WO2019009640A3 - 인플루엔자 백신용 바이러스 씨드 스톡의 제조 방법, 상기 씨드 스톡을 이용한 인플루엔자 예방 백신의 제조 방법 및 상기 방법에 의해 제조된 바이러스 씨드 스톡 - Google Patents

인플루엔자 백신용 바이러스 씨드 스톡의 제조 방법, 상기 씨드 스톡을 이용한 인플루엔자 예방 백신의 제조 방법 및 상기 방법에 의해 제조된 바이러스 씨드 스톡 Download PDF

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Publication number
WO2019009640A3
WO2019009640A3 PCT/KR2018/007630 KR2018007630W WO2019009640A3 WO 2019009640 A3 WO2019009640 A3 WO 2019009640A3 KR 2018007630 W KR2018007630 W KR 2018007630W WO 2019009640 A3 WO2019009640 A3 WO 2019009640A3
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WIPO (PCT)
Prior art keywords
seed stock
same
preparing influenza
virus seed
preparing
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PCT/KR2018/007630
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English (en)
French (fr)
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WO2019009640A2 (ko
Inventor
김윤희
박용욱
함동수
정환의
김훈
Original Assignee
에스케이바이오사이언스 주식회사
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Priority to BR112019018391A priority Critical patent/BR112019018391A2/pt
Priority to RU2019127445A priority patent/RU2748577C1/ru
Priority to EA202090042A priority patent/EA202090042A1/ru
Priority to AU2018295867A priority patent/AU2018295867B2/en
Priority to US16/628,228 priority patent/US11883483B2/en
Priority to PE2020000007A priority patent/PE20201252A1/es
Priority to CN201880016526.5A priority patent/CN110520525B/zh
Priority to JP2020500146A priority patent/JP7048716B2/ja
Application filed by 에스케이바이오사이언스 주식회사 filed Critical 에스케이바이오사이언스 주식회사
Priority to EP18827635.6A priority patent/EP3650536A4/en
Publication of WO2019009640A2 publication Critical patent/WO2019009640A2/ko
Publication of WO2019009640A3 publication Critical patent/WO2019009640A3/ko
Priority to SA519410070A priority patent/SA519410070B1/ar
Priority to CONC2020/0000021A priority patent/CO2020000021A2/es
Priority to PH12020500042A priority patent/PH12020500042A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 인플루엔자 백신 제조용 바이러스 씨드 스톡의 제조 방법 및 인플루엔자 백신 제조용 바이러스 씨드 스톡의 감염력을 증가시키는 방법, 상기 씨드 스톡을 이용해 인플루엔자 백신을 제조하는 방법, 상기 방법을 이용해 제조된 인플루엔자 예방 백신 및 감염력이 증가된 인플루엔자 백신 제조용 바이러스 씨드 스톡에 관한 것이다.
PCT/KR2018/007630 2017-07-05 2018-07-05 인플루엔자 백신용 바이러스 씨드 스톡의 제조 방법, 상기 씨드 스톡을 이용한 인플루엔자 예방 백신의 제조 방법 및 상기 방법에 의해 제조된 바이러스 씨드 스톡 WO2019009640A2 (ko)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201880016526.5A CN110520525B (zh) 2017-07-05 2018-07-05 流感工作病毒种苗与制备、增加其感染力及制备疫苗方法
EA202090042A EA202090042A1 (ru) 2017-07-05 2018-07-05 Способ получения рабочего посевного материала вируса гриппа, способ получения вакцины от гриппа с применением указанного посевного материала и посевной материал вируса, полученный указанным способом
AU2018295867A AU2018295867B2 (en) 2017-07-05 2018-07-05 Method of preparing influenza working virus seed stock, method of preparing influenza vaccine using same seed stock, and virus seed stock prepared by same method
US16/628,228 US11883483B2 (en) 2017-07-05 2018-07-05 Method for preparing influenza working virus seed stock, method for preparing influenza vaccine using same seed stock, and virus seed stock prepared by same method
PE2020000007A PE20201252A1 (es) 2017-07-05 2018-07-05 Metodo para preparar reserva de cepas viricas de trabajo para la influenza, metodo para preparar la vacuna contra la influenza usando la misma reserva de cepas, y la reserva de cepas viricas preparadas por el mismo metodo
BR112019018391A BR112019018391A2 (pt) 2017-07-05 2018-07-05 método de preparação de estoque de agente ativo (seed stock) do vírus influenza, método de preparação de vacina contra influenza utilizando o mesmo estoque de agente ativo (seed stock) e estoque de estoque agente ativo (seed stock) do vírus preparado pelo mesmo
JP2020500146A JP7048716B2 (ja) 2017-07-05 2018-07-05 インフルエンザワクチン用のウイルスシードストックの製造方法、前記シードストックを用いたインフルエンザワクチンの製造方法及び前記方法で製造したウイルスのシードストック
RU2019127445A RU2748577C1 (ru) 2017-07-05 2018-07-05 Способ получения рабочего посевного материала вируса гриппа, способ получения вакцины от гриппа с применением указанного посевного материала и посевной материал вируса, полученный указанным способом
EP18827635.6A EP3650536A4 (en) 2017-07-05 2018-07-05 METHOD FOR PRODUCING INFLUENZA VIRUS STRAIN CULTURE, METHOD FOR PRODUCING INFLUENZA VACCINE USING SUCH STEM CULTURE, AND VIRUS STRAIN CULTURE PRODUCED BY THIS PROCESS
SA519410070A SA519410070B1 (ar) 2017-07-05 2019-09-05 طريقة لتحضير مخزون نواة فيروس إنفلونزا نشط، طريقة لتحضير لقاح إنفلونزا باستخدام مخزون النواة ذاته، ومخزون نواة الفيروس الذي تم تحضيره بواسطة هذه الطريقة
CONC2020/0000021A CO2020000021A2 (es) 2017-07-05 2020-01-03 Método para preparar reserva de cepas víricas de trabajo para la influenza, método para preparar la vacuna contra la influenza usando la misma reserva de cepas, y la reserva de cepas víricas preparadas por el mismo método
PH12020500042A PH12020500042A1 (en) 2017-07-05 2020-01-03 Method for preparing influenza working virus seed stock, method for preparing influenza vaccine using same seed stock, and virus seed stock prepared by same method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170085472A KR102453351B1 (ko) 2017-07-05 2017-07-05 인플루엔자 백신용 바이러스 씨드 스톡의 제조 방법
KR10-2017-0085472 2017-07-05

