WO2018077122A1 - Positioning device and method for automatic medicine dispensing system - Google Patents

Positioning device and method for automatic medicine dispensing system Download PDF

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Publication number
WO2018077122A1
WO2018077122A1 PCT/CN2017/107125 CN2017107125W WO2018077122A1 WO 2018077122 A1 WO2018077122 A1 WO 2018077122A1 CN 2017107125 W CN2017107125 W CN 2017107125W WO 2018077122 A1 WO2018077122 A1 WO 2018077122A1
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needle
image
positioning
coordinates
positioning device
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PCT/CN2017/107125
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French (fr)
Chinese (zh)
Inventor
郑永强
柏轲
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成都杰仕德科技有限公司
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Publication of WO2018077122A1 publication Critical patent/WO2018077122A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting

Definitions

  • the present invention relates to the field of electronic technology, and in particular, to a positioning apparatus and method for an automatic dispensing system.
  • the operation procedure is as follows: Before dispensing, the operator is ready to be equipped with drugs and medicines (ampoules, vials, infusion bags, syringes, etc.); Relevant medicines and medicines information; open medicine containers (ampoules, vials, infusion bags, syringes, etc.); disinfection of contact parts (mainly for ampoule, vials, infusion bags); manual use of syringes for drug suction; Inject the drug into the infusion bag or infusion bottle; fill in the record card and put the infusion bag into the infusion bag storage basket.
  • drugs and medicines ampoules, vials, infusion bags, syringes, etc.
  • Relevant medicines and medicines information mainly for ampoule, vials, infusion bags
  • disinfection of contact parts mainly for ampoule, vials, infusion bags
  • manual use of syringes for drug suction Inject the drug into the infusion bag or infusion bottle; fill in the record card and put the
  • the automatic dispensing robot system disclosed in the invention patent application CN 103006436 A or other automatic dispensing system or method generally requires when the medicine in the medicine container needs to be input into the mother liquid or the mother liquid is input into the medicine container. Insert the syringe needle attached to the end of the catheter into the drug container. However, after the needle is mounted on the fixed bracket, it will have a certain curvature and/or inclination angle, which is not a completely vertical straight shape. Such misalignment of the needle and the drug container may cause the needle to deviate from the preset communication position in the medicine container or cannot Insertion of the drug container, there are technical problems such as low dispensing efficiency and high failure rate of dispensing.
  • At least one of the objects of the present invention is to provide a positioning apparatus and method for an automatic dispensing system that enables the needle to be accurately aligned with a predetermined insertion position of the medicine container, thereby improving the dispensing success. Rate and dispensing efficiency.
  • a positioning device for an automatic dispensing system comprising a bracket, a liquid injection component, a clamping component, a camera and a control module; wherein the liquid injection component is movably disposed on the first screw, the clamping component is movable Placed on the second screw rod, the first screw rod and the second screw rod are arranged in parallel on the bracket;
  • the camera is fixedly disposed at a bottom of the bracket for acquiring a needle positioning image taken from a lower vertical direction;
  • the control module is configured to perform grayscale processing on the acquired needle positioning image to obtain a binary image; acquire coordinates of the end point of the needle according to the binary image; according to the coordinates of the end point of the needle and the preset camera and the needle mount a distance compensation command is generated between the distances;
  • the clamping component and the liquid injection component are configured to perform relative displacement according to the displacement compensation command to implement displacement compensation.
  • the camera is fixedly disposed directly below the second pin station for being used after the liquid injecting component drives the needle to reach the first pinning station, and before the clamping component does not reach the second pinning station, The needle fixed to the needle holder is photographed from the bottom vertically upward to obtain a needle positioning image.
  • the camera is fixedly disposed between the second pin station and the front surface of the bracket, and is used for shooting from the bottom vertical upward when the liquid injection component drives the needle over the camera and the clamping component is not in the same horizontal position.
  • the needle on the needle mount acquires the needle positioning image and converts the coordinates of the obtained needle positioning image according to the horizontal distance between the camera and the second pin station.
  • control module is configured to acquire an edge pattern according to the binary image, and determine coordinates of the end point of the needle according to the edge image.
  • the above control module is configured to identify the needle representing the needle from the binary image by Hough transform A straight line that determines the coordinates of the endpoint of the needle through the endpoints of the line.
  • the clamping member is configured to move in the first direction according to the shift compensation command; or the liquid injecting member is configured to move in a direction opposite to the first direction according to the shift compensation command.
  • the clamping member is configured to move the medicine container in the second direction by the left and right jaws, the second direction being perpendicular to the first direction.
  • control module is configured to perform smoothing on the binary image by using a Gaussian filter, obtain a binarized edge pattern by using a second-order central moment operator, and determine a needle from the binarized edge pattern according to a preset gray value range.
  • the image area determines the coordinates of the endpoint of the needle based on the area of the needle image.
  • a positioning method for an automatic dispensing system which uses the above-mentioned positioning device to realize displacement compensation by: acquiring a needle positioning image taken from a lower vertical direction; performing grayscale processing on the needle positioning image to obtain a binary image; The binary image acquires the coordinates of the end point of the needle; the displacement compensation command is generated according to the coordinates of the end point and the distance between the preset camera and the needle mount; the clamping component and the liquid injection component are relatively moved according to the displacement compensation command to realize displacement compensation. .
  • the present invention has at least the following beneficial effects:
  • the coordinates of the end point of the needle are obtained by the needle positioning image, and the displacement compensation is performed according to the coordinates of the end point of the needle, so that the needle can be accurately aligned with the preset insertion position of the medicine container, so that the medicine container can be accurately and quickly inserted from the preset position. Therefore, the success rate of dispensing and the efficiency of dispensing are improved.
