WO2018161938A1 - 一种调节女性阴道微生态的妇科阴道洗液及其制备方法 - Google Patents

一种调节女性阴道微生态的妇科阴道洗液及其制备方法 Download PDF

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WO2018161938A1
WO2018161938A1 PCT/CN2018/078433 CN2018078433W WO2018161938A1 WO 2018161938 A1 WO2018161938 A1 WO 2018161938A1 CN 2018078433 W CN2018078433 W CN 2018078433W WO 2018161938 A1 WO2018161938 A1 WO 2018161938A1
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water
vaginal
acidic
acid
micro
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PCT/CN2018/078433
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English (en)
French (fr)
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李少平
渠志灿
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山西纳安生物科技有限公司
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Priority to US16/338,691 priority Critical patent/US20220257479A1/en
Publication of WO2018161938A1 publication Critical patent/WO2018161938A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin

Definitions

  • the invention belongs to the field of health care and medical technology, and particularly relates to a gynecological vaginal washing liquid for regulating female vaginal micro-ecology and a preparation method thereof.
  • the female lower genital tract is an open cavity, which is an important micro-ecological zone in the human body. Under normal circumstances, it is a micro-ecological system composed mainly of dominant bacteria.
  • Female vaginal micro-ecological imbalance is the main cause of recurrent episodes of gynecological vulva and vaginal inflammation.
  • estrogen, lactobacilli and vaginal pH (PH) play a crucial role.
  • estrogen makes the vaginal epithelial hyperplasia thicker and rich in glycogen, increasing the resistance to pathogens; glycogen is decomposed into lactic acid under the action of Lactobacillus vaginalis, maintaining the normal acidic environment of the vagina (pH ⁇ 4.5) , mostly in 3.8 ⁇ 4.4), inhibit the growth of other parasitic bacteria and their pathogens, which is the self-purification of the vagina.
  • vaginal microecology research The normal flora in the vagina is the core of vaginal microecology research. Deerlein first published research on human vaginal microecological flora as early as 1892. Later, it was found that the vaginal flora of healthy women consisted of a variety of anaerobic and aerobic bacteria. At present, 29 kinds of microorganisms have been isolated from vaginal secretions, the most important of which is Lactobacillus, which has a separation rate of 50% to 80% in vaginal discharge specimens of healthy women. It produces some antimicrobial substances, including lactic acid, bacteriocin, lactate B and hydrogen peroxide. Hydrogen peroxide-producing lactobacilli play an important role in controlling the vaginal micro-ecological environment and inhibit the excessive growth of other pathogens by acting in combination with other peroxides.
  • vaginal epithelial cells follow menstruation During the cycle, the effects of estrogen and progesterone occur periodically, especially in the surface cells. The cells are rich in glycogen. After glycogen secretion, they are broken down into lactic acid by the action of vaginal bacteria parasitic in the vagina. Maintaining an acidic environment with a pH of 4.5 to inhibit the growth of pathogenic bacteria, the normal vaginal fluid has self-cleaning or sterilization.
  • vaginal cleanliness The normal PH value of vaginal secretions is 3.8. When pH is 3.8-4.2, it is beneficial to the reproduction of commensal bacteria, especially Lactobacillus, which is the main strain in healthy vagina.
  • the density in vaginal fluid can reach 105 ⁇ 108ml, when the vagina is infected by microorganisms, if the lactobacilli predominate, still maintain the pH of 3.8 ⁇ 4.2, it will not cause disease, and Lactobacillus can also produce H 2 O 2 , which is toxic to other microorganisms. Inhibit its reproduction.
  • Lactobacillus regulates the normal vaginal flora by both positive and negative aspects.
  • vaginal microecological balance is broken or the invasion of foreign pathogens can lead to inflammation, such as changes in estrogen levels or elevated vaginal pH; abuse or use of antibiotics can cause resistance to the bacteria and kill a large number of beneficial bacteria, destroying The balance of vaginal flora leads to strong fungal growth, and gynecological diseases are stubborn and difficult to completely cure.
  • trichomonas vaginitis which is caused by Trichomonas vaginalis, and the pathogen causing trichomonas vaginitis is a suitable environment with a pH between 5.2 and 6.6, so many clinically Women with gynecological diseases are always troubled by the recurrence of the disease after menstruation.
  • the pH value of the vagina is very important, which will be beneficial to the prevention of gynecological diseases, and the pH value of the vagina is weakly acidic. It also tells everyone that washing the vagina with alkaline substances often destroys the weak acidic environment of the vagina. And is conducive to bacterial reproduction.
  • the pH of the vagina is acidic. Normal people's vaginal PH value ⁇ 4.5, mostly in the 3.8-4.4. When suffering from vaginal inflammation, the pH value of the vagina will change, and the change of its value is closely related to the pathogen causing inflammation. The pathogen is different, the degree of inflammation is different, and the PH value is also different.
  • vaginal pH After menstruation and after sex, the vaginal pH will deviate from the normal range, which is conducive to bacterial reproduction.
  • vaginal microenvironment improving the vaginal microenvironment, repairing vaginal micro-injury, maintaining vaginal micro-ecological balance, improving vaginal cleanliness, and improving vaginal mucosal immunity are important for treating common vaginal diseases in women, and should be considered to avoid the use of antibiotics.
  • the gynecological gels appearing on the market are mostly Chinese medicine ingredients, and mainly aim at treating gynecological diseases by inhibiting harmful pathogens. While killing pathogenic bacteria, they also kill many probiotics, leading to vaginal flora imbalance. Vaginal immunity is low, which causes recurrent vaginitis and cannot be cured.
  • Electrolytic functional water is a special function of acidic water and alkaline produced by changing the pH, redox potential (ORP), and effective chlorine concentration (ACC) of water to a dilute solution of electrolyte in a special device.
  • ORP redox potential
  • ACC effective chlorine concentration
  • the general term for water According to its physical and chemical properties, it can be divided into electrolytic strong acid functional water, electrolytic slightly acidic functional water, electrolytic weak alkaline functional water and electrolytic alkaline ionized water.
  • Acidic oxidation potential water is a general term for all kinds of artificial electrolysis strong functional water. It includes electrolytically strong acidic water, electrolytic weakly acidic water, ionized acidic water and artificial hydrogen-rich nanobubble acidic water.
  • the pH of the artificially electrolyzed strongly acidic water is usually between 2.0 and 3.5, and has a high oxidation-reduction potential value, generally 1000 to 1200 mV, and an effective chlorine concentration of 20 to 200 mg/L.
  • Artificial electrolytic acid water (including strong acidic water and slightly acidic water) has disinfection and sterilization function, mainly used for fresh-keeping of fruits and vegetables, production of sprouts, preservation of fresh cut flowers, disinfection of equipment, degradation of toxins, livestock breeding and plant protection, etc. field.
  • the bactericidal mechanism of artificially oxidized acidic water mainly includes free radical theory, effective chlorine theory, and strong oxidation theory of redox potential.
  • artificially electrolyzed weakly acidic water is usually between 3.5 and 6.0.
