WO2019013396A1 - Cosmetic composition containing hippophae rhamnoides fruit extract for whitening emulsion and method for manufacturing same - Google Patents

Abstract

The present invention is contrived to resolve shortcomings of existing technology, and aims to provide a cosmetic composition containing Hippophae rhamnoides fruit extract for a whitening emulsion and a method for manufacturing same, the cosmetic composition containing the Hippophae rhamnoides fruit extract for the whitening emulsion having an excellent skin absorption rate and storage stability by containing 50m to 100nm of stable nanoparticles containing the Hippophae rhamnoides fruit extract.

Description

Whitening emulsion cosmetic composition comprising vitamin Nut fruit extract and method for producing the same

The present invention relates to a whitening emulsion cosmetic composition comprising vitamin Nut fruit extract and a process for producing the same.

Skin is easily aged not only through natural processes but also by external factors such as ultraviolet rays, stress and skin side effects. During the aging process, the skin becomes partially blackened (pigmentation), which causes cosmetic problems.

The process in which pigmentation occurs in human skin is the most important step in the process of making pigment melanin. Melanin is produced from melanin-forming cells in the skin. Tyrosinase from Tyrosine is produced by enzymes. The resulting melanin is delivered to the surrounding keratinocytes and delivered to the stratum corneum by skin turnovers of keratinocytes, eventually falling off the skin along with the time. Therefore, a certain amount of melanin should be produced and a certain amount should disappear through the skin horny to exhibit a certain skin color.

Pigmentation, on the other hand, is caused by the fact that melanin is made too much, or that it does not come off well with the skin horny. Therefore, in order to prevent pigmentation and to exhibit skin whitening effect, a series of processes for synthesizing melanin in melanin-forming cells must be inhibited and inactivated.

The skin of modern people has been remarkably deteriorated in their ability to defend extrinsic factors due to the continual increase in the quantity of ultraviolet rays due to the destruction of the ozone layer and the pollutants due to continuous environmental destruction.

Therefore, means such as cosmetics for inhibiting a series of processes for effectively synthesizing melanin in melanin-forming cells are becoming more and more important.

However, in the case of conventional whitening cosmetic compositions, it seems that the synthesis process of melanin does not effectively inhibit a series of processes, and furthermore, it seems to damage the skin due to side effects. Therefore, it is required to solve such a problem.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned disadvantages of the prior art,

It is an object of the present invention to provide a whitening emulsion cosmetic composition containing vitamin nuts extract having excellent skin absorption and storage stability by containing stable nanoparticles of 50 m to 100 nm containing vitamin A fruit extract and a method for producing the same. .

According to the present invention,

0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate and 0.1 to 5% by weight of phage-5 rape seed sterol;

0.1 to 5% by weight of isopropyl myristate, 0.1 to 5% by weight of macadamia oil, 0.1 to 5% by weight of manuka oil and 0.1 to 5% by weight of perfluoropolyether;

1 to 15% by weight of glycerin and 1 to 15% by weight of 1,2-hexanediol;

0.5 to 20% by weight of a block copolymer represented by the following formula (1);

0.1 to 20% by weight of vitamin A nut extract;

0.5 to 3% by weight of an ester emollient;

5 to 15% by weight of phenylbenzimidazolesulfonic acid; And

A water-based emulsion cosmetic composition comprising:

[Chemical Formula 1]

In this formula,

n is a natural number of 2 to 10,

a and b are molar fractions, a is 0.5 and b is 0.5;

c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.

