WO2019013396A1 - Composition cosmétique contenant un extrait de fruit d'hippophae rhamnoides pour émulsion de blanchissement et son procédé de fabrication - Google Patents

Composition cosmétique contenant un extrait de fruit d'hippophae rhamnoides pour émulsion de blanchissement et son procédé de fabrication Download PDF

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WO2019013396A1
WO2019013396A1 PCT/KR2017/011965 KR2017011965W WO2019013396A1 WO 2019013396 A1 WO2019013396 A1 WO 2019013396A1 KR 2017011965 W KR2017011965 W KR 2017011965W WO 2019013396 A1 WO2019013396 A1 WO 2019013396A1
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weight
emulsion
cosmetic composition
phase
oil
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PCT/KR2017/011965
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English (en)
Korean (ko)
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김기섭
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(주)다럼앤바이오
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a whitening emulsion cosmetic composition comprising vitamin Nut fruit extract and a process for producing the same.
  • Skin is easily aged not only through natural processes but also by external factors such as ultraviolet rays, stress and skin side effects. During the aging process, the skin becomes partially blackened (pigmentation), which causes cosmetic problems.
  • the process in which pigmentation occurs in human skin is the most important step in the process of making pigment melanin.
  • Melanin is produced from melanin-forming cells in the skin.
  • Tyrosinase from Tyrosine is produced by enzymes.
  • the resulting melanin is delivered to the surrounding keratinocytes and delivered to the stratum corneum by skin turnovers of keratinocytes, eventually falling off the skin along with the time. Therefore, a certain amount of melanin should be produced and a certain amount should disappear through the skin horny to exhibit a certain skin color.
  • Pigmentation is caused by the fact that melanin is made too much, or that it does not come off well with the skin horny. Therefore, in order to prevent pigmentation and to exhibit skin whitening effect, a series of processes for synthesizing melanin in melanin-forming cells must be inhibited and inactivated.
  • polyglyceryl 10-stearate 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate and 0.1 to 5% by weight of phage-5 rape seed sterol;
  • vitamin A nut extract 0.1 to 20% by weight of vitamin A nut extract
  • a water-based emulsion cosmetic composition comprising:
  • n is a natural number of 2 to 10
  • a and b are molar fractions, a is 0.5 and b is 0.5;
  • c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.
  • a method of making a composition comprising:
  • n is a natural number of 2 to 10
  • a and b are molar fractions, a is 0.5 and b is 0.5;
  • c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.
  • the emulsion cosmetic composition for whitening which comprises the vitamin nuts extract of the present invention, contains stable nanoparticles of 50 m to 100 nm including vitamin nuts extract to provide excellent skin absorption and storage stability of the active ingredient.
  • the method of the present invention for producing a whitening emulsion cosmetic composition can be carried out by introducing a block copolymer of polyacrylic acid substituted with poly-D, L-lactic acid-co-glycolic acid and a diisocyanate compound into a highly effective stable nanoparticle emulsion cosmetic composition to provide.
  • FIG. 1 is a graph showing the results of the antioxidative efficacy evaluation (ABTS assay) of vitamin A fruit extract.
  • FIG. 2 is a graph showing the cytotoxicity test results of B16F10 cells of vitamin A fruit extract.
  • FIG. 3 is a graph showing the results of a melanogenesis inhibition assay of vitamin A fruit extract.
  • polyglyceryl 10-stearate 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate and 0.1 to 5% by weight of phage-5 rape seed sterol;
  • vitamin A nut extract 0.1 to 20% by weight of vitamin A nut extract
  • the present invention relates to a whitening emulsion cosmetic composition
  • a whitening emulsion cosmetic composition comprising water of a residual amount
  • n is a natural number of 2 to 10
  • a and b are molar fractions, a is 0.5 and b is 0.5;
  • c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.
  • the vitamin tree is also known as Hippophae rhamnoides L. (vitamin tree). It is a shrub belonging to the bloody tree and contains more than 100 kinds of components. In particular, it contains effective ingredients such as vitamins (A, B, C, E, F and K) . It grows well in the cold of winter and the high temperatures of summer, and has a strong adaptability that grows well in the barren zone. It has already been reported that antioxidant activity of Sanjia wood is investigated, and fatty acid content, cancer prevention, and immune system of Sanjay tree are being studied. Beta carotene is contained in the fruit tree.
  • the emulsifier is contained in an amount of 1 to 10% by weight based on the total weight of the cosmetic composition.
  • the cosmetic composition may have a stable and transparent appearance.
  • the oil is more preferably contained in an amount of 5 to 20% by weight based on the total weight of the cosmetic composition. When it is included in the above range, emulsion stability can be more excellent.
  • poly-D L-lactic acid-co-glycolic acid and polyacrylic acid substituted with a diisocyanate compound
  • poly-D L-lactic acid-co-glycolic acid and polyacrylic acid substituted with a diisocyanate compound