  • FIG. 1 is a schematic structural view of a positioning device for an automatic dispensing system according to an embodiment of the present invention
  • FIG. 2 is a schematic structural view of a liquid injection component in a positioning device for an automatic dispensing system according to an embodiment of the present invention
  • FIG. 3 is a schematic structural view of a clamping member in a positioning device for an automatic dispensing system according to an embodiment of the present invention
  • FIG. 4A is a schematic diagram of a needle positioning image in a positioning device for an automatic dispensing system according to an embodiment of the present invention
  • 4B is a schematic diagram of a binarized edge pattern according to an embodiment of the present invention.
  • FIG. 5 is a flow chart of a positioning method for an automatic dispensing system according to an embodiment of the present invention.
  • a positioning device for an automatic dispensing system includes a bracket 1, a clamping member 2, a liquid injection component 6, a camera S1, and a control module C1, wherein:
  • the liquid injection member 6 is movably disposed on the first screw rod 11, and the clamping member 2 is movably disposed on the second screw rod 12.
  • the first screw rod 11 and the second screw rod 12 are disposed in parallel on the bracket 1.
  • the control module C1 may be disposed on the bracket 1 as shown in FIG. 1, or may be disposed on a separate bracket other than the bracket 1.
  • the control module C1 may include various image or arithmetic processors and realize wired connection with controlled devices such as respective motors, cameras S1, etc. through cables disposed along the groove of the bracket, or wirelessly with each controlled device through a wireless communication interface. connection.
  • the control module C1 can drive the liquid injection unit 6 from the holder 1 along the first screw rod 11 by controlling the first screw motor M1.
  • the front side moves to the first pin station (for example, the liquid member 6 is located in the YZ plane, and the center axis of the needle bayonet 69 coincides with the Z axis), and the clamping member 2 is driven by the second screw motor M2 to drive the clamped portion.
  • the medicine container 101 is moved along the second screw 12 from the front side of the holder 1 to the second pin station (for example, The central axis of the drug container 101 coincides with the Z axis), and the predetermined insertion position of the drug container 101 is located directly below the needle 62.
  • the elevating mechanism 68 provided on the liquid filling member 6 drives the needle 62 to move downward through the needle mount 69 and is inserted into the medicine container 101 to effect injection or suction of the medicine.
  • the camera S1 can be fixed at the bottom of the bracket 1 for acquiring a needle positioning image taken from the lower vertical direction, and the obtained needle positioning image can be generated to the control module C1 by wire or wirelessly.
  • the method of positioning by a positioning device for an automatic dispensing system as shown in FIG. 1 includes the following steps:
  • Step 501 Acquire a needle positioning image taken from the bottom vertical direction
  • the camera S1 can be fixedly disposed directly below the second pin station (for example, the position of the origin O), and when the liquid injecting member 6 drives the needle 62 to reach the first pin through the needle card slot 69. After the station, and before the gripping member 2 reaches the second pinning station, the needle 62 fixed to the needle mount 69 is photographed from the bottom vertically upward to obtain a needle positioning image.
  • the camera S1 may also be fixedly disposed in the negative direction of the X-axis (for example, between the second pin station and the front surface of the bracket 1).
  • the liquid-injecting member 6 drives the needle 62 through the needle S through the camera S1
  • the clamping member 2 is not in the same horizontal position
  • the needle 62 fixed on the needle mount 69 is taken from the bottom vertically upward to obtain the needle positioning image, and according to the level of the camera S1 and the second pin station (or the origin O) The distance is converted into the coordinate of the obtained needle positioning image to the origin with the origin O as the origin.
  • Step 502 Perform grayscale processing on the needle positioning image to obtain a binary image.
  • G0/K performs binarization conversion on the needle positioning image to obtain a binary image; wherein K is a positive integer greater than 1.
  • Step 503 Acquire coordinates of the endpoint N of the needle according to the binary image.
  • control module C1 can acquire the edge pattern according to the binary image, and determine the coordinates (Xn, Yn) of the end point N of the needle 62 in the needle positioning image according to the edge image.
  • control module C1 may recognize the straight line ON indicating the needle 62 from the binary image by Hough Transform, and determine the coordinates (Xn, Yn) of the end point N of the needle 62 by the end point of the straight line ON.
  • Step 504 Generate a displacement compensation instruction according to the coordinates of the endpoint and the distance between the preset camera S1 and the needle mount 69.
  • the control module C1 When the needle 62 is offset from its central axis (for example, the needle is deformed by bending, deflection, etc. during installation or movement), that is, when any of the coordinate values Xn and Yn is not zero, the control module C1 is preset according to the preset.
  • the distance between the camera S1 and the needle mount 69 determines the distance unit (for example, millimeters) of the coordinates, and generates a displacement compensation command based on the coordinates (Xn, Yn) of the end point N.
  • the displacement compensation command generated by the control module C1 is: the second screw motor M2 drives the clamping member 2 to drive the medicine container 101 along the second screw rod away from the bracket at a rotation speed of 400 rev/min.
  • the direction of the front side (the positive direction of the X axis) moves, and the moving distance is Xn mm; or, the first screw motor M1 drives the liquid injection part 6 to drive the needle holder 69 along the first screw rod toward the bracket at a rotation speed of 400 rev/min.
  • the front direction (X-axis negative direction) moves, and the moving distance is Xn mm.
  • the generated displacement compensation command is: the clamping motor M3 drives the left jaw 21 and the right jaw 22 in the clamping member 2 to drive the medicine container 101 along the clamping direction at a rotation speed of 400 rev/min. (Y-axis positive or negative direction) moves, the moving distance is Yn mm.
  • Step 505 The clamping member 2 and the liquid injection member 6 perform relative movement according to the displacement compensation command to realize displacement compensation.