In addition,

(a) 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate, and 0.1 to 5 0.1 to 5 wt% of myristyl alcohol, 0.1 to 5 wt% of manuka oil, 0.1 to 5 wt% of perfluoropolyether, 1 to 15 wt% of glycerin, 1 to 15% by weight of 2-hexanediol, and 0.5 to 20% by weight of a block copolymer represented by the following formula (1) are mixed and heated to 75 to 85 캜 to prepare an oil phase;

 (b) 0.1 to 20% by weight of a vitamin A hot water extract, 0.5 to 3% by weight of an ester emollient, 5 to 15% by weight of phenylbenzimidazole succinimide acid and 5 to 15% by weight based on the total weight of the cosmetic composition, ≪ / RTI > to < RTI ID = 0.0 > 85 C < / RTI &

(c) stirring the water phase in an emulsification tank at 2,500 to 3,500 rpm, adding an oil phase to the emulsion and stirring the mixture at 2,500 to 3,500 rpm to form a micro-sized first emulsion phase;

(d) cooling the first emulsion phase to 37 to 50 占 폚; And

(e) adding the first emulsion phase to a high-pressure emulsifier at a temperature of from 37 to 50 ° C, and secondarily refining the emulsion phase two to three times at a pressure of 600 to 1,500 bar. A method of making a composition comprising:

[Chemical Formula 1]

In this formula,

n is a natural number of 2 to 10,

a and b are molar fractions, a is 0.5 and b is 0.5;

c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.

The emulsion cosmetic composition for whitening, which comprises the vitamin nuts extract of the present invention, contains stable nanoparticles of 50 m to 100 nm including vitamin nuts extract to provide excellent skin absorption and storage stability of the active ingredient.

The method of the present invention for producing a whitening emulsion cosmetic composition can be carried out by introducing a block copolymer of polyacrylic acid substituted with poly-D, L-lactic acid-co-glycolic acid and a diisocyanate compound into a highly effective stable nanoparticle emulsion cosmetic composition to provide.

FIG. 1 is a graph showing the results of the antioxidative efficacy evaluation (ABTS assay) of vitamin A fruit extract.

FIG. 2 is a graph showing the cytotoxicity test results of B16F10 cells of vitamin A fruit extract. FIG.

FIG. 3 is a graph showing the results of a melanogenesis inhibition assay of vitamin A fruit extract. FIG.

Hereinafter, the present invention will be described in detail.

0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate and 0.1 to 5% by weight of phage-5 rape seed sterol;

0.1 to 5% by weight of isopropyl myristate, 0.1 to 5% by weight of macadamia oil, 0.1 to 5% by weight of manuka oil and 0.1 to 5% by weight of perfluoropolyether;

1 to 15% by weight of glycerin and 1 to 15% by weight of 1,2-hexanediol;

0.5 to 20% by weight of a block copolymer represented by the following formula (1);

0.1 to 20% by weight of vitamin A nut extract;

0.5 to 3% by weight of an ester emollient;

5 to 15% by weight of phenylbenzimidazolesulfonic acid; And

The present invention relates to a whitening emulsion cosmetic composition comprising water of a residual amount,

[Chemical Formula 1]

In this formula,

n is a natural number of 2 to 10,

a and b are molar fractions, a is 0.5 and b is 0.5;

c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.

The vitamin tree is also known as Hippophae rhamnoides L. (vitamin tree). It is a shrub belonging to the bloody tree and contains more than 100 kinds of components. In particular, it contains effective ingredients such as vitamins (A, B, C, E, F and K) . It grows well in the cold of winter and the high temperatures of summer, and has a strong adaptability that grows well in the barren zone. It has already been reported that antioxidant activity of Sanjia wood is investigated, and fatty acid content, cancer prevention, and immune system of Sanjay tree are being studied. Beta carotene is contained in the fruit tree.

It is more preferable that the emulsifier is contained in an amount of 1 to 10% by weight based on the total weight of the cosmetic composition. When included in the above range, the cosmetic composition may have a stable and transparent appearance.

The oil is more preferably contained in an amount of 5 to 20% by weight based on the total weight of the cosmetic composition. When it is included in the above range, emulsion stability can be more excellent.

In the block copolymer of poly-D, L-lactic acid-co-glycolic acid and polyacrylic acid substituted with a diisocyanate compound, poly-D, L-lactic acid-co- glycolic acid is included as a hydrophobic part, The substituted polyacrylic acid is included as a hydrophilic moiety.

