WO2020162650A1 - Procédé de fabrication d'une étiquette de capteur électrochimique au moyen d'un procédé d'impression par gravure r2r - Google Patents

Procédé de fabrication d'une étiquette de capteur électrochimique au moyen d'un procédé d'impression par gravure r2r Download PDF

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WO2020162650A1
WO2020162650A1 PCT/KR2019/001598 KR2019001598W WO2020162650A1 WO 2020162650 A1 WO2020162650 A1 WO 2020162650A1 KR 2019001598 W KR2019001598 W KR 2019001598W WO 2020162650 A1 WO2020162650 A1 WO 2020162650A1
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Prior art keywords
electrode
electrochemical sensor
printing
electrode pattern
conductive
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PCT/KR2019/001598
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English (en)
Korean (ko)
Inventor
조규진
정연수
손준봉
박혜진
Original Assignee
순천대학교 산학협력단
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Publication of WO2020162650A1 publication Critical patent/WO2020162650A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M1/00—Inking and printing with a printer's forme
    • B41M1/10—Intaglio printing ; Gravure printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M1/00—Inking and printing with a printer's forme
    • B41M1/26—Printing on other surfaces than ordinary paper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
    • B41M3/00—Printing processes to produce particular kinds of printed work, e.g. patterns
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
    • C09D11/037—Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/10—Printing inks based on artificial resins
    • C09D11/106—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/52—Electrically conductive inks
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/067—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components
    • G06K19/07—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components with integrated circuit chips
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B1/00—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors
    • H01B1/06—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances
    • H01B1/12—Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of other non-metallic substances organic substances
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B3/00—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties
    • H01B3/18—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of organic substances
    • H01B3/30—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of organic substances plastics; resins; waxes
    • H01B3/44—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of organic substances plastics; resins; waxes vinyl resins; acrylic resins
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K3/00—Apparatus or processes for manufacturing printed circuits
    • H05K3/10—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
    • H05K3/12—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors

Definitions

  • the present invention relates to a method of manufacturing an electrochemical sensor using an R2R (Roll-to-Roll) gravure printing method, and specifically, a method of manufacturing an electrochemical sensor tag applicable to a wearable medical device using an R2R gravure printing method About.
  • Wearable devices which are widely distributed, mostly provide only functions to measure movement distance or momentum or measure pulse.
  • a smart watch that works with a smart phone is also not far away from such a function.
  • a portable medical device that simplifies a blood sugar blood pressure test as a wearable medical device for diagnosing biometric information is being actively developed.
  • Google is working with global pharmaceutical company Novartis to develop a smart contact lens that checks for diabetes by regularly checking the glucose in tears. Apple is also conducting research to equip the "Apple Watch” with a function that checks blood sugar and blood pressure from time to time.
  • the Ulsan Institute of Science and Technology in Korea developed a smart contact lens that can be worn on the eyes and checked for blood sugar through LEDs.
  • the smart contact lens unveiled by the Ulsan Institute of Science and Technology can easily check the blood sugar level by blinking the LED.
  • the healthcare smart dressing which is aimed at commercialization in 2020, is implemented as a system that measures the temperature of the wound (wound) where the skin is peeled off and the pH value of exudate from the wound using a biosensor and transmits it to a mobile phone or a dedicated terminal. do.
  • a wireless communication biosensor is applied that helps the patient himself, his or her guardian, or a medical staff located at a distance to check whether there is bacterial infection in the wound area in real time.
  • a smart bandage that integrates pH and temperature sensors to monitor the wound.
  • This smart bandage has built-in pH and temperature sensors that track infection and inflammation, so that the collected data can accurately measure the condition of the wound and provide correct medication based on it.
  • the pH measured from the wound is an important factor for monitoring the healing process of chronic wounds, the pH index of a normal wound is 5.5 to 6.5, and the infected wound has a pH index greater than 6.5.
  • a microprocessor mounted in a smart bandage is implemented to inject drugs while collecting data from pH and temperature sensors.
  • Medtronic a renowned medical device company in the United States, has developed a vest-type wearable medical device that diagnoses cardiac arrhythmia.
  • This vest is equipped with a total of 252 electrode sensors, allowing users to perform atrial and ventricular examinations while wearing clothes as usual.
  • ECG electrocardiogram
  • CT scan images of the examined data
  • the heart structure is reconstructed into a 3D electro-anatomical image to be displayed.
