WO2018174050A1 - Outil d'aide au mélange et système de seringue - Google Patents

Outil d'aide au mélange et système de seringue Download PDF

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Publication number
WO2018174050A1
WO2018174050A1 PCT/JP2018/010994 JP2018010994W WO2018174050A1 WO 2018174050 A1 WO2018174050 A1 WO 2018174050A1 JP 2018010994 W JP2018010994 W JP 2018010994W WO 2018174050 A1 WO2018174050 A1 WO 2018174050A1
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WO
WIPO (PCT)
Prior art keywords
syringe
base end
barrel
mixing aid
finger
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Application number
PCT/JP2018/010994
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English (en)
Japanese (ja)
Inventor
沖原等
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2019507686A priority Critical patent/JP6975226B2/ja
Publication of WO2018174050A1 publication Critical patent/WO2018174050A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons

Definitions

  • the present invention relates to a mixing aid and a syringe system used when mixing medicines in two syringes.
  • a syringe kit for mixing two drugs for mixing drugs in two syringes is known (for example, see JP2013-132349A).
  • this type of syringe kit in order to mix the drugs in the two syringes, the barrels of the two syringes are connected to each other, and the pusher of one syringe is pushed, so Is transferred to the barrel of the other syringe.
  • the drug when transferring the drug from one barrel to the other, the drug cannot be transferred due to the resistance of the gasket in the other barrel, or the transfer takes time. There is. In particular, in the case of a powder with a lot of air in the syringe, the buffer due to the compression of air is large, and it takes time to shift.
  • the present invention has been made in consideration of such problems, and an object thereof is to provide a mixing aid and a syringe system capable of shortening the mixing time of a medicine using a syringe kit.
  • the present invention provides a mixing aid that can be attached to a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a medicine,
  • a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a medicine,
  • Each has a barrel having a finger grip projecting radially outward at the proximal end, a gasket slidably disposed within the barrel, and a pusher proximal end connected to the gasket and at the proximal end A pusher protruding in the proximal direction from the proximal end opening of the barrel, the finger grip is formed in a non-circular shape having a short axis and a long axis, and the two auxiliary syringes are connected to each other.
  • 2 mounting portions, and a rod-shaped connecting portion that connects the first mounting portion and the second mounting portion, and the width of the connecting portion in the direction perpendicular to the longitudinal direction of the mixing aid is The finger grip is smaller than the length of the finger grip along the long axis, and the one and the other pusher base end portions are respectively attached to the first attachment portion and the second attachment portion. It protrudes outward from the connecting portion.
  • the pushers of the two syringes are connected to each other by the mixing aid. Therefore, when an operation of pushing one pusher in the distal direction is performed, the other pusher is simultaneously performed. The operation of pulling in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pusher as in the case where the mixing aid is not used, the mixing can be performed with the same operation feeling.
  • the connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and each of the two connecting members The other end side is connected to the second mounting portion, and the syringe kit is disposed between the two connecting members in a state where the connected syringe kit is mounted on the mixing aid. May be.
  • This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
  • the first mounting part and the second mounting part include a finger support part that supports the base end surface of the pusher base end part and is pressed with a finger, and the length of the mixing assisting tool of the finger support part
  • the width in the direction perpendicular to the direction may be larger than the diameter of the pusher base end and smaller than the length of the finger grip along the major axis.
  • the finger holder since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
  • the mixing aid may be deformable into a first form in which the syringe kit in a connected state can be mounted and a second form having a shorter overall length than the first form.
  • This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
  • the connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member rotate with each other via a hinge portion. It may be movably connected.
  • the present invention provides a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a drug and a syringe kit in which the two syringes are connected to each other.