  • artificially acidic water is defined as: adding a small amount of sodium chloride (with a NaCl concentration of 0.2% or less) to electrolysis in an electrolytic cell having a separator.
  • Most of the artificial weakly-electrolyzed acidic water is used for drinking, food cleaning and soaking and disinfection with human or animal contact.
  • Artificial strong electrolytic acid water is used for disinfection and cleaning of industrial and medical equipment.
  • hypochlorous acid HOCl or HClO
  • ionized water that is, the activated carbon is used as a filter layer through the water purifier, the tap water is filtered to purify it to the standard (up to the national water standard), and then two kinds of active water, ie, ionized water, are generated by the decidual membrane electrolysis. It is ionized alkaline ionized water; concentrated on the anode is ionized acidic ionized water.
  • Ionic water is essentially water, and nothing is added except for the loss of electrons. Ionized water gradually (reduced) into ordinary water due to contact with air or other substances during use. Ionized water is produced by ionization. The process is that ordinary tap water is purified into a high-efficiency ionization tank to ionize the water, and the positive and negative ions are separated by high-tech means. Ionic water (intensity and weakness), molecular group (size), solubility (size) conductivity (high and low), pH (size), surface tension, density, thermal conductivity, oxygen content, etc. Not the same. Therefore, the activity of ionized water is much stronger than ordinary water (including mineral water, pure water).
  • Ionized acidic ionized water is generally considered to contain hydrogen ions (H4O9+) to form low-pH acidic water, also known as oxidized water. Ionized water is a unique medical care, and cosmetic anti-inflammatory and bactericidal effects are not found in ordinary water. The application of ionized water in industry and agriculture is still in the process of continuous development.
  • Nanobubble-rich hydrogen acid water is water containing a large amount of nanobubble-rich hydrogen bubbles, which contains water with a higher hydrogen concentration than ordinary hydrogen water. Its hydrogen concentration is approximately 1/20 or higher of the saturation concentration.
  • bubbles can be encountered in many processes in nature.
  • CMB centimeter bubbles
  • MMB millimeter bubbles
  • MNB microbubbles
  • nanobubbles nanobubbles according to the order from large to small.
  • NB micro-nano bubbles
  • the so-called micro-nano bubbles refer to bubbles with a diameter between 10 microns and hundreds of nanometers.
  • the bubbles are between micro-bubbles and nano-bubbles, and have physical and chemical properties not found in conventional bubbles. .
  • Characteristics of micro-nano bubbles 1. Large specific surface area.
  • the relationship between the volume and surface area of the bubble can be expressed by a formula.
  • the 10 micron bubble is 100 times the theoretical specific surface area of the former in a certain volume compared to a 1 mm bubble.
  • the contact area between air and water has increased by a factor of 100, and the speed of various reactions has also increased by a factor of 100.
  • the rate of rise is slow. According to Stokes' law, the rate of rise of a bubble in water is proportional to the square of the diameter of the bubble. The smaller the bubble diameter, the slower the bubble rises. From the relationship between the bubble rising speed and the bubble diameter, it can be seen that the bubble having a bubble diameter of 1 mm rises in the water at a speed of 6 m/min, and the bubble having a diameter of 10 ⁇ m rises in the water at a speed of 3 mm/min, the latter being 1/2000 of the former. . If the specific surface area is increased, the solubility of the micro-nano bubbles is 200,000 times higher than that of the general air.
  • the charge ions are rapidly concentrated and enriched at the very narrow bubble interface, which is manifested by a significant increase in the zeta potential, and a very high zeta potential value can be formed at the interface before the bubble collapses.
  • the pressure of the bubble having a diameter of 0.1 mm or more is negligibly small, and the microbubble having a diameter of 10 ⁇ m is subjected to a pressure of 0.3 atm, and the bubble having a diameter of 1 ⁇ m is subjected to a pressure of up to 3 atm.
  • the dissolution of micro-nano bubbles in water is a process in which bubbles gradually shrink.
  • the increase in pressure increases the rate of gas dissolution. With the increase of specific surface area, the speed of bubble shrinking becomes faster and faster, and finally dissolves into water. In theory, the pressure when the bubble is about to disappear is infinite.
  • a large amount of free radicals are generated: at the moment of microbubble rupture, due to the dramatic change of the disappearance of the gas-liquid interface, the accumulated high-concentration ions at the interface release the accumulated chemical energy at a time, and a large amount of hydroxyl radicals can be excited at this time.
  • Hydroxyl radicals have an ultra-high oxidation-reduction potential, and the super-oxidation produced by them can degrade pollutants such as phenol which are difficult to be oxidatively decomposed under normal conditions in water, thereby purifying the water quality.
  • Micron and nano-sized bubbles simultaneously have the effect of breaking up the polymer clusters to form small molecule groups of active water, and can ionize and decompose a small part of water molecules, which can generate active oxygen, oxygen ions, hydrogen ions and in the micro-nano bubble space.
  • Free radical ions such as hydroxide ions, especially hydroxyl radicals, have an ultra-high reduction potential, and have a super-oxidizing effect to decompose pollutants that are difficult to decompose under normal conditions in water, thereby purifying water quality.
  • the dissolution rate of micro-nano bubbles in water exceeds 85%, the dissolved oxygen concentration can reach above the saturation concentration, and the micro-nano bubbles remain in the water for a long time (upward speed 6cm/min) in the form of bubbles, which can be consumed with dissolved oxygen.
  • Continuously replenishing the active oxygen into the water provides sufficient active oxygen and strong oxidizing ion clusters for the microorganisms that treat the sewage, and ensures sufficient reaction time of the active oxygen.
  • the purification ability of the water treated by the micro-nano bubbles is far high. Self-purification ability under natural conditions.
  • the invention provides a regulation for solving the problem that the traditional gynecological lotion kills many probiotics at the same time as killing pathogenic bacteria, leading to vaginal flora imbalance and vaginal immunity, thereby causing recurrent vaginitis.
  • a gynecological vaginal lotion for regulating female vaginal micro-ecology the gynecological vaginal washing liquid for regulating female vaginal micro-ecology is added with acidic oxidation potential water volume concentration of 0.01% in acid oxidation potential water- 0.5% natural flavor, adjusted to pH 3.5-5.5 after disinfection.
  • the acidic oxidation potential water may be a mixture of nanobubble-rich hydrogen acid water and electrolytic acid water.
  • the nanobubble hydrogen-rich acidic water has a hydrogen concentration of 1-50 ppm; the redox potential OR is -400 mv-1200 mv; the nanobubble hydrogen-rich acidic water has a pH of 4.5-7.5, and the pH of the electrolytic acidic water is 2.0-4.5.
  • the acidic oxidation potential water may also be completely electrolytic acidic water having a pH of 3.8-5.5, and the composition thereof comprises an acid salt containing a mineral acid at a concentration of 0.1% to 0.5%, and an acid salt containing a mineral acid.
  • the effective chlorine concentration is ⁇ 8 ppm, and the LD50 value is more than 300 mg;
  • the acid salt refers to a salt containing a hydrogen atom which can be substituted by a metal atom, or the acid salt has a characteristic of being acidic in water, that is, a pH lower than 7.0. Acidic salt.
