WO2018184795A1

WO2018184795A1 - Device for packaging pharmaceutical portions

Info

Publication number: WO2018184795A1
Application number: PCT/EP2018/056274
Authority: WO
Inventors: Dietmar Gross
Original assignee: Becton Dickinson Rowa Germany Gmbh
Priority date: 2017-04-07
Filing date: 2018-03-13
Publication date: 2018-10-11
Also published as: KR20190134644A; EP3385174A1; BR112019020156A2; CN110536838A; KR102532860B1; CA3056480A1; DK3385174T3; JP7497412B2; EP3385174B1; AU2018249339B2; JP2020516546A; BR112019020156B1; JP2023025121A; AU2018249339A1

Abstract

The invention relates to a device for packaging pharmaceutical portions. In known devices, the packaging or blister-packing process of the pharmaceutical portions is prone to error. In order to solve this problem, the invention provides a device which has a plurality of storage and dispensing stations (10); at least one guide and collecting assembly; a packaging material supply (40); a packaging device (30) with a folding and guiding device (50), said folding and guiding device (50) having a packaging material receiving region (52) with a through-opening (51); a guide device (60) which is arranged above the folding and guiding device (50) and which comprises a receiving section (61) for pharmaceutical portions and a guide section (62) that extends in the direction of the through-opening (51) of the folding and guiding device (50); a first joining device (70) which is arranged downstream of the folding and guiding device (50); and a second joining device (90) which is arranged downstream of the first joining device (70).

Description

Device for packaging medicament portions

The present invention relates to a device for packaging medicament portions and the use

individual components of the device.

Devices for packaging medicament portions, also called blister machines, are known, for example, from US Pat

WO 2013/034504 AI known. The devices comprise, depending on the expansion stage, several hundred storage and dispensing stations, in each of which several drug portions of a particular type of drug are stored. Upon request, individual drug portions may be dispensed from the supply and dispensing stations, which are then fed via a guide means to a packaging device at which the drug portions are packaged. The stored in the supply and delivery stations

Pharmaceutical portions are compiled and blistered individually according to the medically prescribed intake time.

For assembling a plurality of medicament portions, corresponding supply and dispensing stations for dispensing one or more medicament portions are activated by means of a control device of the device. The actual delivery takes place by a stored in a reservoir with a separating device of the supply and dispensing station

Pharmaceutical portion separated and via a discharge opening of a guide means of the device for packaging

Pharmaceutical portions is handed over. By means of

Guide device is the drug portion, regularly with the interposition of a collection device, a

Packaging device supplied which packs or fuses one or more drug portions.

Modern blister machines regularly include a plurality of supply and dispensing stations and also a plurality of collection devices, in which compilations of optionally several drug portions are temporarily stored before they are handed over to the packaging device. Modern blister machines are capable of packaging a large number of drug portion assortments per hour.

In the case of blistering, a packaging material web is moved from a packaging device into a blister tube having a plurality of blister bags arranged one behind the other

reshaped. For this purpose, the packaging device via a

Packaging material feeder a flexible, elongated

Supplied packaging material web. This is folded in the direction of V-shaped and at predetermined intervals across the

Welded direction, with a teilgeschlossener

Blisterbeutel is formed, in which then the

Assignment to medication portions is handed over.

Due to the pretreatment of the packaging material web, the actual receiving area has approximately the shape of a

upturned hollow pyramid.

After the transfer of the partially closed blister bag by welding in the direction of rotation and another

Welding across the running direction (which is also the first

Cross weld for the subsequent blister bag can form) closed.

It has been shown that because of the high

Processing speed, the error rate in the known packaging equipment is too high, over again

Pharmaceutical portions from the only partially closed

Blister bag pop out, especially if several drug portions in a blister bag together

be blistered.

It is the object of the present invention to provide a device for packaging medicament portions, in which the error rate in the actual packaging of the medicament portions in blister packs is reduced.