  • the present invention has been conceived to solve the above-described problems, and an object of the present invention is to provide a method of manufacturing an electrochemical sensor tag that can be applied to a wearable medical device using an R2R gravure printing method.
  • the present invention uses an R2R gravure printing method to print electrochemical sensor electrodes (working electrode, reference electrode, and auxiliary electrode) using hydrophobic Ag nanoparticle ink and conductive carbon ink to implement a three-electrode system. It provides a method of manufacturing a sensor tag.
  • the present invention is to provide a method of manufacturing an electrochemical sensor tag that can be implemented in a flexible form by printing an insulating layer that prevents each electrode constituting a three-electrode system from being electrically connected to other elements using polyethylene insulating ink.
  • the present invention is to provide a method for manufacturing an electrochemical sensor tag that can be used as a medical device capable of selectively detecting glucose, pH, K + , Na + , Cu 2+ , caffeine, etc. through chemical treatment on the surface of a working electrode. .
  • the present invention is to provide a method of manufacturing an electrochemical sensor tag capable of detecting glucose (or caffeine, K +, etc.) in a non-blood sampling method.
  • An object of the present invention is to provide a manufacturing method for an electrochemical sensor that can be produced at an ultra-low cost in large quantities through a roll-to-roll (R2R) gravure printing device and an application of a wearable medical device using the same.
  • R2R roll-to-roll
  • the method of manufacturing an electrochemical sensor tag using the R2R gravure printing method according to the present invention includes the steps of printing first to third conductive wires spaced apart from each other on a flexible substrate of a PET film using hydrophobic Ag nanoparticle ink, Printing a first electrode pattern using conductive carbon ink on at least a portion of the first conductive wiring and the third conductive wiring, and a second electrode using AgCl ink on at least a portion of the second conductive wiring And printing a pattern, wherein the first electrode pattern is an auxiliary electrode or a reference electrode, and the third electrode pattern is a working electrode to form a three electrode system.
  • a third electrode using a material sensitive to at least one of pH, Na + , K + , glucose, and caffeine on at least a portion of the third conductive wiring on which the first electrode pattern is printed may further include the step of forming a pattern.
  • the printing of the plurality of conductive wires includes a viscosity of 80 to 150 cp and a tension of 28 to 33 mN/m using polyvinyl butyral (PVB) and terpineol.
  • Eggplant may include the step of preparing the Ag nanoparticle ink.
  • the step of forming the reference electrode by sequentially coating an agarose gel and an SU-8 photoresist on an upper portion on which the second electrode pattern is printed may be further included.
  • the method of manufacturing an electrochemical sensor tag according to the present invention includes a viscosity of 250 to 350 cP and a surface tension of 28 to 33 mN/m using polyethylene and ethylene glycol monoethyl ether acetate (ECA).
  • ECA polyethylene and ethylene glycol monoethyl ether acetate
  • the step of preparing an insulating ink having, and printing an insulating layer on the conductive wiring excluding the first electrode pattern, the second electrode pattern, and or the third electrode pattern using the insulating ink. can include.
  • the printing of the first electrode pattern includes preparing the conductive carbon ink having a viscosity of 250 to 350 cP and a surface tension of 30 to 33 mN/m using the ECA. can do.
  • the printing of the third electrode pattern includes preparing a conductive polyaniline ink using polyaniline and camphorsulfonic acid (CSA), and the conductive polyaniline ink of the third conductive wiring. It may include the step of forming a working electrode sensitive to the pH by printing on at least a portion.
  • CSA polyaniline and camphorsulfonic acid
  • the method of manufacturing an electrochemical sensor tag according to the present invention may further include bonding a chip to the first to third conductive wires.
  • an electrochemical sensor tag that has high sensitivity to various factors such as pH, Na+, K+, and glucose and is flexible and easy to attach to the human body at a low unit price.
  • the electrochemical sensor tag manufacturing method includes a printing Ag/AgCl reference electrode manufacturing method having a constant potential, an insulating layer ink manufacturing method for protecting the electrode and minimizing the influence of the external environment, and a polyaniline/carbon-based pH sensitive operation.
  • An electrode manufacturing method may be provided, and as a wearable medical device, an electrochemical sensor tag capable of reading pH (or glucose) from sweat of human skin without blood collection may be provided.