  • the electrolytic acidic water is a salt of a concentration of less than 0.5% added to natural water or tap water, and is prepared by electric field electrolysis.
  • the acidic oxidation potential water can also be a mixture of electrolytic acidic water and artificially ionized acidic water.
  • the artificially ionized acidic water is purified by natural water or tap water into a high-efficiency ionization tank to ionize the water, and then the positive and negative ion water is separated.
  • the acidic oxidation potential water is prepared by mixing nanobubble-rich hydrogen acid water and artificial electrolytic acid water in any ratio.
  • the acidic oxidation potential water is prepared by mixing electrolytic acidic water and artificial electrolytic acidic water in any ratio.
  • the acid salt of the inorganic acid is any one of an acid sodium salt of a mineral acid, an acid potassium salt of a mineral acid, an acid magnesium salt of a mineral acid, and an acid sulfonium salt of a mineral acid, and the pH thereof. It is 3.5-6.0.
  • the acid salt of the inorganic acid is any one of disodium dihydrogen pyrophosphate, sodium hexametaphosphate, sodium chloride, sodium dihydrogen phosphate or a mixture of any of several kinds in any ratio. .
  • the adjusted vaginal micro-ecology gynecological vaginal washing liquid has a pH of 3.8-5.0 and is specifically used for mature women.
  • the female vaginal micro-ecology gynecological vaginal lotion is applied to a pH of 4.5-5.5 and is specifically intended for girls.
  • the natural flavor is a vegetable natural flavor such as rose oil, jasmine extract, vanilla, white orchid balm, toluene resin, narcissus oil, and the like.
  • One of the preparation methods of nanobubble hydrogen-rich acidic water is as follows: (1) Degassing: vacuuming the premixed storage tank and stirring the purified water to remove the gas in the drinking water; (2) mixing the gas and water at one time: The mixed storage tank is filled with hydrogen gas and the pure water is stirred to pre-mix the hydrogen gas with the purified water to obtain a primary gas-water mixture; (3) the second gas-water mixture: the primary gas water obtained in the step (2) The mixed liquid is transported to the second-stage gas-liquid mixed chestnut, and the second-phase gas-liquid mixed chestnut is filled with hydrogen gas, so that the premixed gas water mixed liquid is further mixed with hydrogen to form a secondary gas-water mixed liquid; (4) pressurization: The secondary gas-water mixture obtained in the step (3) is injected into the pressure tank to pressurize the gas-water mixture; (5) the pressurized secondary gas-water mixture is introduced into the aeration head to generate a nano-bubble Hydrogen acid water.
  • the method for preparing electrolytic acidic water is: adding an acid salt of a mineral acid having a mass concentration of 0.1% to 1%, electrolyzing in an electrolytic cell having a separator, and selecting water concentrated in the anode of the electrolytic cell is electrolytic acidic water;
  • the pH of the acidic water is 2.0-4.0.
  • Preparation of artificially ionized acidic water Activated carbon is used as a filter layer through a water purifier, tap water is filtered, and electrolysis is performed in an electrolytic cell having a separator, and water concentrated in the anode of the electrolytic cell is selected as mixed acidic nano-ionized water.
  • the electrolysis current ranges from a few milliamperes to several amperes, with ionization electrolysis times ranging from 1 minute to 30 minutes.
  • nanobubble hydrogen-rich acidic water, electrolytic acidic water, artificial electrolytic acidic water and artificial ionized acidic water of the invention can also be directly purchased from the market.
  • the gynecological vaginal health care liquid or the medicinal gynecological lotion product prepared by the invention has the effects of treating the fungal, bacterial, trichomonas vaginitis and cervical erosion diseases of women. Because it has strong adhesion to the mucous membrane, the adhesion time is long, so that the residence time of the acidic water in the vagina is long, and the curative effect is improved. Since the pH of the gynecological lotion of the present invention ranges from 3.8 to 5.5, the irritation to the skin and mucous membranes is small.
  • a weakly acidic environment in which the female private parts maintain a pH between 4.0 and 5.5 can effectively maintain the self-cleaning function of the private parts. This pH is different for women of different ages.
  • the pH of the private shower gel for girls should be between 4.5 and 5.5, while for mature women it should be between 3.8 and 5.0.
  • the invention utilizes acidic water to adjust the pH balance, correct the flora imbalance, and hurricane insecticidal action, and has the advantages of convenient administration, good vaginal retention, no stimulation, no foreign body sensation, and no damage to the vagina.
  • the invention adopts an aqueous solution, greatly improves the bioavailability, has a good therapeutic effect on the most common bacterial vaginal diseases in gynecological reproductive tract infections, and does not pollute clothing.
  • the formula of the invention can effectively improve the vaginal cleanliness, increase the number of lactobacilli, thereby lowering the vaginal pH value, and has obvious effects in repairing vaginal micro-injury, and can be used as an auxiliary treatment after vaginitis and cervicitis treatment, and no other findings are found. Adverse events, liver and kidney function, routine examination of hematuria did not find abnormal changes, indicating that the use of the present invention is safe.
  • the invention has the advantages of screening for the pathogenesis of female vaginal micro-ecological imbalance, and promoting the inhibition of pathogenic bacteria by promoting the proliferation of lactobacilli, and the related products on the market are aimed at sterilization.
  • the result is that the balance of the normal flora is destroyed.
  • the formula of the invention increases the absolute number of dominant Lactobacillus, and the dominant Lactobacillus can be greater than 60%; at the same time, the number of pathogenic bacteria is reduced, the vaginal micro-ecological balance is maintained, the vaginal cleanliness is improved, Improve the immunity of the vaginal mucosa, so as to achieve the purpose of preventing gynecological vaginal inflammation and reducing the recurrence rate of gynecological vaginitis, and the safety is safer than other bacteriostatic agents and fungicides.
  • the invention adopts an optimized preparation process, determines a reasonable ratio of raw materials, and improves the regulation performance of the vaginal pH value.
  • the gynecological vaginal washing liquid prepared by the invention has the advantages of high transdermal absorption rate, stable quality, no side effects and reliable curative effect.
  • Scientifically prepared, the acidic oxidation potential aquatic product has a long acting time and is easily absorbed by all, so that the nano water can be diffused at a molecular level, and the bioavailability of the acidic oxidation potential water is greatly improved.
  • Fig. 1 is a schematic diagram showing the principle of the size of bubbles in a liquid
  • Fig. 2 is a schematic diagram showing the principle of charging characteristics of micro-nano bubbles
  • Fig. 3 is a schematic view showing the principle of artificially acidic water preparation
  • Fig. 4 is a schematic diagram of the principle of artificial electrolytic acid preparation and manufacturing equipment.
  • Example 1 A gynecological vaginal lotion for regulating female vaginal micro-ecology, adding nano-bubble-rich hydrogen-rich acidic water volume concentration of 0.01% natural spice rose oil to nano-bubble-rich hydrogen acid water, and adjusting pH value after disinfection is 3.5-5.5 .