This object is achieved by a

Apparatus for packaging medicament portions according to Claim 1. The device for packaging drug portions according to the invention comprises a plurality of supply and dispensing stations for dispensing individual medicament portions, at least one guiding and collecting arrangement for receiving and forwarding the from the supply and dispensing stations

delivered drug portions, as well as a

Packaging material feeder for feeding a flexible, elongated packaging material web.

The device according to the invention further comprises a

Packaging device with a folding and guiding device, wherein the folding and guiding device a

Packaging material receiving portion having a through hole and is formed such that the elongated

Packaging material web is fed to the through hole, which in turn is designed such that the elongated

Packaging material web in the direction of one of the

Through-hole defined tubular

Packaging material web is formed with a packaging material overlap region, and arranged above the folding and guiding device guide device with a receiving portion for drug portions and a

Guide portion which extends in the direction of the passage opening of the folding and guiding device and

Medicament portions in the tubular

Packaging material web pipes.

To the by the folding and guiding device

tube-shaped preformed packaging material web

Forming closed blister bags is at the

Device according to the invention one downstream of the folding and

Guiding device arranged first joining device

provided, which assembles the tubular packaging material web in the packaging material overlap region in the running direction of the tubular packaging material, so that a circumferentially closed tube is formed. Furthermore, a downstream of the first joining device arranged second

Joining device provided which the tubular Packaging material web at predetermined intervals, based on the direction of travel, zusammenfügt, so that open at the top

buoyant receiving sections arise. The second

Joining device is regularly designed so that the

Assembly of the packaging material web in approximately orthogonal or transversely to the direction of the packaging material web

is carried out, the exact orientation of the joint is dependent on the desired shape of the blister bag.

In view of the prior art, the handling of the packaging material web and the transfer of the medicament portions according to the invention result in two essential

Differences .

On the one hand, the packaging material web is formed into a differently shaped receiving region, namely an upwardly open, bag-shaped receiving region, so that the risk of the medicament portions jumping out is reduced solely on account of the smaller number of open sides.

On the other hand, the feeding direction of

Pharmaceutical portions when passing in the bag-shaped receiving area another. Due to the design of the preformed partially closed blister bag, it was necessary in the prior art, the packaging material web obliquely, for example, to lead at a 45 ° angle, and the

Then, for example, transfer portions of medication from obliquely upwards into the partially closed blister bag. Due to the design, the feeding direction of the drug portions in the

Recording range always from the direction of the

Packaging material web from. According to the invention, however, it is possible to supply the medicament portions in the receiving area in accordance with the running direction of the packaging material web, since prior to the formation of the individual blister pouches a bag-shaped one

There is a packaging material web section which can be filled from above with drug portions to be restrained.

These two measures mean that even at high processing speeds only a very small error rate in the blistering of the drug portions occurs. The second joining device is designed such that it is suitable for the high desired operating speeds. Periodically a joint substantially transverse to

Can produce direction of travel packaging material web

be stopped, for example, clocked; in the stop time, the packaging material web can then be joined together with suitable joining agents.

Due to the desired high processing speed, however, it is preferred that the packaging material web is not stopped periodically. To realize this, the joining device may, for example, comprise opposing rotating welding rolls with one or more welding means. At which distance then the joints are introduced, depends on several factors, namely the speed of the packaging material web, the rotational speed of the welding rollers and the number of welding agents per welding roller.

The number of blister packs to be blistered

Pharmaceutical portions fluctuates; In order to ensure optimum utilization of the packaging material web, it is desirable to produce blister bags of different lengths. In a preferred embodiment, it is therefore provided that the second joining device comprises a drive device with which the second joining device is movable in and against the running direction of the tubular packaging material web.

In this embodiment, the second joining device in the process of joining the packaging material web with this (transverse to the direction) entrained and after the

Assemble again in the direction of movement. As soon as all of the medicament portions to be introduced are fed to the bag-shaped receiving section, the process of

Reassemble; The length of the blister bag can therefore without changing the running speed of

Packaging material web can be varied by that

Time varies between the individual joining processes.

In the blistering with the known blister machines usually blister tubes with a variety of Blister bags, each containing a collection of drug portions. The blister tubes are usually stored outside the blister machine in roll form. The blisters of a blister hose

optically do not differ, so that a separation after removal from the blister machine is expensive.

