EP3385174B1 - Device for packaging drug portions - Google Patents

Device for packaging drug portions Download PDF

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Publication number
EP3385174B1
EP3385174B1 EP17165405.6A EP17165405A EP3385174B1 EP 3385174 B1 EP3385174 B1 EP 3385174B1 EP 17165405 A EP17165405 A EP 17165405A EP 3385174 B1 EP3385174 B1 EP 3385174B1
Authority
EP
European Patent Office
Prior art keywords
packaging material
packaging
material web
joining
drug portions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17165405.6A
Other languages
German (de)
French (fr)
Other versions
EP3385174A1 (en
Inventor
Dietmar Gross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson Rowa Germany GmbH
Original Assignee
Becton Dickinson Rowa Germany GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP17165405.6A priority Critical patent/EP3385174B1/en
Application filed by Becton Dickinson Rowa Germany GmbH filed Critical Becton Dickinson Rowa Germany GmbH
Priority to DK17165405T priority patent/DK3385174T3/en
Priority to KR1020197029406A priority patent/KR102532860B1/en
Priority to CA3056480A priority patent/CA3056480A1/en
Priority to JP2019554983A priority patent/JP2020516546A/en
Priority to CN201880023514.5A priority patent/CN110536838A/en
Priority to PCT/EP2018/056274 priority patent/WO2018184795A1/en
Priority to BR112019020156-4A priority patent/BR112019020156B1/en
Priority to AU2018249339A priority patent/AU2018249339B2/en
Publication of EP3385174A1 publication Critical patent/EP3385174A1/en
Application granted granted Critical
Publication of EP3385174B1 publication Critical patent/EP3385174B1/en
Priority to JP2022189400A priority patent/JP7497412B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/10—Applying or generating heat or pressure or combinations thereof
    • B65B51/26—Devices specially adapted for producing transverse or longitudinal seams in webs or tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/04—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for severing webs, or for separating joined packages
    • B65B61/06—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for severing webs, or for separating joined packages by cutting
    • B65B61/10—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for severing webs, or for separating joined packages by cutting using heated wires or cutters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/10—Enclosing successive articles, or quantities of material, in preformed tubular webs, or in webs formed into tubes around filling nozzles, e.g. extruded tubular webs
    • B65B9/20—Enclosing successive articles, or quantities of material, in preformed tubular webs, or in webs formed into tubes around filling nozzles, e.g. extruded tubular webs the webs being formed into tubes in situ around the filling nozzles
    • B65B9/22—Forming shoulders; Tube formers
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F17/00—Coin-freed apparatus for hiring articles; Coin-freed facilities or services
    • G07F17/0092—Coin-freed apparatus for hiring articles; Coin-freed facilities or services for assembling and dispensing of pharmaceutical articles