In the above, polyacrylic acid substituted by poly-D, L-lactic acid-co-glycolic acid (Formula 2) and diisocyanate compound (Formula 3 below) can be produced by the combination of an isocyanate group and a hydroxyl group of a carboxyl group. a block copolymer of polyacrylic acid substituted with -co-glycolic acid and diisocyanate compound is formed.

(2)

(3)

The poly-D, L-lactic acid-co-glycolic acid preferably has a weight average molecular weight of 1,000 to 80,000, and the copolymer of polyacrylic acid substituted with the diisocyanate compound has a weight average molecular weight of 100 to 10,000. Are preferred for the formation of nanoparticle emulsions.

The average particle diameter of the copolymer is preferably from 10 to 100 nm. When such a particle size is used, penetration into the skin and collection of the active ingredient are excellent. The thus obtained copolymer is remarkably stable in an aqueous solution as compared with a low molecular weight micelle. This characteristic of the copolymer means that the water-in-oil type nanoparticulate emulsion cosmetic composition of the present invention can be stored in a stable state for a long period of time and can maintain its structure for a considerable period of time in the body.

The emulsion cosmetic composition is prepared by adding 0.1 to 5% by weight of an extract obtained by hot-water extracting a mixture of rice hull, hull, buckwheat husk and peeled dried soybeans at a weight ratio of 1: 3: 1 to 3: 1 to 3: .

The rice hull, hull, buckwheat husk, and husked dried soybean hulls have been found to be grains or fruit husks and are not widely used as active ingredients, but are discarded.

The rice husk contains 35 to 46% of crude fiber, 22 to 5% of soluble saccharide, 13 to 21% of ash, and 2 to 3% of crude protein. It is known that the urine is useful for improving digestion and preventing skin aging. Since the buckwheat husk clears the blood, it can perform the function of preventing the skin trouble.

The above-mentioned peeled dried soybeans are said to protect the intestines and stomachs in the main herbaceous gland, warm the genus, enhance the kidney function, protect the epidermis, and have an effect on boils and hemorrhagic inflammatory diseases. It is known that soybean is excellent for respiratory diseases such as rhinitis, allergic rhinitis, cold, sinusitis, runny nose, sneezing, nasal obstruction and asthma. In addition, it can stimulate growth and strengthens bones, so it helps to grow children. It is effective against skin diseases because of atopy, acne and skin moisturizing effect. It removes wastes and helps constipation and obesity, And it is good for symptom such as sloppy call. In addition, it is excellent for inflammation of liver and boil, and is good for oral mucositis, etc. It is known that it promotes blood circulation, strengthens immunity, excretes toxins in the body and detoxifies.

The emulsion cosmetic composition may be at least one selected from the group consisting of a hair tonic, a scarf treatment, a hair cream, a general ointment, a softening longevity, a convergent lotion, a nutritional lotion, an eye cream, a nutritional cream, a massage cream, a cleansing cream, a cleansing foam, a cleansing water, , Body lotion, body cream, body oil, body essence, makeup base, foundation, hair dye, shampoo, rinse, body cleanser, toothpaste, or mouthwash.

The auxiliary component used in the preparation of the emulsion cosmetic composition may further include coloring matters, fragrance, preservative or thickening agent. The content of the auxiliary component may be, for example, 0 to 20% by weight, Lt; / RTI >

The nanoemulsion according to the present invention is not particularly limited as long as it has a low viscosity to such an extent that desired dispersibility can be achieved in order to increase the content of the internal phase and effectively deliver the active ingredient. For example, Of less than 3000 cps, more specifically less than 2000 cps. The 'low viscosity' emulsion contains all of the emulsions belonging to the aforementioned viscosity ranges from when the viscosity can not be measured experimentally because the viscosity is very small. When the viscosity is not experimentally measured, the viscosity range is 0 , For example from 0 to 5000 cps, specifically from 1 to 3000 cps, more specifically from 5 to 2000 cps.

The emulsion is nano-sized and is not particularly limited as long as it can produce an emulsion having a low viscosity while improving the stability of the emulsion. For example, the emulsion may have an average size of 250 nm or less, specifically 200 nm or less.

