WO2018109246A1 - Dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques - Google Patents

Dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques Download PDF

Info

Publication number
WO2018109246A1
WO2018109246A1 PCT/ES2017/070768 ES2017070768W WO2018109246A1 WO 2018109246 A1 WO2018109246 A1 WO 2018109246A1 ES 2017070768 W ES2017070768 W ES 2017070768W WO 2018109246 A1 WO2018109246 A1 WO 2018109246A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
piston
buoy
separated
fluid
Prior art date
Application number
PCT/ES2017/070768
Other languages
English (en)
Spanish (es)
Inventor
Guillermo GARAU ESPINÓS
Original Assignee
Garau Espinos Guillermo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US16/468,131 priority Critical patent/US11071690B2/en
Application filed by Garau Espinos Guillermo filed Critical Garau Espinos Guillermo
Priority to EP17881166.7A priority patent/EP3556292B1/fr
Priority to CA3045894A priority patent/CA3045894C/fr
Priority to ES17881166T priority patent/ES2879837T3/es
Priority to RU2019118386A priority patent/RU2718314C1/ru
Publication of WO2018109246A1 publication Critical patent/WO2018109246A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Definitions

  • the object of the present invention is a closed and sterile device for the separation and aseptic concentration of biological components, such as blood, plasma, adipose tissue, cells or any other.
  • This invention has characteristics oriented to allow researchers, scientists, biologists, doctors and veterinarians, to separate and concentrate different liquids, tissues or body fluids aseptically in a closed device by means of density gradients and / or differential centrifugation, to then be analyzed , studied and applied "in vitro” and "in vivo” without problems of external / environmental contamination by pathogens, bacteria, etc.
  • the closed and sterile device for the separation and aseptic concentration of biological components object of the invention, has technical characteristics aimed at solving the aforementioned problems and allowing permeability inside a separation tube through a valve mounted on a plunger of closing of the interior of the tube, without risks of contamination and safety for the user.
  • the device comprises at least: - a tube, closed at a first end and having a mouth at a second end;
  • a piston of flexible material without a drive rod, mounted inside the tube with the possibility of longitudinal displacement and that has a loading and unloading orifice of a fluid to be concentrated and separated into various fractions, whose orifice is provided with a luer-lock valve female connection; and of a conduit, provided with a self-sealing filter, through which automatic purging of the air / gas contained in the tube is performed during the filling of the tube with the fluid to be separated and concentrated and,
  • connection / piston assembly attachable to the mouth of the tube.
  • the piston provided with the female luer-lock valve connection allows, by coupling a syringe with male luer-lock connection, to load the blood or liquid to be treated and the subsequent extraction of the fractions obtained after centrifugation through of the piston and of the mentioned female luer-lock valve valve connection; performing said operations, in a safe, fast and reliable manner, as many times as necessary, without uncovering the tube and without using needles or other elements to pierce the plunger, avoiding contamination of the inside of the tube.
  • the plunger has a concave anterior end provided with radial fins to avoid turbulence and favor precise fractionation, controlling fluid dynamics and stabilizing the passage of the separated liquid fraction from inside the cylinder to a syringe of extraction coupled to the plunger connection.
  • Said piston has a lateral surface with a defined perimeter recess between adjusting rings that guarantee a good seal inside the tube and avoid excessive friction of the piston with the tube.
  • this device does not use needles, avoiding risks for the user and risks of contamination.
  • Another advantage of this device is that the female luer-lock connection coupled to the piston does not have dead spaces in its outer part where significant fractions of the introduced or removed fluids may be retained, which would be exposed to contamination.
  • the protective cap incorporates an absorbent filler inside that protects and externally dries the female luer-lock connection of possible drops of the fluids to be separated and concentrated, and provides permeability to the environment, avoiding contamination risks.
  • This plug provides a protection of the connection / plunger assembly preventing its contamination, preventing its eventual contact with any object during the manipulation of the tube by the user, and its contact with the suspended particles displaced by the air currents that occur during the centrifugation of the tube contents.
  • the device comprises inside the tube a cylindrical buoy, of a predetermined density, of a diameter suitable to the diameter of the inside of the tube and provided with a central hole with a unidirectional valve for the passage of the fractions denser towards the area located by under the buoy and thus float on a denser fraction, although the starting position of the buoy is the lower end of the tube, and said buoy is very tight to the walls of the tube, but without being locked in it; enough to slide and to remain stable without oscillations.
  • Said buoy is intended to be positioned by flotation between the fractions obtained after a centrifugation of the fluid to be separated forming a physical barrier between fractions of different density, floating above the denser fractions than itself.
  • said buoy has a concave upper face that ends at the central hole of fluid passage through the buoy.
