WO2018135932A3 - Hmg-coa 환원효소 억제제 및 클로피도그렐을 포함하는 복합제제 - Google Patents

Hmg-coa 환원효소 억제제 및 클로피도그렐을 포함하는 복합제제 Download PDF

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Publication number
WO2018135932A3
WO2018135932A3 PCT/KR2018/001033 KR2018001033W WO2018135932A3 WO 2018135932 A3 WO2018135932 A3 WO 2018135932A3 KR 2018001033 W KR2018001033 W KR 2018001033W WO 2018135932 A3 WO2018135932 A3 WO 2018135932A3
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WIPO (PCT)
Prior art keywords
hmg
coa reductase
reductase inhibitor
clopidogrel
complex formulation
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PCT/KR2018/001033
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English (en)
French (fr)
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WO2018135932A2 (ko
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백남현
최민수
김자영
우지영
성승규
송영준
서기수
허운
정태성
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동화약품주식회사
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Priority to BR112019015107-9A priority Critical patent/BR112019015107A2/pt
Priority to EP18741071.7A priority patent/EP3572075A2/en
Priority to CN201880008094.3A priority patent/CN110198705A/zh
Priority to JP2019560617A priority patent/JP2020507621A/ja
Priority to MX2019009213A priority patent/MX2019009213A/es
Priority to US16/479,861 priority patent/US20200129440A1/en
Publication of WO2018135932A2 publication Critical patent/WO2018135932A2/ko
Publication of WO2018135932A3 publication Critical patent/WO2018135932A3/ko

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    • A—HUMAN NECESSITIES
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    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 클로피도그렐, HMG-CoA 환원효소 억제제 및 소수성 화합물을 함유한 분리막을 포함하는 복합제제에 관한 것이다. 보다 구체적으로 본 발명의 목적은 클로피도그렐과 HMG-CoA 환원효소 억제제를 포함하는 복합제제에 있어, HMG-CoA 환원효소 억제제의 안정성 저하를 막아 보관안정성이 우수한 심혈관계 질환 예방 또는 치료용 복합제제를 제공하는 것이다.
PCT/KR2018/001033 2017-01-23 2018-01-23 Hmg-coa 환원효소 억제제 및 클로피도그렐을 포함하는 복합제제 WO2018135932A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR112019015107-9A BR112019015107A2 (pt) 2017-01-23 2018-01-23 Formulação de complexo compreendendo inibidor de hmg-coa redutase e clopidogrel
EP18741071.7A EP3572075A2 (en) 2017-01-23 2018-01-23 Complex formulation comprising hmg-coa reductase inhibitor and clopidogrel
CN201880008094.3A CN110198705A (zh) 2017-01-23 2018-01-23 包含hmg-coa还原酶抑制剂和氯吡格雷的复合制剂
JP2019560617A JP2020507621A (ja) 2017-01-23 2018-01-23 ＨＭＧ−ＣｏＡ還元酵素阻害剤およびクロピドグレルを含む複合製剤
MX2019009213A MX2019009213A (es) 2017-01-23 2018-01-23 Formulación compleja que comprende inhibidor de la hmg-coa reductasa y clopidogrel.
US16/479,861 US20200129440A1 (en) 2017-01-23 2018-01-23 Complex formulation comprising hmg-coa reductase inhibitor and clopidogrel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0010532 2017-01-23
KR20170010532 2017-01-23

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WO2018135932A2 WO2018135932A2 (ko) 2018-07-26
WO2018135932A3 true WO2018135932A3 (ko) 2018-09-27

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PCT/KR2018/001033 WO2018135932A2 (ko) 2017-01-23 2018-01-23 Hmg-coa 환원효소 억제제 및 클로피도그렐을 포함하는 복합제제

Country Status (8)

Country Link
US (1) US20200129440A1 (ko)
EP (1) EP3572075A2 (ko)
JP (1) JP2020507621A (ko)
KR (1) KR102139346B1 (ko)
CN (1) CN110198705A (ko)
BR (1) BR112019015107A2 (ko)
MX (1) MX2019009213A (ko)
WO (1) WO2018135932A2 (ko)

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JP2002506809A (ja) * 1998-03-18 2002-03-05 ブリストル−マイヤーズ スクイブ カンパニー スタチンおよびアスピリン含有医薬組成物
KR20090017423A (ko) * 2007-08-13 2009-02-18 한올제약주식회사 ＨＭＧ­ＣｏＡ 환원효소 저해제와 아스피린을 포함하는 복합제제 및 그의 제조방법
KR20110090060A (ko) * 2010-02-02 2011-08-10 한미홀딩스 주식회사 소수성 첨가제가 함유된 분리막으로 코팅된 아스피린 및 ＨＭＧ―ＣｏＡ 환원효소 억제제를 포함하는 복합제제
CN101985041A (zh) * 2010-11-08 2011-03-16 北京阜康仁生物制药科技有限公司 含有氯吡格雷和他汀类化合物的药物组合物

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Publication number Publication date
BR112019015107A2 (pt) 2020-03-10
EP3572075A2 (en) 2019-11-27
MX2019009213A (es) 2019-09-27
WO2018135932A2 (ko) 2018-07-26
JP2020507621A (ja) 2020-03-12
KR20180087190A (ko) 2018-08-01
US20200129440A1 (en) 2020-04-30
CN110198705A (zh) 2019-09-03
KR102139346B1 (ko) 2020-07-29

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