  • the method of manufacturing an electrochemical sensor tag according to the present invention may provide an electrochemical sensor tag capable of functioning as a low-cost wearable electrochemical multi-sensor in connection with an NFC function of a smartphone.
  • FIG. 1 is a flowchart illustrating a method of manufacturing an electrochemical sensor tag according to an embodiment of the present invention
  • FIG. 2 is a method of manufacturing an electrochemical sensor tag using an R2R gravure printing method according to an embodiment of the present invention. It is a schematic diagram for explanation.
  • 3 to 7 are plan views illustrating an embodiment of an electrochemical sensor tag according to a method of manufacturing an electrochemical sensor tag.
  • FIG. 8 is a view showing an electrochemical sensor tag actually printed using the R2R gravure printing method according to an embodiment of the present invention.
  • FIG. 9 is a plan view showing an electrochemical sensor tag connected to a chip according to an embodiment of the present invention.
  • FIG. 10 is a graph showing different potentials according to pH of an electrochemical sensor tag manufactured according to an embodiment of the present invention, and a graph showing a voltage change according to a continuous pH change.
  • FIG. 12 is a diagram showing a state in which a printed antenna and a chip are bonded to a completed electrochemical sensor tag to communicate with a smart phone.
  • FIG. 1 is a flowchart illustrating a method of manufacturing an electrochemical sensor tag according to an embodiment of the present invention
  • FIG. 2 is a method of manufacturing an electrochemical sensor tag using an R2R gravure printing method according to an embodiment of the present invention. It is a schematic diagram for explanation.
  • 3 to 7 are plan views illustrating an embodiment of an electrochemical sensor tag according to a method of manufacturing an electrochemical sensor tag.
  • the method of manufacturing an electrochemical sensor tag according to the present invention is based on a continuous R2R gravure printing process, and thus, an electrochemical sensor tag can be mass-produced at a low cost.
  • a PET (polyethylene terephthalate) film substrate is prepared to print the electrochemical sensor (step S110).
  • the PET film substrate may be prepared in a rolled form.
  • the electrochemical sensor wiring and the conductive wiring serving as an electrode are printed on the PET substrate using a hydrophobic Ag nanoparticle ink (step S120).
  • a hydrophobic Ag nanoparticle ink Conventional Ag nanoparticle-based inks for gravure are not suitable for aqueous solution-based measurements due to their hydrophilic properties.
  • the pH measurement is facilitated by using the Ag nanoparticle ink having hydrophobic properties, and further, the conductive wiring using the Ag nanoparticle ink has high conductivity and low resistance.
  • an electrochemical sensor circuit using a three-electrode system is implemented, and the conductive wire may include at least three spaced conductive wires.
  • FIG. 3 is a plan view showing an embodiment of an electrochemical sensor tag on which a plurality of conductive wires are printed according to the present invention.
  • three spaced apart conductive wires may include a first conductive wire 310, a second conductive wire 320, and a third conductive wire 330, which are not electrically connected respectively.
  • the first conductive wire 310 may be manufactured to correspond to the auxiliary electrode, the second conductive wire 320 to the reference electrode, and the third conductive wire 330 to correspond to the working electrode.
  • the conductive wires 310, 320, 330 may be composed of a measurement unit SEN and a connection unit CON, in which a current or voltage value is measured, and specifically, a measurement unit of the first conductive line 310 (SEN) may be an auxiliary electrode, a measurement unit SEN of the second conductive wiring 320 may be a reference electrode, and a measurement unit SEN of the third conductive wiring 330 may be a working electrode.
  • a measurement unit of the first conductive line 310 (SEN) may be an auxiliary electrode
  • a measurement unit SEN of the second conductive wiring 320 may be a reference electrode
  • a measurement unit SEN of the third conductive wiring 330 may be a working electrode.
  • the working electrode corresponds to an electrode in which an actual oxidation or reduction reaction takes place
  • the reference electrode is an electrode that serves as a reference for measuring an accurate voltage at the working electrode.
  • the auxiliary electrode does not directly participate in the reaction, does not affect the potential value, and is an electrode through which current flows. According to the three-electrode system, a voltage can be obtained through a reference electrode and a current value can be obtained through an auxiliary electrode.
  • Step S110 is a step of printing wirings that are basic for forming electrodes constituting a three-electrode system using a hydrophobic Ag nanoparticle ink, and in this step, a step of preparing a hydrophobic Ag nanoparticle ink.