In a preferred embodiment, it is therefore

provided that the device for packaging

Pharmaceutical portions a cutting device with a

Cutting means comprises, with which the blister hose at predetermined intervals, based on the direction of travel,

can be severed. How exactly the separation is carried out depends on the exact design of the blister hose. Usually, a transverse joint is part of two

Blisterbeuteln, ie the "lower" end of one and the "upper"

End of another blister hose. A separation then takes place exactly at a joint; If each blister bag has two "own" joints, it can be separated between two joints.

In this embodiment, the blister hose can already be severed during manufacture, a subsequent

Finding the separation point is eliminated. Blister hoses of very different lengths can also be produced without problems with a corresponding device. It is even conceivable to separate the blister bags directly after production.

Also pre-separated Blister hoses include several blister packs, and these blister packs regularly affect several recipes, patients or intake times. A

subsequent separation of the blister bag will therefore be necessary on a regular basis. In a preferred embodiment of

Apparatus for packaging drug portions, the cutting means comprises a plurality of incisors and the

Blister hose and the cutting means are arranged so movable relative to each other, that the blister hose

is severable or perforable. In the embodiment according to the invention, the blister hose can therefore be provided with a component both severed and perforated. So can

For example, patient-specific blister tubes

are produced, the individual blister bag can be easily solved and opened due to the introduced between these perforations. The way of

Distribution separation / perforation can be varied depending on the application.

In a further preferred embodiment, the

Cutting device structurally the second joining device

assigned, so that the separation or perforation can be particularly easily performed, since a precise detection of the part to be separated or perforated is not necessary because the cutting means is carried along with the joining device.

In a particularly preferred embodiment, the second joining device comprises a joining means, in which the

Cutting means is received, in such a way that the joining means extends in the running direction of the packaging material web downstream and upstream of the cutting means. These

Embodiment makes the perforation and cutting particularly simple and accurate, since the separation / perforation always takes place at a joint just made.

The invention further relates to a use of a

Packaging device with a folding and guiding device, which has a packaging material receiving area with a through opening and is formed such that an elongated packaging material web of the through hole

is supplied, which is designed such that the elongated packaging material web in the running direction to one of the

Through-hole defined tubular

Packaging material web is formed with a packaging material overlap region, a arranged above the folding and guiding device guide with a

Receiving section for drug portions and a

Medicament portions in the tubular Packaging material web leads, a first joining device arranged downstream of the folding and guiding device, which the tubular packaging material web at

Packaging material overlap area in the running direction of the tubular packaging material zusammenfügt, as well as a downstream of the first joining device arranged second

Joining device, which the tubular

Packing material web at predetermined intervals, based on the running direction, zusammenfügt, for producing a

Medicament portions of blister tube.

Further preferred embodiments relate to

Use of a packaging device with the additional features described with reference to the device.

Finally, the invention relates to a use of a folding and guiding device for forming a moving in a direction of the packaging material web for producing a drug portions containing Blisterschlauches, wherein the folding and guiding device a

Packaging material receiving area having a through opening and is formed such that an elongated

Packaging material web is fed to the through hole, which is designed such that the elongated

Packaging material web in the direction of one of the

Through-hole defined tubular

Packaging material web is formed with a packaging material overlap region.

Hereinafter, a preferred embodiment of the device according to the invention for the packaging of

Pharmaceutical portions and the use of individual components of this device described with reference to the accompanying drawings, in which:

Figure 1 shows a schematic perspective view of a preferred embodiment of the device according to the invention; Figure 2 is a schematic partial view of

Packaging device in relation to a section of

Guiding and collecting arrangement shows;

Figures 3a - 3d different views of

Show packaging device;

Figure 4 shows a detail view of the packaging device;

Figure 5 is a perspective view of the first

Joining device of the packaging device shows;

Figures 6a - 6b show different perspective views of the second joining device of the packaging device;

Figure 7 is a further detail view of

Packaging device shows;

Figures 8a - 8c further detail views of

Show packaging device, wherein for the better

Illustrating a part of the components of the

Packaging device is omitted;

Figures 9a - 9c show different views of a combination folding and guiding device / guide; and

Figures 10a - 10c different detail views of

Show joining means of the second joining device.