Definitions

  • the present invention relates to a device for packaging medicament portions and the use of individual components of the device.
  • Devices for packaging medicament portions are known, for example, from US Pat WO 2013/034504 A1 known.
  • the devices comprise, depending on the expansion stage, several hundred storage and dispensing stations, in each of which several drug portions of a particular type of drug are stored.
  • individual drug portions may be dispensed from the supply and dispensing stations, which are then fed via a guide means to a packaging device at which the drug portions are packaged.
  • the medicament portions stored in the storage and dispensing stations are compiled and blistered according to the individual patient's intake in accordance with the prescribed medication.
  • corresponding supply and dispensing stations for dispensing one or more medicament portions are activated by means of a control device of the device.
  • the actual delivery takes place by separating a medicament portion stored in a storage container with a separating device of the storage and dispensing station and transferring it via a dispensing opening to a guide device of the device for packaging medicament portions.
  • the guide device By means of the guide device, the medicament portion is fed, regularly with the interposition of a collecting device, to a packaging device which packages or fuses one or more medicament portions.
  • Modern blister machines regularly include a plurality of supply and dispensing stations and also a plurality of collection devices, in which compilations of optionally several drug portions are temporarily stored before they are handed over to the packaging device.
  • Modern blister machines are capable of packaging a large number of drug portion assortments per hour.
  • a packaging material web is converted from a packaging device into a blister tube having a multiplicity of blister bags arranged one behind the other.
  • the packaging device is supplied via a packaging material supply a flexible, elongated packaging material web. This is folded in the direction V-shaped and welded at predetermined intervals transversely to the direction, with a partially closed blister bag is formed, in which then the compilation is handed over to drug portions. Due to the pretreatment of the packaging material web, the actual receiving area has approximately the shape of an inverted hollow pyramid.
  • the partially closed blister bag is closed by welding in the direction of travel and another welding transversely to the direction of travel (which can also form the first transverse weld for the subsequent blister bag).
  • the device for packaging medicament portions according to Claim 1 comprises a plurality of supply and dispensing stations for dispensing individual medicament portions, at least one guiding and collecting arrangement for receiving and conveying the medicament portions dispensed from the supply and dispensing stations, and a packaging material supply for feeding a flexible, elongated packaging material web.
  • the device according to the invention further comprises a packaging device with a folding and guiding device, wherein the folding and guiding device has a packaging material receiving area with a through opening and is designed such that the elongated packaging material web is fed to the through opening, which in turn is designed such that the elongated packaging material web is formed in the running direction to a defined by the passage opening tubular packaging material web with a packaging material overlap region, and arranged above the folding and guide device guide with a receiving portion for drug portions and a guide portion extending in the direction of the passage opening of the folding and guiding device extends and drug delivery leads into the tubular packaging material web.
  • a first joining device arranged downstream of the folding and guiding device is provided in the device according to the invention, which joins the tubular packaging material web in the packaging material overlap region in the running direction of the tubular packaging material that a circumferentially closed hose is formed. Furthermore, a second joining device arranged downstream of the first joining device is provided, which connects the tubular one Packaging material web at predetermined intervals, based on the direction of travel, fauxhex, so that upwardly open bag-shaped receiving portions arise.
  • the second joining device is regularly designed such that the assembly of the packaging material web is performed approximately orthogonally or transversely to the direction of travel of the packaging material web, wherein the exact alignment of the joint depends on the shape of the blister bag to be achieved.
  • the packaging material web is formed into a differently shaped receiving region, namely an upwardly open bag-shaped receiving region, so that the risk of a jump-out of medicament portions is reduced solely due to the smaller number of open sides.
  • the direction of delivery of the medicament portions when transferring into the bag-shaped receiving area is different. Due to the configuration of the preformed partially closed blister bag, it was necessary in the prior art, the packaging material web obliquely, for example, to lead at a 45 ° angle, and then transfer the drug portions, for example, obliquely from above into the partially closed blister. Due to the design, the feeding direction of the medicament portions in the receiving area always deviated from the running direction of the packaging material web.
  • the second joining device is designed such that it is suitable for the high desired operating speeds. To periodically produce a joint substantially transverse to the direction of packaging material web can be stopped, for example, clocked; in the stop time, the packaging material web can then be joined together with suitable joining agents.
  • the packaging material web is not stopped periodically.
  • the joining device may, for example, comprise opposing rotating welding rolls with one or more welding means. At which distance then the joints are introduced, depends on several factors, namely the speed of the packaging material web, the rotational speed of the welding rollers and the number of welding agents per welding roller.
  • the second joining device comprises a drive device with which the second joining device is movable in and against the running direction of the tubular packaging material web.
  • the second joining device in the process of assembling the packaging material web, is carried along with it (transversely to the running direction) and, after assembly, is again moved counter to the running direction. Once all the drug portions to be introduced are supplied to the bag-shaped receiving portion, the process of assembly begins again; The length of the blister bag can thus be varied without changing the running speed of the packaging material web, that the time between the individual joining operations is varied.
  • blister tubes with a variety of Blister bags, each containing a collection of drug portions.
  • the blister tubes are usually stored outside the blister machine in roll form.
  • the blister packs of a blister hose do not virtually differ visually, so that a separation after removal from the blister machine is complicated.
  • the device for packaging medicament portions comprises a cutting device with a cutting means, with which the blister tube at predetermined intervals, based on the direction of travel, can be severed. How exactly the separation is carried out depends on the exact design of the blister hose. Usually, a transverse joint is part of two blister bags, ie the "lower” end of one and the “upper” end of another blister hose. A separation then takes place exactly at a joint; If each blister bag has two "own” joints, it can be separated between two joints.
  • the blister hose can already be severed during manufacture, a subsequent finding of the separation point is eliminated. Blister hoses of very different lengths can also be produced without problems with a corresponding device. It is even conceivable to separate the blister bags directly after production.
  • pre-separated Blister hoses include several blister packs, and these blister packs regularly affect several recipes, patients or intake times. Subsequent separation of the blister bag will therefore be necessary on a regular basis.
  • the cutting means comprises a plurality of incisors, and the blister tube and the cutting means are arranged to be movable relative to one another such that the blister tube is severable or pierceable.
  • the blister hose can therefore be provided with a component both severed and perforated.
  • patient-specific blister tubes can be produced, the individual blister bags can be easily solved and opened from each other due to the introduced between these perforation.
  • the way of distribution separation / perforation can be varied depending on the application.
  • the cutting device is structurally associated with the second joining device, so that the separation or perforation can be carried out particularly simply, since an exact detection of the point to be separated or perforated is not necessary, since the cutting means is carried along with the joining device ,
  • the second joining device comprises a joining means, in which the cutting means is accommodated, in such a way that the joining means extends in the running direction of the packaging material web downstream and upstream of the cutting means.
  • the invention further relates to a use of a packaging device with a folding and guiding device, which has a packaging material receiving area with a through opening and is designed such that an elongated packaging material web is fed to the through opening, which is designed such that the elongated packaging material web in the running direction to a tubular packaging material web defined by the through-opening is formed with a packaging material overlap region, a guide arranged above the folding and guiding device with a portion for drug portions and a guide portion which extends in the direction of the passage opening of the folding and guiding device and drug portions in the tubular
  • the packaging material web leads, a first joining device arranged downstream of the folding and guiding device, which assembles the tubular packaging material web in the packaging material overlap region in the running direction of the tubular packaging material, and a second joining device arranged downstream of the first joining device, which feeds the tubular packaging material web at predetermined intervals relative to the Running direction, fauxhegt, for producing a drug portions containing blister tube.
  • the invention relates to a use of a folding and guiding device for forming a moving in a direction of packaging material web for producing a drug portions containing Blisterschlauches, wherein the folding and guiding means comprises a packaging material receiving portion having a through hole and is formed such that an elongated packaging material web is supplied to the through hole, which is designed such that the elongated packaging material web is formed in the running direction to a defined by the passage opening tubular packaging material web with a packaging material overlap region.
  • FIG. 1 shows a schematic perspective view of an embodiment of the device according to the invention for the packaging of medicament portions, for the sake of clarity, a plurality of for the invention as such unessential components, such as cladding components, are omitted.
  • the apparatus 1 comprises a central frame comprising a plurality of vertical struts 2 (only one of which is visible), three horizontal struts 3a, 3b, 3c and a plurality of struts 4.
  • the lower horizontal strut 3c extends substantially the entire length of the struts Device, the upper horizontal struts 3a, 3b extend only in the "right" part of the device.
  • a guiding and collecting arrangement is arranged, which consists in the embodiment shown of a plurality of individual components.
  • the leadership and Collection arrangement comprises three axes 24a, 24b, 24c, which are received in corresponding holes of the horizontal struts 3a, 3b, 3c.
  • the axles 24a, 24b, 24c comprise one (24c), two (24b), or three (24a) pulleys 25, wherein between the pulleys 25 transport belts 22a, 22b, 22c are arranged.
  • the transport belts themselves are different in length according to the arrangement of the axes 24a, 24b, 24c on the different horizontal struts; the two upper conveyor belts are the same length and form a kind of composite, the lower conveyor belt is correspondingly longer and extends substantially over the entire length of the device.
  • This division into two parts is based on the fact that different components of the guiding and collecting arrangement are arranged on the transport belts 22a, 22b and the transport belt 22c.
  • elongated guide means 20 are arranged on holding means 23, while collecting means 21 are arranged on holding means 23 on the lower conveyor belt 22c, only a few of the guide means and the collecting means being shown for the purpose of illustration.
  • the device 1 comprises a drive 26 with which the axle 24a can be driven, whereby the transport belts 22a, 22b, 22c are moved via the deflection rollers. Since the transport belts 22a, 22b and the transport belt 22c are driven via the same axis 24a, they move at the same speed in the direction of rotation. With respect to the guide means and the collection means this means that they can be moved in the area between the axes 24a and 24b at the same speed and aligned with each other in the direction of rotation, so that for this path of the synchronous drug portions of a Guide device can be transferred to a guided under this collector.
  • the various drug portions are arranged in a plurality of supply and dispensing stations 10, of which in illustration 1 only a partial matrix is indicated.
  • These storage and dispensing stations 10 are attached to the device via components (not shown).
  • the storage and dispensing stations comprise a storage part, in which medicament portions are stored, and a dispensing part, via which individual medicament portions are transferred on request via a dispensing opening into a receiving opening of a guide device.
  • five horizontal rows of storage and dispensing stations are arranged, so that in this case the guide device comprises five receiving openings, via which medicament portions can be received.
  • the guide means are passed over the transport belts 22a, 22b to the supply and dispensing stations 10, and during this passage medicament portions can be dispensed from the supply and dispensing stations to the guide means, which align the drug portions with one below the guide means and in unison with this moving collecting device passes. Due to the construction of the device according to the invention, a guide device is thus guided past all the supply and delivery stations 10 of the device, so that each collection device can be supplied with each type of drug stored in the device during each run.
  • the device for packaging medicament portions comprises on the "left" side, on which the transport belts 22a, 22b do not extend, below the transport belt 22c, and thus below the collecting devices 21 fastened to the transport belt 22c, a packaging device 30 and a packaging material. feed 40.
  • About the packaging material supply 40 of the packaging means an elongated packaging material web 41 is supplied.
  • the packaging device 30 forms from the elongated packaging material web a blister tube 45 with a plurality of blister bags 44, wherein during this transformation medicament portions, which are temporarily stored in the collection devices 21, are transferred to the respective blister bags.
  • the formation of the blister bag and the transfer of the drug portions in the blister bag will be described with reference to the following figures.
  • the guiding and collecting arrangement is very complex, but allows a high blinding speed and access to a large number of types of drugs. But there are also much simpler management and collective arrangements conceivable.
  • the guiding and collecting arrangement may comprise only one (stationary) collecting device, to which all compositions of medicament portions are supplied. It is also conceivable that only a guide means is provided which can receive drug portions of all supply and dispensing stations.
  • FIG. 2 shows a schematic partial view of the packaging device in relation to a portion of the guiding and collecting arrangement.
  • the orientation of the packaging device 30 with respect to a portion of the guiding and collecting arrangement namely the orientation of a guide 60 of the packaging device 30 below the collecting means 21.
  • drug portions a dispensing flap 27 of the corresponding aligned collecting device opened and arranged in the collection drug portions fall by gravity in the guide 60, which feeds the actual Verblist für
  • FIGS. 3a-3d show different views of the packaging device.
  • the guiding device 60 which takes over assemblies of medicament portions from the collecting devices (not shown).
  • the guide 60 has a receiving portion 61 which is funnel-shaped.
  • the guide device 60 further comprises a guide section, which feeds drug portions into a receiving area of the packaging material web preformed to an open-top blister tube, the aforementioned process being described with reference to the following figures.
  • the folding and guiding device 50 which in particular below with reference to the FIGS. 5a-5c is described conically at the center and comprises a central passage opening 51, by means of which the supplied packaging material web is formed tubular. Roughly, the folding and guiding device has a crater-like configuration, wherein the packaging material web is fed via the outer flanks of the middle.
  • the packaging device comprises a first joining device 70 and a second joining device 90 for forming the blister bag having the separate blister bag, the first joining device 70 being located downstream of the guide 60 and the second joining device 90 downstream of the first joining device, with respect to the running direction of the packaging material web.
  • the packaging material web is preformed tube-shaped, but is still open to the circumference of the tube and downwards and upwards.
  • the first, arranged downstream of the guide joining device adds the packaging material web parallel to the direction, so that a closed tube is formed in FIG. 3a below the first joining device is indicated by reference numeral 42.
  • the second joining device 90 is arranged, by means of which the closed tube is joined transversely to the direction of rotation, it is thus produced with this joining means the bag shape as such.
  • the second joining device 90 is designed such that it can be moved with and against the running direction of the packaging material web.
  • the joining means 91a, 91b are moved together. Once the joining means have moved together, the joining device is moved downwards in the running direction, the duration of the merging being dependent on the time required for secure joining.
  • the joint is usually a weld, but other types of assembly are also conceivable.
  • the joining means are moved apart and moved the joining device as such again against the direction "up".
  • medicament portions can be supplied from above via the guide device to the receiving region just created. This receiving area is formed after insertion of the joint as open top bag.
  • the packaging material web is not stopped, but is moved further in the running direction, so that it continues to move downwards during the filling process.
  • the actual filling or the introduction of drug portions in the receiving portion so the open-top preformed blister, but clocked.
  • the joining means 91a, 91b of the second joining device are again brought together and the latter moved downwards with the packaging material web, whereby a further joint is introduced, which simultaneously produces the "upper” Joint of the blister bag just made and the "bottom” joint of the subsequently produced Blister bacterias is.
  • the packaging device is associated with a packaging material feed 40, via which the elongated packaging material web 41 of the folding and guiding device 50 is supplied (see in particular 3d figure ).
  • the packaging material feed 40 comprises a central packaging material roll 46 and various deflection rollers, which finally supply the elongate packaging material web 41 to the folding and guiding device 50.
  • two of the various pulleys are coupled to a drive 47.
  • the packaging material supply 40 is a central component of the packaging device; in other embodiments, the packaging material supply may be disposed outside of the actual packaging device to ensure a rapid change of the packaging material roll.
  • FIG. 4 shows a detailed view of the packaging device.
  • the second joining device 90 is associated with a drive unit 100 with which the part of the second joining device comprising the joining means 91a, 91b can be moved in and against the running direction of the packaging material web.
  • the first joining device 70 comprises two drive belts 74a, 74b, which encompasses a packaging material overlapping region 43, which is formed on account of the special configuration of the folding and guiding device. In this packaging material overlap region 43, the actual assembly of the packaging material takes place parallel to the running direction of the packaging material, wherein the components used for this purpose are described with reference to the following figures.
  • FIG. 4 Furthermore, a horizontal adjustment 92 assigned to the joining means 91b can be seen, with which the joining means can be moved in the X direction on the tubular packaging material web for introducing a joint and can be removed after introduction of the joint.
  • the second joining device can be moved in the Y direction in and against the running direction of the packaging material web.
  • FIG. 5 shows a perspective view of the first joining means 70 of the packaging device.
  • the first joining device comprises a receiving plate 71 on which the folding and joining device is arranged.
  • the first joining means comprises two drive belts 74a, 74b which engage around the packaging material overlap region.
  • the first joining device 70 comprises joining means 73a, 73b which rest against the packaging material for joining the latter; to better illustrate the individual components, the joining means in FIG. 5 spaced apart from each other.
  • the joining means 73a, 73b and the drive belts 74a, 74b are coupled to drives 72a-72c.
  • FIGS. 6a - 6b show two perspective views of the second joining device 90.
  • the second joining means 90 comprises two joining means 91a, 91b, which can be moved horizontally.
  • the second joining device comprises two horizontal displacements 92, 93, which can be moved separately from one another.
  • FIGS. 6a, 6b shown portion of the second joining device via a drive unit 100 in and against the direction of travel of the packaging material web movable.
  • FIG. 7 shows a detailed view of the packaging device, in the area of the introduction of the drug portions and the joining of the packaging material web.
  • FIG. 7 the course of the packaging material web can be seen through the first and second joining device.
  • the folding and guiding device 50 forms the packaging material web into a tubular packaging material web 42 having a packaging material overlap region 43 which is joined downstream of the folding and guiding device by means of the joining means 73a, 73b, wherein welding of the overlapping region occurs in the illustrated embodiment.
  • the second joining device 90 arranged downstream of the first joining device 70, the introduction of the horizontal joints takes place, with a weld also being introduced here in the embodiment shown.
  • the joining means 91a for this purpose comprises two welding edges 94a, 94b which press the packaging material web to be welded during the actual introduction of the welding against two opposing edges 95a, 95b of the joining means 91a.
  • the joining means 91a comprises a cutting means 111, which is embedded centrally in the joining means, such that the welding edges 94a, 94b are arranged downstream and upstream of the cutting means with respect to the running direction of the packaging material web.
  • FIGS. 8a-8c show further detail views of the packaging device, wherein a part of the components of the packaging device is omitted for better illustration.
  • FIG. 8a the course of the packaging material web with the overlap region 43 can be clearly seen.
  • the second joining device 90 is shown in the open position, and below the second joining device 90, the blister hose 45 is indicated as such; the exact guidance of the blister after making the individual blister bag is not shown.
  • FIG. 8b is omitted as the packaging material, and it is the guide portion 62 of the guide 60 can be seen, extending through the central through hole 51 of the folding and guiding device 50, which in FIG. 8c is illustrated extends.
  • the guide section 62 assists in the formation and shaping of the tubular packaging material web and delivers the medicament portions to the actual receiving region of the preformed packaging material web, which is located below the guide section 62. How exactly the medicament portions are introduced into the preformed packaging material web has already been described with reference to the preceding figures.
  • FIGS. 9a-9c show different views of the combination folding and guide device / guide.
  • FIG. 9a shows the aforementioned combination as it is installed in the packaging device.
  • the guide portion 62 of the guide 60 extends through a central through hole 51 of the folding and guiding device 50.
  • Bei FIG. 9b the guide 60 is displaced vertically with respect to the folding and guiding device 50 at FIG. 9c the two aforementioned components are shown separately from each other.
  • the shaping of the packaging material web takes place in that it runs up the flanks of the folding and guiding device towards the central passage opening and extends downwards into the latter.
  • the central through-opening 51 of the folding and guiding device 50 is not closed to the outside, but has a gap 53, this gap forming the packaging material overlapping area 43 during the formation of the packaging material web.
  • a corresponding overlapping region could also be provided by other embodiments of the central through-opening or the folding and guiding device.
  • FIG. 10a shows one Snapshot of the introduction of a joint transverse to the direction of the packaging material web.
  • the joining means 91a comprises a horizontal recess in which a cutting means 111 is arranged. Downstream and upstream of the cutting means, the joining means 91a comprises welding edges 94a, 94b which cooperate with counter edges 95a, 95b of the joining means 91b.
  • FIG. 10b 1 illustrates the cutting device 110, comprising a cutting means 111 having a plurality of cutting teeth 112. The cutting means 111 as such is directly connected to the horizontal adjustment 93 via a plurality of components.
  • the joining means 91a is connected via springs 96a, 96b with the aforementioned horizontal adjustment. Moving the horizontal adjustment thus moves both the joining means and the cutting means. However, as soon as the joining means 91a is moved over its welding edges to a stop which is regularly provided over the opposite edges 95a, 95b, a relative movement of the cutting means 111 to the joining means 91a takes place, by the joining means 91a via the joining means 91b, which with a horizontal adjustment 93 is coupled, is pressed in the springs 96a, 96b (see FIG. 10c ).
  • the cutting means 111 During the relative movement of the cutting means 111 to the joining means 91b, the cutting means emerges from the receptacle within the joining means 91a and penetrates into the packaging material web arranged between the joining means.
  • the packaging material web can be perforated or severed by means of the incisors. If there is only a slight relative movement, the perforation takes place; if the joining means 91a is pushed further into the springs 96a, 96b via the joining means 91b, the packaging material web is severed.

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Description

Die vorliegende Erfindung betrifft eine Vorrichtung zum Verpacken von Arzneimittelportionen sowie die Verwendung einzelner Bauteile der Vorrichtung.The present invention relates to a device for packaging medicament portions and the use of individual components of the device.

Vorrichtungen zum Verpacken von Arzneimittelportionen, auch Blisterautomaten genannt, sind beispielsweise aus der WO 2013/034504 A1 bekannt. Die Vorrichtungen umfassen, je nach Ausbaustufe, mehrere hundert Vorrats- und Abgabestationen, in welchen jeweils mehrere Arzneimittelportionen eines bestimmten Arzneimitteltyps gelagert sind. Auf Anforderung können einzelne Arzneimittelportionen von den Vorrats- und Abgabestationen abgegeben werden, welche dann über eine Führungseinrichtung einer Verpackungseinrichtung zugeführt werden, bei welcher die Arzneimittelportionen verpackt bzw. verblistert werden. Die in den Vorrats- und Abgabestationen gelagerten Arzneimittelportionen werden patientenindividuell gemäß den ärztlich verordneten Einnahmezeitpunkten zusammengestellt und verblistert.Devices for packaging medicament portions, also called blister machines, are known, for example, from US Pat WO 2013/034504 A1 known. The devices comprise, depending on the expansion stage, several hundred storage and dispensing stations, in each of which several drug portions of a particular type of drug are stored. Upon request, individual drug portions may be dispensed from the supply and dispensing stations, which are then fed via a guide means to a packaging device at which the drug portions are packaged. The medicament portions stored in the storage and dispensing stations are compiled and blistered according to the individual patient's intake in accordance with the prescribed medication.