  • the clamping member 2 moves along the direction in which the second screw rod is away from the front surface of the bracket, or the liquid injection member 6 moves in the direction of the first screw rod toward the front surface of the bracket; and/or, in the clamping member 2
  • the left jaw 21 and the right jaw 22 move the drug container 101 in the clamping direction, ultimately accurately aligning the needle 62 with the predetermined insertion position above the drug container 101.
  • the pins corresponding to the mother liquor container 102 or other types of pharmaceutical containers are mounted after the corresponding needle mounts, and displacement compensation can also be performed using the positioning apparatus and method of the present invention.
  • control module C1 determines that the coordinates (Xn, Yn) of the endpoint N of the needle in the needle positioning image according to the edge image may include: smoothing the binary image with a Gaussian filter having a standard deviation of 2, The second-order central moment operator is used to obtain the binarized edge graph. Wherein, the second-order central moment operator is the square mean of the gray values in the binary image.
  • FIG. 4B illustrates a binarized edge pattern according to an embodiment of the present invention, which includes three regions, and the bayonet image region A corresponding to the needle mount has a first gray value range (for example, 200 to 255), and The card end image area B corresponding to the needle card end 63 has a second gradation value range (for example, 100 to 200), and the needle image area C corresponding to the needle 62 has a third gradation value range (for example, 0 to 100). Further, the coordinates (Xn, Yn) of the end point N of the needle in the needle positioning image can be determined according to the coordinates of the point farthest from the origin O in the needle image region C.
  • the line segment or image representing the needle is acquired by the camera S1 from the needle positioning image taken from the lower vertical direction, thereby determining the coordinates of the end point of the needle, and the displacement compensation of the alignment position is performed according to the coordinates of the end point of the needle, so that the needle is accurate. Aligning the preset position of the medicine container, the needle can be accurately and quickly inserted into the medicine container from the preset position, thereby improving the medicine success rate and the dispensing efficiency.

Abstract

Disclosed are a positioning device and a method for an automatic medicine dispensing system. The method comprises the steps of: acquiring a needle positioning image vertically taken from bottom to top; performing grey-scale treatment on the needle positioning image to acquire a binary image; acquiring coordinates of an end point (N) of a needle (62) according to the binary image; generating a displacement compensation instruction according to the coordinates of the end point (N) and a pre-set distance between a camera (S1) and a needle bayonet (69); a clamping component (2) and a liquid injection component (6), according to the displacement compensation instruction, moving relative to each other to realize displacement compensation. The device and the method allow the needle (62) to accurately align to a pre-set insertion position of a medicine container (101), so as to accurately and quickly insert the needle into the medicine container (101) from the pre-set position, thus improving the medicine dispensing success rate and medicine dispensing efficiency.

Description

一种用于自动配药系统的定位装置和方法Positioning device and method for automatic dispensing system 技术领域Technical field
本发明涉及电子技术领域,尤其涉及一种用于自动配药系统的定位装置和方法。The present invention relates to the field of electronic technology, and in particular, to a positioning apparatus and method for an automatic dispensing system.
背景技术Background technique
目前,大多数医院的药物配置均由护士在配药房内完成,其操作流程如下:配药前,操作人员准备好待配药品及药具(安瓿瓶,西林瓶,输液袋,注射器等);检查相关药品及药具信息;开启药品容器(安瓿瓶,西林瓶,输液袋,注射器等);接触部位的消毒(主要针对安瓿瓶,西林瓶,输液袋);人工采用注射器进行药品抽吸;把药品注射进输液袋或输液瓶;填写记录卡并将已配输液袋放入输液袋存放篮。At present, most of the hospital's drug configuration is completed by the nurse in the dispensing room. The operation procedure is as follows: Before dispensing, the operator is ready to be equipped with drugs and medicines (ampoules, vials, infusion bags, syringes, etc.); Relevant medicines and medicines information; open medicine containers (ampoules, vials, infusion bags, syringes, etc.); disinfection of contact parts (mainly for ampoule, vials, infusion bags); manual use of syringes for drug suction; Inject the drug into the infusion bag or infusion bottle; fill in the record card and put the infusion bag into the infusion bag storage basket.
现有技术中,无论是发明专利申请CN 103006436 A号公开的自动配药机器人系统还是其他自动配药系统或方法,当需要将药品容器内的药品输入母液中或者将母液输入药品容器内时,通常需要将连接在导管末端的注射器针头插入药品容器。然而,针头安装在固定支架上之后会具有一定的弯曲弧度和/或倾斜角度,并非完全垂直的直线形状,针头与药品容器的此种错位会导致针头偏离药品容器内预设的连通位置或者无法插入药品容器,因此存在配药效率低以及导致配药失败率高等技术问题。In the prior art, the automatic dispensing robot system disclosed in the invention patent application CN 103006436 A or other automatic dispensing system or method generally requires when the medicine in the medicine container needs to be input into the mother liquid or the mother liquid is input into the medicine container. Insert the syringe needle attached to the end of the catheter into the drug container. However, after the needle is mounted on the fixed bracket, it will have a certain curvature and/or inclination angle, which is not a completely vertical straight shape. Such misalignment of the needle and the drug container may cause the needle to deviate from the preset communication position in the medicine container or cannot Insertion of the drug container, there are technical problems such as low dispensing efficiency and high failure rate of dispensing.
发明内容Summary of the invention
本发明的目的之一至少在于,针对上述现有技术存在的问题,提供一种用于自动配药系统的定位装置和方法,使针头能够精确地对准药品容器的预设插入位置,提高配药成功率和配药效率。At least one of the objects of the present invention is to provide a positioning apparatus and method for an automatic dispensing system that enables the needle to be accurately aligned with a predetermined insertion position of the medicine container, thereby improving the dispensing success. Rate and dispensing efficiency.