  • Each of the two syringes is connected to the gasket, a barrel having a finger grip at a proximal end, a gasket slidably disposed in the barrel, and a syringe system.
  • the mixing assisting tool includes a first mounting portion on which one of the pusher base end portions of the syringe kit in the connected state can be mounted, and the other of the syringe kit in the connected state.
  • the width in the direction perpendicular to the direction is smaller than the length of the pusher base end portion along the major axis, and one and the other pusher base end portions are provided on the first mounting portion and the second mounting portion.
  • the finger grip protrudes outward from the connecting portion in a mounted state.
  • the connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and the two The other end side of each connecting member is connected to the second mounting part, and the syringe kit is connected to the two connecting members in a state where the connected syringe kit is mounted to the mixing aid. It may be arranged between.
  • This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
  • the first mounting portion and the second mounting portion include a finger support portion that supports a base end surface of the pusher base end portion and is pressed with a finger
  • the finger support portion includes: The width in the direction perpendicular to the longitudinal direction of the mixing aid may be larger than the diameter of the pusher base end portion and smaller than the length of the finger grip along the major axis.
  • the finger holder since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
  • the mixing aid may be deformable into a first form in which the connected syringe kit can be mounted and a second form in which the overall length is shorter than that in the first form.
  • This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
  • the connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member are hinge portions. It may be connected so that rotation is possible mutually.
  • air in the initial state of the syringe kit, air may be contained in the filling space formed on the tip side of the gasket in the barrel of at least one of the two syringes.
  • a tip of the barrel of the two syringes is provided with a screwing projection that can be screwed together, and a flange that protrudes radially outward is provided at the base end of the barrel.
  • the finger grip provided may be a grip member attached to the flange portion so as to be rotatable about an axis of the barrel.
  • the finger grip can be easily and reliably protruded outside the connecting portion regardless of the screwing state of the screwing protrusion.
  • the mixing aid and syringe system of the present invention it is possible to shorten the mixing time of the medicine using the syringe kit.
  • FIG. 1 is a perspective view of a syringe system according to a first embodiment of the present invention. It is a perspective view of a syringe kit (before connection). It is a top view of the syringe system shown in FIG. FIG. 4 is a sectional view taken along line IV-IV in FIG. 3. It is a perspective view of a syringe kit (after connection). It is explanatory drawing when the length of a syringe kit and a mixing aid differs. It is a perspective view of the syringe system which concerns on 2nd Embodiment of this invention. It is a perspective view of the state which bent the mixing auxiliary tool of the syringe system shown in FIG.
  • a syringe system 10 according to the first embodiment shown in FIG. 1 is a device for mixing a filler in one barrel and a filler in the other barrel.
  • the syringe system 10 can be equipped with a syringe kit 12 including two syringes whose tip portions can be connected to each other for mixing the medicine M, and a connected syringe kit 12 in which two syringes are connected to each other.
  • FIG. 1 shows a state where the syringe kit 12 is attached to the mixing aid 14.
  • the syringe kit 12 includes a male syringe 16 and a female syringe 18 that can be screwed together. Both the male syringe 16 and the female syringe 18 are configured as prefilled syringes pre-filled with contents such as drugs.
  • the side connected to the female syringe 18 or the direction thereof is referred to as “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as “base end portion” or “ It is called “proximal direction”.
  • the side connected to the male syringe 16 or the direction thereof is referred to as a “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as a “base end portion” or “base end direction”.
  • the male syringe 16 is connected to the barrel 20 for a male syringe made of a hollow body, a gasket 22 slidably inserted into the barrel 20 for a male syringe, and the gasket 22.
  • a pusher 24A and a medicine M filled in a filling space 21 formed by a barrel 20 for a male syringe and a gasket 22 are provided.