  • One of the preparation methods of nanobubble hydrogen-rich acidic water is: (1) degassing: vacuuming the premixed storage tank and stirring the pure water to remove the gas in the purified water; (2) mixing the gas and water at one time: The premixed storage tank is filled with hydrogen and the pure water is stirred to premix the hydrogen with the purified water to obtain a primary gas-water mixture; (3) the second gas-water mixture: the primary gas obtained in the step (2) The water mixture is transported to the second-stage gas-liquid mixed pump, and the second gas-liquid mixed chestnut is filled with hydrogen gas, so that the pre-mixed gas water mixture is further mixed with hydrogen to form a secondary gas-water mixture; (4) supercharging : injecting the secondary gas-water mixture obtained in the step (3) into the pressure tank to pressurize the gas-water mixture; (5) passing the pressurized secondary gas-water mixture into the aeration head to generate nanobubbles Hydrogen-rich acidic water;
  • the nanobubble-rich hydrogen acid water has a hydrogen concentration of 1-50 ppm; the redox potential OR is -400 mv-1200 mv; and the nanobubble hydrogen-rich acidic water has a pH of 4.0-7.5.
  • the prepared vaginal micro-ecology gynecological vaginal lotion has a pH of 3.8-5.0, which is used for mature women.
  • the prepared female vaginal micro-ecological gynecological vaginal lotion is applied at a pH of 4.5-5.5 for use by adolescent girls.
  • the nanobubble-rich hydrogen acidic water of the present invention is water containing a large amount of nanobubble-rich hydrogen bubbles, and contains water having a higher hydrogen concentration than ordinary hydrogen water. Its hydrogen concentration is approximately 1/20 or higher of the saturation concentration.
  • the nanobubble hydrogen-rich acidic water contains a nanobubble-rich hydrogen water having a hydrogen concentration of 1 to 50 ppm and an oxidation-reduction potential OR of -400 to 1200 mv.
  • the purity of hydrogen can reach more than 99.9999%, which fully meets the safety standards of food additive hydrogen in the national standard of food safety of the People's Republic of China.
  • Example 2 A gynecological vaginal lotion for regulating female vaginal micro-ecology, a natural flavor jasmine extract of 0.05% by volume of electrolytic acidic water was added from electrolytic acidic water, and the pH was adjusted to 3.5-5.5 after disinfection.
  • the electrolytic acidic water component comprises a mineral acid-containing acid salt having a mass concentration of 0.1% to 1%, an effective chlorine concentration of the acid salt containing the inorganic acid of ⁇ 8 ppm, and an LD 50 value of more than 300 mg; the acid salt is contained A salt of a hydrogen atom which can be substituted by a metal atom, or an acid salt is an acid salt which has a property of being acidic in water, that is, a pH of less than 7.0.
  • the acid salt of the inorganic acid is any one of an acid sodium salt of a mineral acid, an acid potassium salt of a mineral acid, an acid magnesium salt of a mineral acid, and an acid sulfonium salt of a mineral acid, and the pH thereof. It is 3.5-6.0.
  • the acid salt of the inorganic acid is preferably any one or a mixture of any of disodium dihydrogen pyrophosphate, sodium hexametaphosphate, sodium chloride, and sodium dihydrogen phosphate in any ratio. a mixture of.
  • the adjusted vaginal micro-ecology gynecological vaginal washing liquid has a pH of 3.8-5.0 and is used for mature women.
  • the adjusted vaginal micro-ecology gynecological vaginal lotion is applied to a pH of 4.5-5.5 for use by adolescent girls.
  • Example 3 A gynecological vaginal lotion for regulating vaginal micro-ecology of a female, artificially acidic water was added to a natural scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented scented sap
  • the artificially-electrolyzed acidic water is prepared by adding electric field electrolysis to a natural water or tap water by adding a salt having a concentration of less than 0.2% such as sodium chloride.
  • Example 4 A gynecological vaginal lotion for regulating female vaginal micro-ecology, artificially ionized acidic water was added to a natural perfumed white scent of 0.1% by volume of artificially ionized acidic water, and the pH was adjusted to 3.7 after disinfection.
  • the artificially ionized acidic water is purified by natural water or tap water into a high-efficiency ionization tank to ionize the water, and then the positive and negative ion water is separated.
  • the activated carbon is used as a filter layer through the water purifier, the tap water is filtered, and then electrolysis is performed in an electrolytic cell having a diaphragm, and the water concentrated in the anode of the electrolytic cell is artificially ionized acidic water.
  • Example 5 A gynecological vaginal lotion for regulating female vaginal micro-ecology, which is prepared by mixing nano-foam-rich hydrogen acid water and artificial electrolytic acid water in an arbitrary ratio, the nano-bubble hydrogen-rich acidic water and artificial Electrolyzed acidic water is commercially available; the natural flavor of toluene resin with a volume concentration of 0.5% acidic water is added to adjust the pH to 3.8-5.0 for mature women; pH is 4.5-5.5 for girls.
  • Example 6 A gynecological vaginal lotion for regulating female vaginal micro-ecology, which is prepared by mixing electrolytic acid water and artificially ionized acidic water in any ratio, and the electrolytic acidic water and artificial ionized acidic water are on the market. Purchased; then add natural flavor narcissus net oil with an acid water volume concentration of 0.3%, adjust the pH value of 3.8-5.0, for mature women; pH value of 4.5-5.5, for girls.
  • FIG. 5 are schematic diagrams showing the principle of preparation of artificial electrolytic acidic water used in the present invention.
  • titanium white gold (platinum) material or other alloy material is used as the electrode plate of the electrolytic cell, and the dialysis and separation of the ceramic ion separation membrane are arranged therebetween.
  • Electrolytic alkaline and acidic water are used. They are all ionized by natural water or tap water plus an electric field. The pH value is determined by the magnitude of the applied electric field and current, the time and flow rate, and the amount of additives added. The water is filtered through a pre-filter.
  • the artificial ionized acidic water preparation machine uses tap water as a water source to filter water through a pre-filter; then the purified water is introduced into the electrolytic cell, and a DC voltage is applied to the water by using a separation membrane as a medium, and the water is decomposed by the electrolytic plate.
  • An electrical appliance that separates alkaline water from acidic water.
  • the electrolytic cell the electrolytic cell is divided into two chambers, an cation membrane, and an ionic membrane, and only ions can be freely penetrated between the two chambers.
  • the electrolysis current ranges from a few milliamperes to several amperes, with ionization electrolysis times ranging from 1 minute to 30 minutes.