为了实现上述目的,本发明采用的技术方案为: In order to achieve the above object, the technical solution adopted by the present invention is:
一种用于自动配药系统的定位装置,包括支架、注液部件、夹持部件、摄像头以及控制模块;其中,所述注液部件可移动地设置在第一丝杆上,夹持部件可移动地设置在第二丝杆上,第一丝杆、第二丝杆平行设置在支架上;A positioning device for an automatic dispensing system, comprising a bracket, a liquid injection component, a clamping component, a camera and a control module; wherein the liquid injection component is movably disposed on the first screw, the clamping component is movable Placed on the second screw rod, the first screw rod and the second screw rod are arranged in parallel on the bracket;
所述摄像头,固定设置在支架的底部,用于获取自下垂直向上拍摄的针头定位图像;The camera is fixedly disposed at a bottom of the bracket for acquiring a needle positioning image taken from a lower vertical direction;
所述控制模块,用于对获取的针头定位图像进行灰度化处理,获取二值图像;根据二值图像获取针头的端点的坐标;根据针头的端点的坐标以及预设的摄像头与针头卡口之间的距离生成位移补偿指令;The control module is configured to perform grayscale processing on the acquired needle positioning image to obtain a binary image; acquire coordinates of the end point of the needle according to the binary image; according to the coordinates of the end point of the needle and the preset camera and the needle mount a distance compensation command is generated between the distances;
所述夹持部件和注液部件,用于根据位移补偿指令进行相对移动以实现位移补偿。The clamping component and the liquid injection component are configured to perform relative displacement according to the displacement compensation command to implement displacement compensation.
优选地,上述摄像头,固定设置在第二插针工位的正下方,用于当注液部件带动针头到达第一插针工位之后,且夹持部件未到达第二插针工位之前,自下垂直向上拍摄固定在针头卡口上的针头,获取针头定位图像。Preferably, the camera is fixedly disposed directly below the second pin station for being used after the liquid injecting component drives the needle to reach the first pinning station, and before the clamping component does not reach the second pinning station, The needle fixed to the needle holder is photographed from the bottom vertically upward to obtain a needle positioning image.
优选地,上述摄像头,固定设置在第二插针工位与支架的正面之间,用于当注液部件带动针头经过摄像头上方,且夹持部件不在相同水平位置时,自下垂直向上拍摄固定在针头卡口上的针头,获取针头定位图像,并根据摄像头与第二插针工位的水平距离转换获取的针头定位图像的坐标。Preferably, the camera is fixedly disposed between the second pin station and the front surface of the bracket, and is used for shooting from the bottom vertical upward when the liquid injection component drives the needle over the camera and the clamping component is not in the same horizontal position. The needle on the needle mount acquires the needle positioning image and converts the coordinates of the obtained needle positioning image according to the horizontal distance between the camera and the second pin station.
优选地,上述控制模块用于根据针头定位图像中心点的灰度值G0,采用阈值T=G0/K对针头定位图像进行二值化转换,获取二值图像;其中,K为大于1的正整数。Preferably, the control module is configured to perform binary conversion on the needle positioning image according to the gray value G0 of the center point of the needle positioning image, and obtain a binary image by using a threshold T=G0/K; wherein K is greater than 1 Integer.
优选地,上述控制模块用于根据二值图像获取边缘图形,根据边缘图像确定针头的端点的坐标。Preferably, the above control module is configured to acquire an edge pattern according to the binary image, and determine coordinates of the end point of the needle according to the edge image.
优选地,上述控制模块用于通过霍夫变换从二值图像中识别出表示针头的 直线,通过直线的端点确定针头的端点的坐标。Preferably, the above control module is configured to identify the needle representing the needle from the binary image by Hough transform A straight line that determines the coordinates of the endpoint of the needle through the endpoints of the line.
优选地,上述夹持部件用于根据移补偿指令沿着第一方向移动;或者,所述注液部件用于根据移补偿指令沿着与第一方向相反的方向移动。Preferably, the clamping member is configured to move in the first direction according to the shift compensation command; or the liquid injecting member is configured to move in a direction opposite to the first direction according to the shift compensation command.
优选地,上述夹持部件用于通过左夹爪和右夹爪带动药品容器沿着第二方向移动,所述第二方向与第一方向垂直。Preferably, the clamping member is configured to move the medicine container in the second direction by the left and right jaws, the second direction being perpendicular to the first direction.
优选地,上述控制模块用于采用高斯滤波器对二值图像进行平滑处理,采用二阶中心矩算子获取二值化边缘图形;根据预设的灰度值范围从二值化边缘图形确定针头图像区域,根据针头图像区域确定针头的端点的坐标。Preferably, the control module is configured to perform smoothing on the binary image by using a Gaussian filter, obtain a binarized edge pattern by using a second-order central moment operator, and determine a needle from the binarized edge pattern according to a preset gray value range. The image area determines the coordinates of the endpoint of the needle based on the area of the needle image.
一种用于自动配药系统的定位方法,使用上述的定位装置,通过以下步骤实现位移补偿:获取自下垂直向上拍摄的针头定位图像;对针头定位图像进行灰度化处理获取二值图像;根据二值图像获取针头的端点的坐标;根据端点的坐标以及预设的摄像头与针头卡口之间的距离生成位移补偿指令;夹持部件和注液部件根据位移补偿指令进行相对移动以实现位移补偿。A positioning method for an automatic dispensing system, which uses the above-mentioned positioning device to realize displacement compensation by: acquiring a needle positioning image taken from a lower vertical direction; performing grayscale processing on the needle positioning image to obtain a binary image; The binary image acquires the coordinates of the end point of the needle; the displacement compensation command is generated according to the coordinates of the end point and the distance between the preset camera and the needle mount; the clamping component and the liquid injection component are relatively moved according to the displacement compensation command to realize displacement compensation. .
