CN204718871U (en) * | 2015-05-27 | 2015-10-21 | 艾博生物医药(杭州)有限公司 | A kind ofly store and mix lid and the device of solid-liquid |
CN204971363U (en) * | 2015-09-08 | 2016-01-20 | 北京大学深圳医院 | Oral cavity sample collection ware |
-
2017
- 2017-07-18 CN CN201710586368.4A patent/CN107202725B/en active Active
- 2017-07-26 WO PCT/CN2017/094570 patent/WO2019014958A1/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001194365A (en) * | 1999-11-05 | 2001-07-19 | Sekisui Chem Co Ltd | Container and method for measuring cell function |
CN2800261Y (en) * | 2005-06-22 | 2006-07-26 | 常熟市矿山机电器材有限公司 | Dust sampling head |
CN200996897Y (en) * | 2006-09-15 | 2007-12-26 | 艾博生物医药(杭州)有限公司 | Sampler collecting container |
CN204142525U (en) * | 2014-10-29 | 2015-02-04 | 博奥生物集团有限公司 | A kind of micro liquid sampling sample adding device |
EP3171152A1 (en) * | 2015-11-19 | 2017-05-24 | Miltenyi Biotec GmbH | Process and device for isolating cells from biological tissue |
CN205843989U (en) * | 2016-08-05 | 2016-12-28 | 武汉康立优医疗发展有限公司 | Integral type secretions pretreatment unit |
CN207081595U (en) * | 2017-07-18 | 2018-03-09 | 杭州优思达生物技术有限公司 | Biological specimen collection handles bottle |
Also Published As
Publication number | Publication date |
---|---|
CN107202725A (en) | 2017-09-26 |
CN107202725B (en) | 2018-10-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2019014958A1 (en) | Biological sample collecting and processing bottle, and method of use therefor | |
JP2008542775A (en) | Device for collection, collection and transfer of biological samples | |
CN217677510U (en) | Virus collecting tube capable of quantitatively adding sample | |
CN202558865U (en) | Biology sampling swab | |
CN112179736A (en) | Biological safety collection processor for sputum microorganism detection and operation method thereof | |
US20040245125A1 (en) | Aerosol collection cap and container | |
CN105510109A (en) | Blood sample sampling pretreatment device and method | |
CN203195699U (en) | Disposable vacuum blood collection tube | |
CN206768084U (en) | A kind of PCR plate with PCR lids | |
CN103190922B (en) | Single use vacuum test tube | |
CN211971722U (en) | Automatic closing cap device of coupling | |
CN113956960A (en) | New coronavirus sampling tube | |
JP2006329728A (en) | Specimen collection liquid container | |
CN214334411U (en) | Saliva nucleic acid detection biosafety acquisition processor | |
JP2006329728A5 (en) | ||
JPH0274237A (en) | Universal joint for an injector | |
JP2006250860A (en) | Vessel for specimen-collecting liquid | |
CN207081595U (en) | Biological specimen collection handles bottle | |
CN204999590U (en) | Reagent bottle inner cap opening device | |
CN214654890U (en) | Fine virus sampling tube | |
CN109464164A (en) | A kind of disposable sampling pipe for the acquisition of livestock pathogeny liquid | |
CN212853534U (en) | Sample collection bottle | |
CN208733088U (en) | Sample rate separating liquid save set | |
CN107874787A (en) | Hydrops collection system | |
CN211713088U (en) | Sterile sampling device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 17918462 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 17918462 Country of ref document: EP Kind code of ref document: A1 |