  • This device is designed to be used in centrifugal equipment that has the appropriate size to be able to introduce it inside and have software that, depending on the objective, can be separated and concentrated in a flexible way that fluid (e.g. in the case of blood) more or less concentrated fractions can be removed, of greater or lesser volume.
  • Figure 1 shows an elevational view of an embodiment example of the closed and sterile device for the separation of aseptic concentration of biological components, with the cap in the open position.
  • FIG. 3 shows an elevation view of the device of the previous figures during the loading of the fluid to be separated inside the tube by means of a loading syringe provided with a male “luerlock” connection, complementary to the “luer” connection. lock “female piston valve, and coupled with it.
  • FIG. 5 shows a view of the device of the previous figures during the extraction of one of the liquid fractions by means of an extraction syringe coupled to the luer-lock connection of the plunger, and establishing said piston contact, by means of its perimeter lip , with the perimeter chamfer of the buoy.
  • the closed and sterile device for the separation and aseptic concentration of biological components comprises a tube (1) with a first end (1 1) closed and having a mouth (12) at a second end.
  • Said plunger (2) has an orifice (21) for loading a fluid to be separated and concentrated in various fractions, and for discharging the fractions of said fluid, of different density, separated by centrifugation.
  • the orifice (21) has at the end oriented towards the mouth (12) of the tube (1) of a female luer-lock connection (22), whose valve is normally held in a closed position and opens when coupled with a luer-lock male connection (CM).
  • CM luer-lock male connection
  • the piston (2) also has a conduit (23) for automatic purging of the air / gas contained in the tube (1) during the filling of the tube (1) with the fluid to be separated and concentrated, this filling operation being carried out by means of a loading syringe (JC) provided with a male "luerlock” connection (CM) complementary to that of the piston (2), as shown in Figure 3.
  • JC loading syringe
  • CM male "luerlock” connection
  • Said purge conduit (23) is provided with a self-sealing filter (24) comprising a gelling filler which, when in contact with the fluid to be separated due to the complete filling of the tube (1) and is moistened with said fluid, gels and Seals immediately, losing its permeability to air / gas and liquids.
  • a self-sealing filter (24) comprising a gelling filler which, when in contact with the fluid to be separated due to the complete filling of the tube (1) and is moistened with said fluid, gels and Seals immediately, losing its permeability to air / gas and liquids.
  • the piston (2) has a concave anterior end (25), oriented towards the first end (11) of the tube (1) and provided with radial fins (25), which avoid turbulence and favor precise fractionation, stabilizing the passage of the liquid fraction separated from inside the tube (1) to an extraction syringe (JE) coupled to the female "luer-lock” connection (22) valved from the plunger (2) by means of a male "luer-lock” connection (CM) complementary, as shown in Figure 5.
  • This extraction syringe (JE) has a smaller diameter than the tube (1) acting in the coupling position as the piston rod (2).
  • the piston has on its side surface a perimeter recess (27) defined between adjusting rings (28) with the inside of the tube (1).
  • the device comprises a protection plug (3) of the connection / piston assembly, attachable to the mouth (12) of the tube (1).
  • This protective cap (3) incorporates in its interior an absorbent filler (31) that protects and dries the female luer-lock connection (22) of the piston (2) from possible drops of the fluids to be separated and concentrated, avoiding contamination risks .
  • Said buoy (4) has a concave upper face (43) that ends, internally, in the central hole (41) of fluid passage through the buoy (2) and, externally, in a perimeter chamfer (44).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques, qui comprend, au moins : - un tube (1) fermé par une première extrémité (11) et qui comprend une ouverture (12) sur une deuxième extrémité ; - un piston (2) constitué d'un matériau flexible, sans tige d'actionnement, monté à l'intérieur du tube (1) avec la possibilité de se déplacer dans le sens longitudinal et qui comprend un orifice (21) de charge d'un fluide à séparer et à concentrer, et de décharge des fractions séparées, ledit orifice (21) étant pourvu d'un raccord (22) Luer-Lock femelle à valve ; et un conduit (23) d'évacuation, pourvu d'un filtre auto-obturant (24) pour l'évacuation automatique de l'air/gaz présent dans le tube (1) pendant le remplissage du tube (1) avec le fluide à séparer et concentrer ; et - un bouchon (3) de protection de l'ensemble raccord/piston, pouvant être couplé à l'ouverture du tube.
PCT/ES2017/070768 2016-12-16 2017-11-22 Dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques WO2018109246A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US16/468,131 US11071690B2 (en) 2016-12-16 2017-11-20 Sealed sterile device for the aseptic separation and concentration of biological components
EP17881166.7A EP3556292B1 (fr) 2016-12-16 2017-11-22 Dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques
CA3045894A CA3045894C (fr) 2016-12-16 2017-11-22 Dispositif sterile scelle pour la separation et la concentration aseptiques d'elements biologiques
ES17881166T ES2879837T3 (es) 2016-12-16 2017-11-22 Dispositivo cerrado y estéril para la separación y concentración aséptica de componentes biológicos
RU2019118386A RU2718314C1 (ru) 2016-12-16 2017-11-22 Герметично уплотненное устройство для асептического разделения и концентрации биологических компонентов