综上所述,由于采用了上述技术方案,本发明至少具有以下有益效果:In summary, due to the adoption of the above technical solutions, the present invention has at least the following beneficial effects:
通过针头定位图像获取针头的端点的坐标,根据针头的端点的坐标进行位移补偿,使针头能够精确地对准药品容器的预设插入位置,进而能够准确、快速地从预设位置插入药品容器,因此提高了配药成功率和配药效率。The coordinates of the end point of the needle are obtained by the needle positioning image, and the displacement compensation is performed according to the coordinates of the end point of the needle, so that the needle can be accurately aligned with the preset insertion position of the medicine container, so that the medicine container can be accurately and quickly inserted from the preset position. Therefore, the success rate of dispensing and the efficiency of dispensing are improved.
附图说明DRAWINGS
图1是本发明一实施例提供的用于自动配药系统的定位装置的结构示意图;1 is a schematic structural view of a positioning device for an automatic dispensing system according to an embodiment of the present invention;
图2是本发明一实施例提供的用于自动配药系统的定位装置中的注液部件的结构示意图;2 is a schematic structural view of a liquid injection component in a positioning device for an automatic dispensing system according to an embodiment of the present invention;
图3是本发明一实施例提供的用于自动配药系统的定位装置中的夹持部件的结构示意图; 3 is a schematic structural view of a clamping member in a positioning device for an automatic dispensing system according to an embodiment of the present invention;
图4A是本发明一实施例提供的用于自动配药系统的定位装置中拍摄针头定位图像的示意图;4A is a schematic diagram of a needle positioning image in a positioning device for an automatic dispensing system according to an embodiment of the present invention;
图4B是本发明一实施例提供的二值化边缘图形的示意图;4B is a schematic diagram of a binarized edge pattern according to an embodiment of the present invention;
图5是本发明一实施例提供的用于自动配药系统的定位方法的流程图。FIG. 5 is a flow chart of a positioning method for an automatic dispensing system according to an embodiment of the present invention.
具体实施方式detailed description
下面结合附图及实施例,对本发明进行进一步详细说明,以使本发明的目的、技术方案及优点更加清楚明白。应当理解,此处所描述的具体实施例仅用以解释本发明,并不用于限定本发明。The present invention will be further described in detail with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
如图1所示,本发明一实施例公开的一种用于自动配药系统的定位装置包括支架1、夹持部件2、注液部件6、摄像头S1以及控制模块C1,其中:As shown in FIG. 1, a positioning device for an automatic dispensing system according to an embodiment of the present invention includes a bracket 1, a clamping member 2, a liquid injection component 6, a camera S1, and a control module C1, wherein:
注液部件6可移动地设置在第一丝杆11上,夹持部件2可移动地设置在第二丝杆12上,第一丝杆11、第二丝杆12平行设置在支架1上。控制模块C1可以如图1所示设置在支架1上,也可以设置在支架1之外的独立支架上。控制模块C1可以包括各种图像或运算处理器并通过沿着支架凹槽设置的线缆与各个电机、摄像头S1等被控器件实现有线连接,也可以通过无线通信接口与各个被控器件实现无线连接。The liquid injection member 6 is movably disposed on the first screw rod 11, and the clamping member 2 is movably disposed on the second screw rod 12. The first screw rod 11 and the second screw rod 12 are disposed in parallel on the bracket 1. The control module C1 may be disposed on the bracket 1 as shown in FIG. 1, or may be disposed on a separate bracket other than the bracket 1. The control module C1 may include various image or arithmetic processors and realize wired connection with controlled devices such as respective motors, cameras S1, etc. through cables disposed along the groove of the bracket, or wirelessly with each controlled device through a wireless communication interface. connection.
如图1~4所示,自动配药系统中,当需要通过固定在注液部件6上的针头62将药品容器101(图中示出的为已经折断瓶头的安瓿瓶)内的药品输入母液中(例如母液容器102)或者将母液容器102内的母液注入药品容器101中时,控制模块C1能够通过控制第一丝杆电机M1驱动注液部件6沿着第一丝杆11从支架1的正面移动至第一插针工位(例如,液部件6位于YZ平面,且针头卡口69的中轴与Z轴重合),通过第二丝杆电机M2驱动夹持部件2带动被夹紧的药品容器101沿着第二丝杆12从支架1的正面移动至第二插针工位(例如, 药品容器101的中轴与Z轴重合),药品容器101的预设插入位置位于针头62正下方。设置在注液部件6上的升降机构68通过针头卡口69带动针头62向下移动并插入药品容器101,以实现药品的注入或抽吸。摄像头S1可以固定在支架1的底部,用于获取自下垂直向上拍摄的针头定位图像,获取的针头定位图像可以通过有线或者无线的方式发生给控制模块C1。As shown in FIGS. 1 to 4, in the automatic dispensing system, when it is necessary to input the medicine in the medicine container 101 (the ampoule which has broken the bottle head shown in the figure) through the needle 62 fixed to the liquid injecting member 6, the mother liquid is input into the mother liquid. When the medium (for example, the mother liquid container 102) or the mother liquid in the mother liquid container 102 is injected into the medicine container 101, the control module C1 can drive the liquid injection unit 6 from the holder 1 along the first screw rod 11 by controlling the first screw motor M1. The front side moves to the first pin station (for example, the liquid member 6 is located in the YZ plane, and the center axis of the needle bayonet 69 coincides with the Z axis), and the clamping member 2 is driven by the second screw motor M2 to drive the clamped portion. The medicine container 101 is moved along the second screw 12 from the front side of the holder 1 to the second pin station (for example, The central axis of the drug container 101 coincides with the Z axis), and the predetermined insertion position of the drug container 101 is located directly below the needle 62. The elevating mechanism 68 provided on the liquid filling member 6 drives the needle 62 to move downward through the needle mount 69 and is inserted into the medicine container 101 to effect injection or suction of the medicine. The camera S1 can be fixed at the bottom of the bracket 1 for acquiring a needle positioning image taken from the lower vertical direction, and the obtained needle positioning image can be generated to the control module C1 by wire or wirelessly.