Figure 1 shows a schematic perspective view of an embodiment of the device according to the invention for the packaging of drug portions, the better

For the sake of clarity, a multiplicity of components which are immaterial for the invention as such, for example

Fairing components are omitted. The apparatus 1 comprises a central frame comprising a plurality of vertical struts 2 (only one of which is visible), three horizontal struts 3a, 3b, 3c and a plurality of uprights 4. The lower horizontal strut 3c extends in the

Substantially over the entire length of the device, the upper horizontal struts 3a, 3b extend only in the "right" part of the device.

On the framework, a guiding and collecting arrangement is arranged, which consists in the embodiment shown of a plurality of individual components. The leadership and Collection arrangement comprises three axes 24a, 24b, 24c, which are received in corresponding holes of the horizontal struts 3a, 3b, 3c. The axles 24a, 24b, 24c comprise one (24c), two (24b), or three (24a) pulleys 25, wherein between the pulleys 25 transport belts 22a, 22b, 22c are arranged. The transport belts themselves are according to the arrangement of the axes 24a, 24b, 24c on the different horizontal

Struts of different lengths; The two upper conveyor belts are the same length and form a kind of composite, the lower

Transport belt is correspondingly longer and extends substantially over the entire length of the device.

As can be clearly seen in Figure 1, the guide ^¬ and collection assembly in the illustrated embodiment, two

Main components, wherein the transport belt 22c extends into a region of the device 1, in which the two transport belts 22a, 22b do not extend. These

Dividing two is due to the fact that various components of the guiding and collecting arrangement are arranged on the transport belts 22a, 22b and the transport belt 22c. On or

between the conveyor belts 22a, 22b elongated guide means 20 are arranged on holding means 23, while on the lower conveyor belt 22c on holding means 23rd

Collecting devices 21 are arranged, wherein of the

Guide devices and the collection devices are each shown for the purpose of illustration only a few.

The device 1 comprises a drive 26 with which the axle 24a can be driven, whereby the transport belts 22a, 22b, 22c are moved via the deflection rollers. Because the

Transport belt 22a, 22b and the transport belt 22c are driven via the same axis 24a, they move at the same speed in the direction of rotation. Related to the

Guide means and the collection means means that they are in the area between the axes 24a and 24b at the same speed and aligned with each other in

Direction of rotation can be moved, so that for this path of the synchronous drug portions of a Guidance device in a guided under this

Collection device can be handed over.

In the device for packaging medicament portions, the various medicament portions are arranged in a plurality of supply and dispensing stations 10, of which only a partial matrix is indicated in FIG. These storage and dispensing stations 10 are attached to the device via components (not shown). The stock and

Dispensing stations comprise a storage part in which

Medicament portions are stored, and a dispensing part, via which individual drug portions are transferred on request via a discharge opening in a receiving opening of a guide device. In the embodiment shown, five horizontal rows of storage and dispensing stations are arranged, so that in this case the guide means five

Includes receiving openings over which drug portions can be absorbed.

In operation, the management facilities on the

Transport belt 22a, 22b guided past the storage and dispensing stations 10 and can pass in this

Deliver drug portions of the supply and delivery stations to the guide device, the

Pharmaceutical portions to a arranged under the guide device and in unison with this moving

Handover device. Due to the design of the

Device according to the invention is a guide device so that at all storage and dispensing stations 10 of

Device passed so that each collecting device stored each in the device at each pass

Drug can be supplied.

The inventive device for packaging of

Pharmaceutical portions comprises on the "left" side, on which the transport belts 22a, 22b do not extend, below the conveyor belt 22c, and thus below that on the

Transport belt 22c attached collecting devices 21, a

Packaging device 30 and a packaging material supply 40. About the packaging material supply 40 of the packaging means an elongated packaging material web 41 is supplied. The packaging device 30 forms from the

elongated packaging material web a blister tube 45 having a plurality of blister bags 44, wherein in this transformation drug portions in the collection devices 21st

temporarily stored, to the respectively arising

Blister bag to be handed over. The formation of the blister bag and the transfer of the drug portions in the blister bag will be described with reference to the following figures.

