WO2018117448A1 - Dispositif de diagnostic utilisant la salive et procédé de diagnostic correspondant - Google Patents

Dispositif de diagnostic utilisant la salive et procédé de diagnostic correspondant Download PDF

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Publication number
WO2018117448A1
WO2018117448A1 PCT/KR2017/013487 KR2017013487W WO2018117448A1 WO 2018117448 A1 WO2018117448 A1 WO 2018117448A1 KR 2017013487 W KR2017013487 W KR 2017013487W WO 2018117448 A1 WO2018117448 A1 WO 2018117448A1
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WO
WIPO (PCT)
Prior art keywords
saliva
layer
diagnostic device
diagnostic
disease
Prior art date
Application number
PCT/KR2017/013487
Other languages
English (en)
Korean (ko)
Inventor
신익수
우희제
장인수
김동철
Original Assignee
주식회사 동운아나텍
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020170013783A external-priority patent/KR101883412B1/ko
Priority to SI201731437T priority Critical patent/SI3561507T1/sl
Priority to LTEPPCT/KR2017/013487T priority patent/LT3561507T/lt
Priority to RS20231071A priority patent/RS64958B1/sr
Priority to FIEP17861188.5T priority patent/FI3561507T3/fi
Priority to PL17861188.5T priority patent/PL3561507T3/pl
Priority to EP23182930.0A priority patent/EP4227679A1/fr
Priority to DK17861188.5T priority patent/DK3561507T3/da
Application filed by 주식회사 동운아나텍 filed Critical 주식회사 동운아나텍
Priority to EP23182929.2A priority patent/EP4227678A1/fr
Priority to US15/766,270 priority patent/US20190298233A1/en
Priority to CN201780003592.4A priority patent/CN108474781B/zh
Priority to EP17861188.5A priority patent/EP3561507B1/fr
Priority to JP2018514435A priority patent/JP6628868B2/ja
Priority to ES17861188T priority patent/ES2962877T3/es
Publication of WO2018117448A1 publication Critical patent/WO2018117448A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G01N33/48792—Data management, e.g. communication with processing unit
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Definitions

  • the present invention relates to a diagnostic device using saliva and a diagnostic method using the same, and more particularly, to a device and method for diagnosing a disease using saliva.
  • the operating principle of the existing biosensor for diagnosing diseases is an invasive blood collection method for diagnosing all blood, and is an individual diagnostic device for one purpose such as blood glucose measurement and cancer measurement for diabetics.
  • saliva saliva (saliva) using the diagnosis of the disease, and the saliva that can be utilized (measured) for each specific use (disease) by reacting the detection unit suitable for a specific use (disease) with saliva
  • saliva saliva (saliva) using the diagnosis of the disease
  • saliva that can be utilized (measured) for each specific use (disease) by reacting the detection unit suitable for a specific use (disease) with saliva
  • a diagnostic device the detection unit is detachably coupled to the diagnostic device, for detecting a disease using saliva (saliva); Communication unit; And a controller configured to apply a voltage to the detector, convert the diagnostic data provided through the detector into a digital signal, and provide the digital signal to a user terminal through the communication unit.
  • the detection unit may induce an electrochemical reaction of the disease agent in the saliva through a voltage applied through the diagnostic device, and provide the controller with a current generated by the electrochemical reaction of the disease agent.
  • the detection unit may include a device connection unit receiving a voltage from the diagnosis device and providing a current generated by an electrochemical reaction of a disease agent in the saliva to the diagnosis device; And a saliva detection unit for inducing an electrochemical reaction of a disease agent in the saliva through a voltage applied from the diagnostic device through the device connection unit, and providing a current generated by the electrochemical reaction of the disease agent to the device connection unit. It may include.
  • the saliva detection unit may include a first layer including an electrode connected to the device connection unit; A second layer attached on top of the first layer to induce an electrochemical reaction of the disease agent in the saliva; A third layer on the second layer, the third layer comprising an enzyme capable of recognizing a disease agent in the saliva; A fourth layer disposed on the third layer and formed of a filter for separating a predetermined material; And a fifth layer positioned on the fourth layer and composed of a composite fibrous membrane.