如图5所示,通过如图1所示的用于自动配药系统的定位装置进行定位的方法包括以下步骤:As shown in FIG. 5, the method of positioning by a positioning device for an automatic dispensing system as shown in FIG. 1 includes the following steps:
步骤501:获取自下垂直向上拍摄的针头定位图像Step 501: Acquire a needle positioning image taken from the bottom vertical direction
具体地,如图4A所示,摄像头S1可以固定设置在第二插针工位的正下方(例如原点O的位置),当注液部件6通过针头卡口69带动针头62到达第一插针工位之后,且夹持部件2未到达第二插针工位之前,自下垂直向上拍摄固定在针头卡口69上的针头62,获取针头定位图像。或者,摄像头S1也可以固定设置在X轴负方向上(例如,第二插针工位与支架1的正面之间),当注液部件6通过针头卡口69带动针头62经过摄像头S1上方,且夹持部件2不在相同水平位置时,自下垂直向上拍摄固定在针头卡口69上的针头62,获取针头定位图像,并根据摄像头S1与第二插针工位(或者原点O)的水平距离,将获取的针头定位图像坐标转换为以原点O为原点的坐标。Specifically, as shown in FIG. 4A, the camera S1 can be fixedly disposed directly below the second pin station (for example, the position of the origin O), and when the liquid injecting member 6 drives the needle 62 to reach the first pin through the needle card slot 69. After the station, and before the gripping member 2 reaches the second pinning station, the needle 62 fixed to the needle mount 69 is photographed from the bottom vertically upward to obtain a needle positioning image. Alternatively, the camera S1 may also be fixedly disposed in the negative direction of the X-axis (for example, between the second pin station and the front surface of the bracket 1). When the liquid-injecting member 6 drives the needle 62 through the needle S through the camera S1, And when the clamping member 2 is not in the same horizontal position, the needle 62 fixed on the needle mount 69 is taken from the bottom vertically upward to obtain the needle positioning image, and according to the level of the camera S1 and the second pin station (or the origin O) The distance is converted into the coordinate of the obtained needle positioning image to the origin with the origin O as the origin.
步骤502:对针头定位图像进行灰度化处理获取二值图像Step 502: Perform grayscale processing on the needle positioning image to obtain a binary image.
具体地,控制模块C1对针头定位图像进行灰度化处理可以包括:根据针头定位图像中心点(例如,固定在针头卡口69的针头62的中心位置)的灰度值G0,采用阈值T=G0/K对针头定位图像进行二值化转换,获取二值图像;其中,K为大于1的正整数。Specifically, the graying process of the needle positioning image by the control module C1 may include: using a threshold value T= according to the gray value G0 of the center point of the image of the needle (for example, the center position of the needle 62 fixed to the needle mount 69). G0/K performs binarization conversion on the needle positioning image to obtain a binary image; wherein K is a positive integer greater than 1.
步骤503:根据二值图像获取针头的端点N的坐标 Step 503: Acquire coordinates of the endpoint N of the needle according to the binary image.
其中,控制模块C1可以根据二值图像获取边缘图形,根据边缘图像确定针头62的端点N在针头定位图像中的坐标(Xn,Yn)。Wherein, the control module C1 can acquire the edge pattern according to the binary image, and determine the coordinates (Xn, Yn) of the end point N of the needle 62 in the needle positioning image according to the edge image.
或者,控制模块C1可以通过霍夫变换(Hough Transform)从二值图像中识别出表示针头62的直线ON,进而通过直线ON的端点确定针头62的端点N的坐标(Xn,Yn)。Alternatively, the control module C1 may recognize the straight line ON indicating the needle 62 from the binary image by Hough Transform, and determine the coordinates (Xn, Yn) of the end point N of the needle 62 by the end point of the straight line ON.
步骤504:根据端点的坐标以及预设的摄像头S1与针头卡口69之间的距离生成位移补偿指令Step 504: Generate a displacement compensation instruction according to the coordinates of the endpoint and the distance between the preset camera S1 and the needle mount 69.
当针头62偏离其中心轴线时(例如针头在安装或者移动过程中因弯曲、偏折等发送变形),即当坐标值Xn和Yn中的任一者不为零时,控制模块C1根据预设的摄像头S1与针头卡口69之间的距离确定坐标的距离单位(例如毫米),并根据端点N的坐标(Xn,Yn)生成位移补偿指令。When the needle 62 is offset from its central axis (for example, the needle is deformed by bending, deflection, etc. during installation or movement), that is, when any of the coordinate values Xn and Yn is not zero, the control module C1 is preset according to the preset. The distance between the camera S1 and the needle mount 69 determines the distance unit (for example, millimeters) of the coordinates, and generates a displacement compensation command based on the coordinates (Xn, Yn) of the end point N.
具体地,当Xn不为零时,控制模块C1生成的位移补偿指令为:第二丝杆电机M2,以转速400rev/min,驱动夹持部件2带动药品容器101沿着第二丝杆远离支架正面的方向(X轴正方向)移动,移动距离为Xn毫米;或者,第一丝杆电机M1,以转速400rev/min,驱动注液部件6带动针头卡口69沿着第一丝杆朝向支架正面的方向(X轴负方向)移动,移动距离为Xn毫米。Specifically, when Xn is not zero, the displacement compensation command generated by the control module C1 is: the second screw motor M2 drives the clamping member 2 to drive the medicine container 101 along the second screw rod away from the bracket at a rotation speed of 400 rev/min. The direction of the front side (the positive direction of the X axis) moves, and the moving distance is Xn mm; or, the first screw motor M1 drives the liquid injection part 6 to drive the needle holder 69 along the first screw rod toward the bracket at a rotation speed of 400 rev/min. The front direction (X-axis negative direction) moves, and the moving distance is Xn mm.