In the embodiment shown, the guiding and collecting arrangement is very complex, but allows a high blinding speed and access to a large number of types of drugs. But there are also much simpler management and collective arrangements conceivable. The

For example, the guiding and collecting arrangement may comprise only one (stationary) collecting device, all of which

Compilations are supplied to drug portions. It is also conceivable that only a guide device is provided, the drug portions of all

Storage and dispensing stations can accommodate.

FIG. 2 shows a schematic partial view of FIG

Packaging device in relation to a section of

Guiding and collecting arrangement. In particular, Figure 2 shows the orientation of the packaging device 30 with respect to a portion of the guiding and collecting arrangement, namely the orientation of a guide 60 of the

Packaging device 30 below the collecting means 21. For the transfer of in a collecting device 21 temporarily

stored drug portions, a dispensing flap 27 of the corresponding aligned collecting device is opened and arranged in the collecting device

Medicament portions fall due to gravity in the

Guide 60, which supplies the actual Verblisterung. FIGS. 3a-3d show different views of the packaging device. This comprises as essential components the guide 60, which compilations of

Pharmaceutical portions of the (not shown)

Collecting facilities assumes. For this purpose, the guide 60 has a receiving portion 61 which is funnel-shaped. The guide 60 further includes a

Guide section, the drug portions in one

Receiving area of the preformed to an open-top Blisterschlauch packaging material web, wherein the

the above-mentioned operation will be described with reference to the following figures.

The folding and guiding device 50, which is described in particular below with reference to FIGS. 5a-5c, runs conically in the center and comprises a central one

Through opening 51, by means of which the supplied

Packaging material web is formed tubular. Roughly, the folding and guiding device has a crater-like configuration, wherein the packaging material web is fed via the outer flanks of the middle.

The packaging device comprises for forming the

separate blister bag having Blisterschlauches a first joining means 70 and a second joining means 90, wherein the first joining means 70, based on the running direction of the packaging material web, downstream of the guide 60 and the second joining means 90 is disposed downstream of the first joining means.

As stated above, with the folding and

Guide means 50 the packaging material web

tube preformed, but is still to the extent of

Hose as well as down and up open. The first, arranged downstream of the guide joining device adds the packaging material web parallel to the direction together, so that a closed tube is formed, which is indicated in Figure 3a below the first joining device with reference numeral 42. Below the first joining device 70 is the second

Joining device 90 is arranged, by means of which the closed tube is joined together transversely to the direction of rotation, it is thus produced with this joining means the bag shape as such. In the embodiment shown, the second joining device 90 is designed such that it can be moved with and against the running direction of the packaging material web. To the

Assembly or insertion of a joint in the

tubular packaging material web 42, the joining means 91a, 91b are moved together. Once the joining agent

moved together, the joining device is moved in the running direction down, the duration of the merge is dependent on the time required for secure assembly. The joint is usually a weld, but other types of assembly are also conceivable.

As soon as the joint has been produced, the joining means are moved apart and the joining device as such is again moved upwards in the direction of travel

"Lower" joint is inserted from above

Pharmaceutical portions are supplied via the guide to the just created receiving area. This

Receiving area is formed after insertion of the joint as open top bag.

When actually introducing the drug portions, the packaging material web is not stopped, but is further moved in the direction of travel, so that this in the

Filling process moved further down. The actual filling or the introduction of drug portions in the

Receiving section, so the open-top preformed

Blister bag, but clocked.

As soon as all medicament portions have been introduced, the joining means 91a, 91b of the second joining device are brought together again and these are replaced with the

Moving the packaging material web downwards, introducing a further joint which at the same time Joint of the blister bag just produced and the "bottom" joint of the subsequently produced

Blister bag is.