  • the disease agent may be a specific factor capable of diagnosing a disease.
  • the second layer may be composed of a nanostructure made of a porous metal-organic solid structure.
  • the nanostructure has a chemical composition of M a (II) M ′ b (III) (CN) 6 , wherein M and M ′ may be metal elements.
  • the digital signal may be converted into a concentration of disease agent by the user terminal based on a preset calibration curve.
  • a diagnostic method using a diagnostic device using saliva comprising: applying a voltage to a detection unit detachably coupled to the diagnostic device; Diagnosing a disease using saliva by the detection unit; Converting the diagnostic data received through the detection unit into a digital signal; And providing the digital signal to a user terminal through a communication network.
  • the disease diagnosis step may include inducing an electrochemical reaction of the disease agent in the saliva through a voltage applied to the detection unit through the diagnosis device, and detecting a current generated by the electrochemical reaction of the disease agent. .
  • the detection unit may include a device connection unit receiving a voltage from the diagnosis device and providing a current generated by an electrochemical reaction of a disease agent in the saliva to the diagnosis device; And a saliva detection unit for inducing an electrochemical reaction of a disease agent in the saliva through a voltage applied from the diagnostic device through the device connection unit, and providing a current generated by the electrochemical reaction of the disease agent to the device connection unit. It may include.
  • the saliva detection unit may include a first layer including an electrode connected to the device connection unit; A second layer attached on top of the first layer to induce an electrochemical reaction of the disease agent in the saliva; A third layer on the second layer, the third layer comprising an enzyme capable of recognizing a disease agent in the saliva; A fourth layer disposed on the third layer and formed of a filter for separating a predetermined material; And a fifth layer positioned on the fourth layer and composed of a composite fibrous membrane.
  • the disease agent may be a specific factor capable of diagnosing a disease.
  • the second layer may be composed of a nanostructure made of a porous metal-organic solid structure.
  • the nanostructure has a chemical composition of M a (II) M ′ b (III) (CN) 6 , wherein M and M ′ may be metal elements.
  • the digital signal may be converted into a concentration of disease agent by the user terminal based on a preset calibration curve.
  • the computer program according to the present invention for achieving the above technical problem is stored in a computer-readable recording medium to execute any one of the above methods in a computer.
  • the diagnostic device using the saliva and the diagnostic method using the same it is possible to diagnose the disease without pain several times a day using saliva (saliva) rather than blood.
  • the detection unit may be selected and measured for each specific use (disease), thereby providing an economic advantage.
  • the user can manage the health through the measurement result can be self-care for each individual.
  • FIG. 1 is a block diagram illustrating a diagnostic device using saliva according to a preferred embodiment of the present invention.
  • FIG. 2 is a diagram for explaining an example of the diagnostic device shown in FIG. 1.
  • FIG. 3 is a block diagram showing the configuration of the diagnostic device shown in FIG. 1 in more detail.
  • FIG. 4 is a block diagram illustrating in detail the configuration of the detector illustrated in FIG. 3.
  • FIG. 5A is a diagram for explaining an example of the detection unit illustrated in FIG. 3, and FIG. 5B is a cross-sectional view of part A-A 'shown in FIG.
  • FIG. 6 is a view for explaining a state in which a protective cover part is separated from the detection unit shown in FIG. 5.
  • FIG. 7 is a view showing in more detail the configuration of the saliva detection unit shown in FIG. 5.
  • FIG. 8 is a view for explaining an example of the individual process of disease diagnosis according to a preferred embodiment of the present invention.
  • FIG. 9 is a view for explaining an example of the entire process of disease diagnosis in accordance with a preferred embodiment of the present invention.
  • FIG. 10 is a graph for explaining an example of a disease diagnosis result according to a preferred embodiment of the present invention.