Zum Zusammenstellen mehrerer Arzneimittelportionen werden entsprechende Vorrats- und Abgabestationen zur Abgabe einer oder mehrerer Arzneimittelportionen mittels einer Steuereinrichtung der Vorrichtung angesteuert. Die eigentliche Abgabe findet statt, indem mit einer Vereinzelungseinrichtung der Vorrats- und Abgabestation eine in einem Vorratsbehälter gelagerte Arzneimittelportion separiert und über eine Abgabeöffnung einer Führungseinrichtung der Vorrichtung zum Verpacken von Arzneimittelportionen übergeben wird. Mittels der Führungseinrichtung wird die Arzneimittelportion, regelmäßig unter Zwischenschaltung einer Sammeleinrichtung, einer Verpackungseinrichtung zugeführt, welche einzelne oder mehrere Arzneimittelportionen verpackt bzw. verblistert.For assembling a plurality of medicament portions, corresponding supply and dispensing stations for dispensing one or more medicament portions are activated by means of a control device of the device. The actual delivery takes place by separating a medicament portion stored in a storage container with a separating device of the storage and dispensing station and transferring it via a dispensing opening to a guide device of the device for packaging medicament portions. By means of the guide device, the medicament portion is fed, regularly with the interposition of a collecting device, to a packaging device which packages or fuses one or more medicament portions.

Moderne Blisterautomaten umfassen regelmäßig eine Vielzahl von Vorrats- und Abgabestationen und ebenfalls eine Vielzahl von Sammeleinrichtungen, in welchen Zusammenstellungen von gegebenenfalls mehreren Arzneimittelportionen temporär gelagert werden, bevor sie an die Verpackungseinrichtung übergeben werden. Moderne Blisterautomaten sind in der Lage, eine große Anzahl von Zusammenstellungen von Arzneimittelportionen pro Stunde zu verpacken bzw. zu verblistern.Modern blister machines regularly include a plurality of supply and dispensing stations and also a plurality of collection devices, in which compilations of optionally several drug portions are temporarily stored before they are handed over to the packaging device. Modern blister machines are capable of packaging a large number of drug portion assortments per hour.

Bei der Verblisterung wird eine Verpackungsmaterialbahn von einer Verpackungseinrichtung in einen Blisterschlauch mit einer Mehrzahl von hintereinander angeordneten Blisterbeuteln umgeformt. Dazu wird der Verpackungseinrichtung über eine Verpackungsmaterial-Zuführung eine flexible, längliche Verpackungsmaterialbahn zugeführt. Diese wird in Laufrichtung V-förmig gefaltet und in vorgegebenen Abständen quer zur Laufrichtung verschweißt, wobei ein teilgeschlossener Blisterbeutel gebildet wird, in welchen dann die Zusammenstellung an Arzneimittelportionen übergeben wird. Bedingt durch die Vorbehandlung der Verpackungsmaterialbahn hat der eigentliche Aufnahmebereich annähernd die Form einer umgedrehten hohlen Pyramide.In the case of blistering, a packaging material web is converted from a packaging device into a blister tube having a multiplicity of blister bags arranged one behind the other. For this purpose, the packaging device is supplied via a packaging material supply a flexible, elongated packaging material web. This is folded in the direction V-shaped and welded at predetermined intervals transversely to the direction, with a partially closed blister bag is formed, in which then the compilation is handed over to drug portions. Due to the pretreatment of the packaging material web, the actual receiving area has approximately the shape of an inverted hollow pyramid.

Nach der Übergabe wird der teilgeschlossene Blisterbeutel durch ein Verschweißen in Laufrichtung und eine weitere Verschweißung quer zur Laufrichtung (die auch die erste Querverschweißung für den nachfolgenden Blisterbeutel bilden kann) verschlossen.After the transfer, the partially closed blister bag is closed by welding in the direction of travel and another welding transversely to the direction of travel (which can also form the first transverse weld for the subsequent blister bag).

Es hat sich gezeigt, dass aufgrund der hohen Verarbeitungsgeschwindigkeit die Fehlerquote bei den bekannten Verpackungseinrichtungen zu hoch ist, da immer wieder Arzneimittelportionen aus dem lediglich teilgeschlossenen Blisterbeutel herausspringen, insbesondere dann, wenn mehrere Arzneimittelportionen in einem Blisterbeutel zusammen verblistert werden.It has been shown that due to the high processing speed, the error rate in the known packaging devices is too high, as again and again drug portions jump out of the only partially closed blister bag, especially if several drug portions are blistered together in a blister bag.

Es ist Aufgabe der vorliegenden Erfindung, eine Vorrichtung zum Verpacken von Arzneimittelportionen bereitzustellen, bei welcher die Fehlerquote bei der eigentlichen Verpackung der Arzneimittelportionen in Blisterbeutel vermindert ist.It is the object of the present invention to provide a device for packaging medicament portions, in which the error rate in the actual packaging of the medicament portions in blister packs is reduced.

Diese Aufgabe wird erfindungsgemäß gelöst durch eine Vorrichtung zum Verpacken von Arzneimittelportionen gemäß Patentanspruch 1. Die erfindungsgemäße Vorrichtung zum Verpacken von Arzneimittelportionen umfasst eine Mehrzahl von Vorrats- und Abgabestationen zum Abgeben einzelner Arzneimittelportionen, zumindest eine Führungs- und Sammelanordnung zum Aufnehmen und Weiterleiten der von den Vorrats- und Abgabestationen abgegebenen Arzneimittelportionen, sowie eine Verpackungsmaterial-Zuführung zum Zuführen einer flexiblen, länglichen Verpackungsmaterialbahn.This object is achieved by a device for packaging medicament portions according to Claim 1. The device for packaging medicament portions according to the invention comprises a plurality of supply and dispensing stations for dispensing individual medicament portions, at least one guiding and collecting arrangement for receiving and conveying the medicament portions dispensed from the supply and dispensing stations, and a packaging material supply for feeding a flexible, elongated packaging material web.

Die erfindungsgemäße Vorrichtung umfasst ferner eine Verpackungseinrichtung mit einer Falt- und Führungseinrichtung, wobei die Falt- und Führungseinrichtung einen Verpackungsmaterial-Aufnahmebereich mit einer Durchgangsöffnung aufweist und derart ausgebildet ist, dass die längliche Verpackungsmaterialbahn der Durchgangsöffnung zugeführt wird, welche wiederrum derart ausgeführt ist, dass die längliche Verpackungsmaterialbahn in Laufrichtung zu einer von der Durchgangsöffnung definierten schlauchförmigen Verpackungsmaterialbahn mit einem Verpackungsmaterial-Überlappungsbereich geformt wird, sowie eine oberhalb der Falt- und Führungseinrichtung angeordnete Leiteinrichtung mit einem Aufnahmeabschnitt für Arzneimittelportionen und einem Führungsabschnitt, der sich in Richtung der Durchgangsöffnung der Falt- und Führungseinrichtung erstreckt und Arzneimittelportionen in die schlauchförmige Verpackungsmaterialbahn leitet.The device according to the invention further comprises a packaging device with a folding and guiding device, wherein the folding and guiding device has a packaging material receiving area with a through opening and is designed such that the elongated packaging material web is fed to the through opening, which in turn is designed such that the elongated packaging material web is formed in the running direction to a defined by the passage opening tubular packaging material web with a packaging material overlap region, and arranged above the folding and guide device guide with a receiving portion for drug portions and a guide portion extending in the direction of the passage opening of the folding and guiding device extends and drug delivery leads into the tubular packaging material web.

Um die durch die Falt- und Führungseinrichtung schlauchförmig vorgeformte Verpackungsmaterialbahn zu geschlossenen Blisterbeuteln zu formen, ist bei der erfindungsgemäßen Vorrichtung eine stromab der Falt- und Führungseinrichtung angeordnete erste Fügeeinrichtung vorgesehen, welche die schlauchförmige Verpackungsmaterialbahn beim Verpackungsmaterial-Überlappungsbereich in Laufrichtung des schlauchförmigen Verpackungsmaterials zusammenfügt, so dass ein umfänglich geschlossener Schlauch entsteht. Ferner ist eine stromab der ersten Fügeeinrichtung angeordnete zweite Fügeeinrichtung vorgesehen, welche die schlauchförmige Verpackungsmaterialbahn in vorgegebenen Abständen, bezogen auf die Laufrichtung, zusammenfügt, so dass nach oben offene beutelförmige Aufnahmeabschnitte entstehen. Die zweite Fügeeinrichtung ist regelmäßig so ausgebildet, dass die Zusammenfügung der Verpackungsmaterialbahn in etwa orthogonal bzw. quer zur Laufrichtung der Verpackungsmaterialbahn durchgeführt wird, wobei die genaue Ausrichtung der Fügestelle von der zu erzielenden Form der Blisterbeutel abhängig ist.In order to form the packaging material web tube preformed by the folding and guiding device to form closed blister bags, a first joining device arranged downstream of the folding and guiding device is provided in the device according to the invention, which joins the tubular packaging material web in the packaging material overlap region in the running direction of the tubular packaging material that a circumferentially closed hose is formed. Furthermore, a second joining device arranged downstream of the first joining device is provided, which connects the tubular one Packaging material web at predetermined intervals, based on the direction of travel, zusammenfügt, so that upwardly open bag-shaped receiving portions arise. The second joining device is regularly designed such that the assembly of the packaging material web is performed approximately orthogonally or transversely to the direction of travel of the packaging material web, wherein the exact alignment of the joint depends on the shape of the blister bag to be achieved.

Im Hinblick auf den Stand der Technik ergeben sich bei der Handhabung der Verpackungsmaterialbahn und der Übergabe der Arzneimittelportionen erfindungsgemäß zwei wesentliche Unterschiede.With regard to the prior art, the handling of the packaging material web and the transfer of the medicament portions according to the invention result in two significant differences.

Zum einen wird die Verpackungsmaterialbahn zu einem anders ausgebildeten Aufnahmebereich geformt, nämlich einem nach oben offenen beutelförmigen Aufnahmebereich, so dass die Gefahr eines Herausspringens von Arzneimittelportionen allein aufgrund der geringeren Anzahl offener Seiten vermindert ist.On the one hand, the packaging material web is formed into a differently shaped receiving region, namely an upwardly open bag-shaped receiving region, so that the risk of a jump-out of medicament portions is reduced solely due to the smaller number of open sides.

Zum anderen ist die Zuführungsrichtung der Arzneimittelportionen bei der Übergabe in den beutelförmigen Aufnahmebereich eine andere. Aufgrund der Ausgestaltung des vorgeformten teilgeschlossenen Blisterbeutels war es im Stand der Technik notwendig, die Verpackungsmaterialbahn schräg, beispielsweise in einem 45° Winkel zu führen, und die Arzneimittelportionen dann beispielsweise von schräg oben in den teilgeschlossenen Blisterbeutel zu übergeben. Bauartbedingt wich die Zuführungsrichtung der Arzneimittelportionen im Aufnahmebereich stets von der Laufrichtung der Verpackungsmaterialbahn ab. Erfindungsgemäß ist es aber möglich, die Arzneimittelportionen im Aufnahmebereich entsprechend der Laufrichtung der Verpackungsmaterialbahn zuzuführen, da vor der Ausbildung der einzelnen Blisterbeutel ein beutelförmiger Verpackungsmaterialbahnabschnitt vorliegt, welcher von oben mit zu verblisternden Arzneimittelportionen befüllt werden kann. Diese beiden Maßnahmen führen dazu, dass selbst bei hohen Verarbeitungsgeschwindigkeiten nur eine sehr geringe Fehlerquote bei der Verblisterung der Arzneimittelportionen auftritt.On the other hand, the direction of delivery of the medicament portions when transferring into the bag-shaped receiving area is different. Due to the configuration of the preformed partially closed blister bag, it was necessary in the prior art, the packaging material web obliquely, for example, to lead at a 45 ° angle, and then transfer the drug portions, for example, obliquely from above into the partially closed blister. Due to the design, the feeding direction of the medicament portions in the receiving area always deviated from the running direction of the packaging material web. According to the invention, however, it is possible to supply the medicament portions in the receiving area corresponding to the direction of travel of the packaging material web, since prior to the formation of the individual blister pouches there is a bag-shaped packaging material web section which can be filled from above with medicament portions to be flashed. These two measures mean that even at high processing speeds only a very small error rate in the blistering of the drug portions occurs.

Die zweite Fügeeinrichtung ist derart ausgeführt, dass diese für die hohen erwünschten Arbeitsgeschwindigkeiten geeignet ist. Um periodisch eine Fügestelle im Wesentlichen quer zur Laufrichtung herzustellen kann Verpackungsmaterialbahn beispielsweise getaktet angehalten werden; in der Stoppzeit kann dann mit geeigneten Fügemitteln die Verpackungsmaterialbahn zusammengefügt werden.The second joining device is designed such that it is suitable for the high desired operating speeds. To periodically produce a joint substantially transverse to the direction of packaging material web can be stopped, for example, clocked; in the stop time, the packaging material web can then be joined together with suitable joining agents.