  • poly-D, L-lactic acid-co- glycolic acid is included as a hydrophobic part
  • the substituted polyacrylic acid is included as a hydrophilic moiety.
  • polyacrylic acid substituted by poly-D L-lactic acid-co-glycolic acid (Formula 2) and diisocyanate compound (Formula 3 below) can be produced by the combination of an isocyanate group and a hydroxyl group of a carboxyl group. a block copolymer of polyacrylic acid substituted with -co-glycolic acid and diisocyanate compound is formed.
  • the poly-D, L-lactic acid-co-glycolic acid preferably has a weight average molecular weight of 1,000 to 80,000, and the copolymer of polyacrylic acid substituted with the diisocyanate compound has a weight average molecular weight of 100 to 10,000.
  • the copolymer of polyacrylic acid substituted with the diisocyanate compound has a weight average molecular weight of 100 to 10,000.
  • the average particle diameter of the copolymer is preferably from 10 to 100 nm. When such a particle size is used, penetration into the skin and collection of the active ingredient are excellent.
  • the thus obtained copolymer is remarkably stable in an aqueous solution as compared with a low molecular weight micelle.
  • This characteristic of the copolymer means that the water-in-oil type nanoparticulate emulsion cosmetic composition of the present invention can be stored in a stable state for a long period of time and can maintain its structure for a considerable period of time in the body.
  • the emulsion cosmetic composition is prepared by adding 0.1 to 5% by weight of an extract obtained by hot-water extracting a mixture of rice hull, hull, buckwheat husk and peeled dried soybeans at a weight ratio of 1: 3: 1 to 3: 1 to 3: .
  • the rice hull, hull, buckwheat husk, and husked dried soybean hulls have been found to be grains or fruit husks and are not widely used as active ingredients, but are discarded.
  • the rice husk contains 35 to 46% of crude fiber, 22 to 5% of soluble saccharide, 13 to 21% of ash, and 2 to 3% of crude protein. It is known that the urine is useful for improving digestion and preventing skin aging. Since the buckwheat husk clears the blood, it can perform the function of preventing the skin trouble.
  • soybean is excellent for respiratory diseases such as rhinitis, allergic rhinitis, cold, sinusitis, runny nose, sneezing, nasal obstruction and asthma.
  • respiratory diseases such as rhinitis, allergic rhinitis, cold, sinusitis, runny nose, sneezing, nasal obstruction and asthma.
  • it can stimulate growth and strengthens bones, so it helps to grow children.
  • skin diseases because of atopy, acne and skin moisturizing effect. It removes wastes and helps constipation and obesity, And it is good for symptom such as sloppy call.
  • it is excellent for inflammation of liver and boil, and is good for oral mucositis, etc. It is known that it promotes blood circulation, strengthens immunity, excretes toxins in the body and detoxifies.
  • the emulsion cosmetic composition may be at least one selected from the group consisting of a hair tonic, a scarf treatment, a hair cream, a general ointment, a softening longevity, a convergent lotion, a nutritional lotion, an eye cream, a nutritional cream, a massage cream, a cleansing cream, a cleansing foam, a cleansing water, , Body lotion, body cream, body oil, body essence, makeup base, foundation, hair dye, shampoo, rinse, body cleanser, toothpaste, or mouthwash.
  • the auxiliary component used in the preparation of the emulsion cosmetic composition may further include coloring matters, fragrance, preservative or thickening agent.
  • the content of the auxiliary component may be, for example, 0 to 20% by weight, Lt; / RTI >
  • the nanoemulsion according to the present invention is not particularly limited as long as it has a low viscosity to such an extent that desired dispersibility can be achieved in order to increase the content of the internal phase and effectively deliver the active ingredient.
  • a low viscosity for example, Of less than 3000 cps, more specifically less than 2000 cps.
  • the 'low viscosity' emulsion contains all of the emulsions belonging to the aforementioned viscosity ranges from when the viscosity can not be measured experimentally because the viscosity is very small.
  • the viscosity range is 0 , For example from 0 to 5000 cps, specifically from 1 to 3000 cps, more specifically from 5 to 2000 cps.
  • the emulsion is nano-sized and is not particularly limited as long as it can produce an emulsion having a low viscosity while improving the stability of the emulsion.
  • the emulsion may have an average size of 250 nm or less, specifically 200 nm or less.
  • the emulsion may have any size falling within the above average size range, but may have an average size of, for example, 10 to 250 nm, specifically 20 to 200 nm.
  • n is a natural number of 2 to 10
  • a and b are molar fractions, a is 0.5 and b is 0.5;
  • c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.
  • each component described above can be applied to all of the components described in the water-in-oil type nano-particle emulsion cosmetic composition. Therefore, redundant description is omitted.
  • Rice hull, husk, buckwheat husks, and peanut dried soybeans were mixed in an amount of 300 g each, put into 12 liters of distilled water, and extracted at 100 ° C for 24 hours to prepare a hot water extract.
  • acrylic acid 40 parts by weight was added to a 1 L reactor equipped with a cooling device so that nitrogen gas was refluxed and the temperature thereof was easily controlled.