  • FIG. 11 is a flowchart illustrating a diagnostic method using a diagnostic device using saliva according to a preferred embodiment of the present invention.
  • FIGS. 1 and 2 First, a diagnosis device using saliva according to a preferred embodiment of the present invention will be described with reference to FIGS. 1 and 2.
  • FIG. 1 is a block diagram for explaining a diagnostic device using saliva according to a preferred embodiment of the present invention
  • Figure 2 is a view for explaining an example of the diagnostic device shown in FIG.
  • a diagnosis device 100 using saliva according to the present invention (hereinafter referred to as a “diagnosis device”) is connected to a user terminal 200 through a communication network 300.
  • the diagnostic device 100 diagnoses the disease by an electrochemical method using saliva rather than blood.
  • the diagnostic device 100 may be utilized (measured) for each specific use (disease) by reacting a detection unit suitable for a specific use (disease) with saliva.
  • the diagnostic device 100 converts the diagnostic data into a digital signal and provides the diagnostic data to the user terminal 200 through the communication network 300.
  • the user terminal 200 may be connected to the diagnostic device 100 through the communication network 300 to exchange various data.
  • the user terminal 300 may convert the digital signal provided from the diagnostic device 100 through the communication network 300 to the concentration of the disease agent based on a preset calibration curve.
  • the disease factor is a specific factor capable of diagnosing a disease and refers to antigen, glucose, and the like.
  • the correction curve is made of a current value according to the concentration of glucose, and may be obtained in advance through a previous experiment or the like.
  • the user terminal 300 may display the converted disease agent concentration.
  • the diagnostic device when the diagnostic device according to the present invention diagnoses diabetes, the glucose concentration for diabetes is already quantified, and the diagnosis and diabetes (ie, the quantified glucose concentration) can be used to diagnose diabetes.
  • the user terminal 200 is not only a desktop computer but also a laptop computer, a workstation, a palmtop computer, a UMPC (Ultra Mobile Personal Computer), a tablet PC, a personal digital assistant (PDA), a web pad, It may be configured as a terminal having a computing capability by mounting a microprocessor such as a smart phone or a mobile phone.
  • a microprocessor such as a smart phone or a mobile phone.
  • the communication network 300 may include a telephone network as well as a data communication network including a local area network (LAN), a metropolitan area network (MAN), a wide area network (WAN), the Internet, and the like. It can be used, and it does not matter wired and wireless, and it does not matter which communication method is used.
  • LAN local area network
  • MAN metropolitan area network
  • WAN wide area network
  • the Internet and the like. It can be used, and it does not matter wired and wireless, and it does not matter which communication method is used.
  • FIG. 3 is a block diagram showing the configuration of the diagnostic device shown in FIG. 1 in more detail.
  • the diagnostic device 100 includes a communication unit 110, a DAC unit 120, an ADC unit 130, a power supply unit 140, a voltage applying unit 150, a detection unit 160, and a control unit 170. It may include.
  • the communication unit 110 includes a wired communication module (not shown) or a wireless communication module (not shown), and performs transmission / reception of corresponding data for wired / wireless communication of the diagnostic device 100.
  • the communication unit 110 may transmit data provided from other components of the diagnostic device 100 to the user terminal 200 through the communication network 300.
  • the DAC unit 120 converts the digital signal into an analog signal under the control of the controller 170.
  • the ADC unit 130 converts the analog signal into a digital signal under the control of the controller 170.
  • the power supply unit 140 includes a battery (not shown), and supplies power required for the operation of each component of the diagnostic device 100.
  • the battery may be an integrated battery fixed to the diagnostic device 100 or a removable battery detachable to the diagnostic device 100.
  • the power supply unit 140 may receive power from an external power source (not shown).
  • the voltage applying unit 150 applies a constant voltage to the detector 160 under the control of the controller 170.
  • the voltage applying unit 150 measures the current generated by the detection unit 160 and provides it to the control unit 170.