Abstract

一种调节女性阴道微生态的妇科阴道洗液及其制备方法。在酸性水中加入酸性水体积浓度0. 0l%-0. 5%的天然香料，消毒后调节pH值为3. 5-5. 5制备而成。

Description

一种调节女性阴道微生态的妇科阴道洗液及其制备方法 技术领域
本发明属于保健及医疗技术领域，具体涉及一种用于调节女性阴道微生态的妇科阴道洗液及其制备方法。
背景技术
众所周知，女性下生殖道为开放性腔道，是人体内重要的微生态区，正常情况下是以优势菌为主组成的微生态系统。而女性阴道微生态失衡是引起妇科外阴及阴道炎症反复发作的主要原因。在维持阴道微生态平衡的因素中，雌激素、乳酸杆菌及阴道酸碱度(PH)起着至关重要的作用。在正常的生理情况下，雌激素使阴道上皮增生变厚并富含糖原，增加对病原体的抵抗力；糖原在阴道乳酸杆菌作用下分解为乳酸，维持阴道正常的酸性环境(pH～4.5，多在3.8～4.4)，抑制其他寄生菌及其病原体的生长，这是阴道的自净作用。
阴道内正常菌群是阴道微生态研究的核心内容，早在1892年Dederlein首次发表了关于人类阴道微生态菌群的研究。后来人们发现健康女性的阴道菌群由多种厌氧菌和需氧菌构成。目前，阴道分泌物中已分离到29种之多的微生物，其中最重要的是乳酸杆菌，它在健康女性的阴道排出物标本中分离率高达50％～80％。它能产生一些抗微生物的物质，包括乳酸、细菌素、乳酸素B和过氧化氢。产过氧化氢的乳酸杆菌在控制阴道微生态环境中起重要作用，并通过与其他过氧化物的联合作用抑制其他病原体过度生长。
正常生育年龄的妇女，体内存在足量的雌激素，和阴道里占主导地位的乳酸杆菌一起，使阴道处于一种酸性的环境(PH值大约3.8-4.5.正常情况下，阴道上皮细胞随月经周期中雌、孕激素的作用，发生周期性变化，特别是表层细胞，细胞内富含糖原，糖原分泌后，经寄生于阴道内的阴道杆菌的作用将其分解为乳酸，使阴道内保持PH为4.5的酸性环境，从而抑制致病菌的繁殖，故正常阴道液有自净或灭菌作用。
当生殖道有炎症或PH值上升时，阴道内环境即发生改变，出现大量杂菌和白细胞。根据阴道液中阴道杆菌的存在与否，以及杂菌和白细胞的多少，对阴道液的清洁程度进行分度称为阴道清洁度。意见建议：阴道分泌物的正常PH值为3.8，当pH3.8～4.2时，有利于共栖菌的繁殖，尤其是乳酸杆菌，这是健康阴道中的主要菌种，阴道液中的密度可达105～108ml，当阴道被微生物感染后，假使乳酸杆菌占优势，仍能维持pH3.8～4.2，则不会致 病，而且乳酸杆菌还能产生H 2O 2，对其他微生物有毒性作用而抑制其繁殖。
其他如乳链球菌、肠杆菌、变形杆菌、加夫基球菌、韦永球菌等在阴道下端常见，平时不产生症状。阴道菌群之间彼此制约，使病理细菌不能有所作用，假使这种平衡被破坏，互相制约作用消失，所以氢离子浓度下降，乳酸杆菌失去优势，病理菌得以繁殖，就产生症状。细菌性阴道病是由于阴道内乳酸杆菌减少而其他细菌大量繁殖，主要有加特纳氏菌、各种厌氧菌及支原体引起的混合感染。
另一方面，乳酸杆菌造成的酸性环境又有利于减少细胞表面负电荷和去除覆盖于受体表面的糖基，暴露受体而有助于细菌黏附。因此乳酸杆菌是通过正反两方面调节正常阴道的菌群。阴道微生态平衡一旦被打破或外源病原体侵入，即可导致炎症发生，如雌激素水平改变或阴道PH升高；滥用或使用抗生素会使病菌产生耐药性，并杀死大量有益菌，破坏阴道菌群的平衡，从而导致真菌生长旺盛，妇科疾病顽固难缠，难以彻底根治。
比如说滴虫性阴道炎，它是由阴道毛滴虫所致，而这种引起滴虫性阴道炎的病原体适宜的环境是PH值在5.2～6.6之间，因此临床常可见许多得这种妇科疾病的女性，总因为该病在在月经后复发而困扰不已。
由此可见，阴道PH值是十分重要的，这将有利于对妇科疾病的预防，同时阴道PH值呈现弱酸性也告诉大家这么一个道理，用碱性物质洗阴道往往会破坏阴道的弱酸性环境，而有利于细菌繁殖。阴道的PH值是酸性的。正常人的阴道PH值≤4.5，多在3.8-4.4。患有阴道炎症时阴道PH值会变化，其值的变化与引起炎症的病原体密切相关，病原体不同，炎症轻重的程度不同，其PH值也相应不同。
在月经后以及性生活后，阴道PH值会偏离正常范围，而有利于细菌繁殖。
综上所述，改善阴道微环境，修复阴道微损伤，维持阴道微生态平衡、改善阴道清洁度、提高阴道粘膜免疫力，对于治疗女性阴道常见疾病具有重要意义，同时要考虑避免使用抗生素所引发的耐药性、二重感染、过敏反应以及对机体的毒副作用等弊端。目前市场上出现的妇科凝胶多为中药成分，且主要是通过抑制有害病菌来达到治疗妇科病的目的，在杀灭致病菌的同时也杀灭了很多益生菌，导致阴道内菌群失调、阴道免疫力低下，从而致使阴道炎反复发作，无法根治。
因此如何能够提供一种合理的辅助治疗手段，能够同时持久保健和维持女性阴道的微生态平衡，从而达到预防和治疗女性阴道微生态失衡的目的，是摆在广大科研和医务工作者面前的重要难题。
电解功能水是在特殊装置中将电解质稀溶液经电场处理，使水的pH、氧化还原电位(ORP)、有效氯浓度(ACC)等指标发生改变而产生的具有特殊功能的酸性水和碱性水的总称。按其理化性质可以分为电解强酸性功能水、电解微酸性功能水、电解弱碱性功能水和电解碱性离子水。
酸性氧化电位水是各类人工电解强性功能水的总称，它包括电解强酸性水，电解弱酸性水，电离酸性水与人工富氢纳米泡酸性水。人工电解强酸性水的pH通常在2.0～3.5之间，具有较高氧化还原电位值，一般达1000～1200mV，有效氯浓度为20～200mg/L。人工电解酸性水(包括强酸性水和微酸性水)具有消毒杀菌功能，主要用于果蔬保鲜、芽苗菜的生产、鲜切花的保鲜、设备的消毒、毒素的降解、畜产养殖及植物保护等领域。人工电解酸性水的杀菌机理主要有自由基学说、有效氯学说、氧化还原电位的强氧化学说等。
人工电解弱酸性水的pH通常在3.5～6.0之间.一般來说人工电解酸性水的定义为：添加微量氯化钠(NaCl浓度0.2％以下)的水，在有隔膜的电解槽中电解，从阳极得到的以次氯酸(HClO)为主要有效成分的酸性水溶液。人工弱电解酸性水大都应用在饮用、食物清洗浸泡及与人体或动物接触之消毒等，人工强电解酸性水则在工业及医界之器材消毒、清洗较多。业界认为人工电解酸性水中有一定浓度的次氯酸(HOCl或HClO)而导致溶液pH下降，次氯酸中OCl-根产生杀菌效果。
所谓电离水,即通过整水器利用活性炭作为过滤层,过滤自来水,使之净化达标(达到国家级水标准),再通过膈膜电解生成两种活性的水,即离子水.集中于阴极流出来的为电离碱性离子水；集中于阳极流出来的为电离酸性离子水。