The packaging device is associated with a packaging material supply 40, via which the elongated

Packaging material web 41 of the folding and guiding device 50 is supplied (see in particular Figure 3d). The

Packaging material feeder 40 comprises a central one

Packaging material roll 46 and various deflection rollers, which finally supply the elongated packaging material web 41 to the folding and guiding device 50. In the embodiment shown in FIG. 3d, two of the various deflection rollers are coupled to a drive 47. In the embodiment shown, the packaging material supply 40 is a central part of

Packaging device; in other embodiments, the packaging material supply may be external to the actual

Packaging device may be arranged to ensure a rapid change of the packaging material roll.

FIG. 4 shows a detailed view of the packaging device. FIG. 4 shows that in the embodiment shown, the second joining device 90 is a drive unit 100

is assigned, with which of the joining means 91 a, 91 b

comprehensive part of the second joining device can be moved in and against the direction of travel of the packaging material web. FIG. 4 shows that the first joining device 70 comprises two drive belts 74a, 74b which have a drive belt 74a, 74b

Packaging material overlap area 43 encompasses the

due to the special design of the folding and

Guide device is formed. In this

Packaging material overlap region 43 also takes place the actual assembly of the packaging material parallel to the direction of the packaging material, wherein the components used for this purpose are described with reference to the following figures.

FIG. 4 also shows an associated with the joining means 91b

Horizontal adjustment 92 to recognize, with which the joining agent be moved in the X direction on the tubular packaging material web for introducing a joint and after

Insertion of the joint can be removed. With the just-addressed drive unit 100, the second

Joining device in the Y direction in and against the direction of the packaging material web to be moved.

Figure 5 shows a perspective view of the first

Joining device 70 of the packaging device. The first

Joining device comprises a receiving plate 71, on which the folding and joining device is arranged. To assist in the movement of the tubular preformed packaging material web, the first joining means comprises two drive belts 74a, 74b which engage around the packaging material overlap region. From the folding and guiding device is the elongated

Packaging material web preformed tube-shaped and the tubular packaging material overlap area

provided. The actual assembly in the direction takes place in this packaging material overlap area, namely by this overlap area is welded. For this purpose, the first joining device 70 comprises joining means 73a, 73b which rest against the packaging material for joining the latter; to better illustrate the individual components are the

Joining means shown in Figure 5 spaced from each other. The joining means 73a, 73b and the drive belts 74a, 74b are coupled to drives 72a-72c.

FIGS. 6a-6b show two perspective views of the second joining device 90. In order to introduce a joint into the packaging material web, the second joining device 90 comprises two joining means 91a, 91b, which can be moved horizontally. For this purpose, the second joining device comprises two

Horizontal adjustments 92, 93, which can be moved separately. As already described with reference to the aforementioned figures, the section of the second joining device shown in FIGS. 6a, 6b is movable via a drive unit 100 in and against the running direction of the packaging material web. FIG. 7 shows a detailed view of the packaging device in the region of the introduction of the packaging device

Pharmaceutical portions and the joining of the

Packaging material web.

FIG. 7 is in particular the course of FIG

Packaging material web through the first and second

Remove joining device. The folding and guiding device 50 forms the packaging material web into a tubular packaging material web 42 with a packaging material overlap region 43 downstream of the folding and

Guide means by means of the joining means 73a, 73b

is joined, wherein in the illustrated embodiment, a welding of the overlap region takes place. In the second joining device arranged downstream of the first joining device 70

Joining device 90 finds the introduction of the horizontal

Joining instead, in the embodiment shown, a weld is introduced here as well. In detail, the joining means 91a for this purpose comprises two welding edges 94a, 94b which press the packaging material web to be welded during the actual introduction of the welding against two opposing edges 95a, 95b of the joining means 91a. In the embodiment shown, the joining means 91a comprises a cutting means 111, which is embedded centrally in the joining means, such that the welding edges 94a, 94b with respect to the running direction of the

Packaging material web downstream and upstream of the

Cutting means are arranged.