Aufgrund der erwünschten hohen Verarbeitungsgeschwindigkeit ist es aber bevorzugt, dass die Verpackungsmaterialbahn nicht periodisch angehalten wird. Um dies zu realisieren kann die Fügeeinrichtung beispielsweise gegenüberliegende rotierende Schweißwalzen mit einem oder mehreren Schweißmitteln umfassen. In welchem Abstand dann die Fügestellen eingebracht werden, hängt von mehreren Faktoren ab, nämlich der Laufgeschwindigkeit der Verpackungsmaterialbahn, der Rotationsgeschwindigkeit der Schweißwalzen und der Anzahl der Schweißmittel pro Schweißwalze.Due to the desired high processing speed, however, it is preferred that the packaging material web is not stopped periodically. To realize this, the joining device may, for example, comprise opposing rotating welding rolls with one or more welding means. At which distance then the joints are introduced, depends on several factors, namely the speed of the packaging material web, the rotational speed of the welding rollers and the number of welding agents per welding roller.

Die Anzahl der pro Blisterbeutel zu verblisternden Arzneimittelportionen schwankt; um eine optimale Ausnutzung der Verpackungsmaterialbahn zu gewährleisten ist es wünschenswert, Blisterbeutel mit unterschiedlichen Längen herzustellen. Bei einer bevorzugten Ausführungsform ist es daher vorgesehen, dass die zweite Fügeeinrichtung eine Antriebseinrichtung umfasst, mit welcher die zweite Fügeeinrichtung in und gegen die Laufrichtung der schlauchförmigen Verpackungsmaterialbahn bewegbar ist.The number of drug portions to be blistered per blister pack varies; In order to ensure optimum utilization of the packaging material web, it is desirable to produce blister bags of different lengths. In a preferred embodiment, it is therefore provided that the second joining device comprises a drive device with which the second joining device is movable in and against the running direction of the tubular packaging material web.

Bei dieser Ausführungsform wird die zweite Fügeeinrichtung bei dem Vorgang des Zusammenfügens der Verpackungsmaterialbahn mit dieser (quer zur Laufrichtung) mitgeführt und nach dem Zusammenfügen wieder gegen die Laufrichtung verfahren. Sobald alle einzubringenden Arzneimittelportionen dem beutelförmigen Aufnahmeabschnitt zugeführt sind, beginnt der Vorgang des Zusammenfügens erneut; die Länge der Blisterbeutel kann also ohne Änderung der Laufgeschwindigkeit der Verpackungsmaterialbahn dadurch variiert werden, dass die Zeitdauert zwischen den einzelnen Fügevorgängen variiert wird.In this embodiment, in the process of assembling the packaging material web, the second joining device is carried along with it (transversely to the running direction) and, after assembly, is again moved counter to the running direction. Once all the drug portions to be introduced are supplied to the bag-shaped receiving portion, the process of assembly begins again; The length of the blister bag can thus be varied without changing the running speed of the packaging material web, that the time between the individual joining operations is varied.

Bei der Verblisterung mit den bekannten Blisterautomaten entstehen üblicherweise Blisterschläuche mit einer Vielzahl von Blisterbeuteln, die jeweils eine Zusammenstellung von Arzneimittelportionen enthalten. Die Blisterschläuche werden üblicherweise außerhalb des Blisterautomaten in Rollenform gelagert. Die Blisterbeutel eines Blisterschlauches unterscheiden sich optisch quasi nicht, so dass eine Trennung nach Herausführen aus dem Blisterautomaten aufwendig ist.In the blistering with the known blister machines usually blister tubes with a variety of Blister bags, each containing a collection of drug portions. The blister tubes are usually stored outside the blister machine in roll form. The blister packs of a blister hose do not virtually differ visually, so that a separation after removal from the blister machine is complicated.

Bei einer bevorzugten Ausführungsform ist es daher vorgesehen, dass die Vorrichtung zum Verpacken von Arzneimittelportionen eine Schneideeinrichtung mit einem Schneidemittel umfasst, mit welcher der Blisterschlauch in vorgegebenen Abständen, bezogen auf die Laufrichtung, durchtrennt werden kann. Wie genau die Trennung durchgeführt wird, hängt von der genauen Ausgestaltung des Blisterschlauches ab. Üblicherweise ist eine quere Fügestelle Teil von zwei Blisterbeuteln, also das "untere" Ende eines und das "obere" Ende eines anderen Blisterschlauches. Eine Trennung erfolgt dann genau bei einer Fügestelle; umfasst jeder Blisterbeutel zwei "eigene" Fügestellen, kann zwischen zwei Fügestellen getrennt werden.In a preferred embodiment, it is therefore provided that the device for packaging medicament portions comprises a cutting device with a cutting means, with which the blister tube at predetermined intervals, based on the direction of travel, can be severed. How exactly the separation is carried out depends on the exact design of the blister hose. Usually, a transverse joint is part of two blister bags, ie the "lower" end of one and the "upper" end of another blister hose. A separation then takes place exactly at a joint; If each blister bag has two "own" joints, it can be separated between two joints.

Bei dieser Ausführungsform kann der Blisterschlauch bereits bei der Fertigung durchtrennt werden, ein nachträgliches Auffinden der Trennungsstelle entfällt. Mit einer entsprechenden Vorrichtung können auch Blisterschläuche ganz unterschiedlicher Länge problemlos hergestellt werden. Es ist sogar denkbar, die Blisterbeutel direkt nach der Herstellung zu vereinzeln.In this embodiment, the blister hose can already be severed during manufacture, a subsequent finding of the separation point is eliminated. Blister hoses of very different lengths can also be produced without problems with a corresponding device. It is even conceivable to separate the blister bags directly after production.

Auch bereits vorgetrennte Blisterschläuche umfassen mehrere Blisterbeutel, und diese Blisterbeutel betreffen regelmäßig mehrere Rezepte, Patienten bzw. Einnahmezeiten. Eine nachträgliche Trennung der Blisterbeutel wird also regelmäßig notwendig sein. Bei einer bevorzugten Ausführungsform der Vorrichtung zum Verpacken von Arzneimittelportionen umfasst das Schneidemittel eine Vielzahl von Schneidezähnen und der Blisterschlauch und das Schneidemittel sind derart relativ zueinander bewegbar angeordnet, dass der Blisterschlauch durchtrennbar oder perforierbar ist. Bei der erfindungsgemäßen Ausführungsform kann der Blisterschlauch also mit einem Bauteil sowohl durchtrennt als auch perforiert werden. So können beispielsweise patientenindividuelle Blisterschläuche hergestellt werden, deren einzelne Blisterbeutel aufgrund der zwischen diesen eingebrachten Perforation einfach voneinander gelöst und geöffnet werden können. Die Art und Weise der Verteilung Trennung/Perforierung kann je nach Anwendungsfall variiert werden.Also pre-separated Blister hoses include several blister packs, and these blister packs regularly affect several recipes, patients or intake times. Subsequent separation of the blister bag will therefore be necessary on a regular basis. In a preferred embodiment of the device for packaging medicament portions, the cutting means comprises a plurality of incisors, and the blister tube and the cutting means are arranged to be movable relative to one another such that the blister tube is severable or pierceable. In the embodiment according to the invention, the blister hose can therefore be provided with a component both severed and perforated. Thus, for example, patient-specific blister tubes can be produced, the individual blister bags can be easily solved and opened from each other due to the introduced between these perforation. The way of distribution separation / perforation can be varied depending on the application.

Bei einer weiteren bevorzugten Ausführungsform ist die Schneideeinrichtung baulich der zweiten Fügeeinrichtung zugeordnet, so dass das Trennen bzw. Perforieren besonders einfach durchgeführt werden kann, da ein genaues Erfassen der zu trennenden bzw. perforierenden Stelle nicht notwendig ist, da das Schneidemittel mit der Fügeeinrichtung mitgeführt wird.In a further preferred embodiment, the cutting device is structurally associated with the second joining device, so that the separation or perforation can be carried out particularly simply, since an exact detection of the point to be separated or perforated is not necessary, since the cutting means is carried along with the joining device ,

Bei einer besonders bevorzugten Ausführungsform umfasst die zweite Fügeeinrichtung ein Fügemittel, in welchem das Schneidemittel aufgenommen ist, und zwar derart, dass sich das Fügemittel in Laufrichtung der Verpackungsmaterialbahn stromab und stromauf des Schneidemittels erstreckt. Diese Ausführungsform macht das Perforieren und Durchtrennen besonders einfach und genau, da die Trennung/Perforierung stets bei einer gerade hergestellten Fügestelle stattfindet.In a particularly preferred embodiment, the second joining device comprises a joining means, in which the cutting means is accommodated, in such a way that the joining means extends in the running direction of the packaging material web downstream and upstream of the cutting means. This embodiment makes the perforating and cutting particularly simple and accurate, since the separation / perforation always takes place at a joint just made.

Die Erfindung betrifft ferner eine Verwendung einer Verpackungseinrichtung mit einer Falt- und Führungseinrichtung, wobei diese einen Verpackungsmaterial-Aufnahmebereich mit einer Durchgangsöffnung aufweist und derart ausgebildet ist, dass eine längliche Verpackungsmaterialbahn der Durchgangsöffnung zugeführt wird, welche derart ausgeführt ist, dass die längliche Verpackungsmaterialbahn in Laufrichtung zu einer von der Durchgangsöffnung definierten schlauchförmigen Verpackungsmaterialbahn mit einem Verpackungsmaterial-Überlappungsbereich geformt wird, einer oberhalb der Falt- und Führungseinrichtung angeordneten Leiteinrichtung mit einem Aufnahmeabschnitt für Arzneimittelportionen und einem Führungsabschnitt, der sich in Richtung der Durchgangsöffnung der Falt- und Führungseinrichtung erstreckt und Arzneimittelportionen in die schlauchförmige Verpackungsmaterialbahn leitet, einer stromab der Falt- und Führungseinrichtung angeordneten ersten Fügeeinrichtung, welche die schlauchförmige Verpackungsmaterialbahn beim Verpackungsmaterial-Überlappungsbereich in Laufrichtung des schlauchförmigen Verpackungsmaterials zusammenfügt, sowie einer stromab der ersten Fügeeinrichtung angeordneten zweiten Fügeeinrichtung, welche die schlauchförmige Verpackungsmaterialbahn in vorgegebenen Abständen, bezogen auf die Laufrichtung, zusammenfügt, zum Herstellen eines Arzneimittelportionen umfassenden Blisterschlauches.The invention further relates to a use of a packaging device with a folding and guiding device, which has a packaging material receiving area with a through opening and is designed such that an elongated packaging material web is fed to the through opening, which is designed such that the elongated packaging material web in the running direction to a tubular packaging material web defined by the through-opening is formed with a packaging material overlap region, a guide arranged above the folding and guiding device with a portion for drug portions and a guide portion which extends in the direction of the passage opening of the folding and guiding device and drug portions in the tubular The packaging material web leads, a first joining device arranged downstream of the folding and guiding device, which assembles the tubular packaging material web in the packaging material overlap region in the running direction of the tubular packaging material, and a second joining device arranged downstream of the first joining device, which feeds the tubular packaging material web at predetermined intervals relative to the Running direction, zusammenfügt, for producing a drug portions containing blister tube.

Weitere bevorzugte Ausführungsformen betreffen die Verwendung einer Verpackungseinrichtung mit den unter Bezugnahme auf die Vorrichtung beschriebenen zusätzlichen Merkmalen.Further preferred embodiments relate to the use of a packaging device with the additional features described with reference to the device.

Schließlich betrifft die Erfindung eine Verwendung einer Falt- und Führungseinrichtung zum Formen einer sich in einer Laufrichtung bewegenden Verpackungsmaterialbahn zum Herstellen eines Arzneimittelportionen enthaltenden Blisterschlauches, wobei die Falt- und Führungseinrichtung einen Verpackungsmaterial-Aufnahmebereich mit einer Durchgangsöffnung aufweist und derart ausgebildet ist, dass eine längliche Verpackungsmaterialbahn der Durchgangsöffnung zugeführt wird, welche derart ausgeführt ist, dass die längliche Verpackungsmaterialbahn in Laufrichtung zu einer von der Durchgangsöffnung definierten schlauchförmigen Verpackungsmaterialbahn mit einem Verpackungsmaterial-Überlappungsbereich geformt wird.Finally, the invention relates to a use of a folding and guiding device for forming a moving in a direction of packaging material web for producing a drug portions containing Blisterschlauches, wherein the folding and guiding means comprises a packaging material receiving portion having a through hole and is formed such that an elongated packaging material web is supplied to the through hole, which is designed such that the elongated packaging material web is formed in the running direction to a defined by the passage opening tubular packaging material web with a packaging material overlap region.