离子水其本质是水，除了电子得失外不添加任何物质。离子水在使用过程中会因与空气或其他物质接触逐渐(还原)成为普通水。离子水是通过电离产生的，其过程为普通自来水经过净化进入高效电离槽，使水产生电离，并通过高科技手段将正负离子水分离。离子水和普通水相比其渗透压(强弱)、分子团(大小)，溶解度(大小)电导率(高低)、PH值(大小)、表面张力、密度、热导率、含氧量等都不尽相同。因此离子水的活性比普通水(含矿泉水、纯净水)强的多。
通常认为电离酸性离子水含有氢离子(H4O9+)而生成低pH值的酸性水，也称为氧化水.离子水的独特的医疗保健，美容消炎、杀菌作用是普通水所没有的。离子水在工农业上的应用目前还在不断的开拓中。
纳米泡富氢酸性水是含有大量纳米泡富氢气泡的水，比普通的氢气水含有更高氢气浓度 的水。其含氢浓度大约为饱和浓度的1/20或更高。
通常我们把气体在液体中的存在现象称作气泡。气泡的形成现象，在自然界中的许多过程中都能遇到，当气体在液体中受到剪切力的作用时就会形成大小、形状各不相同的气泡。目前，对气泡的分类与定义并不是十分严格，按照从大到小的顺序可分为厘米气泡(CMB)、毫米气泡(MMB)、微米气泡(MB)、微纳米气泡(MNB)、纳米气泡(NB)。所谓的微纳米气泡，是指气泡发生时直径在10微米左右到数百纳米之间的气泡，这种气泡是介于微米气泡和纳米气泡之间，具有常规气泡所不具备的物理与化学特性。
微纳米气泡的特性：1.比表面积大。气泡的体积和表面积的关系可以通过公式表示。气泡的体积公式为V＝4π/3r3，气泡的表面积公式为A＝4πr2，两公式合并可得A＝3V/r，即V总＝n·A＝3V总/r。也就是说，在总体积不变(V不变)的情况下，气泡总的表面积与单个气泡的直径成反比。根据公式，10微米的气泡与1毫米的气泡相比较，在一定体积下前者的比表面积理论上是后者的100倍。空气和水的接触面积就增加了100倍，各种反应速度也增加了100倍。
2.上升速度慢。根据斯托克斯定律，气泡在水中的上升速度与气泡直径的平方成正比。气泡直径越小则气泡的上升速度越慢。从气泡上升速度与气泡直径的关系图可知，气泡直径1mm的气泡在水中上升的速度为6m/min，而直径10μm的气泡在水中的上升速度为3mm/min，后者是前者的1/2000。如果考虑到比表面积的增加，微纳米气泡的溶解能力比一般空气增加20万倍。
3.表面带电：纯水溶液是由水分子以及少量电离生成的H+和OH-组成，气泡在水中形成的气液界面具有容易接受H+和OH-的特点，而且通常阳离子比阴离子更容易离开气液界面，而使界面常带有负电荷。已经带上电荷的表面一般倾向于吸附介质中的反离子，特别是高价的反离子，从而形成稳定的双电层。微气泡的表面电荷产生的电势差常利用ζ电位来表征，ζ电位是决定气泡界面吸附性能的重要因素。当微纳米气泡在水中收缩时，电荷离子在非常狭小的气泡界面上得到了快速浓缩富集，表现为ζ电位的显著增加，到气泡破裂前在界面处可形成非常高的ζ电位值。
4.自身增压溶解：水中的气泡四周存有气液界面，而气液界面的存在使得气泡会受到水的表面张力的作用。对于具有球形界面的气泡，表面张力能压缩气泡内的气体，从而使更多的气泡内的气体溶解到水中。根据杨-拉普拉斯方程，ΔP＝2σ/r,ΔP代表压力上升的数值，σ代表表面张力，r代表气泡半径。直径在0.1mm以上的气泡所受压力很小可以忽略，而直 径10μm的微小气泡会受到0.3个大气压的压力，而直径1μm的气泡会受高达3个大气压的压力。微纳米气泡在水中的溶解是一个气泡逐渐缩小的过程，压力的上升会增加气体的溶解速度，伴随着比表面积的增加，气泡缩小的速度会变的越来越快，从而最终溶解到水中，理论上气泡即将消失时的所受压力为无限大。
5.产生大量自由基：微气泡破裂瞬间，由于气液界面消失的剧烈变化，界面上集聚的高浓度离子将积蓄的化学能一下子释放出来，此时可激发产生大量的羟基自由基。羟基自由基具有超高的氧化还原电位，其产生的超强氧化作用可降解水中正常条件下难以氧化分解的污染物如苯酚等，实现对水质的净化作用。
微米、纳米级气泡的同时具有打碎聚合分子团，形成小分子团活性水的效果，并能够将小部分水分子电离分解，可以在微纳米气泡空间中产生活性氧、氧离子、氢离子和氢氧离子等自由基离子，尤其氢氧自由基有超高的还原电位，具有超强氧化效果可以分解水中正常条件下也难以分解的污染物，实现水质的净化。微纳米气泡在水中的溶解率超过85％，溶解氧浓度可以达到饱和浓度以上，并且微纳米气泡是以气泡的方式长时间(上升速度6cm/分钟)存留在水中，可以随着溶解氧的消耗不断地向水中补充活性氧，为处理污水的微生物提供了充足的活性氧、强氧化性离子团，并保证了活性氧充足的反应时间，由微纳米气泡处理过的水的净化能力远远高于自然条件下的自净能力。
发明内容
本发明为了解决传统妇科洗液在杀灭致病菌的同时也杀灭了很多益生菌，导致阴道内菌群失调、阴道免疫力低下，从而致使阴道炎反复发作的问题，提供了一种调节女性阴道微生态的妇科阴道洗液及其制备方法。
本发明是采用如下技术方案实现的：一种调节女性阴道微生态的妇科阴道洗液，所述调节女性阴道微生态的妇科阴道洗液为酸性氧化电位水中加入酸性氧化电位水体积浓度0.01％-0.5％的天然香料，消毒后调节pH值为3.5-5.5。
所述酸性氧化电位水可以是纳米泡富氢酸性水与电解酸性水的混合。其纳米泡富氢酸性水含氢浓度为1-50ppm；氧化还原电位OR为-400mv-1200mv；所述纳米泡富氢酸性水的pH值为4.5-7.5，所述电解酸性水的pH值为2.0-4.5。
所述的酸性氧化电位水也可以完全是pH值为3.8-5.5的电解酸性水，其成分包含质量浓度为0.1％-0.5％的含有无机酸的酸式盐，含有无机酸的酸式盐中有效氯浓度为≥8ppm，LD5tl值大于300mg；所述酸式盐指含有能够被金属原子取代的氢原子的盐，或者酸式盐为 具有溶解在水中显示出酸性的特性即pH值低于7.0的酸式盐。
所述电解酸性水为天然水或自来水添加浓度低于0.5％的盐，采用电场电解制备而成。
所述酸性氧化电位水也可以电解酸性水与人工电离酸性水的混合。人工电离酸性水为天然水或自来水经过净化进入高效电离槽，使水电离，然后将正负离子水分离。
所述酸性氧化电位水为纳米泡富氢酸性水和人工电解酸性水以任意比例混合制备而成。
所述酸性氧化电位水为电解酸性水和人工电解酸性水以任意比例混合制备而成。
所述的无机酸的酸式盐为无机酸的酸式钠盐、无机酸的酸式钾盐、无机酸的酸式镁盐、无机酸的酸式钡盐中的任意一种，其pH值为3.5-6.0。