The emulsion may have any size falling within the above average size range, but may have an average size of, for example, 10 to 250 nm, specifically 20 to 200 nm.

In addition,

(a) 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate, and 0.1 to 5 0.1 to 5 wt% of myristyl alcohol, 0.1 to 5 wt% of manuka oil, 0.1 to 5 wt% of perfluoropolyether, 1 to 15 wt% of glycerin, 1 to 15% by weight of 2-hexanediol, and 0.5 to 20% by weight of a block copolymer represented by the following formula (1) are mixed and heated to 75 to 85 캜 to prepare an oil phase;

(b) 0.1 to 20% by weight of a vitamin A hot water extract, 0.5 to 3% by weight of an ester emollient, 5 to 15% by weight of phenylbenzimidazole succinimide acid and 5 to 15% by weight based on the total weight of the cosmetic composition, ≪ / RTI > to < RTI ID = 0.0 > 85 C < / RTI &

(c) stirring the water phase in an emulsification tank at 2,500 to 3,500 rpm, adding an oil phase to the emulsion and stirring the mixture at 2,500 to 3,500 rpm to form a micro-sized first emulsion phase;

(d) cooling the first emulsion phase to 37 to 50 占 폚; And

(e) adding the first emulsion phase to a high-pressure emulsifier at a temperature of from 37 to 50 ° C, and secondarily refining the emulsion phase two to three times at a pressure of 600 to 1,500 bar. ≪ RTI ID = 0.0 >

[Chemical Formula 1]

In this formula,

n is a natural number of 2 to 10,

a and b are molar fractions, a is 0.5 and b is 0.5;

c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.

The content of each component described above can be applied to all of the components described in the water-in-oil type nano-particle emulsion cosmetic composition. Therefore, redundant description is omitted.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Production Example 1: Preparation of hot water extract of vitamin Nut fruit

1 kg of vitamin nuts were added to 10 liters of distilled water and extracted at 100 ° C for 24 hours to produce hot water extract of vitamin Nut.

Manufacturing example  2: chaff, Julie , Buckwheat husks, and Peeled  Arid soybean Hot water extract  Produce

Rice hull, husk, buckwheat husks, and peanut dried soybeans were mixed in an amount of 300 g each, put into 12 liters of distilled water, and extracted at 100 ° C for 24 hours to prepare a hot water extract.

Manufacturing example  3: Poly - D, L - lactic acid-co- Glycolic acid Diisocyanate  Substituted with a compound Of polyacrylic acid  Preparation of block copolymers

(1) Preparation of polyacrylic acid substituted with diisocyanate compound

40 parts by weight of acrylic acid was added to a 1 L reactor equipped with a cooling device so that nitrogen gas was refluxed and the temperature thereof was easily controlled. 60 parts by weight of ethyl acetate (EAc; ethyl acetate) was poured into the solvent, and nitrogen gas was purged for 30 minutes. The temperature was maintained at 60 占 폚 and 0.1 part by weight of AIBN (azobisisobutyronitrile) as a reaction initiator was added and reacted for 3 hours to prepare an acrylic acid polymer having a weight average molecular weight of 1,500.

100 parts by weight of ethyl acetate (EAc; ethyl aceate) was added to a 1 L reactor equipped with a cooling device to easily regulate the temperature of the reflux of the nitrogen gas. 100 parts by weight of the acrylic acid polymer solid component prepared above and 100 parts by weight of hexamethylene di 10 parts by weight of isocyanate, 54 mg of magnesium trifluorosulfonate, 0.5 part by weight of lonol and 0.15 part by weight of Tinuvin were added. And heated to 110 deg. Heating was carried out for 15 hours to prepare acrylic acid substituted with hexamethylene diisocyanate.