当Yn不为零时,生成的位移补偿指令为:夹持电机M3,以转速400rev/min,驱动夹持部件2中的左夹爪21和右夹爪22带动药品容器101沿着夹持方向(Y轴正或者负方向)移动,移动距离为Yn毫米。When the Yn is not zero, the generated displacement compensation command is: the clamping motor M3 drives the left jaw 21 and the right jaw 22 in the clamping member 2 to drive the medicine container 101 along the clamping direction at a rotation speed of 400 rev/min. (Y-axis positive or negative direction) moves, the moving distance is Yn mm.
步骤505:夹持部件2和注液部件6根据位移补偿指令进行相对移动以实现位移补偿Step 505: The clamping member 2 and the liquid injection member 6 perform relative movement according to the displacement compensation command to realize displacement compensation.
根据位移补偿指令,夹持部件2沿着第二丝杆远离支架正面的方向移动,或者注液部件6沿着第一丝杆朝向支架正面的方向移动;和/或,夹持部件2中 的左夹爪21和右夹爪22带动药品容器101沿着夹持方向移动,最终使针头62精确地对准药品容器101上方预设的插入位置。According to the displacement compensation command, the clamping member 2 moves along the direction in which the second screw rod is away from the front surface of the bracket, or the liquid injection member 6 moves in the direction of the first screw rod toward the front surface of the bracket; and/or, in the clamping member 2 The left jaw 21 and the right jaw 22 move the drug container 101 in the clamping direction, ultimately accurately aligning the needle 62 with the predetermined insertion position above the drug container 101.
在优选的实施例中,与母液容器102或其他种类药品容器(例如,西林瓶)对应的插针被安装在相应的针头卡口后,也可以采用本发明的定位装置和方法进行位移补偿。In a preferred embodiment, the pins corresponding to the mother liquor container 102 or other types of pharmaceutical containers (e.g., vials) are mounted after the corresponding needle mounts, and displacement compensation can also be performed using the positioning apparatus and method of the present invention.
在优选的实施例中,控制模块C1根据边缘图像确定针头的端点N在针头定位图像中的坐标(Xn,Yn)可以包括:采用标准差为2的高斯滤波器对二值图像进行平滑处理,采用二阶中心矩算子获取二值化边缘图形。其中,二阶中心矩算子为二值图像中灰度值的平方均值。In a preferred embodiment, the control module C1 determines that the coordinates (Xn, Yn) of the endpoint N of the needle in the needle positioning image according to the edge image may include: smoothing the binary image with a Gaussian filter having a standard deviation of 2, The second-order central moment operator is used to obtain the binarized edge graph. Wherein, the second-order central moment operator is the square mean of the gray values in the binary image.
图4B示出了本发明一实施例提供的二值化边缘图形,其包括三个区域,与针头卡口对应的卡口图像区域A具有第一灰度值范围(例如200~255),与针头卡端63对应的卡端图像区域B具有第二灰度值范围(例如100~200),与针头62对应的针头图像区域C具有第三灰度值范围(例如0~100)。进一步地,可以根据针头图像区域C中相对于原点O距离最远的点的坐标,可以确定针头的端点N在针头定位图像中的坐标(Xn,Yn)。FIG. 4B illustrates a binarized edge pattern according to an embodiment of the present invention, which includes three regions, and the bayonet image region A corresponding to the needle mount has a first gray value range (for example, 200 to 255), and The card end image area B corresponding to the needle card end 63 has a second gradation value range (for example, 100 to 200), and the needle image area C corresponding to the needle 62 has a third gradation value range (for example, 0 to 100). Further, the coordinates (Xn, Yn) of the end point N of the needle in the needle positioning image can be determined according to the coordinates of the point farthest from the origin O in the needle image region C.
上述实施例中,通过摄像头S1自下垂直向上拍摄的针头定位图像获取表示针头的线段或者图像,进而确定针头的端点的坐标,根据针头的端点的坐标进行对准位置的位移补偿,使得针头精确地对准药品容器的预设位置,针头因此能够准确、快速地从预设位置插入药品容器,提高了配药成功率和配药效率。In the above embodiment, the line segment or image representing the needle is acquired by the camera S1 from the needle positioning image taken from the lower vertical direction, thereby determining the coordinates of the end point of the needle, and the displacement compensation of the alignment position is performed according to the coordinates of the end point of the needle, so that the needle is accurate. Aligning the preset position of the medicine container, the needle can be accurately and quickly inserted into the medicine container from the preset position, thereby improving the medicine success rate and the dispensing efficiency.
以上实施方式仅用于说明本发明的较佳实施例,而非对本发明的限制。相关技术领域的技术人员在不脱离本发明的原则和范围的情况下,做出的各种替换、变型以及改进均应包含在本发明的保护范围之内。 The above embodiments are merely illustrative of preferred embodiments of the invention and are not intended to limit the invention. Various alternatives, modifications, and improvements made by those skilled in the art without departing from the spirit and scope of the invention are intended to be included within the scope of the invention.

Claims (10)

  1. 一种用于自动配药系统的定位装置,其特征在于,所述定位装置包括支架、注液部件、夹持部件、摄像头以及控制模块;其中,所述注液部件可移动地设置在第一丝杆上,夹持部件可移动地设置在第二丝杆上,第一丝杆、第二丝杆平行设置在支架上;A positioning device for an automatic dispensing system, characterized in that the positioning device comprises a bracket, a liquid injection component, a clamping component, a camera and a control module; wherein the liquid injection component is movably disposed on the first wire a clamping member is movably disposed on the second screw rod, and the first screw rod and the second screw rod are disposed in parallel on the bracket;
    所述摄像头,固定设置在支架的底部,用于获取自下垂直向上拍摄的针头定位图像;The camera is fixedly disposed at a bottom of the bracket for acquiring a needle positioning image taken from a lower vertical direction;
    所述控制模块,用于对获取的针头定位图像进行灰度化处理,获取二值图像;根据二值图像获取针头的端点的坐标;根据针头的端点的坐标以及预设的摄像头与针头卡口之间的距离生成位移补偿指令;The control module is configured to perform grayscale processing on the acquired needle positioning image to obtain a binary image; acquire coordinates of the end point of the needle according to the binary image; according to the coordinates of the end point of the needle and the preset camera and the needle mount a distance compensation command is generated between the distances;
    所述夹持部件和注液部件,用于根据位移补偿指令进行相对移动以实现位移补偿。The clamping component and the liquid injection component are configured to perform relative displacement according to the displacement compensation command to implement displacement compensation.
