WO2018120113A1 - 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法 - Google Patents

一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法 Download PDF

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Publication number
WO2018120113A1
WO2018120113A1 PCT/CN2016/113717 CN2016113717W WO2018120113A1 WO 2018120113 A1 WO2018120113 A1 WO 2018120113A1 CN 2016113717 W CN2016113717 W CN 2016113717W WO 2018120113 A1 WO2018120113 A1 WO 2018120113A1
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WIPO (PCT)
Prior art keywords
dental implant
alveolar bone
mussel mucin
implant
treatment
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PCT/CN2016/113717
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English (en)
French (fr)
Inventor
张�杰
许钦
严一红
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江阴金泰克生物技术有限公司
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Application filed by 江阴金泰克生物技术有限公司 filed Critical 江阴金泰克生物技术有限公司
Priority to PCT/CN2016/113717 priority Critical patent/WO2018120113A1/zh
Publication of WO2018120113A1 publication Critical patent/WO2018120113A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools

Definitions

  • Dental implant treatment method for rapidly promoting dental implant and alveolar bone
  • the invention relates to a method for preparing a medical device, in particular to a method for treating a surface of an implant which can quickly promote the combination of a dental implant and an alveolar bone.
  • the original dental implants were mainly mechanically processed, that is, directly made of pure titanium as raw materials, and directly processed into implants according to mechanical design drawings.
  • the doctor removed the roots of the patients with missing teeth and repaired the alveolar bone wounds for 3-6 months.
  • Implantation of implants is very time consuming and inconvenient for patients with missing teeth.
  • researchers began a large number of studies on implant surface treatment.
  • HA hydroxyapatite
  • the disadvantage of this method is that the HA coating peels off when the implant is implanted, and the effect is poor.
  • a third representative surface treatment implant has emerged, which is also the most widely used surface treatment method in the domestic and international markets, such as sandblasting acid etching (SLA), including the fourth generation implant titanium that is currently being developed.
  • SLA sandblasting acid etching
  • Ease, etc. almost all of these studies on implants are based on implant surface treatment to increase the success rate of immediate planting, but these surface treatment techniques still require the combination of post-emergence and alveolar bone. A few months of dental implants are combined with alveolar bone.
  • the technical problem to be solved by the present invention is to overcome the defects that the existing dental implant processing technology makes the dental implant and the alveolar bone relatively slow, and provide a dental implant processing method for rapidly promoting the combination of the dental implant and the alveolar bone. .
  • the present invention provides the following technical solutions:
  • a dental implant treatment method for rapidly promoting dental implant and alveolar bone comprising the following steps:
  • the dental implant is machined by using pure titanium material
  • the dental implant is subjected to sandblasting acid etching (SLA) treatment;
  • the dental implant is soaked in the mussel mucin solution. Further, the mussel mucin concentration is 10 to 200 mg/L, and the soaking time is 0.5 to 2 h.
  • Mussel mucin is a kind of protein with special viscosity secreted by marine mussels. It has high strength, high toughness, strong acid resistance, strong alkali resistance, good biocompatibility, no toxic side effects, no immune reaction.
  • the advantage of degradation, and the mussel mucin is a basic protein, and the surface of the molecule is positively charged under the physiological environment of the human body, and the negatively charged cells are easily adsorbed.
  • the present invention adopts the method of surface treatment of the dental implant by mussel mucin for the first time.
  • the dental implant treated by the present invention has no side effects, and can quickly promote the combination of the implant and the alveolar bone.
  • a dental implant treatment method for rapidly promoting dental implant and alveolar bone comprising the following steps:
  • the dental implant is machined by using pure titanium material
  • the dental implant is subjected to sandblasting acid etching (SLA) treatment;
  • the dental implant was immersed in a mussel mucin solution at a concentration of 10 mg/L for 2 hours.
  • a dental implant treatment method for rapidly promoting dental implant and alveolar bone comprising the following steps:
  • the dental implant is machined by using pure titanium material
  • the dental implant is subjected to sandblasting acid etching (SLA) treatment;
  • the dental implant was immersed in a mussel mucin solution having a concentration of 200 mg/L for 0.5 h.
  • a dental implant treatment method for rapidly promoting dental implant and alveolar bone comprising the following steps:
  • the dental implant is machined by using pure titanium material
  • the dental implant is subjected to sandblasting acid etching (SLA) treatment;
  • the dental implant was immersed in a mussel mucin solution at a concentration of 100 mg/L for 1 h.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)