FIGS. 8a-8c show further detail views of FIG

Packaging device, wherein a part of the components of the packaging device is omitted for better illustration. In Figure 8a, the course of the packaging material web with the overlap region 43 can be clearly seen. The second

Joining device 90 is shown in the open position, and below the second joining device 90, the blister hose 45 is indicated as such; the exact guidance of the

Blister tube after making the individual

Blister bag is not shown. In Figure 8b, the packaging material is as such

omitted, and it is the guide portion 62 of

Guiding device 60 which extends through the central passage opening 51 of the folding and guiding device 50, which is illustrated in Figure 8c extends. Of the

Guide portion 62 supports the formation and shaping of the tubular packaging material web and guides the

Pharmaceutical portions to the actual receiving area of the preformed packaging material web, which is located below the guide portion 62. How exactly that

Pharmaceutical portions are introduced into the preformed packaging material web, has already been described with reference to

previous figures described.

Figures 9a - 9c show different views of

Combination folding and guide device / guide. Figure 9a shows the aforementioned combination as shown in the

Packaging device is installed. The guide portion 62 of the guide 60 extends through a central

Through hole 51 of the folding and guiding device 50. In Figure 9b, the guide 60 is vertically displaced with respect to the folding and guiding device 50, in Figure 9c, the two aforementioned components are separate from each other

shown. The shaping of the packaging material web takes place in that it runs up the flanks of the folding and guiding device towards the central passage opening and extends downwards into the latter. In the embodiment shown, the central through-hole 51 of the folding and

Guide device 50 is not closed to the outside, but knows a gap 53, which gap forms the packaging material overlap region 43 during the formation of the packaging material web. An appropriate one

Overlap area could also by other embodiments of the central passage opening or the folding and

Guidance device be provided.

FIGS. 10-10c show detailed views of the area of the

Joining means of the second joining device 90. FIG. 10a shows a Snapshot of the insertion of a joint across the

Running direction of the packaging material web. The joining means 91a comprises a horizontal recess in which a cutting means 111 is arranged. Downstream and upstream of the cutting means, the joining means 91a comprises welding edges 94a, 94b, which with

Counter edges 95a, 95b of the joining agent 91b cooperate. FIG. 10b illustrates the cutting device 110, comprising a cutting means 111 with a plurality of cutting teeth 112. The cutting means 111 as such is connected directly to the horizontal adjustment 93 via several components. The

Joining means 91a is connected via springs 96a, 96b with the aforementioned horizontal adjustment. Moving the

Horizontal adjustment thus moves both the joining agent and the cutting means. But as soon as the joining means 91a is moved over its welding edges to a stop which is regularly provided over the opposite edges 95a, 95b, finds a

Relative movement of the cutting means 111 to the joining means 91a, in that the joining means 91a is pressed into the springs 96a, 96b via the joining means 91b, which is coupled with a horizontal displacement 93 (see FIG. 10c).

During the relative movement of the cutting means 111 to the

Joining means 91b, the cutting means emerges from the receptacle

within the joining means 91a and penetrates into the packaging material web arranged between the joining means. Depending on this relative movement, the

Packaging material web perforated or severed by the incisors. At a low level

Relative movement, the perforation takes place, is the

Joining means 91a further pressed into the springs 96a, 96b via the joining means 91b, finds a severing of the

Packaging material web instead.

Claims

claims

A device (1) for packaging drug portions, comprising

a plurality of supply and dispensing stations (10) for dispensing individual portions of medication,

at least one guiding and collecting arrangement for receiving the dispensed from the storage and dispensing stations (10)

Pharmaceutical portions and forwarding the

Medicament portions,

a packaging material feeder (40) for feeding a flexible, elongated packaging material web (41),

a packaging device (30) with a folding and

Guide device (50), wherein the folding and

Guide means (50) comprises a packaging material receiving portion (52) having a through hole (51) and is formed such that the elongated

Packaging material web (41) of the passage opening (51)

is supplied, which is designed such that the elongated packaging material web (41) in the running direction to one of the through hole (51) defined tubular

Packaging material web (42) is formed with a packaging material overlap region (43),

one above the folding and guiding device (50)

arranged guide device (60) having a medicament portion receiving section (61) and a guide section (62) extending in the direction of the passage opening (51) of the folding and guiding device (50) and guiding medicament portions into the tubular packaging material web (42);

a downstream of the folding and guiding device (50)

arranged first joining device (70), which the

tubular packaging material web (42) during

Packing material overlap area (43) in the running direction of the tubular packaging material together, as well a second joining device (90) arranged downstream of the first joining device (70) and forming the tubular one

Packaging material web (42) at predetermined intervals, based on the running direction, zusammenfügt, so that a continuous blister (45) is formed.