进一步优选：所述的无机酸的酸式盐为焦磷酸二氢二钠、六偏磷酸钠、氯化钠、磷酸二氢钠中的任意一种或任意几种以任意比例混合而成的混合物。
所述调节女性阴道微生态妇科阴道洗液pH值为3.8-5.0，专门针对成熟女性使用。
所述调节女性阴道微生态妇科阴道洗液应用于的pH值为4.5-5.5，专门针对少女使用。
所述天然香料为植物性天然香料，如玫瑰油、茉莉浸膏、香荚兰酊、白兰香脂、吐鲁香树脂、水仙净油等。
纳米泡富氢酸性水制备方法之一为：(1)除气：将预混储水罐抽真空并对纯净水进行搅拌，去除饮用水内的气体；(2)一次气水混合：向预混储水罐内充入氢气并对纯净水进行搅拌，使氢气与纯净水进行预混，得到一次气水混合液；(3)二次气水混合：将步骤(2)得到的一次气水混合液输送至二级气液混合栗，并向二级气液混合栗内充入氢气，使预混气水混合液进一步与氢气混合，形成二次气水混合液；(4)增压：将步骤(3)得到的二次气水混合液注入压力罐，对气水混合液进行增压；(5)将增压后的二次气水混合液通入曝气头，产生纳米泡富氢酸性水。
电解酸性水制备方法为：添加质量浓度为0.1％-1％的无机酸的酸式盐，在有隔膜的电解槽中电解，选取集中于电解槽阳极的水即为电解酸性水；所述电解酸性水的pH值为2.0-4.0。
人工电离酸性水制备：通过整水器利用活性炭作为过滤层，过滤自来水，再通过有隔膜的电解槽中电解，选取集中于电解槽阳极的水即为混合酸性纳米离子水。根据工业化或家庭电解设备的大小设计，电解电流的大小从几毫安到几安培不等，电离电解时间从1分钟到30分钟不等。
本发明所述纳米泡富氢酸性水、电解酸性水、人工电解酸性水、人工电离酸性水也可以直接从市场购买。
本发明制备的妇科阴道保健液或药用妇科洗液产品有治疗妇女霉菌性、细菌性、滴虫性阴道炎、宫颈糜烂病症的功效。由于它具有与粘膜有较强的粘附能力，因而粘附时间长，使酸性水在阴道内的滞留时间长，提高了疗效。由于本发明的妇科洗液的PH值范围为3.8-5.5，对皮肤粘膜的刺激很小。
女性私处pH值维持在4.0-5.5之间的弱酸性的环境能够有效维护私处的自洁功能。这个pH值对不同年龄的女性还不同，针对少女的私处沐浴露pH应该在4.5-5.5之间，而成熟女性则需要在3.8-5.0之间。
本发明利用酸性水具有调节酸碱度平衡、纠正菌群失调、祛风杀虫的作用，具有给药方便、阴道内滞留性好、无刺激、无异物感、不损伤阴道的优点。本发明采用水溶液，大大提高了生物利用度，对妇科生殖道感染中最常见的细菌性阴道病，具有良好的治疗效果，并不污染衣物。
本发明所述的配方可以有效改善阴道清洁度，提高乳酸杆菌数量，进而降低阴道PH值，在修复阴道微损伤方面效果明显，可作为阴道炎、宫颈炎治疗后的辅助治疗，另外未发现任何不良事件，进行肝肾功能、血尿常规检查未发现异常改变，说明本发明使用是安全的。
与现有技术相比，本发明的优势在于针对女性阴道微生态失衡的发病机理来筛选，通过促进乳杆菌增殖而达到抑制致病菌的目的，而目前市场上相关产品均以杀菌为目的，其结果破坏了正常菌群的平衡，本发明配方增加了优势菌乳杆菌的绝对数，使优势乳杆菌能够大于60％；同时降低致病菌数目，维持阴道微生态平衡、改善阴道清洁度、提高阴道粘膜免疫力，从而达到预防妇科阴道炎症、降低妇科阴道炎复发率的目的，且安全性相比较，较其它抑菌剂、杀菌剂更安全。
本发明釆用经过优化的制备工艺，确定原料的合理配比，提高了阴道pH值的调节性能。采用本发明制成的调节女性阴道微生态的妇科阴道洗液透皮吸收率高，质量稳定，无副作用，疗效可靠。经科学制备，酸性氧化电位水产品作用时间较长、容易被全部吸收，可使纳米水呈分子水平扩散，大大提高了酸性氧化电位水的生物利用度。
附图说明
图1为液体中气泡的尺寸原理示意图；图2为微纳米气泡表面带电特性原理示意图；图 3为人工电解酸性水制备原理示意图；图4为人工电解酸性水制备制造设备原理示意图。
具体实施方式
实施例1：一种调节女性阴道微生态的妇科阴道洗液，为纳米泡富氢酸性水中加入纳米泡富氢酸性水体积浓度0.01％的天然香料玫瑰油，消毒后调节pH值为3.5-5.5。
纳米泡富氢酸性水的制备方法之一为：(1)除气：将预混储水罐抽真空并对纯净水进行搅拌，去除纯净水内的气体；(2)一次气水混合：向预混储水罐内充入氢气并对纯净水进行搅拌，使氢气与纯净水进行预混，得到一次气水混合液；(3)二次气水混合：将步骤(2)得到的一次气水混合液输送至二级气液混合栗，并向二级气液混合栗内充入氢气，使预混气水混合液进一步与氢气混合，形成二次气水混合液；(4)增压：将步骤(3)得到的二次气水混合液注入压力罐，对气水混合液进行增压；(5)将增压后的二次气水混合液通入曝气头，产生纳米泡富氢酸性水；
所述纳米泡富氢酸性水中含氢浓度为1-50ppm；氧化还原电位OR为-400mv-1200mv；所述纳米泡富氢酸性水的pH值为4.0-7.5。所制备的调节女性阴道微生态妇科阴道洗液pH值为3.8-5.0，针对成熟女性使用。所制备的调节女性阴道微生态妇科阴道洗液应用于的pH值为4.5-5.5，针对少女使用。
本发明的所述的纳米泡富氢酸性水是含有大量纳米泡富氢气泡的水，比普通的氢气水含有更高氢气浓度的水。其含氢浓度大约为饱和浓度的1/20或更高。
所述的纳米泡富氢酸性水含有纳米泡富氢水中氢气浓度为1～50ppm，氧化还原电位OR为-400～1200mv。其中氢气纯度能够达到99.9999％以上，完全符合中华人民共和国国家标准食品安全国家标准食品添加剂氢气的安全标准。
实施例2：一种调节女性阴道微生态的妇科阴道洗液，由电解酸性水加入电解酸性水体积浓度0.05％的天然香料茉莉浸膏，消毒后调节pH值为3.5-5.5。
电解酸性水其成分包含质量浓度为0.1％-1％的含有无机酸的酸式盐，含有无机酸的酸式盐中有效氯浓度为≥8ppm，LD5tl值大于300mg；所述酸式盐指含有能够被金属原子取代的氢原子的盐，或者酸式盐为具有溶解在水中显示出酸性的特性即pH值低于7.0的酸式盐。
所述的无机酸的酸式盐为无机酸的酸式钠盐、无机酸的酸式钾盐、无机酸的酸式镁盐、无机酸的酸式钡盐中的任意一种，其pH值为3.5-6.0。
进一步从安全性优异的观点出发优选，无机酸的酸式盐为焦磷酸二氢二钠、六偏磷酸钠、氯化钠、磷酸二氢钠中的任意一种或任意几种以任意比例混合而成的混合物。
所述调节女性阴道微生态妇科阴道洗液pH值为3.8-5.0，针对成熟女性使用。
所述调节女性阴道微生态妇科阴道洗液应用于的pH值为4.5-5.5，针对少女使用。