Im Nachfolgenden wird eine bevorzugte Ausführungsform der erfindungsgemäßen Vorrichtung zum Verpacken von Arzneimittelportionen sowie die Verwendung einzelner Bauteile dieser Vorrichtung unter Bezugnahme auf die beigefügte Zeichnung beschrieben, in welcher:

  • Figur 1 eine schematische perspektivische Ansicht einer bevorzugten Ausführungsform der erfindungsgemäßen Vorrichtung zeigt;
  • Figur 2 eine schematische Teilansicht der Verpackungseinrichtung in Relation zu einem Abschnitt der Führungs- und Sammelanordnung zeigt;
  • Figuren 3a - 3d verschiedene Ansichten der Verpackungseinrichtung zeigen;
  • Figur 4 eine Detailansicht der Verpackungseinrichtung zeigt;
  • Figur 5 eine perspektivische Ansicht der ersten Fügeeinrichtung der Verpackungseinrichtung zeigt;
  • Figuren 6a - 6b verschiedene perspektivische Ansichten der zweiten Fügeeinrichtung der Verpackungseinrichtung zeigen;
  • Figur 7 eine weitere Detailansicht der Verpackungseinrichtung zeigt;
  • Figuren 8a - 8c weitere Detailansichten der Verpackungsvorrichtung zeigen, wobei zur besseren Veranschaulichung ein Teil der Bauteile der Verpackungseinrichtung fortgelassen ist;
  • Figuren 9a - 9c verschiedene Ansichten einer Kombination Falt- und Führungseinrichtung/Leiteinrichtung zeigen; und
  • Figuren 10a - 10c verschiedene Detailansichten der Fügemittel der zweiten Fügeeinrichtung zeigen.
In the following, a preferred embodiment of the device according to the invention for packaging medicament portions and the use of individual components of this device will be described with reference to the attached drawing, in which:
  • FIG. 1 a schematic perspective view of a preferred embodiment of the device according to the invention;
  • FIG. 2 a schematic partial view of the packaging device in relation to a portion of the guiding and collecting arrangement shows;
  • FIGS. 3a-3d show different views of the packaging device;
  • FIG. 4 shows a detailed view of the packaging device;
  • FIG. 5 shows a perspective view of the first joining device of the packaging device;
  • Figures 6a - 6b show different perspective views of the second joining device of the packaging device;
  • FIG. 7 shows a further detail view of the packaging device;
  • FIGS. 8a-8c show further detail views of the packaging device, wherein for better illustration, a part of the components of the packaging device is omitted;
  • FIGS. 9a-9c show different views of a combination folding and guiding device / guide; and
  • FIGS. 10a-10c show different detailed views of the joining means of the second joining device.

Figur 1 zeigt eine schematische perspektivische Ansicht einer Ausführungsform der erfindungsgemäßen Vorrichtung zum Verpacken von Arzneimittelportionen, wobei der besseren Übersicht halber eine Vielzahl von für die Erfindung als solche unwesentlichen Bauteilen, wie beispielsweise Verkleidungsbauteile, fortgelassen sind. Die Vorrichtung 1 umfasst ein zentrales Rahmengerüst mit einer Mehrzahl von vertikalen Streben 2 (von denen lediglich eine sichtbar ist), drei horizontalen Streben 3a, 3b, 3c und mehreren Standstreben 4. Die untere horizontale Strebe 3c erstreckt sich im Wesentlichen über die gesamte Länge der Vorrichtung, die oberen horizontalen Streben 3a, 3b erstrecken sich nur im "rechten" Teil der Vorrichtung. FIG. 1 shows a schematic perspective view of an embodiment of the device according to the invention for the packaging of medicament portions, for the sake of clarity, a plurality of for the invention as such unessential components, such as cladding components, are omitted. The apparatus 1 comprises a central frame comprising a plurality of vertical struts 2 (only one of which is visible), three horizontal struts 3a, 3b, 3c and a plurality of struts 4. The lower horizontal strut 3c extends substantially the entire length of the struts Device, the upper horizontal struts 3a, 3b extend only in the "right" part of the device.

An dem Rahmengerüst ist eine Führungs- und Sammelanordnung angeordnet, die bei der gezeigten Ausführungsform aus einer Vielzahl von einzelnen Bauteilen besteht. Die Führungs- und Sammelanordnung umfasst drei Achsen 24a, 24b, 24c, die in entsprechenden Bohrungen der horizontalen Streben 3a, 3b, 3c aufgenommen sind. Die Achsen 24a, 24b, 24c umfassen eine (24c), zwei (24b), oder drei (24a) Umlenkrollen 25, wobei zwischen den Umlenkrollen 25 Transportriemen 22a, 22b, 22c angeordnet sind. Die Transportriemen selber sind entsprechend der Anordnung der Achsen 24a, 24b, 24c an den unterschiedlichen horizontalen Streben unterschiedlich lang; die beiden oberen Transportriemen sind gleich lang und bilden eine Art Verbund, der untere Transportriemen ist entsprechend länger und erstreckt sich im Wesentlichen über die gesamte Länge der Vorrichtung.On the framework, a guiding and collecting arrangement is arranged, which consists in the embodiment shown of a plurality of individual components. The leadership and Collection arrangement comprises three axes 24a, 24b, 24c, which are received in corresponding holes of the horizontal struts 3a, 3b, 3c. The axles 24a, 24b, 24c comprise one (24c), two (24b), or three (24a) pulleys 25, wherein between the pulleys 25 transport belts 22a, 22b, 22c are arranged. The transport belts themselves are different in length according to the arrangement of the axes 24a, 24b, 24c on the different horizontal struts; the two upper conveyor belts are the same length and form a kind of composite, the lower conveyor belt is correspondingly longer and extends substantially over the entire length of the device.

Wie es in Figur 1 gut zu erkennen ist, weist die Führungs- und Sammelanordnung bei der gezeigten Ausführungsform zwei Hauptbestandteile auf, wobei sich der Transportriemen 22c in einen Bereich der Vorrichtung 1 erstreckt, in welchen sich die beiden Transportriemen 22a, 22b nicht erstrecken. Diese Zweiteilung ist darin begründet, dass an den Transportriemen 22a, 22b und dem Transportriemen 22c verschiedene Komponenten der Führungs- und Sammelanordnung angeordnet sind. An bzw. zwischen den Transportriemen 22a, 22b sind an Haltemitteln 23 längliche Führungseinrichtungen 20 angeordnet, während an dem unteren Transportriemen 22c an Haltemitteln 23 Sammeleinrichtungen 21 angeordnet sind, wobei von den Führungseinrichtungen und den Sammeleinrichtungen jeweils zum Zwecke der Veranschaulichung nur wenige dargestellt sind.As it is in FIG. 1 can be clearly seen, the guide and collecting arrangement in the embodiment shown on two major components, wherein the transport belt 22c extends into a region of the device 1, in which the two transport belts 22a, 22b do not extend. This division into two parts is based on the fact that different components of the guiding and collecting arrangement are arranged on the transport belts 22a, 22b and the transport belt 22c. At or between the conveyor belts 22a, 22b, elongated guide means 20 are arranged on holding means 23, while collecting means 21 are arranged on holding means 23 on the lower conveyor belt 22c, only a few of the guide means and the collecting means being shown for the purpose of illustration.

Die Vorrichtung 1 umfasst einen Antrieb 26, mit dem die Achse 24a angetrieben werden kann, wodurch über die Umlenkrollen die Transportriemen 22a, 22b, 22c bewegt werden. Da die Transportriemen 22a, 22b und der Transportriemen 22c über die gleiche Achse 24a angetrieben sind, bewegen sich diese mit der gleichen Geschwindigkeit in Drehrichtung. Bezogen auf die Führungseinrichtungen und die Sammeleinrichtungen bedeutet dies, dass diese in dem Bereich zwischen den Achsen 24a und 24b mit gleicher Geschwindigkeit und ausgerichtet aneinander in Drehrichtung bewegt werden können, so dass für diese Wegstrecke des Gleichlaufes Arzneimittelportionen von einer Führungseinrichtung in eine unter dieser geführte Sammeleinrichtung übergeben werden können.The device 1 comprises a drive 26 with which the axle 24a can be driven, whereby the transport belts 22a, 22b, 22c are moved via the deflection rollers. Since the transport belts 22a, 22b and the transport belt 22c are driven via the same axis 24a, they move at the same speed in the direction of rotation. With respect to the guide means and the collection means this means that they can be moved in the area between the axes 24a and 24b at the same speed and aligned with each other in the direction of rotation, so that for this path of the synchronous drug portions of a Guide device can be transferred to a guided under this collector.

Bei der Vorrichtung zum Verpacken von Arzneimittelportionen sind die verschiedenen Arzneimittelportionen in einer Mehrzahl von Vorrats- und Abgabestationen 10 angeordnet, von denen in Abbildung 1 lediglich eine Teilmatrix angedeutet ist. Diese Vorrats- und Abgabestationen 10 sind über (nicht gezeigte) Bauteile an der Vorrichtung befestigt. Die Vorrats- und Abgabestationen umfassen einen Vorratsteil, in welchem Arzneimittelportionen gelagert sind, und einen Abgabeteil, über welchen einzelne Arzneimittelportionen auf Anforderung über eine Abgabeöffnung in eine Aufnahmeöffnung einer Führungseinrichtung übergeben werden. Bei der gezeigten Ausführungsform sind fünf horizontale Reihen von Vorrats- und Abgabestationen angeordnet, so dass in diesem Fall die Führungseinrichtung fünf Aufnahmeöffnungen umfasst, über welche Arzneimittelportionen aufgenommen werden können.In the device for packaging drug portions, the various drug portions are arranged in a plurality of supply and dispensing stations 10, of which in illustration 1 only a partial matrix is indicated. These storage and dispensing stations 10 are attached to the device via components (not shown). The storage and dispensing stations comprise a storage part, in which medicament portions are stored, and a dispensing part, via which individual medicament portions are transferred on request via a dispensing opening into a receiving opening of a guide device. In the embodiment shown, five horizontal rows of storage and dispensing stations are arranged, so that in this case the guide device comprises five receiving openings, via which medicament portions can be received.

Im Betrieb werden die Führungseinrichtungen über die Transportriemen 22a, 22b an den Vorrats- und Abgabestationen 10 vorbeigeführt und bei diesem Vorbeiführen können Arzneimittelportionen von den Vorrats- und Abgabestationen an die Führungseinrichtung abgegeben werden, die die Arzneimittelportionen an eine unter der Führungseinrichtung angeordnete und sich im Gleichklang mit dieser bewegende Sammeleinrichtung übergibt. Aufgrund der Bauweise der erfindungsgemäßen Vorrichtung wird eine Führungseinrichtung damit an sämtlichen Vorrats- und Abgabestationen 10 der Vorrichtung vorbeigeführt, so dass jeder Sammeleinrichtung bei jedem Durchlauf jede in der Vorrichtung gespeicherte Arzneimittelart zugeführt werden kann.In operation, the guide means are passed over the transport belts 22a, 22b to the supply and dispensing stations 10, and during this passage medicament portions can be dispensed from the supply and dispensing stations to the guide means, which align the drug portions with one below the guide means and in unison with this moving collecting device passes. Due to the construction of the device according to the invention, a guide device is thus guided past all the supply and delivery stations 10 of the device, so that each collection device can be supplied with each type of drug stored in the device during each run.

Die erfindungsgemäße Vorrichtung zum Verpacken von Arzneimittelportionen umfasst auf der "linken" Seite, auf welche sich die Transportriemen 22a, 22b nicht erstrecken, unterhalb des Transportriemens 22c, und damit unterhalb der an dem Transportriemen 22c befestigten Sammeleinrichtungen 21, eine Verpackungseinrichtung 30 und eine Verpackungsmaterial-Zuführung 40. Über die Verpackungsmaterial-Zuführung 40 wird der Verpackungseinrichtung eine längliche Verpackungsmaterialbahn 41 zugeführt. Die Verpackungseinrichtung 30 formt aus der länglichen Verpackungsmaterialbahn einen Blisterschlauch 45 mit einer Mehrzahl von Blisterbeuteln 44, wobei bei dieser Umformung Arzneimittelportionen, die in den Sammeleinrichtungen 21 temporär gelagert sind, an die jeweils entstehenden Blisterbeutel übergeben werden. Die Formung der Blisterbeutel und die Übergabe der Arzneimittelportionen in die Blisterbeutel wird unter Bezugnahme auf nachfolgende Figuren beschrieben.The device for packaging medicament portions according to the invention comprises on the "left" side, on which the transport belts 22a, 22b do not extend, below the transport belt 22c, and thus below the collecting devices 21 fastened to the transport belt 22c, a packaging device 30 and a packaging material. feed 40. About the packaging material supply 40 of the packaging means an elongated packaging material web 41 is supplied. The packaging device 30 forms from the elongated packaging material web a blister tube 45 with a plurality of blister bags 44, wherein during this transformation medicament portions, which are temporarily stored in the collection devices 21, are transferred to the respective blister bags. The formation of the blister bag and the transfer of the drug portions in the blister bag will be described with reference to the following figures.