  • 60 parts by weight of ethyl acetate (EAc; ethyl acetate) was poured into the solvent, and nitrogen gas was purged for 30 minutes.
  • the temperature was maintained at 60 ⁇ ⁇ and 0.1 part by weight of AIBN (azobisisobutyronitrile) as a reaction initiator was added and reacted for 3 hours to prepare an acrylic acid polymer having a weight average molecular weight of 1,500.
  • AIBN azobisisobutyronitrile
  • ethyl acetate 100 parts by weight of ethyl acetate (EAc; ethyl aceate) was added to a 1 L reactor equipped with a cooling device to easily regulate the temperature of the reflux of the nitrogen gas.
  • 100 parts by weight of the acrylic acid polymer solid component prepared above and 100 parts by weight of hexamethylene di 10 parts by weight of isocyanate, 54 mg of magnesium trifluorosulfonate, 0.5 part by weight of lonol and 0.15 part by weight of Tinuvin were added. And heated to 110 deg. Heating was carried out for 15 hours to prepare acrylic acid substituted with hexamethylene diisocyanate.
  • the mixture was heated for 15 hours, filtered through a nylon filter having a pore size of 0.45 micrometer, dispersed in tertiary distilled water, and then dialyzed to remove unreacted materials and reaction reagents to prepare a block copolymer.
  • the aqueous phase was stirred at 2,500 to 3,500 rpm and emulsified to form a micro-sized first emulsion phase.
  • the emulsion phase was stirred at 2,500 to 3,500 rpm in the emulsification tank.
  • the first emulsion phase was cooled to 37 to 50 ⁇ .
  • the first emulsion phase was put into a high-pressure emulsifier at a temperature of 37 to 50 ° C and secondary emulsified 2 to 3 times at a pressure of 600 to 1,500 bar to prepare a whitening emulsion cosmetic composition.
  • the emulsion cosmetic composition for whitening was prepared in the same manner as in Example 1, except that the rice husks, hull, buckwheat husks, and peeled dried bean curds prepared in Preparation Example 2 were further added in an amount of 3 wt% .
  • Test Example 1 Measurement of emulsion particle size and evaluation of stability of nano emulsion by particle size change
  • the particle size of the water-in-oil type nanoparticle emulsion cosmetic compositions of the present invention obtained according to Example 1 was measured using Mastersizer 2000 (Malvern Instrument, UK) by the dynamic light scattering principle, Are shown in Table 1 below. At this time, the measurement of the particle size was carried out under the following conditions by diluting the nano emulsion diluted solution with purified water to have a turbidity of 10-20%.
  • Measurement time 2 minutes, the number of measurements per second: 5 ⁇ 10 3, temperature: 20 °C, viscosity: 0.89 centipoise, particle refractive index: 1.4, refractive index of dispersion medium: 1.33
  • Particle size measurements were made after one day of manufacture and after storage for 6 months at 40 ° C for two times to evaluate the thermodynamic stability of the nanoemulsion after long term storage at high temperature.
  • Test Example 2 Stability of emulsification by visual observation
  • Example 1 The emulsion stability of the water-in-oil type nano-emulsion cosmetic compositions obtained in Example 1 was evaluated by observing the naked eye as follows with respect to the particle size measurement, and the results are shown in Table 1 below.
  • the emulsion state of the compositions of Example 1 after storage at room temperature (about 25 ° C) and at 40 ° C for 6 months was compared with that immediately after the preparation.
  • the unstable state was observed by visual observation as sedimentation, separation, drainage, creaming, and union.
  • the emulsion stability is evaluated as a percentage (%) of the stable part excluding the unstable part as a whole.
  • Emulsion stability (%) [(total - unstable part) / total] ⁇ 100%
  • Nanoparticle emulsion cosmetic composition Particle Size (nm) Increase in particle size (%) Stability of emulsification by visual observation (%) After the preparation, storage at room temperature for 1 day After storage for 6 months at 40 ° C
  • Particle Size (nm) Increase in particle size (%) Stability of emulsification by visual observation (%) After the preparation, storage at room temperature for 1 day After storage for 6 months at 40 ° C
  • Test Example 3 Evaluation of activity of hot water extract of vitamin Nut
  • B16F10 cells were cultured in DMEM medium (+ 10% FBS, 1% Antibiotics)
  • the cultured cells were divided into 2 ⁇ 10 5 cells / flask in a cell culture flask (25 cm 2), cultured for 24 hours
  • the antioxidative activity of vitamin A fruit extract showed an antioxidative activity similar to that of a typical antioxidant, Ascorbic acid 40 ⁇ g / ml, in a 200-fold diluted solution.
  • the antioxidant activity was judged to be effective at the above concentration.
  • the cytotoxicity test of B16F10 cells of vitamin A fruit extract showed a toxicity (Cell Viability (% of control) ⁇ 80%) in a 100-fold dilution-treated group, No toxicity was observed in the diluted solution treatment group. Therefore, the whitening effect was judged in the remaining groups except for the toxic 100 - fold dilution group.
  • the amount of melanin produced in the ⁇ -MSH alone treatment group was about 89% and 200 times And about 52% in the diluted solution - treated group.
  • melanin formation inhibitory effect was similar to that of Arbutin (200 ⁇ g / ml), which is a representative whitening substance. As the concentration of the sample increased, the amount of melanin was decreased. Therefore, it was judged that there was a whitening effect at the above concentration.