  2. 根据权利要求1所述的定位装置,其特征在于,所述摄像头,固定设置在第二插针工位的正下方,用于当注液部件带动针头到达第一插针工位之后,且夹持部件未到达第二插针工位之前,自下垂直向上拍摄固定在针头卡口上的针头,获取针头定位图像。The positioning device according to claim 1, wherein the camera is fixedly disposed directly below the second pin station for being used after the liquid injecting component drives the needle to reach the first pinning station, and the clip Before the holding component reaches the second pinning station, the needle fixed on the needle holder is photographed from the bottom vertically upward to obtain the needle positioning image.
  3. 根据权利要求1所述的定位装置,其特征在于,所述摄像头,固定设置在第二插针工位与支架的正面之间,用于当注液部件带动针头经过摄像头上方,且夹持部件不在相同水平位置时,自下垂直向上拍摄固定在针头卡口上的针头,获取针头定位图像,并根据摄像头与第二插针工位的水平距离转换获取的针头定位图像的坐标。The positioning device according to claim 1, wherein the camera is fixedly disposed between the second pin station and the front surface of the bracket for driving the needle through the camera and the clamping member When not in the same horizontal position, the needle fixed on the needle holder is photographed from the bottom vertically upward, the needle positioning image is acquired, and the coordinates of the obtained needle positioning image are converted according to the horizontal distance between the camera and the second pin station.
  4. 根据权利要求1所述的定位装置,其特征在于,所述控制模块用于根据针头定位图像中心点的灰度值G0,采用阈值T=G0/K对针头定位图像进行二值化转换,获取二值图像;其中,K为大于1的正整数。 The positioning device according to claim 1, wherein the control module is configured to perform binarization conversion on the needle positioning image by using a threshold value T=G0/K according to the gray value G0 of the center point of the needle positioning image. A binary image; wherein K is a positive integer greater than one.
  5. 根据权利要求4所述的定位装置,其特征在于,所述控制模块用于根据二值图像获取边缘图形,根据边缘图像确定针头的端点的坐标。The positioning device according to claim 4, wherein the control module is configured to acquire an edge pattern according to the binary image, and determine coordinates of an end point of the needle according to the edge image.
  6. 根据权利要求4所述的定位装置,其特征在于,所述控制模块用于通过霍夫变换从二值图像中识别出表示针头的直线,通过直线的端点确定针头的端点的坐标。The positioning device according to claim 4, wherein the control module is configured to recognize a line representing the needle from the binary image by Hough transform, and determine the coordinates of the end point of the needle by the end point of the line.
  7. 根据权利要求1至6中任一项所述的定位装置,其特征在于,所述夹持部件用于根据移补偿指令沿着第一方向移动;或者,所述注液部件用于根据移补偿指令沿着与第一方向相反的方向移动。The positioning device according to any one of claims 1 to 6, wherein the gripping member is configured to move in a first direction according to a shift compensation command; or the liquid injecting member is configured to compensate according to a shift The command moves in a direction opposite to the first direction.
  8. 根据权利要求7所述的定位装置,其特征在于,所述夹持部件用于通过左夹爪和右夹爪带动药品容器沿着第二方向移动,所述第二方向与第一方向垂直。The positioning device according to claim 7, wherein the holding member is configured to move the medicine container in the second direction by the left and right jaws, the second direction being perpendicular to the first direction.
  9. 根据权利要求5所述的定位装置,其特征在于,所述控制模块用于采用高斯滤波器对二值图像进行平滑处理,采用二阶中心矩算子获取二值化边缘图形;根据预设的灰度值范围从二值化边缘图形确定针头图像区域,根据针头图像区域确定针头的端点的坐标。The positioning device according to claim 5, wherein the control module is configured to perform smoothing on the binary image by using a Gaussian filter, and obtain a binarized edge pattern by using a second-order central moment operator; The gray value range determines the needle image area from the binarized edge pattern and determines the coordinates of the end point of the needle based on the needle image area.
  10. 一种用于自动配药系统的定位方法,其特征在于,所述方法使用根据权利要求1至9中任一项所述的定位装置,通过以下步骤实现位移补偿:获取自下垂直向上拍摄的针头定位图像;对针头定位图像进行灰度化处理获取二值图像;根据二值图像获取针头的端点的坐标;根据端点的坐标以及预设的摄像头与针头卡口之间的距离生成位移补偿指令;夹持部件和注液部件根据位移补偿指令进行相对移动以实现位移补偿。 A positioning method for an automatic dispensing system, characterized in that the method uses a positioning device according to any one of claims 1 to 9 to achieve displacement compensation by acquiring a needle shot from the lower vertical direction Positioning the image; performing grayscale processing on the needle positioning image to obtain a binary image; acquiring coordinates of the end point of the needle according to the binary image; generating a displacement compensation instruction according to the coordinates of the endpoint and the distance between the preset camera and the needle mount; The clamping member and the liquid injection member are relatively moved according to the displacement compensation command to achieve displacement compensation.
PCT/CN2017/107125 2016-10-31 2017-10-20 Positioning device and method for automatic medicine dispensing system WO2018077122A1 (en)

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