实施例3：一种调节女性阴道微生态的妇科阴道洗液，由人工电解酸性水加入人工电解酸性水体积浓度0.04％的天然香料香荚兰酊，消毒后调节pH值为3.5。
人工电解酸性水为天然水或自来水添加浓度低于0.2％的盐如氯化钠，采用电场电解制备而成。
实施例4：一种调节女性阴道微生态的妇科阴道洗液，由人工电离酸性水加入人工电离酸性水体积浓度0.1％的天然香料白兰香脂，消毒后调节pH值为3.7。
人工电离酸性水为天然水或自来水经过净化进入高效电离槽，使水电离，然后将正负离子水分离。通过整水器利用活性炭作为过滤层，过滤自来水，再通过有隔膜的电解槽中电解，选取集中于电解槽阳极的水即为人工电离酸性水。
实施例5：一种调节女性阴道微生态的妇科阴道洗液，由纳米泡富氢酸性水和人工电解酸性水以任意比例混合制备而成的酸性水，所述纳米泡富氢酸性水和人工电解酸性水为市场上购得；加入酸性水体积浓度0.5％的天然香料吐鲁香树脂，调节pH值为3.8-5.0，针对成熟女性使用；pH值为4.5-5.5，针对少女使用。
实施例6：一种调节女性阴道微生态的妇科阴道洗液，由电解酸性水和人工电离酸性水以任意比例混合制备而成的酸性水，所述电解酸性水和人工电离酸性水由市场上购得；然后加入酸性水体积浓度0.3％的天然香料水仙净油，调节pH值为3.8-5.0，针对成熟女性使用；pH值为4.5-5.5，针对少女使用。
图3至图5为本发明采用的人工电解酸性水制备原理示意图。是依据“电化学”与“电解”原理，采用钛白金(铂)素材或其它合金材质，做为电解槽之电极板，其间配置陶瓷离子分离膜的透析与分离作用.电解碱性和酸性水均由天然水或自来水加电场电离而成，其pH值由制备时外加电场与电流的大小，时间与流速和添加物的添加量决定。通过前置过滤器对水进行过滤。
人工电离酸性水制备机就是将以自来水为水源，通过前置过滤器对水进行过滤；然后得到的净水进入电解槽，以分离膜为媒介在水中施以直流电压，利用电解板使水分解，既而分离出碱性水与酸性水的一种电器。在电解槽中，电解槽由离子膜分为阴、阳两室，两室之间只有离子可以自由穿透。根据工业化或家庭电解设备的大小设计，电解电流的大小从几毫安到几安培不等，电离电解时间从1分钟到30分钟不等。
上述实施例阐明了本发明的实施方式。然而需要说明的是，上面仅是用电解酸性水制备调节女性阴道微生态的妇科阴道洗液及其制备方法的工艺发明原理应用的示例或举例说明。本领域技术人员可以设计出许多改变和可选的组合物、方法和系统，而没有脱离本发明的精神和范围，例如pH值的范围在4.0-5.5或3.8-5.0之间。
因此所附权利要求意欲覆盖这些改变和安排。尽管本发明在上面进行详细举例描述，但是上面的实施例提供了是本发明实施方式的某个细节之一。在不脱离本发明的核心内容：纳米泡富氢水与电离酸性水制备的调节女性阴道微生态的妇科阴道洗液产品工艺构思的前提下，还可以做出若干许多变形和改进，这些都属于本发明的保护范围。

Claims (12)

  1. 一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述调节女性阴道微生态的妇科阴道洗液为酸性氧化电位水中加入酸性氧化电位水体积浓度0.01％-0.5％的天然香料，消毒后调节pH值为3.5-5.5。
  2. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述酸性氧化电位水为纳米泡富氢酸性水与电解酸性水的混合，所述纳米泡富氢酸性水的含氢浓度为1-50ppm；氧化还原电位OR为-400mv-1200mv；所述纳米泡富氢酸性水的pH值为4.5-7.5；所述电解酸性水的pH值为2.0-4.5。
  3. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述酸性氧化电位水为pH值为3.8-5.5的电解酸性水，其成分包含质量浓度为0.1％-0.5％的含有无机酸的酸式盐，含有无机酸的酸式盐中有效氯浓度为≥8ppm，LD5tl值大于300mg；所述酸式盐指含有能够被金属原子取代的氢原子的盐，或者酸式盐为具有溶解在水中显示出酸性的特性即pH值低于7.0的酸式盐。
  4. 根据权利要求3所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述电解酸性水为天然水或自来水添加浓度低于0.5％的盐，采用电场电解制备而成。
  5. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述酸性氧化电位水为电解酸性水与人工电离酸性水的混合，人工电离酸性水为天然水或自来水经过净化进入高效电离槽，使水电离，然后将正负离子水分离。
  6. 根据权利要求1或2所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述酸性氧化电位水为纳米泡富氢酸性水和人工电解酸性水以任意比例混合制备而成。
  7. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述酸性氧化电位水为电解酸性水和人工电解酸性水以任意比例混合制备而成。
  8. 根据权利要求3所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述的无机酸的酸式盐为无机酸的酸式钠盐、无机酸的酸式钾盐、无机酸的酸式镁盐、无机酸的酸式钡盐中的任意一种，其pH值为3.5-6.0。
  9. 根据权利要求8所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述的无机酸的酸式盐为焦磷酸二氢二钠、六偏磷酸钠、氯化钠、磷酸二氢钠中的任意一 种或任意几种以任意比例混合而成的混合物。
  10. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述调节女性阴道微生态妇科阴道洗液的pH值为3.8-5.0。
  11. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述调节女性阴道微生态妇科阴道洗液的pH值为4.5-5.5。
  12. 根据权利要求1所述的一种调节女性阴道微生态的妇科阴道洗液，其特征在于：所述天然香料为植物性天然香料。
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