Bei der gezeigten Ausführungsform ist die Führungs- und Sammelanordnung sehr komplex aufgebaut, ermöglicht aber eine hohe Verblisterungsgeschwindigkeit und einen Zugriff auf eine große Anzahl von Arzneimittelarten. Es sind aber auch weitaus einfachere Führungs- und Sammelanordnungen denkbar. Die Führungs- und Sammelanordnung kann beispielsweise lediglich eine (ortsfeste) Sammeleinrichtung umfassen, der sämtliche Zusammenstellungen an Arzneimittelportionen zugeführt werden. Auch denkbar ist, dass lediglich eine Führungseinrichtung vorgesehen ist, die Arzneimittelportionen von sämtlichen Vorrats- und Abgabestationen aufnehmen kann.In the embodiment shown, the guiding and collecting arrangement is very complex, but allows a high blinding speed and access to a large number of types of drugs. But there are also much simpler management and collective arrangements conceivable. For example, the guiding and collecting arrangement may comprise only one (stationary) collecting device, to which all compositions of medicament portions are supplied. It is also conceivable that only a guide means is provided which can receive drug portions of all supply and dispensing stations.

Figur 2 zeigt eine schematische Teilansicht der Verpackungseinrichtung in Relation zu einem Abschnitt der Führungs- und Sammelanordnung. Insbesondere ist Figur 2 die Ausrichtung der Verpackungseinrichtung 30 im Hinblick auf einen Abschnitt der Führungs- und Sammelanordnung zu entnehmen, nämlich die Ausrichtung einer Leiteinrichtung 60 der Verpackungseinrichtung 30 unterhalb der Sammeleinrichtungen 21. Zur Übergabe von in einer Sammeleinrichtung 21 temporär zwischengelagerten Arzneimittelportionen wird eine Abgabeklappe 27 der entsprechend ausgerichteten Sammeleinrichtung geöffnet und die in der Sammeleinrichtung angeordneten Arzneimittelportionen fallen schwerkraftbedingt in die Leiteinrichtung 60, welche sie der eigentlichen Verblisterung zuführt. FIG. 2 shows a schematic partial view of the packaging device in relation to a portion of the guiding and collecting arrangement. In particular FIG. 2 the orientation of the packaging device 30 with respect to a portion of the guiding and collecting arrangement, namely the orientation of a guide 60 of the packaging device 30 below the collecting means 21. For dispensing of temporarily stored in a collecting device 21 drug portions a dispensing flap 27 of the corresponding aligned collecting device opened and arranged in the collection drug portions fall by gravity in the guide 60, which feeds the actual Verblisterung.

Figuren 3a - 3d zeigen verschiedene Ansichten der Verpackungseinrichtung. Diese umfasst als wesentliche Bauteile die Leiteinrichtung 60, welche Zusammenstellungen von Arzneimittelportionen von den (nicht dargestellten) Sammeleinrichtungen übernimmt. Dazu weist die Leiteinrichtung 60 einen Aufnahmeabschnitt 61 auf, der trichterförmig ausgebildet ist. Die Leiteinrichtung 60 umfasst ferner einen Führungsabschnitt, der Arzneimittelportionen in einen Aufnahmebereich der zu einem oben offenen Blisterschlauch vorgeformten Verpackungsmaterialbahn zuführt, wobei der vorgenannte Vorgang unter Bezugnahme auf nachfolgende Figuren beschrieben wird. FIGS. 3a-3d show different views of the packaging device. This comprises, as essential components, the guiding device 60, which takes over assemblies of medicament portions from the collecting devices (not shown). For this purpose, the guide 60 has a receiving portion 61 which is funnel-shaped. The guide device 60 further comprises a guide section, which feeds drug portions into a receiving area of the packaging material web preformed to an open-top blister tube, the aforementioned process being described with reference to the following figures.

Die Falt- und Führungseinrichtung 50, die insbesondere nachfolgend unter Bezugnahme auf die Figuren 5a - 5c beschrieben wird, läuft mittig konisch zu und umfasst eine zentrale Durchgangsöffnung 51, mittels welcher die zugeführte Verpackungsmaterialbahn schlauchförmig ausgebildet wird. Im Groben hat die Falt- und Führungseinrichtung eine kraterförmige Ausgestaltung, wobei die Verpackungsmaterialbahn über die äußeren Flanken der Mitte zugeführt wird.The folding and guiding device 50, which in particular below with reference to the FIGS. 5a-5c is described conically at the center and comprises a central passage opening 51, by means of which the supplied packaging material web is formed tubular. Roughly, the folding and guiding device has a crater-like configuration, wherein the packaging material web is fed via the outer flanks of the middle.

Die Verpackungseinrichtung umfasst zum Ausbilden des separate Blisterbeutel aufweisenden Blisterschlauches eine erste Fügeeinrichtung 70 sowie eine zweite Fügeeinrichtung 90, wobei die erste Fügeeinrichtung 70, bezogen auf die Laufrichtung der Verpackungsmaterialbahn, stromab der Leiteinrichtung 60 und die zweite Fügeeinrichtung 90 stromab der ersten Fügeeinrichtung angeordnet ist.The packaging device comprises a first joining device 70 and a second joining device 90 for forming the blister bag having the separate blister bag, the first joining device 70 being located downstream of the guide 60 and the second joining device 90 downstream of the first joining device, with respect to the running direction of the packaging material web.

Wie oben dargelegt, wird mit der Falt- und Führungseinrichtung 50 die Verpackungsmaterialbahn schlauchförmig vorgeformt, ist aber noch zum Umfang des Schlauches sowie nach unten und nach oben offen. Die erste, stromab der Leiteinrichtung angeordnete Fügeeinrichtung fügt die Verpackungsmaterialbahn parallel zur Laufrichtung zusammen, so dass ein geschlossener Schlauch entsteht, der in Figur 3a unterhalb der ersten Fügeeinrichtung mit Bezugszeichen 42 angedeutet ist.As stated above, with the folding and guiding device 50, the packaging material web is preformed tube-shaped, but is still open to the circumference of the tube and downwards and upwards. The first, arranged downstream of the guide joining device adds the packaging material web parallel to the direction, so that a closed tube is formed in FIG. 3a below the first joining device is indicated by reference numeral 42.

Unterhalb der ersten Fügeeinrichtung 70 ist die zweite Fügeeinrichtung 90 angeordnet, mittels welcher der geschlossene Schlauch quer zur Laufrichtung zusammengefügt wird, es wird mit dieser Fügeeinrichtung also die Beutelform als Solche erzeugt. Bei der gezeigten Ausführungsform ist die zweite Fügeeinrichtung 90 derart ausgebildet, dass diese mit und gegen die Laufrichtung der Verpackungsmaterialbahn bewegt werden kann. Zum Zusammenfügen bzw. Einbringen einer Fügestelle in die schlauchförmige Verpackungsmaterialbahn 42 werden die Fügemittel 91a, 91b zusammengefahren. Sobald die Fügemittel zusammengefahren sind, wird die Fügeeinrichtung in Laufrichtung nach unten bewegt, wobei die Dauer des Zusammenführens abhängig ist von der Zeitdauer, die zum sicheren Zusammenfügen notwendig ist. Bei der Fügestelle handelt es sich üblicherweise um eine Schweißnaht, es sind jedoch auch andere Arten des Zusammenfügens denkbar.Below the first joining device 70, the second joining device 90 is arranged, by means of which the closed tube is joined transversely to the direction of rotation, it is thus produced with this joining means the bag shape as such. In the embodiment shown, the second joining device 90 is designed such that it can be moved with and against the running direction of the packaging material web. For joining or introducing a joint into the tubular packaging material web 42, the joining means 91a, 91b are moved together. Once the joining means have moved together, the joining device is moved downwards in the running direction, the duration of the merging being dependent on the time required for secure joining. The joint is usually a weld, but other types of assembly are also conceivable.

Sobald die Fügestelle hergestellt ist, werden die Fügemittel auseinandergefahren und die Fügeeinrichtung als Solche wieder gegen die Laufrichtung "nach oben" verfahren. Sobald die "untere" Fügestelle eingebracht ist, können von oben Arzneimittelportionen über die Leiteinrichtung dem gerade geschaffenen Aufnahmebereich zugeführt werden. Dieser Aufnahmebereich ist nach Einbringen der Fügestelle als oben offener Beutel ausgebildet.Once the joint is made, the joining means are moved apart and moved the joining device as such again against the direction "up". As soon as the "lower" joint has been introduced, medicament portions can be supplied from above via the guide device to the receiving region just created. This receiving area is formed after insertion of the joint as open top bag.

Beim eigentlichen Einbringen der Arzneimittelportionen wird die Verpackungsmaterialbahn nicht angehalten, sondern wird weiter in Laufrichtung bewegt, so dass sich diese bei dem Befüllvorgang nach unten weiterbewegt. Die eigentliche Befüllung bzw. das Einbringen von Arzneimittelportionen in den Aufnahmeabschnitt, also den oben offenen vorgeformten Blisterbeutel, erfolgt aber getaktet.During the actual introduction of the medicament portions, the packaging material web is not stopped, but is moved further in the running direction, so that it continues to move downwards during the filling process. The actual filling or the introduction of drug portions in the receiving portion, so the open-top preformed blister, but clocked.

Sobald sämtliche Arzneimittelportionen eingebracht sind, werden die Fügemittel 91a, 91b der zweiten Fügeeinrichtung erneut zusammengefahren und diese mit der Verpackungsmaterialbahn nach unten bewegt, wobei eine weitere Fügestelle eingebracht wird, die gleichzeitig die "obere" Fügestelle des gerade hergestellten Blisterbeutels und die "untere" Fügestelle des nachfolgend herzustellenden Blisterbeutels ist.As soon as all the medicament portions have been introduced, the joining means 91a, 91b of the second joining device are again brought together and the latter moved downwards with the packaging material web, whereby a further joint is introduced, which simultaneously produces the "upper" Joint of the blister bag just made and the "bottom" joint of the subsequently produced Blisterbeutels is.

Der Verpackungseinrichtung ist eine Verpackungsmaterial-Zuführung 40 zugeordnet, über welche die längliche Verpackungsmaterialbahn 41 der Falt- und Führungseinrichtung 50 zugeführt wird (siehe insbesondere Figur 3d). Die Verpackungsmaterial-Zuführung 40 umfasst eine zentrale Verpackungsmaterialrolle 46 und diverse Umlenkrollen, die die längliche Verpackungsmaterialbahn 41 schließlich der Falt- und Führungseinrichtung 50 zuführen. Bei der in Figur 3d gezeigten Ausführungsform sind zwei der diversen Umlenkrollen mit einem Antrieb 47 gekoppelt. Bei der gezeigten Ausführungsform ist die Verpackungsmaterial-Zuführung 40 zentraler Bestandteil der Verpackungseinrichtung; bei anderen Ausführungsformen kann die Verpackungsmaterial-Zuführung außerhalb der eigentlichen Verpackungseinrichtung angeordnet sein, um einen raschen Wechsel der Verpackungsmaterialrolle zu gewährleisten.The packaging device is associated with a packaging material feed 40, via which the elongated packaging material web 41 of the folding and guiding device 50 is supplied (see in particular 3d figure ). The packaging material feed 40 comprises a central packaging material roll 46 and various deflection rollers, which finally supply the elongate packaging material web 41 to the folding and guiding device 50. At the in 3d figure shown embodiment, two of the various pulleys are coupled to a drive 47. In the embodiment shown, the packaging material supply 40 is a central component of the packaging device; in other embodiments, the packaging material supply may be disposed outside of the actual packaging device to ensure a rapid change of the packaging material roll.

Figur 4 zeigt eine Detailansicht der Verpackungseinrichtung. Figur 4 ist zu entnehmen, dass bei der gezeigten Ausführungsform der zweiten Fügeeinrichtung 90 eine Antriebseinheit 100 zugeordnet ist, mit welcher der die Fügemittel 91a, 91b umfassende Teil der zweiten Fügeeinrichtung in und gegen die Laufrichtung der Verpackungsmaterialbahn bewegt werden kann. Figur 4 ist zu entnehmen, dass die erste Fügeeinrichtung 70 zwei Antriebsriemen 74a, 74b umfasst, welche einen Verpackungsmaterial-Überlappungsbereich 43 umgreift, der aufgrund der speziellen Ausgestaltung der Falt- und Führungseinrichtung ausgebildet ist. Bei diesem Verpackungsmaterial-Überlappungsbereich 43 findet auch die eigentliche Zusammenfügung des Verpackungsmaterials parallel zur Laufrichtung des Verpackungsmaterials statt, wobei die dazu genutzten Bauteile unter Bezugnahme auf nachfolgende Figuren beschrieben werden. FIG. 4 shows a detailed view of the packaging device. FIG. 4 It can be seen that in the embodiment shown, the second joining device 90 is associated with a drive unit 100 with which the part of the second joining device comprising the joining means 91a, 91b can be moved in and against the running direction of the packaging material web. FIG. 4 It can be seen that the first joining device 70 comprises two drive belts 74a, 74b, which encompasses a packaging material overlapping region 43, which is formed on account of the special configuration of the folding and guiding device. In this packaging material overlap region 43, the actual assembly of the packaging material takes place parallel to the running direction of the packaging material, wherein the components used for this purpose are described with reference to the following figures.