Abstract

一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，包括以下步骤：1)、采用纯钛材料机械加工制备牙种植体；2)、将牙种植体进行喷砂酸蚀(SLA)处理；3)、将牙种植体在贻贝粘蛋白溶液中浸泡处理。贻贝粘蛋白是由海洋贻贝分泌的具有特殊粘性的一种蛋白，它具有高强度、高韧性、耐强酸、耐强碱、生物相容性好、无毒副作用、不发生免疫反应、可降解的优点，而且贻贝粘蛋白为碱性蛋白，在人体生理环境下分子表面带正电荷，容易吸附带负电的细胞，采用贻贝粘蛋白对牙种植体进行表面处理，对牙种植体无副作用，用能快速促进种植体与牙槽骨的结合。

Description

一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法
技术领域
本发明涉及医用器材制备方法，特别涉及一种能快速促进牙种植体与牙槽骨结合的种植体表面处理方法。
背景技术
80 年代初，随着瑞典Branemark系统钛骨愈合理论，钛与骨直接结合并能支持咬合力的原理，完成良好的假牙修复。被广泛接受，牙种植技术走向成熟，目前种植牙是一种成熟的临床修复技术。
最初的牙种植体以单纯的机械加工为主，即直接以纯钛为原材料，按照机械设计图直接加工成种植体，医生将缺牙患者的牙根拔除，3～6个月待牙槽骨创伤修复后再植入种植体，非常耗时，也给缺牙患者带来不便。为了促进种植体与牙槽骨的结合，实现种植体的即刻种植，研究人员开始在种植体表面处理方面进行大量研究，首先就出现了第二代表面处理种植体如羟基磷灰石（HA）表面涂层的种植体，这种方法的缺点在于种植体植入时会发生HA涂层脱落的现象，效果欠佳。随之又出现了第三代表面处理种植体，也是目前国内外市场上使用得最广泛的一种表面处理方式，如喷砂酸蚀（SLA），包括现在正在研发的第四代种植体钛易耐等等，几乎绝大部分关于种植体的这些研究都是围绕种植体表面处理以增加即刻种植的成功率来进行，但是这些表面处理技术仍然处理后植体与牙槽骨的结合仍然需要几个月的牙种植体与牙槽骨结合。
发明内容
本发明要解决的技术问题是克服现有的牙种植体处理技术使得牙种植体与牙槽骨结合较为缓慢的缺陷，提供一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法 。
为了解决上述技术问题，本发明提供了如下的技术方案：
一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，包括以下步骤:
1 ）、采用纯钛材料机械加工制备牙种植体；
2 ）、将牙种植体进行喷砂酸蚀（SLA）处理；
3 ）、将牙种植体在贻贝粘蛋白溶液中浸泡处理。进一步的，贻贝粘蛋白的浓度为10～200mg/L，浸泡时间为0.5～2h。
贻贝粘蛋白是由海洋贻贝分泌的具有特殊粘性的一种蛋白，它具有高强度、高韧性、耐强酸、耐强碱、生物相容性好、无毒副作用、不发生免疫反应、可降解的优点，而且贻贝粘蛋白为碱性蛋白，在人体生理环境下分子表面带正电荷，容易吸附带负电的细胞，本发明首次采用贻贝粘蛋白对牙种植体进行表面处理的方法，经本发明处理过的牙种植体无副作用，用能快速促进种植体与牙槽骨的结合。
具体实施方式
以下对本发明的优选实施例进行说明，应当理解，此处所描述的优选实施例仅用于说明和解释本发明，并不用于限定本发明。
实施例1
一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，包括以下步骤:
1 ）、采用纯钛材料机械加工制备牙种植体；
2 ）、将牙种植体进行喷砂酸蚀（SLA）处理；
3 ）、将牙种植体在浓度为10mg/L的贻贝粘蛋白溶液中浸泡为2h处理。
实施例2
一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，包括以下步骤:
1 ）、采用纯钛材料机械加工制备牙种植体；
2 ）、将牙种植体进行喷砂酸蚀（SLA）处理；
3 ）、将牙种植体在浓度为200mg/L的贻贝粘蛋白溶液中浸泡为0.5h处理。
实施例3
一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，包括以下步骤:
1 ）、采用纯钛材料机械加工制备牙种植体；
2 ）、将牙种植体进行喷砂酸蚀（SLA）处理；
3 ）、将牙种植体在浓度为100mg/L的贻贝粘蛋白溶液中浸泡为1h处理。
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。所有涉及采用贻贝粘蛋白用做表面处理的都属专利侵权。