  • male syringe barrel 20 is abbreviated as “male barrel 20”.
  • the male barrel 20 has a substantially cylindrical shape and a barrel body 20a having a proximal end formed at the proximal end, a nozzle 20b provided at the distal end of the barrel body 20a, and a lock provided outside the nozzle 20b. It has an adapter 20c, a flange 20f projecting radially outward from the base end of the barrel body 20a, and a finger grip 26A provided at the base end of the barrel body 20a.
  • the barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f are integrally formed.
  • the barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f constitute a male barrel main body.
  • the nozzle 20b is reduced in diameter with respect to the barrel barrel 20a from the center of the tip of the barrel barrel 20a and extends in the tip direction.
  • the nozzle 20b has a passage 20g (see FIG. 4) penetrating in the axial direction and communicating with the inner cavity (filling space 21) of the barrel body 20a.
  • the nozzle 20b is configured as a male luer having a circular outer cross section and a tapered outer peripheral surface 20bs whose outer diameter decreases toward the tip.
  • the nozzle 20b can be fitted to a cylinder portion 40b (mesluer), which will be described later, of the female syringe 18.
  • the lock adapter 20c is formed in a substantially hollow cylindrical shape extending from the tip of the barrel body 20a in the tip direction and concentrically surrounding the nozzle 20b.
  • a screw 20e is formed on the inner peripheral surface of the lock adapter 20c.
  • the flange portion 20f has a non-circular shape in which portions on opposite sides of a circular outer peripheral portion are cut into a straight line.
  • the gasket 22 is inserted into the barrel body 20a through a proximal end opening that opens at the proximal end of the barrel body 20a.
  • the gasket 22 seals the base end side of the barrel body 20a in a liquid-tight manner.
  • the gasket 22 is made of an elastic material such as a rubber material.
  • the outer periphery of the gasket 22 is in liquid-tight contact with the inner peripheral surface of the barrel body 20a, and is slidably disposed in the barrel body 20a.
  • a gasket 22 is connected to the tip of the pusher 24A.
  • the pusher 24A has a shaft portion 28A having a distal end portion connected to the gasket 22, and a pusher base end portion 30A provided at the base end of the shaft portion 28A.
  • the pusher base end portion 30A is formed in a flange shape projecting radially outward from the base end of the shaft portion 28A.
  • the finger grip 26A is a grip member 27A attached to the flange portion 20f so as to be rotatable around the axis of the male barrel 20.
  • the grip member 27 ⁇ / b> A has a base portion 32 attached to the proximal end portion of the male barrel 20 and a pair of finger hook portions 34 protruding in opposite directions, and the short shaft as viewed from the axial direction of the male barrel 20. It is formed in a non-circular shape having a long axis.
  • the finger grip 26 ⁇ / b> A has a U-shaped flange mounting groove 36. By inserting (fitting) the flange portion 20f into the flange mounting groove 36, the male barrel 20 and the grip member 27A are fixed so as not to be relatively movable in the axial direction.
  • a medical liquid ML specifically, a solution such as physiological saline
  • a powdered medicine a freeze-dried medicine, or the like.
  • Any solid drug, liquid drug, etc. may be used.
  • examples of such a drug M include protein preparations, peptide preparations, antitumor agents, vitamin agents (general vitamin agents), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, analgesics, cardiotonics, Note: Anesthetic agents, medical narcotics, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents and the like.
  • a cap (not shown) is attached to the nozzle 20b, and the tip opening 20b1 of the nozzle 20b is sealed by this cap. This cap is removed from the nozzle 20b when the male syringe 16 is used (when the syringe kit 12 is used).
  • the female syringe 18 has a female syringe barrel 40 made of a hollow body, a gasket 42 slidably inserted into the female syringe barrel 40, a pusher 24B connected to the gasket 42, and a female syringe barrel 40. And a medical liquid ML filled in a filling space 43 formed by the gasket 42.
  • female barrel 40 is abbreviated as “female barrel 40”.
  • the female barrel 40 has a substantially cylindrical shape and a barrel body 40a having a proximal end formed at the proximal end, a cylindrical portion 40b protruding from the distal end of the barrel body 40a in the distal direction, and a base of the barrel body 40a.
  • the flange portion 40f is formed to protrude radially outward from the end, and the finger grip 26B is attached to the proximal end portion of the barrel body portion 40a.
  • the barrel body 40a, the cylinder portion 40b, and the flange portion 40f constitute a female barrel main body.
  • the tube portion 40b extends from the tip of the barrel body 40a in the tip direction.