In Figur 4 ist ferner eine dem Fügemittel 91b zugeordnete Horizontalverstellung 92 zu erkennen, mit welchem das Fügemittel in X-Richtung auf die schlauchförmige Verpackungsmaterialbahn zum Einbringen einer Fügestelle bewegt werden und nach Einbringen der Fügestelle entfernt werden kann. Mit der gerade angesprochenen Antriebseinheit 100 kann die zweite Fügeeinrichtung in Y-Richtung in und gegen die Laufrichtung der Verpackungsmaterialbahn bewegt werden.In FIG. 4 Furthermore, a horizontal adjustment 92 assigned to the joining means 91b can be seen, with which the joining means can be moved in the X direction on the tubular packaging material web for introducing a joint and can be removed after introduction of the joint. With the drive unit 100 just mentioned, the second joining device can be moved in the Y direction in and against the running direction of the packaging material web.

Figur 5 zeigt eine perspektivische Ansicht der ersten Fügeeinrichtung 70 der Verpackungseinrichtung. Die erste Fügeeinrichtung umfasst eine Aufnahmeplatte 71, auf welcher die Falt- und Fügeeinrichtung angeordnet ist. Zum Unterstützen der Bewegung der schlauchförmig vorgeformten Verpackungsmaterialbahn umfasst die erste Fügeeinrichtung zwei Antriebsriemen 74a, 74b, die den Verpackungsmaterial-Überlappungsbereich umgreifen. Von der Falt- und Führungseinrichtung wird die längliche Verpackungsmaterialbahn schlauchförmig vorgeformt und der schlauchförmige Verpackungsmaterial-Überlappungsbereich bereitgestellt. Die eigentliche Zusammenfügung in Laufrichtung findet bei diesem Verpackungsmaterial-Überlappungsbereich statt, und zwar indem dieser Überlappungsbereich verschweißt wird. Dazu umfasst die erste Fügeeinrichtung 70 Fügemittel 73a, 73b die zum Zusammenfügen des Verpackungsmaterials an diesem anliegen; zur besseren Veranschaulichung der einzelnen Bauteile sind die Fügemittel in Figur 5 beabstandet voneinander angezeigt. Die Fügemittel 73a, 73b und die Antriebsriemen 74a, 74b sind mit Antrieben 72a - 72c gekoppelt. FIG. 5 shows a perspective view of the first joining means 70 of the packaging device. The first joining device comprises a receiving plate 71 on which the folding and joining device is arranged. To assist in the movement of the tubular preformed packaging material web, the first joining means comprises two drive belts 74a, 74b which engage around the packaging material overlap region. From the folding and guiding device, the elongated packaging material web is preformed tubular and provided the tubular packaging material overlap region. The actual assembly in the direction takes place in this packaging material overlap area, namely by this overlap area is welded. For this purpose, the first joining device 70 comprises joining means 73a, 73b which rest against the packaging material for joining the latter; to better illustrate the individual components, the joining means in FIG. 5 spaced apart from each other. The joining means 73a, 73b and the drive belts 74a, 74b are coupled to drives 72a-72c.

Figuren 6a - 6b zeigen zwei perspektivische Ansichten der zweiten Fügeeinrichtung 90. Zum Einbringen einer Fügestelle in die Verpackungsmaterialbahn umfasst die zweite Fügeeinrichtung 90 zwei Fügemittel 91a, 91b, die horizontal verfahren werden können. Dazu umfasst die zweite Fügeeinrichtung zwei Horizontalverstellungen 92, 93, die getrennt voneinander bewegt werden können. Wie bereits unter Bezugnahme auf vorgenannte Figuren beschrieben, ist der in den Figuren 6a, 6b gezeigte Abschnitt der zweiten Fügeeinrichtung über eine Antriebseinheit 100 in und gegen die Laufrichtung der Verpackungsmaterialbahn bewegbar. Figures 6a - 6b show two perspective views of the second joining device 90. For introducing a joint in the packaging material web, the second joining means 90 comprises two joining means 91a, 91b, which can be moved horizontally. For this purpose, the second joining device comprises two horizontal displacements 92, 93, which can be moved separately from one another. As already described with reference to the aforementioned figures, in the FIGS. 6a, 6b shown portion of the second joining device via a drive unit 100 in and against the direction of travel of the packaging material web movable.

Figur 7 zeigt eine Detailansicht der Verpackungseinrichtung, und zwar in dem Bereich des Einbringens der Arzneimittelportionen und das Zusammenfügens der Verpackungsmaterialbahn. FIG. 7 shows a detailed view of the packaging device, in the area of the introduction of the drug portions and the joining of the packaging material web.

Figur 7 ist insbesondere der Lauf der Verpackungsmaterialbahn durch die erste und zweite Fügeeinrichtung zu entnehmen. Die Falt- und Führungseinrichtung 50 formt die Verpackungsmaterialbahn zu einer schlauchförmigen Verpackungsmaterialbahn 42 mit einem Verpackungsmaterial-Überlappungsbereich 43, der stromab der Falt- und Führungseinrichtung mittels der Fügemittel 73a, 73b zusammengefügt wird, wobei bei der dargestellten Ausführungsform ein Verschweißen des Überlappungsbereiches stattfindet. Bei der stromab der ersten Fügeeinrichtung 70 angeordneten zweiten Fügeeinrichtung 90 findet das Einbringen der horizontalen Fügestellen statt, wobei bei der gezeigten Ausführungsform auch hier eine Schweißnaht eingebracht wird. Im Detail umfasst das Fügemittel 91a dazu zwei Schweißkanten 94a, 94b, die bei der eigentlichen Einbringung der Verschweißung die zu verschweißende Verpackungsmaterialbahn gegen zwei Gegenkanten 95a, 95b des Fügemittels 91a drücken. Bei der gezeigten Ausführungsform umfasst das Fügemittel 91a ein Schneidemittel 111, welches mittig in das Fügemittel eingelassen ist, und zwar derart, dass die Schweißkanten 94a, 94b bezüglich der Laufrichtung der Verpackungsmaterialbahn stromab und stromauf zu dem Schneidemittel angeordnet sind. FIG. 7 In particular, the course of the packaging material web can be seen through the first and second joining device. The folding and guiding device 50 forms the packaging material web into a tubular packaging material web 42 having a packaging material overlap region 43 which is joined downstream of the folding and guiding device by means of the joining means 73a, 73b, wherein welding of the overlapping region occurs in the illustrated embodiment. In the case of the second joining device 90 arranged downstream of the first joining device 70, the introduction of the horizontal joints takes place, with a weld also being introduced here in the embodiment shown. In detail, the joining means 91a for this purpose comprises two welding edges 94a, 94b which press the packaging material web to be welded during the actual introduction of the welding against two opposing edges 95a, 95b of the joining means 91a. In the embodiment shown, the joining means 91a comprises a cutting means 111, which is embedded centrally in the joining means, such that the welding edges 94a, 94b are arranged downstream and upstream of the cutting means with respect to the running direction of the packaging material web.

Figuren 8a - 8c zeigen weitere Detailansichten der Verpackungseinrichtung, wobei zur besseren Veranschaulichung ein Teil der Bauteile der Verpackungseinrichtung fortgelassen ist. Bei Figur 8a ist der Verlauf der Verpackungsmaterialbahn mit dem Überlappungsbereich 43 gut zu erkennen. Die zweite Fügeeinrichtung 90 ist in der offenen Stellung dargestellt, und unterhalb der zweiten Fügeeinrichtung 90 ist der Blisterschlauch 45 als solches angedeutet; die genaue Führung des Blisterschlauches nach dem Herstellen der einzelnen Blisterbeutel ist nicht weiter dargestellt. FIGS. 8a-8c show further detail views of the packaging device, wherein a part of the components of the packaging device is omitted for better illustration. at FIG. 8a the course of the packaging material web with the overlap region 43 can be clearly seen. The second joining device 90 is shown in the open position, and below the second joining device 90, the blister hose 45 is indicated as such; the exact guidance of the blister after making the individual blister bag is not shown.

Bei Figur 8b ist das Verpackungsmaterial als solches fortgelassen, und es ist der Führungsabschnitt 62 der Leiteinrichtung 60 zu erkennen, der sich durch die zentrale Durchgangsöffnung 51 der Falt- und Führungseinrichtung 50, die in Figur 8c veranschaulicht ist, erstreckt. Der Führungsabschnitt 62 unterstützt die Ausbildung und Formung der schlauchförmigen Verpackungsmaterialbahn und führt die Arzneimittelportionen dem eigentlichen Aufnahmebereich der vorgeformten Verpackungsmaterialbahn zu, welcher sich unterhalb des Führungsabschnittes 62 befindet. Wie genau die Arzneimittelportionen in die vorgeformte Verpackungsmaterialbahn eingebracht werden, wurde bereits unter Bezugnahme auf vorhergehende Figuren beschrieben.at FIG. 8b is omitted as the packaging material, and it is the guide portion 62 of the guide 60 can be seen, extending through the central through hole 51 of the folding and guiding device 50, which in FIG. 8c is illustrated extends. The guide section 62 assists in the formation and shaping of the tubular packaging material web and delivers the medicament portions to the actual receiving region of the preformed packaging material web, which is located below the guide section 62. How exactly the medicament portions are introduced into the preformed packaging material web has already been described with reference to the preceding figures.

Figuren 9a - 9c zeigen verschiedene Ansichten der Kombination Falt- und Führungseinrichtung/Leiteinrichtung. Figur 9a zeigt die vorgenannte Kombination wie sie in der Verpackungseinrichtung verbaut ist. Der Führungsabschnitt 62 der Leiteinrichtung 60 erstreckt sich durch eine zentrale Durchgangsöffnung 51 der Falt- und Führungseinrichtung 50. Bei Figur 9b ist die Leiteinrichtung 60 vertikal in Bezug auf die Falt- und Führungseinrichtung 50 verschoben, bei Figur 9c sind die beiden vorgenannten Bauteile separat voneinander dargestellt. Die Formgebung der Verpackungsmaterialbahn findet statt, indem diese die Flanken der Falt- und Führungseinrichtung hin zu der zentralen Durchgangsöffnung hochläuft und sich nach unten in diese erstreckt. Bei der gezeigten Ausführungsform ist die zentrale Durchgangsöffnung 51 der Falt- und Führungseinrichtung 50 nach außen nicht geschlossen, sondern weißt einen Spalt 53 auf, wobei dieser Spalt bei der Formung der Verpackungsmaterialbahn den Verpackungsmaterial-Überlappungsbereich 43 ausbildet. Ein entsprechender Überlappungsbereich könnte auch durch andere Ausgestaltungen der zentralen Durchgangsöffnung bzw. der Falt- und Führungseinrichtung bereitgestellt werden. FIGS. 9a-9c show different views of the combination folding and guide device / guide. FIG. 9a shows the aforementioned combination as it is installed in the packaging device. The guide portion 62 of the guide 60 extends through a central through hole 51 of the folding and guiding device 50. Bei FIG. 9b the guide 60 is displaced vertically with respect to the folding and guiding device 50 at FIG. 9c the two aforementioned components are shown separately from each other. The shaping of the packaging material web takes place in that it runs up the flanks of the folding and guiding device towards the central passage opening and extends downwards into the latter. In the embodiment shown, the central through-opening 51 of the folding and guiding device 50 is not closed to the outside, but has a gap 53, this gap forming the packaging material overlapping area 43 during the formation of the packaging material web. A corresponding overlapping region could also be provided by other embodiments of the central through-opening or the folding and guiding device.

Figuren 10 - 10c zeigen Detailansichten des Bereiches der Fügemittel der zweiten Fügeeinrichtung 90. Figur 10a zeigt eine Momentaufnahme des Einbringens einer Fügestelle quer zur Laufrichtung der Verpackungsmaterialbahn. Das Fügemittel 91a umfasst eine horizontale Ausnehmung, in der ein Schneidemittel 111 angeordnet ist. Stromab und stromauf des Schneidemittels umfasst das Fügemittel 91a Schweißkanten 94a, 94b, die mit Gegenkanten 95a, 95b des Fügemittels 91b zusammenwirken. Figur 10b veranschaulicht die Schneideeinrichtung 110, umfassend ein Schneidemittel 111 mit einer Mehrzahl von Schneidezähnen 112. Das Schneidemittel 111 als solches ist über mehrere Bauteile direkt mit der Horizontalverstellung 93 verbunden. Das Fügemittel 91a ist über Federn 96a, 96b mit der vorgenannten Horizontalverstellung verbunden. Ein Bewegen der Horizontalverstellung bewegt also sowohl das Fügemittel als auch das Schneidemittel. Sobald aber das Fügemittel 91a über seine Schweißkanten an einen Anschlag bewegt wird, der regelmäßig über die Gegenkanten 95a, 95b bereitgestellt ist, findet eine Relativbewegung des Schneidemittels 111 zu dem Fügemittel 91a statt, und zwar indem das Fügemittel 91a über das Fügemittel 91b, welches mit einer Horizontalverstellung 93 gekoppelt ist, in die Federn 96a, 96b gedrückt wird (siehe dazu Figur 10c). Figures 10 - 10c show detailed views of the region of the joining means of the second joining device 90. FIG. 10a shows one Snapshot of the introduction of a joint transverse to the direction of the packaging material web. The joining means 91a comprises a horizontal recess in which a cutting means 111 is arranged. Downstream and upstream of the cutting means, the joining means 91a comprises welding edges 94a, 94b which cooperate with counter edges 95a, 95b of the joining means 91b. FIG. 10b 1 illustrates the cutting device 110, comprising a cutting means 111 having a plurality of cutting teeth 112. The cutting means 111 as such is directly connected to the horizontal adjustment 93 via a plurality of components. The joining means 91a is connected via springs 96a, 96b with the aforementioned horizontal adjustment. Moving the horizontal adjustment thus moves both the joining means and the cutting means. However, as soon as the joining means 91a is moved over its welding edges to a stop which is regularly provided over the opposite edges 95a, 95b, a relative movement of the cutting means 111 to the joining means 91a takes place, by the joining means 91a via the joining means 91b, which with a horizontal adjustment 93 is coupled, is pressed in the springs 96a, 96b (see FIG. 10c ).