Claims (3)

  1. 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法，其特征在于,包括以下步骤:
    1）、采用纯钛材料机械加工制备牙种植体；
    2）、将牙种植体进行喷砂酸蚀（SLA）处理；
    3）、将牙种植体在贻贝粘蛋白溶液中浸泡处理。
  2. 如权利要求1所述的快速促进牙种植体与牙槽骨结合的牙种植体处理方法，其特征在于，所述步骤3）中贻贝粘蛋白的浓度为10～200mg/L。
  3. 如权利要求2所述的快速促进牙种植体与牙槽骨结合的牙种植体处理方法，其特征在于,所述步骤3）中牙种植体在贻贝粘蛋白溶液中浸泡时间为0.5～2h。
PCT/CN2016/113717 2016-12-30 2016-12-30 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法 WO2018120113A1 (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111759502A (zh) * 2020-07-25 2020-10-13 上海捷美生物技术有限公司 一种亲水性种植体的制备装置及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241281A1 (en) * 2001-07-20 2006-10-26 Messersmith Phillip B Peptidomimetic polymers for antifouling surfaces
CN102525673A (zh) * 2010-10-07 2012-07-04 长庚医学科技股份有限公司 一种牙植体表面处理的方法
CN102989039A (zh) * 2012-09-29 2013-03-27 西安中邦种植体技术有限公司 一种具备生物活性的种植体制备方法
CN205459150U (zh) * 2016-01-07 2016-08-17 江苏创英医疗器械有限公司 一种牙科种植体
CN106821522A (zh) * 2016-12-30 2017-06-13 江阴金泰克生物技术有限公司 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241281A1 (en) * 2001-07-20 2006-10-26 Messersmith Phillip B Peptidomimetic polymers for antifouling surfaces
CN102525673A (zh) * 2010-10-07 2012-07-04 长庚医学科技股份有限公司 一种牙植体表面处理的方法
CN102989039A (zh) * 2012-09-29 2013-03-27 西安中邦种植体技术有限公司 一种具备生物活性的种植体制备方法
CN205459150U (zh) * 2016-01-07 2016-08-17 江苏创英医疗器械有限公司 一种牙科种植体
CN106821522A (zh) * 2016-12-30 2017-06-13 江阴金泰克生物技术有限公司 一种快速促进牙种植体与牙槽骨结合的牙种植体处理方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG ZHONGSHAN ET AL.: "The Influence of Titanium Surface coating with Mussel Adhesive Protein on the growth of Human skin-derived fibroblasts", PROCEEDING OF THE 16TH NATIONAL EPOXY RESIN APPLICATION TECHNOLOGY ACADEMIC SEMINAR AND SOCIETY NORTHWEST DISTRICT BRANCH 5TH ACADEMIC SYMPOSIUM AND XI'AN TECHNIQUE ASSOCIATION ACADEMIC SYMPOSIUM, 31 December 2012 (2012-12-31), pages 433 - 443 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111759502A (zh) * 2020-07-25 2020-10-13 上海捷美生物技术有限公司 一种亲水性种植体的制备装置及方法

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