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201631598A ES2675279B2 (es) 2016-12-16 2016-12-16 Dispositivo cerrado y estéril para la separación y concentración aséptica de componentes biológicos
ESP201631598 2016-12-16

Publications (1)

Publication Number Publication Date
WO2018109246A1 true WO2018109246A1 (fr) 2018-06-21

Family

ID=62558091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2017/070768 WO2018109246A1 (fr) 2016-12-16 2017-11-22 Dispositif fermé et stérile pour la séparation et la concentration aseptiques de composants biologiques

Country Status (7)

Country Link
US (1) US11071690B2 (fr)
EP (1) EP3556292B1 (fr)
CA (1) CA3045894C (fr)
ES (2) ES2675279B2 (fr)
PT (1) PT3556292T (fr)
RU (1) RU2718314C1 (fr)
WO (1) WO2018109246A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114025878A (zh) * 2019-06-26 2022-02-08 萨斯特德特股份有限两合公司 用于封闭用来容纳液体的试样小管的封闭盖

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849052B2 (en) * 1999-12-13 2005-02-01 Arkray, Inc. Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus
ES1059764U (es) 2005-03-07 2005-06-01 M. Dolores Espinos Fabo Dispositivo para la separacion y recuperacion de fluidos en medicina.
EP2077115A1 (fr) * 2006-10-27 2009-07-08 Nipro Corporation Séparateur de plasma riche en plaquettes et procédé de séparation de plasma riche en plaquettes
US20110083978A1 (en) * 2009-10-13 2011-04-14 Cytomedix, Inc. Kit for separation of biological fluids
ES2437541B1 (es) 2012-07-03 2014-11-25 Biotechnology Institute, I Mas D, S.L. Dispositivo para la extracción, el almacenamiento y/o el procesado de sangre u otras sustancias de origen humano o animal, y para la aplicación de compuestos sanguíneos u otros compuestos biológicos
US20140358033A1 (en) * 1998-05-29 2014-12-04 Lawrence A. Lynn Luer Receiving Air Evacuated Blood Collector

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735900A (en) * 1971-05-13 1973-05-29 Prod Res & Chem Corp Dual ingredient storage, intermixing and dispensing storage
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
US4936315A (en) * 1988-10-20 1990-06-26 Lineback Paul I Methods and apparatus for obtaining arterial blood samples
US7179391B2 (en) * 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US8425239B2 (en) * 2009-07-09 2013-04-23 Tyco Electronics Corporation Electrical connector for a solar module assembly
US9804070B2 (en) * 2013-03-26 2017-10-31 Alliance Partners, Llc Biological fluids concentration assembly

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140358033A1 (en) * 1998-05-29 2014-12-04 Lawrence A. Lynn Luer Receiving Air Evacuated Blood Collector
US6849052B2 (en) * 1999-12-13 2005-02-01 Arkray, Inc. Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus
ES1059764U (es) 2005-03-07 2005-06-01 M. Dolores Espinos Fabo Dispositivo para la separacion y recuperacion de fluidos en medicina.
EP2077115A1 (fr) * 2006-10-27 2009-07-08 Nipro Corporation Séparateur de plasma riche en plaquettes et procédé de séparation de plasma riche en plaquettes
US20110083978A1 (en) * 2009-10-13 2011-04-14 Cytomedix, Inc. Kit for separation of biological fluids
ES2437541B1 (es) 2012-07-03 2014-11-25 Biotechnology Institute, I Mas D, S.L. Dispositivo para la extracción, el almacenamiento y/o el procesado de sangre u otras sustancias de origen humano o animal, y para la aplicación de compuestos sanguíneos u otros compuestos biológicos