Publications (2)

Publication Number Publication Date
WO2019009640A2 WO2019009640A2 (ko) 2019-01-10
WO2019009640A3 true WO2019009640A3 (ko) 2019-03-28

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PCT/KR2018/007630 WO2019009640A2 (ko) 2017-07-05 2018-07-05 인플루엔자 백신용 바이러스 씨드 스톡의 제조 방법, 상기 씨드 스톡을 이용한 인플루엔자 예방 백신의 제조 방법 및 상기 방법에 의해 제조된 바이러스 씨드 스톡

Country Status (14)

Country Link
US (1) US11883483B2 (ko)
EP (1) EP3650536A4 (ko)
JP (1) JP7048716B2 (ko)
KR (1) KR102453351B1 (ko)
CN (1) CN110520525B (ko)
AU (1) AU2018295867B2 (ko)
BR (1) BR112019018391A2 (ko)
CO (1) CO2020000021A2 (ko)
EA (1) EA202090042A1 (ko)
PE (1) PE20201252A1 (ko)
PH (1) PH12020500042A1 (ko)
RU (1) RU2748577C1 (ko)
SA (1) SA519410070B1 (ko)
WO (1) WO2019009640A2 (ko)

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CN111440762B (zh) * 2020-04-14 2020-12-04 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种全悬浮mdck细胞和利用全悬浮mdck细胞培养猪流感病毒的方法
KR102444684B1 (ko) * 2020-04-29 2022-09-16 에스케이바이오사이언스(주) 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법

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EA202090042A1 (ru) 2020-04-22
JP7048716B2 (ja) 2022-04-05
KR20190004996A (ko) 2019-01-15
PH12020500042A1 (en) 2020-09-14
AU2018295867A1 (en) 2020-01-30
CN110520525A (zh) 2019-11-29
AU2018295867B2 (en) 2023-10-05
SA519410070B1 (ar) 2022-09-13
EP3650536A4 (en) 2021-04-14
BR112019018391A2 (pt) 2020-04-07
JP2020532283A (ja) 2020-11-12
EP3650536A2 (en) 2020-05-13
US11883483B2 (en) 2024-01-30
RU2748577C1 (ru) 2021-05-27
US20210060153A1 (en) 2021-03-04
WO2019009640A2 (ko) 2019-01-10
CO2020000021A2 (es) 2020-04-13
CN110520525B (zh) 2024-04-16
KR102453351B1 (ko) 2022-10-07
PE20201252A1 (es) 2020-11-16

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