  • Hydrophobic Ag nanoparticle ink is prepared to have a viscosity of 80 to 150 cp, and a surface tension of 28 to 33 mN/m, using PVB (Polyvinyl butyral) and terpineol for R2R gravure printing. I can.
  • the plurality of conductive wires may be dried for about 1 minute at 150° C. through a drying oven through an R2R process (see step S125 of FIG. 2).
  • a process of drying the printed or coated material for the next process may be involved (steps S135, S145, S155, and S165 of FIG. 2 Reference).
  • a first electrode pattern is printed on a part of the first conductive wire (310 of FIG. 4) and the third conductive wire (330 of FIG. 4) among the plurality of conductive wires (step S130).
  • the first electrode pattern may be printed on conductive wiring printed using hydrophobic Ag nanoparticle ink using conductive carbon ink.
  • FIG. 4 is a plan view showing an embodiment of an electrochemical sensor tag on which a first electrode pattern is printed.
  • a first electrode pattern 311 is printed on a partial area of the first conductive wire 310, specifically, on the measurement unit SEN of the first conductive wire 310, and the third conductive wire 310
  • the first electrode pattern 331 may be printed on a partial area of the wiring 330 and on the measurement unit SEN of the third conductive wiring 310.
  • the conductive carbon ink may be prepared to have a viscosity of 250 to 350 cP and a surface tension of 30 to 33 mN/m using Ethylene glycol monoethyl ether acetate (ECA).
  • ECA Ethylene glycol monoethyl ether acetate
  • a drying process may be performed (step S135 in FIG. 2 ).
  • an insulating layer may be printed in order to exclude an unintended reaction from the printed electrode surface or wiring portion (step S140).
  • the insulating layer cancels unintended chemical reactions and prevents unnecessary exposure of other parts other than the electrodes to the outside.
  • the insulating ink for printing the insulating layer may be prepared by adding an ECA solvent based on polyethylene (PE).
  • PE polyethylene
  • an insulating layer it is possible to apply an insulating layer (effectively used for short) to a printing element (for example, a printing transistor).
  • a printing element for example, a printing transistor.
  • an insulating ink having a viscosity of 250 to 350 cP and a surface tension of 28 to 33 mN/m may be prepared.
  • FIG. 5 is a plan view showing an electrochemical sensor tag on which an insulating layer is printed according to an embodiment of the present invention.
  • the conductive wires are electrically connected to other elements in addition to the measurement. Avoid contact with.
  • the insulating layer is printed after the first electrode pattern is printed, but the order in which the insulating layer is printed is not limited thereto.
  • drying step may be further performed after printing the insulating layer (step S145 of FIG. 2).
  • the second electrode pattern may be printed on a partial area of the second conductive wiring using Ag/AgCl ink (step S150).
  • FIG. 6 is a plan view showing an electrochemical sensor tag on which a second electrode pattern is printed according to an embodiment of the present invention.
  • the second electrode pattern 321 is printed on the measurement unit SEN of the second conductive line 320.
  • the step of printing the second electrode pattern is sequentially coating an agarose film saturated with 3 M KCl and an SU-8 photoresist (specifically, dip coating). It may include the step of. Accordingly, the measurement unit SEN of the second electrode pattern 320 may be manufactured as a reference electrode.
  • the printing of the second electrode pattern may use not only R2R gravure printing, but also inkjet or screen printing.
  • the Ag/AgCl electrode may be dip coated on SU-8 once more and then dried at 80° C. for 2 hours (step S155). .
  • the working electrode of the present invention has different voltage or current values in response to specific components.
  • printing by Ag nanoparticle ink and printing by conductive carbon ink are completed in the measurement unit SEN of the third conductive wiring.
  • Cu 2+ can be detected using a stripping voltammetry method even if no other additional process is performed afterwards.
  • an additional process may be included in order to implement a multi-sensor (sensitization to pH, Na + , K + , glucose, caffeine, etc.) (step S160).
  • This process may be understood as forming a third electrode pattern using a material sensitive to at least one of pH, Na + , K + , glucose, and caffeine on a partial region of the third conductive wiring.
  • FIG. 7 is a plan view illustrating an electrochemical sensor tag on which a third electrode pattern is formed according to an embodiment of the present invention.
  • the third electrode pattern 332 is formed on the measurement unit SEN of the third conductive line 330, it becomes possible to operate as a multi-sensor sensitive to a specific material.