  • the detection unit 160 is detachably coupled to the diagnosis device 100 and diagnoses a disease using saliva. That is, the detection unit 160 induces an electrochemical reaction (ie, a redox reaction) of a disease agent in saliva sampled through the voltage applied through the voltage applying unit 150.
  • an electrochemical reaction ie, a redox reaction
  • the detector 160 provides the diagnostic data to the controller 170. That is, the detection unit 160 provides the current generated by the electrochemical reaction of the disease agent to the control unit 170 through the voltage applying unit 150.
  • the controller 170 controls the overall operation of each component of the diagnostic device 100.
  • the controller 170 controls the voltage applying unit 150 to apply a voltage to the detector 160.
  • the controller 170 converts the diagnostic data provided through the detector 160 into a digital signal through the ADC 130. That is, the controller 170 may measure the current generated by the detector 160 through the voltage applying unit 150 by the electrochemical reaction of the disease agent, and convert the measured result into a digital signal.
  • the controller 170 provides a digital signal to the user terminal 200 through the communication unit 110. Then, the user terminal 300 converts the digital signal provided from the diagnostic device 100 to the concentration of disease agent based on a preset calibration curve.
  • FIG. 4 is a block diagram illustrating in detail the configuration of the detector illustrated in FIG. 3.
  • the detector 160 may include a device connection unit 161, a saliva detection unit 163, and a protective cover unit 165.
  • the device connection unit 161 receives a voltage from the diagnostic device 100. In addition, the device connection unit 161 provides the diagnostic device 100 with a current generated by an electrochemical reaction of a disease agent in saliva.
  • the saliva detection unit 163 induces an electrochemical reaction of a disease agent in saliva through a voltage applied from the diagnostic device 100 through the device connection unit 161.
  • the saliva detection unit 163 provides the device connection unit 161 with a current generated by the electrochemical reaction of the disease agent.
  • the saliva of the patient may be sampled by the patient spitting out saliva to the saliva detection unit 163 or by directly contacting the saliva detection unit 163 to the oral affected part of the patient. That is, the saliva detection unit 163 may mix the saliva sample of the patient, and may serve as a reactor in which the electrochemical reaction proceeds.
  • the protective cover part 165 is a housing for protecting the device connection part 161 and the saliva detection part 163 from external substances, magnetic poles, and the like.
  • FIG. 5A is a view for explaining an example of the detection unit shown in FIG. 3
  • (b) is a cross-sectional view of the AA ′ portion shown in (a)
  • FIG. 6 is a protective cover in the detection unit shown in FIG.
  • Figure 7 is a view for explaining the separated state
  • Figure 7 is a view showing in more detail the configuration of the saliva detection unit shown in Figure 5
  • Figure 8 illustrates an example of the individual process of disease diagnosis according to a preferred embodiment of the present invention
  • 9 is a view for explaining an example of the entire process of disease diagnosis according to a preferred embodiment of the present invention
  • Figure 10 is a view for explaining an example of a disease diagnosis result according to a preferred embodiment of the present invention It is a graph.
  • the saliva detection unit 163 may be formed of a plurality of layers L1 to L5.
  • the fifth layer L5 is located above the fourth layer L4 and consists of a composite fibrous membrane. That is, as shown in (a) of FIG. 8, when saliva SL comes in contact with the fifth layer L5 formed of the composite fibrous membrane, the fifth layer L5 is in contact with the entire saliva of the composite fibrous membrane. To spread.
  • the fourth layer L4 is positioned on the third layer L3 and is formed of a filter for separating a predetermined material. That is, as shown in FIG. 8B, the fourth layer L4 separates a predetermined material from among a plurality of materials included in saliva.
  • saliva contains many substances such as protein, amylase, and urea in addition to glucose, and the fourth layer (L4) may separate substances that interfere with glucose detection.
  • the disease agent is other than glucose, it is possible to isolate a substance that interferes with the detection of other factors.