  • the cylinder part 40b has a passage that penetrates in the axial direction and communicates with the inner cavity (filling space 43) of the barrel body part 40a.
  • the cylindrical portion 40b is configured as a female luer having a tapered inner peripheral surface 40bs (see also FIG. 4) whose outer diameter increases in the distal direction.
  • Two protrusions 40d projecting outward (radially outward) opposite to each other with respect to the axis (center line) of the cylindrical portion 40b are provided on the outer periphery of the distal end of the cylindrical portion 40b.
  • the two protrusions 40d can be screwed with a screw 20e provided on the lock adapter 20c of the male barrel 20.
  • the flange portion 40f has a non-circular shape in which portions on opposite sides of the circular outer peripheral portion are cut in a straight line.
  • the gasket 42 is inserted into the barrel body 40a through a proximal end opening that opens at the proximal end of the barrel body 40a.
  • the gasket 42 seals the base end side of the barrel body 40a in a liquid-tight manner.
  • the gasket 42 is made of an elastic material such as a rubber material.
  • the gasket 42 is disposed so that its outer peripheral portion is in liquid-tight contact with the inner peripheral surface of the barrel barrel 40a and is slidable within the barrel barrel 40a.
  • a gasket 42 is connected to the tip of the pusher 24B.
  • the pusher 24B has a shaft portion 28B having a distal end portion connected to the gasket 42, and a pusher base end portion 30B provided at the base end of the shaft portion 28B.
  • the pusher base end portion 30B is formed in a flange shape protruding radially outward from the base end of the shaft portion 28B.
  • the finger grip 26B is a grip member 27B attached to the flange portion 40f so as to be rotatable about the axis of the knife barrel 40.
  • the grip member 27 ⁇ / b> B has a base portion 46 attached to the proximal end portion of the female barrel 40 and a pair of finger hook portions 48 protruding in opposite directions from the base portion 46, as viewed from the axial direction of the female barrel 40.
  • the non-circular shape has a short axis and a long axis.
  • the finger grip 26 ⁇ / b> A has a U-shaped flange mounting groove 50.
  • a cap (not shown) is attached to the tube portion 40b, and the tip opening of the tube portion 40b is sealed by this cap. This cap is removed from the cylindrical portion 40b when the female syringe 18 is used (when the syringe kit 12 is used).
  • the medical liquid ML is a liquid that can dissolve, dilute, or mix the drug M in the male syringe 16.
  • a medical liquid ML may be a drug solution such as physiological saline, a drug diluent, a drug mixture, or a drug solution containing a drug (for example, a vitamin or mineral).
  • the medical liquid ML is not filled in the female syringe 18 in advance as in the present embodiment, but may be aspirated in a necessary amount into the empty female syringe 18 from a vial or the like as necessary.
  • the male barrel 20 and the female barrel 40 are made of a hard material having transparency.
  • Examples of the constituent material of the male barrel 20 and the female barrel 40 include cyclic polyolefin, polypropylene, and polycarbonate.
  • air is contained in the filling space formed on the tip side of the gasket in at least one of the male syringe 16 and the female syringe 18.
  • the mixing assisting tool 14 includes a first mounting portion 54 ⁇ / b> A on which one pusher base end portion 30 ⁇ / b> A of the connected syringe kit 12 can be mounted, and a connected syringe kit.
  • the connecting portion 58 has two connecting members 60 extending to face each other.
  • 54 A of 1st mounting parts, the 2nd mounting part 54B, and the connection part 58 are integrally molded by injection molding etc., for example.
  • the pusher proximal end 30A of the male syringe 16 is attached to the first attachment portion 54A
  • the pusher proximal end 30B of the female syringe 18 is attached to the second attachment portion 54B.
  • the state is shown.
  • the pusher base end 30A of the male syringe 16 may be mounted on the second mounting portion 54B
  • the pusher base end 30B of the female syringe 18 may be mounted on the first mounting portion 54A.
  • the first mounting portion 54A and the second mounting portion 54B are opposed to each other with an interval in the longitudinal direction of the mixing aid 14. Since the first mounting portion 54A and the second mounting portion 54B are configured in the same shape, the configuration of the first mounting portion 54A will be typically described below.
  • the first mounting portion 54 ⁇ / b> A supports the proximal end surface of the pusher proximal end portion 30 ⁇ / b> A and pushes between the finger holding portion 62 pressed by the finger and the finger holding portion 62.
  • a holding portion 64 that holds the child base end portion 30A.