Bei der Relativbewegung des Schneidemittels 111 zu dem Fügemittel 91b tritt das Schneidemittel aus der Aufnahme innerhalb des Fügemittels 91a heraus und dringt in die zwischen den Fügemitteln angeordnete Verpackungsmaterialbahn ein. In Abhängigkeit von dieser Relativbewegung kann die Verpackungsmaterialbahn mittels der Schneidezähne perforiert oder durchtrennt werden. Bei einer lediglich geringen Relativbewegung findet die Perforation statt, wird das Fügemittel 91a über das Fügemittel 91b weiter in die Federn 96a, 96b gedrückt, findet ein Durchtrennen der Verpackungsmaterialbahn statt.During the relative movement of the cutting means 111 to the joining means 91b, the cutting means emerges from the receptacle within the joining means 91a and penetrates into the packaging material web arranged between the joining means. Depending on this relative movement, the packaging material web can be perforated or severed by means of the incisors. If there is only a slight relative movement, the perforation takes place; if the joining means 91a is pushed further into the springs 96a, 96b via the joining means 91b, the packaging material web is severed.

Claims (12)

  1. A device (1) for packaging drug portions, having
    a plurality of reservoir and dispensing stations (10) for dispensing individual drug portions,
    at least one conveyance and collecting apparatus for receiving the drug portions dispensed by the reservoir and dispensing stations (10) and transferring the drug portions,
    a packaging material feed (40) for feeding a flexible, elongated packaging material web (41),
    a packaging device (30) with a folding and conveyance device (50), wherein the folding and conveyance device (50) has a packaging material receiving area (52) with a passage (51), and is designed in such a manner that the elongated packaging material web (41) is fed to the passage (51), which is designed in such a manner that the elongated packaging material web (41) is molded in the direction of movement into a tubular packaging material web (42), the shape of which is defined by the passage (51), having a packaging material overlap region (43),
    a first joining device (70) arranged downstream of the folding and conveyance device (50), which joins the tubular packaging material web (42) at the packaging material overlap region (43) in the direction of movement of the tubular packaging material (42), and
    a second joining device (90) arranged downstream of the first joining device (70), which joins the tubular packaging material web (42) at prespecified intervals with respect to the direction of movement, such that a continuous blister tube (45) is created,
    characterized by a guide device (60) arranged above the folding and conveyance device (50), having a receiving segment (61) for drug portions and a conveying segment (62) which extends in the direction of the passage (51) of the folding and conveyance device (50) and which guides drug portions into the tubular packaging material web (42).
  2. The device (1) for packaging drug portions according to claim 1,
    characterized in that
    the second joining device (90) has a drive device (100) by means of which the second joining device (90) can be moved in and opposite to the direction of movement of the tubular packaging material web (42).
  3. The device (1) for packaging drug portions according to claim 1 or 2,
    characterized in that
    the device (1) for packaging drug portions has a cutting device (110) with a cutting means (111) by means of which the blister tube (45) can be severed at prespecified intervals with respect to the direction of movement.
  4. The device (1) for packaging drug portions according to claim 3,
    characterized in that
    the cutting means (111) comprises a plurality of cutting teeth (112), and in that the blister tube (42) and the cutting means (111) are arranged to be able to move relative to each other in such a manner that the blister tube (42) can be severed or perforated.
  5. The device (1) for packaging drug portions according to one of the claims 3 or 4,
    characterized in that
    the cutting device (110) is functionally assigned to the second joining device (90).
  6. The device (1) for packaging drug portions according to one of the claims 3 to 5,
    characterized in that
    the second joining device (90) has a joining means (91a) in which the cutting means (111) is accommodated.
  7. The use of a packaging device (30), having
    a folding and conveyance device (50), wherein the folding and conveyance device (50) has a packaging material receiving area (52) with a passage (51), and is designed in such a manner that the elongated packaging material web (41) is fed to the passage (51), which is designed in such a manner that the elongated packaging material web (41) is molded in the direction of movement into a tubular packaging material web (42), the shape of which is defined by the passage (51), having a packaging material overlap region (43),
    a first joining device (70) arranged downstream of the folding and conveyance device (50), which joins the tubular packaging material web (42) at the packaging material overlap region (43) in the direction of movement of the tubular packaging material (42), and
    a second joining device (90) arranged downstream of the first joining device (70), which joins the tubular packaging material web (42) at prespecified intervals with respect to the direction of movement,
    for the purpose of producing a blister tube (45) which contains drug portions,
    characterized by a guide device (60) arranged above the folding and conveyance device (50), having a receiving segment (61) for drug portions and a conveying segment (62) which extends in the direction of the passage (51) of the folding and conveyance device (50) and which guides drug portions into the tubular packaging material web (42).
  8. The use of a packaging device (30) for the production of a blister tube (45) which contains drug portions, according to claim 7,
    characterized in that
    the second joining device (90) has a drive device (100) by means of which the second joining device (90) can be moved in and opposite to the direction of movement of the tubular packaging material web (42).
  9. The use of a packaging device (30) for the production of a blister tube (45) which contains drug portions, according to claim 7 or 8,
    characterized in that
    the device (1) for packaging drug portions has a cutting device (110) with a cutting means (111) by means of which the blister tube can be severed at prespecified intervals with respect to the direction of movement.
  10. The use of a packaging device (30) for the production of a blister tube (45) which contains drug portions, according to claim 9,
    characterized in that
    the cutting means (111) comprises a plurality of cutting teeth (112), and can be moved in such a manner that the blister tube can be severed or perforated.
  11. The use of a packaging device (30) for the production of a blister tube (45) which contains drug portions, according to claim 9 or 10,
    characterized in that
    the cutting device (110) is functionally assigned to the second joining device (90).
  12. The use of a packaging device (30) for the production of a blister tube (45) which contains drug portions, according to one of the claims 9 to 11,
    characterized in that the second joining device (90) has a joining means (91a) in which the cutting means (111) is accommodated.
EP17165405.6A 2017-04-07 2017-04-07 Device for packaging drug portions Active EP3385174B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK17165405T DK3385174T3 (en) 2017-04-07 2017-04-07 DEVICE FOR PACKAGING OF PHARMACEUTICAL PORTIONS
EP17165405.6A EP3385174B1 (en) 2017-04-07 2017-04-07 Device for packaging drug portions
CA3056480A CA3056480A1 (en) 2017-04-07 2018-03-13 Device for packaging pharmaceutical portions
JP2019554983A JP2020516546A (en) 2017-04-07 2018-03-13 Device for packaging drug potions
CN201880023514.5A CN110536838A (en) 2017-04-07 2018-03-13 Facility for being packed to drug part
PCT/EP2018/056274 WO2018184795A1 (en) 2017-04-07 2018-03-13 Device for packaging pharmaceutical portions
KR1020197029406A KR102532860B1 (en) 2017-04-07 2018-03-13 device for pharmaceutical packaging
BR112019020156-4A BR112019020156B1 (en) 2017-04-07 2018-03-13 DEVICE FOR PACKAGING PORTIONS OF DRUGS, USE OF A PACKAGING DEVICE AND USE OF A FOLDING AND TRANSPORTING DEVICE
AU2018249339A AU2018249339B2 (en) 2017-04-07 2018-03-13 Device for packaging pharmaceutical portions
JP2022189400A JP7497412B2 (en) 2017-04-07 2022-11-28 Device for packaging pharmaceutical portions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17165405.6A EP3385174B1 (en) 2017-04-07 2017-04-07 Device for packaging drug portions

Publications (2)

Publication Number Publication Date
EP3385174A1 EP3385174A1 (en) 2018-10-10
EP3385174B1 true EP3385174B1 (en) 2019-09-18

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EP17165405.6A Active EP3385174B1 (en) 2017-04-07 2017-04-07 Device for packaging drug portions

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KR (1) KR102532860B1 (en)
CN (1) CN110536838A (en)
AU (1) AU2018249339B2 (en)
BR (1) BR112019020156B1 (en)
CA (1) CA3056480A1 (en)
DK (1) DK3385174T3 (en)
WO (1) WO2018184795A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3912918A1 (en) 2020-05-20 2021-11-24 Becton Dickinson Rowa Germany GmbH Packaging device for small items and method for producing a blister tube comprising a plurality of blister bags
US11208223B2 (en) 2020-05-20 2021-12-28 Becton Dickinson Rowa Germany Gmbh Packaging apparatus for small piece goods and method for producing a blister tube comprising a plurality of blister bags
EP3995401A1 (en) 2020-11-09 2022-05-11 Becton Dickinson Rowa Germany GmbH Method and device for producing a blister tube, and blister tube
US11273103B1 (en) 2021-06-22 2022-03-15 Vmi Holland B.V. Method, computer program product and dispensing device for dispensing discrete medicaments
US11498761B1 (en) 2021-06-22 2022-11-15 Vmi Holland B.V. Method for dispensing discrete medicaments, a test station for testing a feeder unit, and a method for determining a fill level of a feeder unit
US11673700B2 (en) 2021-06-22 2023-06-13 Vmi Holland B.V. Device and methods for packaging medicaments with fault detection

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS582724Y2 (en) * 1978-11-01 1983-01-18 株式会社新日本 Film tube forming equipment for food packaging machines
IT1173194B (en) * 1984-02-02 1987-06-18 Padeco Sa PROCEDURE AND EQUIPMENT FOR PACKING ITEMS OF ANY SHAPE INTO AN EXTENSIBLE PLASTIC FILM
JPH0161006U (en) * 1987-10-12 1989-04-18
JPH0632303U (en) * 1992-10-01 1994-04-26 日東精工株式会社 Automatic packaging equipment
US6371644B1 (en) * 1997-05-22 2002-04-16 Sealstrip Corp. Reclosable seal, package, method and apparatus
JPH11301622A (en) * 1998-04-17 1999-11-02 Tokyo Autom Mach Works Ltd Vertical bag-making, filling and packaging machine
JP2010082052A (en) * 2008-09-30 2010-04-15 Sanyo Electric Co Ltd Medicine supply apparatus
NL2007384C2 (en) 2011-09-09 2013-03-12 Ppm Engineering B V SYSTEM AND METHOD FOR PACKING DOSED QUANTITIES OF SOLID MEDICINES
JP2013166580A (en) 2012-02-16 2013-08-29 Tokyo Institute Of Technology Bag making-filling-packaging device
US10427809B2 (en) * 2012-06-01 2019-10-01 Rxsafe Llc Pharmacy packaging system
JP6128954B2 (en) 2013-05-23 2017-05-17 株式会社東京自働機械製作所 Vertical bag making and filling machine
US9238537B2 (en) * 2013-06-10 2016-01-19 Frito-Lay North America, Inc. Method for producing multi-compartment packages
CN204124437U (en) * 2014-09-13 2015-01-28 王颖 Seal packing machine is stitched in vertical intermittent bag
CN105416644A (en) * 2015-12-07 2016-03-23 无锡市医用仪表厂 Vertical roller blister packaging machine
CN205469951U (en) * 2016-01-13 2016-08-17 上海金滩龙机械有限公司 High -speed full -automatic vertical packaging machine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

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Publication number Publication date
AU2018249339B2 (en) 2023-07-06
KR20190134644A (en) 2019-12-04
CA3056480A1 (en) 2018-10-11
JP2023025121A (en) 2023-02-21
AU2018249339A1 (en) 2019-10-31
BR112019020156A2 (en) 2020-04-22
DK3385174T3 (en) 2019-10-28
JP2020516546A (en) 2020-06-11
CN110536838A (en) 2019-12-03
KR102532860B1 (en) 2023-05-15
JP7497412B2 (en) 2024-06-10
EP3385174A1 (en) 2018-10-10
WO2018184795A1 (en) 2018-10-11
BR112019020156B1 (en) 2023-10-10

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