  • it may further include printing a pH-sensitive third electrode pattern using a conductive polyaniline ink on a carbon/Ag electrode-based working electrode for pH sensitivity.
  • a conductive polyaniline ink polyaniline powder and CAS (camphorsulfonic acid) are ground in a mortar at a weight ratio of 1:1, and the mixed powder is mixed in a m-cresol solution in an amount of 1.6 wt%, and then Triethoxy(3-isocyanatopropyl) ) silane is added in an amount of 1 wt%, and after ultra-sonication of this mixture for about 3 hours, it can be prepared by dispersing using a homogenizer for about 1 hour.
  • the third electrode pattern may be printed using an inkjet or screen printing method.
  • the glucose oxidation solution may contain 100 ⁇ L of an aqueous PBS solution in 1 mg enzyme.
  • the electrochemical sensor tag can function as a caffeine-sensitive sensor.
  • a drying process may be performed (step S165 in FIG. 2).
  • FIG. 8 is a view showing an electrochemical sensor tag actually printed using the R2R gravure printing method according to an embodiment of the present invention.
  • the total electrochemical sensor size can be designed to correspond from 0.5 mm to 3.00 mm.
  • it is printed on a flexible and thin PET film base so that it can be used as a disposable electrode so that it is easy to deform, and it is designed to be cut and used as needed.
  • the electrochemical sensor tag printed in this way may be bonded to a chip for actual operation (step S170).
  • the chip may include a silicon-based chip, and may include a controller and a transformer.
  • the chip can read and store a current or voltage value from each electrode.
  • an antenna may be bonded to allow the electrochemical sensor tag to communicate with an external device (eg, a smart phone), and a value measured from the electrode may be provided to the outside through a chip.
  • FIG. 9 is a plan view showing an electrochemical sensor tag connected to a chip according to an embodiment of the present invention.
  • a part 350 of a connection part CON of a conductive wire on which the insulating layer 400 is not printed may be connected to the chip 500. Accordingly, values collected from the electrochemical sensor tag may be transmitted to the outside.
  • FIG. 10 is a graph showing different potentials according to pH of an electrochemical sensor tag manufactured according to an embodiment of the present invention, and a graph showing a voltage change according to a continuous pH change.
  • the electrochemical sensor tag manufactured according to the present invention outputs a linearly decreasing potential value as the pH (eg, within the range of pH 7 to 11) increases.
  • FIG. 10B it can be seen that even when the environment in which the pH is continuously changed continues for several hours, different output voltage values according to the pH are stably output.
  • an additional surface addition process may be performed on the working electrode, and the corresponding material can be identified from the value of a potential or current for each material.
  • FIG. 12 is a diagram showing a state in which a printed antenna and a chip are bonded to a completed electrochemical sensor tag to communicate with a smart phone.
  • Figure 12 (a) is a prototype of a smart phone reading the corresponding pH (or glucose, Cu 2+ , caffeine, etc.) value in real time using an NFC function from an actual printed electrochemical sensor tag.
  • 12(b) is a conceptual diagram showing a process of attaching an electrochemical sensor tag according to the present invention to a human body to transmit various values including pH to a smart phone.
  • the electrochemical sensor tag proposed in the present invention may be attached to the wrist in a non-blood collection form to check the user's pH or glucose concentration in real time.

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Abstract

L'invention concerne un procédé de fabrication d'une étiquette de capteur électrochimique à l'aide d'un protocole d'impression par gravure rouleau à rouleau (R2R) qui comprend les étapes consistant à : imprimer des premier à troisième fils conducteurs espacés les uns des autres sur un substrat de film de PET flexible à l'aide d'une encre de nanoparticules d'Ag hydrophobe ; imprimer un premier motif d'électrode sur au moins une partie du premier fil conducteur et du troisième fil conducteur à l'aide d'une encre de carbone conductrice ; et imprimer un deuxième motif d'électrode sur au moins une partie du deuxième fil conducteur à l'aide d'une encre Ag/AgCl, les premier au troisième fils conducteurs étant une électrode auxiliaire, une électrode de référence et une électrode de travail respectivement et formant un système à trois électrodes.
PCT/KR2019/001598 2019-02-08 2019-02-11 Procédé de fabrication d'une étiquette de capteur électrochimique au moyen d'un procédé d'impression par gravure r2r WO2020162650A1 (fr)

Applications Claiming Priority (2)

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KR10-2019-0015004 2019-02-08
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