(2) Preparation of block copolymer of poly-D, L-lactic acid-co-glycolic acid and polyacrylic acid substituted with diisocyanate compound

100 ml of dimethylformamide and 290 mg of N, N-carbonyldiimidazole (CDI) were added to the reaction vessel and stirred. To this was added 20 g of poly-D, L-lactic acid-co-glycolic acid (RG502, Boehringer Ingelheim, Germany) having a number average molecular weight of 11,000 to obtain a hydroxyaldehyde group of poly-D, L-lactic acid- Lt; / RTI > 0.5 mg of lonol, 0.15 mg of Tinuvin and 25 g of polyacrylic acid having a number average molecular weight of 2,000 prepared in Preparation Example 1 were added to the solution and heated to 110 ° C. The mixture was heated for 15 hours, filtered through a nylon filter having a pore size of 0.45 micrometer, dispersed in tertiary distilled water, and then dialyzed to remove unreacted materials and reaction reagents to prepare a block copolymer.

Example  1: Underwater type nano particle emulsion Cosmetics  Preparation of composition

5% by weight of polyglyceryl 10-stearate, 3% by weight of polyglyceryl-3-methyl glucose distearate, 5% by weight of fat-5 rape seed sterol, 5% by weight of isopropyl myristate 5% by weight of malachite oil, 5% by weight of manuka oil, 5% by weight of perfluoropolyether, 10% by weight of glycerin and 12% by weight of 1,2-hexanediol, 5% by weight of the block copolymer prepared in Preparation Example 2, And heated to 75 to 85 캜 to prepare an oily portion.

10% by weight of vitamin A fruit extract, 2% by weight of ester emulsion, 7% by weight of phenylbenzimidazole sulfamic acid, and the balance of water, prepared in Production Example 1, were mixed with the total weight of the cosmetic composition, To prepare an aqueous phase.

The aqueous phase was stirred at 2,500 to 3,500 rpm and emulsified to form a micro-sized first emulsion phase. The emulsion phase was stirred at 2,500 to 3,500 rpm in the emulsification tank. The first emulsion phase was cooled to 37 to 50 캜. The first emulsion phase was put into a high-pressure emulsifier at a temperature of 37 to 50 ° C and secondary emulsified 2 to 3 times at a pressure of 600 to 1,500 bar to prepare a whitening emulsion cosmetic composition.

Example  2: Underwater type nanoparticle emulsion Cosmetics  Preparation of composition

The emulsion cosmetic composition for whitening was prepared in the same manner as in Example 1, except that the rice husks, hull, buckwheat husks, and peeled dried bean curds prepared in Preparation Example 2 were further added in an amount of 3 wt% .

Test Example  1: Measurement of emulsion particle size and evaluation of stability of nano emulsion by particle size change

The particle size of the water-in-oil type nanoparticle emulsion cosmetic compositions of the present invention obtained according to Example 1 was measured using Mastersizer 2000 (Malvern Instrument, UK) by the dynamic light scattering principle, Are shown in Table 1 below. At this time, the measurement of the particle size was carried out under the following conditions by diluting the nano emulsion diluted solution with purified water to have a turbidity of 10-20%.

Measurement time: 2 minutes, the number of measurements per second: 5 × 10 ^3, temperature: 20 ℃, viscosity: 0.89 centipoise, particle refractive index: 1.4, refractive index of dispersion medium: 1.33

Particle size measurements were made after one day of manufacture and after storage for 6 months at 40 ° C for two times to evaluate the thermodynamic stability of the nanoemulsion after long term storage at high temperature.

Test Example  2. Stability of emulsification by visual observation

The emulsion stability of the water-in-oil type nano-emulsion cosmetic compositions obtained in Example 1 was evaluated by observing the naked eye as follows with respect to the particle size measurement, and the results are shown in Table 1 below.

The emulsion state of the compositions of Example 1 after storage at room temperature (about 25 ° C) and at 40 ° C for 6 months was compared with that immediately after the preparation. The unstable state was observed by visual observation as sedimentation, separation, drainage, creaming, and union. The emulsion stability is evaluated as a percentage (%) of the stable part excluding the unstable part as a whole.