2. Device (1) for packaging medicament portions according to claim 1,

characterized,

in that the second joining device (90) has a

Drive means (100), with which the second

Joining device (90) in and against the direction of the

tubular packaging material web (42) is movable.

3. A device (1) for packaging medicament portions according to claim 1 or 2,

characterized,

in that the device (1) for packaging

Pharmaceutical portions comprises a cutting device (110) with a cutting means (111), with which the blister tube (45) at predetermined intervals, based on the direction of travel, can be severed.

4. The device (1) for packaging medicament portions according to claim 3,

characterized,

the cutting means (111) comprises a plurality of

Cutting teeth (112) and that the blister hose (42) and the cutting means (111) are arranged so movable relative to each other that the blister (42) is severable or perforable.

5. Device (1) for packaging medicament portions according to one of claims 3 or 4,

characterized, that the cutting device (110) structurally the second

Joining device (90) is assigned.

6. Device (1) for packaging medicament portions according to one of claims 3 - 5,

characterized,

in that the second joining device (90) comprises a joining means (91a) in which the cutting means (111) is received.

7. Use of a packaging device (30) with

a folding and guiding device (50), wherein the folding and guiding device (50) has a packaging material receiving area (52) with a passage opening (51) and is designed such that an elongate

Packaging material web (41) of the passage opening (51)

a guide device (60) arranged above the folding and guiding device (50) with a medicament portion receiving section (61) and a guide section (62) extending in the direction of the passage opening (51) of the folding and guiding device (50) and medicament portions into the tubular packaging material web (42),

a downstream of the folding and guiding device (50)

arranged first joining device (70), which the

tubular packaging material web (42) during

Packing material overlap area (43) in the running direction of the tubular packaging material together, as well

a downstream of the first joining means (70) arranged second joining means (90), which the tubular

Packaging material web (42) at predetermined intervals, based on the direction of running, zusammenfügt, for producing a medicine portion

Blister hose (45).

8. Use of a packaging device (30) for

Producing a portion of medicament containing

Blister hose (45) according to claim 7,

characterized,

in that the second joining device (90) has a

Drive means (100), with which the second

Joining device (90) in and against the direction of the

tubular packaging material web (42) is movable.

9. Use of a packaging device (30) for

Producing a portion of medicament containing

Blister hose (45) according to claim 7 or 8,

characterized,

in that the device (1) for packaging

Pharmaceutical portions comprises a cutting device (110) with a cutting means (111), with which the blister tube at predetermined intervals, based on the direction of travel,

can be severed.

10. Use of a packaging device (30) for

Producing a portion of medicament containing

Blister hose (45) according to claim 9,

characterized,

the cutting means (111) comprises a plurality of

Contains cutting teeth (112) and is movable so that the blister tube is severable or perforable.

11. Use of a packaging device (30) for

Producing a portion of medicament containing

Blister hose (45) according to claim 9 or 10,

characterized,

that the cutting device (110) structurally the second

Joining device (90) is assigned.

12. Use of a packaging device (30) for

Producing a portion of medicament containing

Blister hose (45) according to any one of claims 9 - 11,

characterized in that the second joining device (90) comprises a joining means (91a) in which the cutting means (111) is received.

13. Use of a folding and guiding device (50) for forming a moving in a running direction

Packaging material web for producing a

Blister hose containing drug portions, wherein the folding and guiding device (50) has a packaging material receiving area (52) with a through hole (51) and is formed such that an elongated

Packaging material web (41) of the passage opening (51)

Packaging material web (42) with a packaging material overlap region (43) is formed.