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114025878A (zh) * 2019-06-26 2022-02-08 萨斯特德特股份有限两合公司 用于封闭用来容纳液体的试样小管的封闭盖
CN114025878B (zh) * 2019-06-26 2023-07-04 萨斯特德特股份有限两合公司 用于封闭用来容纳液体的试样小管的封闭盖

Also Published As

Publication number Publication date
RU2718314C1 (ru) 2020-04-01
ES2879837T3 (es) 2021-11-23
US20200069521A1 (en) 2020-03-05
ES2675279A1 (es) 2018-07-10
ES2675279B2 (es) 2018-12-21
EP3556292A4 (fr) 2020-05-13
EP3556292A1 (fr) 2019-10-23
PT3556292T (pt) 2021-06-23
CA3045894A1 (fr) 2018-06-21
US11071690B2 (en) 2021-07-27
CA3045894C (fr) 2023-10-31
EP3556292B1 (fr) 2021-04-07

Similar Documents

Publication Publication Date Title
ES2379121T3 (es) Dispositivo de compensación de presión por acceso a vial.
ES2289306T3 (es) Aparato y procedimiento para la separacion de plaquetas sanguineas.
ES2598628T3 (es) Dispensador aséptico
JP6318231B2 (ja) 非ベント型バイアル・アクセス・シリンジ
ES2938844T3 (es) Tapa de acceso al vial y jeringa con válvula asistida por gravedad
ES2354440T3 (es) Dispositivo desechable para una o más introducciones, tratamiento y toma de muestras de material biológico procedente de al menos una de las fases separadas presentes en el dispositivo, en condiciones de esterilidad y presión constante.
ES2361354T3 (es) Adaptador de vial con ventilación con filtro para retención de aerosol.
ES2372492T3 (es) Método y aparato para separar componentes de fluido.
ES2568265T3 (es) Adaptadores de vial y viales para regular la presión
US8241592B2 (en) Cell separation method and apparatus
ES2711169T3 (es) Ampolla para un líquido médico y procedimiento para la fabricación de una ampolla
ES2585006T3 (es) Sistema móvil para separar mediante gravedad sangre de donante
ES2832754T3 (es) Dispositivo contenedor para la recolección, el almacenamiento y el procesado de sangre o de un compuesto sanguíneo
BRPI0619029A2 (pt) método para processamento de um fluido biológico, método para processamento de um fluido biológico contendo leucócitos, aparelho de filtração de fluido passìvel de pré-carga, sistema de processamento de fluido biológico de tipo sem respiro, método de processamento de um fluido biológico mediante utilização de um sistema de processamento, sistema de processamento de fluido desprovido de respiro e passìvel de pré- carga, método de processamento de um fluido mediante utilização de um sistema de processamento, e método de processamento de sangue mediante utilização de um sistema processamento
JP2018500097A (ja) 流体薬剤成分を混合及び分注するための容器
ES2879837T3 (es) Dispositivo cerrado y estéril para la separación y concentración aséptica de componentes biológicos
US20150328388A1 (en) Device for separating/housing blood components and method for preparing platelet-rich plasma
ES2360593T3 (es) Recipiente equipado con un sistema de transferencia aséptica.
ES2828254T3 (es) Método para la separación de fases de una mezcla líquida y la posterior separación de un sobrenadante líquido y separador de fases para el método
BR112014011598B1 (pt) dispositivo de interfaceamento destinado a colocar em ligação um instrumento de injeção de um fluido e um frasco a perfurar
US20160243165A1 (en) Processing cell therapy products
ES2712987T3 (es) Sistema de bolsa de sangre estéril para la extracción médica y conservación criogénica de sangre de cordón umbilical
JP7303220B2 (ja) バイアルアダプター
WO2023172119A1 (fr) Ensemble fiole et bouchon-poinçon pour prolonger la durée de conservation d'un vaccin et/ou médicament

Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17881166

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 3045894

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2017881166

Country of ref document: EP

Effective date: 20190716