  • the third layer (L3) is located on the second layer (L2), made of an enzyme that can recognize the disease agent in saliva. That is, as shown in (c) of FIG. 8, when the disease agent is glucose, the third layer (L3) decomposes glucose into hydrogen peroxide and Gluconic acid. In addition, when the disease agent is a factor other than glucose, the third layer (L3) may be made of an enzyme that can recognize other factors in saliva. Accordingly, in the present invention, the saliva detection unit 163 may be configured as the third layer L3 capable of recognizing a disease factor related to the disease to be measured. As such, the detection unit may be selected and measured according to a specific use (disease), and thus the present invention may provide an economic advantage to selectively recognize various disease factors as well as glucose.
  • the second layer L2 is attached on the first layer L1 to induce an electrochemical reaction of disease agent in saliva. That is, as shown in (d) of FIG. 8, when the disease agent is glucose, the second layer L2 reduces hydrogen peroxide generated during the glucose decomposition process of the third layer L3 and oxidizes itself. Current is generated in the process of sending and receiving electrons.
  • the second layer (L2) may be composed of a nanostructure made of a porous metal-organic solid structure. Nanostructures are non-toxic catalysts with no biohazards, which reduce the output of glucose metabolism by electrochemical methods and oxidize themselves at the electrodes to generate current signals.
  • the nanostructure has a chemical composition of M a (II) M ′ b (III) (CN) 6 , and M and M ′ may be metal elements.
  • M 2+ and M '3 + a metal cation and CN - to promote rapid reduction of the solids is water structure consisting of cyanide anion coordinated water metabolism of the enzyme by the electrochemical catalytic properties of the central metal cation of hydrogen peroxide .
  • M and M ' is a metal element Fe, Zn, K, Mg, Al, Cu, Co, Ni, Cr, and the like can be Mn, Rb, as an example nanostructure is based on Fe 2 + and Fe 3 + It may be a Prussian blue structure, Fe 4 III [Fe II (CN) 6 ] 3 .
  • the saliva detection unit 163 having a high sensitivity may be configured through the nanostructure.
  • the first layer L1 is formed of an electrode connected to the device connection part 161. That is, the first layer L1 provides the device connection unit 161 with the current generated in the second layer L2.
  • the first layer (L1) is shown in the drawing as a three-electrode (three-electrodes) consisting of the reference electrode (EN1), the working electrode (EN2) and the auxiliary electrode (EN3), but is not limited to this embodiment Accordingly, the first layer L1 may be configured in the form of two-electrodes.
  • the saliva detection unit 163 may further include a filtration membrane or a thin membrane. can do.
  • the saliva detection unit 163 may further include a filtration membrane capable of sensing only a specific disease agent from various interference substances in the saliva.
  • the saliva detection unit 163 may further include a thin film for the role of an electrolyte and a protein or DNA material that exhibits selective electrochemical signal response to disease factors only.
  • FIG. 11 is a flowchart illustrating a diagnostic method using a diagnostic device using saliva according to a preferred embodiment of the present invention.
  • the diagnostic device 100 applies a constant voltage to the detector 160 coupled to the diagnostic device 100 (S110).
  • the diagnosis device 100 diagnoses a disease using saliva (S130). That is, the detection unit 160 induces an electrochemical reaction of the disease agent in the saliva sampled through the applied voltage. In addition, the detection unit 160 provides the current generated by the electrochemical reaction of the disease agent to the diagnostic device 100.
  • the diagnostic device 100 converts the diagnostic data (that is, the result of measuring the current generated by the detection unit 160) into a digital signal (S150).
  • the diagnostic device 100 provides a digital signal to the user terminal 200 through the communication network 300 (S170). Then, the user terminal 200 converts the digital signal provided from the diagnostic device 100 to the concentration of disease agent based on a preset calibration curve.
  • the invention can also be embodied as computer readable code on a computer readable recording medium.
  • the computer-readable recording medium includes all kinds of recording devices in which data that can be read by a computer is stored. Examples of computer-readable recording media include ROM, RAM, CD-ROM, magnetic tape, floppy disk, optical data storage, and also carrier wave (over the Internet). Transmission).