Emulsion stability (%) = [(total - unstable part) / total] × 100%

Nanoparticle emulsion cosmetic composition	Particle Size (nm)		Increase in particle size (%)	Stability of emulsification by visual observation (%)
	After the preparation, storage at room temperature for 1 day	After storage for 6 months at 40 ° C
Example 1	80	83	4.8	94

Test Example 3: Evaluation of activity of hot water extract of vitamin Nut

The sulfation efficacy and whitening efficacy of the hot water extract of Batamin tuberosum prepared in Preparation Example 1 was evaluated by Chuncheon Bio Industry Promotion Agency.

1. Experimental Method

end. Antioxidant efficacy evaluation (using ABTS assay)

1) Sample information

(1) Filtered with 0.45μm filter

(2) Preparation of sample: 100 times, 200 times, 400 times diluted to use

2) Evaluation method

(1) Experimental material

- 7 mM solution of ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)

- Potassium persulfate (K ₂ S ₂ O ₈ ) 140 mM solution

- Standard solution (Ascorbic acid 80 g / ml, 40 g / ml, 20 g / ml, 10 g / ml)

- 96 well plate

- ELISA reader

(2) Procedure of experiments

a. ABTS + Stock solution was prepared and diluted such that the absorbance (734 nm) value was 0.68 ~ 0.72 after standing for 24 hours.

b. Add 20 μl of sample and standard solution to 96 well plate

c. Add 180 μl of ABTS + solution per well

d. Measurement of absorbance (734 nm) after 10 min reaction at room temperature in dark room

I. Evaluation of whitening efficacy (using Melanogenesis inhibition assay)

1) Sample information

(1) Filtered with 0.45μm filter

(2) Preparation of sample: Dilute 10 times, 20 times, 40 times

2) Evaluation method

(1) Experimental material

- melanin-producing cell line B16F10 cell (ATCC CRL-6475)

- DMEM medium (+ 10% FBS, 1% Antibiotics)

- Positive control (Arbutin 2 mg / ml)

- 37 ° C CO ₂ incubator

- PBS (Phosphate Buffered Saline) pH 7.4

- 50 uM α-MSH (α-Melanocyte Stimulating Hormone) stock solution

- Trypsin-EDTA

- 1 M NaOH (+ 10% DMSO)

- Cell Counting Kit-8 (Manufacturer: Dojindo)

- Cell culture flask (25 cm 2, 75 cm 2), 96 well plate

(2) Procedure of experiments

a. B16F10 cells were cultured in DMEM medium (+ 10% FBS, 1% Antibiotics)

b. The cultured cells were divided into 2 × 10 5 cells / flask in a cell culture flask (25 cm 2), cultured for 24 hours

c. After removing the culture solution, 4.5 ml of medium containing α-MSH (final concentration 50 nM) and 0.5 ml of sample were added and cultured for 48 hours (*

d. After removal of the culture medium, the cells were exchanged with fresh medium for cytotoxicity using the CCK-8 assay. Only the cell viability (% of control) ≥ 80%

e. Cells were recovered using trypsin-EDTA, and after removing the culture solution, 1 M NaOH

(+ 10% DMSO) solution to dissolve cells and obtain intracellular melanin

f. Melanin-soluble lysate was used to measure the absorbance at 490 nm to calculate the amount of melanin synthesis (%) versus cell number

2. Experimental results

end. Antioxidant efficacy evaluation (ABTS assay)

As shown in FIG. 1, the antioxidative activity of vitamin A fruit extract (ABTS assay) showed an antioxidative activity similar to that of a typical antioxidant, Ascorbic acid 40 μg / ml, in a 200-fold diluted solution.

As the concentration of the sample increased, the radical scavenging activity increased. As a result, the antioxidant activity was judged to be effective at the above concentration.

I. Melanogenesis inhibition assay

As shown in Fig. 2, the cytotoxicity test of B16F10 cells of vitamin A fruit extract showed a toxicity (Cell Viability (% of control) ≤ 80%) in a 100-fold dilution-treated group, No toxicity was observed in the diluted solution treatment group. Therefore, the whitening effect was judged in the remaining groups except for the toxic 100 - fold dilution group.