  • the finger contact portion 62 has a flange contact surface 62a that contacts the proximal end surface of the pusher proximal end portion 30A, and a finger contact surface 62b that is formed on the opposite side of the flange contact surface 62a and is pressed by a finger. Is provided.
  • the finger holder 62 is formed in a circular plate shape. As shown in FIG. 3, the width Wf of the finger holder 62 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is larger than the diameter D (see FIG. 2) of the pusher base end 30A, and the finger grip It is smaller than the length La along the long axis of 26A.
  • the sandwiching portion 64 has a pair of engaging protrusions 64 a that protrude from the connecting portion 58 to face each other.
  • a slit 64b (gap) is formed between the pair of engaging protrusions 64a.
  • the shaft portion 28A of the pusher 24A is disposed (inserted) in the slit 64b.
  • the width of the clamping part 64 is smaller than the width Wf of the finger holding part 62.
  • the finger contact surface 62b of the finger holder 62 is provided with a locking projection 68 that can be engaged with the outer peripheral portion of the pusher base end 30A.
  • the pusher proximal end 30A is located between the finger holding portion 62 and the clamping portion 64 from the side opposite to the side where the locking projection 68 is provided. Inserted into. At that time, the position of the pusher 24 with respect to the first mounting portion 54 ⁇ / b> A is positioned at an appropriate position by the locking protrusion 68.
  • the two connecting members 60 constituting the connecting portion 58 extend in a straight line between the first mounting portion 54A and the second mounting portion 54B in parallel with each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B.
  • the syringe kit 12 is disposed between the two connecting members 60. That is, the mixing aid 14 has a rectangular frame shape by the two connecting members 60, the first mounting portion 54A, and the second mounting portion 54B, and the syringe kit 12 is arranged inside the frame shape. It is configured.
  • the width W of the connecting portion 58 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B. Accordingly, the finger grips 26A and 26B protrude outward from the connecting portion 58 in a state where the first and second pusher base end portions 30A and 30B are attached to the first attachment portion 54A and the second attachment portion 54B. .
  • the mixing aid 14 is made of a hard material.
  • Examples of the constituent material of the mixing aid 14 include cyclic polyolefin, polypropylene, and polycarbonate.
  • the mixing aid 14 may be made of a metal material.
  • caps are respectively removed (opened) from the nozzle 20b of the male barrel 20 and the cylindrical portion 40b of the female barrel 40.
  • the male barrel 20 and the female barrel 40 are connected to each other.
  • the screw 20e (FIG. 2) of the lock adapter 20c and the protrusion 40d (FIG. 2) provided on the cylindrical portion 40b of the female barrel 40 are screwed together.
  • the nozzle 20b (male lure) of the male barrel 20 is inserted into the cylinder part 40b (male luer) of the female barrel 40.
  • the tapered outer peripheral surface 20bs (FIG. 2) of the nozzle 20b is liquid-tightly fitted to the tapered inner peripheral surface 40bs (FIG. 2) of the cylindrical portion 40b.
  • the syringe kit 12 in a state where the male syringe 16 and the female syringe 18 are connected to each other is attached to the mixing aid 14.
  • the pusher base end portions 30A and 30B of the male syringe 16 and the female syringe 18 are inserted and attached to the first mounting portion 54A and the second mounting portion 54B, respectively.
  • the syringe kit 12 is disposed between the two connecting members 60 constituting the connecting portion 58, and the pair of finger hanging portions 34 and the pair of finger hanging portions 48 from between the two connecting members 60 are more than the connecting portion 58. It will be in the state which protrudes outside, respectively.
  • the medical liquid ML and the medicine M are mixed by performing a pumping operation using the pusher 24A of the male syringe 16 and the pusher 24B of the female syringe 18.
  • the finger holding unit 62 of the second mounting portion 54B is moved to the first position with another finger (for example, the thumb) of the same hand.
  • the pusher 24B of the female syringe 18 is pressed toward the distal end of the female syringe 18 via the second mounting portion 54B.
  • the finger mounting portion 62 of the first mounting portion 54A is secondly mounted with another finger (for example, the thumb) of the same hand.
  • the pusher 24A of the male syringe 16 is pressed toward the distal end of the male syringe 16 via the first mounting part 54A.
  • the liquid mixture a mixture of the medical liquid ML and the medicine M
  • dissolution, dilution or mixing of the drug M is promoted, and a desired drug solution is adjusted.