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Abstract

La présente invention est conçue pour résoudre les inconvénients de la technologie actuelle, et vise à fournir une composition cosmétique contenant un extrait de fruit d'Hippophae rhamnoides pour une émulsion de blanchissement et un procédé pour la fabriquer, la composition cosmétique contenant l'extrait de fruit d'Hippophae rhamnoides pour émulsion de blanchissement ayant un taux d'absorption au niveau de la peau et une stabilité au stockage excellents en contenant de 50 m à 100 nm de nanoparticules stables contenant l'extrait de fruit d'Hippophae rhamnoides.
PCT/KR2017/011965 2017-07-14 2017-10-27 Composition cosmétique contenant un extrait de fruit d'hippophae rhamnoides pour émulsion de blanchissement et son procédé de fabrication WO2019013396A1 (fr)

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KR10-2017-0089438 2017-07-14
KR1020170089438A KR102016164B1 (ko) 2017-07-14 2017-07-14 비타민나무 열매 추출물을 포함하는 미백용 에멀션 화장료 조성물 및 그의 제조방법

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Cited By (2)

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CN114668089A (zh) * 2022-03-09 2022-06-28 山东省食品发酵工业研究设计院 一种防止沙棘果饮料油脂上浮的生产方法
CN114917163A (zh) * 2022-06-17 2022-08-19 暨南大学 一种包含沙棘叶纳米超细粉的美白抗敏除皱化妆品组合物

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KR102075539B1 (ko) * 2019-05-15 2020-03-02 사단법인 부산고등어식품전략사업단 고등어 부산물과 비타민나무 열매를 포함하는 반려동물 사료 및 그 제조방법

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CN114668089A (zh) * 2022-03-09 2022-06-28 山东省食品发酵工业研究设计院 一种防止沙棘果饮料油脂上浮的生产方法
CN114668089B (zh) * 2022-03-09 2024-02-02 山东省食品发酵工业研究设计院 一种防止沙棘果饮料油脂上浮的生产方法
CN114917163A (zh) * 2022-06-17 2022-08-19 暨南大学 一种包含沙棘叶纳米超细粉的美白抗敏除皱化妆品组合物
CN114917163B (zh) * 2022-06-17 2023-09-22 暨南大学 一种包含沙棘叶纳米超细粉的美白抗敏除皱化妆品组合物

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