As shown in FIG. 3, in the melanogenesis inhibition assay of melanogenesis inhibition assay, the amount of melanin produced in the α-MSH alone treatment group was about 89% and 200 times And about 52% in the diluted solution - treated group.

In the case of 200-fold diluted samples, melanin formation inhibitory effect was similar to that of Arbutin (200 μg / ml), which is a representative whitening substance. As the concentration of the sample increased, the amount of melanin was decreased. Therefore, it was judged that there was a whitening effect at the above concentration.

Claims (4)

1. 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate and 0.1 to 5% by weight of phage-5 rape seed sterol;

   0.1 to 5% by weight of isopropyl myristate, 0.1 to 5% by weight of macadamia oil, 0.1 to 5% by weight of manuka oil and 0.1 to 5% by weight of perfluoropolyether;

   1 to 15% by weight of glycerin and 1 to 15% by weight of 1,2-hexanediol;

   0.5 to 20% by weight of a block copolymer represented by the following formula (1);

   0.1 to 20% by weight of vitamin A nut extract;

   0.5 to 3% by weight of an ester emollient;

   5 to 15% by weight of phenylbenzimidazolesulfonic acid; And

   A whitening emulsion cosmetic composition comprising a residual amount of water:

   [Chemical Formula 1]

   

   In this formula,

   n is a natural number of 2 to 10,

   a and b are molar fractions, a is 0.5 and b is 0.5;

   c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.
2. The method according to claim 1,

   And 0.1 to 5% by weight of an extract obtained by hot-water extracting a mixture of rice hulls, hulls, buckwheat husks, and peeled dried soybeans at a weight ratio of 1: 3: 1 to 3: 1 to 3: 1 to 3 By weight of the composition.
3. The method according to claim 1,

   The whitening emulsion cosmetic composition may be at least one selected from the group consisting of a hair tonic, a scarf treatment, a hair cream, a general ointment, a softening longevity, a convergent lotion, a convergent lotion, a nutritional lotion, an eye cream, a nutritional cream, a massage cream, a cleansing cream, a cleansing foam, Wherein the emulsion cosmetic composition is used as a raw material for a pack, a body lotion, a body cream, a body oil, a body essence, a makeup base, a foundation, a hair dye, a shampoo, a rinse, a body cleanser, a toothpaste, or an oral cleanser.
4. (a) 0.1 to 5% by weight of polyglyceryl 10-stearate, 0.1 to 5% by weight of polyglyceryl-3-methyl glucose distearate, and 0.1 to 5 0.1 to 5 wt% of myristyl alcohol, 0.1 to 5 wt% of manuka oil, 0.1 to 5 wt% of perfluoropolyether, 1 to 15 wt% of glycerin, 1 to 15% by weight of 2-hexanediol, and 0.5 to 20% by weight of a block copolymer represented by the following formula (1) are mixed and heated to 75 to 85 캜 to prepare an oil phase;

    (b) 0.1 to 20% by weight of vitamin A hot water extract, 0.5 to 3% by weight of an ester emollient, 5 to 15% by weight of phenylbenzimidazole succinimide acid and 5 to 15% by weight of water are mixed with the total weight of the cosmetic composition Heating the mixture to 75 to 85 캜 to prepare a water phase;

   (c) stirring the water phase in an emulsification tank at 2,500 to 3,500 rpm, adding an oil phase to the emulsion and stirring the mixture at 2,500 to 3,500 rpm to form a micro-sized first emulsion phase;

   (d) cooling the first emulsion phase to 37 to 50 占 폚; And

   (e) adding the first emulsion phase to a high-pressure emulsifier at a temperature of from 37 to 50 ° C, and secondarily refining the emulsion phase two to three times at a pressure of 600 to 1,500 bar. Method of preparing the composition:

   [Chemical Formula 1]

   

   In this formula,

   n is a natural number of 2 to 10,

   a and b are molar fractions, a is 0.5 and b is 0.5;

   c and d are mole fractions, c is 0.05 to 0.2, d is 0.8 to 0.95, and c + d is 1.

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