  • the syringe system 10 according to the first embodiment has the following effects.
  • the pushers 24 ⁇ / b> A and 24 ⁇ / b> B of the two syringes 16 and 18 are connected to each other by the mixing assisting tool 14, so when an operation of pushing one pusher in the distal direction is performed, An operation in which the child is pulled in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pushers 24A and 24B as in the case where the mixing aid 14 is not used, the mixing can be performed with the same operation feeling as in the conventional case.
  • the connecting portion 58 has two connecting members 60 extending to face each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B. And the syringe kit 12 is arrange
  • Each of the first mounting portion 54A and the second mounting portion 54B has a finger contact portion 62 that supports the proximal end surface of the pusher proximal end portion 30A and is pressed with a finger.
  • the width W of the finger holder 62 is larger than the diameter D of the pusher base end portions 30A and 30B and smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B.
  • Finger grips 26A and 26B are grip members 27A and 27B attached to flange portions 26d and 40f so as to be rotatable about the axis of the barrel. With this configuration, the grip members 27A and 27B can be easily and reliably protruded to the outside of the connecting portion 58 regardless of the screwing state of the screwing protrusions (screws 20e and protrusions 40d).
  • the flange portions 26d and 40f of the male barrel 20 and the female barrel 40 have a non-circular shape having a major axis and a minor axis.
  • the direction of the rotation direction may be different from the flange portion 40f.
  • the grip members 27A and 27B can rotate with respect to the male barrel 20 and the female barrel 40, respectively, the syringe kit 12 is mixed with the mixing aid 14 after adjusting the direction of the rotation direction of the grip members 27A and 27B.
  • the grip members 27A and 27B can be reliably projected outward from the connecting portion 58.
  • the grip members 27 ⁇ / b> A and 27 ⁇ / b> B can be reliably put on the fingers, and the mixing operation can be performed smoothly.
  • the total length L1 of the syringe kit 12 with the male syringe 16 and the female syringe 18 connected to each other is different from the length L2 between the first mounting portion 54A and the second mounting portion 54B.
  • FIG. 6 shows a case where L1 is longer than L2, conversely, L1 may be shorter than L2.
  • air is contained in the filling space formed on the tip side of the gasket in at least one barrel of the male syringe 16 and the female syringe 18.
  • the pusher (the pusher 24A or the pusher 24B) can be moved in the axial direction to some extent by the compression or expansion of the air existing in the filling space. Therefore, the syringe kit 12 can be attached to the mixing aid 14 without forcibly deforming the connecting portion 58.
  • the mixing aid 14 a of the syringe system 10 a has a first form (FIG. 7) in which the connected syringe kit 12 can be mounted and a shorter overall length than the first form.
  • the second form (FIG. 8) can be modified. With this configuration, the mixing aid 14a can be stored in a compact form in the second form before the use of the mixing aid 14a. Further, after use, the mixing aid 14a can be deformed from the first form to the second form and discarded compactly.
  • the connecting portion 58 of the mixing aid 14a includes a first member 70 having a first mounting portion 54A and a second member 72 having a second mounting portion 54B.
  • the first member 70 and the second member 72 are connected to each other via a hinge portion 74 so as to be rotatable.
  • the mixing aid 14 a is configured to be foldable in a shape that can be folded at an intermediate portion of the connecting portion 58.
  • the second member 72 is configured to be shorter than the first member 70.
  • the first mounting part 54A and the second mounting part 54B are arranged so as to be shifted in the longitudinal direction of the mixing assisting tool 14a, and A part of the second mounting portion 54B is inserted between the connecting members 60 on the first member 70 side.
  • variety of the mixing auxiliary tool 14a in a folded state can be made smaller, and further compactification is achieved.
  • the pusher base end portions 30A and 30B may not have a flange shape.
  • the shaft portion 28A and the pusher base end portion 30A of the pusher 24A may be formed in an integral cylindrical shape (the same applies to the pusher 24B).
  • a notch portion is provided on the outer peripheral surface of each pusher base end portion 30A, 30B, and a protrusion that can be inserted into the notch portion serves as a first mounting portion 54A and a second mounting portion 54B. 14.
  • the insertion opening part is provided in the base end surface of each pusher base end part 30A, 30B, and the insertion auxiliary