  • the computer-readable recording medium can also be distributed over computer devices connected over a wired or wireless communication network so that the computer-readable code is stored and executed in a distributed fashion.

Abstract

L'invention concerne un dispositif de diagnostic utilisant la salive et un procédé de diagnostic correspondant. La présente invention permet de diagnostiquer des maladies en utilisant la salive et non le sang ; permet une utilisation en fonction d'une utilisation spécifique (ou permet la mesure d'une maladie spécifique) par la réaction d'une partie détection correspondant à l'utilisation (ou maladie) spécifique avec la salive ; permet de diagnostiquer une maladie plusieurs fois par jour sans aucune douleur en utilisant la salive ; présente un avantage économique par la sélection d'une partie détection en fonction d'une utilisation (ou maladie) spécifique afin de détecter la maladie spécifique ; et permet de fournir un résultat de mesure à un terminal utilisateur de telle sorte qu'un utilisateur puisse gérer sa santé en fonction du résultat de mesure, ce qui permet un soin de santé personnalisé autonome.
PCT/KR2017/013487 2016-12-21 2017-11-24 Dispositif de diagnostic utilisant la salive et procédé de diagnostic correspondant WO2018117448A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES17861188T ES2962877T3 (es) 2016-12-21 2017-11-24 Dispositivo de diagnóstico y método de diagnóstico para mediciones de saliva
DK17861188.5T DK3561507T3 (da) 2016-12-21 2017-11-24 Diagnoseapparat og diagnosefremgangsmåde til målinger på spyt
RS20231071A RS64958B1 (sr) 2016-12-21 2017-11-24 Aparatura za dijagnostiku i dijagnostički postupak za merenјa iz pljuvačke
FIEP17861188.5T FI3561507T3 (fi) 2016-12-21 2017-11-24 Diagnostinen laite ja diagnostinen menetelmä syljestä tehtäviä mittauksia varten
PL17861188.5T PL3561507T3 (pl) 2016-12-21 2017-11-24 Aparat diagnostyczny i sposób diagnostyczny do pomiarów w ślinie
EP23182930.0A EP4227679A1 (fr) 2016-12-21 2017-11-24 Appareil de diagnostic et procédé de diagnostic pour des mesures sur la salive
EP23182929.2A EP4227678A1 (fr) 2016-12-21 2017-11-24 Appareil de diagnostic et procédé de diagnostic pour des mesures sur la salive
SI201731437T SI3561507T1 (sl) 2016-12-21 2017-11-24 Diagnostični aparat in diagnostična metoda za meritve na slini
LTEPPCT/KR2017/013487T LT3561507T (lt) 2016-12-21 2017-11-24 Diagnostikos aparatas ir diagnostikos būdas matavimui naudojant seiles
US15/766,270 US20190298233A1 (en) 2016-12-21 2017-11-24 Diagnosis device using saliva and diagnosis method using the same
CN201780003592.4A CN108474781B (zh) 2016-12-21 2017-11-24 利用唾液的诊断设备
EP17861188.5A EP3561507B1 (fr) 2016-12-21 2017-11-24 Appareil de diagnostic et procédé de diagnostic de mesures sur la salive
JP2018514435A JP6628868B2 (ja) 2016-12-21 2017-11-24 唾液を用いた診断デバイス及びこれを利用する分析方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160175951 2016-12-21
KR10-2016-0175951 2016-12-21
KR10-2017-0013783 2017-01-31
KR1020170013783A KR101883412B1 (ko) 2016-12-21 2017-01-31 타액을 이용한 진단 디바이스 및 이를 이용한 분석 방법

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WO2018117448A1 true WO2018117448A1 (fr) 2018-06-28

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020013093A1 (fr) * 2018-07-09 2020-01-16 国立研究開発法人物質・材料研究機構 Dispositif de diagnostic, procédé d'analyse et programme
CN113176411A (zh) * 2021-03-10 2021-07-27 北京大学口腔医学院 利用唾液检测新型冠状病毒肺炎的生物标志物及其应用

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