WO2018087129A1 - Marqueurs de méthylation du cancer colorectal - Google Patents

Marqueurs de méthylation du cancer colorectal Download PDF

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Publication number
WO2018087129A1
WO2018087129A1 PCT/EP2017/078573 EP2017078573W WO2018087129A1 WO 2018087129 A1 WO2018087129 A1 WO 2018087129A1 EP 2017078573 W EP2017078573 W EP 2017078573W WO 2018087129 A1 WO2018087129 A1 WO 2018087129A1
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Prior art keywords
colorectal cancer
methylation
group
alx4
sept9
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PCT/EP2017/078573
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English (en)
Inventor
Ole THORLACIUS-USSING
Simon LADEFOGED RASMUSSEN
Henrik BYGUM KRARUP
Poul Henning MADSEN
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Region Nordjylland, Aalborg University Hospital
Aalborg Universitet
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Publication of WO2018087129A1 publication Critical patent/WO2018087129A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une méthode permettant de déterminer un cancer colorectal, ou le pronostic d'un cancer colorectal chez un sujet, ladite méthode consistant à déterminer, dans un échantillon provenant dudit sujet, l'état de méthylation d'un panel de marqueurs d'un gène spécifique.
PCT/EP2017/078573 2016-11-08 2017-11-08 Marqueurs de méthylation du cancer colorectal WO2018087129A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16197722.8 2016-11-08
EP16197722 2016-11-08

Publications (1)

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WO2018087129A1 true WO2018087129A1 (fr) 2018-05-17

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PCT/EP2017/078573 WO2018087129A1 (fr) 2016-11-08 2017-11-08 Marqueurs de méthylation du cancer colorectal

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WO (1) WO2018087129A1 (fr)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108796080A (zh) * 2018-06-06 2018-11-13 苏州唯善生物科技有限公司 用于结直肠癌诊断、检测或筛查的引物和探针组
CN110699437A (zh) * 2019-11-11 2020-01-17 益善生物技术股份有限公司 人sdc2基因甲基化检测试剂盒
WO2020081549A1 (fr) * 2018-10-15 2020-04-23 The Regents Of The University Of California Procédés et matériels pour évaluer et traiter le cancer
CN111560435A (zh) * 2020-05-20 2020-08-21 深圳市新合生物医疗科技有限公司 一种用于结直肠癌检测的dna甲基化试剂盒及使用方法、应用
CN112063712A (zh) * 2019-10-28 2020-12-11 北京康美天鸿生物科技有限公司 基于高分辨率熔解曲线检测septin9基因甲基化的特异引物对和试剂盒
WO2021004215A1 (fr) * 2019-07-11 2021-01-14 广州市康立明生物科技有限责任公司 Réactif de détection combiné multigénique
KR20210044923A (ko) * 2019-10-15 2021-04-26 사회복지법인 삼성생명공익재단 대장암 진단을 위한 대장암 특이적 메틸화 바이오마커
CN112752763A (zh) * 2018-05-23 2021-05-04 杭州诺辉健康科技有限公司 筛查结直肠癌和晚期腺瘤的试剂盒及其应用
KR20210055281A (ko) * 2019-11-07 2021-05-17 (주)지노믹트리 대장암 검출 방법
CN113403393A (zh) * 2021-05-06 2021-09-17 江苏为真生物医药技术股份有限公司 一种癌症和/或癌前病变检测试剂盒
WO2021209161A1 (fr) * 2020-04-17 2021-10-21 Universal Diagnostics, S.L. Détection d'un adénome avancé et/ou d'un cancer colorectal de stade précoce
EP3792362A4 (fr) * 2018-01-23 2021-11-17 Excellen Medical Technology Co., Ltd. Méthode et kit pour identifier l'état d'un cancer colorectal
WO2022002424A1 (fr) * 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systèmes et procédés de détection de plusieurs types de cancer
WO2022139581A1 (fr) * 2020-12-24 2022-06-30 Stichting Vumc Détection de marqueurs d'acide nucléique dans l'urine à l'aide d'une analyse de méthylation de l'adn
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US20220267859A1 (en) * 2019-07-22 2022-08-25 Wuhan Ammunition Life-Tech Co., Ltd. Use of detection reagent for detecting methylation of genes associated with colorectal cancer, and kit
WO2022222146A1 (fr) * 2021-04-23 2022-10-27 华大数极生物科技(深圳)有限公司 Composition, kit et application pour la détection du cancer colorectal
EP3963095A4 (fr) * 2019-05-03 2023-01-25 Cornell University Marqueurs pour l'identification et la quantification d'une mutation, d'une expression, d'un variant d'épissage, d'une translocation, d'un nombre de copies ou de changements de méthylation de séquence d'acides nucléiques
US11821045B2 (en) 2021-04-13 2023-11-21 Geninus Inc. Colorectal cancer-specific methylation biomarkers for diagnosing colorectal cancer
CN117551762A (zh) * 2023-10-19 2024-02-13 嘉兴允英医学检验有限公司 作为结直肠肿瘤标志物的dna甲基化位点组合及其应用
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN117551762B (zh) * 2023-10-19 2024-05-10 嘉兴允英医学检验有限公司 作为结直肠肿瘤标志物的dna甲基化位点组合及其应用

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WO2007118704A2 (fr) * 2006-04-17 2007-10-25 Epigenomics Ag Procédés et acides nucléiques pour détecter des troubles de prolifération de cellules colorectales
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WO2007118704A2 (fr) * 2006-04-17 2007-10-25 Epigenomics Ag Procédés et acides nucléiques pour détecter des troubles de prolifération de cellules colorectales
US20160251727A1 (en) * 2015-02-27 2016-09-01 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms

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BOCK ET AL., NATURE BIOTECH., vol. 34, no. 7, 2016
JORJA D WARREN ET AL: "Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer", BMC MEDICINE, BIOMED CENTRAL LTD., LONDON, GB, vol. 9, no. 1, 14 December 2011 (2011-12-14), pages 133, XP021131493, ISSN: 1741-7015, DOI: 10.1186/1741-7015-9-133 *
MANIATIS ET AL.: "Molecular Cloning: A Laboratory Manual", 1982, COLD SPRING HARBOR, pages: 280,281
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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3792362A4 (fr) * 2018-01-23 2021-11-17 Excellen Medical Technology Co., Ltd. Méthode et kit pour identifier l'état d'un cancer colorectal
CN112752763A (zh) * 2018-05-23 2021-05-04 杭州诺辉健康科技有限公司 筛查结直肠癌和晚期腺瘤的试剂盒及其应用
EP3797112A4 (fr) * 2018-05-23 2022-03-23 Hangzhou New Horizon Health Technology Co., Ltd. Kit de dépistage du cancer colorectal et d'adénome avancé et son application
WO2019233102A1 (fr) * 2018-06-06 2019-12-12 苏州唯善生物科技有限公司 Ensemble d'amorce et de sonde pour le diagnostic, la détection, ou le criblage du cancer colorectal
CN108796080A (zh) * 2018-06-06 2018-11-13 苏州唯善生物科技有限公司 用于结直肠癌诊断、检测或筛查的引物和探针组
CN108796080B (zh) * 2018-06-06 2022-06-07 苏州唯善生物科技有限公司 用于结直肠癌诊断、检测或筛查的引物和探针组
WO2020081549A1 (fr) * 2018-10-15 2020-04-23 The Regents Of The University Of California Procédés et matériels pour évaluer et traiter le cancer
EP3963095A4 (fr) * 2019-05-03 2023-01-25 Cornell University Marqueurs pour l'identification et la quantification d'une mutation, d'une expression, d'un variant d'épissage, d'une translocation, d'un nombre de copies ou de changements de méthylation de séquence d'acides nucléiques
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
WO2021004215A1 (fr) * 2019-07-11 2021-01-14 广州市康立明生物科技有限责任公司 Réactif de détection combiné multigénique
US11767565B2 (en) * 2019-07-22 2023-09-26 Wuhan Ammunition Life-Tech Co., Ltd. Use of detection reagent for detecting methylation of genes associated with colorectal cancer, and kit
US20220267859A1 (en) * 2019-07-22 2022-08-25 Wuhan Ammunition Life-Tech Co., Ltd. Use of detection reagent for detecting methylation of genes associated with colorectal cancer, and kit
KR102440245B1 (ko) * 2019-10-15 2022-09-07 사회복지법인 삼성생명공익재단 대장암 진단을 위한 대장암 특이적 메틸화 바이오마커
KR20210044923A (ko) * 2019-10-15 2021-04-26 사회복지법인 삼성생명공익재단 대장암 진단을 위한 대장암 특이적 메틸화 바이오마커
CN112063712A (zh) * 2019-10-28 2020-12-11 北京康美天鸿生物科技有限公司 基于高分辨率熔解曲线检测septin9基因甲基化的特异引物对和试剂盒
KR20210055281A (ko) * 2019-11-07 2021-05-17 (주)지노믹트리 대장암 검출 방법
KR102261606B1 (ko) * 2019-11-07 2021-06-07 (주)지노믹트리 대장암 검출 방법
CN110699437A (zh) * 2019-11-11 2020-01-17 益善生物技术股份有限公司 人sdc2基因甲基化检测试剂盒
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
WO2021209161A1 (fr) * 2020-04-17 2021-10-21 Universal Diagnostics, S.L. Détection d'un adénome avancé et/ou d'un cancer colorectal de stade précoce
CN111560435A (zh) * 2020-05-20 2020-08-21 深圳市新合生物医疗科技有限公司 一种用于结直肠癌检测的dna甲基化试剂盒及使用方法、应用
WO2022002424A1 (fr) * 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systèmes et procédés de détection de plusieurs types de cancer
US11530453B2 (en) 2020-06-30 2022-12-20 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
NL2027228B1 (en) * 2020-12-24 2022-07-20 Stichting Vumc Detection of nucleic acid markers in urine using DNA methylation analysis
WO2022139581A1 (fr) * 2020-12-24 2022-06-30 Stichting Vumc Détection de marqueurs d'acide nucléique dans l'urine à l'aide d'une analyse de méthylation de l'adn
US11821045B2 (en) 2021-04-13 2023-11-21 Geninus Inc. Colorectal cancer-specific methylation biomarkers for diagnosing colorectal cancer
WO2022222146A1 (fr) * 2021-04-23 2022-10-27 华大数极生物科技(深圳)有限公司 Composition, kit et application pour la détection du cancer colorectal
CN113403393A (zh) * 2021-05-06 2021-09-17 江苏为真生物医药技术股份有限公司 一种癌症和/或癌前病变检测试剂盒
CN117551762A (zh) * 2023-10-19 2024-02-13 嘉兴允英医学检验有限公司 作为结直肠肿瘤标志物的dna甲基化位点组合及其应用
CN117551762B (zh) * 2023-10-19 2024-05-10 嘉兴允英医学检验有限公司 作为结直肠肿瘤标志物的dna甲基化位点组合及其应用

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