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Un outil d'aide au mélange (14) qui comprend : une première partie de montage (54A) au niveau de laquelle une partie de base de piston (30A) d'un kit de seringue (12) peut être montée; une seconde partie de montage (54B) au niveau de laquelle une autre partie de base de piston (30B) du kit de seringue (12) peut être montée; et une partie de liaison (58) en forme de tige qui relie la première partie de montage (54A) et la seconde partie de montage (54B). La largeur de la partie de liaison (58) est inférieure à la longueur d'axe majeur des pinces à doigts (26A, 26B). Lorsque la première et l'autre partie de base de piston (30A, 30B) ont été montées au niveau de la première partie de montage (54A) et de la seconde partie de montage (54B), les pinces à doigts (26A, 26B) font saillie davantage vers l'extérieur que la partie de liaison (58).
PCT/JP2018/010994 2017-03-23 2018-03-20 Outil d'aide au mélange et système de seringue WO2018174050A1 (fr)

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JP2019507686A JP6975226B2 (ja) 2017-03-23 2018-03-20 混合補助具及びシリンジシステム

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JP2017-056807 2017-03-23

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265764A (zh) * 2020-03-23 2020-06-12 淄博科创医疗仪器有限公司 吸射两用注射助推器

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Publication number Priority date Publication date Assignee Title
US3035820A (en) * 1960-03-23 1962-05-22 Allergy Section Of The Res Fou Emulsification apparatus
US3071351A (en) * 1960-10-25 1963-01-01 Ethan A Brown Emulsor
JPS4970562U (fr) * 1972-10-03 1974-06-19
WO2002058834A1 (fr) * 2001-01-26 2002-08-01 Howmedica Osteonics Corp. Dispositif de melange et de distribution de ciment
WO2005118118A2 (fr) * 2004-06-02 2005-12-15 William Mccoy Méthode et appareil de composition de médicaments
WO2007083763A1 (fr) * 2006-01-23 2007-07-26 Greenpeptide Co., Ltd. Procédé de production d'une préparation sous forme d'émulsion contenant un peptide physiologiquement actif, et trousse destinée à la production de ladite préparation
WO2010027107A1 (fr) * 2008-09-05 2010-03-11 オンコセラピー・サイエンス株式会社 Dispositif et procédé pour préparer automatiquement un médicament en émulsion
JP2013132349A (ja) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd 二薬混合用シリンジキット

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035820A (en) * 1960-03-23 1962-05-22 Allergy Section Of The Res Fou Emulsification apparatus
US3071351A (en) * 1960-10-25 1963-01-01 Ethan A Brown Emulsor
JPS4970562U (fr) * 1972-10-03 1974-06-19
WO2002058834A1 (fr) * 2001-01-26 2002-08-01 Howmedica Osteonics Corp. Dispositif de melange et de distribution de ciment
WO2005118118A2 (fr) * 2004-06-02 2005-12-15 William Mccoy Méthode et appareil de composition de médicaments
WO2007083763A1 (fr) * 2006-01-23 2007-07-26 Greenpeptide Co., Ltd. Procédé de production d'une préparation sous forme d'émulsion contenant un peptide physiologiquement actif, et trousse destinée à la production de ladite préparation
WO2010027107A1 (fr) * 2008-09-05 2010-03-11 オンコセラピー・サイエンス株式会社 Dispositif et procédé pour préparer automatiquement un médicament en émulsion
JP2013132349A (ja) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd 二薬混合用シリンジキット

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265764A (zh) * 2020-03-23 2020-06-12 淄博科创医疗仪器有限公司 吸射两用注射助推器
CN111265764B (zh) * 2020-03-23 2024-05-28 淄博科创医疗仪器有限公司 吸射两用注射助推器

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JP6975226B2 (ja) 2021-12-01

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